Kenneth Sherman

Kenneth E. Sherman

Professor of Digestive Diseases

Medical Sciences Building

7161

COM IM Digestive Diseases Division - 0595

Medical Sciences Building, 6th Floor
231 Albert Sabin Way
Cincinnati, Ohio 45267

UC Health Physicians Office - Clifton
222 Piedmont Ave., 4th Floor
Cincinnati, Ohio 45219

UC Health Physicians Office - Montgomery
9275 Montgomery Rd.
Cincinnati, Ohio 45242

Education

Bachelor's Degree, Rutgers University 1976 (Biology)

Doctoral Degree, Rutgers University 1980 (Microbiology)

Medical Degree, George Washington University 1985

Research Fellowship , American Red Cross Blood Research Center 1982 (Transmissible Disease and Immunology Lab )

Research Fellowship , American Red Cross Blood Research Center 1982 (Transmissible Disease and Immunology Lab )

Residency, Tripler Army Medical Center 1988 (Internal Medicine )

Fellowship, Fitzsimons Army Medical Center 1991 (Gastroenterology/Hepatology )

Research Support

Grant: #5 U01 AI052748 Investigators:P Stock, KE Sherman 08-15-2003 -08-31-2011 NIH/NIAID Solid Organ Transplantation in HIV: A Multi Site Study Role:PI $290,272

Grant: #5 U01 AI052748 Investigators:P Stock, KE Sherman 08-15-2003 -08-31-2011 NIH/NIAID Pilot Study - HEV in HIV-Infected Liver Transplant Recipients Role:PI $10,800

Grant: #5 U01 AI69513 Investigators:C Fichtenbaum 12-01-2006 -11-30-2013 NIH/NIAID AIDS Clinical Trials Group (ACTG) Role:Co-I $1,196,010

Grant: #2 K24 DK 070528 Investigators:KE Sherman 03-01-2005 -02-28-2015 NIH/NIDDK Mentorship in Liver Disease $800,000

Grant: #5 R01 AI065256 Investigators:KE Sherman 04-15-2006 -03-31-2012 NIH/NIAID Antiretroviral Therapy and the Hepatitis C Virus $3,347,859

Grant: #5 R13 AI071925 Investigators:KE Sherman 07-01-2006 -05-31-2012 NIH/NIAID, NIDDK, NIDA, NIAAA Liver Disease and HIV Conference $74,800

Grant: #5 R21 AI081564 Investigators:JT Blackard 07-02-2009 -06-30-2012 NIH/NIAID Clinical Relevance of GB Virus C Interactions with HIV and Hepatitis C Virus in High Risk Women Role:Co-I $430,000

Grant: #1 R13 AI071925-01 Investigators:Sherman, Kenneth 07-01-2006 -06-30-2007 National Institute of Allergy and Infectious Diseases Liver Disease and HIV Conference Role:PI $25,000.00 Closed Level:Federal

Grant: #3563sc / U01 AI052748 Investigators:Sherman, Kenneth 08-15-2003 -08-31-2011 National Institute of Allergy and Infectious Diseases Solid Organ Transplantation in HIV: A Multi-Site Study Role:PI $316,611.00 Closed Level:Federal

Investigators:Sherman, Kenneth 01-01-2003 -06-30-2006 National Institute of Allergy and Infectious Diseases Social and Scientific Systems AACTG27.UCINN Role:PI $340,149.02 Closed Level:Federal

Grant: #1-N01-CP-01004-01-A0-S0-E0 Investigators:Sherman, Kenneth 08-15-2003 -10-31-2005 National Cancer Institute Evolution of HIV-1 env in HIV-1-infected Individuals With and Without HCV Coinfection Role:PI $61,400.00 Closed Level:Federal

Grant: #K24 DK070528 Investigators:Sherman, Kenneth 03-01-2005 -03-31-2010 National Inst of Diabetes and Digestive and Kidney Disease Mentorship in Liver Disease Role:PI $583,219.00 Closed Level:Federal

Grant: #R01 AI065256 Investigators:Sherman, Kenneth 04-01-2006 -03-31-2013 National Institute of Allergy and Infectious Diseases Antiretroviral Therapy and the Hepatitis C Virus Role:PI $3,419,727.00 Active Level:Federal

Investigators:Sherman, Kenneth 06-01-2001 -05-31-2006 National Institute of Allergy and Infectious Diseases HCV Genomic Variability in HIV Infected Hemophiliacs Role:PI $2,866,251.04 Closed Level:Federal

Grant: #5-U01-AI-38858-06-A0-S0-E0 Investigators:Sherman, Kenneth 10-01-2000 -12-31-2002 National Institute of Allergy and Infectious Diseases Adult ACTG Central Group Role:PI $301,131.00 Closed Level:Federal

Grant: #2002-UC-14-01-A0-S0-E0 Investigators:Sherman, Kenneth 09-01-2001 -03-31-2003 Social & Scientific Systems, Inc. Social Scientific Systems AACTG.27.NW205.01 Role:PI $66,618.00 Closed Level:Industry

Grant: #5-97-CY-50391-02-A0-S0-E0 Investigators:Sherman, Kenneth 09-27-1997 -05-01-2001 National Cancer Institute HCV Quasispecies Variability in HIV/HCV Co-Infected Role:PI $90,963.00 Closed Level:Federal

Grant: #1-U01-AI-38858-01-A0-S0-E0 Investigators:Sherman, Kenneth 05-01-1999 -09-30-2000 National Institute of Allergy and Infectious Diseases Prevalence of Hepatitis C Virus (HCV) and Distribution of Genotypes in a Representative ACTG Cohort Role:PI $91,379.00 Closed Level:Federal

Grant: #R03HS10366-01-A0-S0-E0 Investigators:Sherman, Kenneth 09-30-1999 -03-31-2001 Agency for Healthcare Research and Quality Health Utilities in Hepatitis C Infected Patients Role:PI $76,072.00 Closed Level:Federal

Grant: #R13 AI071925 Investigators:Russell, Betsy; Sherman, Kenneth 07-01-2006 -03-31-2012 National Institute of Allergy and Infectious Diseases Liver Disease and HIV Role:PI $73,986.00 Closed Level:Federal

Grant: #R21 AI081564 Investigators:Blackard, Jason; Sherman, Kenneth; Welge, Jeffrey 07-02-2009 -06-30-2012 National Institute of Allergy and Infectious Diseases Clinical Relevance of GB Virus C Interactions with HIV and Hepatitis C Virus in High Risk Women Role:Collaborator $429,788.00 Closed Level:Federal

Grant: #3 K24 DK070528-05S1 Investigators:Sherman, Kenneth 01-15-2010 -12-31-2010 National Inst of Diabetes and Digestive and Kidney Disease Mentorship in Liver Disease Role:PI $47,000.00 Closed Level:Federal

Grant: #K24 DK070528 Investigators:Sherman, Kenneth 04-01-2010 -02-28-2015 National Inst of Diabetes and Digestive and Kidney Disease Mentorship in Liver Disease Role:PI $631,260.00 Active Level:Federal

Grant: #Merck 38879 Investigators:Shata, Mohamed Tarek; Sherman, Kenneth 03-30-2011 -03-30-2013 Merck Sharp & Dohme Corp Exploring the Role of Gut-associated Th17 in Microbial Translocation in HIV and HCV/HIV Coinfected Patients Role:Collaborator $160,761.00 Closed Level:Industry

Grant: #SRS 007663 Investigators:Eckman, Mark; Sherman, Kenneth 10-01-2011 -08-13-2013 Merck Sharp & Dohme Corp The Cost Effectiveness of Screening for Chronic Hepatitis C Infection in the United States Role:PI $137,994.00 Active Level:Industry

Grant: #SRS 007747 Investigators:Lin, Ming; Sherman, Kenneth 02-01-2012 -01-31-2013 Bristol-Myers Squibb Co. Development of Novel Methodologies for the Detection of IL28B Single-Nucleotide Polymorphisms in HCV-Infected Patients Role:PI $20,000.00 Active Level:Industry

Grant: #SRS 007837 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Sherman, Kenneth; Ying, Jun 02-15-2012 -02-15-2014 Merck Sharp & Dohme Corp Evaluating the Role of the Immune Responses in the Emergence of HCV NS3 Resistance Mutations During Protease Inhibitor Therapy Role:Collaborator $231,044.00 Active Level:Industry

Grant: #R13AI071925 Investigators:Sherman, Kenneth 04-01-2012 -03-31-2015 National Institute of Allergy and Infectious Diseases Liver Disease and HIV Role:PI $45,900.00 Active Level:Federal

Grant: #BRS-ACURE-S-12-000068-002483 / UM1 AI068636-06 Investigators:Sherman, Kenneth 12-01-2011 -05-31-2012 National Institute of Allergy and Infectious Diseases A Prospective, Phase III, Open-Label Study of Boceprevir, Pegylated-Interferon Alfa 2b and Ribavirin in HCV/HIV Coinfected Subjects Role:PI $10,736.00 Closed Level:Federal

Grant: #BRS-ACURE-S-12-002522 Investigators:Sherman, Kenneth 03-01-2012 -05-31-2014 Merck & Co., Inc. ACTG Protocol A5294 - BIRTH - A Prospective, Phase III, Open-Label Study of Boceprevir, Pegylated-Interferon Alfa 2b and Ribavirin in HCV/HIV Coinfected Subjects Role:PI $39,680.00 Active Level:Industry

Grant: #R34HL109334 Investigators:Sherman, Kenneth 05-25-2012 -04-30-2014 National Heart, Lung and Blood Institute Viral Kinetic Models of HCV Clearance in Hemophiliacs Treated with Telaprevir Role:PI $712,728.00 Active Level:Federal

Grant: #Req No. 2715199 HHSN272201200811P Investigators:Sherman, Kenneth 07-01-2012 -06-30-2014 National Institute of Allergy and Infectious Diseases The Use of Chemokine Receptor 5 (CCR5) Blockade Using a Monoclonal Antibody to Reverse Liver Fibrosis in HIV-infected Subjects Role:PI $50,000.00 Active Level:Federal

Grant: #108400 \ UM1A1068636 Investigators:Blackard, Jason; Sherman, Kenneth 06-01-2012 -12-31-2013 National Institute of Allergy and Infectious Diseases Characterization of HCV Resistance Associated Variants in Liver Tissue Role:PI $187,435.00 Active Level:Federal

Grant: #U01FD004573 Investigators:Alloway, Rita; Kaiser, Tiffany; Sherman, Kenneth; Shields, Adele; Woodle, Ervin Steve 09-15-2012 -09-14-2015 Food and Drug Administration Pharmacokinetic Studies of Tacrolimus in Transplant Patients Role:Collaborator $2,691,189.00 Active Level:Federal

Grant: #108269/AI068636 Investigators:Sherman, Kenneth 06-01-2012 -05-31-2014 National Institute of Allergy and Infectious Diseases Protocol A5294 BIRTH - A Prospective, Phase III, Open-Label Study of Boceprevir, Pegylated-Interferon Alfa 2b And Ribavirin In HCV/HIV Coinfected Subjects Role:PI $31,334.00 Active Level:Federal

Grant: #AI463-980 Investigators:Sherman, Kenneth 08-01-2013 -07-31-2014 Bristol-Myers Squibb Co. Hepatitis C Virus Prevalence: Role of the Emergency Department in Screening Role:PI $20,000.00 Active Level:Industry

Grant: #PRO12060248 (HOTS) Investigators:Sherman, Kenneth 11-01-2013 -12-31-2014 Health Resources and Services Administration Hemophilia Liver Transplant Observational (HOT) Study Role:PI $3,348.00 Awarded Level:Federal

Grant: #110237 / AI068636-08 Investigators:Sherman, Kenneth 01-01-2014 -11-30-2014 National Institute of Allergy and Infectious Diseases AIDS Clinical Trial Group Network - Co-Chair on ACTG Protocol A5294 Role:PI $17,961.00 Active Level:Federal

Grant: #R56 AI065256 Investigators:Sherman, Kenneth 07-01-2014 -06-30-2015 National Institute of Allergy and Infectious Diseases Antiretroviral Therapy and Hepatic Injury Role:PI $524,620.00 Awarded Level:Federal

Grant: #CW432593 Investigators:Sherman, Kenneth 01-01-2015 -12-31-2015 MedImmune Immune Checkpoint Markers in Patients with Chronic Liver Disease Role:PI $151,594.55 Active Level:Industry

Grant: #R01DK108362 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Sherman, Kenneth 09-23-2015 -08-31-2020 National Inst of Diabetes and Digestive and Kidney Disease Hepatitis E in HIV-Infected Patients Role:PI $274,999.00 Awarded Level:Federal

Grant: #R01 AI065256 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Sherman, Kenneth 02-15-2016 -01-31-2020 National Institute of Allergy and Infectious Diseases HIV Antiretroviral Therapy and Hepatic Injury Role:PI $2,124,402.93 Awarded Level:Federal

Grant: #53186 Investigators:Sherman, Kenneth 09-01-2015 -08-31-2016 Merck Sharp & Dohme Corp Ultra-deep Sequencing of NS5A Resistance Variants in HCV/HIV Coinfected Patients Role:PI $78,073.20 Active Level:Industry

Grant: #800005519-01UG/U01DA040381 Investigators:Sherman, Kenneth 09-15-2015 -05-31-2016 National Institute on Drug Abuse Cohort Studies of HIV/AIDS and Substance Abuse in Miami Role:PI $161,007.00 Awarded Level:Federal

Grant: #UFDSP00011086 / PCORI HPC-1503-27891 Investigators:Sherman, Kenneth 03-01-2016 -02-28-2021 Patient-Centered Outcomes Research Institute THE PRIORITIZE STUDY: A Pragmatic, Randomized Study of Oral Regimens for Hepatitis C: Transforming Decision-Making for Patients, Providers, and Stakeholders Role:PI $258,208.50 Awarded Level:Private Non-Profit

Grant: #115113 / UM1 AI068636 Investigators:Sherman, Kenneth 06-01-2016 -11-30-2016 National Institute of Allergy and Infectious Diseases Prevalence and Significance of PNPLA3 Gene Polymorphisms in HCV/HIV Infected Persons Role:PI $70,546.28 Active Level:Federal

Grant: #2016 ACG Investigators:Anwar, Nadeem; Bari, Khurram; Kaiser, Tiffany; Shah, Shimul; Sherman, Kenneth 07-01-2016 -06-30-2017 American College of Gastroenterology A Pilot Study to Evaluate the Safety and Efficacy of Budesonide as an Alternative to Prednisone for Liver Transplant Immune Suppression Role:Collaborator $10,000.00 Active Level:Private Non-Profit

Grant: #R13AI071925 Investigators:Sherman, Kenneth 09-02-2016 -08-31-2017 National Institute of Allergy and Infectious Diseases Liver Disease and HIV Role:PI $40,000.00 Active Level:Federal

Grant: #MISP 55908 Investigators:Eckman, Mark; Paterno, Flavio; Sherman, Kenneth; Thakar, Charuhas; Woodle, Ervin Steve 05-01-2017 -05-01-2019 Merck Sharp & Dohme Corp Timing of Treatment for Chronic Hepatitis C Infection in Patients with End Stage Rengal Disease Awaiting Transplantation Role:PI $96,149.00 Active Level:Industry

Grant: #113237 / A5329 Investigators:Sherman, Kenneth 11-01-2016 -06-29-2018 AbbVie, Inc. Interferon-Free Therapy for Chronic Hepatitis C Virus Genotype 1 Infection in Patients with HIV-1 Coinfection Receiving Concurrent Antiretroviral Therapy Role:PI $9,510.00 Active Level:Industry

Grant: #Independent Contractor Agreement 511 Investigators:Eckman, Mark; Sherman, Kenneth 03-12-2018 -09-30-2018 CDC Foundation The Cost Effectiveness of Screening for Chronic Hepatitis C Infection in the United States: An Update for 2018 Role:PI $30,000.00 Awarded Level:Private Non-Profit

Grant: #1802163 / DA143396 Investigators:Sherman, Kenneth 02-01-2018 -05-31-2022 National Institute on Drug Abuse Immune correlates of long-term success with DAA therapy in HCV/HIV infected people who inject drugs Role:PI $23,412.00 Active Level:Federal

Grant: #R61DA048439 Investigators:Blackard, Jason; Brown, Jennifer; Lyons, Michael; Medvedovic, Mario; Sherman, Kenneth 03-01-2019 -12-31-2021 National Institutes of Health Omics analysis of HIV during synthetic opioid exposure Role:Collaborator $573,135.00 Awarded Level:Federal

Grant: #Clinical Site Agreement Investigators:Sherman, Kenneth 01-01-2018 -12-31-2019 Brigham and Women's Hospital, Inc. A randomized, placebo-controlled pilot study of sulfasalazine for the treatment of Primary Sclerosing Cholangitis (SHIP) Role:PI $10,500.00 Awarded Level:Private Non-Profit

Grant: #1560GWB207 / UM1AI068636 Investigators:Sherman, Kenneth 12-01-2018 -11-30-2019 National Institute of Allergy and Infectious Diseases ACTG Protocol Chair Salary Support - Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG) Role:PI $5,600.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Eckman, Mark H; Kaiser, Tiffany E; Sherman, Kenneth E (2011. )The Cost-effectiveness of Screening for Chronic Hepatitis B Infection in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,52 (11 ),1294-306

Blackard, Jason T; Ma, Gang; Martin, Christina M; Rouster, Susan D; Shata, M Tarek; Sherman, Kenneth E (2011. )HIV Variability in the Liver and Evidence of Possible Compartmentalization.AIDS research and human retroviruses, ,

Taylor, Lynn E; Holubar, Marisa; Wu, Kunling; Bosch, Ronald J; Wyles, David L; Davis, John A; Mayer, Kenneth H; Sherman, Kenneth E; Tashima, Karen T (2011. )Incident hepatitis C virus infection among US HIV-infected men enrolled in clinical trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,52 (6 ),812-8

Blackard, Jason T; Welge, Jeffrey A; Taylor, Lynn E; Mayer, Kenneth H; Klein, Robert S; Celentano, David D; Jamieson, Denise J; Gardner, Lytt; Sherman, Kenneth E (2011. )HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - in women.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,52 (5 ),674-80

Schmeltzer, Paul; Sherman, Kenneth E (2010. )Occult hepatitis B: clinical implications and treatment decisions.Digestive diseases and sciences, ,55 (12 ),3328-35

Sulkowski, Mark S; Shiffman, Mitchell L; Afdhal, Nezam H; Reddy, K Rajender; McCone, Jonathan; Lee, William M; Herrine, Steven K; Harrison, Stephen A; Poordad, F Fred; Koury, Kenneth; Deng, Weiping; Noviello, Stephanie; Pedicone, Lisa D; Brass, Clifford A; Albrecht, Janice K; McHutchison, John G (2010. )Hepatitis C virus treatment-related anemia is associated with higher sustained virologic response rate.Gastroenterology, ,139 (5 ),1602-11, 1611.e1

Blackard, Jason T; Ma, Gang; Limketkai, Berkeley N; Welge, Jeffrey A; Dryer, Peter D; Martin, Christina M; Hiasa, Yoichi; Taylor, Lynn E; Mayer, Kenneth H; Jamieson, Denise J; Sherman, Kenneth E (2010. )Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women.Journal of clinical microbiology, ,48 (11 ),4256-9

Sherman, Kenneth E; Andersen, Janet W; Butt, Adeel A; Umbleja, Triin; Alston, Beverly; Koziel, Margaret J; Peters, Marion G; Sulkowski, Mark; Goodman, Zachary D; Chung, Raymond T (2010. )Sustained Long-Term Antiviral Maintenance Therapy in HCV/HIV-Coinfected Patients (SLAM-C).Journal of acquired immune deficiency syndromes (1999), ,

Kemmer, Nyingi M; Sherman, Kenneth E (2010. )Hepatitis C-related arthropathy: Diagnostic and treatment considerations. The Journal of musculoskeletal medicine, ,27 (9 ),351-354

Sherman, Kenneth E (2010. )Thymosin alpha 1 for treatment of hepatitis C virus: promise and proof.Annals of the New York Academy of Sciences, ,1194 ,136-40

McHutchison, John; Goodman, Zachary; Patel, Keyur; Makhlouf, Hala; Rodriguez-Torres, Maribel; Shiffman, Mitchell; Rockey, Don; Husa, Petr; Chuang, Wan-Long; Levine, Robert; Jonas, Mark; Theodore, Dickens; Brigandi, Richard; Webster, Alison; Schultz, Margaret; Watson, Helen; Stancil, Britt; Gardner, Stephen (2010. )Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection.Gastroenterology, ,138 (4 ),1365-73, 1373.e1-2

Sherman, Kenneth E; Soriano, Vincent; Chung, Raymond T (2010. )Human immunodeficiency virus and liver disease: conference proceedings.Hepatology (Baltimore, Md.), ,51 (3 ),1046-54

Sherman, Kenneth E; Rouster, Susan D; Stanford, Sandra; Blackard, Jason T; Shire, Norah; Koziel, Margaret; Peters, Marion; Chung, Raymond T (2010. )Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens.The Journal of infectious diseases, ,201 (5 ),712-9

Dryer, Peter D; Limketkai, Berkeley N; Martin, Christina M; Ma, Gang; Sherman, Kenneth E; Taylor, Lynn E; Mayer, Kenneth H; Jamieson, Denise J; Blackard, Jason T (2009. )Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women.The Journal of antimicrobial chemotherapy, ,64 (5 ),945-8

Blackard, Jason T; Rouster, Susan D; Nady, Soad; Galal, Gehan; Marzuuk, Naglaa; Rafaat, Marwaa M; Daef, Enas; El Din, Salwa Seif; Purcell, Robert H; Emerson, Suzanne U; Sherman, Kenneth E; Shata, M Tarek (2009. )Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, ,46 (2 ),140-4

Martin, Christina M; Welge, Jeffrey A; Shire, Norah J; Shata, Mohamed T; Sherman, Kenneth E; Blackard, Jason T (2009. )Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals.Cytokine, ,47 (3 ),194-8

Sherman, Kenneth; Belkin, Igor M; Friedland, Kevin D; O'Reilly, John; Hyde, Kimberly (2009. )Accelerated warming and emergent trends in fisheries biomass yields of the world's large marine ecosystems. Ambio, ,38 (4 ),215-24

Poynard, Thierry; Colombo, Massimo; Bruix, Jordi; Schiff, Eugene; Terg, Ruben; Flamm, Steven; Moreno-Otero, Ricardo; Carrilho, Flair; Schmidt, Warren; Berg, Thomas; McGarrity, Thomas; Heathcote, E Jenny; Gon├žales, Fernando; Diago, Moises; Craxi, Antonio; Silva, Marcelo; Bedossa, Pierre; Mukhopadhyay, Pabak; Griffel, Louis; Burroughs, Margaret; Brass, Clifford; Albrecht, Janice (2009. )Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy.Gastroenterology, ,136 (5 ),1618-28.e2

Shire, Norah J; Rao, Marepalli B; Succop, Paul; Buncher, C Ralph; Andersen, Janet A; Butt, Adeel A; Chung, Raymond T; Sherman, Kenneth E (2009. )Improving noninvasive methods of assessing liver fibrosis in patients with hepatitis C virus/human immunodeficiency virus co-infection.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, ,7 (4 ),471-80, 480.e1-2

Atiq, Muslim; Shire, Norah J; Barrett, Anna; Rouster, Susan D; Sherman, Kenneth E; Shata, Mohamed T (2009. )Hepatitis E virus antibodies in patients with chronic liver disease. Emerging infectious diseases, ,15 (3 ),479-81

Gordon, Stuart C; Sherman, Kenneth E (2009. )Treatment of HBV/HCV coinfection: releasing the enemy within.Gastroenterology, ,136 (2 ),393-6

Kemmer, Nyingi; Sherman, Kenneth E (2008. )What is the impact of HIV infection on survival after liver transplantation?.Nature clinical practice. Gastroenterology & hepatology, ,5 (8 ),426-7

Blackard, Jason T; Shata, M Tarek; Shire, Norah J; Sherman, Kenneth E (2008. )Acute hepatitis C virus infection: a chronic problem.Hepatology (Baltimore, Md.), ,47 (1 ),321-31

Sherman, Kenneth E; Fleischer, Russell; Laessig, Katherine; Murray, Jeffrey; Tauber, William; Birnkrant, Debra (2007. )Development of novel agents for the treatment of chronic hepatitis C infection: Summary of the FDA Antiviral Products Advisory Committee recommendations.Hepatology (Baltimore, Md.), ,46 (6 ),2014-20

Sherman, Kenneth E; Peters, Marion; Koziel, Margaret James (2007. )HIV and liver disease forum: conference proceedings.Hepatology (Baltimore, Md.), ,45 (6 ),1566-77

Alatrakchi, Nadia; Graham, Camilla S; van der Vliet, Hans J J; Sherman, Kenneth E; Exley, Mark A; Koziel, Margaret James (2007. )Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses.Journal of virology, ,81 (11 ),5882-92

Sherman, Kenneth E; Goodman, Zachary D; Sullivan, Sara T; Faris-Young, Sima (2007. )Liver biopsy in cirrhotic patients.The American journal of gastroenterology, ,102 (4 ),789-93

Blackard, Jason T; Kang, Minhee; St Clair, J Benjamin; Lin, Wenyu; Kamegaya, Yoshitaka; Sherman, Kenneth E; Koziel, Margaret James; Peters, Marion G; Andersen, Janet; Chung, Raymond T (2007. )Viral factors associated with cytokine expression during HCV/HIV co-infection.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, ,27 (4 ),263-9

Shire, Norah J; Rouster, Susan D; Stanford, Sandra D; Blackard, Jason T; Martin, Christina M; Fichtenbaum, Carl J; Sherman, Kenneth E (2007. )The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients.Journal of acquired immune deficiency syndromes (1999), ,44 (3 ),309-14

Blackard, Jason T; Sherman, Kenneth E (2007. )Hepatitis C virus coinfection and superinfection.The Journal of infectious diseases, ,195 (4 ),519-24

Sherman, Kenneth E (2007. )New paradigms in the management of hepatitis C virus co-infections.Nature clinical practice. Gastroenterology & hepatology, ,4 Suppl 1 ,S10-6

Shire, Norah J; Horn, Paul S; Rouster, Susan D; Stanford, Sandra; Eyster, M Elaine; Sherman, Kenneth E (2006. )HCV kinetics, quasispecies, and clearance in treated HCV-infected and HCV/HIV-1-coinfected patients with hemophilia.Hepatology (Baltimore, Md.), ,44 (5 ),1146-57

Peters, Marion G; Andersen, Janet; Lynch, Patrick; Liu, Tun; Alston-Smith, Beverly; Brosgart, Carol L; Jacobson, Jeffrey M; Johnson, Victoria A; Pollard, Richard B; Rooney, James F; Sherman, Kenneth E; Swindells, Susan; Polsky, Bruce (2006. )Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127.Hepatology (Baltimore, Md.), ,44 (5 ),1110-6

Blackard, Jason T; Kang, Minhee; Sherman, Kenneth E; Koziel, Margaret James; Peters, Marion G; Chung, Raymond T (2006. )Effects of HCV treatment on cytokine expression during HCV/HIV coinfection.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, ,26 (11 ),834-8

Mann, Elizabeth A; Stanford, Sandra; Sherman, Kenneth E (2006. )Prevalence of mutations in hepatitis C virus core protein associated with alteration of NF-kappaB activation.Virus research, ,121 (1 ),51-7

Schwarze-Zander, Carolynne; Blackard, Jason T; Zheng, Hui; Addo, Marylyn M; Lin, Wenyu; Robbins, Gregory K; Sherman, Kenneth E; Zdunek, Dietmar; Hess, Georg; Chung, Raymond T (2006. )GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype.The Journal of infectious diseases, ,194 (4 ),410-9

Blackard, Jason T; Kemmer, Nyingi; Sherman, Kenneth E (2006. )Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences.Hepatology (Baltimore, Md.), ,44 (1 ),15-22

Atiq, Muslim; Neff, Guy W; Buell, Joseph; Kemmer, Nyingi; Rudich, Steven; Weber, Fred; Sherman, Kenneth (2006. )Rhabdomylysis transference during liver transplantation.Transplantation, ,81 (9 ),1359-60

Mandac, Jamie C; Chaudhry, Sonal; Sherman, Kenneth E; Tomer, Yaron (2006. )The clinical and physiological spectrum of interferon-alpha induced thyroiditis: toward a new classification.Hepatology (Baltimore, Md.), ,43 (4 ),661-72

Graham, Camilla S; Wells, Annalee; Liu, Tun; Sherman, Kenneth E; Peters, Marion; Chung, Raymond T; Bhan, Atul K; Andersen, Janet; Koziel, Margaret James (2006. )Relationships between cellular immune responses and treatment outcomes with interferon and ribavirin in HIV/hepatitis C virus co-infection.AIDS (London, England), ,20 (3 ),345-51

Mrus, Joseph M; Sherman, Kenneth E; Leonard, Anthony C; Sherman, Susan N; Mandell, Karen L; Tsevat, Joel (2006. )Health values of patients coinfected with HIV/hepatitis C: are two viruses worse than one? .Medical care, ,44 (2 ),158-66

Shire, Norah J; Welge, Jeffrey A; Sherman, Kenneth E (2006. )Efficacy of inactivated hepatitis A vaccine in HIV-infected patients: a hierarchical bayesian meta-analysis.Vaccine, ,24 (3 ),272-9

Sherman, Kenneth E; Shire, Norah J; Cernohous, Paul; Rouster, Susan D; Omachi, Janice H; Brun, Scott; Da Silva, Barbara (2005. )Liver injury and changes in hepatitis C Virus (HCV) RNA load associated with protease inhibitor-based antiretroviral therapy for treatment-naive HCV-HIV-coinfected patients: lopinavir-ritonavir versus nelfinavir.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,41 (8 ),1186-95

Sherman, Kenneth E (2005. )Treatment of hepatitis C virus and human immunodeficiency virus co-infection. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, ,3 (10 Suppl 2 ),S118-21

Chun, Sooyun; Sherman, Kenneth E (2005. )Treatment of hepatitis C virus/HIV coinfection.Clinics in liver disease, ,9 (3 ),525-33, ix

Shire, Norah J; Sherman, Kenneth E (2005. )Clinical trials of treatment for hepatitis C virus infection in HIV-infected patients: past, present, and future.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,41 Suppl 1 ,S63-8

Graham, Camilla S; Wells, Annalee; Liu, Tun; Sherman, Kenneth E; Peters, Marion; Chung, Raymond T; Bhan, Atul K; Andersen, Janet; Koziel, Margaret James (2005. )Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection. AIDS (London, England), ,19 (8 ),767-73

Alatrakchi, Nadia; Graham, Camilla S; He, Qi; Sherman, Kenneth E; Koziel, Margaret James (2005. )CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection.The Journal of infectious diseases, ,191 (5 ),702-9

Glesby, Marshall J; Bassett, Roland; Alston-Smith, Beverly; Fichtenbaum, Carl; Jacobson, Elizabeth L; Brass, Clifford; Owens, Susan; Sulkowski, Mark; Race, Elizabeth M; Sherman, Kenneth E (2005. )Pilot study of low-dose interleukin-2, pegylated interferon-alpha 2b, and ribavirin for the treatment of hepatitis C virus infection in patients with HIV infection.The Journal of infectious diseases, ,191 (5 ),686-93

Lienesch, Douglas; Morris, Robert; Metzger, Allan; Debuys, Paige; Sherman, Kenneth (2005. )Absence of cyclic citrullinated peptide antibody in nonarthritic patients with chronic hepatitis C infection. The Journal of rheumatology, ,32 (3 ),489-93

Sherman, Kenneth E; Shire, Norah J; Rouster, Susan D; Peters, Marion G; James Koziel, Margaret; Chung, Raymond T; Horn, Paul S (2005. )Viral kinetics in hepatitis C or hepatitis C/human immunodeficiency virus-infected patients. Gastroenterology, ,128 (2 ),313-27

Qin, Hongxing; Shire, Norah J; Keenan, Erica D; Rouster, Susan D; Eyster, M Elaine; Goedert, James J; Koziel, Margaret James; Sherman, Kenneth E (2005. )HCV quasispecies evolution: association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV.Blood, ,105 (2 ),533-41

Shire, Norah J; Sherman, Kenneth E (2005. )Management of HBV/HIV-coinfected Patients.Seminars in liver disease, ,25 Suppl 1 ,48-57

Sherman, Kenneth E; Sherman, Susan N; Chenier, Thomas; Tsevat, Joel (2004. )Health values of patients with chronic hepatitis C infection.Archives of internal medicine, ,164 (21 ),2377-82

Zucker, Stephen D; Horn, Paul S; Sherman, Kenneth E (2004. )Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer.Hepatology (Baltimore, Md.), ,40 (4 ),827-35

Morelli, Michael S; Rouster, Susan D; Giannella, Ralph A; Sherman, Kenneth E (2004. )Clinical application of polymerase chain reaction to diagnose Clostridium difficile in hospitalized patients with diarrhea. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, ,2 (8 ),669-74

Keenan, Erica D; Rouster, Susan D; Shire, Norah J; Horn, Paul S; Sherman, Kenneth E (2004. )Complexity and diversity of hepatitis C virus RNA in african americans and whites: analysis of the envelope-coding domain.The Journal of infectious diseases, ,190 (3 ),511-4

Chung, Raymond T; Andersen, Janet; Volberding, Paul; Robbins, Gregory K; Liu, Tun; Sherman, Kenneth E; Peters, Marion G; Koziel, Margaret J; Bhan, Atul K; Alston, Beverly; Colquhoun, Dodi; Nevin, Tom; Harb, George; van der Horst, Charles (2004. )Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons.The New England journal of medicine, ,351 (5 ),451-9

Graham, Camilla S; Curry, Michael; He, Qi; Afdhal, Nezam; Nunes, David; Fleming, Catherine; Horsburgh, Robert; Craven, Donald; Sherman, Kenneth E; Koziel, Margaret James (2004. )Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV.Hepatology (Baltimore, Md.), ,40 (1 ),125-32

Shire, Norah J; Rouster, Susan D; Rajicic, Natasa; Sherman, Kenneth E (2004. )Occult hepatitis B in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999), ,36 (3 ),869-75

Zucker, Stephen D; Sherman, Kenneth E (2004. )Beyond interferon for hepatitis C: living in the present while hoping for the future. Gastroenterology, ,126 (5 ),1487-8

Fleischer, Russell; Boxwell, Debra; Sherman, Kenneth E (2004. )Nucleoside analogues and mitochondrial toxicity.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,38 (8 ),e79-80

Blackard, Jason T; Yang, Yijun; Bordoni, Paola; Sherman, Kenneth E; Chung, Raymond T (2004. )Hepatitis C virus (HCV) diversity in HIV-HCV-coinfected subjects initiating highly active antiretroviral therapy.The Journal of infectious diseases, ,189 (8 ),1472-81

Sherman, Kenneth E (2004. )HCV and HIV: a tale of two viruses. Reviews in gastroenterological disorders, ,4 Suppl 1 ,S48-54

Shiramizu, Bruce; Theodore, Dickens; Bassett, Roland; Coel, Marc; Sherman, Kenneth E; Glesby, Marshall J; Chow, Dominic; Alston, Beverly; Colquhoun, Dodi; Merigan, Thomas C; Reichman, Richard C; Berggren, Ruth; Burning, Wendy Jo; Brobst, Susan (2003. )Correlation of single photon emission computed tomography parameters as a noninvasive alternative to liver biopsies in assessing liver involvement in the setting of HIV and hepatitis C virus coinfection: a multicenter trial of the Adult AIDS Clinical Trials Group. Journal of acquired immune deficiency syndromes (1999), ,33 (3 ),329-35

Keiserman, Daniela R; Both, Cristiane T; Mattos, Angelo A; Remiao, Jose; Alexandre, Claudio O P; Sherman, Kenneth E (2003. )Intrafamilial transmission of hepatitis C virus in patients with hepatitis C and human immunodeficiency virus coinfection.The American journal of gastroenterology, ,98 (4 ),878-83

Sherman, Kenneth E (2003. )Implications of peginterferon use in special populations infected with HCV.Seminars in liver disease, ,23 Suppl 1 ,47-52

Chung, Raymond T; Evans, Scott R; Yang, Yijun; Theodore, Dickens; Valdez, Hernan; Clark, Rebecca; Shikuma, Cecilia; Nevin, Thomas; Sherman, Kenneth E (2002. )Immune recovery is associated with persistent rise in hepatitis C virus RNA, infrequent liver test flares, and is not impaired by hepatitis C virus in co-infected subjects. AIDS (London, England), ,16 (14 ),1915-23

Goedert, James J; Eyster, M Elaine; Lederman, Michael M; Mandalaki, Titica; De Moerloose, Philippe; White, Gilbert C; Angiolillo, Anne L; Luban, Naomi L C; Sherman, Kenneth E; Manco-Johnson, Marilyn; Preiss, Liliana; Leissinger, Cindy; Kessler, Craig M; Cohen, Alan R; DiMichele, Donna; Hilgartner, Margaret W; Aledort, Louis M; Kroner, Barbara L; Rosenberg, Philip S; Hatzakis, Angelos (2002. )End-stage liver disease in persons with hemophilia and transfusion-associated infections. Blood, ,100 (5 ),1584-9

Sherman, Kenneth E; Rouster, Susan D; Horn, Paul S (2002. )Comparison of methodologies for quantification of hepatitis C virus (HCV) RNA in patients coinfected with HCV and human immunodeficiency virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,35 (4 ),482-7

Ajayi, Thomas; Sherman, Kenneth; Tang, Qisheng (2002. )Support of marine sustainability science. Science (New York, N.Y.), ,297 (5582 ),772

Bleau, Brian L; Gostout, Christopher J; Sherman, Kenneth E; Shaw, Michael J; Harford, William V; Keate, Ray F; Bracy, Waldo P; Fleischer, David E (2002. )Recurrent bleeding from peptic ulcer associated with adherent clot: a randomized study comparing endoscopic treatment with medical therapy. Gastrointestinal endoscopy, ,56 (1 ),1-6

Sherman, Kenneth E (2002. )Diagnosis and management of the HCV/HIV-coinfected patient. AIDS clinical care, ,14 (5 ),39-43, 48

Sherman, Kenneth E; Rouster, Susan D; Chung, Raymond T; Rajicic, Natasa (2002. )Hepatitis C Virus prevalence among patients infected with Human Immunodeficiency Virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,34 (6 ),831-7

Honors and Awards

1979 Sigma Xi (National Research Honor Society)

1976 Alpha Zeta (National Agricultural Honor Society)

1976 -1980 Busch Pre-doctoral Fellow at the Waksman Institute for Microbiology

1976 B.S. with High Honors (Magna Cum)

1985 George Washington University Donald Glew Medical Student Research Award

1989 Army Achievement Medal (Research Activities)

1989 William Beaumont Award for Clinical Research in Gastroenterology

1994 Army Meritorious Service Medal

2005 Who's Who in America 59th Edition

2005 -2010 Best Doctors in America

Alpha Omega Alpha (AOA)

Positions and Work Experience

1999 -2003 Director, Clinical Trials Research Office - Department of Medicine, University of Cincinnati, Cincinnati, OH

1998 -2004 Director, Hepatology & Liver Transplant Medicine Section, University of Cincinnati, Cincinnati, OH

1994 -2003 Program Director, GI Fellowship, University of Cincinnati, Cincinnati, OH

1994 -2001 Associate Professor of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1992 -1994 Chief, Department of Clinical Investigation, Fitzsimons Army Medical Center,

1991 -1994 Staff Hepatologist/Gastroenterologist, Fitzsimons Army Medical Center,

1991 -1994 Assistant Clinical Professor of Medicine, University of Colorado School of Medicine,

1989 -1991 Assistant Clinical Professor of Medicine, University of Hawaii School of Medicine,

1988 -1989 Staff, Internal Medicine Service,

1981 -1982 Instructor , Microbiology, George Washington Unviersity School of Medicine,

1978 -1980 Adjunct Faculty in Biology, Middlesex College, Edison, NJ

Keywords

Pharmacoepidemiology(MeSH PhrmEpi),Digestive System(MeSH A03),Viruses(MeSH B04),Virus Diseases(MeSH C02),Digestive System Diseases(MeSH C06),Nucleic Acids, Nucleotides, and Nucleosides(MeSH D13),Diagnosis(MeSH E01),Therapeutics(MeSH E02),Investigative Techniques(MeSH E05),Digestive, Oral, and Skin Physiology(MeSH G10)

Research and Practice Interests

Viral Hepatitis - Molecular Heterogeneity, Diagnosis and Treatment, Liver Disease in HIV Infected Patients, Drug Hepatotoxicity.

Preferred Information

Professor of Digestive Diseases, Sherman, Kenneth MD, PhD

Contact Information

Academic - Medical Sciences Building, 6th Floor
231 Albert Sabin Way
Ohio, 45267
Phone: 513-558-7200
Fax: 513-558-1744
shermake@ucmail.uc.edu

Clinical - UC Health Physicians Office - Clifton
222 Piedmont Ave., 4th Floor
Ohio, 45219
Phone: 513-475-8000
Fax: 513-475-9355
shermake@ucmail.uc.edu

Clinical - UC Health Physicians Office - Montgomery
9275 Montgomery Rd.
Ohio, 45242
Phone: 513-475-8000
Fax: 513-475-7723
shermake@ucmail.uc.edu