Soona Shin

Soona Shin , PhD

Assistant Professor-Affiliate

Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229
Phone 513-803-8970


Master's Degree: Seoul National University 2004 (Pharmacy)

Doctoral Degree: Johns Hopkins University 2009 (Pharmacology and Molecular Sciences)

Postdoctoral Study: University of Pennsylvania 2012 (Genetics)


Peer Reviewed Publications

Shin, Soona; Wangensteen, Kirk J; Teta-Bissett, Monica; Wang, Yue J; Mosleh-Shirazi, Elham; Buza, Elizabeth L; Greenbaum, Linda E; Kaestner, Klaus H (2016. ) Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice.Hepatology (Baltimore, Md.), , 64 (4 ) ,1163-1177 More Information

Aoki, Reina; Shoshkes-Carmel, Michal; Gao, Nan; Shin, Soona; May, Catherine L; Golson, Maria L; Zahm, Adam M; Ray, Michael; Wiser, Caroline L; Wright, Christopher V E; Kaestner, Klaus H (2016. ) Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche.Cellular and molecular gastroenterology and hepatology, , 2 (2 ) ,175-188 More Information

Shin, Soona; Upadhyay, Naman; Greenbaum, Linda E; Kaestner, Klaus H (2015. ) Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury.Gastroenterology, , 148 (1 ) ,192-202.e3 More Information

Shin, Soona; Le Lay, John; Everett, Logan J; Gupta, Rana; Rafiq, Kiran; Kaestner, Klaus H (2014. ) CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse ?-cells.Molecular metabolism, , 3 (8 ) ,803-12 More Information

Shin, Soona; Kaestner, Klaus H (2014. ) The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells.Current topics in developmental biology, , 107 ,269-92 More Information

Bochkis, Irina Mikhailovna; Shin, Soona; Kaestner, Klaus Hermann (2013. ) Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity.Molecular metabolism, , 2 (4 ) ,447-56 More Information

Shin, Soona; Walton, Gabriel; Aoki, Reina; Brondell, Karrie; Schug, Jonathan; Fox, Alan; Smirnova, Olga; Dorrell, Craig; Erker, Laura; Chu, Andrew S; Wells, Rebecca G; Grompe, Markus; Greenbaum, Linda E; Kaestner, Klaus H (2011. ) Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential.Genes & development, , 25 (11 ) ,1185-92 More Information

Lee, Won-Hee; Choi, Joon-Seok; Byun, Mi-Ran; Koo, Kyo-Tan; Shin, Soona; Lee, Seung-Ki; Surh, Young-Joon (2010. ) Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2.Toxicology, , 278 (2 ) ,224-8 More Information

Wakabayashi, Nobunao; Slocum, Stephen L; Skoko, John J; Shin, Soona; Kensler, Thomas W (2010. ) When NRF2 talks, who's listening?.Antioxidants & redox signaling, , 13 (11 ) ,1649-63 More Information

Wakabayashi, Nobunao; Shin, Soona; Slocum, Stephen L; Agoston, Elin S; Wakabayashi, Junko; Kwak, Mi-Kyoung; Misra, Vikas; Biswal, Shyam; Yamamoto, Masayuki; Kensler, Thomas W (2010. ) Regulation of notch1 signaling by nrf2: implications for tissue regeneration.Science signaling, , 3 (130 ) ,ra52 More Information

Sackett, Sara D; Gao, Yan; Shin, Soona; Esterson, Yonah B; Tsingalia, Akivaga; Hurtt, Reginald S; Brondell, Karrie; Kaestner, Klaus H; Greenbaum, Linda E (2009. ) Foxl1 promotes liver repair following cholestatic injury in mice.Laboratory investigation; a journal of technical methods and pathology, , 89 (12 ) ,1387-96 More Information

Shin, Soona; Wakabayashi, Junko; Yates, Melinda S; Wakabayashi, Nobunao; Dolan, Patrick M; Aja, Susan; Liby, Karen T; Sporn, Michael B; Yamamoto, Masayuki; Kensler, Thomas W (2009. ) Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.European journal of pharmacology, , 620 (1-3 ) ,138-44 More Information

Shin, Soona; Wakabayashi, Nobunao; Misra, Vikas; Biswal, Shyam; Lee, Gum Hwa; Agoston, Elin S; Yamamoto, Masayuki; Kensler, Thomas W (2007. ) NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis.Molecular and cellular biology, , 27 (20 ) ,7188-97 More Information

Kwak, Mi-Kyoung; Cho, Jeong-Min; Huang, Bo; Shin, Soona; Kensler, Thomas W (2007. ) Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells.Free radical biology & medicine, , 43 (5 ) ,809-17 More Information

Choi, Joon-Seok; Shin, Soona; Jin, Ying Hua; Yim, Hyungshin; Koo, Kyo-Tan; Chun, Kwang-Hoon; Oh, You-Take; Lee, Won Hee; Lee, Seung-Ki (2007. ) Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis.Apoptosis : an international journal on programmed cell death, , 12 (7 ) ,1229-41 More Information

Jin, Ying Hua; Choi, JoonSeok; Shin, Soona; Lee, Kwang Youl; Park, Jeong Hill; Lee, Seung Ki (2003. ) Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells.Carcinogenesis, , 24 (11 ) ,1767-72 More Information

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
CincinnatiĀ  Ohio, 45229
Phone: 513-803-8970