Soona Shin

Soona Shin

Assistant Professor of Surgery

Childrens Hospital Bldg R

COM Surgery Pediatric - 2023

Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229


Master's Degree, Seoul National University 2004 (Pharmacy)

Doctoral Degree, Johns Hopkins University 2009 (Pharmacology and Molecular Sciences)

Postdoctoral Study, University of Pennsylvania 2012 (Genetics)


Peer Reviewed Publications

Shin, Soona; Wangensteen, Kirk J; Teta-Bissett, Monica; Wang, Yue J; Mosleh-Shirazi, Elham; Buza, Elizabeth L; Greenbaum, Linda E; Kaestner, Klaus H (2016. )Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice.Hepatology (Baltimore, Md.), ,64 (4 ),1163-1177

Aoki, Reina; Shoshkes-Carmel, Michal; Gao, Nan; Shin, Soona; May, Catherine L; Golson, Maria L; Zahm, Adam M; Ray, Michael; Wiser, Caroline L; Wright, Christopher V E; Kaestner, Klaus H (2016. )Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche.Cellular and molecular gastroenterology and hepatology, ,2 (2 ),175-188

Shin, Soona; Upadhyay, Naman; Greenbaum, Linda E; Kaestner, Klaus H (2015. )Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury.Gastroenterology, ,148 (1 ),192-202.e3

Shin, Soona; Le Lay, John; Everett, Logan J; Gupta, Rana; Rafiq, Kiran; Kaestner, Klaus H (2014. )CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse ?-cells.Molecular metabolism, ,3 (8 ),803-12

Shin, Soona; Kaestner, Klaus H (2014. )The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells.Current topics in developmental biology, ,107 ,269-92

Bochkis, Irina Mikhailovna; Shin, Soona; Kaestner, Klaus Hermann (2013. )Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity.Molecular metabolism, ,2 (4 ),447-56

Shin, Soona; Walton, Gabriel; Aoki, Reina; Brondell, Karrie; Schug, Jonathan; Fox, Alan; Smirnova, Olga; Dorrell, Craig; Erker, Laura; Chu, Andrew S; Wells, Rebecca G; Grompe, Markus; Greenbaum, Linda E; Kaestner, Klaus H (2011. )Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential.Genes & development, ,25 (11 ),1185-92

Lee, Won-Hee; Choi, Joon-Seok; Byun, Mi-Ran; Koo, Kyo-Tan; Shin, Soona; Lee, Seung-Ki; Surh, Young-Joon (2010. )Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2.Toxicology, ,278 (2 ),224-8

Wakabayashi, Nobunao; Slocum, Stephen L; Skoko, John J; Shin, Soona; Kensler, Thomas W (2010. )When NRF2 talks, who's listening?.Antioxidants & redox signaling, ,13 (11 ),1649-63

Wakabayashi, Nobunao; Shin, Soona; Slocum, Stephen L; Agoston, Elin S; Wakabayashi, Junko; Kwak, Mi-Kyoung; Misra, Vikas; Biswal, Shyam; Yamamoto, Masayuki; Kensler, Thomas W (2010. )Regulation of notch1 signaling by nrf2: implications for tissue regeneration.Science signaling, ,3 (130 ),ra52

Sackett, Sara D; Gao, Yan; Shin, Soona; Esterson, Yonah B; Tsingalia, Akivaga; Hurtt, Reginald S; Brondell, Karrie; Kaestner, Klaus H; Greenbaum, Linda E (2009. )Foxl1 promotes liver repair following cholestatic injury in mice.Laboratory investigation; a journal of technical methods and pathology, ,89 (12 ),1387-96

Shin, Soona; Wakabayashi, Junko; Yates, Melinda S; Wakabayashi, Nobunao; Dolan, Patrick M; Aja, Susan; Liby, Karen T; Sporn, Michael B; Yamamoto, Masayuki; Kensler, Thomas W (2009. )Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.European journal of pharmacology, ,620 (1-3 ),138-44

Shin, Soona; Wakabayashi, Nobunao; Misra, Vikas; Biswal, Shyam; Lee, Gum Hwa; Agoston, Elin S; Yamamoto, Masayuki; Kensler, Thomas W (2007. )NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis.Molecular and cellular biology, ,27 (20 ),7188-97

Kwak, Mi-Kyoung; Cho, Jeong-Min; Huang, Bo; Shin, Soona; Kensler, Thomas W (2007. )Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells.Free radical biology & medicine, ,43 (5 ),809-17

Choi, Joon-Seok; Shin, Soona; Jin, Ying Hua; Yim, Hyungshin; Koo, Kyo-Tan; Chun, Kwang-Hoon; Oh, You-Take; Lee, Won Hee; Lee, Seung-Ki (2007. )Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis.Apoptosis : an international journal on programmed cell death, ,12 (7 ),1229-41

Jin, Ying Hua; Choi, JoonSeok; Shin, Soona; Lee, Kwang Youl; Park, Jeong Hill; Lee, Seung Ki (2003. )Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells.Carcinogenesis, ,24 (11 ),1767-72

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
CincinnatiĀ  Ohio, 45229
Phone: 513-803-8970