Soona Shin, PhD

Master's Degree: Seoul National University 2004 (Pharmacy)

Doctoral Degree: Johns Hopkins University 2009 (Pharmacology and Molecular Sciences)

Postdoctoral Study: University of Pennsylvania 2012 (Genetics)

Peer Reviewed Publications

Shin, Soona; Wangensteen, Kirk J; Teta-Bissett, Monica; Wang, Yue J; Mosleh-Shirazi, Elham; Buza, Elizabeth L; Greenbaum, Linda E; Kaestner, Klaus H  (2016). Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Hepatology (Baltimore, Md.), 64 (4) , 1163-1177More Information

Aoki, Reina; Shoshkes-Carmel, Michal; Gao, Nan; Shin, Soona; May, Catherine L; Golson, Maria L; Zahm, Adam M; Ray, Michael; Wiser, Caroline L; Wright, Christopher V E; Kaestner, Klaus H  (2016). Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cellular and molecular gastroenterology and hepatology, 2 (2) , 175-188More Information

Shin, Soona; Upadhyay, Naman; Greenbaum, Linda E; Kaestner, Klaus H  (2015). Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology, 148 (1) , 192-202.e3More Information

Shin, Soona; Le Lay, John; Everett, Logan J; Gupta, Rana; Rafiq, Kiran; Kaestner, Klaus H  (2014). CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse ?-cells. Molecular metabolism, 3 (8) , 803-12More Information

Shin, Soona; Kaestner, Klaus H  (2014). The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Current topics in developmental biology, 107, 269-92More Information

Bochkis, Irina Mikhailovna; Shin, Soona; Kaestner, Klaus Hermann  (2013). Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Molecular metabolism, 2 (4) , 447-56More Information

Shin, Soona; Walton, Gabriel; Aoki, Reina; Brondell, Karrie; Schug, Jonathan; Fox, Alan; Smirnova, Olga; Dorrell, Craig; Erker, Laura; Chu, Andrew S; Wells, Rebecca G; Grompe, Markus; Greenbaum, Linda E; Kaestner, Klaus H  (2011). Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes & development, 25 (11) , 1185-92More Information

Lee, Won-Hee; Choi, Joon-Seok; Byun, Mi-Ran; Koo, Kyo-Tan; Shin, Soona; Lee, Seung-Ki; Surh, Young-Joon  (2010). Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2. Toxicology, 278 (2) , 224-8More Information

Wakabayashi, Nobunao; Slocum, Stephen L; Skoko, John J; Shin, Soona; Kensler, Thomas W  (2010). When NRF2 talks, who's listening?. Antioxidants & redox signaling, 13 (11) , 1649-63More Information

Wakabayashi, Nobunao; Shin, Soona; Slocum, Stephen L; Agoston, Elin S; Wakabayashi, Junko; Kwak, Mi-Kyoung; Misra, Vikas; Biswal, Shyam; Yamamoto, Masayuki; Kensler, Thomas W  (2010). Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Science signaling, 3 (130) , ra52More Information

Sackett, Sara D; Gao, Yan; Shin, Soona; Esterson, Yonah B; Tsingalia, Akivaga; Hurtt, Reginald S; Brondell, Karrie; Kaestner, Klaus H; Greenbaum, Linda E  (2009). Foxl1 promotes liver repair following cholestatic injury in mice. Laboratory investigation; a journal of technical methods and pathology, 89 (12) , 1387-96More Information

Shin, Soona; Wakabayashi, Junko; Yates, Melinda S; Wakabayashi, Nobunao; Dolan, Patrick M; Aja, Susan; Liby, Karen T; Sporn, Michael B; Yamamoto, Masayuki; Kensler, Thomas W  (2009). Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European journal of pharmacology, 620 (1-3) , 138-44More Information

Shin, Soona; Wakabayashi, Nobunao; Misra, Vikas; Biswal, Shyam; Lee, Gum Hwa; Agoston, Elin S; Yamamoto, Masayuki; Kensler, Thomas W  (2007). NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and cellular biology, 27 (20) , 7188-97More Information

Kwak, Mi-Kyoung; Cho, Jeong-Min; Huang, Bo; Shin, Soona; Kensler, Thomas W  (2007). Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free radical biology & medicine, 43 (5) , 809-17More Information

Choi, Joon-Seok; Shin, Soona; Jin, Ying Hua; Yim, Hyungshin; Koo, Kyo-Tan; Chun, Kwang-Hoon; Oh, You-Take; Lee, Won Hee; Lee, Seung-Ki  (2007). Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. Apoptosis : an international journal on programmed cell death, 12 (7) , 1229-41More Information

Jin, Ying Hua; Choi, JoonSeok; Shin, Soona; Lee, Kwang Youl; Park, Jeong Hill; Lee, Seung Ki  (2003). Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells. Carcinogenesis, 24 (11) , 1767-72More Information

Rivas, Maria; Johnston, Michael E; Gulati, Ruhi; Kumbaji, Meenasri; Margues Aguiar, Talita Ferreira; Timchenko, Lubov; Krepischi, Ana; Shin, Soona; Bondoc, Alexander; Tiao, Gregory; Geller, James; Timchenko, Nikolai  (2021). HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer. Cellular and molecular gastroenterology and hepatologyMore Information

Lee, Sanghoon; Zhou, Ping; Whyte, Senyo; Shin, Soona  (2020). Adeno-Associated Virus Serotype 8-Mediated Genetic Labeling of Cholangiocytes in the Neonatal Murine Liver. Pharmaceutics, 12 (4) More Information

Lee, Sanghoon; Zhou, Ping; Gupta, Anita; Shin, Soona  (2018). Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Hepatology communications, 2 (10) , 1199-1212More Information

D'Souza, Amber M; Jiang, Yanjun; Cast, Ashley; Valanejad, Leila; Wright, Mary; Lewis, Kyle; Kumbaji, Meenasri; Shah, Sheeniza; Smithrud, David; Karns, Rebekah; Shin, Soona; Timchenko, Nikolai  (2018). Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. Cellular and molecular gastroenterology and hepatology, 6 (3) , 239-255More Information

Cast, Ashley; Valanejad, Leila; Wright, Mary; Nguyen, Phuong; Gupta, Anita; Zhu, Liqin; Shin, Soona; Timchenko, Nikolai  (2018). C/EBP?-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Hepatology (Baltimore, Md.), 67 (5) , 1857-1871More Information

Whyte, Senyo S; Karns, Rebekah; Min, Kyung-Won; Cho, Jung-Hyun; Lee, Sanghoon; Lake, Charissa; Bondoc, Alexander; Yoon, Je-Hyun; Shin, Soona  (2023). Integrated analysis using ToppMiR uncovers altered miRNA- mRNA regulatory networks in pediatric hepatocellular carcinoma-A pilot study. Cancer reports (Hoboken, N.J.), 6 (1) , e1685More Information

Fan, Li; Pan, Qingfei; Yang, Wentao; Koo, Selene C; Tian, Cheng; Li, Liyuan; Lu, Meifen; Brown, Anthony; Ju, Bensheng; Easton, John; Ranganathan, Sarangarajan; Shin, Soona; Bondoc, Alexander; Yang, Jun J; Yu, Jiyang; Zhu, Liqin  (2022). A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis. Hepatology (Baltimore, Md.), 76 (5) , 1275-1290More Information

Gulati, Ruhi; Johnston, Michael; Rivas, Maria; Cast, Ashley; Kumbaji, Meenasri; Hanlon, Margaret A; Lee, Sanghoon; Zhou, Ping; Lake, Charissa; Schepers, Emily; Min, Kyung-Won; Yoon, Je-Hyun; Karns, Rebekah; Reid, Lola M; Lopez-Terrada, Dolores; Timchenko, Lubov; Parameswaran, Sreeja; Weirauch, Matthew T; Ranganathan, Sarangarajan; Bondoc, Alexander; Geller, James; Tiao, Gregory; Shin, Soona; Timchenko, Nikolai  (2022). β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Hepatology communications, 6 (10) , 2950-2963More Information

Lee, Sanghoon; Karns, Rebekah; Shin, Soona  (2022). Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells. Cellular signalling, 100, 110458More Information

Holczbauer, Ágnes; Wangensteen, Kirk J; Shin, Soona  (2022). Cellular origins of regenerating liver and hepatocellular carcinoma. JHEP reports : innovation in hepatology, 4 (4) , 100416More Information

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati  Ohio, 45229
Phone: 513-803-8970
soona.shin@cchmc.org