Wei Shi, PhD

Research interests:

• Define lung mesenchymal progenitor cell heterogeneity and their roles in lung development and injury repair.
• Dissect TGF-beta and BMP signaling mechanisms in lung epithelial vs. mesenchymal compartment and determine their roles in lung development and neonatal respiratory diseases.
• Determine mesenchymal growth factor signaling in controlling lung injury repair and pulmonary fibrosis
• Determine the roles of airway smooth muscle cells in controlling branching morphogenesis during development and their relationship to congenital pulmonary airway malformation.
• Define the origins of pulmonary vascular cells and their contributions to pulmonary circulation establishment. 
• Establish the animal model of lymphangioleimyomatosis (LAM) and study the pathogenic mechanisms underlying the disease.
• Establish a new animal model to study the pathogenic mechanisms of pulmonary cystic lesions in Birt-Hogg-Dubé (BHD) syndrome.

PhD: University of Tennessee Memphis, TN, 1997 (Cell and Molecular Pathology )

Master of Medicine: Shanghai Second Medical University Shanghai (China), 1989 (Medicine)

Bachelor of Medicine: Zhejiang Medical University Hangzhou (China) , 1984 (Medicine)

Grant: #HL141352 Investigators:Shi, Wei 10-01-2022 -01-31-2023 National Heart, Lung and Blood Institute Molecular mechanisms of pulmonary disease in Birt-Hogg-Dube syndrome Role:PI 126259.56 Hold Level:Federal

Grant: #HL146541 Investigators:Shi, Wei 10-01-2022 -03-31-2023 National Heart, Lung and Blood Institute Pathogenic Mechanisms of Pulmonary Lymphangioleiomyomatosis Role:PI 228994.60 Hold Level:Federal

Grant: #R01HL151699 Investigators:Shi, Wei 10-01-2022 -01-31-2026 National Heart, Lung and Blood Institute Lung Development and Diseases Role:PI 388505.17 Hold Level:Federal

Grant: #000013939-B / W81XWH-21-1-0257 Investigators:Shi, Wei 10-01-2022 -04-14-2024 Department of the Army Medical Research Acquisition Activity Mesenchymal Folliculin Defects as a Novel Pathogenic Mechanism of Polycystic Kidney Lesions Role:PI 74000.00 Hold Level:Federal

Grant: #R01ES034490 Investigators:Leikauf, George; Medvedovic, Mario; Shi, Wei 08-20-2023 -07-31-2026 National Institute of Environmental Health Sciences Pathoplysicologic mechansims of e-cigarette-induced chronic obstructive pulmonary disease Role:Collaborator 1467044.00 Awarded Level:Federal

Investigators:Shi, Wei 05-01-2024 -04-30-2026 Department of the Army Medical Research Acquisition Activity Characterization of novel perivascular lesions caused by specific deletion of Tsc2 in hematopoietic cells. Role:PI 0.00 Hold Level:Federal

Grant: #Ann Theodore Foundation Breakthrough Sarcoidosis Initiative Investigators:Gupta, Nishant; Shi, Wei 06-15-2024 -06-15-2026 Milken Institute Abnormal lysosomes in pulmonary sarcoidosis pathogenesis Role:PI 575000.00 Hold Level:Non Profit

Peer Reviewed Publications

Luo, Xiaojin; Shi, Weihua; Yu, Haoming; Xie, Zhaoyang; Li, Kunyi; Cui, Yue (2018. ) Wearable Carbon Nanotube-Based Biosensors on Gloves for Lactate.Sensors (Basel, Switzerland), , 18 (10 ) , More Information

Luo, Yongfeng; Cao, Ke; Chiu, Joanne; Chen, Hui; Wang, Hong-Jun; Thornton, Matthew E; Grubbs, Brendan H; Kolb, Martin; Parmacek, Michael S; Mishina, Yuji; Shi, Wei (2024. ) Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts.bioRxiv : the preprint server for biology, , More Information

Alber, Andrea B; Marquez, Hector A; Ma, Liang; Kwong, George; Thapa, Bibek R; Villacorta-Martin, Carlos; Lindstrom-Vautrin, Jonathan; Bawa, Pushpinder; Wang, Feiya; Luo, Yongfeng; Ikonomou, Laertis; Shi, Wei; Kotton, Darrell N (2023. ) Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme.Nature communications, , 14 (1 ) ,3488 More Information

Yanagihara, Toyoshi; Zhou, Quan; Tsubouchi, Kazuya; Revill, Spencer; Ayoub, Anmar; Gholiof, Mahsa; Chong, Sy Giin; Dvorkin-Gheva, Anna; Ask, Kjetil; Shi, Wei; Kolb, Martin Rj (2023. ) Intrinsic BMP inhibitor Gremlin regulates alveolar epithelial type II cell proliferation and differentiation.Biochemical and biophysical research communications, , 656 ,53-62 More Information

Yang, Qin; Miao, Qing; Chen, Hui; Li, Duo; Luo, Yongfeng; Chiu, Joanne; Wang, Hong-Jun; Chuvanjyan, Michael; Parmacek, Michael S; Shi, Wei (2023. ) Myocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury.The Journal of pathology, , 259 (3 ) ,331-341 More Information

Book Chapter

Warburton D, Chen C, Shi W. (2006 ) Lung development Chronic Obstructive Pulmonary Disease, A Practical Guild to Management .(pp. 319).Oxford, UK, Blackwell Publishing,

Warburton D, Bellusci S, Del Moral P, DeLanghe S, Kaartinen V, Lee M, Tefft D, Shi, W (2006 ) Cell signaling and growth factors in lung development Cell signaling and growth factors in lung development .(pp. 791).Weinheim, Germany, Wiley-VCH

Warburton D, Shi W, Kolb M, Gauldie J. (2008 ) Transforming growth factor-beta peptide signaling in pulmonary development, bronchopulmonary dysplasia, fibrosis, and emphysema Cancer Drug Discovery and Development. Vol 1 .(pp. 621).Totowa, NJ 07512-1165 USA, , Humana Press Inc.

Warburton D, Shi W (2009 ) Genetic mechanisms of lung development and bronchopulmonary dysplasia: an integrative view. Lung Biology in Health and Disease Bronchopulmonary dysplasia .(pp. 1).New York, U.S.A, Informa Helathcare USA, Inc

Shi W (2015 ) Lung mesenchymal stem cells. Stem Cells, Tissue Engineering and Regenerative Medicine .(pp. 331 -336).Singapore, World Scientific Publishing Co. Pte. Ltd

Shi W and Luo Y (2019 ) The origin of stem cells in the developing lung , Encyclopedia of Tissue Engineering and Regenerative Medicine, Vol. 2 .(pp. 313 -318).Academic Press: Elsevier