Yukitaka Shizukuda

Medical Degree: Sapporo Medical University 1986

Internship: SUNY Health Science Center at Brooklyn 1993 (Internal Medicine )

Residency: SUNY Health Science Center at Brooklyn 1995 (Internal Medicine )

Research Fellowship: University of North Texas Health Science Center 1992 (Physiology )

Clinical Cardiology Fellowship : Albert Einstein College of Medicine 1999 (Cardiology )

Molecular Cardiology Fellowship : Albert Einstein College of Medicine 1999 (Cardiology)

Pathophysiology of Cardiovascular Effects of Iron Overload, Hypertrophic Cardiomyopathy, Exercise Physiology.

Peer Reviewed Publications

Bhatti, Sabha; Hakeem, Abdul; Yousuf, Mian Atif; Al-Khalidi, Hussein R; Mazur, Wojciech; Shizukuda, Yukitaka  (2011). Diagnostic performance of computed tomography angiography for differentiating ischemic vs nonischemic cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 18 (3) , 407-20More Information

Abdul-Waheed, Mohammad; Yousuf, Mian; Kelly, Stephanie J; Arena, Ross; Ying, Jun; Naz, Tehmina; Dunlap, Stephanie H; Shizukuda, Yukitaka  (2010). Does left atrial volume affect exercise capacity of heart transplant recipients?. Journal of cardiothoracic surgery, 5, 113More Information

Shizukuda, Yukitaka; Bhatti, Sabha; Munjal, Jitender; Hu, Yuhing L; Harrelson, Allan  (2010). Personalized echocardiography: clinical applications of advanced echocardiography and future directions. Future cardiology, 6 (6) , 833-44More Information

Gujja, Pradeep; Rosing, Douglas R; Tripodi, Dorothy J; Shizukuda, Yukitaka  (2010). Iron overload cardiomyopathy: better understanding of an increasing disorder. Journal of the American College of Cardiology, 56 (13) , 1001-12More Information

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka  (2010). Characteristics of exercise-induced intrapulmonary arteriovenous fistula in patients with unexplained exertional dyspnea. Echocardiography (Mount Kisco, N.Y.), 27 (8) , 908-13More Information

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka  (2010). Characteristics of Exercise-Induced Intrapulmonary Arteriovenous Fistula in Patients with Unexplained Exertional Dyspnea. Echocardiography (Mount Kisco, N.Y.)More Information

Shizukuda, Yukitaka; Plummer, Sandra L; Harrelson, Allan  (2010). Customized exercise echocardiography: beyond detection of coronary artery disease. Echocardiography (Mount Kisco, N.Y.), 27 (2) , 186-94More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Sachdev, Vandana; Nguyen, Tammy T; Botello, Gilberto; Yau, Yu-Ying; Sidenko, Stanislav; Inez, Ernst; Ali, Mir I; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R  (2009). Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis?. Echocardiography (Mount Kisco, N.Y.), 26 (10) , 1153-8More Information

Singhal, Shalabh; Yousuf, Mian A; Weintraub, Neal L; Shizukuda, Yukitaka  (2009). Use of bicycle exercise echocardiography for unexplained exertional dyspnea. Clinical cardiology, 32 (6) , 302-6More Information

Harrelson, Allan; Shizukuda, Yukitaka  (2009). Left ventricular volume with three-dimensional echocardiography: all vendors the same?. Echocardiography (Mount Kisco, N.Y.), 26 (5) , 622; author reply 62More Information

Rahman, Shahid; Abdul-Waheed, Mohammed; Helmy, Tarek; Huffman, Lynn C; Koshal, Vipin; Guitron, Julian; Merrill, Walter H; Lewis, David F; Dunlap, Stephanie; Shizukuda, Yukitaka; Weintraub, Neal L; Meyer, Christopher; Cilingiroglu, Mehmet  (2009). Spontaneous left main coronary artery dissection complicated by pseudoaneurysm formation in pregnancy: role of CT coronary angiography. Journal of cardiothoracic surgery, 4, 15More Information

Taveira-DaSilva, Angelo M; Hathaway, Olanda M; Sachdev, Vandana; Shizukuda, Yukitaka; Birdsall, Charles W; Moss, Joel  (2007). Pulmonary artery pressure in lymphangioleiomyomatosis: an echocardiographic study. Chest, 132 (5) , 1573-8More Information

Arena, Ross; Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas RHeart rate recovery is lower following supine exercise in asymptomatic hereditary hemochromatosis subjects compared with healthy controls. Journal of cardiopulmonary rehabilitation and prevention, 27 (3) , 157-60More Information

Shizukuda, Yukitaka; Bolan, Charles D; Nguyen, Tammy T; Botello, Gilberto; Tripodi, Dorothy J; Yau, Yu-Ying; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R  (2007). Oxidative stress in asymptomatic subjects with hereditary hemochromatosis. American journal of hematology, 82 (3) , 249-50More Information

Sachdev, Vandana; Machado, Roberto F; Shizukuda, Yukitaka; Rao, Yesoda N; Sidenko, Stanislav; Ernst, Inez; St Peter, Marilyn; Coles, Wynona A; Rosing, Douglas R; Blackwelder, William C; Castro, Oswaldo; Kato, Gregory J; Gladwin, Mark T  (2007). Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease. Journal of the American College of Cardiology, 49 (4) , 472-9More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Arena, Ross; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R  (2007). Exercise capacity of cardiac asymptomatic hereditary hemochromatosis subjects. Medicine and science in sports and exercise, 39 (1) , 3-7More Information

Shizukuda, Yukitaka; Tripodi, Dorothy J; Smith, Kevin P; Arena, Ross; Waclawiw, Myron A; Rosing, Douglas R  (2006). Can we use heart rate recovery information generated by supine ergometry exercise?. The American journal of cardiology, 98 (9) , 1297-8More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Nguyen, Tammy T; Botello, Gilberto; Sachdev, Vandana; Sidenko, Stanislav; Ernst, Inez; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R  (2006). Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis. The American journal of cardiology, 98 (7) , 954-9More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Sachdev, Vandana; Birdsall, Charles W; Sidenko, Stanislav; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R  (2006). Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosis. The American journal of cardiology, 98 (5) , 694-8More Information

Sachdev, Vandana; Aletras, Anthony H; Padmanabhan, Sriram; Sidenko, Stanislav; Rao, Yesoda N; Brenneman, Cynthia L; Shizukuda, Yukitaka; Lie, Glenn R; Vincent, Pamela S; Waclawiw, Myron A; Arai, Andrew E  (2006). Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 19 (1) , 34-9More Information

Shizukuda, Yukitaka; Sachdev, Vandana; Fananapazir, Lameh; Tripodi, Dorothy; Mohiddin, Saidi A; Arai, Andrew E; Waclawiw, Myron A; Plehn, Jonathan FIs functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?. Congestive heart failure (Greenwich, Conn.), 11 (5) , 234-40

Shizukuda, Yukitaka; Matoba, Satoaki; Mian, Omar Y; Nguyen, Tammy; Hwang, Paul M  (2005). Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice. Molecular and cellular biochemistry, 273 (1-2) , 25-32

Sachdev, Vandana; Shizukuda, Yukitaka; Brenneman, Cynthia L; Birdsall, Charles W; Waclawiw, Myron A; Arai, Andrew E; Mohiddin, Saidi A; Tripodi, Dorothy; Fananapazir, Lameh; Plehn, Jonathan F  (2005). Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy. American heart journal, 149 (4) , 730-6More Information

Matoba, Satoaki; Hwang, Paul M; Nguyen, Tammy; Shizukuda, Yukitaka  (2005). Evaluation of pulsed Doppler tissue velocity imaging for assessing systolic function of murine global heart failure. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 18 (2) , 148-54More Information

Shizukuda, Yukitaka; Piekarz, Richard L; Bates, Susan E; Sachdev, Vandana; Finkel, Toren; Rosing, Douglas R  (2005). Effect of a histone deacetylase inhibitor on human cardiac mass. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 19 (1) , 89-90More Information

Gladwin, Mark T; Sachdev, Vandana; Jison, Maria L; Shizukuda, Yukitaka; Plehn, Jonathan F; Minter, Karin; Brown, Bernice; Coles, Wynona A; Nichols, James S; Ernst, Inez; Hunter, Lori A; Blackwelder, William C; Schechter, Alan N; Rodgers, Griffin P; Castro, Oswaldo; Ognibene, Frederick P  (2004). Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. The New England journal of medicine, 350 (9) , 886-95More Information

Patino, Willmar D; Mian, Omar Y; Shizukuda, Yukitaka; Hwang, Paul M  (2003). Current and future applications of SAGE to cardiovascular medicine. Trends in cardiovascular medicine, 13 (4) , 163-8

Shizukuda, Yukitaka; Buttrick, Peter M  (2002). Oxygen free radicals and heart failure: new insight into an old question. American journal of physiology. Lung cellular and molecular physiology, 283 (2) , L237-8More Information

Shizukuda, Yukitaka; Buttrick, Peter M  (2002). Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. Journal of molecular and cellular cardiology, 34 (7) , 823-31

Shizukuda, Yukitaka; Reyland, Mary E; Buttrick, Peter M  (2002). Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. American journal of physiology. Heart and circulatory physiology, 282 (5) , H1625-34More Information

Shizukuda, Yukitaka; Buttrick, Peter M  (2002). Isoprotrenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation, 105 (2) , E9

Shizukuda, Yukitaka; Buttrick, Peter M  (2002). Coronary flow reserve or brachial artery flow to assess endothelial dysfunction: is it time to look at the heart again?. The American journal of cardiology, 89 (1) , 113

Shizukuda, Yukitaka; Buttrick, Peter M  (2002). Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. American journal of physiology. Heart and circulatory physiology, 282 (1) , H320-7

Shizukuda, Y; Buttrick, P M  (2001). Protein kinase C(epsilon) modulates apoptosis induced by beta -adrenergic stimulation in adult rat ventricular myocytes via extracellular signal-regulated kinase (ERK) activity. Journal of molecular and cellular cardiology, 33 (10) , 1791-803More Information

Shizukuda, Y; Helisch, A; Yokota, R; Ware, J A  (1999). Downregulation of protein kinase cdelta activity enhances endothelial cell adaptation to hypoxia. Circulation, 100 (18) , 1909-16

Shizukuda, Y; Sonnenblick, E H; Le Jemtel, T H; Forman, RCoronary flow reserve of nonischemic heart failure. Congestive heart failure (Greenwich, Conn.), 5 (5) , 208-215

Shizukuda, Y; Tang, S; Yokota, R; Ware, J A  (1999). Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity. Circulation research, 85 (3) , 247-56

Shizukuda, Y; Buttrick, P M; Geenen, D L; Borczuk, A C; Kitsis, R N; Sonnenblick, E H  (1998). beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. The American journal of physiology, 275 (3 Pt 2) , H961-8

Shizukuda, Y; Iwamoto, T; Mallet, R T; Downey, H F  (1993). Hypoxic preconditioning attenuates stunning caused by repeated coronary artery occlusions in dog heart. Cardiovascular research, 27 (4) , 559-64

Shizukuda, Y; Mallet, R T; Lee, S C; Downey, H F  (1992). Hypoxic preconditioning of ischaemic canine myocardium. Cardiovascular research, 26 (5) , 534-42

Lee, S C; Mallet, R T; Shizukuda, Y; Williams, A G; Downey, H F  (1992). Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. The American journal of physiology, 262 (4 Pt 2) , H955-60

Shizukuda, Y; Miura, T; Ishimoto, R; Itoya, M; Iimura, O  (1991). Effect of prednisolone on myocardial infarct healing: characteristics and comparison with indomethacin. The Canadian journal of cardiology, 7 (10) , 447-54

Miura, T; Shizukuda, Y; Ogawa, S; Ishimoto, R; Iimura, O  (1991). Effects of early and later reperfusion on healing speed of experimental myocardial infarct. The Canadian journal of cardiology, 7 (3) , 146-54

Ooiwa, H; Miura, T; Downey, J M; Matsuki, T; Shizukuda, Y; Adachi, T; Tsuchida, A; Iwamoto, T; Ogawa, T; Iimura, O  (1989). The effect of inotropic dose of dobutamine during reperfusion on myocardial infarct size. Japanese circulation journal, 53 (12) , 1511-20

Matsuda, K; Shimamoto, K; Ura, N; Ogata, H; Shizukuda, Y; Iwakura, M; Nozawa, A; Kikuchi, K; Iimura, O  (1989). A case of primary aldosteronism with chronic renal failure undergoing hemodialysis treatment. Endocrinologia japonica, 36 (5) , 681-6

Miura, T; Downey, J M; Ooiwa, H; Ogawa, S; Adachi, T; Noto, T; Shizukuda, Y; Iimura, O  (1989). Progression of myocardial infarction in a collateral flow deficient species. Japanese heart journal, 30 (5) , 695-708

Miura, T; Ogawa, S; Ooiwa, H; Adachi, T; Noto, T; Shizukuda, Y; Iimura, O  (1989). Human superoxide dismutase failed to limit the size of myocardial infarct after 20-, 30-, or 60-minute ischemia and 72-hour reperfusion in the rabbit. Japanese circulation journal, 53 (7) , 786-94

Shizukuda, Y; Yonekura, S; Tsuchihashi, K; Tanaka, S; Komatsu, S; Iimura, OA case of a right coronary artery to left ventricle fistula observed over twenty years. Japanese journal of medicine, 28 (4) , 510-4

Shizukuda, Y; Tsuchihashi, K; Ogata, H; Hikita, N; Kamei, F; Yonekura, S; Hashimoto, A; Tanaka, S; Iimura, O; Hamagami, Y  (1989). [A case of intra-ventricular dissociation with dual ventricular tachycardia]. Kokyu to junkan. Respiration & circulation, 37 (5) , 579-83

Shizukuda, Y; Murakami, H; Iwakura, M; Hashimoto, A; Tsuchihashi, K; Yonekura, S; Tanaka, S; Shimamoto, K; Sato, M; Iimura, O  (1988). Siblings with left ventricular diverticulum and hypertrophic cardiomyopathy. Journal of cardiology, 18 (3) , 867-74

Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M  (2013). Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis. American journal of respiratory and critical care medicine, 188 (9) , 1167-70More Information

Ahmad, Saad; Bhatti, Sabha; Shizukuda, Yukitaka  (2013). Functional assessment of donor and recipient left atrium in heart transplant patients using full-volume three-dimensional echocardiography. Echocardiography (Mount Kisco, N.Y.), 30 (2) , 191-5More Information

Shizukuda, Yukitaka; Muth, James; Chaney, Curtis; Attari, MehranAnomalous ridge on the left atrial side of the atrial septum. Annals of cardiac anaesthesia, 15 (2) , 161-2More Information

echocardiography, exercise, physiology

Academic - Medical Sciences Building
231 Albert Sabin Way, ML 0542
Cincinnati  Ohio, 45267
Phone: 513-558-4272
Fax: 513-558-6899
yukitaka.shizukuda@uc.edu