Yukitaka Shizukuda

Medical Degree: Sapporo Medical University 1986

Internship: SUNY Health Science Center at Brooklyn 1993 (Internal Medicine )

Residency: SUNY Health Science Center at Brooklyn 1995 (Internal Medicine )

Research Fellowship: University of North Texas Health Science Center 1992 (Physiology )

Clinical Cardiology Fellowship : Albert Einstein College of Medicine 1999 (Cardiology )

Molecular Cardiology Fellowship : Albert Einstein College of Medicine 1999 (Cardiology)

Pathophysiology of Cardiovascular Effects of Iron Overload, Hypertrophic Cardiomyopathy, Exercise Physiology.

Peer Reviewed Publications

Bhatti, Sabha; Hakeem, Abdul; Yousuf, Mian Atif; Al-Khalidi, Hussein R; Mazur, Wojciech; Shizukuda, Yukitaka (2011. ) Diagnostic performance of computed tomography angiography for differentiating ischemic vs nonischemic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, , 18 (3 ) ,407-20 More Information

Abdul-Waheed, Mohammad; Yousuf, Mian; Kelly, Stephanie J; Arena, Ross; Ying, Jun; Naz, Tehmina; Dunlap, Stephanie H; Shizukuda, Yukitaka (2010. ) Does left atrial volume affect exercise capacity of heart transplant recipients?.Journal of cardiothoracic surgery, , 5 ,113 More Information

Shizukuda, Yukitaka; Bhatti, Sabha; Munjal, Jitender; Hu, Yuhing L; Harrelson, Allan (2010. ) Personalized echocardiography: clinical applications of advanced echocardiography and future directions.Future cardiology, , 6 (6 ) ,833-44 More Information

Gujja, Pradeep; Rosing, Douglas R; Tripodi, Dorothy J; Shizukuda, Yukitaka (2010. ) Iron overload cardiomyopathy: better understanding of an increasing disorder.Journal of the American College of Cardiology, , 56 (13 ) ,1001-12 More Information

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka (2010. ) Characteristics of exercise-induced intrapulmonary arteriovenous fistula in patients with unexplained exertional dyspnea.Echocardiography (Mount Kisco, N.Y.), , 27 (8 ) ,908-13 More Information

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka (2010. ) Characteristics of Exercise-Induced Intrapulmonary Arteriovenous Fistula in Patients with Unexplained Exertional Dyspnea.Echocardiography (Mount Kisco, N.Y.), , More Information

Shizukuda, Yukitaka; Plummer, Sandra L; Harrelson, Allan (2010. ) Customized exercise echocardiography: beyond detection of coronary artery disease.Echocardiography (Mount Kisco, N.Y.), , 27 (2 ) ,186-94 More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Sachdev, Vandana; Nguyen, Tammy T; Botello, Gilberto; Yau, Yu-Ying; Sidenko, Stanislav; Inez, Ernst; Ali, Mir I; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R (2009. ) Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis?.Echocardiography (Mount Kisco, N.Y.), , 26 (10 ) ,1153-8 More Information

Singhal, Shalabh; Yousuf, Mian A; Weintraub, Neal L; Shizukuda, Yukitaka (2009. ) Use of bicycle exercise echocardiography for unexplained exertional dyspnea.Clinical cardiology, , 32 (6 ) ,302-6 More Information

Harrelson, Allan; Shizukuda, Yukitaka (2009. ) Left ventricular volume with three-dimensional echocardiography: all vendors the same?.Echocardiography (Mount Kisco, N.Y.), , 26 (5 ) ,622; author reply 62 More Information

Rahman, Shahid; Abdul-Waheed, Mohammed; Helmy, Tarek; Huffman, Lynn C; Koshal, Vipin; Guitron, Julian; Merrill, Walter H; Lewis, David F; Dunlap, Stephanie; Shizukuda, Yukitaka; Weintraub, Neal L; Meyer, Christopher; Cilingiroglu, Mehmet (2009. ) Spontaneous left main coronary artery dissection complicated by pseudoaneurysm formation in pregnancy: role of CT coronary angiography.Journal of cardiothoracic surgery, , 4 ,15 More Information

Taveira-DaSilva, Angelo M; Hathaway, Olanda M; Sachdev, Vandana; Shizukuda, Yukitaka; Birdsall, Charles W; Moss, Joel (2007. ) Pulmonary artery pressure in lymphangioleiomyomatosis: an echocardiographic study.Chest, , 132 (5 ) ,1573-8 More Information

Arena, Ross; Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R Heart rate recovery is lower following supine exercise in asymptomatic hereditary hemochromatosis subjects compared with healthy controls.Journal of cardiopulmonary rehabilitation and prevention, , 27 (3 ) ,157-60 More Information

Shizukuda, Yukitaka; Bolan, Charles D; Nguyen, Tammy T; Botello, Gilberto; Tripodi, Dorothy J; Yau, Yu-Ying; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R (2007. ) Oxidative stress in asymptomatic subjects with hereditary hemochromatosis.American journal of hematology, , 82 (3 ) ,249-50 More Information

Sachdev, Vandana; Machado, Roberto F; Shizukuda, Yukitaka; Rao, Yesoda N; Sidenko, Stanislav; Ernst, Inez; St Peter, Marilyn; Coles, Wynona A; Rosing, Douglas R; Blackwelder, William C; Castro, Oswaldo; Kato, Gregory J; Gladwin, Mark T (2007. ) Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease.Journal of the American College of Cardiology, , 49 (4 ) ,472-9 More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Arena, Ross; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R (2007. ) Exercise capacity of cardiac asymptomatic hereditary hemochromatosis subjects.Medicine and science in sports and exercise, , 39 (1 ) ,3-7 More Information

Shizukuda, Yukitaka; Tripodi, Dorothy J; Smith, Kevin P; Arena, Ross; Waclawiw, Myron A; Rosing, Douglas R (2006. ) Can we use heart rate recovery information generated by supine ergometry exercise?.The American journal of cardiology, , 98 (9 ) ,1297-8 More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Nguyen, Tammy T; Botello, Gilberto; Sachdev, Vandana; Sidenko, Stanislav; Ernst, Inez; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R (2006. ) Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis.The American journal of cardiology, , 98 (7 ) ,954-9 More Information

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Sachdev, Vandana; Birdsall, Charles W; Sidenko, Stanislav; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R (2006. ) Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosis.The American journal of cardiology, , 98 (5 ) ,694-8 More Information

Sachdev, Vandana; Aletras, Anthony H; Padmanabhan, Sriram; Sidenko, Stanislav; Rao, Yesoda N; Brenneman, Cynthia L; Shizukuda, Yukitaka; Lie, Glenn R; Vincent, Pamela S; Waclawiw, Myron A; Arai, Andrew E (2006. ) Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, , 19 (1 ) ,34-9 More Information

Shizukuda, Yukitaka; Sachdev, Vandana; Fananapazir, Lameh; Tripodi, Dorothy; Mohiddin, Saidi A; Arai, Andrew E; Waclawiw, Myron A; Plehn, Jonathan F Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy? .Congestive heart failure (Greenwich, Conn.), , 11 (5 ) ,234-40

Shizukuda, Yukitaka; Matoba, Satoaki; Mian, Omar Y; Nguyen, Tammy; Hwang, Paul M (2005. ) Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice. Molecular and cellular biochemistry, , 273 (1-2 ) ,25-32

Sachdev, Vandana; Shizukuda, Yukitaka; Brenneman, Cynthia L; Birdsall, Charles W; Waclawiw, Myron A; Arai, Andrew E; Mohiddin, Saidi A; Tripodi, Dorothy; Fananapazir, Lameh; Plehn, Jonathan F (2005. ) Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy.American heart journal, , 149 (4 ) ,730-6 More Information

Matoba, Satoaki; Hwang, Paul M; Nguyen, Tammy; Shizukuda, Yukitaka (2005. ) Evaluation of pulsed Doppler tissue velocity imaging for assessing systolic function of murine global heart failure.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, , 18 (2 ) ,148-54 More Information

Shizukuda, Yukitaka; Piekarz, Richard L; Bates, Susan E; Sachdev, Vandana; Finkel, Toren; Rosing, Douglas R (2005. ) Effect of a histone deacetylase inhibitor on human cardiac mass.Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, , 19 (1 ) ,89-90 More Information

Gladwin, Mark T; Sachdev, Vandana; Jison, Maria L; Shizukuda, Yukitaka; Plehn, Jonathan F; Minter, Karin; Brown, Bernice; Coles, Wynona A; Nichols, James S; Ernst, Inez; Hunter, Lori A; Blackwelder, William C; Schechter, Alan N; Rodgers, Griffin P; Castro, Oswaldo; Ognibene, Frederick P (2004. ) Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.The New England journal of medicine, , 350 (9 ) ,886-95 More Information

Patino, Willmar D; Mian, Omar Y; Shizukuda, Yukitaka; Hwang, Paul M (2003. ) Current and future applications of SAGE to cardiovascular medicine. Trends in cardiovascular medicine, , 13 (4 ) ,163-8

Shizukuda, Yukitaka; Buttrick, Peter M (2002. ) Oxygen free radicals and heart failure: new insight into an old question.American journal of physiology. Lung cellular and molecular physiology, , 283 (2 ) ,L237-8 More Information

Shizukuda, Yukitaka; Buttrick, Peter M (2002. ) Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. Journal of molecular and cellular cardiology, , 34 (7 ) ,823-31

Shizukuda, Yukitaka; Reyland, Mary E; Buttrick, Peter M (2002. ) Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes.American journal of physiology. Heart and circulatory physiology, , 282 (5 ) ,H1625-34 More Information

Shizukuda, Yukitaka; Buttrick, Peter M (2002. ) Isoprotrenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation, , 105 (2 ) ,E9

Shizukuda, Yukitaka; Buttrick, Peter M (2002. ) Coronary flow reserve or brachial artery flow to assess endothelial dysfunction: is it time to look at the heart again? .The American journal of cardiology, , 89 (1 ) ,113

Shizukuda, Yukitaka; Buttrick, Peter M (2002. ) Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. American journal of physiology. Heart and circulatory physiology, , 282 (1 ) ,H320-7

Shizukuda, Y; Buttrick, P M (2001. ) Protein kinase C(epsilon) modulates apoptosis induced by beta -adrenergic stimulation in adult rat ventricular myocytes via extracellular signal-regulated kinase (ERK) activity.Journal of molecular and cellular cardiology, , 33 (10 ) ,1791-803 More Information

Shizukuda, Y; Helisch, A; Yokota, R; Ware, J A (1999. ) Downregulation of protein kinase cdelta activity enhances endothelial cell adaptation to hypoxia. Circulation, , 100 (18 ) ,1909-16

Shizukuda, Y; Sonnenblick, E H; Le Jemtel, T H; Forman, R Coronary flow reserve of nonischemic heart failure. Congestive heart failure (Greenwich, Conn.), , 5 (5 ) ,208-215

Shizukuda, Y; Tang, S; Yokota, R; Ware, J A (1999. ) Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity. Circulation research, , 85 (3 ) ,247-56

Shizukuda, Y; Buttrick, P M; Geenen, D L; Borczuk, A C; Kitsis, R N; Sonnenblick, E H (1998. ) beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. The American journal of physiology, , 275 (3 Pt 2 ) ,H961-8

Shizukuda, Y; Iwamoto, T; Mallet, R T; Downey, H F (1993. ) Hypoxic preconditioning attenuates stunning caused by repeated coronary artery occlusions in dog heart. Cardiovascular research, , 27 (4 ) ,559-64

Shizukuda, Y; Mallet, R T; Lee, S C; Downey, H F (1992. ) Hypoxic preconditioning of ischaemic canine myocardium. Cardiovascular research, , 26 (5 ) ,534-42

Lee, S C; Mallet, R T; Shizukuda, Y; Williams, A G; Downey, H F (1992. ) Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. The American journal of physiology, , 262 (4 Pt 2 ) ,H955-60

Shizukuda, Y; Miura, T; Ishimoto, R; Itoya, M; Iimura, O (1991. ) Effect of prednisolone on myocardial infarct healing: characteristics and comparison with indomethacin. The Canadian journal of cardiology, , 7 (10 ) ,447-54

Miura, T; Shizukuda, Y; Ogawa, S; Ishimoto, R; Iimura, O (1991. ) Effects of early and later reperfusion on healing speed of experimental myocardial infarct. The Canadian journal of cardiology, , 7 (3 ) ,146-54

Ooiwa, H; Miura, T; Downey, J M; Matsuki, T; Shizukuda, Y; Adachi, T; Tsuchida, A; Iwamoto, T; Ogawa, T; Iimura, O (1989. ) The effect of inotropic dose of dobutamine during reperfusion on myocardial infarct size. Japanese circulation journal, , 53 (12 ) ,1511-20

Matsuda, K; Shimamoto, K; Ura, N; Ogata, H; Shizukuda, Y; Iwakura, M; Nozawa, A; Kikuchi, K; Iimura, O (1989. ) A case of primary aldosteronism with chronic renal failure undergoing hemodialysis treatment. Endocrinologia japonica, , 36 (5 ) ,681-6

Miura, T; Downey, J M; Ooiwa, H; Ogawa, S; Adachi, T; Noto, T; Shizukuda, Y; Iimura, O (1989. ) Progression of myocardial infarction in a collateral flow deficient species. Japanese heart journal, , 30 (5 ) ,695-708

Miura, T; Ogawa, S; Ooiwa, H; Adachi, T; Noto, T; Shizukuda, Y; Iimura, O (1989. ) Human superoxide dismutase failed to limit the size of myocardial infarct after 20-, 30-, or 60-minute ischemia and 72-hour reperfusion in the rabbit. Japanese circulation journal, , 53 (7 ) ,786-94

Shizukuda, Y; Yonekura, S; Tsuchihashi, K; Tanaka, S; Komatsu, S; Iimura, O A case of a right coronary artery to left ventricle fistula observed over twenty years. Japanese journal of medicine, , 28 (4 ) ,510-4

Shizukuda, Y; Tsuchihashi, K; Ogata, H; Hikita, N; Kamei, F; Yonekura, S; Hashimoto, A; Tanaka, S; Iimura, O; Hamagami, Y (1989. ) [A case of intra-ventricular dissociation with dual ventricular tachycardia]. Kokyu to junkan. Respiration & circulation, , 37 (5 ) ,579-83

Shizukuda, Y; Murakami, H; Iwakura, M; Hashimoto, A; Tsuchihashi, K; Yonekura, S; Tanaka, S; Shimamoto, K; Sato, M; Iimura, O (1988. ) Siblings with left ventricular diverticulum and hypertrophic cardiomyopathy. Journal of cardiology, , 18 (3 ) ,867-74

Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M (2013. ) Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis.American journal of respiratory and critical care medicine, , 188 (9 ) ,1167-70 More Information

Ahmad, Saad; Bhatti, Sabha; Shizukuda, Yukitaka (2013. ) Functional assessment of donor and recipient left atrium in heart transplant patients using full-volume three-dimensional echocardiography.Echocardiography (Mount Kisco, N.Y.), , 30 (2 ) ,191-5 More Information

Shizukuda, Yukitaka; Muth, James; Chaney, Curtis; Attari, Mehran Anomalous ridge on the left atrial side of the atrial septum.Annals of cardiac anaesthesia, , 15 (2 ) ,161-2 More Information

echocardiography, exercise, physiology

Academic - Medical Sciences Building
231 Albert Sabin Way, ML 0542
Cincinnati  Ohio, 45267
Phone: 513-558-4272
Fax: 513-558-6899
yukitaka.shizukuda@uc.edu