Professional Summary
I have a long-term interest in the mechanisms of ion transport and the physiological and pathophysiological processes involving these transporters, which include a variety of P-type ATPases and ion transporters that mediate transepithelial ion fluxes. To develop a comprehensive understanding of their physiological functions we have developed and analyzed a large number of knockout mouse models. These studies have led to important insights regarding the concerted actions of ion transporters on both apical and basolateral membranes of epithelial tissues, revealed major effects on systemic acid-base and electrolyte homeostasis, and contributed to an understanding of their roles in a number of renal, gastrointestinal, cardiac, and skin diseases. These studies are contributing to a better understanding of the cellular and physiological functions of these ion transporters, a number of which serve as important drug receptors, and this in turn is leading to a better understanding of their roles in human disease.
