Luke R Smart, MD

Dr. Smart is a dual-trained hematologist who treats both children and adults with non-cancerous blood disorders. His research focuses on sickle cell disease in sub-Saharan Africa where he collaborates with local faculty to understand the best way to treat sickle cell disease.

Residency: University of Rochester Rochester, NY , 2012 (Internal Medicine and Pediatrics )

Fellowship: Bugando Medical Center Mwanza, Tanzania , 2016 (Global Health )

Fellowship: University of Cincinnati Cincinnati, OH , 2020 (Internal Medicine and Pediatric Hematology Oncology )

Grant: #K23HL153763 Investigators:Smart LR, Ware RE 07-01-2020 -06-30-2025 NIH NHLBI Sickle Cell Anemia, Splenic Pathology, and Hydroxyurea in sub-Saharan Africa Role:PI Active Type:Grant

Grant: #ASH Research Collaborative Data Hub Site Agreement Investigators:Smart, Luke 06-01-2022 -05-31-2023 American Society of Hematology ASH RC Data Hub Sickle Cell Disease Program Role:PI 10000.00 Hold Level:Non Profit

Peer Reviewed Publications

Chami, Neema; Hau, Duncan K; Masoza, Tulla S; Smart, Luke R; Kayange, Neema M; Hokororo, Adolfine; Ambrose, Emmanuela E; Moschovis, Peter P; Wiens, Matthew O; Peck, Robert N  (2019). Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study. PloS one, 14 (6) , e0214563More Information

Mzombwe, Majaliwa; Desderius, Bernard; Kapiga, Saidi; Smart, Luke; Peck, Robert  (2019). The ethical imperative to treat NCDs during research in Africa. The Lancet. Global health, 7 (4) , e406-e407More Information

Tizeba, Yustina A; Mirambo, Mariam M; Kayange, Neema; Mhada, Tumaini; Ambrose, Emmanuela E; Smart, Luke R; Mshana, Stephen E  (2018). Parvovirus B19 Is Associated with a Significant Decrease in Hemoglobin Level among Children <5 Years of Age with Anemia in Northwestern Tanzania. Journal of tropical pediatrics, 64 (6) , 479-487More Information

Hau, Duncan K; Chami, Neema; Duncan, Aynsley; Smart, Luke R; Hokororo, Adolfine; Kayange, Neema M; Peck, Robert N  (2018). Post-hospital mortality in children aged 2-12 years in Tanzania: A prospective cohort study. PloS one, 13 (8) , e0202334More Information

Jaka, Hyasinta; Rhee, Jee Ah; Östlundh, Linda; Smart, Luke; Peck, Robert; Mueller, Andreas; Kasang, Christa; Mshana, Stephen E  (2018). The magnitude of antibiotic resistance to Helicobacter pylori in Africa and identified mutations which confer resistance to antibiotics: systematic review and meta-analysis. BMC infectious diseases, 18 (1) , 193More Information

Smart, Luke R; Ambrose, Emmanuela E; Raphael, Kevin C; Hokororo, Adolfine; Kamugisha, Erasmus; Tyburski, Erika A; Lam, Wilbur A; Ware, Russell E; McGann, Patrick T  (2018). Simultaneous point-of-care detection of anemia and sickle cell disease in Tanzania: the RAPID study. Annals of hematology, 97 (2) , 239-246More Information

Ambrose, Emmanuela E; Makani, Julie; Chami, Neema; Masoza, Tulla; Kabyemera, Rogatus; Peck, Robert N; Kamugisha, Erasmus; Manjurano, Alphaxard; Kayange, Neema; Smart, Luke R  (2018). High birth prevalence of sickle cell disease in Northwestern Tanzania. Pediatric blood & cancer, 65 (1) More Information

Smart, Luke R; Mangat, Halinder S; Issarow, Benson; McClelland, Paul; Mayaya, Gerald; Kanumba, Emmanuel; Gerber, Linda M; Wu, Xian; Peck, Robert N; Ngayomela, Isidore; Fakhar, Malik; Stieg, Philip E; Härtl, Roger  (2017). Severe Traumatic Brain Injury at a Tertiary Referral Center in Tanzania: Epidemiology and Adherence to Brain Trauma Foundation Guidelines. World neurosurgery, 105, 238-248More Information

Marti, Amon I; Colombe, Soledad; Masikini, Peter J; Kalluvya, Samuel E; Smart, Luke R; Wajanga, Bahati M; Jaka, Hyasinta; Peck, Robert N; Downs, Jennifer A  (2017). Increased hepatotoxicity among HIV-infected adults co-infected with Schistosoma mansoni in Tanzania: A cross-sectional study. PLoS neglected tropical diseases, 11 (8) , e0005867More Information

Liwa, Anthony; Roediger, Rebecca; Jaka, Hyasinta; Bougaila, Amina; Smart, Luke; Langwick, Stacey; Peck, Robert  (2017). Herbal and Alternative Medicine Use in Tanzanian Adults Admitted with Hypertension-Related Diseases: A Mixed-Methods Study. International journal of hypertension, 2017, 5692572More Information

Hau, Duncan K; Smart, Luke R; DiPace, Jennifer I; Peck, Robert N  (2017). Global health training among U.S. residency specialties: a systematic literature review. Medical education online, 22 (1) , 1270020More Information

Peck, Robert N; Wang, Richard J; Mtui, Graham; Smart, Luke; Yango, Missana; Elchaki, Rim; Wajanga, Bahati; Downs, Jennifer A; Mteta, Kien; Fitzgerald, Daniel W  (2016). Linkage to Primary Care and Survival After Hospital Discharge for HIV-Infected Adults in Tanzania: A Prospective Cohort Study. Journal of acquired immune deficiency syndromes (1999), 73 (5) , 522-530More Information

Kingery, Justin R; Alfred, Yona; Smart, Luke R; Nash, Emily; Todd, Jim; Naguib, Mostafa R; Downs, Jennifer A; Kalluvya, Samuel; Kataraihya, Johannes B; Peck, Robert N  (2016). Short-term and long-term cardiovascular risk, metabolic syndrome and HIV in Tanzania. Heart (British Cardiac Society), 102 (15) , 1200-5More Information

Smart, Luke R; Orgenes, Neema; Mazigo, Humphrey D; Minde, Mercy; Hokororo, Adolfine; Shakir, Muhammad; Verweij, Jaco J; Downs, Jennifer A; Peck, Robert N  (2016). Malaria and HIV among pediatric inpatients in two Tanzanian referral hospitals: A prospective study. Acta tropica, 159, 36-43More Information

Saidi, Hamza; Smart, Luke R; Kamugisha, Erasmus; Ambrose, Emmanuela E; Soka, Deogratias; Peck, Robert N; Makani, Julie  (2016). Complications of sickle cell anaemia in children in Northwestern Tanzania. Hematology (Amsterdam, Netherlands), 21 (4) , 248-256More Information

Maginga, John; Guerrero, Mariana; Koh, Eileen; Holm Hansen, Christian; Shedafa, Rehema; Kalokola, Fredrick; Smart, Luke R; Peck, Robert N  (2016). Hypertension Control and Its Correlates Among Adults Attending a Hypertension Clinic in Tanzania. Journal of clinical hypertension (Greenwich, Conn.), 18 (3) , 207-16More Information

Manumbu, Sabina; Smart, Luke R; Mwale, Anna; Mate, Kedar S; Downs, Jennifer A  (2015). Shortening Turnaround Times for Newborn HIV Testing in Rural Tanzania: A Report from the Field. PLoS medicine, 12 (11) , e1001897More Information

Maganga, Emmanuel; Smart, Luke R; Kalluvya, Samuel; Kataraihya, Johannes B; Saleh, Ahmed M; Obeid, Lama; Downs, Jennifer A; Fitzgerald, Daniel W; Peck, Robert N  (2015). Glucose Metabolism Disorders, HIV and Antiretroviral Therapy among Tanzanian Adults. PloS one, 10 (8) , e0134410More Information

Kayange, Neema M; Smart, Luke R; Tallman, Jacob E; Chu, Emily Y; Fitzgerald, Daniel W; Pain, Kevin J; Peck, Robert N  (2015). Kidney disease among children in sub-Saharan Africa: systematic review. Pediatric research, 77 (2) , 272-281More Information

Kayange, Neema M; Smart, Luke R; Downs, Jennifer A; Maskini, Mwanaisha; Fitzgerald, Daniel W; Peck, Robert N  (2015). The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. PLoS neglected tropical diseases, 9 (1) , e0003472More Information

Wajanga, Bahati Mk; Webster, Lauren E; Peck, Robert N; Downs, Jennifer A; Mate, Kedar; Smart, Luke R; Fitzgerald, Daniel W  (2014). Inpatient mortality of HIV-infected adults in sub-Saharan Africa and possible interventions: a mixed methods review. BMC health services research, 14, 627More Information

Chofle, Awilly A; Jaka, Hyasinta; Koy, Mheta; Smart, Luke R; Kabangila, Rodrick; Ewings, Fiona M; Mazigo, Humphrey D; Johnson, Warren D; Fitzgerald, Daniel W; Peck, Robert N; Downs, Jennifer A  (2014). Oesophageal varices, schistosomiasis, and mortality among patients admitted with haematemesis in Mwanza, Tanzania: a prospective cohort study. BMC infectious diseases, 14, 303More Information

Liwa, Anthony C; Smart, Luke R; Frumkin, Amara; Epstein, Helen-Ann B; Fitzgerald, Daniel W; Peck, Robert N  (2014). Traditional herbal medicine use among hypertensive patients in sub-Saharan Africa: a systematic review. Current hypertension reports, 16 (6) , 437More Information

Mtwangambate, G; Kalluvya, S E; Kidenya, B R; Kabangila, R; Downs, J A; Smart, L R; Fitzgerald, D W; Peck, R N  (2014). 'Cough-triggered' tuberculosis screening among adults with diabetes in Tanzania. Diabetic medicine : a journal of the British Diabetic Association, 31 (5) , 600-5More Information

Wajanga, Bahati M K; Peck, Robert N; Kalluvya, Samuel; Fitzgerald, Daniel W; Smart, Luke R; Downs, Jennifer A  (2014). Healthcare worker perceived barriers to early initiation of antiretroviral and tuberculosis therapy among Tanzanian inpatients. PloS one, 9 (2) , e87584More Information

Peck, Robert N; Smart, Luke R; Beier, Rita; Liwa, Anthony C; Grosskurth, Heiner; Fitzgerald, Daniel W; Schmidt, Bernhard M W  (2013). Difference in blood pressure response to ACE-Inhibitor monotherapy between black and white adults with arterial hypertension: a meta-analysis of 13 clinical trials. BMC nephrology, 14, 201More Information

Peck, Robert N; Green, Ethan; Mtabaji, Jacob; Majinge, Charles; Smart, Luke R; Downs, Jennifer A; Fitzgerald, Daniel W  (2013). Hypertension-related diseases as a common cause of hospital mortality in Tanzania: a 3-year prospective study. Journal of hypertension, 31 (9) , 1806-11More Information

Janmohamed, Mubarakali N; Kalluvya, Samuel E; Mueller, Andreas; Kabangila, Rodrick; Smart, Luke R; Downs, Jennifer A; Peck, Robert N  (2013). Prevalence of chronic kidney disease in diabetic adult out-patients in Tanzania. BMC nephrology, 14, 183More Information

Eastburg, Luke; Peckham, Andrew; Kawira, Esther; Chirangi, Bwire; Adler, David; Akungo, Brian Dee; Smart, Luke R; Ambrose, Emmanuela E  (2020). Extremely high birth prevalence of sickle cell disease in rural Tanzania. Pediatric blood & cancer, e28620More Information