George Smulian , MD

Dr. Smulian is an investigator recognized for his molecular characterization of Pneumocystis carinii and Histoplasma cell biology with a specific interest in in vivo organism survival.  He is a member of an active clinical research program in anal dysplsia in HIV infected individuals at the Cincinnati VA Medical Center.  In addition to being the Infectious Disease Division Director in the Department of Internal Medicine, he remains chief of the infectious disease section at the Cincinnati VA Medical Center. He is board certified in Internal Medicine and Infectious Diseases and is a Fellow af the American College of Physicians, the Infectious Disease Society of America and the College of Physicians of South Africa. He is an active member of the American Society of Microbiology. He is an ad hoc reviewer for a variety of infectious disease and mycology journals. His published works include approximately 67 articles and fifteen reviews and book chapters.

Residency: University of Witwatersrand 1988 (Internal Medicine)

Fellowship: University of Cincinnati 1991 (Infectious Diseases)

Bachelor of Medicine, Bachelor of Surgery (M.B.B.Ch.): University of the Witwatersrand 1980

Medical Degree: University of the Witwatersrand Medical School Johannesburg, South Africa, 1981

American Board of Internal Medicine (Infectious Disease) (Certification Date: 11-19-1997 ) - (Recertification Date: to 03-24-2024 )

American Board of Internal Medicine (Certification Date: 08-23-1995 ) - (Recertification Date: to 03-24-2024 )

Infectious Disease

Infectious Diseases

Internal Medicine

Antibiotic Stewardship, Mycology, Histoplasma And Pneumocystis

1981 - Intern in Medicine and Surgery, Johannesburg Hospital, Johannesburg, South Africa

1984 -1988 Resident in Internal Medicine, Hillbrow and Johannesburg Hospital, South Africa

1988 -1991 Fellow in Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH

1991 -1992 Instructor in Medicine/Senior Research Fellow, Infectious Disease Division, University of Cincinnati College of Medicine, Cincinnati, OH

1992 -1999 Assistant Professor of Medicine, Infectious Disease Division, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1999 -To Present Associate Professor of Medicine, Infectious Disease Division, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1999 -2000 Director of HIV Service, Staff Physician, Medicine Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH

2000 -To Present Chief, Infectious Disease Section, Medicine Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH

2002 -2009 Associate Director, Infectious Disease Division, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

2009 -2011 Interim Division Director, Infectious Disease Division, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

2004 - Associate Professor with Tenure, University of Cincinnati College of Medicine, Cincinnati, OH

2011 -To Present Ward E Bullock Chair of Infectious Disease,, Division Director, Infectious Disease Division,, University of Cincinnati College of Medicine,, Cincinnati

2012 -To Present Professor of Medicine, University of Cincinnati, Cincinnati, Ohio

04-01-2009 -03-31-2013 Veterans Administration Merit Review Histoplasma gene expression and organism persistence Role:P.I. $631,000

04-01-2009 -03-31-2013 Veterans Administration Merit Review Histoplasma gene expression and organism persistence Role:Principal Investigator 631000 Active Type:Grant

10-01-2008 -09-30-2009 Veterans Administration VISN 10 Research Initiative Program award Histoplama gene expression and organism persistence Role:P.I. $8,333

Grant: #R01 AI52099-01A1 Investigators:F. Finkelman 04-01-2003 -03-31-2009 National Institutes of Health/NIAID Cellular Targets of IL-4 and IL-13 in worm expulsion Role:Co-I. $900,900

07-01-2004 -06-30-2008 Veterans Administration Merit Review Attachment-mediated signaling in Pneumocystis carinii Role:P.I. $900,900

Grant: #P50 NS44283-01 Investigators:E Jauch 09-30-2002 -08-31-2007 National Institutes of Health Spotrias Grant: Recanalization Therapies and Markers of Stroke Outcome Role:Co-I.

10-01-1998 -09-30-2002 Veterans Administration Merit Review Signal transduction in Pneumocystis carinii Role:P.I. $487,900

07-01-1999 -06-30-2004 New Investigator Award in Pathogenic Molecular Mycology, Burroughs Wellcome Fund The role of the MAP kinase, Mkpl, in the regulation of cell wall integrity and synthesis in Pneumocystis carinii $210,000

Grant: #R01 AI44651 Investigators:M. Cushion 02-01-1999 -01-31-2005 National Institutes of Health Pneumocystis Genome Project Role:Co-I.

Investigators:J. Tsevat 05-01-2002 -06-30-2005 Veterans Administration Health Services Research and Development Health Values and Spirituality in Veterans with HIV/AIDS Role:Co-I.

Grant: #R21 AI055338 Investigators:J. Meller 07-01-2003 -Bad Format: 20050631 National Institutes of Health/NIAID Gene Identification and Functional annotation for the Pneumocystis Genome Role:Co-I.

Investigators:P. Walzer 10-1999 -09-2004 Veterans Administration Research Enhancement Award Program (REAP) Role:Co-I.

Grant: #R03 A44646 06-01-1999 -05-31-2001 National Institutes of Health Transformation in Pneumocystis carinii Role:P.I. $100,000

Grant: #R29 AI34759 04-01-1994 -03-31-2000 National Institutes of Health FIRST Award Immunobiology of a Pneumocystis carinii Antigen Role:P.I. $350,000

1997 -1998 University of Cincinnati Department of Internal Medicine Research Challenge Grant Transformation of Pneumocystis carinii Role:P.I. $13,500

09-01-1994 -02-28-1996 University of Cincinnati Research Challenge Grant Mating type genes of Pneumocystis carinii Role:Co-I $50,000

12-01-1993 -11-30-1995 Veterans Affairs RAG Award Characterization of a 55 kDa antigen of Pneumocystis carinii Role:P.I. $34,500

Grant: #1400-50223 03-01-1993 -02-28-1994 Pediatric AIDS Foundation Grant Pneumocystis carinii- serology and pathogenesis Role:P.I. $78,000

Grant: #R03 AI 30323 07-01-1990 -06-30-1991 National Institutes of Health- Division of AIDS Evaluation of Pneumocystis caninii Pneumonia Role:P.I. $65,000

Grant: #SRS 000242 Investigators:Smulian, Alan 07-01-2006 -06-30-2008 Department of Veterans Affairs VA Merit Award Role:PI $77,734.32 Closed Level:Federal

Grant: #5-R21-AI-055338-02-A0-S0-E0 Investigators:Smulian, Alan 08-01-2003 -07-31-2005 National Institute of Allergy and Infectious Diseases Exploring the Pneumocystis Genome: Gene Prediction and Annotation Role:PI $197,060.00 Closed Level:Federal

Grant: #5-R29-AI-34759-05-A0-S0-E0 Investigators:Smulian, Alan 04-01-1994 -03-31-2000 National Institute of Allergy and Infectious Diseases Cell Biology of a Pneumocystis Carinii Antigen Role:PI $439,441.00 Closed Level:Federal

Grant: #5-R03-AI-44646-02-A0-S0-E0 Investigators:Smulian, Alan 06-01-1999 -05-31-2001 National Institute of Allergy and Infectious Diseases Transformation in Pneumocystis Carinii Role:PI $153,000.00 Closed Level:Federal

Grant: #BW993246-03-A0-S0-E0 Investigators:Smulian, Alan 07-01-1999 -06-30-2004 Burroughs Wellcome Fund Role of MAP Kinase Mkp1 in the Regulation of Cell Wall Synthesis in Pneumocystis Carinii Role:PI $210,000.00 Closed Level:Private Non-Profit

Grant: #R21 AR056059 Investigators:Boissy, Raymond; Ip, Wallace; Smulian, Alan 05-01-2008 -04-30-2011 National Institute of Arthritis, Musculoskeletal and Skin Disease The Composition and Function of BLOC-2 in Melanogenesis Role:Collaborator $367,176.00 Closed Level:Federal

Grant: #K23 AI080202 Investigators:Robertson, Jaime; Smulian, Alan; Walzer, Peter 09-15-2008 -08-31-2013 National Institute of Allergy and Infectious Diseases Research Career Development in HIV-Related Anal Dysplasia/Carcinoma Prevention and Treatment Role:Collaborator $580,529.00 Active Level:Federal

Grant: #HHSN2722010000291 Investigators:Cushion, Melanie; Newman, Simon; Rhodes, Judith; Smulian, Alan; Walzer, Peter 03-22-2010 -03-21-2017 National Institute of Allergy and Infectious Diseases Animal Models of Infectious Diseases Role:Collaborator $1,333,752.00 Active Level:Federal

Grant: #ACHN-490-007 Investigators:Smulian, Alan 02-13-2014 -02-12-2015 Biomedical Advanced Research and Development Authority CLINICAL TRIAL AGREEMENT AMONG ACHAOGEN, INC., PPD DEVELOPMENT,LLC AND UNIVERSITY OF CINCINNATI Role:PI $161,089.87 Awarded Level:Federal

Grant: #Duke 225440 EVADE sub UM1AI104681 Investigators:Smulian, Alan 03-26-2018 -11-30-2019 National Institute of Allergy and Infectious Diseases EVADE-A Phase 2 Proof-of-Concept Study to Evaluate the Efficacy and Safety of MED13902 in Mechanically Ventilated Patients for the Prevention of Nosocomial Pneumonia Caused by Pseudomonas aeruginos Role:PI $65,195.16 Awarded Level:Federal

Grant: #Duke 235058 SAATELLITE sub UM1AI104681 Investigators:Smulian, Alan 12-19-2018 -11-30-2019 National Institute of Allergy and Infectious Diseases SAATELLITE - A Phase 2 Randomized, Double-blind, Placebo-controlled, Single-dose, Dose-ranging Study of the Efficacy and Safety of MED14893, a Human Monoclonal Antibody Against Staphylococcus aureus A Role:PI $4,000.00 Awarded Level:Federal

Grant: #1R61AI187113-01 Investigators:; Cushion, Melanie; Smulian, George -11-30-2029 National Institute of Allergy and Infectious Diseases Alveolar organoids and metabolomic-driven cultivation of Pneumocystis species Role:Collaborator 0.00 Hold Level:Federal

Grant: #1R01HL176858 Investigators:; Cushion, Melanie; Smulian, George 09-01-2024 -08-31-2029 National Heart, Lung and Blood Institute Elucidating the Sexual Cycle of HIV/AIDS-Related Pneumocystis Pneumonia Role:Collaborator 0.00 Hold Level:Federal

Grant: #1R61AI187097 Investigators:Cushion, Melanie; Sayson, Steven; Smulian, George -11-30-2029 National Institute of Allergy and Infectious Diseases Development of a Molecular Toolbox for Pneumocystis Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Newman, Simon L; Lemen, Wendy; Smulian, Alan G (2011. ) Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts.Medical mycology : official publication of the International Society for Human and Animal Mycology, , 49 (4 ) ,356-64 More Information

Smulian, A George (2012. ) Invasive models of histoplasmosis.Methods in molecular biology (Clifton, N.J.), , 845 ,519-25 More Information

Rani, Reena; Smulian, Alan G; Greaves, David R; Hogan, Simon P; Herbert, De (2011. ) TGF-B limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.European journal of immunology, , More Information

Rani, Reena; Smulian, Alan G; Greaves, David R; Hogan, Simon P; Herbert, De'Broski R (2011. ) TGF-? limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.European journal of immunology, , 41 (7 ) ,2000-9 More Information

Laskowski, Meggan C; Smulian, Alan G (2010. ) Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum.BMC microbiology, , 10 ,49 More Information

Sesterhenn, Thomas M; Slaven, Bradley E; Keely, Scott P; Smulian, A George; Lang, B Franz; Cushion, Melanie T (2010. ) Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii.Molecular genetics and genomics : MGG, , 283 (1 ) ,63-72 More Information

Perkins, Charles; Yanase, Noriko; Smulian, George; Gildea, Lucy; Orekov, Tatyana; Potter, Crystal; Brombacher, Frank; Aronow, Bruce; Wills-Karp, Marsha; Finkelman, Fred D (2011. ) Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice.The Journal of experimental medicine, , 208 (4 ) ,853-67 More Information

Winters, Michael S; Spellman, Daniel S; Chan, Qilin; Gomez, Francisco J; Hernandez, Margarita; Catron, Brittany; Smulian, Alan G; Neubert, Thomas A; Deepe, George S (2008. ) Histoplasma capsulatum proteome response to decreased iron availability.Proteome science, , 6 ,36 More Information

Hilty, Jeremy; Smulian, A George; Newman, Simon L (2008. ) The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis.Molecular microbiology, , 70 (1 ) ,127-39 More Information

Deepe, George S; Gibbons, Reta S; Smulian, A George (2008. ) Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs.Journal of leukocyte biology, , 84 (3 ) ,669-78 More Information

Smulian, A George; Gibbons, Reta S; Demland, Jeffery A; Spaulding, Deborah T; Deepe, George S (2007. ) Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum.Eukaryotic cell, , 6 (11 ) ,2066-71 More Information

Cushion, Melanie T; Smulian, A George; Slaven, Bradley E; Sesterhenn, Tom; Arnold, Jonathan; Staben, Chuck; Porollo, Aleksey; Adamczak, Rafal; Meller, Jarek (2007. ) Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite.PloS one, , 2 (5 ) ,e423 More Information

Bubnick, Meggan; Smulian, A George (2007. ) The MAT1 locus of Histoplasma capsulatum is responsive in a mating type-specific manner.Eukaryotic cell, , 6 (4 ) ,616-21 More Information

Slaven, Bradley E; Meller, Jaroslaw; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T (2006. ) Draft assembly and annotation of the Pneumocystis carinii genome.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S89-91 More Information

Cushion, Melanie T; Smulian, A George (2006. ) Pneumocystis 2006: summary of the research presented at the ninth International Workshop on Opportunistic Protists.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S80-4 More Information

Sesterhenn, Thomas M; Cushion, Melanie T; Slaven, Bradley E; Smulian, A George (2006. ) Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S154-5 More Information

Slaven, Bradley E; Meller, Jaroslaw; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T (2006. ) Draft assembly and annotation of the Pneumocystis carinii genome.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S89-91 More Information

Slaven, Bradley E; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T; Meller, Jaroslaw (2006. ) Large-scale characterization of introns in the Pneumocystis carinii genome.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S151-3 More Information

Cushion, Melanie T; Smulian, A George (2006. ) Pneumocystis 2006: summary of the research presented at the ninth International Workshop on Opportunistic Protists.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S80-4 More Information

Keely, Scott P; Renauld, Hubert; Wakefield, Ann E; Cushion, Melanie T; Smulian, A George; Fosker, Nigel; Fraser, Audrey; Harris, David; Murphy, Lee; Price, Claire; Quail, Michael A; Seeger, Kathy; Sharp, Sarah; Tindal, Carolyn J; Warren, Tim; Zuiderwijk, Eduard; Barrell, Barclay G; Stringer, James R; Hall, Neil (2005. ) Gene arrays at Pneumocystis carinii telomeres.Genetics, , 170 (4 ) ,1589-600 More Information

Sesterhenn, Thomas M; Cushion, Melanie T; Slaven, Bradley E; Smulian, A George (2006. ) Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S154-5 More Information

Parvatiyar, Kislay; Alsabbagh, Eyad M; Ochsner, Urs A; Stegemeyer, Michelle A; Smulian, Alan G; Hwang, Sung Hei; Jackson, Colin R; McDermott, Timothy R; Hassett, Daniel J (2005. ) Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arsenite.Journal of bacteriology, , 187 (14 ) ,4853-64 More Information

Slaven, Bradley E; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T; Meller, Jaroslaw (2006. ) Large-scale characterization of introns in the Pneumocystis carinii genome.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S151-3 More Information

Wagner, Kenneth R; Dean, Christopher; Beiler, Shauna; Bryan, David W; Packard, Benjamin A; Smulian, A George; Linke, Michael J; de Courten-Myers, Gabrielle M (2005. ) Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability. Current neurovascular research, , 2 (2 ) ,149-55

Keely, Scott P; Renauld, Hubert; Wakefield, Ann E; Cushion, Melanie T; Smulian, A George; Fosker, Nigel; Fraser, Audrey; Harris, David; Murphy, Lee; Price, Claire; Quail, Michael A; Seeger, Kathy; Sharp, Sarah; Tindal, Carolyn J; Warren, Tim; Zuiderwijk, Eduard; Barrell, Barclay G; Stringer, James R; Hall, Neil (2005. ) Gene arrays at Pneumocystis carinii telomeres.Genetics, , 170 (4 ) ,1589-600 More Information

Subauste, Carlos S; Wessendarp, Matthew; Portilllo, Jose-Andres C; Andrade, Rosa M; Hinds, Linda M; Gomez, Francisco J; Smulian, A George; Grubbs, Peter A; Haglund, Lisa A (2004. ) Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients.The Journal of infectious diseases, , 189 (1 ) ,61-70 More Information

Parvatiyar, Kislay; Alsabbagh, Eyad M; Ochsner, Urs A; Stegemeyer, Michelle A; Smulian, Alan G; Hwang, Sung Hei; Jackson, Colin R; McDermott, Timothy R; Hassett, Daniel J (2005. ) Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arsenite.Journal of bacteriology, , 187 (14 ) ,4853-64 More Information

Worsham, D Nicole; Basselin, Mireille; Smulian, A George; Beach, David H; Kaneshiro, Edna S (2003. ) Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT. The Journal of eukaryotic microbiology, , 50 Suppl ,678-9

Wagner, Kenneth R; Dean, Christopher; Beiler, Shauna; Bryan, David W; Packard, Benjamin A; Smulian, A George; Linke, Michael J; de Courten-Myers, Gabrielle M (2005. ) Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability. Current neurovascular research, , 2 (2 ) ,149-55

Sesterhenn, Thomas M; Slaven, Bradley E; Smulian, A George; Cushion, Melanie T (2003. ) Generation of sequencing libraries for the Pneumocystis Genome project. The Journal of eukaryotic microbiology, , 50 Suppl ,663-5

Wilkinson, Deepti S; Ogden, Stacey K; Stratton, Sabrina A; Piechan, Julie L; Nguyen, Thi T; Smulian, George A; Barton, Michelle Craig (2005. ) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene.Molecular and cellular biology, , 25 (3 ) ,1200-12 More Information

Daly, Kieran R; Fichtenbaum, Carl J; Tanaka, Reiko; Linke, Michael J; O'Bert, Robert; Thullen, Timothy D; Hui, Michele S; Smulian, Alan G; Walzer, Peter D (2002. ) Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons.The Journal of infectious diseases, , 186 (5 ) ,644-51 More Information

Subauste, Carlos S; Wessendarp, Matthew; Portilllo, Jose-Andres C; Andrade, Rosa M; Hinds, Linda M; Gomez, Francisco J; Smulian, A George; Grubbs, Peter A; Haglund, Lisa A (2004. ) Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients.The Journal of infectious diseases, , 189 (1 ) ,61-70 More Information

Kaneshiro, Edna S; Rosenfeld, Jill A; Basselin-Eiweida, Mireille; Stringer, James R; Keely, Scott P; Smulian, A George; Giner, José-Luis (2002. ) The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference. Molecular microbiology, , 44 (4 ) ,989-99

Xu, Zheng; Lance, Britton; Vargas, Claudia; Arpinar, Budak; Bhandarkar, Suchendra; Kraemer, Eileen; Kochut, Krys J; Miller, John A; Wagner, Jeff R; Weise, Michael J; Wunderlich, John K; Stringer, James; Smulian, George; Cushion, Melanie T; Arnold, Jonathan (2003. ) Mapping by sequencing the Pneumocystis genome using the ordering DNA sequences V3 tool. Genetics, , 163 (4 ) ,1299-313

Wagner, Kenneth R; Packard, Benjamin A; Hall, Cathy L; Smulian, A George; Linke, Michael J; De Courten-Myers, Gabrielle M; Packard, Lori M; Hall, Nathan C (2002. ) Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma. Developmental neuroscience, , 24 (2-3 ) ,154-60

Worsham, D Nicole; Basselin, Mireille; Smulian, A George; Beach, David H; Kaneshiro, Edna S (2003. ) Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT. The Journal of eukaryotic microbiology, , 50 Suppl ,678-9

Smulian, A G (2001. ) Pneumocystis carinii: genetic diversity and cell biology.Fungal genetics and biology : FG & B, , 34 (3 ) ,145-54 More Information

Sesterhenn, Thomas M; Slaven, Bradley E; Smulian, A George; Cushion, Melanie T (2003. ) Generation of sequencing libraries for the Pneumocystis Genome project. The Journal of eukaryotic microbiology, , 50 Suppl ,663-5

Fox, D; Smulian, A G (2001. ) Plasminogen-binding activity of enolase in the opportunistic pathogen Pneumocystis carinii. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 39 (6 ) ,495-507

Daly, Kieran R; Fichtenbaum, Carl J; Tanaka, Reiko; Linke, Michael J; O'Bert, Robert; Thullen, Timothy D; Hui, Michele S; Smulian, Alan G; Walzer, Peter D (2002. ) Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons.The Journal of infectious diseases, , 186 (5 ) ,644-51 More Information

Subauste, C S; Wessendarp, M; Smulian, A G; Frame, P T (2001. ) Role of CD40 ligand signaling in defective type 1 cytokine response in human immunodeficiency virus infection.The Journal of infectious diseases, , 183 (12 ) ,1722-31 More Information

Kaneshiro, Edna S; Rosenfeld, Jill A; Basselin-Eiweida, Mireille; Stringer, James R; Keely, Scott P; Smulian, A George; Giner, José-Luis (2002. ) The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference. Molecular microbiology, , 44 (4 ) ,989-99

Smulian, A G; Sesterhenn, T; Tanaka, R; Cushion, M T (2001. ) The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes. Genetics, , 157 (3 ) ,991-1002

Wagner, Kenneth R; Packard, Benjamin A; Hall, Cathy L; Smulian, A George; Linke, Michael J; De Courten-Myers, Gabrielle M; Packard, Lori M; Hall, Nathan C (2002. ) Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma. Developmental neuroscience, , 24 (2-3 ) ,154-60

Cushion, M T; Smulian, A G (2001. ) The pneumocystis genome project: update and issues. The Journal of eukaryotic microbiology, , Suppl ,182S-183S

Smulian, A G (2001. ) Pneumocystis carinii: genetic diversity and cell biology.Fungal genetics and biology : FG & B, , 34 (3 ) ,145-54 More Information

Kaneshiro, E S; Rosenfeld, J A; Basselin, M; Bradshaw, S; Stringer, J R; Smulian, A G; Giner, J L (2001. ) Pneumocystis carinii erg6 gene: sequencing and expression of recombinant SAM:sterol methyltransferase in heterologous systems. The Journal of eukaryotic microbiology, , Suppl ,144S-146S

Fox, D; Smulian, A G (2001. ) Plasminogen-binding activity of enolase in the opportunistic pathogen Pneumocystis carinii. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 39 (6 ) ,495-507

Keely, S P; Wakefield, A E; Cushion, M T; Smulian, A G; Hall, N; Barrell, B G; Stringer, J R (2001. ) Detailed structure of Pneumocystis carinii chromosome ends. The Journal of eukaryotic microbiology, , Suppl ,118S-120S

Subauste, C S; Wessendarp, M; Smulian, A G; Frame, P T (2001. ) Role of CD40 ligand signaling in defective type 1 cytokine response in human immunodeficiency virus infection.The Journal of infectious diseases, , 183 (12 ) ,1722-31 More Information

Okuda, M; Horn, H F; Tarapore, P; Tokuyama, Y; Smulian, A G; Chan, P K; Knudsen, E S; Hofmann, I A; Snyder, J D; Bove, K E; Fukasawa, K (2000. ) Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell, , 103 (1 ) ,127-40

Smulian, A G; Sesterhenn, T; Tanaka, R; Cushion, M T (2001. ) The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes. Genetics, , 157 (3 ) ,991-1002

Fox, D; Smulian, A G (2000. ) Mkp1 of Pneumocystis carinii associates with the yeast transcription factor Rlm1 via a mechanism independent of the activation state. Cellular signalling, , 12 (6 ) ,381-90

Cushion, M T; Smulian, A G (2001. ) The pneumocystis genome project: update and issues. The Journal of eukaryotic microbiology, , Suppl ,182S-183S

Smulian, A G; Sullivan, D W; Theus, S A (2000. ) Immunization with recombinant Pneumocystis carinii p55 antigen provides partial protection against infection: characterization of epitope recognition associated with immunization. Microbes and infection / Institut Pasteur, , 2 (2 ) ,127-36

Kaneshiro, E S; Rosenfeld, J A; Basselin, M; Bradshaw, S; Stringer, J R; Smulian, A G; Giner, J L (2001. ) Pneumocystis carinii erg6 gene: sequencing and expression of recombinant SAM:sterol methyltransferase in heterologous systems. The Journal of eukaryotic microbiology, , Suppl ,144S-146S

Fox, D; Smulian, A G (1999. ) Mitogen-activated protein kinase Mkp1 of Pneumocystis carinii complements the slt2Delta defect in the cell integrity pathway of Saccharomyces cerevisiae. Molecular microbiology, , 34 (3 ) ,451-62

Keely, S P; Wakefield, A E; Cushion, M T; Smulian, A G; Hall, N; Barrell, B G; Stringer, J R (2001. ) Detailed structure of Pneumocystis carinii chromosome ends. The Journal of eukaryotic microbiology, , Suppl ,118S-120S

Theus, S A; Smulian, A G; Steele, P; Linke, M J; Walzer, P D (1998. ) Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response. Vaccine, , 16 (11-12 ) ,1149-57

Okuda, M; Horn, H F; Tarapore, P; Tokuyama, Y; Smulian, A G; Chan, P K; Knudsen, E S; Hofmann, I A; Snyder, J D; Bove, K E; Fukasawa, K (2000. ) Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell, , 103 (1 ) ,127-40

Broomall, K R; Morris, R E; Walzer, P D; Smulian, A G Zymolyase treatment exposes p55 antigen of Pneumocystis carinii. The Journal of eukaryotic microbiology, , 45 (3 ) ,284-9

Fox, D; Smulian, A G (2000. ) Mkp1 of Pneumocystis carinii associates with the yeast transcription factor Rlm1 via a mechanism independent of the activation state. Cellular signalling, , 12 (6 ) ,381-90

Theus, S A; Sawhney, N; Smulian, A G; Walzer, P D (1998. ) Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii. The Journal of infectious diseases, , 177 (1 ) ,238-41

Smulian, A G; Sullivan, D W; Theus, S A (2000. ) Immunization with recombinant Pneumocystis carinii p55 antigen provides partial protection against infection: characterization of epitope recognition associated with immunization. Microbes and infection / Institut Pasteur, , 2 (2 ) ,127-36

Smulian, A G Identification of potential Pneumocystis carinii autonomous replication sequences for use in the development of a transformation system. The Journal of eukaryotic microbiology, , 44 (6 ) ,12S

Fox, D; Smulian, A G (1999. ) Mitogen-activated protein kinase Mkp1 of Pneumocystis carinii complements the slt2Delta defect in the cell integrity pathway of Saccharomyces cerevisiae. Molecular microbiology, , 34 (3 ) ,451-62

Broomall, K; Collins, M; Smulian, A G Pneumocystis carinii promoter analysis in a heterologous Saccharomyces cerevisiae assay system. The Journal of eukaryotic microbiology, , 44 (6 ) ,10S-11S

Theus, S A; Smulian, A G; Steele, P; Linke, M J; Walzer, P D (1998. ) Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response. Vaccine, , 16 (11-12 ) ,1149-57

Smulian, A G; Keely, S P; Sunkin, S M; Stringer, J R (1997. ) Genetic and antigenic variation in Pneumocystis carinii organisms: tools for examining the epidemiology and pathogenesis of infection. The Journal of laboratory and clinical medicine, , 130 (5 ) ,461-8

Broomall, K R; Morris, R E; Walzer, P D; Smulian, A G Zymolyase treatment exposes p55 antigen of Pneumocystis carinii. The Journal of eukaryotic microbiology, , 45 (3 ) ,284-9

Cushion, M T; Walzer, P D; Smulian, A G; Linke, M J; Ruffolo, J J; Kaneshiro, E S; Stringer, J R (1997. ) Terminology for the life cycle of Pneumocystis carinii. Infection and immunity, , 65 (10 ) ,4365; author reply 4

Theus, S A; Sawhney, N; Smulian, A G; Walzer, P D (1998. ) Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii. The Journal of infectious diseases, , 177 (1 ) ,238-41

Perlada, D E; Smulian, A G; Cushion, M T (1997. ) Molecular epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey. Journal of clinical microbiology, , 35 (9 ) ,2342-7

Smulian, A G Identification of potential Pneumocystis carinii autonomous replication sequences for use in the development of a transformation system. The Journal of eukaryotic microbiology, , 44 (6 ) ,12S

Theus, S A; Smulian, A G; Sullivan, D W; Walzer, P D (1997. ) Cytokine responses to the native and recombinant forms of the major surface glycoprotein of Pneumocystis carinii. Clinical and experimental immunology, , 109 (2 ) ,255-60

Broomall, K; Collins, M; Smulian, A G Pneumocystis carinii promoter analysis in a heterologous Saccharomyces cerevisiae assay system. The Journal of eukaryotic microbiology, , 44 (6 ) ,10S-11S

Keely, S P; Baughman, R P; Smulian, A G; Dohn, M N; Stringer, J R (1996. ) Source of Pneumocystis carinii in recurrent episodes of pneumonia in AIDS patients. AIDS (London, England), , 10 (8 ) ,881-8

Smulian, A G; Keely, S P; Sunkin, S M; Stringer, J R (1997. ) Genetic and antigenic variation in Pneumocystis carinii organisms: tools for examining the epidemiology and pathogenesis of infection. The Journal of laboratory and clinical medicine, , 130 (5 ) ,461-8

Smulian, A G; Ryan, M; Staben, C; Cushion, M (1996. ) Signal transduction in Pneumocystis carinii: characterization of the genes (pcg1) encoding the alpha subunit of the G protein (PCG1) of Pneumocystis carinii carinii and Pneumocystis carinii ratti. Infection and immunity, , 64 (3 ) ,691-701

Cushion, M T; Walzer, P D; Smulian, A G; Linke, M J; Ruffolo, J J; Kaneshiro, E S; Stringer, J R (1997. ) Terminology for the life cycle of Pneumocystis carinii. Infection and immunity, , 65 (10 ) ,4365; author reply 4

Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T (1996. ) Antigenic differences associated with genetically distinct Pneumocystis carinii from rats. Infection and immunity, , 64 (1 ) ,290-7

Perlada, D E; Smulian, A G; Cushion, M T (1997. ) Molecular epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey. Journal of clinical microbiology, , 35 (9 ) ,2342-7

Keely, S P; Stringer, J R; Baughman, R P; Linke, M J; Walzer, P D; Smulian, A G (1995. ) Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. The Journal of infectious diseases, , 172 (2 ) ,595-8

Theus, S A; Smulian, A G; Sullivan, D W; Walzer, P D (1997. ) Cytokine responses to the native and recombinant forms of the major surface glycoprotein of Pneumocystis carinii. Clinical and experimental immunology, , 109 (2 ) ,255-60

Kralovic, S M; Hutchins, M G; Smulian, A G (1995. ) Pancreatic abscess due to Eikenella corrodens in association with severe ethanolism. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 20 (1 ) ,198-9

Keely, S P; Baughman, R P; Smulian, A G; Dohn, M N; Stringer, J R (1996. ) Source of Pneumocystis carinii in recurrent episodes of pneumonia in AIDS patients. AIDS (London, England), , 10 (8 ) ,881-8

Smulian, A G; Linke, M J; Cushion, M T; Baughman, R P; Frame, P T; Dohn, M N; White, M L; Walzer, P D (1994. ) Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity. AIDS (London, England), , 8 (11 ) ,1555-62

Smulian, A G; Ryan, M; Staben, C; Cushion, M (1996. ) Signal transduction in Pneumocystis carinii: characterization of the genes (pcg1) encoding the alpha subunit of the G protein (PCG1) of Pneumocystis carinii carinii and Pneumocystis carinii ratti. Infection and immunity, , 64 (3 ) ,691-701

Linke, M J; Smulian, A G; Yoshihara, P; Walzer, P D Production and characterization of monoclonal antibodies specific for the major surface glycoprotein of Pneumocystis carinii. The Journal of eukaryotic microbiology, , 41 (5 ) ,99S-100S

Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T (1996. ) Antigenic differences associated with genetically distinct Pneumocystis carinii from rats. Infection and immunity, , 64 (1 ) ,290-7

Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T Antigenic differences among genetically distinct types of rat-derived Pneumocystis carinii. The Journal of eukaryotic microbiology, , 41 (5 ) ,114S

Keely, S P; Stringer, J R; Baughman, R P; Linke, M J; Walzer, P D; Smulian, A G (1995. ) Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. The Journal of infectious diseases, , 172 (2 ) ,595-8

Theus, S A; Sullivan, D W; Walzer, P D; Smulian, A G (1994. ) Cellular responses to a 55-kilodalton recombinant Pneumocystis carinii antigen. Infection and immunity, , 62 (8 ) ,3479-84

Kralovic, S M; Hutchins, M G; Smulian, A G (1995. ) Pancreatic abscess due to Eikenella corrodens in association with severe ethanolism. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 20 (1 ) ,198-9

Smulian, A G; Theus, S A (1994. ) Cellular immune response in Pneumocystis carinii infection. Parasitology today (Personal ed.), , 10 (6 ) ,229-31

Smulian, A G; Linke, M J; Cushion, M T; Baughman, R P; Frame, P T; Dohn, M N; White, M L; Walzer, P D (1994. ) Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity. AIDS (London, England), , 8 (11 ) ,1555-62

Linke, M J; Smulian, A G; Stringer, J R; Walzer, P D (1994. ) Characterization of multiple unique cDNAs encoding the major surface glycoprotein of rat-derived Pneumocystis carinii. Parasitology research, , 80 (6 ) ,478-86

Linke, M J; Smulian, A G; Yoshihara, P; Walzer, P D Production and characterization of monoclonal antibodies specific for the major surface glycoprotein of Pneumocystis carinii. The Journal of eukaryotic microbiology, , 41 (5 ) ,99S-100S

Stringer, J R; Stringer, S L; Zhang, J; Baughman, R; Smulian, A G; Cushion, M T Molecular genetic distinction of Pneumocystis carinii from rats and humans. The Journal of eukaryotic microbiology, , 40 (6 ) ,733-41

Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T Antigenic differences among genetically distinct types of rat-derived Pneumocystis carinii. The Journal of eukaryotic microbiology, , 41 (5 ) ,114S

Smulian, A G; Sullivan, D W; Linke, M J; Halsey, N A; Quinn, T C; MacPhail, A P; Hernandez-Avila, M A; Hong, S T; Walzer, P D (1993. ) Geographic variation in the humoral response to Pneumocystis carinii. The Journal of infectious diseases, , 167 (5 ) ,1243-7

Theus, S A; Sullivan, D W; Walzer, P D; Smulian, A G (1994. ) Cellular responses to a 55-kilodalton recombinant Pneumocystis carinii antigen. Infection and immunity, , 62 (8 ) ,3479-84

Smulian, A G; Theus, S A; Denko, N; Walzer, P D; Stringer, J R (1993. ) A 55 kDa antigen of Pneumocystis carinii: analysis of the cellular immune response and characterization of the gene. Molecular microbiology, , 7 (5 ) ,745-53

Smulian, A G; Theus, S A (1994. ) Cellular immune response in Pneumocystis carinii infection. Parasitology today (Personal ed.), , 10 (6 ) ,229-31

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D (1992. ) Isolation and characterization of a recombinant antigen of Pneumocystis carinii. Infection and immunity, , 60 (3 ) ,907-15

Linke, M J; Smulian, A G; Stringer, J R; Walzer, P D (1994. ) Characterization of multiple unique cDNAs encoding the major surface glycoprotein of rat-derived Pneumocystis carinii. Parasitology research, , 80 (6 ) ,478-86

Smulian, A G; Walzer, P D (1992. ) The biology of Pneumocystis carinii.Critical reviews in microbiology, , 18 (3 ) ,191-216 More Information

Stringer, J R; Stringer, S L; Zhang, J; Baughman, R; Smulian, A G; Cushion, M T Molecular genetic distinction of Pneumocystis carinii from rats and humans. The Journal of eukaryotic microbiology, , 40 (6 ) ,733-41

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D Expression cloning of Pneumocystis carinii antigens. The Journal of protozoology, , 38 (6 ) ,8S-10S

Smulian, A G; Sullivan, D W; Linke, M J; Halsey, N A; Quinn, T C; MacPhail, A P; Hernandez-Avila, M A; Hong, S T; Walzer, P D (1993. ) Geographic variation in the humoral response to Pneumocystis carinii. The Journal of infectious diseases, , 167 (5 ) ,1243-7

Zhang, J X; Cushion, M T; Giuntoli, D; Hong, S T; Meade, J C; Smulian, A G; Stringer, S L; Stringer, J J Analysis of the Pneumocystis carinii genome. The Journal of protozoology, , 38 (6 ) ,69S

Juárez-Figueroa, L A; Hernández-Avila, M; Uribe-Zúñiga, P; Smulian, G [Prevalence of antibodies to Pneumocystis carinii in subjects with high risk behavior for AIDS]. Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición, , 45 (3 ) ,229-31

Dohn, M N; Frame, P T; Baughman, R P; Lafon, S W; Smulian, A G; Caldwell, P; Rogers, M D Open-label efficacy and safety trial of 42 days of 566C80 for Pneumocystis carinii pneumonia in AIDS patients. The Journal of protozoology, , 38 (6 ) ,220S-221S

Smulian, A G; Theus, S A; Denko, N; Walzer, P D; Stringer, J R (1993. ) A 55 kDa antigen of Pneumocystis carinii: analysis of the cellular immune response and characterization of the gene. Molecular microbiology, , 7 (5 ) ,745-53

Peglow, S L; Smulian, A G; Linke, M J; Pogue, C L; Nurre, S; Crisler, J; Phair, J; Gold, J W; Armstrong, D; Walzer, P D (1990. ) Serologic responses to Pneumocystis carinii antigens in health and disease. The Journal of infectious diseases, , 161 (2 ) ,296-306

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D (1992. ) Isolation and characterization of a recombinant antigen of Pneumocystis carinii. Infection and immunity, , 60 (3 ) ,907-15

Smulian, A G; Walzer, P D (1992. ) The biology of Pneumocystis carinii.Critical reviews in microbiology, , 18 (3 ) ,191-216 More Information

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D Expression cloning of Pneumocystis carinii antigens. The Journal of protozoology, , 38 (6 ) ,8S-10S

Holodniy, Mark; Brown, Sheldon T; Cameron, D William; Kyriakides, Tassos C; Angus, Brian; Babiker, Abdel; Singer, Joel; Owens, Douglas K; Anis, Aslam; Goodall, Ruth; Hudson, Fleur; Piaseczny, Mirek; Russo, John; Schechter, Martin; Deyton, Lawrence; Darbyshire, Janet (2011. ) Results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant HIV infection from the OPTIMA trial.PloS one, , 6 (3 ) ,e14764 More Information

Zhang, J X; Cushion, M T; Giuntoli, D; Hong, S T; Meade, J C; Smulian, A G; Stringer, S L; Stringer, J J Analysis of the Pneumocystis carinii genome. The Journal of protozoology, , 38 (6 ) ,69S

Dohn, M N; Frame, P T; Baughman, R P; Lafon, S W; Smulian, A G; Caldwell, P; Rogers, M D Open-label efficacy and safety trial of 42 days of 566C80 for Pneumocystis carinii pneumonia in AIDS patients. The Journal of protozoology, , 38 (6 ) ,220S-221S

Peglow, S L; Smulian, A G; Linke, M J; Pogue, C L; Nurre, S; Crisler, J; Phair, J; Gold, J W; Armstrong, D; Walzer, P D (1990. ) Serologic responses to Pneumocystis carinii antigens in health and disease. The Journal of infectious diseases, , 161 (2 ) ,296-306

Levy, H; Feldman, C; Smulian, G (1987. ) Pulmonary mucormycosis. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, , 71 (4 ) ,265-6

Lewis, M I; Kallenbach, J M; Smulian, G; Bezwoda, W; Zaltzman, M; Derman, D; Zwi, S (1982. ) Complete remission of thrombotic thrombocytopenic purpura following the use of plasma exchange and dipyridamole. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, , 62 (6 ) ,177-8

Newman, Simon L; Smulian, A George (2013. ) Iron uptake and virulence in Histoplasma capsulatum.Current opinion in microbiology, , 16 (6 ) ,700-7 More Information

Laskowski-Peak, Meggan C; Calvo, Ana M; Rohrssen, Jennifer; Smulian, A George (2012. ) VEA1 is required for cleistothecial formation and virulence in Histoplasma capsulatum.Fungal genetics and biology : FG & B, , 49 (10 ) ,838-46 More Information

Dade, Jessica; DuBois, Juwen C; Pasula, Rajamouli; Donnell, Anna M; Caruso, Joseph A; Smulian, A George; Deepe, George S (2016. ) HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo.Medical mycology, , 54 (8 ) ,865-75 More Information

DuBois, Juwen C; Smulian, A George (2016. ) Sterol Regulatory Element Binding Protein (Srb1) Is Required for Hypoxic Adaptation and Virulence in the Dimorphic Fungus Histoplasma capsulatum.PloS one, , 11 (10 ) ,e0163849 More Information

DuBois, Juwen C; Pasula, Rajamouli; Dade, Jessica E; Smulian, A George (2016. ) Yeast Transcriptome and In Vivo Hypoxia Detection Reveals Histoplasma capsulatum Response to Low Oxygen Tension.Medical mycology, , 54 (1 ) ,40-58 More Information

2006 Mark Woolcott Award for Excellence in Clinical Care Delivery, Veterans Health Administration

2001 Medical Mycology Journal Prize, Best Research Article

1999 New Investigator in Molecular Pathogenic Mycology, Burroughs Wellcome Fund

1992 Trainee Investigator Award, American Federation for Clinical Research

1989 National Foundation of Infectious Diseases ICAAC Travel Award

1989 Dean's Award for Clinical Teaching

Humoral Immunity,Cellular Immunity,Pneumocystis Carinii,Pneumocystis Pneumonia,Fluorescence Microscopy,Microorganism Immunology,Host Organism Interaction,Histoplasma capsulatum, Anal carcinoma, HPV

2009 -To Present: Fellow of the Americal College of Physicians

2012 -To Present: Fellow of the Infectious Disease Society of America

1987 -To Present: Fellow of the South African College of Physicians

Academic - Internal Medicine
Medical Sciences Building Room 6104
Cincinnati  Ohio, 45267
Phone: 513-558-4704
Fax: 513-558-2089
alan.smulian@uc.edu