Manoocher Soleimani

Manoocher Soleimani , MD

Emeritus

Professor of Medicine; Associate Chair for Research, Department of Medicine

Internal Medicine
Medical Sciences Building Room G362
231 Albert Sabin Way
Cincinnati, Ohio 45267
Phone 513-558-5471
Fax 513-558-4309
Email manoocher.soleimani@uc.edu

Professional Summary

Research in Dr. Soleimani's laboratory has resulted in the identification of several novels genes that are involved in tissue damage in kidney ischemia. In addition he has identified the major bicarbonate transporter in the duodenum, the first mammalian bicarbonate absorbing transporter in the kidney, as well as 4 other bicarbonate transporters in gastric epithelial cells and kidney tubules.

Education

Medical Degree: Shiraz University School of Medicine 1978

Fellowship: Yale University School of Medicine New Haven, CT, 1988 (Nephrology)

Residency: Shiraz University School of Medicine Shiraz, Iran, 1982 (Internal Medicine)

Certifications

American Board of Internal Medicine (Certification Date: 08-22-2000 ) - (Recertification Date: to 12-31-2010 )

American Board of Internal Medicine (Nephrology) (Certification Date: 10-03-2018 )

Clinical Interests

Nephrology

Research and Practice Interests

Identification, Cloning and Examination of Genes Regulating Acid Base Transport in the Kidney, Salt Absorption in the Kidney Distal Nephron and Blood Pressure Regulation Through the Generation and Examination of Transgenic Mice, Identification and Examination of Genes that Play Important Roles in Either Promoting or Protecting Against Tissue Injury in Kidney Damage

Positions and Work Experience

2000 -To Present Director, Division of Nephrology and Hypertension, University of Cincinnati College of Medicine, Cincinnati, OH

1998 -To Present Professor of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1995 -2000 Director of Research, Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati, OH

1988 -1995 Staff Physician, Veterans Administration Hospital, Indianapolis, IN

1995 -To Present Staff Physician, Veterans Administration Hospital, Cincinnati, OH

1995 -1998 Associate Professor of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1992 -1995 Associate Professor of Medicine, Indiana University School of Medicine,

1988 -1992 Assistant Professor of Medicine, Indiana University School of Medicine,

Research Support

Grant: #1-R21-DK-066589-01-A0-S0-E0 Investigators:Soleimani, Manoocher 01-06-2004 -12-31-2005 National Inst of Diabetes and Digestive and Kidney Disease Polyamine Metabolism in Heart and Kidney Ischemia Injury Role:PI $306,995.00 Closed Level:Federal

Grant: #R01 DK062809 Investigators:Soleimani, Manoocher 01-06-2004 -12-31-2008 National Inst of Diabetes and Digestive and Kidney Disease Apical CL/OH-/HCO3 - Exchangers in Kidney and GI Tract Role:PI $1,500,501.00 Closed Level:Federal

Grant: #CFF-06-02-A0-S0-E0 Investigators:Soleimani, Manoocher 04-01-2000 -03-31-2002 Cystic Fibrosis Foundation Mechanisms of Tracheal Bicarbonate Secretion Defect in Cystic Fibrosis Role:PI $108,712.00 Closed Level:Private Non-Profit

Investigators:Soleimani, Manoocher 04-01-2002 -12-31-2003 Cystic Fibrosis Foundation Regulation of Bicarbonate Transporters in the Pancreatic Duct: The Role of CFTR Role:PI $64,260.00 Closed Level:Private Non-Profit

Grant: #UF07016 / R01 DK056245 Investigators:Lorenz, John; Soleimani, Manoocher 02-01-2007 -01-31-2010 National Inst of Diabetes and Digestive and Kidney Disease Oxalate Handling in PAT1 and DRA Knockout Mice Role:PI $61,063.00 Closed Level:Federal

Grant: #5-R01-DK-52821-04-A0-S0-E0 Investigators:Soleimani, Manoocher 06-08-1998 -05-31-2002 National Inst of Diabetes and Digestive and Kidney Disease Regulation of Colonic H-K-ATPase in the Kidney Role:PI $766,353.00 Closed Level:Federal

Grant: #5-R01-DK-54430-04-A0-S0-E0 Investigators:Soleimani, Manoocher 09-01-1998 -08-31-2002 National Inst of Diabetes and Digestive and Kidney Disease Characterization of NA-Dependent HCO3-Transporters Role:PI $927,478.00 Closed Level:Federal

Grant: #R01 DK079979 Investigators:Montrose, Marshall; Shull, Gary; Soleimani, Manoocher; Worrell, Roger 08-01-2008 -07-31-2014 National Inst of Diabetes and Digestive and Kidney Disease Intestinal epithelial Ammonium Transport Role:Collaborator $1,343,006.00 Active Level:Federal

Grant: #R56 DK062809 Investigators:Amlal, Hassane; Lorenz, John; Soleimani, Manoocher 08-15-2009 -07-31-2010 National Inst of Diabetes and Digestive and Kidney Disease Apical Chloride/Bicarbonate Exchanges in Small Intestine and Kidney Role:PI $460,826.00 Active Level:Federal

Grant: #R01 DK050594 Investigators:Lorenz, John; Shull, Gary; Soleimani, Manoocher; Worrell, Roger 06-01-2010 -03-31-2014 National Inst of Diabetes and Digestive and Kidney Disease Genetic Models for Disorders of Acid-Base Transport Role:Collaborator $1,916,619.00 Active Level:Federal

Grant: #R21 DK091917 Investigators:Kleene, Nancy; Kleene, Steven; Soleimani, Manoocher; Waltz, Susan 07-26-2011 -04-30-2014 National Inst of Diabetes and Digestive and Kidney Disease Chemosensory Transduction in a Primary Cilium Role:Collaborator $431,750.00 Active Level:Federal

Grant: #C-3429 Investigators:Soleimani, Manoocher 07-01-2015 -12-31-2015 Dialysis Clinic, Inc. The Role of Polyamine Catabolic Pathway in Cell Injury: A BAsis for Acute Kidney Damage in Ischemia Reperfusion Injury #C-3429 Role:PI $38,899.00 Awarded Level:Private Non-Profit

Grant: #C-3559 Investigators:Soleimani, Manoocher 07-01-2015 -10-31-2016 Dialysis Clinic, Inc. The Role of Pendrin in Salt Reabsorption in the Distal Tubule in the Setting of Na-Cl Cotransport Inactivation #C-3559 Role:PI $139,737.89 Awarded Level:Private Non-Profit

Grant: #R01DK116789 Investigators:Finkelman, Fred; Shao, Wenhai; Soleimani, Manoocher 04-01-2019 -03-31-2022 National Inst of Diabetes and Digestive and Kidney Disease Axl receptor tyrosine kinase, a potential therapeutic target in glomerulonephritis Role:Collaborator $240,565.00 Awarded Level:Federal

Grant: #W81XWH-20-1-0736 Investigators:McCormack, Francis; Soleimani, Manoocher; Yu, Jane 09-01-2020 -08-31-2023 Department of the Army Medical Research Acquisition Activity Dysregulation of sphingolipid metabolism and actions in tuberous sclerosis complex Role:Collaborator $722,250.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Xu J, Song P, Miller ML, Borgese F, Barone S, Riederer B, Wang Z, Alper SL, Forte JG, Shull GE, Ehrenfield J, Seidler U, Soleimani M (2008. ) Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach .Proc Natl Acad Sci USA, , 105 ,17955-17960

Barone S, Fussell SL, SIngh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, Zuo J, Soleimani M (2009. ) Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension .J Biol Chem, , 287 ,2056-5066

Li HC, Collier JH, Shawki A, Rudra JS, Li EY, Mackenzie B, Soleimani M (2009. ) Sequence- or position-specific mutations in the carboxyl terminal FL motif of the kidney sodium bicarbonate cotransporter (NBCI) disrupt its basolateral targeting and alpha-helical structure .J Membr Biol, , 228 ,111-124

Xu J, Song P, Nakamura S, Miller M, Barone S, Alper SL, Riederer B, Bonhagen J, Arend LJ, Amlal H, Seidler U, Soleimani M (2009. ) Deletion of the chloride transporter Slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion .J Biol Chem, , 282 ,29470-29479

Amlal H, Petrovic S, Xu J, Wang Z, Sun X, Barone S, Soleimani M (2010. ) Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct .Am J Physiol Cell Physiol, , 299 (1 ) ,C33-C41

Xu J, Barone S, Li H, Holiday S, Zahedi K, Soleimani M (2011. ) Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney .Kindey Int, , 80 (9 ) ,926-937

Soleimani S, Barone S, Xu J, Shull GE, Siddiqui F, Zahedi K, Amlal H (2012. ) Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure .Proc Natl Acad Sci U S A, , 109 (33 ) ,13368-13373

Zahedi K, Barone S, Xu J, Steinbergs N, Schuster R, Lentsch AB, Amlal H, Wang J, Caero RA Jr, Soleimani M (2012. ) Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CC14-induced acute liver injury .Am J Physiol: Gastrointestinal Liver Physiol, , 303 (5 ) ,G546-G560

Li HC, Kucher V, Li EY, Conforti L, Zahedi K, Soleimani M (2012. ) The role of aspartic acid residues 405 and 416 of the kidney isotope od sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane .Am J Physiol Cell Physiol, , 302 (12 ) ,C1713-C1730

Anagnostopoulou P, Riederer B, Duerr J, Michel S, Binia A, Agrawal R, Liu X, Kalitzki K, Xiao F, Chen M, Schatterny J, Hartmann D, Thum T, Kabesch M, Soleimani M, Seidler U, Mall M (2012. ) SLC26A9-mediated chloride secretion prevents mucus obstruction in airwar inflammation .J Clin Invest, ,

Amlal H, Xu J, Barone S, Zahedi K, Soleimani M (2013. ) The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion .J Molec Med, , 91 (5 ) ,561-572

Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M (2013. ) Proximal tubule specific knockout of the Na+/H+ exchanger NHE3: effects of bicarbonate absoprtion and ammonium excretion .J Mol Med, ,

Rahmati N, Kunzelmann K, Kongsuphol P, Xu J, barone S, De Zeeuw C, Soleimani M Slc26a11 is a Chloride Channel in the Brain: Expression in Purkinje Cells and Stimulatin of V H+-ATPase .Pflugers Archive, ,

Soleimani M (2013. ) SLC26 Cl-HCO3- exchangers in the kidneys: roles in health and disease .Kidney International, ,

Keywords

genetics of acid base transporters, Epithelial biology and transport, Ischemic reperfusion injury, Fructose-induced hypertension

Contact Information

Academic - Internal Medicine
Medical Sciences Building Room G362
CincinnatiĀ  Ohio, 45267
Phone: 513-558-5471
Fax: 513-558-4309
manoocher.soleimani@uc.edu