Eugene Somoza , MD, PhD

DR. EUGENE SOMOZA is an Emeritus Professor in the Department of Psychiatry & Behavioral Neurosciences at the University of Cincinnati and is also associated with the Cincinnati VA Medical Center. He has been the director of the Cincinnati Addiction Research Center (CinARC) since its founding in 1995, and the principal investigator of the Ohio Valley Node (OVN) of NIDA’s Clinical Trials Network since the OVN became part of the network in 2000. Dr. Somoza started his career in psychiatry as director of the psychiatric emergency room for seven years at the Cincinnati VA Medical Center, after which he directed the Cincinnati VA’s substance abuse program, including the methadone program, for five years. Currently, he devotes his efforts exclusively to research.

With a Ph.D. in physics in addition to an M.D., Dr. Somoza has a strong interest in the development of mathematical models in psychiatry and other areas of medicine. He has twenty six publications on the optimization of diagnostic tests using (a) the statistical techniques of receiver operating characteristic (ROC) curve analysis combined with information theory and (b) artificial neural networks as “diagnostic consultants” for medicine and psychiatry. He also has experience in both basic science research (with nineteen publications in neurochemistry), and clinical research in substance abuse (as the principal investigator or investigator in over thirty clinical trials, with eighteen publications). A current special interest of Dr. Somoza’s is the selection and evaluation of outcome measures to be used in clinical trials on cocaine abuse.

Dr. Somoza serves on the Editorial Board as Research and Statistical Consultant for Journal of Neuropsychiatry and Clinical Neurosciences, and on the Editorial Panel of Journal of Addiction Medicine.

He is a member of the Regional Leadership Committee of the Advisory Board, Great Lakes Addictions Technology Transfer Center (GLATTC).  He is also on the Board of Directors for the Ohio Citizen Advocates.

Medical Degree: Autonomous University of Madrid / Faculty of Medicine

Dr. Somoza has a strong interest in the development of mathematical models in psychiatry and other areas of medicine.

He has twenty six publications on the optimization of diagnostic tests using (a) the statistical techniques of receiver operating characteristic (ROC) curve analysis combined with information theory and (b) artificial neural networks as "diagnostic consultants" for medicine and psychiatry.

He also has experience in both basic science research (with nineteen publications in neurochemistry), and clinical research in substance abuse (as the principal investigator or investigator in over thirty clinical trials, with eighteen publications).

A current special interest of Dr. Somoza's is the selection and evaluation of outcome measures to be used in clinical trials on cocaine abuse.

Grant: #1 U10 DA13732-01 2000 -2005 National Institute for Drug Abuse Clinical Trials Network, Ohio Valley Node. Role:Principal Investigator (and Director) $12M Type:Grant

2007 -2012 National Institute for Drug Abuse (NIDA) (Medication Development for Stimulants (MDS-2)) for conducting Phase-II clinical trials on cocaine and methamphetamine dependence Role:Principal Investigator (and Director) Active

Grant: #R01DA025249 2008 -2011 National Institute for Drug Abuse (NIDA) Multisite Controlled Trial of Cocaine Vaccine (2 of 6) Cincinnati Treatment Site Role:Principal Investigator $913,500 Type:Grant

Catalyst Pharma Vigabatrin for Treatment of Cocaine Dependence: A Phase II Study Type:Contract

Titan Pharma An Open-Label, Multi-Center Study Of Probuphine® In Patients With Opioid Dependence Type:Contract

Reserpine for the treatment of cocaine dependence

Metyrapone for the treatment of cocaine dependence

Tiagabine for the treatment of cocaine dependence

Vigabatrin for the treatment of cocaine dependence

Concerta (OROS methylphenidate) for methamphetamine dependence

Grant: #U10 DA013732 Investigators:Somoza, Eugene 09-01-2005 -09-14-2010 National Institute on Drug Abuse Clinical Trials Network, Ohio Valley Node Role:PI $16,879,999.00 Closed Level:Federal

Grant: #N01DA-9-8095 Investigators:Somoza, Eugene 09-30-1999 -02-28-2010 National Institute on Drug Abuse Clinical Trials Operations Role:PI $7,990,359.92 Closed Level:Federal

Grant: #5-U10-DA-13732-05-A0-S0-E0 Investigators:Somoza, Eugene 09-30-2000 -08-31-2005 National Institute on Drug Abuse Clinical Trials Network, Ohio Valley Node Role:PI $12,037,278.00 Closed Level:Federal

Grant: #K23 DA021512 Investigators:Brigham, Gregory; Somoza, Eugene 09-01-2007 -06-30-2013 National Institute on Drug Abuse Community Reinforcement and Family Training for Treatment Retention/HIV Risk (CDA) Role:Collaborator $864,341.00 Active Level:Federal

Grant: #R01 DA025249 Investigators:Somoza, Eugene; Winhusen, Theresa 09-01-2008 -01-31-2013 National Institute on Drug Abuse Controlled Trial of Cocaine Vaccine (2 of 6) Cincinnati Treatment Center Role:PI $792,842.00 Active Level:Federal

Grant: #SRS6398 Investigators:Somoza, Eugene; Theobald, Jeffrey 07-01-2009 -12-31-2009 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Jeffrey Theobald Role:Collaborator $984.00 Closed Level:Federal

Grant: #SRS 006399 Investigators:Somoza, Eugene; Somoza, Peggy 07-01-2009 -12-31-2009 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Peggy Somoza Role:Collaborator $5,494.00 Closed Level:Federal

Grant: #SRS 006400 Investigators:Dorer, Emily; Somoza, Eugene 07-01-2009 -12-31-2009 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Emily Dorer Role:Collaborator $2,050.00 Closed Level:Federal

Grant: #SRS 006401 Investigators:Lee, Stephanie; Somoza, Eugene 07-01-2009 -12-31-2009 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Stephanie Lee Role:Collaborator $984.00 Closed Level:Federal

Grant: #SRS 006402 Investigators:Lewis, Daniel; Somoza, Eugene 07-01-2009 -12-31-2009 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Daniel Lewis Role:Collaborator $4,113.00 Closed Level:Federal

Grant: #223995 / 1 R01 DA023615-01A2 Investigators:Meganathan, Karthikeyan; Somoza, Eugene; Szaflarski, Magdalena 07-20-2009 -07-31-2012 National Institute on Drug Abuse Immigration Effects on Substance Abuse, Mental Health, and Treatment Gaps Role:Collaborator $155,704.00 Closed Level:Federal

Grant: #HHSN271200788451C Investigators:Somoza, Eugene 04-23-2007 -04-22-2012 National Institute on Drug Abuse Medications Development for Stimulant Dependence (MDS-II) Role:PI $10,000.00 Active Level:Federal

Grant: #PRO-806-019 / 1 RC2 DA028910-01 Rev Investigators:Somoza, Eugene; Winhusen, Theresa 09-30-2009 -08-31-2011 National Institute on Drug Abuse A Six-Month, RCT of Probuphine Safety and Efficacy in the Treatment of Opioid Addiction Role:PI $537,129.00 Active Level:Federal

Grant: #CS#1029 / R01 DA025249-0 Investigators:Somoza, Eugene 05-01-2010 -04-30-2012 National Institute on Drug Abuse Controlled Trial of Cocaine Vaccine (2 of 6) Cincinnati Treatment Center, NIDA Supplemental Funding Role:PI $30,000.00 Active Level:Federal

Grant: #U10 DA013732 Investigators:Burlew, Ann Kathleen Hoard; Fichtenbaum, Carl; Horn, Paul; Lyons, Michael; Somoza, Eugene; Winhusen, Theresa; Wulsin, Lawson 09-15-2010 -08-31-2015 National Institute on Drug Abuse Competing Renewal of Clinical Trials Network, Ohio Valley Node Role:Collaborator $10,370,010.00 Active Level:Federal

Grant: #srs007236 Investigators:Somoza, Eugene 01-17-2011 -01-16-2012 National Institute on Drug Abuse NIDA Clinical Trials Network Research Fellowship for Felipe Vallejo Reyes Role:PI $39,000.00 Active Level:Federal

Grant: #Prime HHSN271201200020C Investigators:Somoza, Eugene; Winhusen, Theresa 08-15-2012 -02-14-2013 National Institute on Drug Abuse Phase I Patient Study for Subcontract under AiCT SBIR Medication Adherence in Higher Risk Populations Role:PI $17,824.00 Active Level:Federal

Grant: #AiCT2 / HHSN271201300036C Investigators:Somoza, Eugene 01-01-2014 -12-31-2014 National Institute on Drug Abuse Clinical Validation and Implementation of a Remote, Real-Time Adherence Monitoring Technology in Opioid-Addicted Patients Receiving Sublingual Buprenorphine Maintenance Therapy: A Multi-Site Randomize Role:PI $336,841.00 Active Level:Federal

Peer Reviewed Publications

Winhusen, Theresa M; Somoza, Eugene C; Brigham, Gregory S; Liu, David S; Green, Carla A; Covey, Lirio S; Croghan, Ivana T; Adler, Lenard A; Weiss, Roger D; Leimberger, Jeffrey D; Lewis, Daniel F; Dorer, Emily M (2010. ) Impact of attention-deficit/hyperactivity disorder (ADHD) treatment on smoking cessation intervention in ADHD smokers: a randomized, double-blind, placebo-controlled trial.The Journal of clinical psychiatry, , More Information

Kampman, Kyle M; Leiderman, Deborah; Holmes, Tyson; LoCastro, Joseph; Bloch, Daniel A; Reid, Malcolm S; Shoptaw, Steve; Montgomery, Margaret A; Winhusen, Theresa M; Somoza, Eugene C; Ciraulo, Domenic A; Elkashef, Ahmed; Vocci, Frank (2005. ) Cocaine Rapid Efficacy Screening Trials (CREST): lessons learned.Addiction (Abingdon, England), , 100 Suppl 1 ,102-10 More Information

Winhusen, Theresa M; Somoza, Eugene C; Harrer, Judy M; Mezinskis, Juris P; Montgomery, Margaret A; Goldsmith, R Jeffrey; Coleman, Florence S; Bloch, Daniel A; Leiderman, Deborah B; Singal, Bonita M; Berger, Paul; Elkashef, Ahmed (2005. ) A placebo-controlled screening trial of tiagabine, sertraline and donepezil as cocaine dependence treatments.Addiction (Abingdon, England), , 100 Suppl 1 ,68-77 More Information

Berger, S Paul; Winhusen, Theresa M; Somoza, Eugene C; Harrer, Judy M; Mezinskis, Juris P; Leiderman, Deborah B; Montgomery, Margaret A; Goldsmith, R Jeffrey; Bloch, Daniel A; Singal, Bonita M; Elkashef, Ahmed (2005. ) A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence.Addiction (Abingdon, England), , 100 Suppl 1 ,58-67 More Information

Somoza, Eugene C; Winhusen, Theresa M; Bridge, T Peter; Rotrosen, John P; Vanderburg, Douglas G; Harrer, Judy M; Mezinskis, Juris P; Montgomery, Margaret A; Ciraulo, Domenic A; Wulsin, Lawson R; Barrett, Jera A (2004. ) An open-label pilot study of methylphenidate in the treatment of cocaine dependent patients with adult attention deficit/hyperactivity disorder. Journal of addictive diseases, , 23 (1 ) ,77-92

Winhusen, Theresa M; Somoza, Eugene C; Singal, Bonita; Kim, Sunme; Horn, Paul S; Rotrosen, John (2003. ) Measuring outcome in cocaine clinical trials: a comparison of sweat patches with urine toxicology and participant self-report. Addiction (Abingdon, England), , 98 (3 ) ,317-24

For more information on the department's Addiction Sciences Division, please go to: Addiction Sciences Division:

CTN Website: http://www.drugabuse.gov/about-nida/organization/cctn/ctn
CTN Information Link: The First Decade: http://ctndisseminationlibrary.org/display/513.htm
NIDA (National Institute on Drug Abuse) Blending Products (created from CTN research findings): http://www.drugabuse.gov/blending-initiative ,

Research - Cincinnati Addiction Research Center (CinARC)
3210 Jefferson Avenue, Suite 6
Cincinnati  Ohio, 45220
Phone: (513) 487-7800
Fax: (513) 487-7819

Academic - Stetson Building
Cincinnati  Ohio, 45219
Phone: 513-558-7700
eugene.somoza@uc.edu