George Stan

George Stan

Associate Professor

Associate Professor

Crosley Tower

1501B

A&S Chemistry - 0172

Professional Summary

George Stan is a physical chemist with research interests in computational biophysical chemistry. He received his undergraduate degree in 1994 at the University of Bucharest, Romania. He obtained his PhD in 1999 at the Pennsylvania State University for work on absorption of gases in carbon nanotubes and wetting of alkali surfaces.

His postdoctoral work in the Institute for Physical Science and Technology at the University of Maryland (2000-2001) and the National Institutes of Health (2002-2006) focused on chaperonin mediated protein folding. His research involves application and development of computational methods within the CHARMM molecular modeling program, as well as bioinformatics methods.

In 2005 he was awarded the Lenfant Biomedical Fellowship at the National Heart, Lung, and Blood Institute.

He joined the faculty at the University of Cincinnati in 2006.

Education

PhD: The Pennsylvania State University University Park, PA, 1999 (Physics)

B.Sc.: University of Bucharest Bucharest, Romania, 1994 (Physics)

Research Support

Grant: #MCB-0952082 Investigators:Stan, George 03-01-2010 -02-29-2016 National Science Foundation CAREER: Computational Modeling of Biological Nanomachines-Protein Unfolding and Translocation by Clp ATPases Role:PI 672,037 Completed Type:Grant Level:National

Grant: #0730167N Investigators:Stan, George 01-01-2007 -12-31-2011 American Heart Association - National Chapter Annealing Action of Chaperonin Proteins: Recognition of Substrate Proteins and Protein Folding Assistance Role:PI Completed Type:Grant

Investigators:Pat Limbach 09-01-2010 -08-31-2013 National Science Foundation ARI: Renovation of Chemistry Facilities at the University of Cincinnati Role:Senior Personnel Completed Type:Grant

Grant: #MCB-0952082-004 Investigators:George Stan 03-27-2012 -02-28-2015 NSF REU Supplemental Funding - CAREER: Computational Modeling of Biological Nanomachines - Protein Unfolding and Translocation by Clp ATPases Role:PI Completed Type:Grant Level:National

Procter&Gamble - UC Simulation Center RA support for 2 graduate students Active Type:Contract

Investigators:Anna Gudmundsdottir National Science Foundation REU program Role:Senior Investigator Active Type:Grant

Grant: #TG-MCB160099 Investigators:George Stan 07-11-2016 -07-11-2017 XSEDE Mechanisms of protein unfolding and translocation by biological nanomachines in the degradation pathway Role:PI 200000 SU Completed Type:Grant Level:National

Grant: #MCB-1516918 Investigators:Stan, George 07-01-2015 -06-30-2020 National Science Foundation Computational Modeling of Protein Degradation by Biological Nanomachines Role:PI $591,529.00 Completed Type:Grant

Grant: #MCB-1740908 Investigators:Dima, Ruxandra; Stan, George 04-15-2017 -03-31-2018 National Science Foundation Conference: From Computational Biophysics to Systems Biology 2017 Role:PI $6,000.00 Completed Type:Grant

Grant: #TG-MCB170020 Investigators:George Stan 04-01-2017 -09-30-2018 XSEDE Mechanisms of protein unfolding and translocation by biological nanomachines in the degradation pathway Role:PI $39164 Completed Type:Grant

Grant: #TG-MCB170020 Investigators:George Stan 01-01-2019 -03-31-2022 XSEDE Mechanisms of protein unfolding and translocation by biological nanomachines in the degradation pathway Role:PI $80,787 Active Type:Grant

Investigators:Stan, George 06-01-2021 -12-17-2021 Kroger Company Kroger- Simulation and Research of Freshness Sensor Project Role:PI 28171.00

Grant: #MCB-2136816 Investigators:Stan, George 12-01-2021 -11-30-2025 National Science Foundation NSF-BSF: Multiscale modeling and single-molecule fluorescence studies of mechanisms of AAA+ disaggregation nanomachines Role:PI 851499.00 Type:Grant

Abbreviated Publications

Peer Reviewed Publications

Javidialesaadi, Abdolreza, & Stan, George (2017). Asymmetric Conformational Transitions in AAA+ Biological Nanomachines Modulate Direction-Dependent Substrate Protein Unfolding Mechanisms. The journal of physical chemistry. B, 121(29), 7108-7121.

Javidialesaadi, Abdolreza, Flournoy, Shanice M, & Stan, George (2019). Role of Diffusion in Unfolding and Translocation of Multidomain Titin I27 Substrates by a Clp ATPase Nanomachine. The journal of physical chemistry. B, 123(12), 2623-2635.

Talley Edwards, Allison, Javidialesaadi, Abdolreza, Weigandt, Katie M, Stan, George, & Eads, Charles D (2019). Structure and Dynamics of Spherical and Rodlike Alkyl Ethoxylate Surfactant Micelles Investigated Using NMR Relaxation and Atomistic Molecular Dynamics Simulations. Langmuir : the ACS journal of surfaces and colloids, 35(43), 13880-13892.

Avestan, Mohammad Sadegh, Javidi, Alex, Ganote, Lillian Priscilla, Brown, Jerrica M, & Stan, George (2020). Kinetic effects in directional proteasomal degradation of the green fluorescent protein. The Journal of chemical physics, 153(10), 105101.

Damre, Mangesh, Dayananda, Ashan, Varikoti, Rohith Anand, Stan, George, & Dima, Ruxandra I (2021). Factors underlying asymmetric pore dynamics of disaggregase and microtubule-severing AAA+ machines. Biophysical journal, 120(16), 3437-3454.

Posgai, Monica T, Tonddast-Navaei, Sam, Jayasinghe, Manori, Ibrahim, George M, Stan, George*, & Herr, Andrew B* (*co-corresponding author) (2018). FcaRI binding at the IgA1 CH2-CH3 interface induces long-range conformational changes that are transmitted to the hinge region. Proceedings of the National Academy of Sciences of the United States of America, 115(38), E8882-E8891.

Sykes, Kiana S, Oliveira, Luiz F L, Stan, George, & White, Ryan J (2019). Electrochemical Studies of Cation Condensation-Induced Collapse of Surface-Bound DNA. Langmuir : the ACS journal of surfaces and colloids, 35(40), 12962-12970.

Fonseka, Hewafonsekage Yasan Y, Javidi, Alex, Oliveira, Luiz F L, Micheletti, Cristian, & Stan, George (2021). Unfolding and Translocation of Knotted Proteins by Clp Biological Nanomachines: Synergistic Contribution of Primary Sequence and Topology Revealed by Molecular Dynamics Simulations. The journal of physical chemistry. B, 125(27), 7335-7350.

Tonddast-Navaei, Sam, & Stan, George (2013). Mechanism of transient binding and release of substrate protein during the allosteric cycle of the p97 nanomachine. Journal of the American Chemical Society, 135(39), 14627-36.

Jayasinghe, Manori, Shrestha, Pooja, Wu, Xiongwu, Tehver, Riina, & Stan, George (2012). Weak intra-ring allosteric communications of the archaeal chaperonin thermosome revealed by normal mode analysis. Biophysical journal, 103(6), 1285-95.

S. M. Doyle, S. Shastry, A. N Kravats, Y.-H. Shih, M. Miot, J. R. Hoskins, G. Stan, and S. Wickner (2015), Interplay between E. coli DnaK, ClpB and GrpE during protein disaggregation, J. Mol. Biol. 427, 312-327.

 H.-Y. Kim, S. M. Gatica, G. Stan, and M. W. Cole (2009) Effects of substrate relaxation on adsorption in pores, J. Low Temp. Phys. 156, 1-8.

Jayasinghe, Manori, Tewmey, Cody, & Stan, George (2010). Versatile substrate protein recognition mechanism of the eukaryotic chaperonin CCT. Proteins, 78(5), 1254-65.

O'Brien, Edward P, Stan, George, Thirumalai, D, & Brooks, Bernard R (2008). Factors governing helix formation in peptides confined to carbon nanotubes. Nano letters, 8(11), 3702-8.

Stan, George, Lorimer, George H, Thirumalai, D, & Brooks, Bernard R (2007). Coupling between allosteric transitions in GroEL and assisted folding of a substrate protein. Proceedings of the National Academy of Sciences of the United States of America, 104(21), 8803-8.

Stan, George, Brooks, Bernard R, Lorimer, George H, & Thirumalai, D (2006). Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state. Proceedings of the National Academy of Sciences of the United States of America, 103(12), 4433-8.

Stan, George, Brooks, Bernard R, & Thirumalai, D (2005). Probing the "annealing" mechanism of GroEL minichaperone using molecular dynamics simulations. Journal of molecular biology, 350(4), 817-29.

Stan, George, Brooks, Bernard R, Lorimer, George H, & Thirumalai, D (2005). Identifying natural substrates for chaperonins using a sequence-based approach. Protein science : a publication of the Protein Society, 14(1), 193-201.

Stan, George, Thirumalai, D, Lorimer, George H, & Brooks, Bernard R (2003). Annealing function of GroEL: structural and bioinformatic analysis. Biophysical chemistry, 100(1-3), 453-67.

Kravats, Andrea, Jayasinghe, Manori, & Stan, George (2011). Unfolding and translocation pathway of substrate protein controlled by structure in repetitive allosteric cycles of the ClpY ATPase. Proceedings of the National Academy of Sciences of the United States of America 108 (1) 2234-2239.

S. M. Gatica, M. M. Calbi, G. Stan, R. A. Trasca, and M. W. Cole (2010) Quasi-one dimensional fluids that exhibit higher dimensional behavior, Int. J. Mod. Phys. B. 24(25-26), 5051-59.

Review

Maurizi, Michael R, & Stan, George (2013). ClpX shifts into high gear to unfold stable proteins. Cell, 155(3), 502-4.More Information

Invited Publication

Andrea N. Kravats, Sam Tonddast-Navaei, and George Stan (2016), Coarse-Grained Simulations of Topology-Dependent Mechanisms of Protein Unfolding and Translocation Mediated by ClpY ATPase Nanomachines, PLOS Comp. Biol. 12(1): e1004675, 1-24 (accepted Nov. 25, 2015; published online Jan. 6, 2016)

G. Stan (2009) Condensation of a Quasi-one Dimensional Gas Within a Single Wall Carbon Nanotube, J. Low Temp. Phys. 157, 374-381.

Kravats, Andrea N, Tonddast-Navaei, Sam, Bucher, Ryan J, & Stan, George (2013). Asymmetric processing of a substrate protein in sequential allosteric cycles of AAA+ nanomachines. The Journal of chemical physics, 139(12), 121921.

Peer Reviewed Conference/Workshop Proceedings

Ruxandra I. Dima and George Stan, "Computational Studies of Mechanical Remodeling of Substrate Proteins by AAA+ Biological Nanomachines", in Modern Applications of Flory’s “Statistical Mechanics of Chain Molecules”, Eds. Alan E. Tonelli and Gary Patterson, ACS Symposium Series Vol. 1356, Ch. 8, pp. 117-141

Under Review

Manases Jora, Daniel Corcoran , Gwenn Parungao , Peter Lobue, Luiz Oliveira, George Stan, Balasubrahmanyam Addepalli, and Patrick Limbach, "Spectral networking of higher-energy collisional dissociation mass spectra facilitates characterization of known and unknown ribonucleoside modifications",  submitted

Presentations

Invited Presentations

George Stan (03-12-2010. ) Computer simulations of protein unfolding and translocation by Clp ATPase nanomachines .Department of Chemistry, Wright State University. Other Institution. .

George Stan (02-26-2010. ) Computer simulations of protein unfolding and translocation by Clp ATPase nanomachines .Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati. UC. . Level:University

George Stan (02-12-2010. ) Protein quality control mechanisms: protein unfolding and translocation by biological nanomachines .Department of Chemistry, Xavier University. Other Institution. .

George Stan (04-02-2009. ) Biological nanomachines at work: chaperonin-mediated protein folding .Department of Chemistry, Central State University. Other Institution. .

George Stan (02-06-2009. ) Biological nanomachines at work: chaperonin-mediated protein folding .Department of Chemistry, Indiana University Purdue University Fort Wayne. Other Institution. .

George Stan (03-18-2011. ) Computer simulations of unfolding and translocation of substrate proteins mediated by allosteric pores .Department of Chemistry, Central State Univ., Other Institution. .

George Stan (04-04-2011. ) Computer simulations of unfolding and translocation of substrate proteins mediated by allosteric pores .Department of Chemistry, Fisk Univ.. Other Institution. .

George Stan (04-04-2011. ) Computational modeling of unfolding and translocation of substrate proteins by AAA biological nanomachines .Department of Chemical Engineering, Vanderbilt Univ.. Other Institution. .

George Stan (10-18-2011. ) Protein quality control mechanisms: protein unfolding and translocation by biological nanomachines' .Department of Chemistry, Indiana State Univ.. Other Institution. .

George Stan (10-19-2011. ) Protein quality control mechanisms: protein unfolding and translocation by biological nanomachines .Department of Chemistry, Rose-Hulman Institute of Technology. Other Institution. .

George Stan (12-18-2012. ) Computational Modeling of Unfolding and Translocation of Substrate Proteins by Clp ATPases .Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati. UC. . Level:University

George Stan (11-01-2012. ) Computer Simulations of Protein Unfolding and Translocation by Clp ATPases in the Protein Degradation Pathway .National Cancer Institute, Lambda Lunch Seminar Series, National Institutes of Health. Other Institution. . Level:National

George Stan (10-05-2012. ) Computational Modeling of Unfolding and Translocation of Substrate Proteins by Ring-Shaped Biological Machines .Department of Physics, Biophysics Seminar, Ohio State University. Other Institution. .

George Stan (07-05-2012. ) Computational Modeling of Unfolding and Translocation of Substrate Proteins by Ring-Shaped Biological Machines .Department of Physics, Technical University Munich. Other Institution. . Level:International

George Stan (02-10-2012. ) Computational Modeling of Unfolding and Translocation of Substrate Proteins by AAA Biological Machines .Department of Chemistry, Central State University. Other Institution. .

George Stan (09-23-2013. ) Computer simulations of protein unfolding and translocation by AAA+ nanomachines .National Heart, Lung, and Blood Institute, National Institutes of Health. Other Institution. . Level:National

George Stan (09-24-2013. ) Computer simulations of protein unfolding and translocation by AAA+ nanomachines .National Cancer Institute, National Institutes of Health. Other Institution. . Level:National

George Stan (05-07-2014. ) Computational studies of protein unfolding and translocation by AAA+ nanomachines .School of Life Sciences, Technical University Munich, Munich, Germany. Other Institution. . Level:University

George Stan (04-28-2014. ) Computational studies of protein unfolding and translocation by AAA+ nanomachines .Department of Chemistry, Technical University Munich, Munich, Germany. Other Institution. . Level:University

George Stan (03-31-2014. ) Computer simulations of protein unfolding and translocation by AAA+ nanomachines .Heidelberg Institute for Theoretical Studies, Heidelberg, Germany. Other Institution. . Level:University

George Stan (12-11-2014. ) Computer simulations of protein unfolding and translocation by AAA+ biological nanomachines .Department of Physics, Indiana University Purdue University Indianapolis, Indianapolis, Indiana. Other Institution. . Level:University

George Stan (10-01-2014. ) Computer simulations of protein unfolding and translocation by AAA+ nanomachines .Department of Chemistry, Rose-Hulman Institute of Technology, Terre Haute, Indiana. Other Institution. . Level:University

George Stan (09-03-2014. ) Computer simulations of protein unfolding and translocation by AAA+ nanomachines .National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Other Institution. . Level:National

George Stan (11-21-2016. ) Multiscale computational modeling of protein unfolding and translocation by AAA+ nanomachines in the degradation pathway .University of Texas, Austin, Austin, TX. Other Institution. . Level:University

George Stan (09-08-2016. ) Coarse-grained and implicit solvent modeling of protein unfolding and translocation in the degradation pathway. National Cancer Institute, National Institutes of Health, Bethesda, MD. Other Institution. . Level:National

George Stan (09-19-2017. ) Multiscale computational modeling of protein unfolding and translocation by AAA+ nanomachines in the degradation pathway .National Cancer Institute, National Institutes of Health, Bethesda, MD. Other Institution. . Level:National

George Stan (09-08-2017. ) Computational modeling of protein unfolding and translocation by AAA+ nanomachines in the degradation pathway .Eastern Kentucky University, Other Institution. . Level:National

George Stan (09-17-2018. ) Unfolding and translocation of multidomain substrate proteins in the degradation pathway .National Cancer Institute, National Institutes of Health, Bethesda, MD. Other Institution. .

George Stan (09-18-2018. ) Unfolding and translocation of multidomain substrate proteins in the degradation pathway .National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. Other Institution. .

George Stan Computational studies of protein disaggregation mechanisms mediated by AAA+ biological nanomachines .National Cancer Institute, NIH, Bethesda, MD.

George Stan (08-26-2019. ) Multiscale modeling of protein unfolding and translocation in the degradation pathway .ACS National Meeting, San Diego, CA.

George Stan (03-05-2020. ) Multiscale computational modeling of protein unfolding and translocation by AAA+ nanomachines in the degradation pathway .Nationwide Children's Hospital, Ohio State Univ., Columbus, OH. Other Institution. .

Poster Presentations

Allison Talley, Andrea Kravats, Sam Tonddast‐Navaei, George Stan Elucidation of binding and unfolding pathways of biopolymers at interfaces via molecular dynamics simulations .2014 Ralph&Helen Oesper Symposium, Cincinnati Section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Rui Jiang, Sam Tonddast‐Navaei, Andrea Kravats, and George Stan Probing Unfolding Mechanisms of GFP by ClpB Using All‐atom Simulation .2014 Ralph&Helen Oesper Symposium, Cincinnati Section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Qi Wang and George Stan Mechanical unfolding and translocation of protein L and protein G through nonallosteric ClpY chaperone .2014 Ralph&Helen Oesper Symposium, Cincinnati Section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Huan Wang and George Stan Unfolding and translocation mechanism of peptides with diverse structures by ClpY ATPase .2014 Ralph&Helen Oesper Symposium, Cincinnati Section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Yu‐Hsuan Shih, Shannon M. Doyle, Shankar Shastry, Andrea Kravats, Marika Miot, Joel R. Hoskings, George Stan and Sue Wickner Computational studies of functional interactions between E. coli. ClpB, DnaK and GrpE during protein disaggregation .2014 Ralph&Helen Oesper Symposium, Cincinnati Section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Abdolreza Javidialesaadi and George Stan Structural Analysis of Constant Domains of IgG Antibodies .2014 Ralph&Helen Oesper Symposium, Cincinnati Section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Nathan Smith, Pooja Shrestha and George Stan Confinement Effects on the Kinetics of a Multi‐Domain Protein Folding in a Nanotube .2014 Ralph&Helen Oesper Symposium, Cincinnati Section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Yu-Hsuan Shih, Shannon M. Doyle, Shankar Shastry, Andrea Kravats, Marika Miot, Joel R. Hoskings, George Stan and Sue Wickner Computational studies of functional interactions of the multi-chaperone ClpB/DnaK/GrpE system for protein disaggregation .Academy of Computational Life Sciences Summer School, Purdue University, West Lafayette, Indiana. . Professional Meeting. . Level:International

Rui Jiang, Sam Tonddast‐Navaei, Andrea Kravats, and George Stan Mechanisms of Protein Disaggregation by Bacterial Proteases .Academy of Computational Life Sciences Summer School, Purdue University, West Lafayette, Indiana. . Professional Meeting. . Level:International

Jessica C McKinley, Andrea Kravats, Huan Wang, George Stan Computer simulations of peptide translocation by ClpY nanomachines .ACS National Meeting March 2014, Dallas, TX. . Professional Meeting. . Level:International

Abdolreza Javidialesaadi and George Stan (11-13-2015. ) Molecular Dynamics Simulation of the Folding Properties of IgG Antibody .2015 Ralph&Helen Oesper Symposium, Cincinnati section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Rui Jiang, Andrea Kravats, and George Stan (11-13-2015. ) Effect of Force Directionality on Unfolding and Translocation Pathways of the Green Fluorescent Protein by the ClpB Biological Nanomachine .2015 Ralph&Helen Oesper Symposium, Cincinnati section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Yu-Hsuan Shih, Shannon M. Doyle, Andrea N. Kravats, Joel R. Hoskins, George Stan and Sue Wickner (11-13-2015. ) Identification of interaction and collaboration between DnaK system and ClpB hexamer during protein disaggregation .2015 Ralph&Helen Oesper Symposium, Cincinnati section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Nathan Smith and George Stan (11-13-2015. ) Normal Mode Analysis of a Protein-Unfolding Biological Nanomachine .2015 Ralph&Helen Oesper Symposium, Cincinnati section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Qi Wang, George Stan (11-13-2015. ) Multi-scale modeling: unfolding and translocation of FtsZ and repA through molecular chaperone .2015 Ralph&Helen Oesper Symposium, Cincinnati section of the American Chemical Society, University of Cincinnati. . UC. . Level:Local

Kyle Vieth, Yu-Hsuan Shih and George Stan (04-24-2015. ) Mechanistic Insights into Disaggregation and Unfolding Functions of Bacterial Clp ATPase Nanomachines .2015 Undergraduate Conference: Research, Scholarship & Creative Work, University of Cincinnati. . UC. . Level:University

Alex Mason, Abdolreza Javidialesaadi and George Stan (04-24-2015. ) Constant Domains of Antigen-Binding Fragment of IgG Antibody: A Bioinformatic Analysis .2015 Undergraduate Conference: Research, Scholarship & Creative Work, University of Cincinnati. . UC. . Level:University

Rui Jiang, Andrea Kravats, and George Stan (05-20-2016. ) ClpB-mediated Unfolding Mechanisms of GFP: Two Different Pathways Breakdown and the Effect of Force Directionality .47th Central Regional Meeting of ACS, Covington, KY. . Level:Regional

Qi Wang, George Stan (05-20-2016. ) Normal mode analysis of conformational changes in the ClpP peptidase .47th Central Regional Meeting of ACS, Covington, KY. . Level:Regional

Y. Shih , G. Stan (05-20-2016. ) Molecular Dynamics Simulations of Protein Unfolding and Translocation by the ClpY ATPase in the Protein Degradation Pathway .47th Central Regional Meeting of ACS, Covington, KY. . Level:Regional

Allison Talley, Abdolreza Javidialesaadi, Charles Eads and George Stan Small Molecule Effects on Surfactant Microstructure and Dynamics: A Case Where MD and NMR Drive Understanding in How Partitioning Influences Physical Properties .From Computational Biophysics to Systems Biology (CBSB2017), Cincinnati,OH. . UC. . Level:International

Yu-Hsuan Shih and George Stan Probing the Mechanism of Protein Unfolding and Translocation by the ClpY ATPase during Protein Degradation .From Computational Biophysics to Systems Biology (CBSB2017), Cincinnati,OH. . UC. . Level:International

Abdolreza Javidialesaadi and George Stan Computer Simulations of Protein Remodeling by Ring-Shaped Biological Nanomachines .From Computational Biophysics to Systems Biology (CBSB2017), Cincinnati,OH. . UC. . Level:International

Qi Wang, Riina Tehver and George Stan Normal Mode Analysis of Conformational Changes in the ClpP Peptidase .From Computational Biophysics to Systems Biology (CBSB2017), Cincinnati,OH. . UC. . Level:International

Yasan Fonseka, Abdolreza Javidialesaadi and George Stan Computer Simulations of the Dynamics of IgG Antibody Binding-Region .From Computational Biophysics to Systems Biology (CBSB2017), Cincinnati,OH. . Conference. . Level:International

Rui Jiang and George Stan Unfolding and Translocation Mechanism of Green Fluorescent Protein Mediated by the ClpB Biological Nanomachine .From Computational Biophysics to Systems Biology (CBSB2017), Cincinnati,OH. . Professional Meeting. . Level:International

Mohammad Sadegh Avestan, Abdolreza Javidialesaadi and George Stan Coarse-grained Simulations of Green Fluorescent Protein Unfolding Mediated by 26S Proteasome .From Computational Biophysics to Systems Biology (CBSB2017), Cincinnati,OH. . Professional Meeting. . Level:International

Abdolreza Javidialesaadi and George Stan GPU-accelerated molecular dynamics simulations of protein remodeling mediated by AAA+ biological nanomachines .254th ACS National Meeting, Washington, DC. . Professional Meeting. . Level:International

Mohammad Sadegh Avestan, George Stan and Abdolreza Javidialesadi (11-17-2017. ) Computer simulation of mechanical unfolding of tandem Green Fluorescent Protei n in bulk or mediated by the 26S proteasome .2017 Ralph&Helen Oesper Symposium, University of CIncinnati. . Professional Meeting. . Level:University

Allison Talley, Abdolreza Javidialesaad i,George Stan, Charlie Eads (11-17-2017. ) Surfactant Microstructure and Dynamics: A Case Where MD and NMR Drive Understanding .2017 Ralph&Helen Oesper Symposium, University of CIncinnati. . Professional Meeting. .

Yasan Fonseka, Abdolreza javidialesaadi, Andrew Herr, George Stan (11-17-2017. ) Effect of hinge disulfide bonds on antibody Binding Region of Immunoglobulin -G .2017 Ralph&Helen Oesper Symposium, University of CIncinnati. . Professional Meeting. .

Yasan Fonseka, Abdolreza Javidialesaadi and George Stan (11-09-2018. ) Computer simulations of unfolding and translocation mechanisms of the HaloTag protein mediated by the ClpY ATPase nanomachine .2018 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Qi Wang and George Stan (11-09-2018. ) Computational study of conformational transition of the axial pore of bacterial ClpP peptidase .2018 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Mohammad Sadegh Avestan, Abdolreza Javidialesaadi and George Stan (11-09-2018. ) Inter-domain Stabilization of Green Fluorescent Protein Dimers During Proteasomal Degradation Initiated From Internal Sites .2018 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Mohammad Avestan, Abdolreza Javidialesaadi, George Stan (09-27-2019. ) Computer simulation studies of proteasome-mediated degradation of green fluorescent protein substrates initiated at internal sites .2018 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Luiz Oliveira, Abdolreza Javidialesaadi, George Stan (09-27-2019. ) Probing degradation mechanisms of knotted proteins mediated by Clp biological nanomachines using molecular dynamics simulations .2019 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Ashan Dayananda, George Stan (09-27-2019. ) Probing Translocation Mechanism of a Modeled Substrate Mediated by ClpB Biological Nanomachines Using Targeted Molecular Dynamics Simulations. 2019 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Qi Wang, George Stan (09-27-2019. ) Transition Pathway Between Axial Transition Closed and Open States of Bacterial ClpP Peptidase .2019 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Lillian Priscilla Ganote, Mohammad Sadegh Avestan and George Stan (04-22-2019. ) Computational Study of the Inter-Domain Stabilization of Tandem Green Fluorescent Substrate Proteins During Proteasomal Degradation Initiated From Internal Sites .2019 Undergraduate Scholarly Showcase , University of Cincinnati. .

Yasan Fonseka, Alex Javidi, Luiz F. L. Oliveira, Cristian Micheletti, George Stan (02-2021. ) Effect of non–native interactions on Clp ATPase–Mediated Degradation of Knotted Proteins Revealed using Molecular Dynamics .Biophysical Society 65th Virtual Annual Meeting 2021, Virtual meeting. . Level:International

Ashan Dayananda, Ruxandra I. Dima, George Stan (03-16-2021. ) Computational Studies of Asymmetric Conformational Dynamics of AAA+ Machines Involved in Protein Disaggregation .American Physical Society March Meeting 2021, Virtual meeting. . Level:International

George Stan, Yasan Fonseka, Alex Javidi, Luiz Oliveira, Cristian Micheletti (09-10-2021. ) Protein degradation mechanisms of Clp ATPases: synergistic role of primary sequence and topology of substrate proteins – molecular dynamics studies .CECAM workshop on "Nanopore Translocation and Nanochannel Confined Biopolymers", Hybrid meeting at SISSA, Italy. . Level:International

Zhe Zhao and George Stan Coarse-grained Simulation Studies of the Dynamic Stability of ClpB Disaggregation Nanomachine .2021 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Ashan Dayananda, Ruxandra Dima, and George Stan Computational Studies of Asymmetric Conformational Dynamics of ClpB Disaggregase Nanomachine .2021 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Zhaocheng Zhang, Ashan Dayananda, and George Stan (10-22-2021. ) Coarse-Grained Structure-Based Model of functional dynamics of the ClpB AAA+ Nanomachine .2021 Ralph&Helen Oesper Symposium, University of Cincinnati. .

Colloquium

G. Stan (03-01-2018). Computational modeling of protein unfolding and translocation by AAA+ nanomachines in the degradation pathway .Transylvania University.

Paper Presentations

Shannon M. Doyle, Andrea N. Kravats, Joel R. Hoskins, Yu-Hsuan Shih, George Stan and Sue Wickner (06-10-2015. ) Interaction and collaboration between DnaK and ClpB during protein disaggregation .SUNY at Albany. Professional Meeting. Level:International

Yu-Hsuan Shih, Shannon M. Doyle, Andrea N. Kravats, Joel R. Hoskins, George Stan and Sue Wickner (05-17-2015. ) Computational studies of collaboration between E. coli ClpB and cofactors DnaK/GrpE during protein disaggregation .Norman, OK. Professional Meeting. Level:International

Abdolreza Javidialesaadi and George Stan (05-19-2016. ) Coarse - grained simulations of mechanical threading of Immunoglobulin domains through non - allosteric ClpY ATPase pore .Covington, KY. Professional Meeting. Level:Regional

M. Jayasinghe , Q. Wang, A. Schirmer, G. Stan, S. Paula (05-19-2016. ) Investigation of inhibitory potency of BHQ derivatives as SERCA inhibitors to use as potential drugs as well as tools to study the SERCA function: Binding free energy computation using FEP/ MD . .Covington, KY. Professional Meeting. Level:Regional

Abdolreza Javidialesaadi and George Stan (10-28-2016. ) Atomistic simulations of unfolding and translocation of the Immunoglobulin domain I27 in repetitive cycles of the ClpY Biological Nanomachines .University of Cincinnati. Professional Meeting. Level:Local

Yu-Hsuan Shih, Shannon M. Doyle, Andrea N. Kravats, Joel R. Hoskins , Sue Wickner and George Stan (10-28-2016. ) Computational Studies of Dyn amic Collaboration between ClpB and co-factor DnaK during Protein Disaggregation .University of Cincinnati. UC. Level:Local

Rui Jiang and George Stan Effect of Force Directionality on ClpB-mediated Unfolding Mechanisms of GFP and superfolder GFP .University of Cincinnati. UC. Level:Local

Allison Talley, Reza Javidi, George Stan (10-28-2016. ) Small Molecule Effects on Surfactant Microstructure and Dynamics: A Case Where MD and NMR Can Drive Understanding in How Partitioning Influences Physical Properties .University of Cincinnati. UC. Level:Local

Qi Wang, Riina Tehver and George Stan (10-28-2016. ) Normal Mode Analysis of Conformational Changes in the ClpP Peptidase .University of Cincinnati. UC. Level:Local

Abdolreza Javidialesaadi and George Stan Unfolding Efficacy of the Immunoglobulin Domain I27 Controlled by Force Directionality in Protein Remodeling by Clp ATPase Chaperones .New Orleans, LA. Professional Meeting. Level:International

Abdolreza Javidialesaadi and George Stan Direction-dependent protein remodeling by AAA+ biological nanomachines .Washington, DC. Professional Meeting. Level:International

Symposium

George Stan (10-01-2010. ) Computer simulations of protein unfolding and translocation mediated by allosteric pores .Seoul, South Korea. Professional Meeting. Level:International

George Stan (08-23-2010. ) Unfolding and translocation of substrate proteins mediated by allosteric pores .Berder Island, France. Professional Meeting. Level:International

George Stan (12-06-2011. ) Development of coarse-grained models of unfolding and translocation of substrate proteins by AAA+ nanomachines .Xcaret, Mexico. Professional Meeting. Level:International

George Stan (12-15-2015. ) Role of confinement in chaperone-mediated protein remodeling .Punta Cana, Dominican Republic. Professional Meeting. Level:International

George Stan (01-11-2012. ) Proteins in Action .Ventura, CA. Professional Meeting. Level:International

George Stan (07-26-2016. ) Coarse-grained and implicit solvent modeling of protein unfolding and translocation in the degradation pathway .Telluride, CO. Professional Meeting. Level:International

George Stan (03-26-2012. ) Computational Modeling of Unfolding and Translocation of Substrate Proteins by AAA Biological Machines .University of Kentucky. Professional Meeting. Level:National

George Stan (12-05-2017. ) Remodeling of protein structure on the surface of a AAA+ nanomachine .Montego Bay, Jamaica. Professional Meeting. Level:International

George Stan (06-28-2012. ) Computational Modeling of Unfolding and Translocation of Substrate Proteins by Ring-Shaped Biological Machines .Telluride, CO. Workshop. Level:International

George Stan (07-23-2018. ) Unfolding and translocation of multidomain substrate proteins in the degradation pathway .Telluride, CO. Professional Meeting.

George Stan (07-26-2012. ) Coarse-grained models of substrate protein unfolding and translocation by AAA+ biological nanomachines .Telluride, CO. Workshop. Level:International

George Stan (06-2021. ) Direction-dependent mechanisms of protein remodeling mediated by AAA+ nanomachines .Telluride virtual conference. Conference. Level:International

George Stan (10-23-2012. ) Atomistic simulations of peptide unfolding and translocation by AAA+ biological nanomachines .Chicago, IL. Professional Meeting. Level:International

George Stan (12-05-2012. ) Computer Simulations of Protein Unfolding and Translocation by Ring Nanomachines in the Degradation Pathway .Xcaret, Mexico. Professional Meeting. Level:International

George Stan Computer simulations of protein unfolding and translocation by AAA+ chaperones .Pultusk, Poland. Professional Meeting. Level:International

George Stan Computational studies of protein unfolding and translocation through repetitive pulling in allosteric cycles of AAA+ motors .Telluride, Colorado. Workshop. Level:International

George Stan Topology-dependent mechanisms of protein unfolding and translocation by AAA+ nanomachines .Xcaret, Mexico. Professional Meeting. Level:International

George Stan (02-03-2014. ) Computer simulations of protein unfolding and translocation by AAA+ nanomachines .Linz, Austria. Professional Meeting. Level:International

George Stan (06-24-2014. ) Mechanisms of substrate protein unfolding and translocation in repetitive cycles of AAA+ nanomachines .Telluride, Colorado. Professional Meeting. Level:International

George Stan (06-09-2014. ) Computational Studies of Protein Unfolding and Translocation in Allosteric Cycles of AAA+ Nanomachines .Boston, Massachusetts. Professional Meeting. Level:International

George Stan (08-06-2014. ) Protein unfolding and translocation by repetitive forces in the degradation pathway .Telluride, Colorado. Professional Meeting. Level:International

George Stan (08-15-2014. ) Development of computational models of protein unfolding and translocation mechanisms by bacterial proteases .Purdue University, West Lafayette, Indiana. Professional Meeting. Level:International

George Stan (03-19-2014. ) Computational studies of actin folding within cylindrical nanopores .Professional Meeting. Level:International

Event Organized

Zimmer scholar week

Zimmer scholar week Other 05-12-2008 05-16-2008 Dept. of Chemistry, University of Cincinnati

2014 Great Lakes Bioinformatics Conference Program committee

2014 Great Lakes Bioinformatics Conference Program committee Prof. Meeting 05-16-2014 05-18-2014 Cincinnati Children’s Hospital, University of Cincinnati Level:International

47th Annual Central Regional Meeting of the ACS - session on Molecular Modeling of Energy Storage Devices & Biomolecular Complexes

47th Annual Central Regional Meeting of the ACS - session on Molecular Modeling of Energy Storage Devices & Biomolecular Complexes Conference 05-18-2016 05-21-2016 Covington, KY Level:Regional

From Computational Biophysics to Systems Biology (CBSB2017)

From Computational Biophysics to Systems Biology (CBSB2017) Conference 05-18-2017 05-20-2017 University of Cincinnati Level:International

2018 Ralph&Helen Oesper Symposium

2018 Ralph&Helen Oesper Symposium Symposium 11-09-2018 11-09-2018 University of Cincinnati

Honors and Awards

04-2016 Lowenstein award Status:Recipient Level:Department

Service

(Graduate Admissions ) Committee Chair Type:Departmental Service Level:Department

(Graduate curriculum committee ) Committee Member Type:Departmental Service Level:Department

(Undergraduate curriculum committee ) Committee Member Type:Departmental Service Level:Department

(Ad-hoc committee on core courses ) Committee Member Type:Departmental Service Level:Department

National Science Foundation Committee Member Type:Grant Panel Level:National

(Advisor to Head ) Type:Departmental Service

(Executive Committee ) Type:Departmental Service

(Graduate Admissions Committee ) Committee Chair Type:Departmental Service

(Advisor to Head ) Type:Departmental Service

(Coeus software replacement ) Member Type:University/College Service

(Graduate curriculum committee ) Committee Member Type:Departmental Service

(Biophysics search committee ) Reviewer Type:University/College Service

Ohio Supercomputer Center Reviewer Type:Grant Panel

(Advisor to Head ) Type:Departmental Service

(Graduate Admissions Committee ) Committee Chair

BioNexus KC Patton Trust Research Grant Program Reviewer Type:Grant Panel

(Advisor to Head ) Type:Departmental Service

(Graduate Curriculum Committee ) Committee Member Type:Departmental Service

(Inquiry Committee ) Committee Member Type:University/College Service

(Advisor to Head ) Type:Departmental Service Level:Department

(Graduate Curriculum Committee ) Committee Member Type:Departmental Service Level:Department

(Visiting Assistant Professor search committee ) Committee Chair Type:Departmental Service Level:Department

(Graduate Program Director ) Program Director Type:Departmental Service Level:Department

American Physical Society (Focus Session on "Molecular Machines" at American Physical Society March Meeting 2022 Conference Chicago, IL International ) Co-Chair Type:Service to Professional Associations Level:International

Post Graduate Training and Education

01-01-2000-12-31-2001 Postdoctoral Research Associate, University of Maryland, , College Park, MD

01-01-2002-08-31-2006 IRTA Fellow, National Institutes of Health, , Bethesda, MD

Keywords

biological, theory, computational chemistry, computational molecular biology

Professional Affiliation

American Physical Society

American Chemical Society

Biophysical Society

Courses Taught

15-CHEM-383 PHYSICAL CHEM III Level:Undergraduate

15-CHEM-381 PHYSICAL CHEM I Level:Undergraduate

15-CHEM-802 ADV COMP CHEM II Level:Graduate

15-CHEM-721 ADV PHYS CHEM I Level:Graduate

15-CHEM-383 PHYSICAL CHEM III Level:Undergraduate

15-CHEM-721 ADV PHYS CHEM I Level:Graduate

15-CHEM-802 ADV COMP CHEM II Level:Graduate

15-CHEM-721 ADV PHYS CHEM I Level:Graduate

15-CHEM-383 PHYSICAL CHEM III Level:Undergraduate

Thermodynamics and Molecular Interactions Level:Graduate

Quantum Mechanics and Spectroscopy Level:Graduate

Computational Chemistry II Level:Graduate

Physical Chemistry II Level:Undergraduate

Quantum Mechanics and Spectroscopy Level:Graduate

Advanced Computational Chemistry II Level:Graduate

-CHEM-3010 SURVEY PHYS CHEM Level:Undergraduate

PHYS CHEM II Level:Undergraduate

Advanced Computational Chemistry II Level:Graduate

PHYS CHEM II Level:Undergraduate

Physical Chemistry II Level:Undergraduate

Topics in Physical Chemistry Level:Graduate

-CHEM-3010 SURVEY PHYS CHEM Level:Undergraduate

Big Data Science in Chemistry Level:Both

Physical Chemistry II Level:Undergraduate

-CHEM-3010 SURVEY PHYS CHEM Level:Undergraduate

Physical Chemistry II Level:Undergraduate