Daniel Starczynowski, Ph.D.

Daniel Starczynowski, Ph.D. , PhD


Childrens Hospital Bldg R

COM Pediatrics Experimental Hematology - 0054

Research and Practice Interests

The Starczynowski Lab has an interest in understanding the molecular and cellular basis of hematologic malignancies, with an emphasis on Myelodysplastic Syndromes and Acute Myeloid Leukemia. 


Peer Reviewed Publications

Fang, Jing; Barker, Brenden; Bolanos, Lyndsey; Liu, Xiaona; Jerez, Andres; Makishima, Hideki; Christie, Susanne; Chen, Xiaoting; Rao, Dinesh S; Grimes, H Leighton; Komurov, Kakajan; Weirauch, Matthew T; Cancelas, Jose A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T (2014. ) Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-kappaB gene network.Cell reports, , 8 (5 ) ,1328-38 More Information

Starczynowski, Daniel T (2014. ) Errant innate immune signaling in del(5q) MDS.Blood, , 124 (5 ) ,669-71 More Information

Beverly, Levil J; Starczynowski, Daniel T (2014. ) IRAK1: oncotarget in MDS and AML. Oncotarget, , 5 (7 ) ,1699-700

Zhao, Jimmy L; Starczynowski, Daniel T (2014. ) Role of microRNA-146a in normal and malignant hematopoietic stem cell function.Frontiers in genetics, , 5 ,219 More Information

Rhyasen, Garrett W; Bolanos, Lyndsey; Starczynowski, Daniel T (2013. ) Differential IRAK signaling in hematologic malignancies.Experimental hematology, , 41 (12 ) ,1005-7 More Information

Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi (2013. ) Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis.Haematologica, , 98 (9 ) ,1353-8 More Information

Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T (2013. ) Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome.Cancer cell, , 24 (1 ) ,90-104 More Information

Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T (2012. ) Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1.Blood, , 120 (4 ) ,858-67 More Information

Vercauteren, Suzanne M; Starczynowski, Daniel T; Sung, Sandy; McNeil, Kelly; Salski, Chris; Jensen, Clara-Lynn; Bruyere, Helene; Lam, Wan L; Karsan, Aly (2012. ) T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. British journal of haematology, , 156 (3 ) ,409-12

Fang, Jing; Varney, Melinda; Starczynowski, Daniel T (2012. ) Implication of microRNAs in the pathogenesis of MDS. Current pharmaceutical design, , 18 (22 ) ,3170-9

Starczynowski, Daniel T; Lockwood, William W; Deléhouzée, Sophie; Chari, Raj; Wegrzyn, Joanna; Fuller, Megan; Tsao, Ming-Sound; Lam, Stephen; Gazdar, Adi F; Lam, Wan L; Karsan, Aly (2011. ) TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer.The Journal of clinical investigation, , 121 (10 ) ,4095-105 More Information

Kuchenbauer, Florian; Mah, Sarah M; Heuser, Michael; McPherson, Andrew; Rüschmann, Jens; Rouhi, Arefeh; Berg, Tobias; Bullinger, Lars; Argiropoulos, Bob; Morin, Ryan D; Lai, David; Starczynowski, Daniel T; Karsan, Aly; Eaves, Connie J; Watahiki, Akira; Wang, Yuzhuo; Aparicio, Samuel A; Ganser, Arnold; Krauter, Jürgen; Döhner, Hartmut; Döhner, Konstanze; Marra, Marco A; Camargo, Fernando D; Palmqvist, Lars; Buske, Christian; Humphries, R Keith (2011. ) Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells.Blood, , 118 (12 ) ,3350-8 More Information

Starczynowski, Daniel T; Vercauteren, Suzanne; Sung, Sandy; Brooks-Wilson, Angela; Lam, Wan L; Karsan, Aly (2011. ) Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes.Leukemia research, , 35 (4 ) ,444-7 More Information

Starczynowski, Daniel T; Kuchenbauer, Florian; Wegrzyn, Joanna; Rouhi, Arefeh; Petriv, Oleh; Hansen, Carl L; Humphries, R Keith; Karsan, Aly (2011. ) MicroRNA-146a disrupts hematopoietic differentiation and survival.Experimental hematology, , 39 (2 ) ,167-178.e4 More Information

Starczynowski, Daniel T; Morin, Ryan; McPherson, Andrew; Lam, Jeff; Chari, Raj; Wegrzyn, Joanna; Kuchenbauer, Florian; Hirst, Martin; Tohyama, Kaoru; Humphries, R Keith; Lam, Wan L; Marra, Marco; Karsan, Aly (2011. ) Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations.Blood, , 117 (2 ) ,595-607 More Information

Vercauteren, Suzanne M; Sung, Sandy; Starczynowski, Daniel T; Lam, Wan L; Bruyere, Helene; Horsman, Douglas E; Tsang, Peter; Leitch, Heather; Karsan, Aly (2010. ) Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities.American journal of clinical pathology, , 134 (1 ) ,119-26 More Information

Starczynowski, Daniel T; Karsan, Aly (2010. ) Innate immune signaling in the myelodysplastic syndromes.Hematology/oncology clinics of North America, , 24 (2 ) ,343-59 More Information

Starczynowski, Daniel T; Karsan, Aly (2010. ) Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q. Cell cycle (Georgetown, Tex.), , 9 (5 ) ,855-6

Starczynowski, Daniel T; Kuchenbauer, Florian; Argiropoulos, Bob; Sung, Sandy; Morin, Ryan; Muranyi, Andrew; Hirst, Martin; Hogge, Donna; Marra, Marco; Wells, Richard A; Buckstein, Rena; Lam, Wan; Humphries, R Keith; Karsan, Aly (2010. ) Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.Nature medicine, , 16 (1 ) ,49-58 More Information

Starczynowski, Daniel T; Vercauteren, Suzanne; Telenius, Adele; Sung, Sandy; Tohyama, Kaoru; Brooks-Wilson, Angela; Spinelli, John J; Eaves, Connie J; Eaves, Allen C; Horsman, Douglas E; Lam, Wan L; Karsan, Aly (2008. ) High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.Blood, , 112 (8 ) ,3412-24 More Information

Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D (2005. ) Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability.Oncogene, , 24 (49 ) ,7355-68 More Information

Kalaitzidis, Demetrios; Ok, John; Sulak, Lawrence; Starczynowski, Daniel T; Gilmore, Thomas D (2004. ) Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells.Oncogene, , 23 (45 ) ,7580-7 More Information

Gilmore, Thomas D; Starczynowski, Daniel T; Kalaitzidis, Demetrios (2004. ) RELevant gene amplification in B-cell lymphomas?.Blood, , 103 (8 ) ,3243-4; author reply More Information

Gilmore, Thomas D; Kalaitzidis, Demetrios; Liang, Mei-Chih; Starczynowski, Daniel T (2004. ) The c-Rel transcription factor and B-cell proliferation: a deal with the devil.Oncogene, , 23 (13 ) ,2275-86 More Information

Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D (2003. ) Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells.Oncogene, , 22 (44 ) ,6928-36 More Information

Leonida, Mihaela D; Starczynowski, Daniel T; Waldman, Riva; Aurian-Blajeni, Benedict (2003. ) Polymeric FAD used as enzyme-friendly mediator in lactate detection.Analytical and bioanalytical chemistry, , 376 (6 ) ,832-7 More Information

Gilmore, Thomas; Gapuzan, Maria-Emily; Kalaitzidis, Demetrios; Starczynowski, Daniel (2002. ) Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer letters, , 181 (1 ) ,1-9

Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A (2014. ) p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-kappaB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche.Cell reports, , 9 (6 ) ,2084-97 More Information

Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT (2016. ) Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome .Leukemia, , 50 ,85

Fang J, Liu X, Bolanos L, Barker B, Rigolino C, Cortelezzi A, Oliva EN, Cuzzola M, Grimes HL, Fontanillo C, Komurov K, MacBeth K, Starczynowski DT (2016. ) A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes .Nature Medicine, , 22 (7 ) ,727

Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI (2015. ) IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival .Oncotarget, , 6 (41 ) ,43395

Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT (2015. ) Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling .Journal of Experimental Medicine, , 212 (11 ) ,1967

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T (2017. ) Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.Nature Immunology, , 18 (2 ) ,236-245 More Information

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T (2018. ) TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.Cell reports, , 22 (5 ) ,1250-1262 More Information

Culver-Cochran, Ashley E; Starczynowski, Daniel T (2018. ) Chronic innate immune signaling results in ubiquitination of splicing machinery.Cell cycle (Georgetown, Tex.), , 1-4 More Information

Kong, Fansheng; Liu, Zhiwei; Jain, Viral G; Shima, Kenjiro; Suzuki, Takuji; Muglia, Louis J; Starczynowski, Daniel T; Pasare, Chandrashekhar; Bhattacharyya, Sandip (2017. ) Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages.Journal of immunology (Baltimore, Md. : 1950), , 199 (10 ) ,3654-3667 More Information

Barreyro, Laura; Chlon, Timothy M; Starczynowski, Daniel T (2018. ) Chronic immune response dysregulation in MDS pathogenesis.Blood, , 132 (15 ) ,1553-1560 More Information

Wei, Yue; Zheng, Hong; Bao, Naran; Jiang, Shan; Bueso-Ramos, Carlos E; Khoury, Joseph; Class, Caleb; Lu, Yue; Lin, Kevin; Yang, Hui; Ganan-Gomez, Irene; Starczynowski, Daniel T; Do, Kim-Anh; Colla, Simona; Garcia-Manero, Guillermo (2018. ) KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice.Blood advances, , 2 (19 ) ,2491-2504 More Information

Rawat, Radhika; Starczynowski, Daniel T; Ntziachristos, Panagiotis (2019. ) Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease.Current opinion in cell biology, , 58 ,85-94 More Information

Smith, Molly A; Choudhary, Gaurav S; Pellagatti, Andrea; Choi, Kwangmin; Bolanos, Lyndsey C; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Von Ahrens, Dagny; Pradhan, Kith; Steeples, Violetta; Kim, Sanghyun; Steidl, Ulrich; Walter, Matthew; Fraser, Iain D C; Kulkarni, Aishwarya; Salomonis, Nathan; Komurov, Kakajan; Boultwood, Jacqueline; Verma, Amit; Starczynowski, Daniel T (2019. ) U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.Nature cell biology, , More Information

Varney, M E; Choi, K; Bolanos, L; Christie, S; Fang, J; Grimes, H L; Maciejewski, J P; Inoue, J-I; Starczynowski, D T (2017. ) Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.Leukemia, , 31 (2 ) ,491-495 More Information

Gañán-Gómez, I; Wei, Y; Starczynowski, D T; Colla, S; Yang, H; Cabrero-Calvo, M; Bohannan, Z S; Verma, A; Steidl, U; Garcia-Manero, G (2015. ) Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes.Leukemia, , 29 (7 ) ,1458-69 More Information

Rhyasen, G W; Starczynowski, D T (2015. ) IRAK signalling in cancer.British journal of cancer, , 112 (2 ) ,232-7 More Information

Wilson, I M; Vucic, E A; Enfield, K S S; Thu, K L; Zhang, Y A; Chari, R; Lockwood, W W; Radulovich, N; Starczynowski, D T; Banáth, J P; Zhang, M; Pusic, A; Fuller, M; Lonergan, K M; Rowbotham, D; Yee, J; English, J C; Buys, T P H; Selamat, S A; Laird-Offringa, I A; Liu, P; Anderson, M; You, M; Tsao, M S; Brown, C J; Bennewith, K L; MacAulay, C E; Karsan, A; Gazdar, A F; Lam, S; Lam, W L (2014. ) EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk.Oncogene, , 33 (36 ) ,4464-73 More Information

Rhyasen, G W; Wunderlich, M; Tohyama, K; Garcia-Manero, G; Mulloy, J C; Starczynowski, D T (2014. ) An MDS xenograft model utilizing a patient-derived cell line.Leukemia, , 28 (5 ) ,1142-5 More Information

Rhyasen, G W; Starczynowski, D T (2012. ) Deregulation of microRNAs in myelodysplastic syndrome.Leukemia, , 26 (1 ) ,13-22 More Information

Sekeres, Mikkael A; Gore, Steven D; Stablein, Donald M; DiFronzo, Nancy; Abel, Gregory A; DeZern, Amy E; Troy, Jesse D; Rollison, Dana E; Thomas, John W; Waclawiw, Myron A; Liu, Jane Jijun; Al Baghdadi, Tareq; Walter, Matthew J; Bejar, Rafael; Gorak, Edward J; Starczynowski, Daniel T; Foran, James M; Cerhan, James R; Moscinski, Lynn C; Komrokji, Rami S; Deeg, H Joachim; Epling-Burnette, Pearlie K (2019. ) The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes.Leukemia & lymphoma, , 1-11 More Information

Melgar, Katelyn; Walker, Morgan M; Jones, LaQuita M; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Jiang, Jiang-Kang; Wilson, Kelli M; Zhang, Xiaohu; Sutter, Patrick; Wang, Amy; Xu, Xin; Choi, Kwangmin; Tawa, Gregory; Lorimer, Donald; Abendroth, Jan; O'Brien, Eric; Hoyt, Scott B; Berman, Ellin; Famulare, Christopher A; Mulloy, James C; Levine, Ross L; Perentesis, John P; Thomas, Craig J; Starczynowski, Daniel T (2019. ) Overcoming adaptive therapy resistance in AML by targeting immune response pathways.Science translational medicine, , 11 (508 ) , More Information

Jones, LaQuita M; Melgar, Katelyn; Bolanos, Lyndsey; Hueneman, Kathleen; Walker, Morgan M; Jiang, Jian-Kang; Wilson, Kelli M; Zhang, Xiaohu; Shen, Jian; Jiang, Fan; Sutter, Patrick; Wang, Amy; Xu, Xin; Tawa, Gregory J; Hoyt, Scott B; Wunderlich, Mark; O'Brien, Eric; Perentesis, John P; Starczynowski, Daniel T; Thomas, Craig J (2020. ) Targeting AML-associated FLT3 mutations with a type I kinase inhibitor.The Journal of clinical investigation, , More Information

Niederkorn, Madeline; Hueneman, Kathleen; Choi, Kwangmin; Varney, Melinda E; Romano, Laurel; Pujato, Mario A; Greis, Kenneth D; Inoue, Jun-Ichiro; Meetei, Ruhikanta; Starczynowski, Daniel T (2020. ) TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.Cell reports, , 30 (8 ) ,2776-2790.e6 More Information

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T (2020. ) Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.Nature immunology, , 21 (5 ) ,535-545 More Information