Daniel Starczynowski, PHD

The Starczynowski Lab has an interest in understanding the molecular and cellular basis of hematologic malignancies, with an emphasis on Myelodysplastic Syndromes and Acute Myeloid Leukemia. 
 

Peer Reviewed Publications

Fang, Jing; Barker, Brenden; Bolanos, Lyndsey; Liu, Xiaona; Jerez, Andres; Makishima, Hideki; Christie, Susanne; Chen, Xiaoting; Rao, Dinesh S; Grimes, H Leighton; Komurov, Kakajan; Weirauch, Matthew T; Cancelas, Jose A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T  (2014). Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-kappaB gene network. Cell reports, 8 (5) , 1328-38More Information

Starczynowski, Daniel T  (2014). Errant innate immune signaling in del(5q) MDS. Blood, 124 (5) , 669-71More Information

Beverly, Levil J; Starczynowski, Daniel T  (2014). IRAK1: oncotarget in MDS and AML. Oncotarget, 5 (7) , 1699-700

Zhao, Jimmy L; Starczynowski, Daniel T  (2014). Role of microRNA-146a in normal and malignant hematopoietic stem cell function. Frontiers in genetics, 5, 219More Information

Rhyasen, Garrett W; Bolanos, Lyndsey; Starczynowski, Daniel T  (2013). Differential IRAK signaling in hematologic malignancies. Experimental hematology, 41 (12) , 1005-7More Information

Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi  (2013). Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica, 98 (9) , 1353-8More Information

Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T  (2013). Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer cell, 24 (1) , 90-104More Information

Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T  (2012). Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood, 120 (4) , 858-67More Information

Vercauteren, Suzanne M; Starczynowski, Daniel T; Sung, Sandy; McNeil, Kelly; Salski, Chris; Jensen, Clara-Lynn; Bruyere, Helene; Lam, Wan L; Karsan, Aly  (2012). T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. British journal of haematology, 156 (3) , 409-12

Fang, Jing; Varney, Melinda; Starczynowski, Daniel T  (2012). Implication of microRNAs in the pathogenesis of MDS. Current pharmaceutical design, 18 (22) , 3170-9

Starczynowski, Daniel T; Lockwood, William W; Deléhouzée, Sophie; Chari, Raj; Wegrzyn, Joanna; Fuller, Megan; Tsao, Ming-Sound; Lam, Stephen; Gazdar, Adi F; Lam, Wan L; Karsan, Aly  (2011). TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. The Journal of clinical investigation, 121 (10) , 4095-105More Information

Kuchenbauer, Florian; Mah, Sarah M; Heuser, Michael; McPherson, Andrew; Rüschmann, Jens; Rouhi, Arefeh; Berg, Tobias; Bullinger, Lars; Argiropoulos, Bob; Morin, Ryan D; Lai, David; Starczynowski, Daniel T; Karsan, Aly; Eaves, Connie J; Watahiki, Akira; Wang, Yuzhuo; Aparicio, Samuel A; Ganser, Arnold; Krauter, Jürgen; Döhner, Hartmut; Döhner, Konstanze; Marra, Marco A; Camargo, Fernando D; Palmqvist, Lars; Buske, Christian; Humphries, R Keith  (2011). Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood, 118 (12) , 3350-8More Information

Starczynowski, Daniel T; Vercauteren, Suzanne; Sung, Sandy; Brooks-Wilson, Angela; Lam, Wan L; Karsan, Aly  (2011). Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leukemia research, 35 (4) , 444-7More Information

Starczynowski, Daniel T; Kuchenbauer, Florian; Wegrzyn, Joanna; Rouhi, Arefeh; Petriv, Oleh; Hansen, Carl L; Humphries, R Keith; Karsan, Aly  (2011). MicroRNA-146a disrupts hematopoietic differentiation and survival. Experimental hematology, 39 (2) , 167-178.e4More Information

Starczynowski, Daniel T; Morin, Ryan; McPherson, Andrew; Lam, Jeff; Chari, Raj; Wegrzyn, Joanna; Kuchenbauer, Florian; Hirst, Martin; Tohyama, Kaoru; Humphries, R Keith; Lam, Wan L; Marra, Marco; Karsan, Aly  (2011). Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood, 117 (2) , 595-607More Information

Vercauteren, Suzanne M; Sung, Sandy; Starczynowski, Daniel T; Lam, Wan L; Bruyere, Helene; Horsman, Douglas E; Tsang, Peter; Leitch, Heather; Karsan, Aly  (2010). Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. American journal of clinical pathology, 134 (1) , 119-26More Information

Starczynowski, Daniel T; Karsan, Aly  (2010). Innate immune signaling in the myelodysplastic syndromes. Hematology/oncology clinics of North America, 24 (2) , 343-59More Information

Starczynowski, Daniel T; Karsan, Aly  (2010). Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q. Cell cycle (Georgetown, Tex.), 9 (5) , 855-6

Starczynowski, Daniel T; Kuchenbauer, Florian; Argiropoulos, Bob; Sung, Sandy; Morin, Ryan; Muranyi, Andrew; Hirst, Martin; Hogge, Donna; Marra, Marco; Wells, Richard A; Buckstein, Rena; Lam, Wan; Humphries, R Keith; Karsan, Aly  (2010). Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature medicine, 16 (1) , 49-58More Information

Starczynowski, Daniel T; Vercauteren, Suzanne; Telenius, Adele; Sung, Sandy; Tohyama, Kaoru; Brooks-Wilson, Angela; Spinelli, John J; Eaves, Connie J; Eaves, Allen C; Horsman, Douglas E; Lam, Wan L; Karsan, Aly  (2008). High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood, 112 (8) , 3412-24More Information

Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D  (2005). Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Oncogene, 24 (49) , 7355-68More Information

Kalaitzidis, Demetrios; Ok, John; Sulak, Lawrence; Starczynowski, Daniel T; Gilmore, Thomas D  (2004). Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells. Oncogene, 23 (45) , 7580-7More Information

Gilmore, Thomas D; Starczynowski, Daniel T; Kalaitzidis, Demetrios  (2004). RELevant gene amplification in B-cell lymphomas?. Blood, 103 (8) , 3243-4; author replyMore Information

Gilmore, Thomas D; Kalaitzidis, Demetrios; Liang, Mei-Chih; Starczynowski, Daniel T  (2004). The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene, 23 (13) , 2275-86More Information

Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D  (2003). Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells. Oncogene, 22 (44) , 6928-36More Information

Leonida, Mihaela D; Starczynowski, Daniel T; Waldman, Riva; Aurian-Blajeni, Benedict  (2003). Polymeric FAD used as enzyme-friendly mediator in lactate detection. Analytical and bioanalytical chemistry, 376 (6) , 832-7More Information

Gilmore, Thomas; Gapuzan, Maria-Emily; Kalaitzidis, Demetrios; Starczynowski, Daniel  (2002). Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer letters, 181 (1) , 1-9

Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A  (2014). p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-kappaB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche. Cell reports, 9 (6) , 2084-97More Information

Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT  (2016). Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome. Leukemia, 50, 85

Fang J, Liu X, Bolanos L, Barker B, Rigolino C, Cortelezzi A, Oliva EN, Cuzzola M, Grimes HL, Fontanillo C, Komurov K, MacBeth K, Starczynowski DT  (2016). A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes. Nature Medicine, 22 (7) , 727

Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI  (2015). IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget, 6 (41) , 43395

Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT  (2015). Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. Journal of Experimental Medicine, 212 (11) , 1967

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T  (2017). Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature Immunology, 18 (2) , 236-245More Information

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T  (2018). TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 (5) , 1250-1262More Information

Culver-Cochran, Ashley E; Starczynowski, Daniel T  (2018). Chronic innate immune signaling results in ubiquitination of splicing machinery. Cell cycle (Georgetown, Tex.), 1-4More Information

Kong, Fansheng; Liu, Zhiwei; Jain, Viral G; Shima, Kenjiro; Suzuki, Takuji; Muglia, Louis J; Starczynowski, Daniel T; Pasare, Chandrashekhar; Bhattacharyya, Sandip  (2017). Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages. Journal of immunology (Baltimore, Md. : 1950), 199 (10) , 3654-3667More Information

Barreyro, Laura; Chlon, Timothy M; Starczynowski, Daniel T  (2018). Chronic immune response dysregulation in MDS pathogenesis. Blood, 132 (15) , 1553-1560More Information

Wei, Yue; Zheng, Hong; Bao, Naran; Jiang, Shan; Bueso-Ramos, Carlos E; Khoury, Joseph; Class, Caleb; Lu, Yue; Lin, Kevin; Yang, Hui; Ganan-Gomez, Irene; Starczynowski, Daniel T; Do, Kim-Anh; Colla, Simona; Garcia-Manero, Guillermo  (2018). KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice. Blood advances, 2 (19) , 2491-2504More Information

Rawat, Radhika; Starczynowski, Daniel T; Ntziachristos, Panagiotis  (2019). Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease. Current opinion in cell biology, 58, 85-94More Information

Smith, Molly A; Choudhary, Gaurav S; Pellagatti, Andrea; Choi, Kwangmin; Bolanos, Lyndsey C; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Von Ahrens, Dagny; Pradhan, Kith; Steeples, Violetta; Kim, Sanghyun; Steidl, Ulrich; Walter, Matthew; Fraser, Iain D C; Kulkarni, Aishwarya; Salomonis, Nathan; Komurov, Kakajan; Boultwood, Jacqueline; Verma, Amit; Starczynowski, Daniel T  (2019). U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. Nature cell biologyMore Information

Varney, M E; Choi, K; Bolanos, L; Christie, S; Fang, J; Grimes, H L; Maciejewski, J P; Inoue, J-I; Starczynowski, D T  (2017). Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome. Leukemia, 31 (2) , 491-495More Information

Gañán-Gómez, I; Wei, Y; Starczynowski, D T; Colla, S; Yang, H; Cabrero-Calvo, M; Bohannan, Z S; Verma, A; Steidl, U; Garcia-Manero, G  (2015). Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes. Leukemia, 29 (7) , 1458-69More Information

Rhyasen, G W; Starczynowski, D T  (2015). IRAK signalling in cancer. British journal of cancer, 112 (2) , 232-7More Information

Wilson, I M; Vucic, E A; Enfield, K S S; Thu, K L; Zhang, Y A; Chari, R; Lockwood, W W; Radulovich, N; Starczynowski, D T; Banáth, J P; Zhang, M; Pusic, A; Fuller, M; Lonergan, K M; Rowbotham, D; Yee, J; English, J C; Buys, T P H; Selamat, S A; Laird-Offringa, I A; Liu, P; Anderson, M; You, M; Tsao, M S; Brown, C J; Bennewith, K L; MacAulay, C E; Karsan, A; Gazdar, A F; Lam, S; Lam, W L  (2014). EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene, 33 (36) , 4464-73More Information

Rhyasen, G W; Wunderlich, M; Tohyama, K; Garcia-Manero, G; Mulloy, J C; Starczynowski, D T  (2014). An MDS xenograft model utilizing a patient-derived cell line. Leukemia, 28 (5) , 1142-5More Information

Rhyasen, G W; Starczynowski, D T  (2012). Deregulation of microRNAs in myelodysplastic syndrome. Leukemia, 26 (1) , 13-22More Information

Sekeres, Mikkael A; Gore, Steven D; Stablein, Donald M; DiFronzo, Nancy; Abel, Gregory A; DeZern, Amy E; Troy, Jesse D; Rollison, Dana E; Thomas, John W; Waclawiw, Myron A; Liu, Jane Jijun; Al Baghdadi, Tareq; Walter, Matthew J; Bejar, Rafael; Gorak, Edward J; Starczynowski, Daniel T; Foran, James M; Cerhan, James R; Moscinski, Lynn C; Komrokji, Rami S; Deeg, H Joachim; Epling-Burnette, Pearlie K  (2019). The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes. Leukemia & lymphoma, 1-11More Information

Melgar, Katelyn; Walker, Morgan M; Jones, LaQuita M; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Jiang, Jiang-Kang; Wilson, Kelli M; Zhang, Xiaohu; Sutter, Patrick; Wang, Amy; Xu, Xin; Choi, Kwangmin; Tawa, Gregory; Lorimer, Donald; Abendroth, Jan; O'Brien, Eric; Hoyt, Scott B; Berman, Ellin; Famulare, Christopher A; Mulloy, James C; Levine, Ross L; Perentesis, John P; Thomas, Craig J; Starczynowski, Daniel T  (2019). Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Science translational medicine, 11 (508) More Information

Jones, LaQuita M; Melgar, Katelyn; Bolanos, Lyndsey; Hueneman, Kathleen; Walker, Morgan M; Jiang, Jian-Kang; Wilson, Kelli M; Zhang, Xiaohu; Shen, Jian; Jiang, Fan; Sutter, Patrick; Wang, Amy; Xu, Xin; Tawa, Gregory J; Hoyt, Scott B; Wunderlich, Mark; O'Brien, Eric; Perentesis, John P; Starczynowski, Daniel T; Thomas, Craig J  (2020). Targeting AML-associated FLT3 mutations with a type I kinase inhibitor. The Journal of clinical investigationMore Information

Niederkorn, Madeline; Hueneman, Kathleen; Choi, Kwangmin; Varney, Melinda E; Romano, Laurel; Pujato, Mario A; Greis, Kenneth D; Inoue, Jun-Ichiro; Meetei, Ruhikanta; Starczynowski, Daniel T  (2020). TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis. Cell reports, 30 (8) , 2776-2790.e6More Information

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T  (2020). Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 (5) , 535-545More Information

Laranjeira, Angelo Brunelli Albertoni; Kong, Tim; Snyder, Steven C; Fulbright, Mary C; Fisher, Daniel A C; Starczynowski, Daniel T; Oh, Stephen T  (2024). In vivo ablation of NFκB cascade effectors alleviates disease burden in myeloproliferative neoplasms. BloodMore Information

Venkatasubramanian, Meenakshi; Schwartz, Leya; Ramachandra, Nandini; Bennett, Joshua; Subramanian, Krithika R; Chen, Xiaoting; Gordon-Mitchell, Shanisha; Fromowitz, Ariel; Pradhan, Kith; Shechter, David; Sahu, Srabani; Heiser, Diane; Scherle, Peggy; Chetal, Kashish; Kulkarni, Aishwarya; Myers, Kasiani C; Weirauch, Matthew T; Grimes, H Leighton; Starczynowski, Daniel T; Verma, Amit; Salomonis, Nathan  (2024). Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation. bioRxiv : the preprint server for biologyMore Information

Riabov, Vladimir; Xu, Qingyu; Schmitt, Nanni; Streuer, Alexander; Ge, Guo; Bolanos, Lyndsey; Wunderlich, Mark; Jann, Johann-Christoph; Wein, Alina; Altrock, Eva; Demmerle, Marie; Mukherjee, Sanjay; Ali, Abdullah Mahmood; Rapp, Felicitas; Nowak, Verena; Weimer, Nadine; Obländer, Julia; Palme, Iris; Göl, Melda; Jawhar, Ahmed; Darwich, Ali; Wuchter, Patrick; Weiss, Christel; Raza, Azra; Foulks, Jason M; Starczynowski, Daniel T; Yang, Feng-Chun; Metzgeroth, Georgia; Steiner, Laurenz; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Nowak, Daniel  (2023). ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms. HaematologicaMore Information

Stahl, Maximilian; Bewersdorf, Jan Philipp; Xie, Zhuoer; Porta, Matteo Giovanni Della; Komrokji, Rami; Xu, Mina L; Abdel-Wahab, Omar; Taylor, Justin; Steensma, David P; Starczynowski, Daniel T; Sekeres, Mikkael A; Sanz, Guillermo; Sallman, David A; Roboz, Gail J; Platzbecker, Uwe; Patnaik, Mrinal M; Padron, Eric; Odenike, Olatoyosi; Nimer, Stephen D; Nazha, Aziz; Majeti, Ravi; Loghavi, Sanam; Little, Richard F; List, Alan F; Kim, Tae Kon; Hourigan, Christopher S; Hasserjian, Robert P; Halene, Stephanie; Griffiths, Elizabeth A; Gore, Steven D; Greenberg, Peter; Figueroa, Maria E; Fenaux, Pierre; Efficace, Fabio; DeZern, Amy E; Daver, Naval G; Churpek, Jane E; Carraway, Hetty E; Buckstein, Rena; Brunner, Andrew M; Boultwood, Jacqueline; Borate, Uma; Bejar, Rafael; Bennett, John M; Wei, Andrew H; Santini, Valeria; Savona, Michael R; Zeidan, Amer M  (2023). Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS). Blood reviews, 62, 101128More Information

Xie, Zhuoer; Starczynowski, Daniel T  (2023). Are DDX41 variants of unknown significance and pathogenic variants created equal?. Haematologica, 108 (11) , 2883-2885More Information

Gorak, Edward J; Otterstatter, Michael; Al Baghdadi, Tareq; Gillis, Nancy; Foran, James M; Liu, Jane Jijun; Bejar, Rafael; Gore, Steven D; Kroft, Steven H; Harrington, Alexandra; Saber, Wael; Starczynowski, Daniel; Rollison, Dana E; Zhang, Ling; Moscinski, Lynn; Wilson, Steffanie; Thompson, Jason; Borchert, Christine; Sherman, Seth; Hebert, Donnie; Walker, Mary Ellen; Padron, Eric; DeZern, Amy E; Sekeres, Mikkael A  (2023). Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies. Blood advances, 7 (20) , 6120-6129More Information

Muto, Tomoya; Walker, Callum S; Agarwal, Puneet; Vick, Eric; Sampson, Avery; Choi, Kwangmin; Niederkorn, Madeline; Ishikawa, Chiharu; Hueneman, Kathleen; Varney, Melinda; Starczynowski, Daniel T  (2023). Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation. Haematologica, 108 (10) , 2715-2729More Information

Bennett, Joshua; Ishikawa, Chiharu; Agarwal, Puneet; Yeung, Jennifer; Sampson, Avery; Uible, Emma; Vick, Eric; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Kolt, Amal; Choi, Kwangmin; Volk, Andrew; Greis, Kenneth D; Rosenbaum, Jan; Hoyt, Scott B; Thomas, Craig J; Starczynowski, Daniel T  (2023). Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. Blood, 142 (11) , 989-1007More Information

Dean, Sarai T; Ishikawa, Chiharu; Zhu, Xiaoqin; Walulik, Sean; Nixon, Timothy; Jordan, Jessica K; Henderson, Samantha; Wyder, Michael; Salomonis, Nathan; Wunderlich, Mark; Greis, Kenneth D; Starczynowski, Daniel T; Volk, Andrew G  (2023). Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development. Blood advances, 7 (17) , 4822-4837More Information

Marion, William; Koppe, Tiago; Chen, Chun-Chin; Wang, Dahai; Frenis, Katie; Fierstein, Sara; Sensharma, Prerana; Aumais, Olivia; Peters, Michael; Ruiz-Torres, Sonya; Chihanga, Tafadzwa; Boettcher, Steffen; Shimamura, Akiko; Bauer, Daniel E; Schlaeger, Thorsten; Wells, Susanne I; Ebert, Benjamin L; Starczynowski, Daniel; da Rocha, Edroaldo Lummertz; Rowe, R Grant  (2023). RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia. Leukemia, 37 (8) , 1698-1708More Information

Bewersdorf, Jan Philipp; Xie, Zhuoer; Bejar, Rafael; Borate, Uma; Boultwood, Jacqueline; Brunner, Andrew M; Buckstein, Rena; Carraway, Hetty E; Churpek, Jane E; Daver, Naval G; Porta, Matteo Giovanni Della; DeZern, Amy E; Fenaux, Pierre; Figueroa, Maria E; Gore, Steven D; Griffiths, Elizabeth A; Halene, Stephanie; Hasserjian, Robert P; Hourigan, Christopher S; Kim, Tae Kon; Komrokji, Rami; Kuchroo, Vijay K; List, Alan F; Loghavi, Sanam; Majeti, Ravindra; Odenike, Olatoyosi; Patnaik, Mrinal M; Platzbecker, Uwe; Roboz, Gail J; Sallman, David A; Santini, Valeria; Sanz, Guillermo; Sekeres, Mikkael A; Stahl, Maximilian; Starczynowski, Daniel T; Steensma, David P; Taylor, Justin; Abdel-Wahab, Omar; Xu, Mina L; Savona, Michael R; Wei, Andrew H; Zeidan, Amer M  (2023). Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS). Blood reviews, 60, 101072More Information

Stahl, Maximilian; Abdel-Wahab, Omar; Wei, Andrew H; Savona, Michael R; Xu, Mina L; Xie, Zhuoer; Taylor, Justin; Starczynowski, Daniel; Sanz, Guillermo F; Sallman, David A; Santini, Valeria; Roboz, Gail J; Patnaik, Mrinal M; Padron, Eric; Odenike, Olatoyosi; Nazha, Aziz; Nimer, Stephen D; Majeti, Ravindra; Little, Richard F; Gore, Steven; List, Alan F; Kutchroo, Vijay; Komrokji, Rami S; Kim, Tae Kon; Kim, Nina; Hourigan, Christopher S; Hasserjian, Robert P; Halene, Stephanie; Griffiths, Elizabeth A; Greenberg, Peter L; Figueroa, Maria; Fenaux, Pierre; Efficace, Fabio; DeZern, Amy E; Della Porta, Matteo G; Daver, Naval G; Churpek, Jane E; Carraway, Hetty E; Brunner, Andrew M; Borate, Uma; Bennett, John M; Bejar, Rafael; Boultwood, Jacqueline; Loghavi, Sanam; Bewersdorf, Jan Philipp; Platzbecker, Uwe; Steensma, David P; Sekeres, Mikkael A; Buckstein, Rena J; Zeidan, Amer M  (2023). An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS. Blood advances, 7 (12) , 2709-2714More Information

Zeidan, Amer M; Bewersdorf, Jan Philipp; Buckstein, Rena; Sekeres, Mikkael A; Steensma, David P; Platzbecker, Uwe; Loghavi, Sanam; Boultwood, Jacqueline; Bejar, Rafael; Bennett, John M; Borate, Uma; Brunner, Andrew M; Carraway, Hetty; Churpek, Jane E; Daver, Naval G; Della Porta, Matteo; DeZern, Amy E; Efficace, Fabio; Fenaux, Pierre; Figueroa, Maria E; Greenberg, Peter; Griffiths, Elizabeth A; Halene, Stephanie; Hasserjian, Robert P; Hourigan, Christopher S; Kim, Nina; Kim, Tae Kon; Komrokji, Rami S; Kutchroo, Vijay; List, Alan F; Little, Richard F; Majeti, Ravi; Nazha, Aziz; Nimer, Stephen D; Odenike, Olatoyosi; Padron, Eric; Patnaik, Mrinal M; Roboz, Gail J; Sallman, David A; Sanz, Guillermo; Stahl, Maximilian; Starczynowski, Daniel T; Taylor, Justin; Xie, Zhuoer; Xu, Mina; Savona, Michael R; Wei, Andrew H; Abdel-Wahab, Omar; Santini, Valeria  (2022). Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes. Leukemia, 36 (12) , 2939-2946More Information

Yeaton, Anna; Cayanan, Geraldine; Loghavi, Sanam; Dolgalev, Igor; Leddin, Emmett M; Loo, Christian E; Torabifard, Hedieh; Nicolet, Deedra; Wang, Jingjing; Corrigan, Kate; Paraskevopoulou, Varvara; Starczynowski, Daniel T; Wang, Eric; Abdel-Wahab, Omar; Viny, Aaron D; Stone, Richard M; Byrd, John C; Guryanova, Olga A; Kohli, Rahul M; Cisneros, G Andrés; Tsirigos, Aristotelis; Eisfeld, Ann-Kathrin; Aifantis, Iannis; Guillamot, Maria  (2022). The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation. Cancer discovery, 12 (10) , 2392-2413More Information

Choudhary, Gaurav S; Pellagatti, Andrea; Agianian, Bogos; Smith, Molly A; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Sahu, Srabani; Pandey, Sanjay; Shah, Nishi; Aluri, Srinivas; Aggarwal, Ritesh; Aminov, Sarah; Schwartz, Leya; Steeples, Violetta; Booher, Robert N; Ramachandra, Murali; Samson, Maria; Carbajal, Milagros; Pradhan, Kith; Bowman, Teresa V; Pillai, Manoj M; Will, Britta; Wickrema, Amittha; Shastri, Aditi; Bradley, Robert K; Martell, Robert E; Steidl, Ulrich G; Gavathiotis, Evripidis; Boultwood, Jacqueline; Starczynowski, Daniel T; Verma, Amit  (2022). Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations. eLife, 11More Information

Zhang, Yang; Chen, Xiaoyi; Wang, Huamin; Gordon-Mitchell, Shanisha; Sahu, Srabani; Bhagat, Tushar D; Choudhary, Gaurav; Aluri, Srinivas; Pradhan, Kith; Sahu, Plabani; Carbajal, Milagros; Zhang, Hui; Agarwal, Beamon; Shastri, Aditi; Martell, Robert; Starczynowski, Daniel; Steidl, Ulrich; Maitra, Anirban; Verma, Amit  (2022). Correction: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer. Journal of hematology & oncology, 15 (1) , 100More Information

Zhang, Yang; Chen, Xiaoyi; Wang, Huamin; Gordon-Mitchell, Shanisha; Sahu, Srabani; Bhagat, Tushar D; Choudhary, Gaurav; Aluri, Srinivas; Pradhan, Kith; Sahu, Plabani; Carbajal, Milagros; Zhang, Hui; Agarwal, Beamon; Shastri, Aditi; Martell, Robert; Starczynowski, Daniel; Steidl, Ulrich; Maitra, Anirban; Verma, Amit  (2022). Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer. Journal of hematology & oncology, 15 (1) , 70More Information

Jones, LaQuita M; Starczynowski, Daniel T  (2022). IKAROS and MENIN in synergy in AML. Nature cancer, 3 (5) , 528-529More Information

Barreyro, Laura; Sampson, Avery M; Ishikawa, Chiharu; Hueneman, Kathleen M; Choi, Kwangmin; Pujato, Mario A; Chutipongtanate, Somchai; Wyder, Michael; Haffey, Wendy D; O'Brien, Eric; Wunderlich, Mark; Ramesh, Vighnesh; Kolb, Ellen M; Meydan, Cem; Neelamraju, Yaseswini; Bolanos, Lyndsey C; Christie, Susanne; Smith, Molly A; Niederkorn, Madeline; Muto, Tomoya; Kesari, Santosh; Garrett-Bakelman, Francine E; Bartholdy, Boris; Will, Britta; Weirauch, Matthew T; Mulloy, James C; Gul, Zartash; Medlin, Stephen; Kovall, Rhett A; Melnick, Ari M; Perentesis, John P; Greis, Kenneth D; Nurmemmedov, Elmar; Seibel, William L; Starczynowski, Daniel T  (2022). Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Science translational medicine, 14 (635) , eabb7695More Information

Azhar, Mohammad; Kincaid, Zachary; Kesarwani, Meenu; Ahmed, Arhama; Wunderlich, Mark; Latif, Tahir; Starczynowski, Daniel; Azam, Mohammad  (2022). Momelotinib is a highly potent inhibitor of FLT3-mutant AML. Blood advances, 6 (4) , 1186-1192More Information

Muto, Tomoya; Guillamot, Maria; Yeung, Jennifer; Fang, Jing; Bennett, Joshua; Nadorp, Bettina; Lasry, Audrey; Redondo, Luna Zea; Choi, Kwangmin; Gong, Yixiao; Walker, Callum S; Hueneman, Kathleen; Bolanos, Lyndsey C; Barreyro, Laura; Lee, Lynn H; Greis, Kenneth D; Vasyliev, Nikita; Khodadadi-Jamayran, Alireza; Nudler, Evgeny; Lujambio, Amaia; Lowe, Scott W; Aifantis, Iannis; Starczynowski, Daniel T  (2022). TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell stem cell, 29 (2) , 298-314.e9More Information

Niederkorn, Madeline; Ishikawa, Chiharu; M Hueneman, Kathleen; Bartram, James; Stepanchick, Emily; R Bennett, Joshua; E Culver-Cochran, Ashley; Bolanos, Lyndsey C; Uible, Emma; Choi, Kwangmin; Wunderlich, Mark; Perentesis, John P; M Chlon, Timothy; Filippi, Marie-Dominique; Starczynowski, Daniel T  (2022). The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia, 36 (2) , 438-451More Information

Bennett, Joshua; Starczynowski, Daniel T  (2022). IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies. Current opinion in hematology, 29 (1) , 8-19More Information

Aoyagi, Yasushige; Hayashi, Yoshihiro; Harada, Yuka; Choi, Kwangmin; Matsunuma, Natsumi; Sadato, Daichi; Maemoto, Yuki; Ito, Akihiro; Yanagi, Shigeru; Starczynowski, Daniel T; Harada, Hironori  (2022). Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes. Cancer discovery, 12 (1) , 250-269More Information

Chlon, Timothy M; Stepanchick, Emily; Hershberger, Courtney E; Daniels, Noah J; Hueneman, Kathleen M; Kuenzi Davis, Ashley; Choi, Kwangmin; Zheng, Yi; Gurnari, Carmelo; Haferlach, Torsten; Padgett, Richard A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T  (2021). Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell stem cell, 28 (11) , 1966-1981.e6More Information

Agarwal, Puneet; Li, Hui; Choi, Kwangmin; Hueneman, Kathleen; He, Jianbo; Welner, Robert S; Starczynowski, Daniel T; Bhatia, Ravi  (2021). TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling. Cell reports, 36 (2) , 109386More Information

Trowbridge, Jennifer J; Starczynowski, Daniel T  (2021). Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS. The Journal of experimental medicine, 218 (7) More Information

Wang, Tiansu; Pine, Allison R; Kotini, Andriana G; Yuan, Han; Zamparo, Lee; Starczynowski, Daniel T; Leslie, Christina; Papapetrou, Eirini P  (2021). Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. Cell stem cell, 28 (6) , 1074-1089.e7More Information

Serrano-Lopez, Juana; Hegde, Shailaja; Kumar, Sachin; Serrano, Josefina; Fang, Jing; Wellendorf, Ashley M; Roche, Paul A; Rangel, Yamileth; Carrington, Leolene J; Geiger, Hartmut; Grimes, H Leighton; Luther, Sanjiv; Maillard, Ivan; Sanchez-Garcia, Joaquin; Starczynowski, Daniel T; Cancelas, Jose A  (2021). Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife, 10More Information

Smith, Molly A; Culver-Cochran, Ashley E; Adelman, Emmalee R; Rhyasen, Garrett W; Ma, Averil; Figueroa, Maria E; Starczynowski, Daniel T  (2020). TNFAIP3 Plays a Role in Aging of the Hematopoietic System. Frontiers in immunology, 11, 536442More Information

Schieber, Michael; Marinaccio, Christian; Bolanos, Lyndsey C; Haffey, Wendy D; Greis, Kenneth D; Starczynowski, Daniel T; Crispino, John D  (2020). FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome. Blood cancer journal, 10 (10) , 98More Information

Starczynowski, Daniel T  (2020). HHEX expression drives AML development. Blood, 136 (14) , 1575-1576More Information

Niederkorn, Madeline; Agarwal, Puneet; Starczynowski, Daniel T  (2020). TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease. Experimental hematology, 90, 18-29More Information

Niederkorn, Madeline; Starczynowski, Daniel T  (2017). GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis. Cell stem cell, 20 (5) , 579-581More Information

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T  (2017). Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature immunology, 18 (2) , 236-245More Information

Shimizu, Ryo; Muto, Tomoya; Aoyama, Kazumasa; Choi, Kwangmin; Takeuchi, Masahiro; Koide, Shuhei; Hasegawa, Nagisa; Isshiki, Yusuke; Togasaki, Emi; Kawajiri-Manako, Chika; Nagao, Yuhei; Tsukamoto, Shokichi; Sakai, Shio; Takeda, Yusuke; Mimura, Naoya; Ohwada, Chikako; Sakaida, Emiko; Iseki, Tohru; Starczynowski, Daniel T; Iwama, Atsushi; Yokote, Koutaro; Nakaseko, Chiaki  (2016). Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia. Leukemia research, 50, 85-94More Information

Fang, Jing; Liu, Xiaona; Bolanos, Lyndsey; Barker, Brenden; Rigolino, Carmela; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Grimes, H Leighton; Fontanillo, Celia; Komurov, Kakajan; MacBeth, Kyle; Starczynowski, Daniel T  (2016). A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes. Nature medicine, 22 (7) , 727-34More Information

Adams, Allie K; Bolanos, Lyndsey C; Dexheimer, Phillip J; Karns, Rebekah A; Aronow, Bruce J; Komurov, Kakajan; Jegga, Anil G; Casper, Keith A; Patil, Yash J; Wilson, Keith M; Starczynowski, Daniel T; Wells, Susanne I  (2015). IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget, 6 (41) , 43395-407More Information

Varney, Melinda E; Niederkorn, Madeline; Konno, Hiroyasu; Matsumura, Takayuki; Gohda, Jin; Yoshida, Nobuaki; Akiyama, Taishin; Christie, Susanne; Fang, Jing; Miller, David; Jerez, Andres; Karsan, Aly; Maciejewski, Jaroslaw P; Meetei, Ruhikanta A; Inoue, Jun-ichiro; Starczynowski, Daniel T  (2015). Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. The Journal of experimental medicine, 212 (11) , 1967-85More Information

Fang, Jing; Starczynowski, Daniel T  (2015). Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q). Molecular & cellular oncology, 2 (4) , e1014219More Information

Gentner, Bernhard; Pochert, Nicole; Rouhi, Arefeh; Boccalatte, Francesco; Plati, Tiziana; Berg, Tobias; Sun, Su Ming; Mah, Sarah M; Mirkovic-Hösle, Milijana; Ruschmann, Jens; Muranyi, Andrew; Leierseder, Simon; Argiropoulos, Bob; Starczynowski, Daniel T; Karsan, Aly; Heuser, Michael; Hogge, Donna; Camargo, Fernando D; Engelhardt, Stefan; Döhner, Hartmut; Buske, Christian; Jongen-Lavrencic, Mojca; Naldini, Luigi; Humphries, R Keith; Kuchenbauer, Florian  (2015). MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Experimental hematology, 43 (10) , 858-868.e7More Information

Varney, Melinda E; Melgar, Katelyn; Niederkorn, Madeline; Smith, Molly; Barreyro, Laura; Starczynowski, Daniel T  (2015). Deconstructing innate immune signaling in myelodysplastic syndromes. Experimental hematology, 43 (8) , 587-598More Information