Tom B Thompson , PhD

The focus of my laboratory is divided into two areas of investigation where I study the structural and functional aspects of TGFbeta family signaling and regulation along with the structures of apolipoproteins and how this relates to HDL particles and other related biological functions.  The laboratory uses a combination of structural techniques including X-ray crstallography, small angle X-ray scattering coupled with biophysical and biochemical experiments.
For more information please visit the Thompson Lab website at:
http://www.tomthompsonlab.com/

B.S.: Northern Illinois University Dekalb IL, 1992 (Chemistry)

M.S.: Northern Illinois University Dekalb IL, 1995 (Biochemistry)

PhD: University of Wisconsin Madison WI, 2000 (Biochemistry)

Post Doc: Nortwestern University Chicago, 2005

Click here to visit the Thompson lab website

Grant: #GM084186 Investigators:Tom Thompson 04-01-2008 -03-31-2013 National Institute of Health-General Medicine Structural basis of antagonism within the TGFbeta superfamily Role:PI 1,628,000 Active Type:Grant Level:National

Grant: #GM098458 Investigators:Tom Thompson and Sean Davidson 09-01-2011 -06-30-2015 National Institute of Health-General Medicine Structure/Function Studies of Apolipoproteins Role:co-PI 1,192,000 Active Type:Grant

Grant: #HD033438 Investigators:Martin Mazuk, Tom Thompson, Mandy Katz-Jaffe 08-05-2011 -05-31-2016 National Institutes of Health, NIHCD Analysis of Reproductive Function Using Transgenic Mice Role:co-PI 2,055,000 Active Type:Grant

Grant: #240087 Investigators:Tom Thompson 07-01-2012 -06-30-2015 Muscular Dystrophy Association Structural studies of myostatin inhibitors Role:PI 300,000 Active Type:Grant

Grant: #0635097N Investigators:Thompson, Thomas 07-01-2006 -06-30-2010 American Heart Association - National Chapter Structure/Function Studies of Myostatin Antagonism Through Propeptide Interactions Role:PI $260,000.00 Closed Level:Private Non-Profit

Grant: #R01 GM084186 Investigators:Thompson, Thomas 04-01-2008 -03-31-2014 National Institute of General Medical Sciences Structural Basis of Antagonism within the TgfB- Superfamily Role:PI $1,562,239.00 Active Level:Federal

Grant: #MDA 10072 / 93887 Investigators:Thompson, Thomas 07-01-2008 -06-30-2011 Muscular Dystrophy Association Towards the Development of Alternative Anti-Myostatin Therapeutics Role:PI $287,100.00 Closed Level:Private Non-Profit

Grant: #R01 GM098458 Investigators:Davidson, William; Thompson, Thomas 09-01-2011 -06-30-2015 National Institute of General Medical Sciences A High Resolution Structural Approach to Understanding HDL Biogenesis Role:Collaborator $884,460.00 Active Level:Federal

Grant: #PO 101565366 / 2R01 HD033438-16A1 Investigators:Thompson, Thomas 08-05-2011 -05-31-2016 National Institute of Child Health and Human Development Analysis of Reproductive Function Using Transgenic Mice Role:PI $283,929.00 Active Level:Federal

Grant: #12PRE11790027 Investigators:Thompson, Thomas; Walker, Ryan 07-01-2012 -06-30-2014 American Heart Association - Great Rivers Affiliate Determination of GASP1 Structural Architecture Required for Mystatin Antagonism Role:Collaborator $50,000.00 Active Level:Private Non-Profit

Grant: #MDA240087 Investigators:Thompson, Thomas 08-01-2012 -07-31-2015 Muscular Dystrophy Association Structural Studies of Myostatin Inhibitors Role:PI $110,000.00 Active Level:Private Non-Profit

Grant: #SAXS Evaluation Agmt Investigators:Thompson, Thomas 11-25-2013 -05-24-2014 Pfizer, Inc. SAXS Evaluation Agreement Role:PI $72,000.00 Active Level:Industry

Grant: #14PRE20480142 Investigators:Nolan, Kristof; Thompson, Thomas 07-01-2014 -06-30-2016 American Heart Association - Great Rivers Affiliate Molecular Determinants Required for DAN-family Antagonism of BMP Signaling Role:Collaborator $26,000.00 Awarded Level:Private Non-Profit

Grant: #133185 / R01 DK070858 Investigators:Thompson, Thomas 04-01-2014 -03-31-2019 National Inst of Diabetes and Digestive and Kidney Disease Molecular basis of digestive system development in Xenopus Role:PI $19,039.00 Active Level:Federal

Grant: #CHMC 134164 / T32 HL124204 Investigators:Castleberry, Mark; Thompson, Thomas 01-12-2017 -01-11-2018 National Heart, Lung and Blood Institute Understanding Cardiovascular Disease Mechanisms Role:Collaborator $32,260.00 Active Level:Federal

Grant: #MUHC 5536 / DOD Investigators:Thompson, Thomas 05-15-2014 -08-15-2016 Department of Defense Development of CD 109 as a novel TGF-beta antagonist and anti-fibrotic agent for the treatment of scleroderma Role:PI $10,000.00 Awarded Level:Federal

Grant: #134164 / T32 HL125204 Investigators:Castleberry, Mark; Thompson, Thomas 01-01-2018 -01-11-2019 National Heart, Lung and Blood Institute Understanding Cardiovascular Disease Mechanisms Role:PI $32,728.00 Awarded Level:Federal

Grant: #1R01GM114640-01 Investigators:Thompson, Thomas 04-01-2015 -01-31-2019 National Institute of General Medical Sciences Structure-Function Investigation of DAN-mediated BMP Antagonism Role:PI $446,004.00 Awarded Level:Federal

Grant: #18PRE33990317 Investigators:Goebel, Erich; Thompson, Thomas 07-01-2018 -06-30-2020 American Heart Association - National Chapter Characterization of the Growth and Differentiation Factor 11 Ternary Receptor Assembly Role:Collaborator $53,688.00 Active Level:Private Non-Profit

Grant: #18PRE33990312 Investigators:McCoy, Jason; Thompson, Thomas 07-01-2018 -06-30-2020 American Heart Association - National Chapter Growth Differentiation Factor 8 (GDF8) Antagonism by Growth Associated Serum Protein (GASP) Role:Collaborator $53,688.00 Active Level:Private Non-Profit

Grant: #R01GM127726 Investigators:Thompson, Thomas 09-20-2018 -08-31-2022 National Institute of General Medical Sciences Structural insight into the signaling and regulation of GDF8 and GDF11 Role:PI $386,478.00 Awarded Level:Federal

Grant: #233628 sub Gates Fdn OPP1203044 Investigators:Thompson, Thomas 11-21-2018 -10-31-2019 Bill & Melinda Gates Foundation A pipeline to screen and validate MISR2 agonists as contraceptives that inhibit primordial follicles Role:PI $29,835.00 Awarded Level:Private Non-Profit

Grant: #R35 GM134923 Investigators:Thompson, Thomas 02-01-2020 -01-31-2025 National Institute of General Medical Sciences Structural/functional characterization of TGFß superfamily signaling and regulation Role:PI $312,530.00 Awarded Level:Federal

Grant: #R0AG072087 Investigators:Thompson, Thomas 09-15-2020 -05-31-2025 National Institute on Aging Regulation of GDF11 by extracellular mechanisms (Formerly A cross-systems analysis of systemic regulators of aging and regenerative biology for the P01 submission) Role:PI $587,416.00 Awarded Level:Federal

Grant: #R01HD105818 Investigators:Thompson, Thomas 08-18-2021 -05-31-2026 National Institute of Child Health and Human Development Structure-function analysis of Mullerian Inhibiting Substance (MIS) Role:PI 419866.00 Awarded Level:Federal

Grant: #S10OD030388 Investigators:Thompson, Thomas 09-01-2021 -08-31-2022 Office of the Director, National Institutes of Health Glacios 200 kV cryogenic transmission electron microscope (cryo-TEM) Role:PI 2000000.00 Awarded Level:Federal

Grant: #R01NS127074 Investigators:Luo, Yu; Thompson, Thomas 05-15-2022 -04-30-2027 National Institute of Neurological Disorders and Stroke The role TGFb Signaling pathway in microglia and astrocytes homeostasis and cellular interactions Role:Collaborator 553741.00 Awarded Level:Federal

04-01-2023 -03-31-2024 McGill University Function of immunoglobulin superfamily, member 1 in health and disease Role:PI 26373.22 Hold Level:Higher Education

04-01-2023 -03-31-2024 McGill University Function of immunoglobulin superfamily, member 1 in health and disease Role:PI 26373.22 Hold Level:Higher Education

01-01-2024 -12-31-2025 American Heart Association - National Chapter Characterization of the Molecular Mechanism of Erythroferrone Antagonism and Specificity Role:PI 33694.00 Hold Level:Non Profit

01-01-2024 -12-31-2025 American Heart Association - National Chapter Characterization of the Molecular Mechanism of Erythroferrone Antagonism and Specificity Role:PI 33694.00 Hold Level:Non Profit

Grant: #R35GM134923 Renewal Investigators:Thompson, Thomas 12-01-2024 -11-30-2029 National Institute of General Medical Sciences Structural/functional characterization of TGFB superfamily signaling and regulation Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Kattamuri, Chandramohan; Luedeke, David M; Nolan, Kristof; Rankin, Scott A; Greis, Kenneth D; Zorn, Aaron M; Thompson, Thomas B (2012. ) Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers.Journal of molecular biology, , 424 (5 ) ,313-27 More Information

Zhang, Fuming; Beaudet, Julie M; Luedeke, David M; Walker, Ryan G; Thompson, Thomas B; Linhardt, Robert J (2012. ) Analysis of the interaction between heparin and follistatin and heparin and follistatin-ligand complexes using surface plasmon resonance.Biochemistry, , 51 (34 ) ,6797-803 More Information

Cash, Jennifer N; Angerman, Elizabeth B; Keutmann, Henry T; Thompson, Thomas B (2012. ) Characterization of follistatin-type domains and their contribution to myostatin and activin a antagonism.Molecular endocrinology (Baltimore, Md.), , 26 (7 ) ,1167-78 More Information

Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B (2012. ) The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.Structure (London, England : 1993), , 20 (5 ) ,767-79 More Information

Kattamuri, Chandramohan; Luedeke, David M; Thompson, Thomas B (2012. ) Expression and purification of recombinant protein related to DAN and cerberus (PRDC).Protein expression and purification, , 82 (2 ) ,389-95 More Information

Cash, Jennifer N; Angerman, Elizabeth B; Kattamuri, Chandramohan; Nolan, Kristof; Zhao, Huaying; Sidis, Yisrael; Keutmann, Henry T; Thompson, Thomas B (2012. ) Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.The Journal of biological chemistry, , 287 (2 ) ,1043-53 More Information

Deng, Xiaodi; Davidson, W Sean; Thompson, Thomas B (2012. ) Improving the diffraction of apoA-IV crystals through extreme dehydration.Acta crystallographica. Section F, Structural biology and crystallization communications, , 68 (Pt 1 ) ,105-10 More Information

Syed, Khajamohiddin; Kattamuri, Chandramohan; Thompson, Thomas B; Yadav, Jagjit S (2011. ) Cytochrome b? reductase-cytochrome b? as an active P450 redox enzyme system in Phanerochaete chrysosporium: atypical properties and in vivo evidence of electron transfer capability to CYP63A2.Archives of biochemistry and biophysics, , 509 (1 ) ,26-32 More Information

Cash, Jennifer N; Rejon, Carlis A; McPherron, Alexandra C; Bernard, Daniel J; Thompson, Thomas B (2009. ) The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding.The EMBO journal, , 28 (17 ) ,2662-76 More Information

Stamler, Robin; Keutmann, Henry T; Sidis, Yisrael; Kattamuri, Chandramohan; Schneyer, Alan; Thompson, Thomas B (2008. ) The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity.The Journal of biological chemistry, , 283 (47 ) ,32831-8 More Information

Davidson, W Sean; Thompson, Thomas B (2007. ) The structure of apolipoprotein A-I in high density lipoproteins.The Journal of biological chemistry, , 282 (31 ) ,22249-53 More Information

Cook, Robert W; Thompson, Thomas B; Kurup, Sudhi P; Jardetzky, Theodore S; Woodruff, Teresa K (2005. ) Structural basis for a functional antagonist in the transforming growth factor beta superfamily.The Journal of biological chemistry, , 280 (48 ) ,40177-86 More Information

Thompson, Thomas B; Lerch, Thomas F; Cook, Robert W; Woodruff, Teresa K; Jardetzky, Theodore S (2005. ) The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding.Developmental cell, , 9 (4 ) ,535-43 More Information

Yuan, Ping; Thompson, Thomas B; Wurzburg, Beth A; Paterson, Reay G; Lamb, Robert A; Jardetzky, Theodore S (2005. ) Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.Structure (London, England : 1993), , 13 (5 ) ,803-15 More Information

Thompson, Thomas B; Cook, Robert W; Chapman, Stacey C; Jardetzky, Theodore S; Woodruff, Teresa K (2004. ) Beta A versus beta B: is it merely a matter of expression?.Molecular and cellular endocrinology, , 225 (1-2 ) ,9-17 More Information

Thompson, Thomas B; Katayama, Kinya; Watanabe, Kenji; Hutchinson, C Richard; Rayment, Ivan (2004. ) Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.The Journal of biological chemistry, , 279 (36 ) ,37956-63 More Information

Cook, Robert W; Thompson, Thomas B; Jardetzky, Theodore S; Woodruff, Teresa K (2004. ) Molecular biology of inhibin action.Seminars in reproductive medicine, , 22 (3 ) ,269-76 More Information

Thompson, Thomas B; Woodruff, Teresa K; Jardetzky, Theodore S (2003. ) Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.The EMBO journal, , 22 (7 ) ,1555-66 More Information

Bauer, C B; Fonseca, M V; Holden, H M; Thoden, J B; Thompson, T B; Escalante-Semerena, J C; Rayment, I (2001. ) Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP. Biochemistry, , 40 (2 ) ,361-74

Thomas, M G; Thompson, T B; Rayment, I; Escalante-Semerena, J C (2000. ) Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation.The Journal of biological chemistry, , 275 (36 ) ,27576-86 More Information

Thompson, T B; Garrett, J B; Taylor, E A; Meganathan, R; Gerlt, J A; Rayment, I (2000. ) Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. Biochemistry, , 39 (35 ) ,10662-76

Thompson, T B; Thomas, M G; Escalante-Semerena, J C; Rayment, I (1999. ) Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site. Biochemistry, , 38 (40 ) ,12995-3005

Thompson, T B; Thomas, M G; Escalante-Semerena, J C; Rayment, I (1998. ) Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution,.Biochemistry, , 37 (21 ) ,7686-95 More Information

Fisher, A J; Thompson, T B; Thoden, J B; Baldwin, T O; Rayment, I (1996. ) The 1.5-A resolution crystal structure of bacterial luciferase in low salt conditions. The Journal of biological chemistry, , 271 (36 ) ,21956-68

Thompson, T B; Chou, K C; Zheng, C (1995. ) Neural network prediction of the HIV-1 protease cleavage sites.Journal of theoretical biology, , 177 (4 ) ,369-79 More Information

Thompson, T B; Chou, K C; Zheng, C (1995. ) Analysis of the loop-helix interaction in bundle motif protein structures. Journal of protein chemistry, , 14 (7 ) ,559-66

Cash, Jennifer N; Angerman, Elizabeth B; Kirby, R Jason; Merck, Lisa; Seibel, William L; Wortman, Matthew D; Papoian, Ruben; Nelson, Sandra; Thompson, Thomas B (2013. ) Development of a Small-Molecule Screening Method for Inhibitors of Cellular Response to Myostatin and Activin A.Journal of biomolecular screening, , More Information

Peng, Jia; Li, Qinglei; Wigglesworth, Karen; Rangarajan, Adithya; Kattamuri, Chandramohan; Peterson, Randall T; Eppig, John J; Thompson, Thomas B; Matzuk, Martin M (2013. ) Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions.Proceedings of the National Academy of Sciences of the United States of America, , 110 (8 ) ,E776-85 More Information

Deng, Xiaodi; Morris, Jamie; Chaton, Catherine; Schröder, Gunnar F; Davidson, W Sean; Thompson, Thomas B (2013. ) Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability.The Journal of biological chemistry, , 288 (7 ) ,4854-66 More Information

Nolan, Kristof; Kattamuri, Chandramohan; Luedeke, David M; Deng, Xiaodi; Jagpal, Amrita; Zhang, Fuming; Linhardt, Robert J; Kenny, Alan P; Zorn, Aaron M; Thompson, Thomas B (2013. ) Structure of Protein Related to Dan and Cerberus: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism.Structure (London, England : 1993), , More Information

Nolan, Kristof; Thompson, Thomas B (2014. ) The DAN family: Modulators of TGF-? signaling and beyond.Protein science : a publication of the Protein Society, , More Information

Rodgers, Buel D; Wiedeback, Benjamin D; Hoversten, Knut E; Jackson, Melissa F; Walker, Ryan G; Thompson, Thomas B (2014. ) Myostatin stimulates, not inihibits, C2C12 myoblast proliferation.Endocrinology, , 155 (3 ) ,670-5 More Information

Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean (2014. ) The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering.The Journal of biological chemistry, , 289 (9 ) ,5596-608 More Information

Rejon, Carlis A; Hancock, Mark A; Li, Yining N; Thompson, Thomas B; Hébert, Terence E; Bernard, Daniel J (2013. ) Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells.Cellular signalling, , 25 (12 ) ,2717-26 More Information

Peng, Jia; Li, Qinglei; Wigglesworth, Karen; Rangarajan, Adithya; Kattamuri, Chandramohan; Peterson, Randall T; Eppig, John J; Thompson, Thomas B; Matzuk, Martin M (2013. ) Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions. Proceedings of the National Academy of Sciences of the United States of America, , 110 (25 ) ,E2258

Walker, Ryan G; Thompson, Thomas B (2015. ) Fibronectin-based scaffold domain proteins that bind myostatin: a patent evaluation of WO2014043344.Expert opinion on therapeutic patents, , 25 (5 ) ,619-24 More Information

Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B (2015. ) Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function.The Journal of biological chemistry, , 290 (17 ) ,10689-702 More Information

Walker, Ryan G; Angerman, Elizabeth B; Kattamuri, Chandramohan; Lee, Yun-Sil; Lee, Se-Jin; Thompson, Thomas B (2015. ) Alternative binding modes identified for growth and differentiation factor-associated serum protein (GASP) family antagonism of myostatin.The Journal of biological chemistry, , 290 (12 ) ,7506-16 More Information

Nolan, Kristof; Kattamuri, Chandramohan; Luedeke, David M; Angerman, Elizabeth B; Rankin, Scott A; Stevens, Mariana L; Zorn, Aaron M; Thompson, Thomas B (2015. ) Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists.The Journal of biological chemistry, , 290 (8 ) ,4759-71 More Information

Peng, Jia; Wigglesworth, Karen; Rangarajan, Adithya; Eppig, John J; Thompson, Thomas B; Matzuk, Martin M (2014. ) Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities.Biology of reproduction, , 91 (6 ) ,142 More Information

Walker, Ryan G; Poggioli, Tommaso; Katsimpardi, Lida; Buchanan, Sean M; Oh, Juhyun; Wattrus, Sam; Heidecker, Bettina; Fong, Yick W; Rubin, Lee L; Ganz, Peter; Thompson, Thomas B; Wagers, Amy J; Lee, Richard T (2016. ) Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.Circulation research, , 118 (7 ) ,1125-42 More Information

Melchior, John T; Walker, Ryan G; Morris, Jamie; Jones, Martin K; Segrest, Jere P; Lima, Diogo B; Carvalho, Paulo C; Gozzo, Fábio C; Castleberry, Mark; Thompson, Thomas B; Davidson, W Sean (2016. ) An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding.The Journal of biological chemistry, , 291 (10 ) ,5439-51 More Information

Poggioli, Tommaso; Vujic, Ana; Yang, Peiguo; Macias-Trevino, Claudio; Uygur, Aysu; Loffredo, Francesco S; Pancoast, James R; Cho, Miook; Goldstein, Jill; Tandias, Rachel M; Gonzalez, Emilia; Walker, Ryan G; Thompson, Thomas B; Wagers, Amy J; Fong, Yick W; Lee, Richard T (2016. ) Circulating Growth Differentiation Factor 11/8 Levels Decline With Age.Circulation research, , 118 (1 ) ,29-37 More Information

Li, Naisi; Yang, Qiyuan; Walker, Ryan G; Thompson, Thomas B; Du, Min; Rodgers, Buel D (2016. ) Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis.Endocrinology, , 157 (1 ) ,282-91 More Information

Yilmaz, Atilgan; Kattamuri, Chandramohan; Ozdeslik, Rana N; Schmiedel, Carolyn; Mentzer, Sarah; Schorl, Christoph; Oancea, Elena; Thompson, Thomas B; Fallon, Justin R (2016. ) MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells.Science signaling, , 9 (444 ) ,ra87 More Information

Nolan, Kristof; Kattamuri, Chandramohan; Rankin, Scott A; Read, Randy J; Zorn, Aaron M; Thompson, Thomas B (2016. ) Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism.Cell reports, , 16 (8 ) ,2077-86 More Information

Sanders, Lehanna N; Schoenhard, John A; Saleh, Mohamed A; Mukherjee, Amrita; Ryzhov, Sergey; McMaster, William G; Nolan, Kristof; Gumina, Richard J; Thompson, Thomas B; Magnuson, Mark A; Harrison, David G; Hatzopoulos, Antonis K (2016. ) BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction.Circulation research, , 119 (3 ) ,434-49 More Information

Bylund, Jeffery B; Trinh, Linh T; Awgulewitsch, Cassandra P; Paik, David T; Jetter, Christopher; Jha, Rajneesh; Zhang, Jianhua; Nolan, Kristof; Xu, Chunhui; Thompson, Thomas B; Kamp, Timothy J; Hatzopoulos, Antonis K (2017. ) Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2.Stem cells and development, , 26 (9 ) ,678-693 More Information

Kattamuri, Chandramohan; Nolan, Kristof; Thompson, Thomas B (2017. ) Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif.The Biochemical journal, , 474 (7 ) ,1093-1107 More Information

Walker, Ryan G; Czepnik, Magdalena; Goebel, Erich J; McCoy, Jason C; Vujic, Ana; Cho, Miook; Oh, Juhyun; Aykul, Senem; Walton, Kelly L; Schang, Gauthier; Bernard, Daniel J; Hinck, Andrew P; Harrison, Craig A; Martinez-Hackert, Erik; Wagers, Amy J; Lee, Richard T; Thompson, Thomas B (2017. ) Structural basis for potency differences between GDF8 and GDF11.BMC biology, , 15 (1 ) ,19 More Information

Cotton, Thomas R; Fischer, Gerhard; Wang, Xuelu; McCoy, Jason C; Czepnik, Magdalena; Thompson, Thomas B; Hyvönen, Marko (2018. ) Structure of the human myostatin precursor and determinants of growth factor latency.The EMBO journal, , 37 (3 ) ,367-383 More Information

Walker, Ryan G; McCoy, Jason C; Czepnik, Magdalena; Mills, Melanie J; Hagg, Adam; Walton, Kelly L; Cotton, Thomas R; Hyvönen, Marko; Lee, Richard T; Gregorevic, Paul; Harrison, Craig A; Thompson, Thomas B (2018. ) Molecular characterization of latent GDF8 reveals mechanisms of activation.Proceedings of the National Academy of Sciences of the United States of America, , 115 (5 ) ,E866-E875 More Information

Melchior, John T; Walker, Ryan G; Cooke, Allison L; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B; Jones, Martin K; Song, Hyun D; Rye, Kerry-Anne; Oda, Michael N; Sorci-Thomas, Mary G; Thomas, Michael J; Heinecke, Jay W; Mei, Xiaohu; Atkinson, David; Segrest, Jere P; Lund-Katz, Sissel; Phillips, Michael C; Davidson, W Sean (2017. ) A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state.Nature structural & molecular biology, , 24 (12 ) ,1093-1099 More Information

Kattamuri, Chandramohan; Nolan, Kristof; Thompson, Thomas B (2017. ) Correction: Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif.The Biochemical journal, , 474 (9 ) ,1529 More Information

Lian, John; Walker, Ryan G; D'Amico, Andrea; Vujic, Ana; Mills, Melanie J; Messemer, Kathleen A; Mendello, Kourtney R; Goldstein, Jill M; Leacock, Krystynne A; Epp, Soraya; Stimpfl, Emma V; Thompson, Thomas B; Wagers, Amy J; Lee, Richard T (2023. ) Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.Life science alliance, , 6 (3 ) , More Information

Gipson, Gregory R; Nolan, Kristof; Kattamuri, Chandramohan; Kenny, Alan P; Agricola, Zachary; Edwards, Nicole A; Zinski, Joseph; Czepnik, Magdalena; Mullins, Mary C; Zorn, Aaron M; Thompson, Thomas B (2023. ) Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.BMC biology, , 21 (1 ) ,16 More Information

Kappes, Emily C; Kattamuri, Chandramohan; Czepnik, Magdalena; Yarawsky, Alexander E; Brûlé, Emilie; Wang, Ying; Ongaro, Luisina; Herr, Andrew B; Walton, Kelly L; Bernard, Daniel J; Thompson, Thomas B (2023. ) Follistatin Forms a Stable Complex With Inhibin A That Does Not Interfere With Activin A Antagonism.Endocrinology, , 164 (3 ) , More Information

Goebel, Erich J; Ongaro, Luisina; Kappes, Emily C; Vestal, Kylie; Belcheva, Elitza; Castonguay, Roselyne; Kumar, Ravindra; Bernard, Daniel J; Thompson, Thomas B (2022. ) The orphan ligand, activin C, signals through activin receptor-like kinase 7.eLife, , 11 , More Information

Howard, James A; Hart, Kaitlin N; Thompson, Thomas B (2022. ) Molecular Mechanisms of AMH Signaling.Frontiers in endocrinology, , 13 ,927824 More Information

Xu, Pauline C; You, Mikyoung; Yu, Seok-Yeong; Luan, Yi; Eldani, Maya; Caffrey, Thomas C; Grandgenett, Paul M; O'Connell, Kelly A; Shukla, Surendra K; Kattamuri, Chandramohan; Hollingsworth, Michael A; Singh, Pankaj K; Thompson, Thomas B; Chung, Soonkyu; Kim, So-Youn (2022. ) Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling.Scientific reports, , 12 (1 ) ,1659 More Information

Goebel, Erich J; Kattamuri, Chandramohan; Gipson, Gregory R; Krishnan, Lavanya; Chavez, Moises; Czepnik, Magdalena; Maguire, Michelle C; Grenha, Rosa; Håkansson, Maria; Logan, Derek T; Grinberg, Asya V; Sako, Dianne; Castonguay, Roselyne; Kumar, Ravindra; Thompson, Thomas B (2022. ) Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors.iScience, , 25 (1 ) ,103590 More Information

Brown, Melissa L; Lopez, Alexa; Meyer, Nolan; Richter, Alden; Thompson, Thomas B (2021. ) FSTL3-Neutralizing Antibodies Enhance Glucose-Responsive Insulin Secretion in Dysfunctional Male Mouse and Human Islets.Endocrinology, , 162 (10 ) , More Information

Hart, Kaitlin N; Stocker, William A; Nagykery, Nicholas G; Walton, Kelly L; Harrison, Craig A; Donahoe, Patricia K; Pépin, David; Thompson, Thomas B (2021. ) Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family.Proceedings of the National Academy of Sciences of the United States of America, , 118 (26 ) , More Information

McCoy, Jason C; Goebel, Erich J; Thompson, Thomas B (2021. ) Characterization of tolloid-mediated cleavage of the GDF8 procomplex.The Biochemical journal, , 478 (9 ) ,1733-1747 More Information

Thompson, T B; Meisl, G; Knowles, T P J; Goriely, A (2021. ) The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.The Journal of chemical physics, , 154 (12 ) ,125101 More Information

Walker, Ryan G; Kattamuri, Chandramohan; Goebel, Erich J; Zhang, Fuming; Hammel, Michal; Tainer, John A; Linhardt, Robert J; Thompson, Thomas B (2021. ) Heparin-mediated dimerization of follistatin.Experimental biology and medicine (Maywood, N.J.), , 246 (4 ) ,467-482 More Information

Gipson, Gregory R; Goebel, Erich J; Hart, Kaitlin N; Kappes, Emily C; Kattamuri, Chandramohan; McCoy, Jason C; Thompson, Thomas B (2020. ) Structural perspective of BMP ligands and signaling.Bone, , 140 ,115549 More Information

Thompson, Travis B; Chaggar, Pavanjit; Kuhl, Ellen; Goriely, Alain (2020. ) Protein-protein interactions in neurodegenerative diseases: A conspiracy theory.PLoS computational biology, , 16 (10 ) ,e1008267 More Information

Gipson, Gregory R; Kattamuri, Chandramohan; Czepnik, Magdalena; Thompson, Thomas B (2020. ) Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST.The Biochemical journal, , 477 (17 ) ,3167-3182 More Information

Hart, Kaitlin N; Pépin, David; Czepnik, Magdalena; Donahoe, Patricia K; Thompson, Thomas B (2020. ) Mutational Analysis of the Putative Anti-Müllerian Hormone (AMH) Binding Interface on its Type II Receptor, AMHR2.Endocrinology, , 161 (7 ) , More Information

Aykul, Senem; Corpina, Richard A; Goebel, Erich J; Cunanan, Camille J; Dimitriou, Alexandra; Kim, Hyon Jong; Zhang, Qian; Rafique, Ashique; Leidich, Raymond; Wang, Xin; McClain, Joyce; Jimenez, Johanna; Nannuru, Kalyan C; Rothman, Nyanza J; Lees-Shepard, John B; Martinez-Hackert, Erik; Murphy, Andrew J; Thompson, Thomas B; Economides, Aris N; Idone, Vincent (2020. ) Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop.eLife, , 9 , More Information

Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean (2020. ) Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH.Journal of lipid research, , 61 (2 ) ,244-251 More Information

Thompson, Thomas B; Kovall, Rhett A (2019. ) Structural biology: Gaining atomic level insight into the biological function of macromolecules.Experimental biology and medicine (Maywood, N.J.), , 244 (17 ) ,1507-1509 More Information

Goebel, Erich J; Hart, Kaitlin N; McCoy, Jason C; Thompson, Thomas B (2019. ) Structural biology of the TGFβ family.Experimental biology and medicine (Maywood, N.J.), , 244 (17 ) ,1530-1546 More Information

Cox, Timothy C; Lidral, Andrew C; McCoy, Jason C; Liu, Huan; Cox, Liza L; Zhu, Ying; Anderson, Ryan D; Moreno Uribe, Lina M; Anand, Deepti; Deng, Mei; Richter, Chika T; Nidey, Nichole L; Standley, Jennifer M; Blue, Elizabeth E; Chong, Jessica X; Smith, Joshua D; Kirk, Edwin P; Venselaar, Hanka; Krahn, Katy N; van Bokhoven, Hans; Zhou, Huiqing; Cornell, Robert A; Glass, Ian A; Bamshad, Michael J; Nickerson, Deborah A; Murray, Jeffrey C; Lachke, Salil A; Thompson, Thomas B; Buckley, Michael F; Roscioli, Tony (2019. ) Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans.Human mutation, , 40 (10 ) ,1813-1825 More Information

Goebel, Erich J; Corpina, Richard A; Hinck, Cynthia S; Czepnik, Magdalena; Castonguay, Roselyne; Grenha, Rosa; Boisvert, Angela; Miklossy, Gabriella; Fullerton, Paul T; Matzuk, Martin M; Idone, Vincent J; Economides, Aris N; Kumar, Ravindra; Hinck, Andrew P; Thompson, Thomas B (2019. ) Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.Proceedings of the National Academy of Sciences of the United States of America, , 116 (31 ) ,15505-15513 More Information

Panmanee, Warunya; Su, Shengchang; Schurr, Michael J; Lau, Gee W; Zhu, Xiaoting; Ren, Zhaowei; McDaniel, Cameron T; Lu, Long J; Ohman, Dennis E; Muruve, Daniel A; Panos, Ralph J; Yu, Hongwei D; Thompson, Thomas B; Tseng, Boo Shan; Hassett, Daniel J (2019. ) The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection.PloS one, , 14 (6 ) ,e0216401 More Information

Czaja, Wioletta; Nakamura, Yukiko K; Li, Naisi; Eldridge, Jennifer A; DeAvila, David M; Thompson, Thomas B; Rodgers, Buel D (2019. ) Myostatin regulates pituitary development and hepatic IGF1.American journal of physiology. Endocrinology and metabolism, , 316 (6 ) ,E1036-E1049 More Information

McCoy, Jason C; Walker, Ryan G; Murray, Nathan H; Thompson, Thomas B (2019. ) Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11.The Journal of biological chemistry, , 294 (16 ) ,6333-6343 More Information

Walker, Ryan G; Thompson, Thomas B (2018. ) New Insight Into Hyperemesis Gravidarum and a Potential Role for GDF15.Endocrinology, , 159 (7 ) ,2698-2700 More Information

Cooke, Allison L; Morris, Jamie; Melchior, John T; Street, Scott E; Jerome, W Gray; Huang, Rong; Herr, Andrew B; Smith, Loren E; Segrest, Jere P; Remaley, Alan T; Shah, Amy S; Thompson, Thomas B; Davidson, W Sean (2018. ) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.Journal of lipid research, , 59 (7 ) ,1244-1255 More Information

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