Nikolai Timchenko

Nikolai Timchenko

Professor-Affiliate

Childrens Hospital Bldg R

COM Surgery Pediatric - 0054

Cincinnati Children's Hospital Medical Center
Division of Pediatric Surgery
Cincinnati, Ohio 45229

Education

Doctoral Degree, Institute of Experimental Medicine, St. Petersburg, Russia

Post-Doctoral Fellowship, Baylor College of Medicine Houston, TX, (Pathology)

Publications

Peer Reviewed Publications

Miller, Nicholas J; Schick, Kaitlyn; Timchenko, Nikolai; Harrison, Emmett; Roesler, William J (2016. ) The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBP?.Journal of cellular biochemistry, , 117 (3 ) ,612-20

Fleet, Tiffany; Zhang, Bin; Lin, Fumin; Zhu, Bokai; Dasgupta, Subhamoy; Stashi, Erin; Tackett, Bryan; Thevananther, Sundararajah; Rajapakshe, Kimal I; Gonzales, Naomi; Dean, Adam; Mao, Jianqiang; Timchenko, Nikolai; Malovannaya, Anna; Qin, Jun; Coarfa, Cristian; DeMayo, Francesco; Dacso, Clifford C; Foulds, Charles E; O'Malley, Bert W; York, Brian (2015. ) SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis.Proceedings of the National Academy of Sciences of the United States of America, , 112 (44 ) ,E6068-77

Breaux, Meghan; Lewis, Kyle; Valanejad, Leila; Iakova, Polina; Chen, Fengju; Mo, Qianxing; Medrano, Estela; Timchenko, Lubov; Timchenko, Nikolai (2015. ) p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways.Molecular and cellular biology, , 35 (17 ) ,3005-16

Timchenko, Nikolai A (2015. ) Cell-type specific functions of epidermal growth factor receptor are involved in development of hepatocellular carcinoma.Hepatology (Baltimore, Md.), , 62 (1 ) ,314-6

Jones, Karlie; Wei, Christina; Schoser, Benedikt; Meola, Giovanni; Timchenko, Nikolai; Timchenko, Lubov (2015. ) Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5.Proceedings of the National Academy of Sciences of the United States of America, , 112 (26 ) ,8041-5

Jin, Jingling; Hong, Il-Hwa; Lewis, Kyle; Iakova, Polina; Breaux, Meghan; Jiang, Yanjun; Sullivan, Emily; Jawanmardi, Nicole; Timchenko, Lubov; Timchenko, Nikolai A (2015. ) Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration.Hepatology (Baltimore, Md.), , 61 (1 ) ,315-25

Hong, Il-Hwa; Lewis, Kyle; Iakova, Polina; Jin, Jingling; Sullivan, Emily; Jawanmardi, Nicole; Timchenko, Lubov; Timchenko, Nikolai (2014. ) Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments.The Journal of biological chemistry, , 289 (2 ) ,1106-18

Jiang, Yanjun; Jin, Jingling; Iakova, Polina; Hernandez, Julio Cesar; Jawanmardi, Nicole; Sullivan, Emily; Guo, Grace L; Timchenko, Nikolai A; Darlington, Gretchen J (2013. ) Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice.Mechanisms of ageing and development, , 134 (9 ) ,407-15

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Lewis, Kyle; Sullivan, Emily; Jawanmardi, Nicole; Donehower, Lawrence; Timchenko, Lubov; Timchenko, Nikolai A (2013. ) Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1? proteins at the early and late stages of liver cancer.The Journal of biological chemistry, , 288 (20 ) ,14451-62

Jin, Jingling; Iakova, Polina; Breaux, Meghan; Sullivan, Emily; Jawanmardi, Nicole; Chen, Dahu; Jiang, Yanjun; Medrano, Estela M; Timchenko, Nikolai A (2013. ) Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis.Cell reports, , 3 (3 ) ,831-43

Jiang, Yanjun; Iakova, Polina; Jin, Jingling; Sullivan, Emily; Sharin, Vladislav; Hong, Il-Hwa; Anakk, Sayee; Mayor, Angela; Darlington, Gretchen; Finegold, Milton; Moore, David; Timchenko, Nikolai A (2013. ) Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.Hepatology (Baltimore, Md.), , 57 (3 ) ,1098-106

Wei, Christina; Jones, Karlie; Timchenko, Nikolai A; Timchenko, Lubov (2013. ) GSK3? is a new therapeutic target for myotonic dystrophy type 1.Rare diseases (Austin, Tex.), , 1 ,e26555

Jones, Karlie; Wei, Christina; Iakova, Polina; Bugiardini, Enrico; Schneider-Gold, Christiane; Meola, Giovanni; Woodgett, James; Killian, James; Timchenko, Nikolai A; Timchenko, Lubov T (2012. ) GSK3? mediates muscle pathology in myotonic dystrophy.The Journal of clinical investigation, , 122 (12 ) ,4461-72

Jones, Karlie; Timchenko, Lubov; Timchenko, Nikolai A (2012. ) The role of CUGBP1 in age-dependent changes of liver functions.Ageing research reviews, , 11 (4 ) ,442-9

Jones, Karlie; Jin, Bingwen; Iakova, Polina; Huichalaf, Claudia; Sarkar, Partha; Schneider-Gold, Christiane; Schoser, Benedikt; Meola, Giovanni; Shyu, Ann-Bin; Timchenko, Nikolai; Timchenko, Lubov (2011. ) RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2.The American journal of pathology, , 179 (5 ) ,2475-89

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Medrano, Estela E; Timchenko, Nikolai A (2011. ) The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation.Hepatology (Baltimore, Md.), , 54 (3 ) ,989-98

Haefliger, Simon; Klebig, Christiane; Schaubitzer, Kerstin; Schardt, Julian; Timchenko, Nikolai; Mueller, Beatrice U; Pabst, Thomas (2011. ) Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML.Blood, , 117 (22 ) ,5931-40

Iakova, Polina; Timchenko, Lubov; Timchenko, Nikolai A (2011. ) Intracellular signaling and hepatocellular carcinoma.Seminars in cancer biology, , 21 (1 ) ,28-34

Jin, Jingling; Wang, Guo-Li; Iakova, Polina; Shi, Xiurong; Haefliger, Simon; Finegold, Milton; Timchenko, Nikolai A (2010. ) Epigenetic changes play critical role in age-associated dysfunctions of the liver.Aging cell, , 9 (5 ) ,895-910

Huichalaf, Claudia; Sakai, Keiko; Jin, Bingwen; Jones, Karlie; Wang, Guo-Li; Schoser, Benedikt; Schneider-Gold, Christiane; Sarkar, Partha; Pereira-Smith, Olivia M; Timchenko, Nikolai; Timchenko, Lubov (2010. ) Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 24 (10 ) ,3706-19

Orellana, Daniel; Liu, Xiaoying; Wang, Gou-Li; Jin, Jingling; Iakova, Polina; Timchenko, Nikolai A (2010. ) Calmodulin controls liver proliferation via interactions with C/EBPbeta-LAP and C/EBPbeta-LIP.The Journal of biological chemistry, , 285 (30 ) ,23444-56

Wang, Guo-Li; Shi, Xiurong; Haefliger, Simon; Jin, Jingling; Major, Angela; Iakova, Polina; Finegold, Milton; Timchenko, Nikolai A (2010. ) Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice.The Journal of clinical investigation, , 120 (7 ) ,2549-62

Schardt, Julian A; Eyholzer, Marianne; Timchenko, Nikolai A; Mueller, Beatrice U; Pabst, Thomas (2010. ) Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia.Journal of cellular and molecular medicine, , 14 (6B ) ,1509-19

Lin, Qiushi; Chen, Dahu; Timchenko, Nikolai A; Medrano, Estela E (2010. ) SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta. Cell cycle (Georgetown, Tex.), , 9 (9 ) ,1684-9

Willis-Martinez, Danielle; Richards, Hunter W; Timchenko, Nikolai A; Medrano, Estela E (2010. ) Role of HDAC1 in senescence, aging, and cancer.Experimental gerontology, , 45 (4 ) ,279-85

Chen, Dahu; Lin, Qiushi; Box, Neil; Roop, Dennis; Ishii, Shunsuke; Matsuzaki, Koichi; Fan, Tao; Hornyak, Thomas J; Reed, Jon A; Stavnezer, Ed; Timchenko, Nikolai A; Medrano, Estela E (2009. ) SKI knockdown inhibits human melanoma tumor growth in vivo.Pigment cell & melanoma research, , 22 (6 ) ,761-72

Salisbury, Elizabeth; Schoser, Benedikt; Schneider-Gold, Christiane; Wang, Guo-Li; Huichalaf, Claudia; Jin, Bingwen; Sirito, Mario; Sarkar, Partha; Krahe, Ralf; Timchenko, Nikolai A; Timchenko, Lubov T (2009. ) Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients.The American journal of pathology, , 175 (2 ) ,748-62

Jin, Jingling; Wang, Guo-Li; Salisbury, Elizabeth; Timchenko, Lubov; Timchenko, Nikolai A (2009. ) GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy. Cell cycle (Georgetown, Tex.), , 8 (15 ) ,2356-9

Jin, Jingling; Wang, Guo-Li; Shi, Xiurong; Darlington, Gretchen J; Timchenko, Nikolai A (2009. ) The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration.Molecular and cellular biology, , 29 (14 ) ,3867-80

Jin, Jingling; Wang, Guo-Li; Timchenko, Lubov; Timchenko, Nikolai A (2009. ) GSK3beta and aging liver. Aging, , 1 (6 ) ,582-5

Timchenko, Nikolai A (2009. ) Aging and liver regeneration.Trends in endocrinology and metabolism: TEM, , 20 (4 ) ,171-6

Wang, Guo-Li; Salisbury, Elizabeth; Shi, Xiurong; Timchenko, Lubov; Medrano, Estela E; Timchenko, Nikolai A (2008. ) HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice.The Journal of biological chemistry, , 283 (38 ) ,26169-78

Wang, Guo-Li; Salisbury, Elizabeth; Shi, Xiurong; Timchenko, Lubov; Medrano, Estela E; Timchenko, Nikolai A (2008. ) HDAC1 promotes liver proliferation in young mice via interactions with C/EBPbeta.The Journal of biological chemistry, , 283 (38 ) ,26179-87

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Timchenko, Nikolai A (2008. ) Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines.Experimental cell research, , 314 (7 ) ,1626-39

Harrison-Findik, Duygu Dee; Klein, Elizabeth; Crist, Callie; Evans, John; Timchenko, Nikolai; Gollan, John (2007. ) Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol.Hepatology (Baltimore, Md.), , 46 (6 ) ,1979-85

Smith, Roy G; Sun, Yuxiang; Jiang, Hong; Albarran-Zeckler, Rosie; Timchenko, Nikolai (2007. ) Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.Annals of the New York Academy of Sciences, , 1119 ,147-64

Choi, William T; Folsom, Matthew R; Azim, Mohammed F; Meyer, Claus; Kowarz, Eric; Marschalek, Rolf; Timchenko, Nikolai A; Naeem, Rizwan C; Lee, Dean A (2007. ) C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL.Cancer genetics and cytogenetics, , 177 (2 ) ,108-14

Bandyopadhyay, Debdutta; Curry, Jonathan L; Lin, Qiushi; Richards, Hunter W; Chen, Dahu; Hornsby, Peter J; Timchenko, Nikolai A; Medrano, Estela E (2007. ) Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.Aging cell, , 6 (4 ) ,577-91

Huichalaf, Claudia H; Sakai, Keiko; Wang, Guo-Li; Timchenko, Nikolai A; Timchenko, Lubov (2007. ) Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis.Gene, , 396 (2 ) ,391-402

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Sun, Yuxiang; Albrecht, Jeffrey H; Smith, Roy G; Timchenko, Nikolai A (2007. ) Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex.The Journal of biological chemistry, , 282 (2 ) ,1468-78

Timchenko, Lubov T; Salisbury, Elizabeth; Wang, Guo-Li; Nguyen, Heather; Albrecht, Jeffrey H; Hershey, John W B; Timchenko, Nikolai A (2006. ) Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.The Journal of biological chemistry, , 281 (43 ) ,32806-19

Lee, Young-Jin; Jones, Letetia C; Timchenko, Nikolai A; Perrotti, Danilo; Tenen, Daniel G; Kogan, Scott C (2006. ) CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.Blood, , 108 (7 ) ,2416-9

Karagiannides, Iordanes; Thomou, Thomas; Tchkonia, Tamara; Pirtskhalava, Tamar; Kypreos, Kyriakos E; Cartwright, Andrew; Dalagiorgou, Georgia; Lash, Timothy L; Farmer, Stephen R; Timchenko, Nikolai A; Kirkland, James L (2006. ) Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging.The Journal of biological chemistry, , 281 (32 ) ,23025-33

Harrison-Findik, Duygu Dee; Schafer, Denise; Klein, Elizabeth; Timchenko, Nikolai A; Kulaksiz, Hasan; Clemens, Dahn; Fein, Evelyn; Andriopoulos, Billy; Pantopoulos, Kostas; Gollan, John (2006. ) Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.The Journal of biological chemistry, , 281 (32 ) ,22974-82

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Sun, Yuxiang; Albrecht, Jeffrey H; Smith, Roy G; Timchenko, Nikolai A (2006. ) Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes.Molecular and cellular biology, , 26 (7 ) ,2570-82

Helbling, Daniel; Mueller, Beatrice U; Timchenko, Nikolai A; Schardt, Julian; Eyer, Myriam; Betts, David R; Jotterand, Martine; Meyer-Monard, Sandrine; Fey, Martin F; Pabst, Thomas (2005. ) CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16).Blood, , 106 (4 ) ,1369-75

Schwahn, Denise J; Timchenko, Nikolai A; Shibahara, Shigeki; Medrano, Estela E (2005. ) Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes.Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 18 (3 ) ,203-13

Timchenko, Nikolai A; Wang, Gou-Li; Timchenko, Lubov T (2005. ) RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2.The Journal of biological chemistry, , 280 (21 ) ,20549-57

Bales, Elise; Mills, Lisa; Milam, Nancy; McGahren-Murray, Mollianne; Bandyopadhyay, Debdutta; Chen, Dahu; Reed, Jon A; Timchenko, Nikolai; van den Oord, Joost J; Bar-Eli, Menashe; Keyomarsi, Khandan; Medrano, Estela E (2005. ) The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo. Cancer research, , 65 (3 ) ,692-7

Wang, Guo-Li; Timchenko, Nikolai A (2005. ) Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein.Molecular and cellular biology, , 25 (4 ) ,1325-38

Helbling, Daniel; Mueller, Beatrice U; Timchenko, Nikolai A; Hagemeijer, Anne; Jotterand, Martine; Meyer-Monard, Sandrine; Lister, Andrew; Rowley, Janet D; Huegli, Barbara; Fey, Martin F; Pabst, Thomas (2004. ) The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin.Proceedings of the National Academy of Sciences of the United States of America, , 101 (36 ) ,13312-7

Baldwin, Brenda R; Timchenko, Nikolai A; Zahnow, Cynthia A (2004. ) Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells. Molecular and cellular biology, , 24 (9 ) ,3682-91

Wang, Guo-Li; Iakova, Polina; Wilde, Margie; Awad, Samir; Timchenko, Nikolai A (2004. ) Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.Genes & development, , 18 (8 ) ,912-25

Timchenko, Nikolai A; Patel, Roma; Iakova, Polina; Cai, Zong-Jin; Quan, Ling; Timchenko, Lubov T (2004. ) Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis.The Journal of biological chemistry, , 279 (13 ) ,13129-39

Iakova, Polina; Wang, Guo-Li; Timchenko, Lubov; Michalak, Marek; Pereira-Smith, Olivia M; Smith, James R; Timchenko, Nikolai A (2004. ) Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.The EMBO journal, , 23 (2 ) ,406-17

Yan, Yan; Phan, Leuyen; Yang, Fan; Talpaz, Moshe; Yang, Yu; Xiong, Zeyu; Ng, Bernard; Timchenko, Nikolai A; Wu, Catherine J; Ritz, Jerome; Wang, Hong; Yang, Xiao-Feng (2004. ) A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. Journal of immunology (Baltimore, Md. : 1950), , 172 (1 ) ,651-60

Timchenko, Nikolai A Old livers--C/EBPalpha meets new partners. Cell cycle (Georgetown, Tex.), , 2 (5 ) ,445-6

Iakova, Polina; Awad, Samir S; Timchenko, Nikolai A (2003. ) Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell, , 113 (4 ) ,495-506

Timchenko, Lubov T; Iakova, Polina; Welm, Alana L; Cai, Z-J; Timchenko, Nikolai A (2002. ) Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins. Molecular and cellular biology, , 22 (20 ) ,7242-57

Welm, Alana L; Timchenko, Nikolai A; Ono, Yasuko; Sorimachi, Hiroyuki; Radomska, Hannah S; Tenen, Daniel G; Lekstrom-Himes, Julie; Darlington, Gretchen J (2002. ) C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells.The Journal of biological chemistry, , 277 (37 ) ,33848-56

Rickheim, David G; Nelsen, Christopher J; Fassett, John T; Timchenko, Nikolai A; Hansen, Linda K; Albrecht, Jeffrey H (2002. ) Differential regulation of cyclins D1 and D3 in hepatocyte proliferation.Hepatology (Baltimore, Md.), , 36 (1 ) ,30-8

Wang, Hongmei; Goode, Triona; Iakova, Polina; Albrecht, Jeffrey H; Timchenko, Nikolai A (2002. ) C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest.The EMBO journal, , 21 (5 ) ,930-41

Lewis, Kyle; Valanejad, Leila; Cast, Ashley; Wright, Mary; Wei, Christina; Iakova, Polina; Stock, Lauren; Karns, Rebekah; Timchenko, Lubov; Timchenko, Nikolai (2017. ) RNA binding protein CUGBP1 inhibits liver cancer in a phosphorylation dependent manner.Molecular and cellular biology, ,

Valanejad, Leila; Lewis, Kyle; Wright, Mary; Jiang, Yanjun; D'Souza, Amber; Karns, Rebekah; Sheridan, Rachel; Gupta, Anita; Bove, Kevin; Witte, David; Geller, James; Tiao, Gregory; Nelson, David L; Timchenko, Lubov; Timchenko, Nikolai (2017. ) FXR-Gankyrin axis is involved in development of pediatric liver cancer.Carcinogenesis, ,

Tiao, Gregory; Geller, James; Timchenko, Nikolai A (2016. ) Generation of pediatric liver cancer patient-derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments.Hepatology (Baltimore, Md.), , 64 (4 ) ,1017-9

Jin, Jingling; Valanejad, Leila; Nguyen, Thuy Phuong; Lewis, Kyle; Wright, Mary; Cast, Ashley; Stock, Lauren; Timchenko, Lubov; Timchenko, Nikolai A (2016. ) Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.Cell reports, , 16 (3 ) ,744-56

Valanejad, Leila; Timchenko, Nikolai (2016. ) Akt-FoxO1 axis controls liver regeneration.Hepatology (Baltimore, Md.), , 63 (5 ) ,1424-6

Khanal T.;Leung Y.K.;Jiang W.;Timchenko N.;Ho S.M.;Kim K. (07-01-2019. ) NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver in.FASEB Journal, , 33 (7 ) ,8335-8348

Wang M.;Weng W.C.;Stock L.;Lindquist D.;Martinez A.;Gourdon G.;Timchenko N.;Snape M.;Timchenkoa L. (01-01-2019. ) Correction of glycogen synthase kinase 3? in myotonic dystrophy 1 reduces the mutant RNA and improve.Molecular and Cellular Biology, , 39 (21 ) ,

Valanejad L.;Cast A.;Wright M.;Bissig K.;Karns R.;Weirauch M.;Timchenko N. (12-01-2018. ) PARP1 activation increases expression of modified tumor suppressors and pathways underlying developm.Communications Biology, , 1 (1 ) ,

Nguyen P.;Valanejad L.;Cast A.;Wright M.;Garcia J.;El-Serag H.;Karns R.;Timchenko N. (08-07-2018. ) Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of c.Cell Reports, , 24 (6 ) ,1597-1609

Rodriguez K.;Cast A.;Timchenko N. (08-01-2018. ) Correction of aging phenotype in the liver.Aging, , 10 (8 ) ,1795-1796

Wei C.;Stock L.;Schneider-Gold C.;Sommer C.;Timchenko N.A.;Timchenko L. (07-01-2018. ) Reduction of cellular nucleic acid binding protein encoded by a myotonic dystrophy type 2 gene cause.Molecular and Cellular Biology, , 38 (14 ) ,

Cast A.;Valanejad L.;Wright M.;Nguyen P.;Gupta A.;Zhu L.;Shin S.;Timchenko N. (05-01-2018. ) C/EBP?-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive .Hepatology, , 67 (5 ) ,1857-1871

Wei C.;Stock L.;Valanejad L.;Zalewski Z.;Karns R.;Puymirat J.;Nelson D.;Witte D.;Woodgett J.;Timchenko N.;Timchenko L. (04-01-2018. ) Correction of GSK3? at young age prevents muscle pathology in mice with myotonic dystrophy type 1.FASEB Journal, , 32 (4 ) ,2073-2085

Timchenko N. (03-01-2018. ) Mitochondrial and anabolic pathways in hepatocellular carcinoma.Hepatology, , 67 (3 ) ,823-825

Guillory B.;Jawanmardi N.;Iakova P.;Anderson B.;Zang P.;Timchenko N.;Garcia J. (02-01-2018. ) Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBP?-p300.Aging Cell, , 17 (1 ) ,

D'Souza A.;Jiang Y.;Cast A.;Valanejad L.;Wright M.;Lewis K.;Kumbaji M.;Shah S.;Smithrud D.;Karns R.;Shin S.;Timchenko N. (01-01-2018. ) Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.Cellular and Molecular Gastroenterology and Hepatology, , 6 (3 ) ,239-255

He Q.;Wang F.;Honda T.;Lindquist D.;Dillman J.;Timchenko N.;Redington A. (10-01-2017. ) Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in .Tumor Biology, , 39 (10 ) ,1-8

Lin Q.;Chen D.;Timchenko N.;Medrano E. (05-01-2010. ) SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGF?.Cell Cycle, , 9 (9 ) ,1684-1689

McFie P.;Wang G.;Timchenko N.;Wilson H.;Hu X.;Roesler W. (06-30-2006. ) Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of C.Journal of Biological Chemistry, , 281 (26 ) ,18069-18080

Rickheim D.;Nelsen C.;Fassett J.;Timchenko N.;Hansen L.;Albrecht J. (01-01-2002. ) Differential regulation of cyclins D1 and D3 in hepatocyte proliferation.Hepatology, , 36 (1 ) ,30-38

Nelsen C.;Rickheim D.;Timchenko N.;Stanley M.;Albrecht J. (12-01-2001. ) Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth i .Cancer Research, , 61 (23 ) ,8564-8568

Leung J.;Berube N.;Venable S.;Ahmed S.;Timchenko N.;Pereira-Smith O. (10-19-2001. ) MRG15 Activates the B-myb Promoter through Formation of a Nuclear Complex with the Retinoblastoma Pr.Journal of Biological Chemistry, , 276 (42 ) ,39171-39178

Timchenko N.;Iakova P.;Cai Z.;Smith J.;Timchenko L. (10-10-2001. ) Molecular basis for impaired muscle differentiation in myotonic dystrophy.Molecular and Cellular Biology, , 21 (20 ) ,6927-6938

Bandyopadhyay D.;Timchenko N.;Suwa T.;Hornsby P.;Campisi J.;Medrano E. (08-15-2001. ) The human melanocyte: A model system to study the complexity of cellular aging and transformation in.Experimental Gerontology, , 36 (8 ) ,1265-1275

Timchenko N.;Cai Z.;Welm A.;Reddy S.;Ashizawa T.;Timchenko L. (03-16-2001. ) RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1.Journal of Biological Chemistry, , 276 (11 ) ,7820-7826

Wang H.;Iakova P.;Wilde M.;Welm A.;Goode T.;Roesler W.;Timchenko N. (01-01-2001. ) C/EBP? arrests cell proliferation through direct inhibition of Cdk2 and Cdk4.Molecular Cell, , 8 (4 ) ,817-828

Welm A.;Mackey S.;Timchenko L.;Darlington G.;Timchenko N. (09-01-2000. ) Translational induction of liver-enriched transcriptional inhibitory protein during acute phase resp.Journal of Biological Chemistry, , 275 (35 ) ,27406-27413

Timchenko N.;Welm A.;Lu X.;Timchenko L. (11-15-1999. ) CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBP? mRNA and regulates transl.Nucleic Acids Research, , 27 (22 ) ,4517-4525

Timchenko N.;Wilde M.;Iakova P.;Albrecht J.;Darlington G. (09-01-1999. ) E2F/p107 and E2F/p130 complexes are regulated by C/EBP? in 3T3-L1 adipocytes.Nucleic Acids Research, , 27 (17 ) ,3621-3630

Timchenko N.A.;Wilde M.;Darlington G.J. (04-01-1999. ) C/EBP? regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice .Molecular and Cellular Biology, , 19 (4 ) ,2936-2945

Welm A.L.;Timchenko N.A.;Darlington G.J. (03-01-1999. ) C/EBP? regulates generation of C/EBP? isoforms through activation of specific proteolytic cleavage .Molecular and Cellular Biology, , 19 (3 ) ,1695-1704

Burgess-Beusse B.;Timchenko N.;Darlington G. (02-28-1999. ) CCAAT/enhancer binding protein ? (C/EBP? is an important mediator of mouse C/EBP? protein isoform pr.Hepatology, , 29 (2 ) ,597-601

Lu X.;Timchenko N.;Timchenko L. (01-26-1999. ) Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystroph.Human Molecular Genetics, , 8 (1 ) ,53-60

Timchenko N.;Wilde M.;Kosai K.;Heydari A.;Bilyeu T.;Finegold M.;Mohamedali K.;Richardson A.;Darlington G. (07-01-1998. ) Regenerating livers of old rats contain high levels of C/EBP? that correlate with altered expression.Nucleic Acids Research, , 26 (13 ) ,3293-3299

Timchenko N.A.;Harris T.E.;Wilde M.;Bilyeu T.A.;Burgess-Beusse B.L.;Finegold M.J.;Darlington G.J. (12-01-1997. ) CCAAT/enhancer binding protein ? regulates p21 protein and hepatocyte proliferation in newborn mice .Molecular and Cellular Biology, , 17 (12 ) ,7353-7361

Roberts R.;Timchenko N.;Miller J.;Reddy S.;Caskey C.;Swanson M.;Timchenko L. (11-25-1997. ) Altered phosphorylation and intracellular distribution of a (CUG)n triplet re.Proceedings of the National Academy of Sciences of the United States of America, , 94 (24 ) ,13221-13226

Timchenko L.;Miller J.;Timchenko N.;Devore D.;Datar K.;Lin L.;Roberts R.;Thomas Caskey C.;Swanson M. (11-30-1996. ) Identification of a (CUG)(n) triplet repeat RNA-binding protein and its expression in myotonic dystr.Nucleic Acids Research, , 24 (22 ) ,4407-4414

Timchenko N.;Wilde M.;Nakanishi M.;Smith J.;Darlington G. (04-01-1996. ) CCAAT/enhancer-binding protein ? (C/EBP?) inhibits cell proliferation through the p21 (WAF-1/CIP-1/S.Genes and Development, , 10 (7 ) ,804-815

Timchenko L.;Timchenko N.;Caskey C.;Roberts R. (01-01-1996. ) Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: Implications for my.Human Molecular Genetics, , 5 (1 ) ,115-121

Timchenko N.;Wilson D.R.;Taylor L.R.;Abdelsayed S.;Wilde M.;Sawadogo M.;Darlington G.J. (01-01-1995. ) Autoregulation of the human C/EBP? gene by stimulation of upstream stimulatory factor binding .Molecular and Cellular Biology, , 15 (3 ) ,1192-1202

Duniak V.;Timchenko N. (07-01-1994. ) DNA fragment DARC146 from a complex form of DNA polymerase alpha contains several nuclear protein bi .Molekulyarnaya Biologiya, , 28 (4 ) ,822-831

Timchenko N.;Luniak V.;Duniak A. (07-01-1994. ) Segments initiating replication of the dihydrofolate reductase domain and the DNA fragment DARC146 i .Molekulyarnaya Biologiya, , 28 (4 ) ,865-874

Luniak V.;Filatov M.;Ibatullin F.;Timchenko N. (01-01-1993. ) The interaction of nuclear proteins with bent DNA located in an autonomously replicating DARC146 seq .Tsitologiya, , 35 (5 ) ,84-90

Timchenko N.;Zhuchenko O.;Timchenko L.;Iguchi-Ariga S.;Ariga H.;Bozhkov V.;Tomilin N. (01-01-1991. ) Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver int .Biomedical science, , 2 (6 ) ,595-600

Zhuchenko O.;Timchenko L.;Timchenko N. (06-22-1990. ) Increased expression of genes coding for replication proteins in the DNA synthesis period .Molekulyarnaya Biologiya, , 24 (3 ) ,824-831

Timchenko N.;Shcherbakov O.;Krutyakov V.;Filatov M. (06-22-1990. ) Autonomous replication of plasmids bearing DNA fragments from rat liver ?-polymerase complex .Molekulyarnaya Biologiya, , 24 (3 ) ,814-823

Timchenko N.;Belyakova N.;Timchenko L.;Krutyakov V. (01-01-1989. ) Characterization of DNA isolated from a complex form of DNA polymerase ? from rat liver .Molekulyarnaya Biologiya, , 23 (4 ) ,1171-1176

Timchenko L.;Timchenko N.;Giliano N.;Noskin L. (01-01-1988. ) Increased expression of some genes in rat liver after whole-body X-irradiation .Radiobiologiya, , 28 (2 ) ,166-171

Timchenko N.;Shevelev I.;Drobchenko S.;Zhuchenko O.;Krutjakov V. (01-01-1988. ) Isolation and characterization of endonuclease tightly bound with rat liver DNA polymerase ? .Molekulyarnaya Biologiya, , 22 (4 ) ,976-983

Baranov V.;Schwartzman A.;Gorbunova V.;Gaitskhoki V.;Rubtsov N.;Timchenko N.;Neifakh S. (12-01-1987. ) Chromosomal localization of ceruoplasmin and transferrin genes in laboratory rats, mice and in man b.Chromosoma, , 96 (1 ) ,60-66

Timchenko N.;Timchenko L.;Bilobrov S.;Zhuchenko O.;Krutiakov V. (05-01-1987. ) Identification and characteristics of mRNA's showing increased levels during DNA replication .Molekulyarnaya Biologiya, , 21 (3 ) ,640-646

Timchenko N.;Timchenko L.;Krutiakov V. (12-01-1986. ) Cloning of mRNA nucleotide sequences amplified during DNA replication in the regenerating liver .Molekuliarnaia genetika, mikrobiologiia i virusologiia, , (12 ) ,23-25

Salikhov T.;Timchenko L.;Timchenko N. (11-01-1984. ) Isolation and properties of transferrin messenger RNA from rat liver.Chemistry of Natural Compounds, , 20 (6 ) ,723-729

Ryskov A.;Timchenko N.;Timchenko L. (01-01-1984. ) Cloning of double-stranded DNA transcribed from rat transferrin messenger RNA .Molekulyarnaya Biologiya, , 18 (1 ) ,104-114

Timchenko N.;Timchenko L.;Schwartzman A. (01-01-1983. ) Physicochemical and functional characteristics of transferrin messenger RNA from rat liver .Molekulyarnaya Biologiya, , 17 (2 ) ,322-329

Gaitskhoki V.;Timchenko N.;Timchenko L. (01-01-1982. ) Biosynthesis and post-translational maturation of transferrin in subcellular fractions of rat liver .Biokhimiya, , 47 (1 ) ,13-18

Ga?tskhoki V.;Timchenko N.;Timchenko L.;Puchkova L.;Aslanov K. (08-01-1981. ) Properties of rat liver polyribosomes synthesizing transferrin .Biokhimiya, , 46 (8 ) ,1426-1434

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
Division of Pediatric Surgery
CincinnatiĀ  Ohio, 45229
Phone: 513-636-0129
nikolai.timchenko@cchmc.org