Nikolai Timchenko, MD

Doctoral Degree: Institute of Experimental Medicine, St. Petersburg, Russia

Post-Doctoral Fellowship: Baylor College of Medicine Houston, TX, (Pathology)

Peer Reviewed Publications

Miller, Nicholas J; Schick, Kaitlyn; Timchenko, Nikolai; Harrison, Emmett; Roesler, William J  (2016). The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBP?. Journal of cellular biochemistry, 117 (3) , 612-20More Information

Fleet, Tiffany; Zhang, Bin; Lin, Fumin; Zhu, Bokai; Dasgupta, Subhamoy; Stashi, Erin; Tackett, Bryan; Thevananther, Sundararajah; Rajapakshe, Kimal I; Gonzales, Naomi; Dean, Adam; Mao, Jianqiang; Timchenko, Nikolai; Malovannaya, Anna; Qin, Jun; Coarfa, Cristian; DeMayo, Francesco; Dacso, Clifford C; Foulds, Charles E; O'Malley, Bert W; York, Brian  (2015). SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 112 (44) , E6068-77More Information

Breaux, Meghan; Lewis, Kyle; Valanejad, Leila; Iakova, Polina; Chen, Fengju; Mo, Qianxing; Medrano, Estela; Timchenko, Lubov; Timchenko, Nikolai  (2015). p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways. Molecular and cellular biology, 35 (17) , 3005-16More Information

Timchenko, Nikolai A  (2015). Cell-type specific functions of epidermal growth factor receptor are involved in development of hepatocellular carcinoma. Hepatology (Baltimore, Md.), 62 (1) , 314-6More Information

Jones, Karlie; Wei, Christina; Schoser, Benedikt; Meola, Giovanni; Timchenko, Nikolai; Timchenko, Lubov  (2015). Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5. Proceedings of the National Academy of Sciences of the United States of America, 112 (26) , 8041-5More Information

Jin, Jingling; Hong, Il-Hwa; Lewis, Kyle; Iakova, Polina; Breaux, Meghan; Jiang, Yanjun; Sullivan, Emily; Jawanmardi, Nicole; Timchenko, Lubov; Timchenko, Nikolai A  (2015). Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration. Hepatology (Baltimore, Md.), 61 (1) , 315-25More Information

Hong, Il-Hwa; Lewis, Kyle; Iakova, Polina; Jin, Jingling; Sullivan, Emily; Jawanmardi, Nicole; Timchenko, Lubov; Timchenko, Nikolai  (2014). Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments. The Journal of biological chemistry, 289 (2) , 1106-18More Information

Jiang, Yanjun; Jin, Jingling; Iakova, Polina; Hernandez, Julio Cesar; Jawanmardi, Nicole; Sullivan, Emily; Guo, Grace L; Timchenko, Nikolai A; Darlington, Gretchen J  (2013). Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mechanisms of ageing and development, 134 (9) , 407-15More Information

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Lewis, Kyle; Sullivan, Emily; Jawanmardi, Nicole; Donehower, Lawrence; Timchenko, Lubov; Timchenko, Nikolai A  (2013). Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1? proteins at the early and late stages of liver cancer. The Journal of biological chemistry, 288 (20) , 14451-62More Information

Jin, Jingling; Iakova, Polina; Breaux, Meghan; Sullivan, Emily; Jawanmardi, Nicole; Chen, Dahu; Jiang, Yanjun; Medrano, Estela M; Timchenko, Nikolai A  (2013). Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis. Cell reports, 3 (3) , 831-43More Information

Jiang, Yanjun; Iakova, Polina; Jin, Jingling; Sullivan, Emily; Sharin, Vladislav; Hong, Il-Hwa; Anakk, Sayee; Mayor, Angela; Darlington, Gretchen; Finegold, Milton; Moore, David; Timchenko, Nikolai A  (2013). Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology (Baltimore, Md.), 57 (3) , 1098-106More Information

Wei, Christina; Jones, Karlie; Timchenko, Nikolai A; Timchenko, Lubov  (2013). GSK3? is a new therapeutic target for myotonic dystrophy type 1. Rare diseases (Austin, Tex.), 1, e26555More Information

Jones, Karlie; Wei, Christina; Iakova, Polina; Bugiardini, Enrico; Schneider-Gold, Christiane; Meola, Giovanni; Woodgett, James; Killian, James; Timchenko, Nikolai A; Timchenko, Lubov T  (2012). GSK3? mediates muscle pathology in myotonic dystrophy. The Journal of clinical investigation, 122 (12) , 4461-72More Information

Jones, Karlie; Timchenko, Lubov; Timchenko, Nikolai A  (2012). The role of CUGBP1 in age-dependent changes of liver functions. Ageing research reviews, 11 (4) , 442-9More Information

Jones, Karlie; Jin, Bingwen; Iakova, Polina; Huichalaf, Claudia; Sarkar, Partha; Schneider-Gold, Christiane; Schoser, Benedikt; Meola, Giovanni; Shyu, Ann-Bin; Timchenko, Nikolai; Timchenko, Lubov  (2011). RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2. The American journal of pathology, 179 (5) , 2475-89More Information

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Medrano, Estela E; Timchenko, Nikolai A  (2011). The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology (Baltimore, Md.), 54 (3) , 989-98More Information

Haefliger, Simon; Klebig, Christiane; Schaubitzer, Kerstin; Schardt, Julian; Timchenko, Nikolai; Mueller, Beatrice U; Pabst, Thomas  (2011). Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML. Blood, 117 (22) , 5931-40More Information

Iakova, Polina; Timchenko, Lubov; Timchenko, Nikolai A  (2011). Intracellular signaling and hepatocellular carcinoma. Seminars in cancer biology, 21 (1) , 28-34More Information

Jin, Jingling; Wang, Guo-Li; Iakova, Polina; Shi, Xiurong; Haefliger, Simon; Finegold, Milton; Timchenko, Nikolai A  (2010). Epigenetic changes play critical role in age-associated dysfunctions of the liver. Aging cell, 9 (5) , 895-910More Information

Huichalaf, Claudia; Sakai, Keiko; Jin, Bingwen; Jones, Karlie; Wang, Guo-Li; Schoser, Benedikt; Schneider-Gold, Christiane; Sarkar, Partha; Pereira-Smith, Olivia M; Timchenko, Nikolai; Timchenko, Lubov  (2010). Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 (10) , 3706-19More Information

Orellana, Daniel; Liu, Xiaoying; Wang, Gou-Li; Jin, Jingling; Iakova, Polina; Timchenko, Nikolai A  (2010). Calmodulin controls liver proliferation via interactions with C/EBPbeta-LAP and C/EBPbeta-LIP. The Journal of biological chemistry, 285 (30) , 23444-56More Information

Wang, Guo-Li; Shi, Xiurong; Haefliger, Simon; Jin, Jingling; Major, Angela; Iakova, Polina; Finegold, Milton; Timchenko, Nikolai A  (2010). Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. The Journal of clinical investigation, 120 (7) , 2549-62More Information

Schardt, Julian A; Eyholzer, Marianne; Timchenko, Nikolai A; Mueller, Beatrice U; Pabst, Thomas  (2010). Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia. Journal of cellular and molecular medicine, 14 (6B) , 1509-19More Information

Lin, Qiushi; Chen, Dahu; Timchenko, Nikolai A; Medrano, Estela E  (2010). SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta. Cell cycle (Georgetown, Tex.), 9 (9) , 1684-9

Willis-Martinez, Danielle; Richards, Hunter W; Timchenko, Nikolai A; Medrano, Estela E  (2010). Role of HDAC1 in senescence, aging, and cancer. Experimental gerontology, 45 (4) , 279-85More Information

Chen, Dahu; Lin, Qiushi; Box, Neil; Roop, Dennis; Ishii, Shunsuke; Matsuzaki, Koichi; Fan, Tao; Hornyak, Thomas J; Reed, Jon A; Stavnezer, Ed; Timchenko, Nikolai A; Medrano, Estela E  (2009). SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment cell & melanoma research, 22 (6) , 761-72More Information

Salisbury, Elizabeth; Schoser, Benedikt; Schneider-Gold, Christiane; Wang, Guo-Li; Huichalaf, Claudia; Jin, Bingwen; Sirito, Mario; Sarkar, Partha; Krahe, Ralf; Timchenko, Nikolai A; Timchenko, Lubov T  (2009). Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients. The American journal of pathology, 175 (2) , 748-62More Information

Jin, Jingling; Wang, Guo-Li; Salisbury, Elizabeth; Timchenko, Lubov; Timchenko, Nikolai A  (2009). GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy. Cell cycle (Georgetown, Tex.), 8 (15) , 2356-9

Jin, Jingling; Wang, Guo-Li; Shi, Xiurong; Darlington, Gretchen J; Timchenko, Nikolai A  (2009). The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Molecular and cellular biology, 29 (14) , 3867-80More Information

Jin, Jingling; Wang, Guo-Li; Timchenko, Lubov; Timchenko, Nikolai A  (2009). GSK3beta and aging liver. Aging, 1 (6) , 582-5

Timchenko, Nikolai A  (2009). Aging and liver regeneration. Trends in endocrinology and metabolism: TEM, 20 (4) , 171-6More Information

Wang, Guo-Li; Salisbury, Elizabeth; Shi, Xiurong; Timchenko, Lubov; Medrano, Estela E; Timchenko, Nikolai A  (2008). HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice. The Journal of biological chemistry, 283 (38) , 26169-78More Information

Wang, Guo-Li; Salisbury, Elizabeth; Shi, Xiurong; Timchenko, Lubov; Medrano, Estela E; Timchenko, Nikolai A  (2008). HDAC1 promotes liver proliferation in young mice via interactions with C/EBPbeta. The Journal of biological chemistry, 283 (38) , 26179-87More Information

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Timchenko, Nikolai A  (2008). Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines. Experimental cell research, 314 (7) , 1626-39More Information

Harrison-Findik, Duygu Dee; Klein, Elizabeth; Crist, Callie; Evans, John; Timchenko, Nikolai; Gollan, John  (2007). Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology (Baltimore, Md.), 46 (6) , 1979-85More Information

Smith, Roy G; Sun, Yuxiang; Jiang, Hong; Albarran-Zeckler, Rosie; Timchenko, Nikolai  (2007). Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Annals of the New York Academy of Sciences, 1119, 147-64More Information

Choi, William T; Folsom, Matthew R; Azim, Mohammed F; Meyer, Claus; Kowarz, Eric; Marschalek, Rolf; Timchenko, Nikolai A; Naeem, Rizwan C; Lee, Dean A  (2007). C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL. Cancer genetics and cytogenetics, 177 (2) , 108-14More Information

Bandyopadhyay, Debdutta; Curry, Jonathan L; Lin, Qiushi; Richards, Hunter W; Chen, Dahu; Hornsby, Peter J; Timchenko, Nikolai A; Medrano, Estela E  (2007). Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging cell, 6 (4) , 577-91More Information

Huichalaf, Claudia H; Sakai, Keiko; Wang, Guo-Li; Timchenko, Nikolai A; Timchenko, Lubov  (2007). Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis. Gene, 396 (2) , 391-402More Information

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Sun, Yuxiang; Albrecht, Jeffrey H; Smith, Roy G; Timchenko, Nikolai A  (2007). Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex. The Journal of biological chemistry, 282 (2) , 1468-78More Information

Timchenko, Lubov T; Salisbury, Elizabeth; Wang, Guo-Li; Nguyen, Heather; Albrecht, Jeffrey H; Hershey, John W B; Timchenko, Nikolai A  (2006). Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. The Journal of biological chemistry, 281 (43) , 32806-19More Information

Lee, Young-Jin; Jones, Letetia C; Timchenko, Nikolai A; Perrotti, Danilo; Tenen, Daniel G; Kogan, Scott C  (2006). CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities. Blood, 108 (7) , 2416-9More Information

Karagiannides, Iordanes; Thomou, Thomas; Tchkonia, Tamara; Pirtskhalava, Tamar; Kypreos, Kyriakos E; Cartwright, Andrew; Dalagiorgou, Georgia; Lash, Timothy L; Farmer, Stephen R; Timchenko, Nikolai A; Kirkland, James L  (2006). Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. The Journal of biological chemistry, 281 (32) , 23025-33More Information

Harrison-Findik, Duygu Dee; Schafer, Denise; Klein, Elizabeth; Timchenko, Nikolai A; Kulaksiz, Hasan; Clemens, Dahn; Fein, Evelyn; Andriopoulos, Billy; Pantopoulos, Kostas; Gollan, John  (2006). Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. The Journal of biological chemistry, 281 (32) , 22974-82More Information

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Sun, Yuxiang; Albrecht, Jeffrey H; Smith, Roy G; Timchenko, Nikolai A  (2006). Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes. Molecular and cellular biology, 26 (7) , 2570-82More Information

Helbling, Daniel; Mueller, Beatrice U; Timchenko, Nikolai A; Schardt, Julian; Eyer, Myriam; Betts, David R; Jotterand, Martine; Meyer-Monard, Sandrine; Fey, Martin F; Pabst, Thomas  (2005). CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Blood, 106 (4) , 1369-75More Information

Schwahn, Denise J; Timchenko, Nikolai A; Shibahara, Shigeki; Medrano, Estela E  (2005). Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 18 (3) , 203-13More Information

Timchenko, Nikolai A; Wang, Gou-Li; Timchenko, Lubov T  (2005). RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2. The Journal of biological chemistry, 280 (21) , 20549-57More Information

Bales, Elise; Mills, Lisa; Milam, Nancy; McGahren-Murray, Mollianne; Bandyopadhyay, Debdutta; Chen, Dahu; Reed, Jon A; Timchenko, Nikolai; van den Oord, Joost J; Bar-Eli, Menashe; Keyomarsi, Khandan; Medrano, Estela E  (2005). The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo. Cancer research, 65 (3) , 692-7

Wang, Guo-Li; Timchenko, Nikolai A  (2005). Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein. Molecular and cellular biology, 25 (4) , 1325-38More Information

Helbling, Daniel; Mueller, Beatrice U; Timchenko, Nikolai A; Hagemeijer, Anne; Jotterand, Martine; Meyer-Monard, Sandrine; Lister, Andrew; Rowley, Janet D; Huegli, Barbara; Fey, Martin F; Pabst, Thomas  (2004). The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin. Proceedings of the National Academy of Sciences of the United States of America, 101 (36) , 13312-7More Information

Baldwin, Brenda R; Timchenko, Nikolai A; Zahnow, Cynthia A  (2004). Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells. Molecular and cellular biology, 24 (9) , 3682-91

Wang, Guo-Li; Iakova, Polina; Wilde, Margie; Awad, Samir; Timchenko, Nikolai A  (2004). Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes & development, 18 (8) , 912-25More Information

Timchenko, Nikolai A; Patel, Roma; Iakova, Polina; Cai, Zong-Jin; Quan, Ling; Timchenko, Lubov T  (2004). Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis. The Journal of biological chemistry, 279 (13) , 13129-39More Information

Iakova, Polina; Wang, Guo-Li; Timchenko, Lubov; Michalak, Marek; Pereira-Smith, Olivia M; Smith, James R; Timchenko, Nikolai A  (2004). Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. The EMBO journal, 23 (2) , 406-17More Information

Yan, Yan; Phan, Leuyen; Yang, Fan; Talpaz, Moshe; Yang, Yu; Xiong, Zeyu; Ng, Bernard; Timchenko, Nikolai A; Wu, Catherine J; Ritz, Jerome; Wang, Hong; Yang, Xiao-Feng  (2004). A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. Journal of immunology (Baltimore, Md. : 1950), 172 (1) , 651-60

Timchenko, Nikolai AOld livers--C/EBPalpha meets new partners. Cell cycle (Georgetown, Tex.), 2 (5) , 445-6

Iakova, Polina; Awad, Samir S; Timchenko, Nikolai A  (2003). Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell, 113 (4) , 495-506

Timchenko, Lubov T; Iakova, Polina; Welm, Alana L; Cai, Z-J; Timchenko, Nikolai A  (2002). Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins. Molecular and cellular biology, 22 (20) , 7242-57

Welm, Alana L; Timchenko, Nikolai A; Ono, Yasuko; Sorimachi, Hiroyuki; Radomska, Hannah S; Tenen, Daniel G; Lekstrom-Himes, Julie; Darlington, Gretchen J  (2002). C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells. The Journal of biological chemistry, 277 (37) , 33848-56More Information

Rickheim, David G; Nelsen, Christopher J; Fassett, John T; Timchenko, Nikolai A; Hansen, Linda K; Albrecht, Jeffrey H  (2002). Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology (Baltimore, Md.), 36 (1) , 30-8More Information

Wang, Hongmei; Goode, Triona; Iakova, Polina; Albrecht, Jeffrey H; Timchenko, Nikolai A  (2002). C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest. The EMBO journal, 21 (5) , 930-41More Information

Lewis, Kyle; Valanejad, Leila; Cast, Ashley; Wright, Mary; Wei, Christina; Iakova, Polina; Stock, Lauren; Karns, Rebekah; Timchenko, Lubov; Timchenko, Nikolai  (2017). RNA binding protein CUGBP1 inhibits liver cancer in a phosphorylation dependent manner. Molecular and cellular biologyMore Information

Valanejad, Leila; Lewis, Kyle; Wright, Mary; Jiang, Yanjun; D'Souza, Amber; Karns, Rebekah; Sheridan, Rachel; Gupta, Anita; Bove, Kevin; Witte, David; Geller, James; Tiao, Gregory; Nelson, David L; Timchenko, Lubov; Timchenko, Nikolai  (2017). FXR-Gankyrin axis is involved in development of pediatric liver cancer. CarcinogenesisMore Information

Tiao, Gregory; Geller, James; Timchenko, Nikolai A  (2016). Generation of pediatric liver cancer patient-derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments. Hepatology (Baltimore, Md.), 64 (4) , 1017-9More Information

Jin, Jingling; Valanejad, Leila; Nguyen, Thuy Phuong; Lewis, Kyle; Wright, Mary; Cast, Ashley; Stock, Lauren; Timchenko, Lubov; Timchenko, Nikolai A  (2016). Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease. Cell reports, 16 (3) , 744-56More Information

Valanejad, Leila; Timchenko, Nikolai  (2016). Akt-FoxO1 axis controls liver regeneration. Hepatology (Baltimore, Md.), 63 (5) , 1424-6More Information

Khanal T.;Leung Y.K.;Jiang W.;Timchenko N.;Ho S.M.;Kim K.  (07-01-2019). NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver in. FASEB Journal, 33 (7) , 8335-8348More Information

Wang M.;Weng W.C.;Stock L.;Lindquist D.;Martinez A.;Gourdon G.;Timchenko N.;Snape M.;Timchenkoa L.  (01-01-2019). Correction of glycogen synthase kinase 3? in myotonic dystrophy 1 reduces the mutant RNA and improve. Molecular and Cellular Biology, 39 (21) More Information

Valanejad L.;Cast A.;Wright M.;Bissig K.;Karns R.;Weirauch M.;Timchenko N.  (12-01-2018). PARP1 activation increases expression of modified tumor suppressors and pathways underlying developm. Communications Biology, 1 (1) More Information

Nguyen P.;Valanejad L.;Cast A.;Wright M.;Garcia J.;El-Serag H.;Karns R.;Timchenko N.  (08-07-2018). Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of c. Cell Reports, 24 (6) , 1597-1609More Information

Rodriguez K.;Cast A.;Timchenko N.  (08-01-2018). Correction of aging phenotype in the liver. Aging, 10 (8) , 1795-1796More Information

Wei C.;Stock L.;Schneider-Gold C.;Sommer C.;Timchenko N.A.;Timchenko L.  (07-01-2018). Reduction of cellular nucleic acid binding protein encoded by a myotonic dystrophy type 2 gene cause. Molecular and Cellular Biology, 38 (14) More Information

Cast A.;Valanejad L.;Wright M.;Nguyen P.;Gupta A.;Zhu L.;Shin S.;Timchenko N.  (05-01-2018). C/EBP?-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive . Hepatology, 67 (5) , 1857-1871More Information

Wei C.;Stock L.;Valanejad L.;Zalewski Z.;Karns R.;Puymirat J.;Nelson D.;Witte D.;Woodgett J.;Timchenko N.;Timchenko L.  (04-01-2018). Correction of GSK3? at young age prevents muscle pathology in mice with myotonic dystrophy type 1. FASEB Journal, 32 (4) , 2073-2085More Information

Timchenko N.  (03-01-2018). Mitochondrial and anabolic pathways in hepatocellular carcinoma. Hepatology, 67 (3) , 823-825More Information

Guillory B.;Jawanmardi N.;Iakova P.;Anderson B.;Zang P.;Timchenko N.;Garcia J.  (02-01-2018). Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBP?-p300. Aging Cell, 17 (1) More Information

D'Souza A.;Jiang Y.;Cast A.;Valanejad L.;Wright M.;Lewis K.;Kumbaji M.;Shah S.;Smithrud D.;Karns R.;Shin S.;Timchenko N.  (01-01-2018). Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. Cellular and Molecular Gastroenterology and Hepatology, 6 (3) , 239-255More Information

He Q.;Wang F.;Honda T.;Lindquist D.;Dillman J.;Timchenko N.;Redington A.  (10-01-2017). Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in . Tumor Biology, 39 (10) , 1-8More Information

Lin Q.;Chen D.;Timchenko N.;Medrano E.  (05-01-2010). SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGF?. Cell Cycle, 9 (9) , 1684-1689More Information

McFie P.;Wang G.;Timchenko N.;Wilson H.;Hu X.;Roesler W.  (06-30-2006). Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of C. Journal of Biological Chemistry, 281 (26) , 18069-18080More Information

Rickheim D.;Nelsen C.;Fassett J.;Timchenko N.;Hansen L.;Albrecht J.  (01-01-2002). Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology, 36 (1) , 30-38More Information

Nelsen C.;Rickheim D.;Timchenko N.;Stanley M.;Albrecht J.  (12-01-2001). Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth i. Cancer Research, 61 (23) , 8564-8568

Leung J.;Berube N.;Venable S.;Ahmed S.;Timchenko N.;Pereira-Smith O.  (10-19-2001). MRG15 Activates the B-myb Promoter through Formation of a Nuclear Complex with the Retinoblastoma Pr. Journal of Biological Chemistry, 276 (42) , 39171-39178More Information

Timchenko N.;Iakova P.;Cai Z.;Smith J.;Timchenko L.  (10-10-2001). Molecular basis for impaired muscle differentiation in myotonic dystrophy. Molecular and Cellular Biology, 21 (20) , 6927-6938More Information

Bandyopadhyay D.;Timchenko N.;Suwa T.;Hornsby P.;Campisi J.;Medrano E.  (08-15-2001). The human melanocyte: A model system to study the complexity of cellular aging and transformation in. Experimental Gerontology, 36 (8) , 1265-1275More Information

Timchenko N.;Cai Z.;Welm A.;Reddy S.;Ashizawa T.;Timchenko L.  (03-16-2001). RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1. Journal of Biological Chemistry, 276 (11) , 7820-7826More Information

Wang H.;Iakova P.;Wilde M.;Welm A.;Goode T.;Roesler W.;Timchenko N.  (01-01-2001). C/EBP? arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Molecular Cell, 8 (4) , 817-828More Information

Welm A.;Mackey S.;Timchenko L.;Darlington G.;Timchenko N.  (09-01-2000). Translational induction of liver-enriched transcriptional inhibitory protein during acute phase resp. Journal of Biological Chemistry, 275 (35) , 27406-27413More Information

Timchenko N.;Welm A.;Lu X.;Timchenko L.  (11-15-1999). CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBP? mRNA and regulates transl. Nucleic Acids Research, 27 (22) , 4517-4525More Information

Timchenko N.;Wilde M.;Iakova P.;Albrecht J.;Darlington G.  (09-01-1999). E2F/p107 and E2F/p130 complexes are regulated by C/EBP? in 3T3-L1 adipocytes. Nucleic Acids Research, 27 (17) , 3621-3630More Information

Timchenko N.A.;Wilde M.;Darlington G.J.  (04-01-1999). C/EBP? regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Molecular and Cellular Biology, 19 (4) , 2936-2945

Welm A.L.;Timchenko N.A.;Darlington G.J.  (03-01-1999). C/EBP? regulates generation of C/EBP? isoforms through activation of specific proteolytic cleavage. Molecular and Cellular Biology, 19 (3) , 1695-1704

Burgess-Beusse B.;Timchenko N.;Darlington G.  (02-28-1999). CCAAT/enhancer binding protein ? (C/EBP? is an important mediator of mouse C/EBP? protein isoform pr. Hepatology, 29 (2) , 597-601More Information

Lu X.;Timchenko N.;Timchenko L.  (01-26-1999). Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystroph. Human Molecular Genetics, 8 (1) , 53-60More Information

Timchenko N.;Wilde M.;Kosai K.;Heydari A.;Bilyeu T.;Finegold M.;Mohamedali K.;Richardson A.;Darlington G.  (07-01-1998). Regenerating livers of old rats contain high levels of C/EBP? that correlate with altered expression. Nucleic Acids Research, 26 (13) , 3293-3299More Information

Timchenko N.A.;Harris T.E.;Wilde M.;Bilyeu T.A.;Burgess-Beusse B.L.;Finegold M.J.;Darlington G.J.  (12-01-1997). CCAAT/enhancer binding protein ? regulates p21 protein and hepatocyte proliferation in newborn mice. Molecular and Cellular Biology, 17 (12) , 7353-7361

Roberts R.;Timchenko N.;Miller J.;Reddy S.;Caskey C.;Swanson M.;Timchenko L.  (11-25-1997). Altered phosphorylation and intracellular distribution of a (CUG)n triplet re. Proceedings of the National Academy of Sciences of the United States of America, 94 (24) , 13221-13226More Information

Timchenko L.;Miller J.;Timchenko N.;Devore D.;Datar K.;Lin L.;Roberts R.;Thomas Caskey C.;Swanson M.  (11-30-1996). Identification of a (CUG)(n) triplet repeat RNA-binding protein and its expression in myotonic dystr. Nucleic Acids Research, 24 (22) , 4407-4414More Information

Timchenko N.;Wilde M.;Nakanishi M.;Smith J.;Darlington G.  (04-01-1996). CCAAT/enhancer-binding protein ? (C/EBP?) inhibits cell proliferation through the p21 (WAF-1/CIP-1/S. Genes and Development, 10 (7) , 804-815More Information

Timchenko L.;Timchenko N.;Caskey C.;Roberts R.  (01-01-1996). Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: Implications for my. Human Molecular Genetics, 5 (1) , 115-121More Information

Timchenko N.;Wilson D.R.;Taylor L.R.;Abdelsayed S.;Wilde M.;Sawadogo M.;Darlington G.J.  (01-01-1995). Autoregulation of the human C/EBP? gene by stimulation of upstream stimulatory factor binding. Molecular and Cellular Biology, 15 (3) , 1192-1202

Duniak V.;Timchenko N.  (07-01-1994). DNA fragment DARC146 from a complex form of DNA polymerase alpha contains several nuclear protein bi. Molekulyarnaya Biologiya, 28 (4) , 822-831

Timchenko N.;Luniak V.;Duniak A.  (07-01-1994). Segments initiating replication of the dihydrofolate reductase domain and the DNA fragment DARC146 i. Molekulyarnaya Biologiya, 28 (4) , 865-874

Luniak V.;Filatov M.;Ibatullin F.;Timchenko N.  (01-01-1993). The interaction of nuclear proteins with bent DNA located in an autonomously replicating DARC146 seq. Tsitologiya, 35 (5) , 84-90

Timchenko N.;Zhuchenko O.;Timchenko L.;Iguchi-Ariga S.;Ariga H.;Bozhkov V.;Tomilin N.  (01-01-1991). Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver int. Biomedical science, 2 (6) , 595-600

Zhuchenko O.;Timchenko L.;Timchenko N.  (06-22-1990). Increased expression of genes coding for replication proteins in the DNA synthesis period. Molekulyarnaya Biologiya, 24 (3) , 824-831

Timchenko N.;Shcherbakov O.;Krutyakov V.;Filatov M.  (06-22-1990). Autonomous replication of plasmids bearing DNA fragments from rat liver ?-polymerase complex. Molekulyarnaya Biologiya, 24 (3) , 814-823

Timchenko N.;Belyakova N.;Timchenko L.;Krutyakov V.  (01-01-1989). Characterization of DNA isolated from a complex form of DNA polymerase ? from rat liver. Molekulyarnaya Biologiya, 23 (4) , 1171-1176

Timchenko L.;Timchenko N.;Giliano N.;Noskin L.  (01-01-1988). Increased expression of some genes in rat liver after whole-body X-irradiation. Radiobiologiya, 28 (2) , 166-171

Timchenko N.;Shevelev I.;Drobchenko S.;Zhuchenko O.;Krutjakov V.  (01-01-1988). Isolation and characterization of endonuclease tightly bound with rat liver DNA polymerase ?. Molekulyarnaya Biologiya, 22 (4) , 976-983

Baranov V.;Schwartzman A.;Gorbunova V.;Gaitskhoki V.;Rubtsov N.;Timchenko N.;Neifakh S.  (12-01-1987). Chromosomal localization of ceruoplasmin and transferrin genes in laboratory rats, mice and in man b. Chromosoma, 96 (1) , 60-66More Information

Timchenko N.;Timchenko L.;Bilobrov S.;Zhuchenko O.;Krutiakov V.  (05-01-1987). Identification and characteristics of mRNA's showing increased levels during DNA replication. Molekulyarnaya Biologiya, 21 (3) , 640-646

Timchenko N.;Timchenko L.;Krutiakov V.  (12-01-1986). Cloning of mRNA nucleotide sequences amplified during DNA replication in the regenerating liver. Molekuliarnaia genetika, mikrobiologiia i virusologiia (12) , 23-25

Salikhov T.;Timchenko L.;Timchenko N.  (11-01-1984). Isolation and properties of transferrin messenger RNA from rat liver. Chemistry of Natural Compounds, 20 (6) , 723-729More Information

Ryskov A.;Timchenko N.;Timchenko L.  (01-01-1984). Cloning of double-stranded DNA transcribed from rat transferrin messenger RNA. Molekulyarnaya Biologiya, 18 (1) , 104-114

Timchenko N.;Timchenko L.;Schwartzman A.  (01-01-1983). Physicochemical and functional characteristics of transferrin messenger RNA from rat liver. Molekulyarnaya Biologiya, 17 (2) , 322-329

Gaitskhoki V.;Timchenko N.;Timchenko L.  (01-01-1982). Biosynthesis and post-translational maturation of transferrin in subcellular fractions of rat liver. Biokhimiya, 47 (1) , 13-18

Ga?tskhoki V.;Timchenko N.;Timchenko L.;Puchkova L.;Aslanov K.  (08-01-1981). Properties of rat liver polyribosomes synthesizing transferrin. Biokhimiya, 46 (8) , 1426-1434

Lutz, Maggie; Levanti, Miranda; Karns, Rebekah; Gourdon, Genevieve; Lindquist, Diana; Timchenko, Nikolai A; Timchenko, Lubov  (2023). Therapeutic Targeting of the GSK3β-CUGBP1 Pathway in Myotonic Dystrophy. International journal of molecular sciences, 24 (13) More Information

Brown, Anthony; Pan, Qingfei; Fan, Li; Indersie, Emilie; Tian, Cheng; Timchenko, Nikolai; Li, Liyuan; Hansen, Baranda S; Tan, Haiyan; Lu, Meifen; Peng, Junmin; Pruett-Miller, Shondra M; Yu, Jiyang; Cairo, Stefano; Zhu, Liqin  (2023). Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse. Communications biology, 6 (1) , 249More Information

Brown, Anthony; Pan, Qingfei; Fan, Li; Indersie, Emilie; Tian, Cheng; Timchenko, Nikolai; Li, Liyuan; Hansen, Baranda S; Tan, Haiyan; Lu, Meifen; Peng, Junmin; Pruett-Miller, Shondra M; Yu, Jiyang; Cairo, Stefano; Zhu, Liqin  (2023). Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse. bioRxiv : the preprint server for biologyMore Information

Gulati, Ruhi; Hanlon, Margaret A; Lutz, Maggie; Quitmeyer, Tyler; Geller, James; Tiao, Gregory; Timchenko, Lubov; Timchenko, Nikolai  (2022). Phosphorylation-Mediated Activation of β-Catenin-TCF4-CEGRs/ALCDs Pathway Is an Essential Event in Development of Aggressive Hepatoblastoma. Cancers, 14 (24) More Information

Gulati, Ruhi; Johnston, Michael; Rivas, Maria; Cast, Ashley; Kumbaji, Meenasri; Hanlon, Margaret A; Lee, Sanghoon; Zhou, Ping; Lake, Charissa; Schepers, Emily; Min, Kyung-Won; Yoon, Je-Hyun; Karns, Rebekah; Reid, Lola M; Lopez-Terrada, Dolores; Timchenko, Lubov; Parameswaran, Sreeja; Weirauch, Matthew T; Ranganathan, Sarangarajan; Bondoc, Alexander; Geller, James; Tiao, Gregory; Shin, Soona; Timchenko, Nikolai  (2022). β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Hepatology communications, 6 (10) , 2950-2963More Information

D'Souza, Amber M; Gnanamony, Manu; Thomas, Maria; Hanley, Peter; Kanabar, Dipti; de Alarcon, Pedro; Muth, Aaron; Timchenko, Nikolai  (2022). Second Generation Small Molecule Inhibitors of Gankyrin for the Treatment of Pediatric Liver Cancer. Cancers, 14 (13) More Information

Johnston, Michael Edward; Rivas, Maria Prates; Nicolle, Delphine; Gorse, Aurore; Gulati, Ruhi; Kumbaji, Meenasri; Weirauch, Matthew T; Bondoc, Alexander; Cairo, Stefano; Geller, James; Tiao, Gregory; Timchenko, Nikolai  (2021). Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models. Hepatology (Baltimore, Md.), 74 (4) , 2201-2215More Information

D'Souza, Amber M; Cast, Ashley; Kumbaji, Meenasri; Rivas, Maria; Gulati, Ruhi; Johnston, Michael; Smithrud, David; Geller, James; Timchenko, Nikolai  (2021). Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin. Frontiers in pharmacology, 12, 580722More Information

Johnston, Michael E; Timchenko, Nikolai  (2021). Molecular signatures of aggressive pediatric liver cancer. Archives of stem cell and therapy, 2 (1) , 1-4

Rivas, Maria; Johnston, Michael E; Gulati, Ruhi; Kumbaji, Meenasri; Margues Aguiar, Talita Ferreira; Timchenko, Lubov; Krepischi, Ana; Shin, Soona; Bondoc, Alexander; Tiao, Gregory; Geller, James; Timchenko, Nikolai  (2021). HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer. Cellular and molecular gastroenterology and hepatology, 12 (5) , 1669-1682More Information

Timchenko, Nikolai A  (2021). Help for Sick Kids: New Insights Into Hepatoblastoma. Cellular and molecular gastroenterology and hepatology, 12 (1) , 350-351More Information

Rivas, Maria Prates; Aguiar, Talita Ferreira Marques; Maschietto, Mariana; Lemes, Renan B; Caires-Júnior, Luiz Carlos; Goulart, Ernesto; Telles-Silva, Kayque Alves; Novak, Estela; Cristofani, Lilian Maria; Odone, Vicente; Cypriano, Monica; de Toledo, Silvia Regina Caminada; Carraro, Dirce Maria; Escobar, Melissa Quintero; Lee, Hana; Johnston, Michael; da Costa, Cecilia Maria Lima; da Cunha, Isabela Werneck; Tasic, Ljubica; Pearson, Peter L; Rosenberg, Carla; Timchenko, Nikolai; Krepischi, Ana Cristina Victorino  (2020). Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 42 (12) , 1010428320977124More Information

Cast, Ashley; Kumbaji, Meenasri; D'Souza, Amber; Rodriguez, Katherine; Gupta, Anita; Karns, Rebekah; Timchenko, Lubov; Timchenko, Nikolai  (2019). Liver Proliferation Is an Essential Driver of Fibrosis in Mouse Models of Nonalcoholic Fatty Liver Disease. Hepatology communications, 3 (8) , 1036-1049More Information

Academic - Cincinnati Children's Hospital Medical Center
Division of Pediatric Surgery
Cincinnati  Ohio, 45229
Phone: 513-636-0129
nikolai.timchenko@cchmc.org