Professional Summary
Alexander (Sander) Vinks, PhD, PharmD, FCP, is Professor Emeritus of Pediatrics and Pharmacology at the University of Cincinnati, College of Medicine. He currently is a partner with NDA Partners, a life sciences management consulting and contract development organization (CDO) focused on providing product development and regulatory services to the pharmaceutical, biotechnology, and medical device industries worldwide. Dr. Vinks' practice include clinical pharmacology and pharmacometrics services as part of Model-informed Drug Development (MIDD) and Model-informed Precision Dosing (MIPD) strategies.
While at Cincinnati Children's, he was the Cincinnati Children’s Research Foundation Endowed Chair and Director of the Division of Clinical Pharmacology. He served as the program director of the Eunice Kennedy Shriver National Institutes of Child Health & Human Development (NICHD) Pediatric Clinical Pharmacology T32 training program at Cincinnati Children’s Hospital Medical Center. He was Co-Director of Cincinnati Children’s Genetic Pharmacology Service, and Scientific Director for Pharmacy Research in the Division of Patient Services. He served as the director of the multidisciplinary Pharmacometrics Center of Excellence which spearheads a precision therapeutics implementation program.
Dr. Vinks’ research interests include population pharmacokinetic-pharmacodynamic (PK/PD) modeling, physiologically-based pharmacokinetics (PBPK), and pharmacogenetics/genomics. He is a partner with NDA partners and consultant in the application of population and simulation approaches to inform adult and pediatric clinical trial design as part of model-informed drug development (MIDD) and therapeutic drug management through the implementation of model-informed precision dosing (MIPD) strategies.
He has published over 280 peer reviewed research manuscripts, invited reviews and editorials, and book chapters on clinical pharmacology and patient oriented research related topics in a variety of patient populations. He was the Editor of a textbook on the Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics. He is a fellow of the American College of Clinical Pharmacology (ACCP) and served as associate editor for Clinical Pharmacology & Therapeutics, the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).
Publications
Peer Reviewed Publications
Fukuda, Tsuyoshi; Goebel, Jens; Cox, Shareen; Maseck, Denise; Zhang, Kejian; Sherbotie, Joseph R; Ellis, Eileen N; James, Laura P; Ward, Robert M; Vinks, Alexander A (2012. ) UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients.Therapeutic drug monitoring, , 34 (6 ) ,671-679 More Information
Wiles, Jason R; Vinks, Alexander A; Akinbi, Henry (2012. ) Federal Legislation and the Advancement of Neonatal Drug Studies.The Journal of pediatrics, , More Information
Ngamprasertwong, Pornswan; Vinks, Alexander A; Boat, Anne (2012. ) Update in Fetal Anesthesia for the Ex Utero Intrapartum Treatment (EXIT) Procedure.International anesthesiology clinics, , 50 (4 ) ,26-40 More Information
Sherwin, Catherine M T; Saldaña, Shannon N; Bies, Robert R; Aman, Michael G; Vinks, Alexander A (2012. ) Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents.Therapeutic drug monitoring, , 34 (5 ) ,535-44 More Information
Sadhasivam, Senthilkumar; Krekels, Elke H J; Chidambaran, Vidya; Esslinger, Hope R; Ngamprasertwong, Pornswan; Zhang, Kejian; Fukuda, Tsuyoshi; Vinks, Alexander A Morphine clearance in children: does race or genetics matter?.Journal of opioid management, , 8 (4 ) ,217-26 More Information
Sherwin, Catherine M T; Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Brunner, Hermine I; Vinks, Alexander A (2012. ) Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus.British journal of clinical pharmacology, , 73 (5 ) ,727-40 More Information
Chidambaran, Vidya; Ngamprasertwong, Pornswan; Vinks, Alexander A; Sadhasivam, Senthilkumar (2012. ) Pharmacogenetics and anesthetic drugs. Current clinical pharmacology, , 7 (2 ) ,78-101
Hooper, David K; Fukuda, Tsuyoshi; Gardiner, Rhonda; Logan, Barbara; Roy-Chaudhury, Ashwini; Kirby, Cassie L; Vinks, Alexander A; Goebel, Jens (2012. ) Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation.Transplantation, , 93 (8 ) ,806-12 More Information
Saldaña, Shannon N; Hooper, David K; Froehlich, Tanya E; Campbell, Kathleen M; Prows, Cynthia A; Sadhasivam, Senthilkumar; Nick, Todd G; Seid, Michael; Vinks, Alexander A; Glauser, Tracy A (2011. ) Characteristics of successful recruitment in prospective pediatric pharmacogenetic studies.Clinical therapeutics, , 33 (12 ) ,2072-81 More Information
Sagcal-Gironella, Anna Carmela P; Sherwin, Catherine M T; Tirona, Rommel G; Rieder, Michael J; Brunner, Hermine I; Vinks, Alexander A (2011. ) Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study.Clinical therapeutics, , 33 (10 ) ,1524-36 More Information
Fukuda, Tsuyoshi; Brunner, Hermine I; Sagcal-Gironella, Anna Carmela P; Vinks, Alexander A (2011. ) Nonsteroidal anti-inflammatory drugs may reduce enterohepatic recirculation of mycophenolic acid in patients with childhood-onset systemic lupus erythematosus.Therapeutic drug monitoring, , 33 (5 ) ,658-62 More Information
Sherwin, Catherine M T; Ding, Lili; Kaplan, Jennifer; Spigarelli, Michael G; Vinks, Alexander A (2011. ) Optimal study design for pioglitazone in septic pediatric patients.Journal of pharmacokinetics and pharmacodynamics, , 38 (4 ) ,433-47 More Information
Merhar, Stephanie L; Schibler, Kurt R; Sherwin, Catherine M; Meinzen-Derr, Jareen; Shi, Jing; Balmakund, Tonya; Vinks, Alexander A (2011. ) Pharmacokinetics of levetiracetam in neonates with seizures.The Journal of pediatrics, , 159 (1 ) ,152-154.e3 More Information
Fukuda, Tsuyoshi; Goebel, Jens; Thøgersen, Håvard; Maseck, Denise; Cox, Shareen; Logan, Barbara; Sherbotie, Joseph; Seikaly, Mouin; Vinks, Alexander A (2011. ) Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients.Journal of clinical pharmacology, , 51 (3 ) ,309-20 More Information
Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Wiers, Kristina; Cox, Shareen; Nelson, Shannen; Dina, Blair; Sherwin, Catherine M T; Klein-Gitelman, Marisa S; Vinks, Alexander A; Brunner, Hermine I (2011. ) Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus.Seminars in arthritis and rheumatism, , 40 (4 ) ,307-13 More Information
Sherwin, Catherine M T; Fukuda, Tsuyoshi; Brunner, Hermine I; Goebel, Jens; Vinks, Alexander A (2011. ) The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease.Clinical pharmacokinetics, , 50 (1 ) ,1-24 More Information
Mehta, Parinda A; Vinks, Alexander A; Filipovich, Alexandra; Bleesing, Jack; Jodele, Sonata; Jordan, Michael B; Marsh, Rebecca; Tarin, Richard; Edwards, Stephanie; Fearing, Deborah; Lawrence, Julia; Davies, Stella M (2010. ) Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 16 (10 ) ,1458-62 More Information
Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Capparelli, Edmund V; Adamson, Peter C (2010. ) Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.The New England journal of medicine, , 362 (9 ) ,790-9 More Information
Vargus-Adams, Jilda N; McMahon, Mary A; Michaud, Linda J; Bean, Judy; Vinks, Alexander A (2010. ) Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique.PM & R : the journal of injury, function, and rehabilitation, , 2 (1 ) ,37-42 More Information
Prows, Cynthia A; Nick, Todd G; Saldaña, Shannon N; Pathak, Sanjeev; Liu, Chunyan; Zhang, Kejian; Daniels, Zachary S; Vinks, Alexander A; Glauser, Tracy A (2009. ) Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients.Journal of child and adolescent psychopharmacology, , 19 (4 ) ,385-94 More Information
Pestian, John; Spencer, Malik; Matykiewicz, Pawel; Zhang, Kejian; Vinks, Alexander A; Glauser, Tracy (2009. ) Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomedical informatics insights, , 2 ,19-29
Prausa, S E; Fukuda, T; Maseck, D; Curtsinger, K L; Liu, C; Zhang, K; Nick, T G; Sherbotie, J R; Ellis, E N; Goebel, J; Vinks, A A (2009. ) UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.Clinical pharmacology and therapeutics, , 85 (5 ) ,495-500 More Information
Rogers, Christin C; Alloway, Rita R; Alexander, J Wesley; Cardi, Michael; Trofe, Jennifer; Vinks, Alexander A Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study.Clinical transplantation, , 22 (3 ) ,281-91 More Information
Vinks, Alexander A; van Rossem, Ronald N; Mathôt, Ron A A; Heijerman, Harry G M; Mouton, Johan W (2007. ) Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation.Antimicrobial agents and chemotherapy, , 51 (9 ) ,3049-55 More Information
Cabovska, B; Cox, S L; Vinks, A A (2007. ) Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , 852 (1-2 ) ,497-504 More Information
Jiang, Zhengwen; Dragin, Nadine; Jorge-Nebert, Lucia F; Martin, Martha V; Guengerich, F Peter; Aklillu, Eleni; Ingelman-Sundberg, Magnus; Hammons, George J; Lyn-Cook, Beverly D; Kadlubar, Fred F; Saldana, Shannon N; Sorter, Michael; Vinks, Alexander A; Nassr, Nassr; von Richter, Oliver; Jin, Li; Nebert, Daniel W (2006. ) Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.Pharmacogenetics and genomics, , 16 (5 ) ,359-67 More Information
Mehta, Parinda; Vinks, Alexander; Filipovich, Alexandra; Vaughn, Gretchen; Fearing, Deborah; Sper, Christine; Davies, Stella (2006. ) High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 12 (2 ) ,235-40 More Information
Williams, Michael T; Brown, Carrie A; Skelton, Matthew R; Vinks, Alexander A; Vorhees, Charles V Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats.Neurotoxicology and teratology, , 26 (6 ) ,849-56 More Information
Vinks, Alexander A; Den Hollander, Jan G; Overbeek, Shelley E; Jelliffe, Roger W; Mouton, Johan W (2003. ) Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis. Antimicrobial agents and chemotherapy, , 47 (2 ) ,541-7
Vinks, Alexander A (2002. ) The application of population pharmacokinetic modeling to individualized antibiotic therapy. International journal of antimicrobial agents, , 19 (4 ) ,313-22
Poweleit, Ethan A; Vinks, Alexander A; Mizuno, Tomoyuki (2023. ) Artificial Intelligence and Machine Learning Approaches to Facilitate Therapeutic Drug Management and Model-Informed Precision Dosing.Therapeutic drug monitoring, , More Information
Tang Girdwood, Sonya; Tang, Peter; Fenchel, Matthew; Dong, Min; Stoneman, Erin; Jones, Rhonda; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Diseroad, Emily; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A (2023. ) Pharmacokinetic Parameters over Time during Sepsis and the Association of Target Attainment and Outcomes in Critically Ill Children and Young Adults Receiving Ceftriaxone.Pharmacotherapy, , More Information
Tang Girdwood, Sonya; Hasson, Denise; Caldwell, J Timothy; Slagle, Cara; Dong, Shun; Fei, Lin; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Goldstein, Stuart L (2023. ) Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury.The Journal of antimicrobial chemotherapy, , 78 (2 ) ,478-487 More Information
Ramsey, Laura B; Prows, Cynthia A; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Quinn, Charles T; Teusink-Cross, Ashley; Girdwood, Sonya Tang; Dawson, D Brian; Vinks, Alexander A; Glauser, Tracy A (2023. ) Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, , More Information
Tang Girdwood, Sonya; Pavia, Kathryn; Paice, Kelli; Hambrick, H Rhodes; Kaplan, Jennifer; Vinks, Alexander A (2022. ) β-lactam precision dosing in critically ill children: Current state and knowledge gaps.Frontiers in pharmacology, , 13 ,1044683 More Information
Colman, Ruben J; Samuels, Abigail; Mizuno, Tomoyuki; Punt, Nieko; Vinks, Alexander A; Minar, Phillip (2022. ) Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease.Inflammatory bowel diseases, , More Information
Colman, Ruben J; Mizuno, Tomoyuki; Fukushima, Keizo; Haslam, David B; Hyams, Jeffrey S; Boyle, Brendan; Noe, Joshua D; D'Haens, Geert R; Van Limbergen, Johan; Chun, Kelly; Yang, Jane; Denson, Lee A; Ollberding, Nicholas J; Vinks, Alexander A; Minar, Phillip (2022. ) Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance.Alimentary pharmacology & therapeutics, , More Information
Miyagawa, Bradley; Lazear, Danielle; Hooper, David K; Vinks, Alexander A; Mizuno, Tomoyuki (2022. ) Model-informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient with Posterior Reversible Encephalopathy Syndrome.Therapeutic drug monitoring, , More Information
Whaley, Kaitlin G; Xiong, Ye; Karns, Rebekah; Hyams, Jeffrey S; Kugathasan, Subra; Boyle, Brendan M; Walters, Thomas D; Kelsen, Judith; LeLeiko, Neal; Shapiro, Jason; Waddell, Amanda; Fox, Sejal; Bezold, Ramona; Bruns, Stephanie; Widing, Robin; Haberman, Yael; Collins, Margaret H; Mizuno, Tomoyuki; Minar, Phillip; D'Haens, Geert R; Denson, Lee A; Vinks, Alexander A; Rosen, Michael J (2022. ) Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, , More Information
Yi, Jae-Sung; Perla, Sravan; Huang, Yan; Mizuno, Kana; Giordano, Frank J; Vinks, Alexander A; Bennett, Anton M (2022. ) Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines.Cardiovascular drugs and therapy, , 36 (4 ) ,589-604 More Information
van Hoogdalem, Matthijs W; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki (2022. ) A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome.Pharmacology & therapeutics, , 234 ,108045 More Information
Mizuno, Kana; Dandoy, Christopher E; Teusink-Cross, Ashley; Davies, Stella M; Vinks, Alexander A; Jodele, Sonata (2022. ) Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT.Blood advances, , 6 (5 ) ,1454-1463 More Information
Colman, Ruben J; Xiong, Ye; Mizuno, Tomoyuki; Hyams, Jeffrey S; Noe, Joshua D; Boyle, Brendan; D'Haens, Geert R; van Limbergen, Johan; Chun, Kelly; Yang, Jane; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip (2022. ) Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease.Alimentary pharmacology & therapeutics, , 55 (5 ) ,593-603 More Information
van Hoogdalem, Matthijs W; Johnson, Trevor N; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott L; Ward, Laura P; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki (2022. ) Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome.Clinical pharmacology and therapeutics, , 111 (2 ) ,496-508 More Information
Mizuno, Tomoyuki; Dong, Min; Taylor, Zachary L; Ramsey, Laura B; Vinks, Alexander A (2022. ) Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care.British journal of clinical pharmacology, , 88 (4 ) ,1418-1426 More Information
Tang Girdwood, Sonya; Dong, Min; Tang, Peter; Stoneman, Erin; Jones, Rhonda; Yunger, Toni; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Lahni, Patrick; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A (2022. ) Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Attainment.Antimicrobial agents and chemotherapy, , 66 (1 ) ,e0142721 More Information
Dong, Min; Emoto, Chie; Fukuda, Tsuyoshi; Arnold, Danielle E; Mehta, Parinda A; Marsh, Rebecca A; Vinks, Alexander A (2022. ) Model-informed precision dosing for alemtuzumab in paediatric and young adult patients undergoing allogeneic haematopoietic cell transplantation.British journal of clinical pharmacology, , 88 (1 ) ,248-259 More Information
Chandra, Sharat; Mizuno, Kana; Zhao, Junfang; Davies, Stella M; Marsh, Rebecca A; Fukuda, Tsuyoshi; Setchell, Kenneth D R; Vinks, Alexander A; Mehta, Parinda A (2022. ) Test-dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non-malignant disorders.British journal of clinical pharmacology, , 88 (1 ) ,115-127 More Information
Wong, Steven H; Marquet, Pierre; Cattaneo, Dario; Svinarov, Dobrin; Bergan, Stein; Walson, Philip; Vinks, Alexander A; Shipkova, Maria (2021. ) Therapeutic Drug Monitoring in the Era of Precision Medicine: Achievements, Gaps, and Perspectives-An Interview in Honor of Professor Charles Pippenger.Therapeutic drug monitoring, , 43 (6 ) ,719-727 More Information
Arnold, Danielle E; Emoto, Chie; Fukuda, Tsuyoshi; Dong, Min; Vinks, Alexander A; Lane, Adam; McIntosh, Kelly; Neumeier, Lisa; Lankester, Arjan C; Achini, Federica; Teusink-Cross, Ashley; Chandra, Sharat; Jordan, Michael B; Nelson, Adam S; Myers, Kasiani C; Davies, Stella M; Mehta, Parinda A; Marsh, Rebecca A (2021. ) A prospective pilot study of a novel alemtuzumab target concentration intervention strategy.Bone marrow transplantation, , 56 (12 ) ,3029-3031 More Information
Taylor, Zachary L; Thompson, Lauren E; Bear, Heather; Mizuno, Tomoyuki; Vinks, Alexander A; Ramsey, Laura B (2021. ) Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model.Clinical and translational science, , 14 (6 ) ,2267-2277 More Information
Dong, Min; Rodriguez, Anna V; Blankenship, Chelsea A; McPhail, Gary; Vinks, Alexander A; Hunter, Lisa L (2021. ) Pharmacokinetic modelling to predict risk of ototoxicity with intravenous tobramycin treatment in cystic fibrosis.The Journal of antimicrobial chemotherapy, , 76 (11 ) ,2923-2931 More Information
van Gelder, Teun; Vinks, Alexander A (2021. ) Machine Learning as a Novel Method to Support Therapeutic Drug Management and Precision Dosing.Clinical pharmacology and therapeutics, , 110 (2 ) ,273-276 More Information
Quinn, Charles T; Niss, Omar; Dong, Min; Pfeiffer, Amanda; Korpik, Jennifer; Reynaud, Mary; Bonar, Holly; Kalfa, Theodosia A; Smart, Luke R; Malik, Punam; Ware, Russell E; Vinks, Alexander A; McGann, Patrick T (2021. ) Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia.British journal of haematology, , 194 (3 ) ,617-625 More Information
McPhail, Brooks T; Emoto, Chie; Butler, Dawn; Fukuda, Tsuyoshi; Akinbi, Henry; Vinks, Alexander A (2021. ) Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches.Journal of clinical pharmacology, , 61 (7 ) ,857-870 More Information
Vinks, Alexander A; Barrett, Jeffrey S (2021. ) Model-Informed Pediatric Drug Development: Application of Pharmacometrics to Define the Right Dose for Children.Journal of clinical pharmacology, , 61 Suppl 1 ,S52-S59 More Information
Barrett, Jeffrey S; Barrett, Ryan F; Vinks, Alexander A (2021. ) Status Toward the Implementation of Precision Dosing in Children.Journal of clinical pharmacology, , 61 Suppl 1 ,S36-S51 More Information
Xiong, Ye; Mizuno, Tomoyuki; Colman, Ruben; Hyams, Jeffrey; Noe, Joshua D; Boyle, Brendan; Tsai, Yi-Ting; Dong, Min; Jackson, Kimberly; Punt, Nieko; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip (2021. ) Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease.Clinical pharmacology and therapeutics, , 109 (6 ) ,1639-1647 More Information
Karkoska, Kristine; Quinn, Charles T; Niss, Omar; Pfeiffer, Amanda; Dong, Min; Vinks, Alexander A; McGann, Patrick T (2021. ) Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia.American journal of hematology, , 96 (5 ) ,538-544 More Information
Zhao, Junfang; Sharat, Chandra; Mehta, Parinda A; Mizuno, Kana; Vinks, Alexander A; Setchell, Kenneth D R (2021. ) Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan.The journal of applied laboratory medicine, , 6 (3 ) ,625-636 More Information
Bergan, Stein; Brunet, Mercè; Hesselink, Dennis A; Johnson-Davis, Kamisha L; Kunicki, Paweł K; Lemaitre, Florian; Marquet, Pierre; Molinaro, Mariadelfina; Noceti, Ofelia; Pattanaik, Smita; Pawinski, Tomasz; Seger, Christoph; Shipkova, Maria; Swen, Jesse J; van Gelder, Teun; Venkataramanan, Raman; Wieland, Eberhard; Woillard, Jean-Baptiste; Zwart, Tom C; Barten, Markus J; Budde, Klemens; Dieterlen, Maja-Theresa; Elens, Laure; Haufroid, Vincent; Masuda, Satohiro; Millan, Olga; Mizuno, Tomoyuki; Moes, Dirk J A R; Oellerich, Michael; Picard, Nicolas; Salzmann, Linda; Tönshoff, Burkhard; van Schaik, Ron H N; Vethe, Nils Tore; Vinks, Alexander A; Wallemacq, Pierre; Åsberg, Anders; Langman, Loralie J (2021. ) Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.Therapeutic drug monitoring, , 43 (2 ) ,150-200 More Information
Tang Girdwood, Sonya C; Tang, Peter H; Murphy, Mark E; Chamberlain, Andrea R; Benken, Laura A; Jones, Rhonda L; Stoneman, Erin M; Kaplan, Jennifer M; Vinks, Alexander A (2021. ) Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children.Journal of clinical pharmacology, , 61 (4 ) ,565-573 More Information
Boucher, Alexander A; Dong, Min; Vinks, Alexander A; Marahatta, Anu; Howard, Thad A; Ware, Russell E; Nathan, Jaimie D; Abu-El-Haija, Maisam; Luchtman-Jones, Lori (2021. ) Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation.Journal of clinical pharmacology, , 61 (4 ) ,547-554 More Information
Weiss, Brian D; Wolters, Pamela L; Plotkin, Scott R; Widemann, Brigitte C; Tonsgard, James H; Blakeley, Jaishri; Allen, Jeffrey C; Schorry, Elizabeth; Korf, Bruce; Robison, Nathan J; Goldman, Stewart; Vinks, Alexander A; Emoto, Chie; Fukuda, Tsuyoshi; Robinson, Coretta T; Cutter, Gary; Edwards, Lloyd; Dombi, Eva; Ratner, Nancy; Packer, Roger; Fisher, Michael J (2021. ) NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, , 39 (7 ) ,797-806 More Information
Sebold, Alison J; Day, Alyssa M; Ewen, Joshua; Adamek, Jack; Byars, Anna; Cohen, Bernard; Kossoff, Eric H; Mizuno, Tomoyuki; Ryan, Matthew; Sievers, Jacqueline; Smegal, Lindsay; Suskauer, Stacy J; Thomas, Cameron; Vinks, Alexander; Zabel, T Andrew; Hammill, Adrienne M; Comi, Anne M (2021. ) Sirolimus Treatment in Sturge-Weber Syndrome.Pediatric neurology, , 115 ,29-40 More Information
Soul, Janet S; Bergin, Ann M; Stopp, Christian; Hayes, Breda; Singh, Avantika; Fortuno, Carmen R; O'Reilly, Deirdre; Krishnamoorthy, Kalpathy; Jensen, Frances E; Rofeberg, Valerie; Dong, Min; Vinks, Alexander A; Wypij, David; Staley, Kevin J (2021. ) A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.Annals of neurology, , 89 (2 ) ,327-340 More Information
Wright, Karen D; Yao, Xiaopan; London, Wendy B; Kao, Pei-Chi; Gore, Lia; Hunger, Stephen; Geyer, Russ; Cohen, Kenneth J; Allen, Jeffrey C; Katzenstein, Howard M; Smith, Amy; Boklan, Jessica; Nazemi, Kellie; Trippett, Tanya; Karajannis, Matthias; Herzog, Cynthia; Destefano, Joseph; Direnzo, Jennifer; Pietrantonio, Jay; Greenspan, Lianne; Cassidy, Danielle; Schissel, Debra; Perentesis, John; Basu, Mitali; Mizuno, Tomoyuki; Vinks, Alexander A; Prabhu, Sanjay P; Chi, Susan N; Kieran, Mark W (2021. ) A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma.Pediatric blood & cancer, , 68 (2 ) ,e28787 More Information
Mizuno, Tomoyuki; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott; Ward, Laura; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A (2021. ) Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome.Clinical pharmacokinetics, , 60 (2 ) ,249-259 More Information
Neely, Michael N; Vinks, Alexander A (2021. ) Roger W. Jelliffe, MD, FCP, FAAPS: A World Leader in Population Pharmacokinetic and Pharmacodynamic Modeling and Model-Based Target Controlled Individualized Dosing.Clinical pharmacology and therapeutics, , 109 (1 ) ,22-24 More Information
Peck, Richard W; Shahin, Mohamed H; Vinks, Alexander A (2021. ) Precision Dosing: The Clinical Pharmacology of Goldilocks.Clinical pharmacology and therapeutics, , 109 (1 ) ,11-14 More Information
van Hoogdalem, Matthijs W; McPhail, Brooks T; Hahn, David; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki (2021. ) Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics.Expert opinion on drug metabolism & toxicology, , 17 (1 ) ,87-103 More Information
Girdwood, Sonya Tang; Kaplan, Jennifer; Vinks, Alexander A (2021. ) Methodologic Progress Note: Opportunistic Sampling for Pharmacology Studies in Hospitalized Children.Journal of hospital medicine, , 16 (1 ) ,35-37 More Information
Cazelles, Remi; Shukla, Rajendra P; Ware, Russell E; Vinks, Alexander A; Ben-Yoav, Hadar (2020. ) Electrochemical Determination of Hydroxyurea in a Complex Biological Matrix Using MoS2-Modified Electrodes and Chemometrics.Biomedicines, , 9 (1 ) , More Information
Chen, Yewei; Sun, Li; Xu, Hong; Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A; Brunner, Hermine I; Li, Yifan; Li, Zhiping (2020. ) PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing.Frontiers in pharmacology, , 11 ,605060 More Information
Meier, Emily R; Creary, Susan E; Heeney, Matthew M; Dong, Min; Appiah-Kubi, Abena O; Nelson, Stephen C; Niss, Omar; Piccone, Connie; Quarmyne, Maa-Ohui; Quinn, Charles T; Saving, Kay L; Scott, John P; Talati, Ravi; Latham, Teresa S; Pfeiffer, Amanda; Shook, Lisa M; Vinks, Alexander A; Lane, Adam; McGann, Patrick T (2020. ) Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.Trials, , 21 (1 ) ,983 More Information
Ullrich, Nicole J; Prabhu, Sanjay P; Reddy, Alyssa T; Fisher, Michael J; Packer, Roger; Goldman, Stewart; Robison, Nathan J; Gutmann, David H; Viskochil, David H; Allen, Jeffrey C; Korf, Bruce; Cantor, Alan; Cutter, Gary; Thomas, Coretta; Perentesis, John P; Mizuno, Tomoyuki; Vinks, Alexander A; Manley, Peter E; Chi, Susan N; Kieran, Mark W (2020. ) A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study.Neuro-oncology, , 22 (10 ) ,1527-1535 More Information
Tang Girdwood, Sonya; Arbough, Trent; Dong, Min; Mizuno, Tomoyuki; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer (2020. ) Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets.Pharmacotherapy, , 40 (10 ) ,1061-1068 More Information
Somberg, John C; Vinks, Alexander A; Dong, Min; Molnar, Janos (2020. ) Model-Informed Development of Sotalol Loading and Dose Escalation Employing an Intravenous Infusion.Cardiology research, , 11 (5 ) ,294-304 More Information
Balyan, Rajiv; Dong, Min; Pilipenko, Valentina; Geisler, Kristie; Vinks, Alexander A; Chidambaran, Vidya (2020. ) Hydromorphone population pharmacokinetics in pediatric surgical patients.Paediatric anaesthesia, , 30 (10 ) ,1091-1101 More Information
Euteneuer, Joshua C; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Zhao, Junfang; Setchell, Kenneth D R; Muglia, Louis J; Vinks, Alexander A (2020. ) Model-Informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants.Therapeutic drug monitoring, , 42 (5 ) ,778-786 More Information
Taylor, Zachary L; Mizuno, Tomoyuki; Punt, Nieko C; Baskaran, Balaji; Navarro Sainz, Adriana; Shuman, William; Felicelli, Nicholas; Vinks, Alexander A; Heldrup, Jesper; Ramsey, Laura B (2020. ) MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase.Clinical pharmacology and therapeutics, , 108 (3 ) ,635-643 More Information
Hahn, David; Fukuda, Tsuyoshi; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Sadhasivam, Senthilkumar; Emoto, Chie (2020. ) Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients.Journal of clinical pharmacology, , 60 (8 ) ,992-998 More Information
Ware, Russell E; Marahatta, Anu; Ware, Julie L; McElhinney, Kathryn; Dong, Min; Vinks, Alexander A (2020. ) Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS).The Journal of pediatrics, , 222 ,236-239 More Information
van Hoogdalem, Matthijs W; Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Mehta, Parinda A; Vinks, Alexander A (2020. ) Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients.British journal of clinical pharmacology, , 86 (5 ) ,933-943 More Information
McPhail, Brooks T; Emoto, Chie; Fukuda, Tsuyoshi; Butler, Dawn; Wiles, Jason R; Akinbi, Henry; Vinks, Alexander A (2020. ) Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients.Journal of clinical pharmacology, , 60 (4 ) ,453-465 More Information
Bauman, Laura E; Xiong, Ye; Mizuno, Tomoyuki; Minar, Philip; Fukuda, Tsuyoshi; Dong, Min; Rosen, Michael J; Vinks, Alexander A (2020. ) Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease.Inflammatory bowel diseases, , 26 (3 ) ,429-439 More Information
Emoto, Chie; Hahn, David; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi (2020. ) Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates.Clinical pharmacology and therapeutics, , 107 (2 ) ,319-320 More Information
Vinks, Alexander A; Peck, Richard W; Neely, Michael; Mould, Diane R (2020. ) Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs.Clinical pharmacology and therapeutics, , 107 (1 ) ,129-135 More Information
Vinks, Alexander A; Punt, Nieko C; Menke, Frank; Kirkendall, Eric; Butler, Dawn; Duggan, Thomas J; Cortezzo, DonnaMaria E; Kiger, Sam; Dietrich, Tom; Spencer, Paul; Keefer, Rob; Setchell, Kenneth D R; Zhao, Junfang; Euteneuer, Joshua C; Mizuno, Tomoyuki; Dufendach, Kevin R (2020. ) Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates.Clinical pharmacology and therapeutics, , 107 (1 ) ,186-194 More Information
Tang Girdwood, Sonya C; Mizuno, Tomoyuki; Krallman, Kelli A; Benken, Laura A; Stoneman, Erin M; Yunger, Toni M; Wong, Hector R; Vinks, Alexander A; Kaplan, Jennifer M (2019. ) Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children.The Pediatric infectious disease journal, , 38 (12 ) ,1224-1227 More Information
Mehta, Parinda A; Emoto, Chie; Fukuda, Tsuyoshi; Seyboth, Brian; Teusink-Cross, Ashley; Davies, Stella M; Wilhelm, Jamie; Fuller, Kirsten; Vinks, Alexander A; Boulad, Farid (2019. ) Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different?.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 25 (12 ) ,2416-2421 More Information
Leino, Abbie D; Emoto, Chie; Fukuda, Tsuyoshi; Privitera, Michael; Vinks, Alexander A; Alloway, Rita R (2019. ) Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, , 19 (10 ) ,2944-2948 More Information
McGann, Patrick T; Niss, Omar; Dong, Min; Marahatta, Anu; Howard, Thad A; Mizuno, Tomoyuki; Lane, Adam; Kalfa, Theodosia A; Malik, Punam; Quinn, Charles T; Ware, Russell E; Vinks, Alexander A (2019. ) Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia.American journal of hematology, , 94 (8 ) ,871-879 More Information
Brunet, Mercè; van Gelder, Teun; Åsberg, Anders; Haufroid, Vincent; Hesselink, Dennis A; Langman, Loralie; Lemaitre, Florian; Marquet, Pierre; Seger, Christoph; Shipkova, Maria; Vinks, Alexander; Wallemacq, Pierre; Wieland, Eberhard; Woillard, Jean Baptiste; Barten, Markus J; Budde, Klemens; Colom, Helena; Dieterlen, Maja-Theresa; Elens, Laure; Johnson-Davis, Kamisha L; Kunicki, Paweł K; MacPhee, Iain; Masuda, Satohiro; Mathew, Binu S; Millán, Olga; Mizuno, Tomoyuki; Moes, Dirk-Jan A R; Monchaud, Caroline; Noceti, Ofelia; Pawinski, Tomasz; Picard, Nicolas; van Schaik, Ron; Sommerer, Claudia; Vethe, Nils Tore; de Winter, Brenda; Christians, Uwe; Bergan, Stein (2019. ) Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report.Therapeutic drug monitoring, , 41 (3 ) ,261-307 More Information
Mizuno, Tomoyuki; Gist, Katja M; Gao, Zhiqian; Wempe, Michael F; Alten, Jeffrey; Cooper, David S; Goldstein, Stuart L; Vinks, Alexander A (2019. ) Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.Clinical pharmacokinetics, , 58 (6 ) ,793-803 More Information
Soul, Janet S; Pressler, Ronit; Allen, Marilee; Boylan, Geraldine; Rabe, Heike; Portman, Ron; Hardy, Pollyanna; Zohar, Sarah; Romero, Klaus; Tseng, Brian; Bhatt-Mehta, Varsha; Hahn, Cecil; Denne, Scott; Auvin, Stephane; Vinks, Alexander; Lantos, John; Marlow, Neil; Davis, Jonathan M (2019. ) Recommendations for the design of therapeutic trials for neonatal seizures.Pediatric research, , 85 (7 ) ,943-954 More Information
Lichvar, Alicia; Tremblay, Simon; Naik, Devanshi; Lipscomb, Jessi; King, Eileen; Vinks, Alexander A; Christians, Uwe; Alloway, Rita R (2019. ) Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients.Pharmacotherapy, , 39 (5 ) ,564-575 More Information
Emoto, Chie; Johnson, Trevor N; Hahn, David; Christians, Uwe; Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi (2019. ) A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition.CPT: pharmacometrics & systems pharmacology, , 8 (5 ) ,273-284 More Information
Ramsey, Laura B; Mizuno, Tomoyuki; Vinks, Alexander A; O'Brien, Maureen M (2019. ) Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib.Pediatric blood & cancer, , 66 (5 ) ,e27618 More Information
Leino, Abbie D; King, Eileen C; Jiang, Wenlei; Vinks, Alexander A; Klawitter, Jost; Christians, Uwe; Woodle, E Steve; Alloway, Rita R; Rohan, Jennifer M (2019. ) Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, , 19 (5 ) ,1410-1420 More Information
Vinks, Alexander A (2019. ) From Molecule to Patient and Ways to Get the Dose Precisely Right.Clinical pharmacology and therapeutics, , 105 (3 ) ,534-537 More Information
Hahn, David; Emoto, Chie; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi (2019. ) Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study.Clinical pharmacology and therapeutics, , 105 (3 ) ,761-768 More Information
Mizuno, Tomoyuki; O'Brien, Maureen M; Vinks, Alexander A (2019. ) Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , 128 ,209-214 More Information
Euteneuer, Joshua C; Kamatkar, Suyog; Fukuda, Tsuyoshi; Vinks, Alexander A; Akinbi, Henry T (2019. ) Suggestions for Model-Informed Precision Dosing to Optimize Neonatal Drug Therapy.Journal of clinical pharmacology, , 59 (2 ) ,168-176 More Information
Boucher, Alexander A; Mizuno, Tomoyuki; Vinks, Alexander A; Goldstein, Stuart L; Tiao, Greg M; Geller, James I (2019. ) Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma.Pediatric blood & cancer, , 66 (1 ) ,e27425 More Information
Ramsey, Laura B; Prows, Cynthia A; Zhang, Kejian; Saldaña, Shannon N; Sorter, Michael T; Pestian, John P; Wenstrup, Richard J; Vinks, Alexander A; Glauser, Tracy A (2019. ) Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine.Clinical pharmacology and therapeutics, , 105 (1 ) ,49-52 More Information
Kaplan, Jennifer M; Zingarelli, Basilia; Krallman, Kelli; Tang Girdwood, Sonya; Lagory, Denise; Mizuno, Tomoyuki; Fei, Lin; Wong, Hector R; Vinks, Alexander A (2018. ) Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial.Intensive care medicine, , 44 (11 ) ,2006-2008 More Information
Berry, Susan A; Vockley, Jerry; Vinks, Alexander A; Dong, Min; Diaz, George A; McCandless, Shawn E; Smith, Wendy E; Harding, Cary O; Zori, Roberto; Ficicioglu, Can; Lichter-Konecki, Uta; Perdok, Renee; Robinson, Beth; Holt, Robert J; Longo, Nicola (2018. ) Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders.Molecular genetics and metabolism, , 125 (3 ) ,251-257 More Information
Emoto, Chie; Johnson, Trevor N; Neuhoff, Sibylle; Hahn, David; Vinks, Alexander A; Fukuda, Tsuyoshi (2018. ) PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants.CPT: pharmacometrics & systems pharmacology, , 7 (7 ) ,464-473 More Information
Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A (2018. ) Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management.British journal of clinical pharmacology, , 84 (7 ) ,1410-1412 More Information
Chandra, Sharat; Fukuda, Tsuyoshi; Mizuno, Kana; Davies, Stella M; Teusink-Cross, Ashley; Tarin, Rich; Marsh, Rebecca A; Vinks, Alexander A; Mehta, Parinda A (2018. ) Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study.The Journal of antimicrobial chemotherapy, , 73 (6 ) ,1651-1658 More Information
Miller, J W; Balyan, R; Dong, M; Mahmoud, M; Lam, J E; Pratap, J N; Paquin, J R; Li, B L; Spaeth, J P; Vinks, A; Loepke, A W (2018. ) Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study.British journal of anaesthesia, , 120 (5 ) ,1056-1065 More Information
Mizuno, Kana; Dong, Min; Fukuda, Tsuyoshi; Chandra, Sharat; Mehta, Parinda A; McConnell, Scott; Anaissie, Elias J; Vinks, Alexander A (2018. ) Population Pharmacokinetics and Optimal Sampling Strategy for Model-Based Precision Dosing of Melphalan in Patients Undergoing Hematopoietic Stem Cell Transplantation.Clinical pharmacokinetics, , 57 (5 ) ,625-636 More Information
Gist, Katja M; Cooper, David S; Wrona, Julia; Faubel, Sarah; Altmann, Christopher; Gao, Zhiqian; Marino, Bradley S; Alten, Jeffrey; Hock, Kristal M; Mizuno, Tomoyuki; Vinks, Alexander A; Joy, Melanie S; Wempe, Michael F; Bennett, Michael R; Goldstein, Stuart L (2018. ) Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery.Therapeutic drug monitoring, , 40 (2 ) ,186-194 More Information
Emoto, Chie; Johnson, Trevor N; McPhail, Brooks T; Vinks, Alexander A; Fukuda, Tsuyoshi (2018. ) Using a Vancomycin PBPK Model in Special Populations to Elucidate Case-Based Clinical PK Observations.CPT: pharmacometrics & systems pharmacology, , 7 (4 ) ,237-250 More Information
Ramsey, Laura B; Balis, Frank M; O'Brien, Maureen M; Schmiegelow, Kjeld; Pauley, Jennifer L; Bleyer, Archie; Widemann, Brigitte C; Askenazi, David; Bergeron, Sharon; Shirali, Anushree; Schwartz, Stefan; Vinks, Alexander A; Heldrup, Jesper (2018. ) Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.The oncologist, , 23 (1 ) ,52-61 More Information
Xiong, Ye; Fukuda, Tsuyoshi; Knibbe, Catherijne A J; Vinks, Alexander A (2017. ) Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies.Pediatric clinics of North America, , 64 (6 ) ,1417-1438 More Information
Cabrera-Salcedo, Catalina; Mizuno, Tomoyuki; Tyzinski, Leah; Andrew, Melissa; Vinks, Alexander A; Frystyk, Jan; Wasserman, Halley; Gordon, Catherine M; Hwa, Vivian; Backeljauw, Philippe; Dauber, Andrew (2017. ) Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density.The Journal of clinical endocrinology and metabolism, , 102 (12 ) ,4568-4577 More Information
Mizuno, Tomoyuki; Emoto, Chie; Fukuda, Tsuyoshi; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A (2017. ) Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , 109S ,S124-S131 More Information
Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; King, Eileen C; Zou, Yuanshu; Jiang, Wenlei; Woodle, E Steve; Tremblay, Simon; Klawitter, Jelena; Klawitter, Jost; Christians, Uwe (2017. ) Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial.PLoS medicine, , 14 (11 ) ,e1002428 More Information
Varnell, Charles D; Fukuda, Tsuyoshi; Kirby, Cassie L; Martin, Lisa J; Warshaw, Barry L; Patel, Hiren P; Chand, Deepa H; Barletta, Gina-Marie; Van Why, Scott K; VanDeVoorde, Rene G; Weaver, Donald J; Wilson, Amy; Verghese, Priya S; Vinks, Alexander A; Greenbaum, Larry A; Goebel, Jens; Hooper, David K (2017. ) Mycophenolate mofetil-related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs.Pediatric transplantation, , 21 (7 ) , More Information
Faircloth, Jenna M; Roe, Olivia; Alsaied, Tarek; Palumbo, Joseph S; Vinks, Alexander; Veldtman, Gruschen R (2017. ) Intermediate term thrombotic risk in contemporary total cavo-pulmonary connection for single ventricle circulations.Journal of thrombosis and thrombolysis, , 44 (3 ) ,275-280 More Information
Selim, Sally; Riesenberg, Robert; Cassella, James; Kunta, Jeevan; Hellriegel, Edward; Smith, Mark A; Vinks, Alexander A; Rabinovich-Guilatt, Laura (2017. ) Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents.Journal of clinical pharmacology, , 57 (10 ) ,1244-1257 More Information
Dong, Min; Fukuda, Tsuyoshi; Selim, Sally; Smith, Mark A; Rabinovich-Guilatt, Laura; Cassella, James V; Vinks, Alexander A (2017. ) Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents.Clinical pharmacokinetics, , 56 (10 ) ,1207-1217 More Information
Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A (2017. ) Opportunities for model-based precision dosing in the treatment of sickle cell anemia.Blood cells, molecules & diseases, , 67 ,143-147 More Information
Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Emoto, Chie; Mobberley-Schuman, Paula S; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A (2017. ) Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies.Pediatric blood & cancer, , 64 (8 ) , More Information
Faircloth, Jenna M; Miner, Kristin M; Alsaied, Tarek; Nelson, Nicole; Ciambarella, Julie; Mizuno, Tomoyuki; Palumbo, Joseph S; Vinks, Alexander A; Veldtman, Gruschen R (2017. ) Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients.Journal of thrombosis and thrombolysis, , 44 (1 ) ,38-47 More Information
Diwan, Tayyab S; Lichvar, Alicia B; Leino, Abbie D; Vinks, Alexander A; Christians, Uwe; Shields, Adele R; Cardi, Michael A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Kaiser, Tiffany; Woodle, E Steve; Alloway, Rita R (2017. ) Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy.Clinical transplantation, , 31 (6 ) , More Information
Balyan, Rajiv; Zhang, Xue; Chidambaran, Vidya; Martin, Lisa J; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Vinks, Alexander A; Sadhasivam, Senthilkumar (2017. ) OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children.Pharmacogenomics, , 18 (7 ) ,621-629 More Information
Darwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; Reny, J-L; Marsousi, N; Daali, Y; Fairman, D; Cook, J; Lesko, L J; McCune, J S; Knibbe, Caj; de Wildt, S N; Leeder, J S; Neely, M; Zuppa, A F; Vicini, P; Aarons, L; Johnson, T N; Boiani, J; Rostami-Hodjegan, A (2017. ) Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.Clinical pharmacology and therapeutics, , 101 (5 ) ,646-656 More Information
Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Christians, Uwe; Perentesis, John P; Fouladi, Maryam; Vinks, Alexander A (2017. ) Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group.British journal of clinical pharmacology, , 83 (5 ) ,1097-1107 More Information
Marsh, Rebecca A; Fukuda, Tsuyoshi; Emoto, Chie; Neumeier, Lisa; Khandelwal, Pooja; Chandra, Sharat; Teusink-Cross, Ashley; Vinks, Alexander A; Mehta, Parinda A (2017. ) Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 23 (4 ) ,635-641 More Information
Balyan, Rajiv; Mecoli, Marc; Venkatasubramanian, Raja; Chidambaran, Vidya; Kamos, Nichole; Clay, Smokey; Moore, David L; Mavi, Jagroop; Glover, Chris D; Szmuk, Peter; Vinks, Alexander; Sadhasivam, Senthilkumar (2017. ) CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients.Pharmacogenomics, , 18 (4 ) ,337-348 More Information
Vinks, A A (2017. ) Precision Medicine-Nobody Is Average.Clinical pharmacology and therapeutics, , 101 (3 ) ,304-307 More Information
Ramsey, L B; Mizuno, T; Vinks, A A; Margolis, P A (2017. ) Learning Health Systems as Facilitators of Precision Medicine.Clinical pharmacology and therapeutics, , 101 (3 ) ,359-367 More Information
Rohan, Jennifer M; Fukuda, Tsuyoshi; Alderfer, Melissa A; Wetherington Donewar, Crista; Ewing, Linda; Katz, Ernest R; Muriel, Anna C; Vinks, Alexander A; Drotar, Dennis (2017. ) Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation.Journal of pediatric psychology, , 42 (2 ) ,232-244 More Information
Chidambaran, V; Venkatasubramanian, R; Zhang, X; Martin, L J; Niu, J; Mizuno, T; Fukuda, T; Meller, J; Vinks, A A; Sadhasivam, S (2017. ) ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.The pharmacogenomics journal, , 17 (2 ) ,162-169 More Information
Emoto, C; Fukuda, T; Johnson, T N; Neuhoff, S; Sadhasivam, S; Vinks, A A (2017. ) Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.CPT: pharmacometrics & systems pharmacology, , 6 (2 ) ,110-119 More Information
Yu, Tian; Enioutina, Elena Y; Brunner, Hermine I; Vinks, Alexander A; Sherwin, Catherine M (2017. ) Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus.Clinical pharmacokinetics, , 56 (2 ) ,107-125 More Information
Chidambaran, Vidya; Pilipenko, Valentina; Spruance, Kristie; Venkatasubramanian, Raja; Niu, Jing; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Zhang, Kejian; Kaufman, Kenneth; Vinks, Alexander A; Martin, Lisa J; Sadhasivam, Senthilkumar (2017. ) Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.Pharmacogenomics, , 18 (2 ) ,143-156 More Information
Hahn, David; Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi (2017. ) Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.Drug metabolism and disposition: the biological fate of chemicals, , 45 (1 ) ,23-26 More Information
Downes, Kevin J; Dong, Min; Fukuda, Tsuyoshi; Clancy, John P; Haffner, Christopher; Bennett, Michael R; Vinks, Alexander A; Goldstein, Stuart L (2017. ) Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis.The Journal of antimicrobial chemotherapy, , 72 (1 ) ,254-260 More Information
Khandelwal, Pooja; Emoto, Chie; Fukuda, Tsuyoshi; Vinks, Alexander A; Neumeier, Lisa; Dandoy, Christopher E; El-Bietar, Javier; Chandra, Sharat; Davies, Stella M; Bleesing, Jacob J; Jordan, Michael B; Mehta, Parinda A; Jodele, Sonata; Grimley, Michael S; Kumar, Ashish; Myers, Kasiani C; Marsh, Rebecca A (2016. ) A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 22 (12 ) ,2220-2225 More Information
Khandelwal, Pooja; Fukuda, Tsuyoshi; Mizuno, Kana; Teusink-Cross, Ashley; Mehta, Parinda A; Marsh, Rebecca A; Kashuba, Angela D M; Vinks, Alexander A; Davies, Stella M (2016. ) A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 22 (10 ) ,1829-1835 More Information
Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi (2016. ) Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients.Therapeutic drug monitoring, , 38 (5 ) ,607-13 More Information
Emoto, C; Fukuda, T; Mizuno, T; Schniedewind, B; Christians, Uwe; Adams, D M; Vinks, A A (2016. ) Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants.CPT: pharmacometrics & systems pharmacology, , 5 (8 ) ,411-7 More Information
Cvijanovich, Natalie Z; King, Janet C; Flori, Heidi R; Gildengorin, Ginny; Vinks, Alexander A; Wong, Hector R (2016. ) Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness.JPEN. Journal of parenteral and enteral nutrition, , 40 (6 ) ,860-8 More Information
Arya, Ravindra; Gillespie, Catherine W; Cnaan, Avital; Devarajan, Mahima; Clark, Peggy; Shinnar, Shlomo; Vinks, Alexander A; Mizuno, Kana; Glauser, Tracy A (2016. ) Obesity and overweight as CAE comorbidities and differential drug response modifiers.Neurology, , 86 (17 ) ,1613-21 More Information
Hahn, Andrea; Fukuda, Tsuyoshi; Hahn, David; Mizuno, Tomoyuki; Frenck, Robert W; Vinks, Alexander A (2016. ) Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia.Pharmacogenomics, , 17 (6 ) ,547-59 More Information
Vinks, Alexander A (2016. ) Therapeutic Optimization as Part of the Precision Medicine Paradigm.Clinical pharmacology and therapeutics, , 99 (4 ) ,340-2 More Information
Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A (2016. ) Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1-Erratum.Therapeutic drug monitoring, , 38 (2 ) ,284 More Information
Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A (2016. ) Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia.British journal of clinical pharmacology, , 81 (4 ) ,742-52 More Information
Downes, Kevin J; Goldstein, Stuart L; Vinks, Alexander A (2016. ) Increased Vancomycin Exposure and Nephrotoxicity in Children: Therapeutic Does Not Mean Safe.Journal of the Pediatric Infectious Diseases Society, , 5 (1 ) ,65-7 More Information
Teusink, Ashley; Vinks, Alexander; Zhang, Kejian; Davies, Stella; Fukuda, Tsuyoshi; Lane, Adam; Nortman, Shannon; Kissell, Diane; Dell, Sarah; Filipovich, Alexandra; Mehta, Parinda (2016. ) Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 22 (3 ) ,482-6 More Information
Nehus, Edward J; Mizuno, Tomoyuki; Cox, Shareen; Goldstein, Stuart L; Vinks, Alexander A (2016. ) Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations.Journal of clinical pharmacology, , 56 (3 ) ,291-7 More Information
Adams, Denise M; Trenor, Cameron C; Hammill, Adrienne M; Vinks, Alexander A; Patel, Manish N; Chaudry, Gulraiz; Wentzel, Mary Sue; Mobberley-Schuman, Paula S; Campbell, Lisa M; Brookbank, Christine; Gupta, Anita; Chute, Carol; Eile, Jennifer; McKenna, Jesse; Merrow, Arnold C; Fei, Lin; Hornung, Lindsey; Seid, Michael; Dasgupta, A Roshni; Dickie, Belinda H; Elluru, Ravindhra G; Lucky, Anne W; Weiss, Brian; Azizkhan, Richard G (2016. ) Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies.Pediatrics, , 137 (2 ) ,e20153257 More Information
Jodele, Sonata; Fukuda, Tsuyoshi; Mizuno, Kana; Vinks, Alexander A; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Chima, Ranjit S; Hirsch, Russel; Teusink, Ashley; Lazear, Danielle; Lane, Adam; Myers, Kasiani C; Dandoy, Christopher E; Davies, Stella M (2016. ) Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 22 (2 ) ,307-315 More Information
Gist, Katja M; Goldstein, Stuart L; Joy, Melanie S; Vinks, Alexander A (2016. ) Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review.Journal of cardiovascular pharmacology, , 67 (2 ) ,175-81 More Information
Ngamprasertwong, Pornswan; Dong, Min; Niu, Jing; Venkatasubramanian, Raja; Vinks, Alexander A; Sadhasivam, Senthilkumar (2016. ) Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model.PloS one, , 11 (1 ) ,e0146563 More Information
Wiles, Jason R; Isemann, Barbara; Mizuno, Tomoyuki; Tabangin, Meredith E; Ward, Laura P; Akinbi, Henry; Vinks, Alexander A (2015. ) Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study.The Journal of pediatrics, , 167 (6 ) ,1214-20.e3 More Information
Christians, Uwe; Vinks, Alexander A; Langman, Loralie J; Clarke, William; Wallemacq, Pierre; van Gelder, Teun; Renjen, Varun; Marquet, Pierre; Meyer, Eric J (2015. ) Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs.Therapeutic drug monitoring, , 37 (6 ) ,718-24 More Information
Emoto, Chie; Fukuda, Tsuyoshi; Venkatasubramanian, Raja; Vinks, Alexander A (2015. ) The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model.British journal of clinical pharmacology, , 80 (6 ) ,1438-46 More Information
Gist, Katja M; Mizuno, Tomoyuki; Goldstein, Stuart L; Vinks, Alexander (2015. ) Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury.Therapeutic drug monitoring, , 37 (6 ) ,792-6 More Information
Shokati, Touraj; Bodenberger, Nicholas; Gadpaille, Holly; Schniedewind, Björn; Vinks, Alexander A; Jiang, Wenlei; Alloway, Rita R; Christians, Uwe (2015. ) Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS.Journal of visualized experiments : JoVE, , (105 ) ,e52424 More Information
Hahn, Andrea; Frenck, Robert W; Allen-Staat, Mary; Zou, Yuanshu; Vinks, Alexander A (2015. ) Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia.Therapeutic drug monitoring, , 37 (5 ) ,619-25 More Information
Shinnar, Shlomo; Cnaan, Avital; Hu, Fengming; Clark, Peggy; Dlugos, Dennis; Hirtz, Deborah G; Masur, David; Mizrahi, Eli M; Moshé, Solomon L; Glauser, Tracy A (2015. ) Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial.Neurology, , 85 (13 ) ,1108-14 More Information
Vinks, A A; Emoto, C; Fukuda, T (2015. ) Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children.Clinical pharmacology and therapeutics, , 98 (3 ) ,298-308 More Information
Chidambaran, Vidya; Venkatasubramanian, Raja; Sadhasivam, Senthilkumar; Esslinger, Hope; Cox, Shareen; Diepstraten, Jeroen; Fukuda, Tsuyoshi; Inge, Thomas; Knibbe, Catherijne A J; Vinks, Alexander A (2015. ) Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.Paediatric anaesthesia, , 25 (9 ) ,911-923 More Information
Rosen, M J; Minar, P; Vinks, A A (2015. ) Letter: stool adalimumab detection in ulcerative colitis and Crohn's disease--authors' reply.Alimentary pharmacology & therapeutics, , 42 (2 ) ,241 More Information
Birdwell, K A; Decker, B; Barbarino, J M; Peterson, J F; Stein, C M; Sadee, W; Wang, D; Vinks, A A; He, Y; Swen, J J; Leeder, J S; van Schaik, Rhn; Thummel, K E; Klein, T E; Caudle, K E; MacPhee, I A M (2015. ) Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.Clinical pharmacology and therapeutics, , 98 (1 ) ,19-24 More Information
Rosen, M J; Minar, P; Vinks, A A (2015. ) Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis.Alimentary pharmacology & therapeutics, , 41 (11 ) ,1094-103 More Information
Hahn, Andrea; Frenck, Robert W; Zou, Yuanshu; Vinks, Alexander A (2015. ) Validation of a pediatric population pharmacokinetic model for vancomycin.Therapeutic drug monitoring, , 37 (3 ) ,413-6 More Information
Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Cox, Shareen; Schniedewind, Björn; Christians, Uwe; Widemann, Brigitte C; Fisher, Michael J; Weiss, Brian; Perentesis, John; Vinks, Alexander A (2015. ) Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.Therapeutic drug monitoring, , 37 (3 ) ,395-9 More Information
Fouladi, Maryam; Perentesis, John P; Wagner, Lars M; Vinks, Alexander A; Reid, Joel M; Ahern, Charlotte; Thomas, George; Mercer, Carol A; Krueger, Darcy A; Houghton, Peter J; Doyle, L Austin; Chen, Helen; Weigel, Brenda; Blaney, Susan M (2015. ) A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report.Clinical cancer research : an official journal of the American Association for Cancer Research, , 21 (7 ) ,1558-65 More Information
Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander; Cantor, Alan; Perentesis, John; Schorry, Elizabeth; Ullrich, Nicole; Gutmann, David H; Tonsgard, James; Viskochil, David; Korf, Bruce; Packer, Roger J; Fisher, Michael J (2015. ) Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study.Neuro-oncology, , 17 (4 ) ,596-603 More Information
Emoto, C; Fukuda, T; Johnson, T N; Adams, D M; Vinks, A A (2015. ) Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants.CPT: pharmacometrics & systems pharmacology, , 4 (2 ) ,e17 More Information
Nehus, Edward J; Mouksassi, Samer; Vinks, Alexander A; Goldstein, Stuart (2014. ) Meropenem in children receiving continuous renal replacement therapy: clinical trial simulations using realistic covariates.Journal of clinical pharmacology, , 54 (12 ) ,1421-8 More Information
Smits, Thomas A; Cox, Shareen; Fukuda, Tsuyoshi; Sherbotie, Joseph R; Ward, Robert M; Goebel, Jens; Vinks, Alexander A (2014. ) Effects of unbound mycophenolic acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients.Therapeutic drug monitoring, , 36 (6 ) ,716-23 More Information
Dong, Min; Fukuda, Tsuyoshi; Cox, Shareen; de Vries, Marij T; Hooper, David K; Goebel, Jens; Vinks, Alexander A (2014. ) Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period.British journal of clinical pharmacology, , 78 (5 ) ,1102-12 More Information
Rasmussen-Torvik, L J; Stallings, S C; Gordon, A S; Almoguera, B; Basford, M A; Bielinski, S J; Brautbar, A; Brilliant, M H; Carrell, D S; Connolly, J J; Crosslin, D R; Doheny, K F; Gallego, C J; Gottesman, O; Kim, D S; Leppig, K A; Li, R; Lin, S; Manzi, S; Mejia, A R; Pacheco, J A; Pan, V; Pathak, J; Perry, C L; Peterson, J F; Prows, C A; Ralston, J; Rasmussen, L V; Ritchie, M D; Sadhasivam, S; Scott, S A; Smith, M; Vega, A; Vinks, A A; Volpi, S; Wolf, W A; Bottinger, E; Chisholm, R L; Chute, C G; Haines, J L; Harley, J B; Keating, B; Holm, I A; Kullo, I J; Jarvik, G P; Larson, E B; Manolio, T; McCarty, C A; Nickerson, D A; Scherer, S E; Williams, M S; Roden, D M; Denny, J C (2014. ) Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.Clinical pharmacology and therapeutics, , 96 (4 ) ,482-9 More Information
Wiles, Jason R; Isemann, Barbara; Ward, Laura P; Vinks, Alexander A; Akinbi, Henry (2014. ) Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure.The Journal of pediatrics, , 165 (3 ) ,440-6 More Information
Venkatasubramanian, Raja; Fukuda, Tsuyoshi; Niu, Jing; Mizuno, Tomoyuki; Chidambaran, Vidya; Vinks, Alexander A; Sadhasivam, Senthilkumar (2014. ) ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.Pharmacogenomics, , 15 (10 ) ,1297-309 More Information
Jarvik, Gail P; Amendola, Laura M; Berg, Jonathan S; Brothers, Kyle; Clayton, Ellen W; Chung, Wendy; Evans, Barbara J; Evans, James P; Fullerton, Stephanie M; Gallego, Carlos J; Garrison, Nanibaa' A; Gray, Stacy W; Holm, Ingrid A; Kullo, Iftikhar J; Lehmann, Lisa Soleymani; McCarty, Cathy; Prows, Cynthia A; Rehm, Heidi L; Sharp, Richard R; Salama, Joseph; Sanderson, Saskia; Van Driest, Sara L; Williams, Marc S; Wolf, Susan M; Wolf, Wendy A ; Burke, Wylie (2014. ) Return of genomic results to research participants: the floor, the ceiling, and the choices in between.American journal of human genetics, , 94 (6 ) ,818-26 More Information
Mizuno, Tomoyuki; Fukudo, Masahide; Fukuda, Tsuyoshi; Terada, Tomohiro; Dong, Min; Kamba, Tomomi; Yamasaki, Toshinari; Ogawa, Osamu; Katsura, Toshiya; Inui, Ken-Ichi; Vinks, Alexander A; Matsubara, Kazuo (2014. ) The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma.Therapeutic drug monitoring, , 36 (3 ) ,310-6 More Information
Roberts, Jason A; Abdul-Aziz, Mohd H; Lipman, Jeffrey; Mouton, Johan W; Vinks, Alexander A; Felton, Timothy W; Hope, William W; Farkas, Andras; Neely, Michael N; Schentag, Jerome J; Drusano, George; Frey, Otto R; Theuretzbacher, Ursula; Kuti, Joseph L (2014. ) Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.The Lancet. Infectious diseases, , 14 (6 ) ,498-509 More Information
Filler, Guido; Vinks, Alexander A; Huang, Shih-Han S; Jevnikar, Anthony; Muirhead, Norman (2014. ) Similar MPA exposure on modified release and regular tacrolimus.Therapeutic drug monitoring, , 36 (3 ) ,353-7 More Information
Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Masuda, Satohiro; Uemoto, Shinji; Matsubara, Kazuo; Inui, Ken-Ichi; Vinks, Alexander A (2014. ) Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children.British journal of clinical pharmacology, , 77 (5 ) ,910-2 More Information
Jodele, Sonata; Fukuda, Tsuyoshi; Vinks, Alexander; Mizuno, Kana; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Teusink, Ashley; Pluthero, Fred G; Lu, Lily; Licht, Christoph; Davies, Stella M (2014. ) Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 20 (4 ) ,518-25 More Information
Downes, Kevin J; Hahn, Andrea; Wiles, Jason; Courter, Joshua D; Vinks, Alexander A (2014. ) Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics.International journal of antimicrobial agents, , 43 (3 ) ,223-30 More Information
Sherwin, Catherine M T; Ngamprasertwong, Pornswan; Sadhasivam, Senthilkumar; Vinks, Alexander A (2014. ) Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study.Current clinical pharmacology, , 9 (1 ) ,64-9 More Information
Dong, Min; Fukuda, Tsuyoshi; Vinks, Alexander A (2014. ) Optimization of mycophenolic acid therapy using clinical pharmacometrics.Drug metabolism and pharmacokinetics, , 29 (1 ) ,4-11 More Information
Hahn, Andrea; Vinks, Alexander A (2013. ) Lower vancomycin serum trough concentrations might not be the answer.The Pediatric infectious disease journal, , 32 (12 ) ,1403-4 More Information
Emoto, C; Fukuda, T; Cox, S; Christians, U; Vinks, A A (2013. ) Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content.CPT: pharmacometrics & systems pharmacology, , 2 (7 ) ,e59 More Information
Fukuda, Tsuyoshi; Chidambaran, Vidya; Mizuno, Tomoyuki; Venkatasubramanian, Raja; Ngamprasertwong, Pornswan; Olbrecht, Vanessa; Esslinger, Hope R; Vinks, Alexander A; Sadhasivam, Senthilkumar (2013. ) OCT1 genetic variants influence the pharmacokinetics of morphine in children.Pharmacogenomics, , 14 (10 ) ,1141-51 More Information
Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A (2013. ) Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1.Therapeutic drug monitoring, , 35 (3 ) ,332-7 More Information
Chidambaran, Vidya; Sadhasivam, Senthilkumar; Diepstraten, Jeroen; Esslinger, Hope; Cox, Shareen; Schnell, Beverly M; Samuels, Paul; Inge, Thomas; Vinks, Alexander A; Knibbe, Catherijne A (2013. ) Evaluation of propofol anesthesia in morbidly obese children and adolescents.BMC anesthesiology, , 13 ,8 More Information
Vinks, A A (2013. ) The future of physiologically based pharmacokinetic modeling to predict drug exposure in pregnant women.CPT: pharmacometrics & systems pharmacology, , 2 (3 ) ,e33 More Information
Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Adamson, Peter C (2013. ) Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months.Epilepsia, , 54 (1 ) ,141-55 More Information
Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A (2012. ) Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size.Clinical pharmacokinetics, , 51 (8 ) ,543-551 More Information
Farag, Elmoubasher; Sikkema, Reina S; Vinks, Tinka; Islam, Md Mazharul; Nour, Mohamed; Al-Romaihi, Hamad; Al Thani, Mohammed; Atta, Muzzamil; Alhajri, Farhoud H; Al-Marri, Salih; AlHajri, Mohd; Reusken, Chantal; Koopmans, Marion (2018. ) Drivers of MERS-CoV Emergence in Qatar.Viruses, , 11 (1 ) , More Information
Brouwer, K L R; Aleksunes, L M; Brandys, B; Giacoia, G P; Knipp, G; Lukacova, V; Meibohm, B; Nigam, S K; Rieder, M; de Wildt, S N (2015. ) Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.Clinical pharmacology and therapeutics, , 98 (3 ) ,266-87 More Information
Yang, Xiaoyan; Sherwin, Catherine M T; Yu, Tian; Yellepeddi, Venkata K; Brunner, Hermine I; Vinks, Alexander A (2015. ) Pharmacokinetic modeling of therapies for systemic lupus erythematosus.Expert review of clinical pharmacology, , 8 (5 ) ,587-603 More Information
Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander A; Cantor, Alan; Korf, Bruce; Perentesis, John; Gutmann, David H; Schorry, Elizabeth; Packer, Roger; Fisher, Michael J (2014. ) Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study.Pediatric blood & cancer, , 61 (6 ) ,982-6 More Information
Pian, Phillip; Labovitz, Edward; Hoffman, Keith; Clavijo, Claudia F; Rzasa Lynn, Rachael; Galinkin, Jeffrey L; Vinks, Alexander A; Malik, Punam; Christians, Uwe (2013. ) Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , 937 ,79-83 More Information
Gottesman, Omri; Kuivaniemi, Helena; Tromp, Gerard; Faucett, W Andrew; Li, Rongling; Manolio, Teri A; Sanderson, Saskia C; Kannry, Joseph; Zinberg, Randi; Basford, Melissa A; Brilliant, Murray; Carey, David J; Chisholm, Rex L; Chute, Christopher G; Connolly, John J; Crosslin, David; Denny, Joshua C; Gallego, Carlos J; Haines, Jonathan L; Hakonarson, Hakon; Harley, John; Jarvik, Gail P; Kohane, Isaac; Kullo, Iftikhar J; Larson, Eric B; McCarty, Catherine; Ritchie, Marylyn D; Roden, Dan M; Smith, Maureen E; Böttinger, Erwin P; Williams, Marc S (2013. ) The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future.Genetics in medicine : official journal of the American College of Medical Genetics, , 15 (10 ) ,761-71 More Information
Diepstraten, J; Chidambaran, V; Sadhasivam, S; Blussé van Oud-Alblas, H J; Inge, T; van Ramshorst, B; van Dongen, E P A; Vinks, A A; Knibbe, C A J (2013. ) An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children.CPT: pharmacometrics & systems pharmacology, , 2 (9 ) ,e73 More Information
Wang, Chenguang; Sadhavisvam, Senthilkumar; Krekels, Elke H J; Dahan, Albert; Tibboel, Dick; Danhof, Meindert; Vinks, Alexander A; Knibbe, Catherijne A J (2013. ) Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model.Clinical drug investigation, , 33 (7 ) ,523-34 More Information
Abdel-Rahman, Susan M; Amidon, Gordon L; Kaul, Ajay; Lukacova, Viera; Vinks, Alexander A; Knipp, Gregory T (2012. ) Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group.Clinical therapeutics, , 34 (11 ) ,S11-24 More Information
Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A (2012. ) Propofol clearance in morbidly obese children and adolescents: influence of age and body size.Clinical pharmacokinetics, , 51 (8 ) ,543-51 More Information
Cohen, Mindy; Sadhasivam, Senthilkumar; Vinks, Alexander A (2012. ) Pharmacogenetics in perioperative medicine.Current opinion in anaesthesiology, , 25 (4 ) ,419-27 More Information
Cattaneo, Dario; Vinks, Alexander A (2012. ) Optimizing immunosuppressive drug dosing in pediatric renal transplantation. Part of a special series on Paediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.Pharmacological research, , 65 (2 ) ,163-7 More Information
Vinks, Alexander A (2011. ) Important role of population pharmacokinetic/pharmacodynamic modeling in pediatric therapeutics.The Journal of pediatrics, , 159 (3 ) ,361-3 More Information
Li, Zhiping; Wang, Li; Wang, Yi; Gui, Yonghao H; Vinks, Alexander A; MacLeod, Stuart (2011. ) Better medicines for 300 million children in China: report on recent progress.Paediatric drugs, , 13 (3 ) ,137-40 More Information
Tönshoff, Burkhard; David-Neto, Elias; Ettenger, Robert; Filler, Guido; van Gelder, Teun; Goebel, Jens; Kuypers, Dirk R J; Tsai, Eileen; Vinks, Alexander A; Weber, Lutz T; Zimmerhackl, Lothar Bernd (2011. ) Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation.Transplantation reviews (Orlando, Fla.), , 25 (2 ) ,78-89 More Information
Tett, Susan E; Saint-Marcoux, Franck; Staatz, Christine E; Brunet, Merce; Vinks, Alexander A; Miura, Masatomo; Marquet, Pierre; Kuypers, Dirk R; van Gelder, Teun; Cattaneo, Dario (2011. ) Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure.Transplantation reviews (Orlando, Fla.), , 25 (2 ) ,47-57 More Information
Brandhorst, Gunnar; Oellerich, Michael; Brunet, Mercè; Kowalski, Richard; Vinks, Alexander; Wallemacq, Pierre (2011. ) Individually tailored immunosuppression: is there a role for biomarkers?.Clinical chemistry, , 57 (3 ) ,376-81 More Information
Soldin, Offie P; Soldin, Steven J; Vinks, Alexander A; Younis, Islam; Landy, Helain J (2010. ) Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope study.Therapeutic drug monitoring, , 32 (6 ) ,767-73 More Information
Kuypers, Dirk R J; Le Meur, Yannick; Cantarovich, Marcelo; Tredger, Michael J; Tett, Susan E; Cattaneo, Dario; Tönshoff, Burkhard; Holt, David W; Chapman, Jeremy; Gelder, Teun van (2010. ) Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation.Clinical journal of the American Society of Nephrology : CJASN, , 5 (2 ) ,341-58 More Information
Mouksassi, M S; Marier, J F; Cyran, J; Vinks, A A (2009. ) Clinical trial simulations in pediatric patients using realistic covariates: application to teduglutide, a glucagon-like peptide-2 analog in neonates and infants with short-bowel syndrome.Clinical pharmacology and therapeutics, , 86 (6 ) ,667-71 More Information
Thompson, Patrick A; Allen, Carl E; Horton, Terzah; Jones, Jeremy Y; Vinks, Alexander A; McClain, Kenneth L (2009. ) Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis.Pediatric blood & cancer, , 52 (5 ) ,621-5 More Information
Mouton, Johan W; Vinks, Alexander A (2007. ) Continuous infusion of beta-lactams.Current opinion in critical care, , 13 (5 ) ,598-606 More Information
Mouton, Johan W; Punt, Nieko; Vinks, Alexander A (2007. ) Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo.Antimicrobial agents and chemotherapy, , 51 (9 ) ,3449-51 More Information
Aman, Michael G; Vinks, Alexander A; Remmerie, Bart; Mannaert, Erik; Ramadan, Yaser; Masty, Jessica; Lindsay, Ronald L; Malone, Krista (2007. ) Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders.Clinical therapeutics, , 29 (7 ) ,1476-86 More Information
Syed, Azeem; Vinks, Alexander A; Zakowski, Jack (2007. ) Trend in therapeutic monitoring of immunosuppressive drugs. MLO: medical laboratory observer, , 39 (7 ) ,31-2
Weimert, Nicole A; Derotte, Maurits; Alloway, Rita R; Woodle, E Steve; Vinks, Alexander A (2007. ) Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications.Therapeutic drug monitoring, , 29 (2 ) ,141-9 More Information
Mouton, Johan W; Punt, Nieko; Vinks, Alexander A (2005. ) A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit.Clinical therapeutics, , 27 (6 ) ,762-72 More Information
Carlsson, Kristin Cecilie; Hoem, Nils Ove; Glauser, Tracy; Vinks, Alexander A (2005. ) Development of a population pharmacokinetic model for carbamazepine based on sparse therapeutic monitoring data from pediatric patients with epilepsy.Clinical therapeutics, , 27 (5 ) ,618-26 More Information
de Wildt, Saskia N; de Hoog, Matthijs; Vinks, Alexander A; Joosten, Koen F M; van Dijk, Monique; van den Anker, John N (2005. ) Pharmacodynamics of midazolam in pediatric intensive care patients.Therapeutic drug monitoring, , 27 (1 ) ,98-102 More Information
Touw, D J; Neef, C; Thomson, A H; Vinks, A A (2005. ) Cost-effectiveness of therapeutic drug monitoring: a systematic review.Therapeutic drug monitoring, , 27 (1 ) ,10-7 More Information
Mouton, Johan W; Vinks, Alexander A (2005. ) Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations.Clinical pharmacokinetics, , 44 (7 ) ,767-8 More Information
Mouton, Johan W; Vinks, Alexander A (2005. ) Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration.Clinical pharmacokinetics, , 44 (2 ) ,201-10 More Information
Bos, A M E; Boom, K; Vinks, A A; Boezen, H M; Wanders, J; Dombernovsky, P; Aamdal, S; de Vries, E G E; Uges, D R A (2004. ) Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755.Cancer chemotherapy and pharmacology, , 54 (1 ) ,64-70 More Information
Sallee, Floyd R; Gilbert, Donald L; Vinks, Alexander A; Miceli, Jeffrey J; Robarge, Lisa; Wilner, Keith (2003. ) Pharmacodynamics of ziprasidone in children and adolescents: impact on dopamine transmission.Journal of the American Academy of Child and Adolescent Psychiatry, , 42 (8 ) ,902-7 More Information
de Wildt, S N; de Hoog, M; Vinks, A A; van der Giesen, E; van den Anker, J N (2003. ) Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients.Critical care medicine, , 31 (7 ) ,1952-8 More Information
Le Brun, P P H; de Boer, A H; Mannes, G P M; de Fraîture, D M I; Brimicombe, R W; Touw, D J; Vinks, A A; Frijlink, H W; Heijerman, H G M (2002. ) Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2. Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , 54 (1 ) ,25-32 More Information
de Hoog, Matthijs; Schoemaker, Rik C; van den Anker, John N; Vinks, Alexander A (2002. ) NONMEM and NPEM2 population modeling: a comparison using tobramycin data in neonates.Therapeutic drug monitoring, , 24 (3 ) ,359-65 More Information
Ververs, T F; van Dijk, A; Vinks, S A; Blankestijn, P J; Savelkoul, J F; Meulenbelt, J; Boereboom, F T (2000. ) Pharmacokinetics and dosing regimen of meropenem in critically ill patients receiving continuous venovenous hemofiltration.Critical care medicine, , 28 (10 ) ,3412-6 More Information
Le Brun, P P; de Graaf, A I; Vinks, A A (2000. ) High-performance liquid chromatographic method for the determination of colistin in serum.Therapeutic drug monitoring, , 22 (5 ) ,589-93 More Information
Mouton, J W; Touzw, D J; Horrevorts, A M; Vinks, A A (2000. ) Comparative pharmacokinetics of the carbapenems: clinical implications.Clinical pharmacokinetics, , 39 (3 ) ,185-201 More Information
Natsch, S; Vinks, M H; Voogt, A K; Mees, E B; Meyboom, R H (2000. ) Anaphylactic reactions to proton-pump inhibitors.The Annals of pharmacotherapy, , 34 (4 ) ,474-6 More Information
Beringer, P M; Vinks, A A; Jelliffe, R W; Shapiro, B J (2000. ) Pharmacokinetics of tobramycin in adults with cystic fibrosis: implications for once-daily administration.Antimicrobial agents and chemotherapy, , 44 (4 ) ,809-13 More Information
Le Brun, P P; Vinks, A A; Touw, D J; Hekelaar, N; Mannes, G P; Brimicombe, R W; Frijlink, E H; Heijerman, H G (1999. ) Can tobramycin inhalation be improved with a jet nebulizer?.Therapeutic drug monitoring, , 21 (6 ) ,618-24 More Information
Morris, R G; Sallustio, B C; Vinks, A A; LeGatt, D F; Verjee, Z H; El Desoky, E (1999. ) Some international approaches to aminoglycoside monitoring in the extended dosing interval era.Therapeutic drug monitoring, , 21 (4 ) ,379-88 More Information
van Lent-Evers, N A; Mathôt, R A; Geus, W P; van Hout, B A; Vinks, A A (1999. ) Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis.Therapeutic drug monitoring, , 21 (1 ) ,63-73 More Information
Touw, D J; Vinks, A A; Mouton, J W; Horrevorts, A M (1998. ) Pharmacokinetic optimisation of antibacterial treatment in patients with cystic fibrosis. Current practice and suggestions for future directions.Clinical pharmacokinetics, , 35 (6 ) ,437-59 More Information
Visser, L; Stricker, B; Hoogendoorn, M; Vinks, A (1998. ) Do not give paraffin to packers.Lancet (London, England), , 352 (9137 ) ,1352 More Information
Beringer, P M; Vinks, A A; Jelliffe, R W (1998. ) Pharmacokinetics of once-daily amikacin dosing in patients with cystic fibrosis.The Journal of antimicrobial chemotherapy, , 41 (1 ) ,142-4 More Information
Meyboom, R H; van Puijenbroek, E P; Vinks, M H; Lastdrager, C J (1997. ) Disturbance of withdrawal bleeding during concomitant use of itraconazole and oral contraceptives. The New Zealand medical journal, , 110 (1049 ) ,300
Vinks, A A; Brimicombe, R W; Heijerman, H G; Bakker, W (1997. ) Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics.The Journal of antimicrobial chemotherapy, , 40 (1 ) ,125-33 More Information
Touw, D J; Vinks, A A; Neef, C (1997. ) Pharmacokinetic modelling of intravenous tobramycin in adolescent and adult patients with cystic fibrosis using the nonparametric expectation maximization (NPEM) algorithm.Pharmacy world & science : PWS, , 19 (3 ) ,142-51 More Information
Mouton, J W; Vinks, A A; Punt, N C (1997. ) Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion.Antimicrobial agents and chemotherapy, , 41 (4 ) ,733-8 More Information
Town, D J; Vinks, A A; Jacobs, F; Heijerman, H G; Bakker, W (1996. ) Creatinine clearance as predictor of tobramycin elimination in adult patients with cystic fibrosis.Therapeutic drug monitoring, , 18 (5 ) ,562-9 More Information
Mouton, J W; Vinks, A A (1996. ) Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations.The Journal of antimicrobial chemotherapy, , 38 (1 ) ,5-15 More Information
Vinks, A A; Mouton, J W; Touw, D J; Heijerman, H G; Danhof, M; Bakker, W (1996. ) Population pharmacokinetics of ceftazidime in cystic fibrosis patients analyzed by using a nonparametric algorithm and optimal sampling strategy.Antimicrobial agents and chemotherapy, , 40 (5 ) ,1091-7 More Information
Vinks, A A; Touw, D J; van Rossen, R C; Heijerman, H G; Bakker, W (1996. ) Stability of aztreonam in a portable pump reservoir used for home intravenous antibiotic treatment (HIVAT).Pharmacy world & science : PWS, , 18 (2 ) ,74-7 More Information
Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W (1996. ) Prospective evaluation of a dose prediction algorithm for intravenous tobramycin in adolescent and adult patients with cystic fibrosis.Therapeutic drug monitoring, , 18 (2 ) ,118-23 More Information
Vinks, A A; Touw, D J; Heijerman, H G; Danhof, M; de Leede, G P; Bakker, W (1994. ) Pharmacokinetics of ceftazidime in adult cystic fibrosis patients during continuous infusion and ambulatory treatment at home.Therapeutic drug monitoring, , 16 (4 ) ,341-8 More Information
Touw, D J; Vinks, A A; Heijerman, H G; Hermans, J; Bakker, W (1994. ) Suggestions for the optimization of the initial tobramycin dose in adolescent and adult patients with cystic fibrosis.Therapeutic drug monitoring, , 16 (2 ) ,125-31 More Information
Bakker, W; Vinks, A A; Mouton, J W; de Jonge, P; Verzijl, J G; Heijerman, H G (1993. ) [Continuous intravenous home treatment of airway infections using ceftazidime administration via portable pump in patients with cystic fibrosis; a multicenter study]. Nederlands tijdschrift voor geneeskunde, , 137 (48 ) ,2486-91
Mouton, J W; Vinks, A A (1993. ) [Antimicrobial treatment using beta-lactam antibiotics: continuous infusion appears to be sensible]. Nederlands tijdschrift voor geneeskunde, , 137 (48 ) ,2476-80
Geus, W P; Vinks, A A; Smith, S J; Westra, P; Lamers, C B (1993. ) Comparison of two intravenous ranitidine regimens in a homogeneous population of intensive care unit patients.Alimentary pharmacology & therapeutics, , 7 (4 ) ,451-7 More Information
Vinks, S A; Heijerman, H G; de Jonge, P; Bakker, W (1993. ) Photosensitivity due to ambulatory intravenous ceftazidime in cystic fibrosis patient.Lancet (London, England), , 341 (8854 ) ,1221-2 More Information
Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W (1993. ) Validation of tobramycin monitoring in adolescent and adult patients with cystic fibrosis.Therapeutic drug monitoring, , 15 (1 ) ,52-9 More Information
Melissant, C F; Vinks, A A; Sleeboom, H P (1992. ) [Coma due to an overdose of valnoctamide]. Nederlands tijdschrift voor geneeskunde, , 136 (16 ) ,793-4
Geus, W P; Vinks, A A; Lamers, C B (1992. ) Pharmacokinetics of ranitidine in a homogeneous population of intensive care unit patients during intermittent and continuous administration.Scandinavian journal of gastroenterology. Supplement, , 194 ,55-8 More Information
Hoogslag, P A; van Dijk, B; Vinks, A A (1989. ) [Respiratory depression following controlled-release morphine sulfate tablets]. Nederlands tijdschrift voor geneeskunde, , 133 (10 ) ,516-7
Keukens, F; van Voorst Vader, P C; Panders, A K; Vinks, S; Oosterhuis, J W; Kleijer, W J (1989. ) Xeroderma pigmentosum: squamous cell carcinoma of the tongue. Acta dermato-venereologica, , 69 (6 ) ,530-1
Inaba, T; Vinks, A; Otton, S V (1986. ) A simple borohydride/GC method for measuring sparteine metabolites in man.British journal of clinical pharmacology, , 21 (5 ) ,473-80 More Information
Van der Graaff, M; Vermeulen, N P; Vinks, M H; Breimer, D D (1986. ) Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat.European journal of drug metabolism and pharmacokinetics, , 11 (2 ) ,107-11 More Information
Slee, G L; Vinks, J A (1983. ) [Ileus following the use of loperamide (Imodium)]. Nederlands tijdschrift voor geneeskunde, , 127 (40 ) ,1821-2
Inaba, T; Vinks, A; Otton, S V; Kalow, W (1983. ) Comparative pharmacogenetics of sparteine and debrisoquine.Clinical pharmacology and therapeutics, , 33 (3 ) ,394-9 More Information
Vinks, A; Inaba, T; Otton, S V; Kalow, W (1982. ) Sparteine metabolism in Canadian Caucasians.Clinical pharmacology and therapeutics, , 31 (1 ) ,23-9 More Information
McIntire, Carter; Luna Torres, Julie; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Tang Girdwood, Sonya (2023. ) Piperacillin Pharmacokinetics and Pharmacodynamics in Paediatric Patients Who Received High Frequency Intra-Operative Piperacillin/Tazobactam Dosing.International journal of antimicrobial agents, , 63 (3 ) ,107079 More Information
Taylor, Zachary L; Poweleit, Ethan A; Paice, Kelli; Somers, Katherine M; Pavia, Kathryn; Vinks, Alexander A; Punt, Nieko; Mizuno, Tomoyuki; Girdwood, Sonya Tang (2023. ) Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing.CPT: pharmacometrics & systems pharmacology, , 12 (12 ) ,1827-1845 More Information
Cervantes, Francisco C; Mizuno, Tomoyuki; Dong, Min; Tang, Peter; Arbough, Trent; Vinks, Alexander A; Kaplan, Jennifer M; Tang Girdwood, Sonya C (2023. ) Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy.Therapeutic drug monitoring, , 45 (6 ) ,832-836 More Information
Power-Hays, Alexandra; Dong, Min; Punt, Nieko; Mizuno, Tomoyuki; Smart, Luke R; Vinks, Alexander A; Ware, Russell E (2023. ) Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia.Clinical pharmacology and therapeutics, , More Information
Pavia, Kathryn; Hambrick, H Rhodes; Paice, Kelli; Tang, Peter; Punt, Nieko; Kaplan, Jennifer; Goldstein, Stuart L; Vinks, Alexander A; Mizuno, Tomoyuki; Tang Girdwood, Sonya (2023. ) Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy.The Journal of antimicrobial chemotherapy, , 78 (9 ) ,2140-2147 More Information
Choi, Yewon; Vinks, Alexander A; van der Graaf, Piet H (2023. ) Novel Therapeutic Modalities: The Future is Now.Clinical pharmacology and therapeutics, , 114 (3 ) ,493-496 More Information
Jodele, Sonata; Mizuno, Kana; Sabulski, Anthony; Vinks, Alexander A (2023. ) Adopting Model-Informed Precision-Dosing for Eculizumab in Transplant Associated-Thrombotic Microangiopathy to Gene Therapies.Clinical pharmacology and therapeutics, , 114 (3 ) ,511-514 More Information
Mizuno, Kana; Capparelli, Edmund V; Fukuda, Tsuyoshi; Dong, Min; Adamson, Peter C; Blumer, Jeffery L; Cnaan, Avital; Clark, Peggy O; Reed, Michael D; Shinnar, Shlomo; Vinks, Alexander A; Glauser, Tracy A (2023. ) Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy.Clinical pharmacology and therapeutics, , 114 (2 ) ,459-469 More Information
Smart, Luke R; Charles, Mwesige; McElhinney, Kathryn E; Dong, Min; Power-Hays, Alexandra; Howard, Thad; Vinks, Alexander A; Ambrose, Emmanuela E; Ware, Russell E (2023. ) Hydroxyurea pharmacokinetics and precision dosing in low-resource settings.Frontiers in molecular biosciences, , 10 ,1130206 More Information
Dong, Min; Ware, Russell E; Dallmann, André; Vinks, Alexander A (2023. ) Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps.Pharmacotherapy, , 43 (5 ) ,419-429 More Information