Alexander Vinks

Alexander Vinks

Professor-Affiliate

Childrens Hospital Bldg R

2529

COM Pediatrics Clinical Pharmacology - 0054

Professional Summary

Dr. Vinks' current research interests include pharmacokinetic-pharmacodynamic (PK-PD) modeling and the application of population and simulation methods in TDM and clinical trial design. He has authored over 50 publications in the area of TDM, pharmacokinetics and clinical pharmacology.

Publications

Peer Reviewed Publications

Fukuda, Tsuyoshi; Goebel, Jens; Cox, Shareen; Maseck, Denise; Zhang, Kejian; Sherbotie, Joseph R; Ellis, Eileen N; James, Laura P; Ward, Robert M; Vinks, Alexander A (2012. ) UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients.Therapeutic drug monitoring, , 34 (6 ) ,671-679 More Information

Wiles, Jason R; Vinks, Alexander A; Akinbi, Henry (2012. ) Federal Legislation and the Advancement of Neonatal Drug Studies.The Journal of pediatrics, , More Information

Ngamprasertwong, Pornswan; Vinks, Alexander A; Boat, Anne (2012. ) Update in Fetal Anesthesia for the Ex Utero Intrapartum Treatment (EXIT) Procedure.International anesthesiology clinics, , 50 (4 ) ,26-40 More Information

Sherwin, Catherine M T; Saldaña, Shannon N; Bies, Robert R; Aman, Michael G; Vinks, Alexander A (2012. ) Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents.Therapeutic drug monitoring, , 34 (5 ) ,535-44 More Information

Sadhasivam, Senthilkumar; Krekels, Elke H J; Chidambaran, Vidya; Esslinger, Hope R; Ngamprasertwong, Pornswan; Zhang, Kejian; Fukuda, Tsuyoshi; Vinks, Alexander A Morphine clearance in children: does race or genetics matter?.Journal of opioid management, , 8 (4 ) ,217-26 More Information

Sherwin, Catherine M T; Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Brunner, Hermine I; Vinks, Alexander A (2012. ) Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus.British journal of clinical pharmacology, , 73 (5 ) ,727-40 More Information

Chidambaran, Vidya; Ngamprasertwong, Pornswan; Vinks, Alexander A; Sadhasivam, Senthilkumar (2012. ) Pharmacogenetics and anesthetic drugs. Current clinical pharmacology, , 7 (2 ) ,78-101

Hooper, David K; Fukuda, Tsuyoshi; Gardiner, Rhonda; Logan, Barbara; Roy-Chaudhury, Ashwini; Kirby, Cassie L; Vinks, Alexander A; Goebel, Jens (2012. ) Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation.Transplantation, , 93 (8 ) ,806-12 More Information

Saldaña, Shannon N; Hooper, David K; Froehlich, Tanya E; Campbell, Kathleen M; Prows, Cynthia A; Sadhasivam, Senthilkumar; Nick, Todd G; Seid, Michael; Vinks, Alexander A; Glauser, Tracy A (2011. ) Characteristics of successful recruitment in prospective pediatric pharmacogenetic studies.Clinical therapeutics, , 33 (12 ) ,2072-81 More Information

Sagcal-Gironella, Anna Carmela P; Sherwin, Catherine M T; Tirona, Rommel G; Rieder, Michael J; Brunner, Hermine I; Vinks, Alexander A (2011. ) Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study.Clinical therapeutics, , 33 (10 ) ,1524-36 More Information

Fukuda, Tsuyoshi; Brunner, Hermine I; Sagcal-Gironella, Anna Carmela P; Vinks, Alexander A (2011. ) Nonsteroidal anti-inflammatory drugs may reduce enterohepatic recirculation of mycophenolic acid in patients with childhood-onset systemic lupus erythematosus.Therapeutic drug monitoring, , 33 (5 ) ,658-62 More Information

Sherwin, Catherine M T; Ding, Lili; Kaplan, Jennifer; Spigarelli, Michael G; Vinks, Alexander A (2011. ) Optimal study design for pioglitazone in septic pediatric patients.Journal of pharmacokinetics and pharmacodynamics, , 38 (4 ) ,433-47 More Information

Merhar, Stephanie L; Schibler, Kurt R; Sherwin, Catherine M; Meinzen-Derr, Jareen; Shi, Jing; Balmakund, Tonya; Vinks, Alexander A (2011. ) Pharmacokinetics of levetiracetam in neonates with seizures.The Journal of pediatrics, , 159 (1 ) ,152-154.e3 More Information

Fukuda, Tsuyoshi; Goebel, Jens; Thøgersen, Håvard; Maseck, Denise; Cox, Shareen; Logan, Barbara; Sherbotie, Joseph; Seikaly, Mouin; Vinks, Alexander A (2011. ) Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients.Journal of clinical pharmacology, , 51 (3 ) ,309-20 More Information

Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Wiers, Kristina; Cox, Shareen; Nelson, Shannen; Dina, Blair; Sherwin, Catherine M T; Klein-Gitelman, Marisa S; Vinks, Alexander A; Brunner, Hermine I (2011. ) Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus.Seminars in arthritis and rheumatism, , 40 (4 ) ,307-13 More Information

Sherwin, Catherine M T; Fukuda, Tsuyoshi; Brunner, Hermine I; Goebel, Jens; Vinks, Alexander A (2011. ) The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease.Clinical pharmacokinetics, , 50 (1 ) ,1-24 More Information

Mehta, Parinda A; Vinks, Alexander A; Filipovich, Alexandra; Bleesing, Jack; Jodele, Sonata; Jordan, Michael B; Marsh, Rebecca; Tarin, Richard; Edwards, Stephanie; Fearing, Deborah; Lawrence, Julia; Davies, Stella M (2010. ) Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 16 (10 ) ,1458-62 More Information

Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Capparelli, Edmund V; Adamson, Peter C (2010. ) Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.The New England journal of medicine, , 362 (9 ) ,790-9 More Information

Vargus-Adams, Jilda N; McMahon, Mary A; Michaud, Linda J; Bean, Judy; Vinks, Alexander A (2010. ) Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique.PM & R : the journal of injury, function, and rehabilitation, , 2 (1 ) ,37-42 More Information

Prows, Cynthia A; Nick, Todd G; Saldaña, Shannon N; Pathak, Sanjeev; Liu, Chunyan; Zhang, Kejian; Daniels, Zachary S; Vinks, Alexander A; Glauser, Tracy A (2009. ) Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients.Journal of child and adolescent psychopharmacology, , 19 (4 ) ,385-94 More Information

Pestian, John; Spencer, Malik; Matykiewicz, Pawel; Zhang, Kejian; Vinks, Alexander A; Glauser, Tracy (2009. ) Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomedical informatics insights, , 2 ,19-29

Prausa, S E; Fukuda, T; Maseck, D; Curtsinger, K L; Liu, C; Zhang, K; Nick, T G; Sherbotie, J R; Ellis, E N; Goebel, J; Vinks, A A (2009. ) UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.Clinical pharmacology and therapeutics, , 85 (5 ) ,495-500 More Information

Rogers, Christin C; Alloway, Rita R; Alexander, J Wesley; Cardi, Michael; Trofe, Jennifer; Vinks, Alexander A Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study.Clinical transplantation, , 22 (3 ) ,281-91 More Information

Vinks, Alexander A; van Rossem, Ronald N; Mathôt, Ron A A; Heijerman, Harry G M; Mouton, Johan W (2007. ) Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation.Antimicrobial agents and chemotherapy, , 51 (9 ) ,3049-55 More Information

Cabovska, B; Cox, S L; Vinks, A A (2007. ) Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , 852 (1-2 ) ,497-504 More Information

Jiang, Zhengwen; Dragin, Nadine; Jorge-Nebert, Lucia F; Martin, Martha V; Guengerich, F Peter; Aklillu, Eleni; Ingelman-Sundberg, Magnus; Hammons, George J; Lyn-Cook, Beverly D; Kadlubar, Fred F; Saldana, Shannon N; Sorter, Michael; Vinks, Alexander A; Nassr, Nassr; von Richter, Oliver; Jin, Li; Nebert, Daniel W (2006. ) Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.Pharmacogenetics and genomics, , 16 (5 ) ,359-67 More Information

Mehta, Parinda; Vinks, Alexander; Filipovich, Alexandra; Vaughn, Gretchen; Fearing, Deborah; Sper, Christine; Davies, Stella (2006. ) High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 12 (2 ) ,235-40 More Information

Williams, Michael T; Brown, Carrie A; Skelton, Matthew R; Vinks, Alexander A; Vorhees, Charles V Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats.Neurotoxicology and teratology, , 26 (6 ) ,849-56 More Information

Vinks, Alexander A; Den Hollander, Jan G; Overbeek, Shelley E; Jelliffe, Roger W; Mouton, Johan W (2003. ) Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis. Antimicrobial agents and chemotherapy, , 47 (2 ) ,541-7

Vinks, Alexander A (2002. ) The application of population pharmacokinetic modeling to individualized antibiotic therapy. International journal of antimicrobial agents, , 19 (4 ) ,313-22