Lisa Privette Vinnedge

PhD: University of Michigan Ann Arbor, MI, 2008 (Human Genetics)

MS: University of Michigan Ann Arbor, MI, 2004 (Human Genetics)

BS: Miami University Oxford, OH, 2002 (Microbiology and Classical Humanities)

Postdoctoral Fellow: Cincinnati Children's Hospital Medical Center Cincinnati, OH, 2012 (Oncology)

My long-standing research interest is to elucidate the molecular genetic mechanisms that regulate mammary gland development and breast pathology, such as breast cancer. My lab uses a combination of mouse and human models, including 2D and 3D cell culture models, patient tissues, xenograft tumors, and genetically engineered mouse models. Using these tools, my research career has focused on identifying and characterizing novel tumor suppressors and oncogenes that regulate genome stability, DNA damage responses, and/or chromatin remodeling. 

My lab also has long-standing collaborations that broadly fall into two categories: (1) drug discovery projects, wherein my lab performs pre-clinical efficacy trials for new cancer therapeutics and (2) impaired memory and cognition as they pertain to genetic risks or side effects from chemotherapy, with a particular focus on sex differences.

My second professional interest is in mentoring and professional development of trainees. To this end, I hold leadership roles in programs that support research experiences for undergraduates and professional development of postdoctoral fellows. 

2009 -2014 Adjunct Instructor, Departments of Biology and Microbiology, Miami University, Regional campuses

2014 - Director, Office of Postdoctoral Affairs, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Peer Reviewed Publications

Wilcher, Katherine E; Page, Evan R H; Privette Vinnedge, Lisa M (2023. ) The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia.Experimental hematology, , 123 ,18-27 More Information

Singh, Navneet; Romick-Rosendale, Lindsey; Watanabe-Chailland, Miki; Privette Vinnedge, Lisa M; Komurov, Kakajan (2022. ) Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers.PloS one, , 17 (12 ) ,e0256788 More Information

Greene, Allie N; Solomon, Matia B; Privette Vinnedge, Lisa M (2022. ) Novel molecular mechanisms in Alzheimer's disease: The potential role of DEK in disease pathogenesis.Frontiers in aging neuroscience, , 14 ,1018180 More Information

Greene, Allie N; Nguyen, Elizabeth T; Paranjpe, Aditi; Lane, Adam; Privette Vinnedge, Lisa M; Solomon, Matia B (2022. ) In silico gene expression and pathway analysis of DEK in the human brain across the lifespan.The European journal of neuroscience, , 56 (6 ) ,4720-4743 More Information

Muhammad, B; Parks, L G; Komurov, K; Privette Vinnedge, L M (2022. ) Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability.Translational oncology, , 16 ,101323 More Information

Greene, Allie N; Parks, Lois G; Solomon, Matia B; Privette Vinnedge, Lisa M (2020. ) Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells.Frontiers in molecular neuroscience, , 13 ,594319 More Information

Wen, Yu; Xu, He N; Privette Vinnedge, Lisa; Feng, Min; Li, Lin Z (2019. ) Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells.Molecular imaging and biology, , 21 (3 ) ,410-416 More Information

O'Donovan, Sinead M; Franco-Villanueva, Ana; Ghisays, Valentina; Caldwell, Jody L; Haroutunian, Vahraim; Privette Vinnedge, Lisa M; McCullumsmith, Robert E; Solomon, Matia B (2018. ) Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia.Schizophrenia research, , 202 ,188-194 More Information

Modur, Vishnu; Singh, Navneet; Mohanty, Vakul; Chung, Eunah; Muhammad, Belal; Choi, Kwangmin; Chen, Xiaoting; Chetal, Kashish; Ratner, Nancy; Salomonis, Nathan; Weirauch, Matthew T; Waltz, Susan; Huang, Gang; Privette-Vinnedge, Lisa; Park, Joo-Seop; Janssen, Edith M; Komurov, Kakajan (2018. ) Defective transcription elongation in a subset of cancers confers immunotherapy resistance.Nature communications, , 9 (1 ) ,4410 More Information

Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M (2018. ) Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.Experimental hematology, , 59 ,40-50.e3 More Information

Ghisays, Valentina; Nguyen, Elizabeth T; Streicher, Joshua; Pease, Nicholas A; Fitzgerald, Maureen; Estrada, Christina M; Franco-Villanueva, Ana; Privette Vinnedge, Lisa; Solomon, Matia B (2018. ) Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice.Neuroscience, , 371 ,254-267 More Information

Wise-Draper, Trisha; Sendilnathan, Arun; Palackdharry, Sarah; Pease, Nicholas; Qualtieri, Julianne; Butler, Randall; Sadraei, Nooshin Hashemi; Morris, John C; Patil, Yash; Wilson, Keith; Mark, Jonathan; Casper, Keith; Takiar, Vinita; Lane, Adam; Privette Vinnedge, Lisa (2018. ) Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case-Control Study of Patients with Head and Neck Squamous Cell Carcinoma.Translational oncology, , 11 (1 ) ,168-174 More Information

Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I (2016. ) Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Clinical cancer research : an official journal of the American Association for Cancer Research, , 22 (8 ) ,2062-73 More Information

Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I (2015. ) The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.Oncogene, , 34 (18 ) ,2325-36 More Information

Pease, Nicholas A; Wise-Draper, Trisha; Privette Vinnedge, Lisa (2015. ) Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer.Journal of oncology, , 2015 ,106517 More Information

Privette Vinnedge, Lisa M; Kappes, Ferdinand; Nassar, Nicolas; Wells, Susanne I (2013. ) Stacking the DEK: from chromatin topology to cancer stem cells.Cell cycle (Georgetown, Tex.), , 12 (1 ) ,51-66 More Information

Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.PloS one, , 7 (10 ) ,e46985 More Information

Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I (2011. ) The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.Oncogene, , 30 (24 ) ,2741-52 More Information

Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N (2022. ) Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.Leukemia, , 36 (3 ) ,637-647 More Information

Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette (2020. ) DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages.Cancers, , 12 (7 ) , More Information

Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N (2020. ) IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.PloS one, , 15 (3 ) ,e0229801 More Information

Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I (2017. ) DEK is required for homologous recombination repair of DNA breaks.Scientific reports, , 7 ,44662 More Information

Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N (2022. ) Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.Leukemia, , 36 (3 ) ,637-647 More Information

Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette (2020. ) DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages.Cancers, , 12 (7 ) , More Information

Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N (2020. ) IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.PloS one, , 15 (3 ) ,e0229801 More Information

Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I (2017. ) DEK is required for homologous recombination repair of DNA breaks.Scientific reports, , 7 ,44662 More Information

Gonzalez, Maria E; Makarova, Olga; Peterson, Esther A; Privette, Lisa M; Petty, Elizabeth M (2009. ) Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells.Cellular signalling, , 21 (4 ) ,477-87 More Information

Privette, Lisa M; Petty, Elizabeth M (2008. ) CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis.Translational oncology, , 1 (2 ) ,57-64 More Information

Privette, Lisa M; Weier, Jingly Fung; Nguyen, Ha Nam; Yu, Xiaochun; Petty, Elizabeth M (2008. ) Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint.Neoplasia (New York, N.Y.), , 10 (7 ) ,643-52 More Information

Gonzalez, Maria E; Peterson, Esther A; Privette, Lisa M; Loffreda-Wren, Janice L; Kalikin, Linda M; Petty, Elizabeth M (2007. ) High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes.Cancer research, , 67 (18 ) ,8554-64 More Information

Privette, Lisa M; González, Maria E; Ding, Lei; Kleer, Celina G; Petty, Elizabeth M (2007. ) Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression.Cancer research, , 67 (13 ) ,6064-74 More Information

Research - Building T, Room T7.486
3333 Burnet Avenue
Cincinnati  Ohio, 45229
lisa.privette@cchmc.org