Susan E. Waltz , PhD

The Waltz laboratory is interested in the molecular mechanisms by which cell-surface receptor tyrosine kinases and growth factors control human disease processes, with a special emphasis on mechanisms regulating cancer growth and metastasis, and inflammation. The Waltz group has made several seminal discoveries related to the Ron receptor tyrosine kinase in both breast and prostate cancers. In particular, the laboratory has shown that Ron overexpression specific to the breast epithelium is sufficient to induce aggressive breast cancers that are highly metastatic. In addition, the Waltz group has found that Ron is an important contributing factor controlling the growth of prostate cancers through the regulation of tumor angiogenesis (blood vessel formation). The immediate goals for these projects are to understand the physiological signaling pathways that control the aggressive tumor phenotype downstream of Ron signaling. Future studies will involve the utilization of in vivo gene-targeted murine models to study disease progression as well as the isolation and analysis of primary epithelial and stromal cells from the breast and prostate environments. In addition, the laboratory plans to use orthotopic transplantation of gene-modified cell lines into syngeneic models to explore these signaling pathways in detail.

With respect to control of cellular inflammation, the Waltz laboratory has also shown that Ron is expressed on select macrophage populations, and that signaling through this receptor negatively regulates the balance of cytokine and chemokine production during acute tissue injury in vivo. This critical balance of immune mediators is essential to control the body's response to injury, wounding, and infection. To analyze the mechanisms responsible for the Ron-dependent regulation of cytokine/chemokine production, the laboratory utilizes co-culture systems composed of primary tissue macrophages and epithelial cells from select gene knockout animals to dissect the role of macrophages in tissue injury. The overall goal of the Waltz laboratory is to examine the Ron signaling pathway as a novel therapeutic target in the regulation of a variety of human diseases.

Doctoral Degree: Boonshoft School of Medicine, Wright State University 1994 (Biochemistry and Molecular Biology )

Bachelor's Degree: Youngstown State University 1989 (Biology/Chemistry)

Postdoctoral Fellowship: Cincinnati Children's Hospital Research Foundation Cincinnati, OH, 1997 (Growth factors and receptor tyrosine kinases in human disease )

Receptor Tyrosine Kinase Signaling
Tumor Microenvironment
Breast and Prostate Cancer
Stem Cell Biology
Macrophages and Tumorigenesis
Mechanisms of Therapeutic Resistance

1997 -2003 Assistant Professor, Department of Pediatrics Division of Developmental Biology , Cincinnati Children's Hospital Research Foundation, 3333 Burnet Ave., Cincinnati, Ohio 45229-3039

2003 -2008 Associate Professor, Department of Surgery , University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0558

2005 -2008 Director, Oncology Research Program, Department of Surgery , University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0558

2007 -2009 Interim Scientific Director, University of Cincinnati Barrett Cancer Center/Joint Cancer Center Program, University of Cincinnati, Cincinnati, OH

2003 -To Present Faculty Mentor, Graduate Programs in Cancer and Cell Biology, Molecular and Developmental Biology, Systems Biology and the Physician Scientist Training Programs., University of Cincinnati, Cincinnati, OH

2008 -2012 Director, Graduate Program in Cancer and Cell Biology,

2008 -To Present Professor , Department of Cancer Biology, University of Cincinnati, Cincinnati, OH

01-01-2018 -To Present Director, Graduate Program in Cancer and Cell Biology, University of Cincinnati College of Medicine,

Grant: #NCI R01CA239697 Investigators:Waltz, Susan 04-01-2020 -03-31-2025 National Institutes of Health Defining genetic and metabolic requirements of aggressive breast cancer Role:PI $506,269.00 Active Level:Federal

Grant: #F31CA228425 Investigators:Sullivan, Camille; Waltz, Susan 03-17-2019 -03-16-2020 National Cancer Institute Macrophage Ron signaling regulates the antitumor immune response in prostate cancer Role:Collaborator $41,545.00 Awarded Level:Federal

Grant: #R15CA224104 Investigators:Baccei, Mark; Shaughnessy, Elizabeth; Waltz, Susan; Weber, Georg; Ying, Jun 09-15-2018 -08-31-2021 National Cancer Institute Metabolic Mechanisms in Cancer Progression Role:Collaborator $479,534.00 Active Level:Federal

Grant: #T32CA117846 Investigators:Price, Carolyn; Waltz, Susan 09-01-2018 -08-31-2023 National Cancer Institute Pathways to Cancer Therapeutics Role:PI $459,588.00 Active Level:Federal

Grant: #F31 HL137310 Investigators:Niederkorn, Madeline; Waltz, Susan 07-01-2018 -06-30-2021 National Heart, Lung and Blood Institute The TIFAB-USP15 Complex in the Pathogenesis of MDS and AML Role:PI $32,384.00 Awarded Level:Federal

Grant: #VA Billing Agreement Brown Investigators:Brown, Nicholas; Waltz, Susan 07-01-2018 -06-30-2019 Department of Veterans Affairs VA Contract - Nick Brown Role:Collaborator $31,030.00 Active Level:Federal

Grant: #VA Billing Agreement Ruiz-Torres sub VA Merit 7T01BX000803-07 Investigators:Ruiz-Torres, Sasha; Waltz, Susan 07-01-2018 -06-30-2019 Department of Veterans Affairs VA Contract - Sasha Ruiz-Torres Role:Collaborator $31,030.00 Active Level:Federal

Grant: #139984 / F30 HL137239 Investigators:Maliken, Bryan; Waltz, Susan 09-30-2017 -09-29-2021 National Heart, Lung and Blood Institute Cardiovascular Impact of Gata4 Loss in the c-Kit Lineage Role:Collaborator $44,844.00 Active Level:Federal

Grant: #F31CA200390 Investigators:Waltz, Susan E 07-01-2016 -06-30-2018 NIH THE RON RECEPTOR IN CASTRATION RESISTANT PROSTATE CANCER Role:Mentor Active Type:Grant

Grant: #ES023942 Investigators:Susan E Waltz 02-01-2015 -01-31-2019 NIH EARLY EXPOSURE TO PHTHALATE & OBESITY: THE ROLE OF PCNA TYROSINE PHOSPHORYLATION Role:PI $150,000 Active Type:Grant Level:National

Grant: #RON Inhibitior Investigators:Waltz, Susan 08-01-2014 -12-31-2014 Lead Discovery Center GmbH Use of novel Ron inhibitors to target cancer growth in vivo Role:PI $42,875.00 Completed

Grant: #VA IPA - Nashu Investigators:Waltz, Susan 02-01-2013 -12-31-2014 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Madison Nashu Role:PI $88,190.00 Completed Type:Grant Level:National

Grant: #F31CA165767 Investigators:Paluch, Andrew; Waltz, Susan 09-30-2012 -09-29-2017 National Cancer Institute Lineage-Specific Roles for the Ron-Receptor in Prostate Cancer Role:Collaborator $69,050.00 Completed Type:Fellowship Level:National

Grant: #T32CA117846 Investigators:Waltz, Susan 09-14-2012 -08-31-2018 National Cancer Institute Training Program in Cancer Therapeutics Role:M-PI $742,942.00 Active Type:Grant Level:National

Grant: #W81XWH-12-1-0195 Investigators:Waltz, Susan 09-01-2012 -08-31-2016 Department of the Army Medical Research Acquisition Activity Targeting the Ron-DEK Signaling Axis in Breast Cancer Role:PI $392,500.00 Completed Type:Grant Level:National

Grant: #12POST12040055 Investigators:Kulkarni, Rishikesh; Waltz, Susan 07-01-2012 -06-30-2014 American Heart Association Ron receptor signaling regulates innate immune responses in alvelolar macrophages Role:Mentor 93,000 Active Type:Fellowship Level:Regional

Grant: #PO# 10320965 / R01 CA155620-01A1 Investigators:Waltz, Susan 09-22-2011 -07-31-2016 National Cancer Institute RON Receptor in Pancreatic Cancer Biology and Treatment Role:PI $70,646.43 Active Level:Federal

Grant: #SRS 7696 Investigators:Kulkarni, Rishikesh; Waltz, Susan 08-01-2011 -09-30-2011 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Rishikesh Kulkarni Role:PI $7,280.00 Completed Type:Grant Level:National

Grant: #R21 DK091917 Investigators:Kleene, Nancy; Kleene, Steven; Soleimani, Manoocher; Waltz, Susan 07-26-2011 -04-30-2014 National Inst of Diabetes and Digestive and Kidney Disease Chemosensory Transduction in a Primary Cilium Role:Collaborator $431,750.00 Active Level:Federal

Grant: #W81XWH-11-1-0377 Investigators:Gurusamy, Devikala; Waltz, Susan 05-01-2011 -04-30-2014 Department of the Army Role of Ron Receptor Tyrosine Kinase in Promoting Prostate Tumor Growth in Vivo Role:Collaborator $99,900.00 Active Type:Fellowship Level:National

Grant: #W81XWH-11-1-0323 Investigators:Ho, Shuk Mei; Isaac, Jared; Waltz, Susan 04-01-2011 -07-20-2012 Department of the Army Medical Research Acquisition Activity Investigation of S-Nitrosylation of Integrin Alpha 6 in Prostate Cancer Metastasis Role:Collaborator $38,979.81 Completed Type:Fellowship Level:National

Grant: #SRS 007254 Investigators:Gray, Jerilyn; Waltz, Susan 01-01-2011 -12-31-2012 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Jerilyn Gray Role:PI $100,848.00 Completed Type:Grant Level:National

Grant: #SRS 007255 Investigators:Stuart, William Douglas; Waltz, Susan 01-01-2011 -12-31-2013 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for William Stuart Role:PI $212,964.00 Active Level:Federal

Grant: #I01BX000803 Investigators:Waltz, Susan E 10-01-2010 -03-31-2020 VETERANS AFFAIRS RON RECEPTOR TYROSINE KINASE SIGNALING IN BREAST CANCER Role:PI Active Type:Grant

Grant: #KG090377 Investigators:Waltz, Susan; Zinser, Glendon Michael 10-28-2009 -10-27-2014 Susan G. Komen Breast Cancer Foundation Breast Adipose Bioactivates Vitamin D and Contributes to Cancer Prevention Role:PI $381,250.00 Active Type:Grant Level:National

Grant: #W81XWH-09-1-0673 Investigators:Drew, Angela; Husseinzadeh, Nader; Waltz, Susan 09-15-2009 -01-14-2013 Department of the Army Medical Research Acquisition Activity IL-6 Receptor Isoforms and Ovarian Cancer Progression Role:PI $250,000.00 Completed Type:Grant Level:National

Grant: #SRS 006039 Investigators:Waltz, Susan 01-01-2009 -12-31-2009 Shriners Hospitals for Children - Cincinnati Ron Receptor Signaling in Acute Lung Disease Role:PI $159,147.00 Completed Type:Grant Level:National

Grant: #SRS 006080 Investigators:Waltz, Susan 12-18-2008 -12-17-2010 Biogen Idec Inc. Test Whether Anti-muRON Antibodies Block RON Dependent Tumor Growth in Orthotopic, Syngeneic Animal Models Where both the Tumor and Host Express RON Role:PI $100,000.00 Completed Type:Contract

Grant: #KG080540 Investigators:Waltz, Susan; Wang, Shao-Chun 10-23-2008 -10-22-2011 Susan G. Komen Breast Cancer Foundation Tyrosine Phosphorylation and Functional Regulation of PCNA in Breast Cancer Role:Collaborator $600,000.00 Completed Type:Grant Level:National

Grant: #W81XWH-08-1-0443 Investigators:Ho, Shuk Mei; Waltz, Susan; Wang, Shao-Chun 09-02-2008 -09-01-2012 Department of the Army Medical Research Acquisition Activity Regulation of PCNA Function by Tyrosine Phosphorylation in Prostate Cancer Role:Collaborator $350,369.00 Completed Type:Grant Level:National

Grant: #R01 CA125379 Investigators:Collins, Margaret; Ho, Shuk Mei; Knudsen, Karen; Lentsch, Alex; Waltz, Susan 09-01-2008 -07-31-2014 National Cancer Institute The Ron Receptor/Chemokine Axis in Prostate Cancer Role:PI $1,275,379.00 Active Level:Federal

Grant: #8950 Investigators:Susan E. Waltz 01-01-2007 -12-31-2009 Shriners Hospitals for Children Ron receptor signaling in acute lung injury. Role:PI Completed Type:Grant Level:National

Grant: #1 T32 CA117846-01A1 Investigators:Waltz, Susan 09-01-2006 -08-31-2017 National Cancer Institute Training Program in Cancer Therapeutics Role:PI $1,895,938.00 Active Type:Grant Level:National

Grant: #R01 DK073552 Investigators:Waltz, Susan 09-15-2005 -06-30-2011 National Inst of Diabetes and Digestive and Kidney Disease Hepatocyte Growth Factor-like Protein Role:PI $1,486,771.00 Completed Type:Grant Level:National

Grant: #R01 DK73552 Investigators:Susan E. Waltz 09-15-2005 -06-30-2010 NIH/NIDDK The Hepatocyte Growth Factor-Like Protein Receptor Role:PI Completed Type:Grant Level:National

Grant: #R01 CA100002 Investigators:Susan E. Waltz 06-01-2004 -05-31-2009 NIH/NCI The Ron Receptor in Mammary Gland Biology Role:PI Completed Type:Grant Level:National

Grant: #R01 CA100002 Investigators:Waltz, Susan 06-01-2004 -04-30-2010 National Cancer Institute The Ron Receptor in Mammary Gland Biology Role:PI $1,456,066.00 Completed Type:Grant Level:National

Grant: #DAMD07-02-1-0342 Investigators:Waltz, Susan 04-01-2004 -09-30-2007 Department of the Army Medical Research and Materiel Command RON in Breast Cancer Development Role:PI $189,090.00 Completed Type:Grant Level:National

Investigators:Waltz, Susan 07-01-2003 -04-30-2006 National Inst of Diabetes and Digestive and Kidney Disease The Biology of Ron, the HGF-like Protein Receptor Role:PI $54,604.00 Completed Type:Grant Level:National

Grant: #T32 DK064581 Investigators:Susan E. Waltz 07-01-2003 -06-30-2008 NIH/NIDDK Research in Alimentary Tract Surgery Role:PI Completed Type:Grant Level:National

Investigators:Waltz, Susan 07-01-2003 -06-30-2005 National Institute of Child Health and Human Development The Hepatocyte Growth Factor-Like Protein Receptor Role:PI $211,153.00 Completed Type:Grant Level:National

Grant: #T32 DK064581 Investigators:Matthews, Jeffrey; Waltz, Susan 07-01-2003 -06-30-2008 National Inst of Diabetes and Digestive and Kidney Disease Research in Alimentary Tract Surgery Role:PI $1,052,600.00 Completed Type:Grant Level:National

Grant: #CCHMC Billing Agreement - T32HL125204 Investigators:Waltz, Susan; Witcher, Phillip 06-01-2020 -05-31-2021 National Heart, Lung and Blood Institute Understanding Cardiovascular Disease Mechanisms Role:PI $34,174.00 Awarded Level:Federal

Investigators:Waltz, Susan 07-01-2021 -03-31-2022 Department of Veterans Affairs Ron Receptor Tyrosine Kinase Signaling in Breast Cancer Role:PI 24007.50 Hold Level:Federal

Grant: #F31HL158185-01A1 Investigators:Romano, Laurel; Waltz, Susan 04-01-2022 -03-31-2024 National Heart, Lung and Blood Institute Effects of Erythropoietin on Bone Marrow Stroma Role:PI 43448.00 Awarded Level:Federal

Grant: #CCHMC 906513 01-01-2022 -12-31-2023 American Heart Association - National Chapter AHA (CCHMC Award# 906513) - Billing Agreement for Zhiyun Yu - Title: Elucidate the abnormal phenotypes of coronary arterial endothelial cells in Hypoplastic Left Heart Syndrome Role:PI 26590.00 Awarded Level:Non Profit

Grant: #CCHMC 906513 01-01-2022 -12-31-2023 American Heart Association - National Chapter AHA (CCHMC Award# 906513) - Billing Agreement for Zhiyun Yu - Title: Elucidate the abnormal phenotypes of coronary arterial endothelial cells in Hypoplastic Left Heart Syndrome Role:PI 26590.00 Awarded Level:Non Profit

Grant: #VA billing agreement for Levi Fox Investigators:Fox, Levi; Waltz, Susan 10-01-2022 -09-30-2024 Department of Veterans Affairs VA Billing Agreement for Levi Fox Role:PI 66801.00 Hold Level:Federal

07-01-2023 -06-30-2025 Department of Veterans Affairs VA Billing Agreement Lu (Waltz Merit) Role:PI 71676.00 Awarded Level:Federal

07-01-2023 -06-30-2025 Department of Veterans Affairs VA Billing Agreement Lu (Waltz Merit) Role:PI 71676.00 Awarded Level:Federal

Grant: #Kids Beating Cancer Investigators:Ishikawa, Chiharu; Waltz, Susan 05-15-2023 -09-30-2023 Kids Beating Cancer UBE2N is a Druggable Target and an Essential Ubiquitin-Conjugating Enzyme in Acute Myeloid Leukemia Role:PI 7000.00 Awarded Level:Non Profit

Grant: #Billing agreement for Wherley; T32HL125204-09 01-01-2024 -05-31-2024 National Heart, Lung and Blood Institute CCHMC - T32HL125204-09Billing Agreement: Wherley Role:PI 17999.00 Hold Level:Federal

Grant: #Billing agreement for Wherley; T32HL125204-09 01-01-2024 -05-31-2024 National Heart, Lung and Blood Institute CCHMC - T32HL125204-09Billing Agreement: Wherley Role:PI 17999.00 Hold Level:Federal

Grant: #T32CA298951 04-01-2025 -03-31-2030 National Cancer Institute Training Program in Basic and Translational Oncology Role:PI 0.00 Hold Level:Federal

Grant: #T32CA298951 04-01-2025 -03-31-2030 National Cancer Institute Training Program in Basic and Translational Oncology Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Hunt, Brian G; Wicker, Christina A; Bourn, Jennifer R; Lower, Elyse E; Takiar, Vinita; Waltz, Susan E (2020. ) MST1R (RON) expression is a novel prognostic biomarker for metastatic progression in breast cancer patients.Breast cancer research and treatment, , More Information

Sullivan, Camille; Brown, Nicholas E; Vasiliauskas, Juozas; Pathrose, Peterson; Starnes, Sandra L; Waltz, Susan E (2020. ) Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression.Molecular cancer research : MCR, , More Information

Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette (2020. ) DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages.Cancers, , 12 (7 ) , More Information

Babicky, Michele L; Harper, Megan M; Chakedis, Jeffery; Cazes, Alex; Mose, Evangeline S; Jaquish, Dawn V; French, Randall P; Childers, Betzaira; Alakus, Hakan; Schmid, Michael C; Foubert, Phillippe; Miyamoto, Jaclyn; Holman, Patrick J; Walterscheid, Zakkary J; Tang, Chih-Min; Varki, Nissi; Sicklick, Jason K; Messer, Karen; Varner, Judith A; Waltz, Susan E; Lowy, Andrew M (2019. ) MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages.Oncogene, , More Information

Ge, Chunmin; Vilfranc, Chrystelle L; Che, Lixiao; Pandita, Raj K; Hambarde, Shashank; Andreassen, Paul R; Niu, Liang; Olowokure, Olugbenga; Shah, Shimul; Waltz, Susan E; Zou, Lee; Wang, Jiang; Pandita, Tej K; Du, Chunying (2019. ) The BRUCE-ATR signaling axis is required for accurate DNA replication and suppression of liver cancer development.Hepatology (Baltimore, Md.), , More Information

Brown, Nicholas E; Sullivan, Camille; Waltz, Susan E (2018. ) Therapeutic Considerations for Ron Receptor Expression in Prostate Cancer. EMS cancer science journal, , 1 (1 ) ,

Modur, Vishnu; Singh, Navneet; Mohanty, Vakul; Chung, Eunah; Muhammad, Belal; Choi, Kwangmin; Chen, Xiaoting; Chetal, Kashish; Ratner, Nancy; Salomonis, Nathan; Weirauch, Matthew T; Waltz, Susan; Huang, Gang; Privette-Vinnedge, Lisa; Park, Joo-Seop; Janssen, Edith M; Komurov, Kakajan (2018. ) Defective transcription elongation in a subset of cancers confers immunotherapy resistance.Nature communications, , 9 (1 ) ,4410 More Information

Brown, Nicholas E; Paluch, Andrew M; Nashu, Madison A; Komurov, Kakajan; Waltz, Susan E (2018. ) Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation.Neoplasia (New York, N.Y.), , 20 (9 ) ,917-929 More Information

Ruiz-Torres S.;Benight N.;Karns R.;Lower E.;Guan J.;Waltz S. (01-01-2017. ) HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canoni.Oncotarget, , 8 (35 ) ,58918-58933 More Information

Ruiz-Torres, Sasha J; Benight, Nancy M; Karns, Rebekah A; Lower, Elyse E; Guan, Jun-Lin; Waltz, Susan E (2017. ) HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical ?-catenin signaling.Oncotarget, , 8 (35 ) ,58918-58933 More Information

Zhou, Zilan; Kennell, Carly; Jafari, Mina; Lee, Joo-Youp; Ruiz-Torres, Sasha J; Waltz, Susan E; Lee, Jing-Huei (2017. ) Sequential Delivery of Erlotinib and Doxorubicin for Enhanced Triple Negative Breast Cancer Treatment Using Polymeric Nanoparticle.International journal of pharmaceutics, , More Information

Ruiz-Torres, Sasha J; Benight, Nancy M; Karns, Rebekah A; Lower, Elyse E; Guan, Jun-Lin; Waltz, Susan E (2017. ) HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling.Oncotarget, , 8 (35 ) ,58918-58933 More Information

Zhou, Zilan; Jafari, Mina; Sriram, Vishnu; Kim, Jinsoo; Lee, Joo-Youp; Ruiz-Torres, Sasha J; Waltz, Susan E (2017. ) Delayed Sequential Co-Delivery of Gefitinib and Doxorubicin for Targeted Combination Chemotherapy.Molecular pharmaceutics, , 14 (12 ) ,4551-4559 More Information

Hunt, Brian G; Wang, Yuan-Liang; Chen, Min-Shan; Wang, Shao-Chun; Waltz, Susan E (2017. ) Maternal diethylhexyl phthalate exposure affects adiposity and insulin tolerance in offspring in a PCNA-dependent manner.Environmental research, , 159 ,588-594 More Information

Andrade, Kelsi; Fornetti, Jaime; Zhao, Ling; Miller, Scott C; Randall, R Lor; Anderson, Neysi; Waltz, Susan E; McHale, Mark; Welm, Alana L (2017. ) RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis.Science translational medicine, , 9 (374 ) , More Information

Benight, Nancy M; Wagh, Purnima K; Zinser, Glendon M; Peace, Belinda E; Stuart, William D; Vasiliauskas, Juozas; Pathrose, Peterson; Starnes, Sandra L; Waltz, Susan E (2015. ) HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses. Oncotarget, , 6 (19 ) ,17445-61

Johnson, Abby L; Zinser, Glendon M; Waltz, Susan E (2015. ) Vitamin D3-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of Beta-catenin activity .Oncotarget, , 6 (18 ) ,16304-20

Stuart, William D; Brown, Nicholas E; Paluch, Andrew M; Waltz, Susan E (2015. ) Loss of Ron receptor signaling leads to reduced obesity, diabetic phenotypes and hepatic steatosis in response to high fat diet in mice.American journal of physiology. Endocrinology and metabolism, , 308 (7 ) ,E562-72 More Information

Vasiliauskas, Juozas; Nashu, Madison A; Pathrose, Peterson; Starnes, Sandra L; Waltz, Susan E (2014. ) Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model. Oncotarget, , 5 (14 ) ,5547-58

Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I (2014. ) The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.Oncogene, , 34 (18 ) ,2325-36 More Information

Kulkarni, Rishikesh M; Stuart, William D; Waltz, Susan E (2014. ) Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia. Hepatobiliary & pancreatic diseases international : HBPD INT, , 13 (3 ) ,281-92

Zhao H., Chen MS, Lo Y-H, Waltz SE, Wang J, Ho P-C, Vasiliauskas J, Plattner R, Wang YL, Wang SC (2014. ) The RON receptor tyrosine kinase activates c-ABL to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer.Oncogene, , 33 (11 ) ,1429-37 More Information

Kulkarni, Rishikesh M; Stuart, William D; Gurusamy, Devikala; Waltz, Susan E (2014. ) Ron receptor signaling is protective against DSS-induced colitis in mice.American journal of physiology. Gastrointestinal and liver physiology, , 306 (12 ) ,G1065-74 More Information

Johnson, Abby L; Zinser, Glendon M; Waltz, Susan E (2014. ) Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development.American journal of physiology. Endocrinology and metabolism, , 307 (8 ) ,E674-85 More Information

Gurusamy, Devikala; Ruiz-Torres, Sasha J; Johnson, Abby L; Smith, Dana A; Waltz, Susan E (2014. ) Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.Mechanisms of development, , 133 ,11-22 More Information

Cai, Yuqi; Balli, David; Ustiyan, Vladimir; Fulford, Logan; Hiller, Andrea; Misetic, Vinko; Zhang, Yufang; Paluch, Andrew M; Waltz, Susan E; Kasper, Susan; Kalin, Tanya V (2013. ) Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis.The Journal of biological chemistry, , 288 (31 ) ,22527-41 More Information

Eyob, Henok; Ekiz, Huseyin Atakan; Derose, Yoko S; Waltz, Susan E; Williams, Matthew A; Welm, Alana L (2013. ) Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity.Cancer discovery, , 3 (7 ) ,751-60 More Information

Zhao, H; Chen, M-S; Lo, Y-H; Waltz, S E; Wang, J; Ho, P-C; Vasiliauskas, J; Plattner, R; Wang, Y-L; Wang, S-C (2013. ) The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer.Oncogene, , 33 (11 ) ,1429-37 More Information

Gurusamy, Devikala; Gray, Jerilyn K; Pathrose, Peterson; Kulkarni, Rishikesh M; Finkleman, Fred D; Waltz, Susan E (2013. ) Myeloid-specific expression of Ron receptor kinase promotes prostate tumor growth.Cancer research, , 73 (6 ) ,1752-63 More Information

Huitema, Leonie F A; Renn, Jörg; Logister, Ive; Gray, Jerilyn K; Waltz, Susan E; Flik, Gert; Schulte-Merker, Stefan (2012. ) Macrophage-stimulating protein and calcium homeostasis in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 26 (10 ) ,4092-4101 More Information

Benight, Nancy M; Waltz, Susan E (2012. ) Ron receptor tyrosine kinase signaling as a therapeutic target.Expert opinion on therapeutic targets, , 16 (9 ) ,921-31 More Information

Kulkarni, Rishikesh M; Kutcher, Louis W; Stuart, William D; Carson, Daniel J; Leonis, Mike A; Waltz, Susan E (2012. ) Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure. Hepatobiliary & pancreatic diseases international : HBPD INT, , 11 (4 ) ,383-92

Wagh, Purnima K; Zinser, Glendon M; Gray, Jerilyn K; Shrestha, Archana; Waltz, Susan E (2012. ) Conditional deletion of ?-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis.Endocrinology, , 153 (6 ) ,2735-46 More Information

Marshall, Aaron M; McClaine, Rebecca J; Gurusamy, Devikala; Gray, Jerilyn K; Lewnard, Kara E; Khan, Sohaib A; Waltz, Susan E (2012. ) Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice.Molecular cancer, , 11 ,2 More Information

Gray, Jerilyn K; Paluch, Andrew M; Stuart, William D; Waltz, Susan E (2012. ) Ron receptor overexpression in the murine prostate induces prostate intraepithelial neoplasia.Cancer letters, , 314 (1 ) ,92-101 More Information

Thobe, M N; Gray, J K; Gurusamy, D; Paluch, A M; Wagh, P K; Pathrose, P; Lentsch, A B; Waltz, S E (2011. ) The Ron receptor promotes prostate tumor growth in the TRAMP mouse model.Oncogene, , 30 (50 ) ,4990-8 More Information

Nikolaidis, Nikolaos M; Kulkarni, Rishikesh M; Gray, Jerilyn K; Collins, Margaret H; Waltz, Susan E (2011. ) Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung.Innate immunity, , 17 (6 ) ,499-507 More Information

Wagh, P K; Gray, J K; Zinser, G M; Vasiliauskas, J; James, L; Monga, S P; Waltz, S E (2011. ) β-Catenin is required for Ron receptor-induced mammary tumorigenesis.Oncogene, , 30 (34 ) ,3694-704 More Information

Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I (2011. ) The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer.Oncogene, , 30 (24 ) ,2741-52 More Information

Stuart, William D; Kulkarni, Rishikesh M; Gray, Jerilyn K; Vasiliauskas, Juozas; Leonis, Mike A; Waltz, Susan E (2011. ) Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in mice.Hepatology (Baltimore, Md.), , 53 (5 ) ,1618-28 More Information

Welsh, JoEllen; Zinser, Lindsay N; Mianecki-Morton, Laurel; Martin, Jamie; Waltz, Susan E; James, Howard; Zinser, Glendon M (2011. ) Age-related changes in the epithelial and stromal compartments of the mammary gland in normocalcemic mice lacking the vitamin D3 receptor.PloS one, , 6 (1 ) ,e16479 More Information

Zhao, Huajun; Lo, Yuan-Hung; Ma, Li; Waltz, Susan E; Gray, Jerilyn K; Hung, Mien-Chie; Wang, Shao-Chun (2011. ) Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth.Molecular cancer therapeutics, , 10 (1 ) ,29-36 More Information

McClaine R.;Marshall A.;Wagh P.;Waltz S. (01-01-2010. ) Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines.Neoplasia, , 12 (8 ) ,650-658 More Information

Zhao H.;Ou-Yang F.;Chen I.F.;Hou M.F.;Yuan S.S.F.;Chang H.L.;Lee Y.C.;Plattner R.;Waltz S.E.;Ho S.M.;Sims J.;Wang S.C. (01-01-2010. ) Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer.Neoplasia, , 12 (3 ) ,214-223 More Information

Jiang, Pingping; Hu, Qiuping; Ito, Mitsuhiro; Meyer, Sara; Waltz, Susan; Khan, Sohaib; Roeder, Robert G; Zhang, Xiaoting (2010. ) Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation.Proceedings of the National Academy of Sciences of the United States of America, , 107 (15 ) ,6765-70 More Information

Meyer, Sara E; Peace, Belinda E; Bahassi, El Mustapha; Kavanaugh, Gina M; Wagh, Purnima K; Robbins, Susan B; Yin, Moying; Wells, Susanne I; Zinser, Glendon M; Stambrook, Peter J; Waltz, Susan E (2010. ) Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.Cancer letters, , 296 (2 ) ,186-93 More Information

McClaine, Rebecca J; Marshall, Aaron M; Wagh, Purnima K; Waltz, Susan E (2010. ) Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines. Neoplasia (New York, N.Y.), , 12 (8 ) ,650-8

Zhao, Huajun; Ou-Yang, Fu; Chen, I-Fen; Hou, Ming-Feng; Yuan, Shyng-Shiou F; Chang, Hsueh-Ling; Lee, Yi-Chen; Plattner, Rina; Waltz, Susan E; Ho, Shuk-Mei; Sims, Jonathan; Wang, Shao-Chun (2010. ) Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer. Neoplasia (New York, N.Y.), , 12 (3 ) ,214-23

Logan-Collins, Jocelyn; Thomas, Ryan M; Yu, Peter; Jaquish, Dawn; Mose, Evangeline; French, Randall; Stuart, William; McClaine, Rebecca; Aronow, Bruce; Hoffman, Robert M; Waltz, Susan E; Lowy, Andrew M (2010. ) Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers.Cancer research, , 70 (3 ) ,1130-40 More Information

Nikolaidis, Nikolaos M; Gray, Jerilyn K; Gurusamy, Devikala; Fox, William; Stuart, William D; Huber, Nathan; Waltz, Susan E (2010. ) Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production.Shock (Augusta, Ga.), , 33 (2 ) ,197-204 More Information

Thobe, M N; Gurusamy, D; Pathrose, P; Waltz, S E (2010. ) The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells.Oncogene, , 29 (2 ) ,214-26 More Information

Meyer, Sara E; Waltz, Susan E; Goss, Kathleen H (2009. ) The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice.Molecular carcinogenesis, , 48 (11 ) ,995-1004 More Information

Meyer, Sara E; Zinser, Glendon M; Stuart, William D; Pathrose, Peterson; Waltz, Susan E (2009. ) The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis.Developmental biology, , 333 (1 ) ,173-85 More Information

Caldwell, Charles C; Martignoni, Andre; Leonis, Mike A; Ondiveeran, Hari Kumar; Fox-Robichaud, Alison E; Waltz, Susan E (2008. ) Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis.Critical care medicine, , 36 (5 ) ,1585-93 More Information

Wagh, Purnima K; Peace, Belinda E; Waltz, Susan E (2008. ) Met-related receptor tyrosine kinase Ron in tumor growth and metastasis.Advances in cancer research, , 100 ,1-33 More Information

Leonis, Mike A; Thobe, Megan N; Waltz, Susan E (2007. ) Ron-receptor tyrosine kinase in tumorigenesis and metastasis.Future oncology (London, England), , 3 (4 ) ,441-8 More Information

Thomas, Ryan M; Toney, Kenya; Fenoglio-Preiser, Cecilia; Revelo-Penafiel, Monica P; Hingorani, Sunil R; Tuveson, David A; Waltz, Susan E; Lowy, Andrew M (2007. ) The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.Cancer research, , 67 (13 ) ,6075-82 More Information

Lentsch, Alex B; Pathrose, Peterson; Kader, Sarah; Kuboki, Satoshi; Collins, Margaret H; Waltz, Susan E (2007. ) The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation.Shock (Augusta, Ga.), , 27 (3 ) ,274-80 More Information

Wetzel, Cynthia C; Leonis, Mike A; Dent, Arlene; Olson, Meredith A; Longmeier, Angela M; Ney, Paul A; Boivin, Greg P; Kader, Sarah A; Caldwell, Charles C; Degen, Sandra J F; Waltz, Susan E (2007. ) Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 292 (1 ) ,G253-61 More Information

Chan, Edward L; Peace, Belinda E; Toney, Kenya; Kader, Sarah A; Pathrose, Peterson; Collins, Margaret H; Waltz, Susan E (2007. ) Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis.Molecular carcinogenesis, , 46 (1 ) ,49-59 More Information

Wetzel, C. C.; Leonis, M. A.; Dent, A.; Olson, M. A.; Longmeier, A. M.; Ney, P. A.; Boivin, G. P.; Kader, S. A.; Caldwell, C. C.; Degen, S. J.; Waltz, S. E. (2007. ) Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury .Am J Physiol Gastrointest Liver Physiol, , 292 (1 ) ,G253-61

Thomas, R. M.; Toney, K.; Fenoglio-Preiser, C.; Revelo-Penafiel, M. P.; Hingorani, S. R.; Tuveson, D. A.; Waltz, S. E.; Lowy, A. M. (2007. ) The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression .Cancer Res, , 67 (13 ) ,6075-82

Leonis, M. A.; Thobe, M. N.; Waltz, S. E. (2007. ) Ron-receptor tyrosine kinase in tumorigenesis and metastasis .Future Oncol, , 3 (4 ) ,441-8

Lentsch, A. B.; Pathrose, P.; Kader, S.; Kuboki, S.; Collins, M. H.; Waltz, S. E. (2007. ) The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation .Shock, , 27 (3 ) ,274-80

Chan, E. L.; Peace, B. E.; Toney, K.; Kader, S. A.; Pathrose, P.; Collins, M. H.; Waltz, S. E. (2007. ) Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis .Mol Carcinog, , 46 (1 ) ,49-59

Zinser, G. M.; Leonis, M. A.; Toney, K.; Pathrose, P.; Thobe, M.; Kader, S. A.; Peace, B. E.; Beauman, S. R.; Collins, M. H.; Waltz, S. E. (2006. ) Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation .Cancer Res, , 66 (24 ) ,11967-74

Shen, H.; Schuster, R.; Stringer, K. F.; Waltz, S. E.; Lentsch, A. B. (2006. ) The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth .FASEB J, , 20 (1 ) ,59-64

Shen, H.; Schuster, R.; Lu, B.; Waltz, S. E.; Lentsch, A. B. (2006. ) Critical and opposing roles of the chemokine receptors CXCR2 and CXCR3 in prostate tumor growth .Prostate, , 66 (16 ) ,1721-8

O'Toole, J. M.; Rabenau, K. E.; Burns, K.; Lu, D.; Mangalampalli, V.; Balderes, P.; Covino, N.; Bassi, R.; Prewett, M.; Gottfredsen, K. J.; Thobe, M. N.; Cheng, Y.; Li, Y.; Hicklin, D. J.; Zhu, Z.; Waltz, S. E.; Hayman, M. J.; Ludwig, D. L.; Pereira, D. S. (2006. ) Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member .Cancer Res, , 66 (18 ) ,9162-70

Mallakin, A.; Kutcher, L. W.; McDowell, S. A.; Kong, S.; Schuster, R.; Lentsch, A. B.; Aronow, B. J.; Leikauf, G. D.; Waltz, S. E. (2006. ) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury .Am J Respir Cell Mol Biol, , 34 (1 ) ,15-27

Zinser, Glendon M; Leonis, Mike A; Toney, Kenya; Pathrose, Peterson; Thobe, Megan; Kader, Sarah A; Peace, Belinda E; Beauman, Shirelyn R; Collins, Margaret H; Waltz, Susan E (2006. ) Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation.Cancer research, , 66 (24 ) ,11967-74 More Information

Shen, Hui; Schuster, Rebecca; Lu, Bao; Waltz, Susan E; Lentsch, Alex B (2006. ) Critical and opposing roles of the chemokine receptors CXCR2 and CXCR3 in prostate tumor growth.The Prostate, , 66 (16 ) ,1721-8 More Information

O'Toole, Jennifer M; Rabenau, Karen E; Burns, Kerri; Lu, Dan; Mangalampalli, Venkat; Balderes, Paul; Covino, Nicole; Bassi, Rajiv; Prewett, Marie; Gottfredsen, Kimberly J; Thobe, Megan N; Cheng, Yuan; Li, Yiwen; Hicklin, Daniel J; Zhu, Zhenping; Waltz, Susan E; Hayman, Michael J; Ludwig, Dale L; Pereira, Daniel S (2006. ) Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member.Cancer research, , 66 (18 ) ,9162-70 More Information

Mallakin, Ali; Kutcher, Louis W; McDowell, Susan A; Kong, Sue; Schuster, Rebecca; Lentsch, Alex B; Aronow, Bruce J; Leikauf, George D; Waltz, Susan E (2006. ) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury.American journal of respiratory cell and molecular biology, , 34 (1 ) ,15-27 More Information

Shen, Hui; Schuster, Rebecca; Stringer, Keith F; Waltz, Susan E; Lentsch, Alex B (2006. ) The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 20 (1 ) ,59-64 More Information

Tsutsui, Shigeki; Noorbakhsh, Farshid; Sullivan, Andrea; Henderson, Andrew J; Warren, Kenneth; Toney-Earley, Kenya; Waltz, Susan E; Power, Christopher (2005. ) RON-regulated innate immunity is protective in an animal model of multiple sclerosis.Annals of neurology, , 57 (6 ) ,883-95 More Information

Peace, Belinda E; Toney-Earley, Kenya; Collins, Margaret H; Waltz, Susan E (2005. ) Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer.Cancer research, , 65 (4 ) ,1285-93 More Information

Chan, Edward L; Peace, Belinda E; Collins, Margaret H; Toney-Earley, Kenya; Waltz, Susan E (2005. ) Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin carcinogenesis.Oncogene, , 24 (3 ) ,479-88 More Information

Tsutsui, S.; Noorbakhsh, F.; Sullivan, A.; Henderson, A. J.; Warren, K.; Toney-Earley, K.; Waltz, S. E.; Power, C. (2005. ) RON-regulated innate immunity is protective in an animal model of multiple sclerosis .Ann Neurol, , 57 (6 ) ,883-95

Peace, B. E.; Toney-Earley, K.; Collins, M. H.; Waltz, S. E. (2005. ) Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer .Cancer Res, , 65 (4 ) ,1285-93

Chan, E. L.; Peace, B. E.; Collins, M. H.; Toney-Earley, K.; Waltz, S. E. (2005. ) Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin carcinogenesis .Oncogene, , 24 (3 ) ,479-88

van den Akker, E.; van Dijk, T.; Parren-van Amelsvoort, M.; Grossmann, K. S.; Schaeper, U.; Toney-Earley, K.; Waltz, S. E.; Lowenberg, B.; von Lindern, M. (2004. ) Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors .Blood, , 103 (12 ) ,4457-65

van den Akker, Emile; van Dijk, Thamar; Parren-van Amelsvoort, Martine; Grossmann, Katja S; Schaeper, Ute; Toney-Earley, Kenya; Waltz, Susan E; Löwenberg, Bob; von Lindern, Marieke (2004. ) Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.Blood, , 103 (12 ) ,4457-65 More Information

Peace, Belinda E; Hill, Kara J; Degen, Sandra J F; Waltz, Susan E (2003. ) Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor. Experimental cell research, , 289 (2 ) ,317-25

Hess, Karla Ann; Waltz, Susan E; Toney-Earley, Kenya; Degen, Sandra J F (2003. ) The receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible nitric oxide synthase levels and ovulation. Fertility and sterility, , 80 Suppl 2 ,747-54

Wetzel, Cynthia C; Degen, Sandra J F; Waltz, Susan E (2003. ) Cis-acting elements in the hepatocyte growth factor-like protein gene regulate kidney and liver-specific expression in mice.DNA and cell biology, , 22 (5 ) ,293-301 More Information

Hess, Karla Ann; Waltz, Susan E; Chan, Edward L; Degen, Sandra J F (2003. ) Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.Biology of reproduction, , 68 (4 ) ,1267-75 More Information

Wetzel, C. C.; Degen, S. J.; Waltz, S. E. (2003. ) Cis-acting elements in the hepatocyte growth factor-like protein gene regulate kidney and liver-specific expression in mice .DNA Cell Biol, , 22 (5 ) ,293-301

Peace, B. E.; Hill, K. J.; Degen, S. J.; Waltz, S. E. (2003. ) Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor .Exp Cell Res, , 289 (2 ) ,317-25

Hess, K. A.; Waltz, S. E.; Toney-Earley, K.; Degen, S. J. (2003. ) The receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible nitric oxide synthase levels and ovulation .Fertil Steril, , 80 Suppl 2 (2 ) ,747-54

Hess, K. A.; Waltz, S. E.; Chan, E. L.; Degen, S. J. (2003. ) Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function .Biol Reprod, , 68 (4 ) ,1267-75

McDowell, S. A.; Mallakin, A.; Bachurski, C. J.; Toney-Earley, K.; Prows, D. R.; Bruno, T.; Kaestner, K. H.; Witte, D. P.; Melin-Aldana, H.; Degen, S. J.; Leikauf, G. D.; Waltz, S. E. (2002. ) The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury .Am J Respir Cell Mol Biol, , 26 (1 ) ,99-104

Leonis, M. A.; Toney-Earley, K.; Degen, S. J.; Waltz, S. E. (2002. ) Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure .Hepatology, , 36 (5 ) ,1053-60

Leonis, Mike A; Toney-Earley, Kenya; Degen, Sandra J F; Waltz, Susan E (2002. ) Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure.Hepatology (Baltimore, Md.), , 36 (5 ) ,1053-60 More Information

McDowell, Susan A; Mallakin, Ali; Bachurski, Cindy J; Toney-Earley, Kenya; Prows, Daniel R; Bruno, Theresa; Kaestner, Klaus H; Witte, David P; Melin-Aldana, Hector; Degen, Sandra J F; Leikauf, George D; Waltz, Susan E (2002. ) The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. American journal of respiratory cell and molecular biology, , 26 (1 ) ,99-104

Peace, B E; Hughes, M J; Degen, S J; Waltz, S E (2001. ) Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis.Oncogene, , 20 (43 ) ,6142-51 More Information

Waltz, S E; Eaton, L; Toney-Earley, K; Hess, K A; Peace, B E; Ihlendorf, J R; Wang, M H; Kaestner, K H; Degen, S J (2001. ) Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses.The Journal of clinical investigation, , 108 (4 ) ,567-76 More Information

Waltz, S. E.; Eaton, L.; Toney-Earley, K.; Hess, K. A.; Peace, B. E.; Ihlendorf, J. R.; Wang, M. H.; Kaestner, K. H.; Degen, S. J. (2001. ) Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses .J Clin Invest, , 108 (4 ) ,567-76

Peace, B. E.; Hughes, M. J.; Degen, S. J.; Waltz, S. E. (2001. ) Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis .Oncogene, , 20 (43 ) ,6142-51

Waltz, S.; Stephani, U. (2000. ) Inheritance of photosensitivity .Neuropediatrics, , 31 (2 ) ,82-5

Waltz, S.; Pohlmann-Eden, B. (1999. ) [Anticonvulsant drug therapy in children and adults. Practical guide for single and multiple dosage] .Fortschr Neurol Psychiatr, , 67 (3 ) ,122-30

Muraoka, R. S.; Waltz, S. E.; Degen, S. J. (1999. ) Expression of hepatocyte growth factor-like protein is repressed by retinoic acid and enhanced by cyclic adenosine 3',5'-monophosphate response element-binding protein (CREB)-binding protein (CBP) .Endocrinology, , 140 (1 ) ,187-96

Muraoka, R. S.; Sun, W. Y.; Colbert, M. C.; Waltz, S. E.; Witte, D. P.; Degen, J. L.; Friezner Degen, S. J. (1999. ) The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse .J Clin Invest, , 103 (9 ) ,1277-85

Muraoka, R S; Sun, W Y; Colbert, M C; Waltz, S E; Witte, D P; Degen, J L; Friezner Degen, S J (1999. ) The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.The Journal of clinical investigation, , 103 (9 ) ,1277-85 More Information

Muraoka, R S; Waltz, S E; Degen, S J (1999. ) Expression of hepatocyte growth factor-like protein is repressed by retinoic acid and enhanced by cyclic adenosine 3',5'-monophosphate response element-binding protein (CREB)-binding protein (CBP). Endocrinology, , 140 (1 ) ,187-96

Trivedi, A; Waltz, S E; Kamath, S; Leffak, M (1998. ) Multiple initiations in the c-myc replication origin independent of chromosomal location. DNA and cell biology, , 17 (10 ) ,885-96

Waltz, S E; Toms, C L; McDowell, S A; Clay, L A; Muraoka, R S; Air, E L; Sun, W Y; Thomas, M B; Degen, S J (1998. ) Characterization of the mouse Ron/Stk receptor tyrosine kinase gene.Oncogene, , 16 (1 ) ,27-42 More Information

Degen, S J; McDowell, S A; Waltz, S E; Gould, F; Stuart, L A; Carritt, B (1998. ) Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein. DNA sequence : the journal of DNA sequencing and mapping, , 8 (6 ) ,409-13

Waltz, S. E.; Toms, C. L.; McDowell, S. A.; Clay, L. A.; Muraoka, R. S.; Air, E. L.; Sun, W. Y.; Thomas, M. B.; Degen, S. J. (1998. ) Characterization of the mouse Ron/Stk receptor tyrosine kinase gene .Oncogene, , 16 (1 ) ,27-42

Trivedi, A.; Waltz, S. E.; Kamath, S.; Leffak, M. (1998. ) Multiple initiations in the c-myc replication origin independent of chromosomal location .DNA Cell Biol, , 17 (10 ) ,885-96

Degen, S. J.; McDowell, S. A.; Waltz, S. E.; Gould, F.; Stuart, L. A.; Carritt, B. (1998. ) Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein .DNA Seq, , 8 (6 ) ,409-13

Waltz, S. E.; McDowell, S. A.; Muraoka, R. S.; Air, E. L.; Flick, L. M.; Chen, Y. Q.; Wang, M. H.; Degen, S. J. (1997. ) Functional characterization of domains contained in hepatocyte growth factor-like protein .J Biol Chem, , 272 (48 ) ,30526-37

Waltz, S E; McDowell, S A; Muraoka, R S; Air, E L; Flick, L M; Chen, Y Q; Wang, M H; Degen, S J (1997. ) Functional characterization of domains contained in hepatocyte growth factor-like protein. The Journal of biological chemistry, , 272 (48 ) ,30526-37

Waltz, S E; Trivedi, A A; Leffak, M (1996. ) DNA replication initiates non-randomly at multiple sites near the c-myc gene in HeLa cells. Nucleic acids research, , 24 (10 ) ,1887-94

Waltz, S E; Gould, F K; Air, E L; McDowell, S A; Degen, S J (1996. ) Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein. The Journal of biological chemistry, , 271 (15 ) ,9024-32

Waltz, S. E.; Trivedi, A. A.; Leffak, M. (1996. ) DNA replication initiates non-randomly at multiple sites near the c-myc gene in HeLa cells .Nucleic Acids Res, , 24 (10 ) ,1887-94

Waltz, S. E.; Gould, F. K.; Air, E. L.; McDowell, S. A.; Degen, S. J. (1996. ) Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein .J Biol Chem, , 271 (15 ) ,9024-32

McWhinney, C; Waltz, S E; Leffak, M (1995. ) Cis-acting effects of sequences within 2.4-kb upstream of the human c-myc gene on autonomous plasmid replication in HeLa cells. DNA and cell biology, , 14 (7 ) ,565-79

Bourn, Jennifer R; Ruiz-Torres, Sasha J; Hunt, Brian G; Benight, Nancy M; Waltz, Susan E (2021. ) Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling.Cancer letters, , 503 ,75-90 More Information

Wicker, Christina A; Hunt, Brian G; Krishnan, Sunil; Aziz, Kathryn; Parajuli, Shobha; Palackdharry, Sarah; Elaban, William R; Wise-Draper, Trisha M; Mills, Gordon B; Waltz, Susan E; Takiar, Vinita (2021. ) Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.Cancer letters, , 502 ,180-188 More Information

Pease N.A.; Shephard M.S.; Sertorio M.; Waltz S.E.; Privette Vinnedge L.M. (07-01-2020. ) Dek expression in breast cancer cells leads to the alternative activation of tumor associated macrop.Cancers, , 12 (7 ) ,1-21 More Information

Bourn J.R.; Ruiz-Torres S.J.; Hunt B.G.; Benight N.M.; Waltz S.E. (04-10-2021. ) Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhib.Cancer Letters, , 503 ,75-90 More Information

Ruiz-Torres, Sasha J; Bourn, Jennifer R; Benight, Nancy M; Hunt, Brian G; Lester, Carissa; Waltz, Susan E (2022. ) Macrophage-mediated RON signaling supports breast cancer growth and progression through modulation of IL-35.Oncogene, , 41(3) (Jan ) ,321-333 More Information

Hunt, Brian G; Jones, Angelle; Lester, Carissa; Davis, James C; Benight, Nancy M; Waltz, Susan E (2022. ) RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.Cancers, , 14 (10 ) , More Information

Brown, Nicholas E; Jones, Angelle; Hunt, Brian G; Waltz, Susan E (2022. ) Prostate tumor RON receptor signaling mediates macrophage recruitment to drive androgen deprivation therapy resistance through Gas6-mediated Axl and RON signaling.The Prostate, , More Information

Vicente-Muñoz, Sara; Hunt, Brian G; Lange, Taylor E; Wells, Susanne I; Waltz, Susan E (2022. ) NMR-based metabolomic analysis identifies RON-DEK-?-catenin dependent metabolic pathways and a gene signature that stratifies breast cancer patient survival.PloS one, , 17 (9 ) ,e0274128 More Information

Hunt B.G.; Jones A.; Lester C.; Davis J.C.; Benight N.M.; Waltz S.E. (05-01-2022. ) RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Pa.Cancers, , 14 (10 ) , More Information

Hunt, Brian G; Fox, Levi H; Davis, James C; Jones, Angelle; Lu, Zhixin; Waltz, Susan E (2023. ) An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling.Genes, , 14 (2 ) , More Information

Oropeza, Elena; Seker, Sinem; Carrel, Sabrina; Mazumder, Aloran; Lozano, Daniel; Jimenez, Athena; VandenHeuvel, Sabrina N; Noltensmeyer, Dillon A; Punturi, Nindo B; Lei, Jonathan T; Lim, Bora; Waltz, Susan E; Raghavan, Shreya A; Bainbridge, Matthew N; Haricharan, Svasti (2023. ) Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness.Science advances, , 9 (26 ) ,eadf2860 More Information

Hunt, Brian G; Davis, James C; Fox, Levi H; Vicente-Muñoz, Sara; Lester, Carissa; Wells, Susanne I; Waltz, Susan E (2023. ) RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence.Oncogene, , 42 (21 ) ,1716-1727 More Information

Davis, James C; Waltz, Susan E (2024. ) The MET Family of Receptor Tyrosine Kinases Promotes a Shift to Pro-Tumor Metabolism.Genes, , 15 (7 ) , More Information

Hazra, Aditi; Goldstein, Karen M; Waltz, Susan E; Chiba, Akiko; Colonna, Sarah V; Kelley, Michael J; Moss, Haley A; Zullig, Leah L (2024. ) Summary and Roadmap of Breast Cancer Research in the Veterans Affairs.Military medicine, , More Information

Davis, James C; Waltz, Susan E (2024. ) The MET Family of Receptor Tyrosine Kinases Promotes a Shift to Pro-Tumor Metabolism.Genes, , 15 (7 ) , More Information

Hazra, Aditi; Goldstein, Karen M; Waltz, Susan E; Chiba, Akiko; Colonna, Sarah V; Kelley, Michael J; Moss, Haley A; Zullig, Leah L (2024. ) Summary and Roadmap of Breast Cancer Research in the Veterans Affairs.Military medicine, , More Information

Davis, James C; Waltz, Susan E (2024. ) The MET Family of Receptor Tyrosine Kinases Promotes a Shift to Pro-Tumor Metabolism.Genes, , 15 (7 ) , More Information

Hazra, Aditi; Goldstein, Karen M; Waltz, Susan E; Chiba, Akiko; Colonna, Sarah V; Kelley, Michael J; Moss, Haley A; Zullig, Leah L (2024. ) Summary and Roadmap of Breast Cancer Research in the Veterans Affairs.Military medicine, , More Information

Korns, Julianna; Wicker, Christina A; Lehn, Maria; Shyamsunder, Shreya; Thompson, Samuel; Lester, Carissa; Wise-Draper, Trisha M; Waltz, Susan E; Takiar, Vinita (2024. ) Telaglenastat as an alternative to cisplatin as a radiosensitizer in the treatment of head and neck squamous cell carcinoma.Cancer letters, , 217320 More Information

Vicente-Muñoz, Sara; Davis, James C; Lane, Adam; Lane, Andrew N; Waltz, Susan E; Wells, Susanne I (2024. ) Lipid profiling of RON and DEK-dependent signaling in breast cancer guides discovery of gene networks predictive of poor outcomes.Frontiers in oncology, , 14 ,1382986 More Information

Korns, Julianna; Wicker, Christina A; Lehn, Maria; Shyamsunder, Shreya; Thompson, Samuel; Lester, Carissa; Wise-Draper, Trisha M; Waltz, Susan E; Takiar, Vinita (2024. ) Telaglenastat as an alternative to cisplatin as a radiosensitizer in the treatment of head and neck squamous cell carcinoma.Cancer letters, , 217320 More Information

Vicente-Muñoz, Sara; Davis, James C; Lane, Adam; Lane, Andrew N; Waltz, Susan E; Wells, Susanne I (2024. ) Lipid profiling of RON and DEK-dependent signaling in breast cancer guides discovery of gene networks predictive of poor outcomes.Frontiers in oncology, , 14 ,1382986 More Information

Book Chapter

Purnima Wagh, Belinda E. Peace, Susan E. Waltz Advances in Cancer Research-Volume 101 The Met-Related Receptor Tyrosine Kinase Ron in Tumor Growth and Metastasis .Amsterdam, Netherlands, Elsevier Science (Author)

Megan N. Thobe and Susan E. Waltz (2008 ) Encyclopedia of Cancer. 2nd Edition Ron Receptor .New York, Springer

Invited Presentations

Susan E. Waltz (04-23-2007. ) “The Ron Receptor Tyrosine Kinase in Breast Development and Cancer.” .New York, Stony Brook University. Level:National

Susan E. Waltz (11-02-2006. ) “The Ron Receptor Tyrosine Kinase in Mammary Biology.” .Biogen Idec, Cambridge, MA. Level:National

Susan E. Waltz (10-12-2006. ) “The Ron Receptor Tyrosine Kinase in Mammary Biology.” .McGill University Cancer Centre, Montreal, Quebec . Level:International

Susan E. Waltz (05-16-2006. ) “In vivo significance of Ron Receptor Signaling in Tumorigenesis and Metastasis.” .Genentech Inc, South San Francisco, CA. Level:National

Susan E. Waltz (03-29-2006. ) “Ron Receptor Signaling in Mammary Tumorigenesis and Metastasis.” .ImClone Systems Incorporated, New York, NY . Level:National

Susan E. Waltz (11-2013. ) Tumor cell autonomous and non cell autonomous signaling through the Ron receptor in cancer .University of Kentucky,

Susan E. Waltz (02-21-2006. ) “Ron Receptor Signaling in Tumorigenesis and Metastasis.” .Eli Lilly and Company, , Indianapolis, IN, . Level:National

Susan E. Waltz (2005. ) “Regulation of mammary gland tumorigenesis by the Ron receptor tyrosine kinas.” Invited Speaker, . FASEB Summer Research Conferences, Growth Factor Receptor Tyrosine Kinases in Mitogenesis, Morphogenesis, and Tumorigenesis. , Tucson, Arizona. Level:National

Susan E. Waltz (07-2012. ) The wRONg path to prostate cancer: Ron receptor function during tumorigenesis .FASEB Summer Conference on Tyrosine Kinase Signaling in Cancer, Disease and Development, Snowmass Village Colorado.

Susan E. Waltz (05-2010. ) BMS to Success .Wright State University,

Susan E. Waltz (10-2008. ) Ron and Mammary Biology .University of Nebraska Medical Center, Eppley Cancer Center, Omaha, NE.

Susan E. Waltz (04-2008. ) The Ron Receptor Signaling Axis in Breast Development and Cancer .Pfizer, La Jolla, CA.

Susan E. Waltz (04-2008. ) The Ron Receptor/Chemokine Signaling Axis in Prostate Cancer .American Association of Cancer Research Annual Meeting, San Diego, CA.

Susan Waltz (01-28-2019. ) The role of the Ron receptor tyrosine kinase in breast cancer .Case Western Reserve University, Cleveland, OH. Level:National

Susan Waltz (03-2018. ) The Ron path to cancer development .Wright State University, Dayton, OH. Level:National

Susan Waltz (11-2017. ) Ron mediated cross-talk promotes breast tumorigenesis through coordinated signaling in the breast cancer microenvironment.” Cincinnati Children’s Hospital Medical Center Immunohematology Seminar Series .Cincinnati, OH. Level:Regional

Signaling in the breast tumor microenvironment .Indiana University School of Medicine and Simon Cancer Center, Bloomington, IN. Level:National

Susan Waltz (03-2017. ) Ron receptor signaling promotes breast tumorigenesis through cooperative effects on cells in the tumor microenvironment .University of Texas Health Science Center at Houston. The Brown Foundation Institute of Molecular Medicine, Houston, TX. Level:National

Susan Waltz (11-2006. ) Coordinated signaling in the breast cancer microenvironment .Jensen Symposium Presentation, Cincinnati, OH. Level:National

2008 Ad Hoc Reviewer, National Institutes of Health Tumor Promotion and Metastasis Study Section Level:National

2007 Ad Hoc Reviewer, National Institutes of Health Hepatobiliary Pathophysiology Study Section Level:National

2006 Member Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program - Cell Biology 3. Level:National

2006 Scientific Reviewer 2006 Breast Cancer Research Program - Concept Award Peer Review Program-Cell Biology 3 Level:National

2005 Member, Congressionally Directed Medical Research Programs (CDMRP) Concept Award Peer Review Panel, Pathobiology 1.

2004 Member, 2004 Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program - Pathobiology 3 Level:National

2004 Member, National American Cancer Society, Cell Cycle and Growth Control Study Section, June 1999-2004. Level:National

1999 Basil O’Connor Award, March of Dimes. February 1, 1999-January 31, 2001 Level:National

1999 Scientist Development Award, American Heart Association-National Center. January 1, 1999-December 31, 2002 Level:National

1996 National Research Service Award (NRSA), Postdoctoral Fellowship, National Institutes of Health. July 1996-June 1997 Level:National

2007 Member, Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program - Pathobiology 2 Level:National

Oncogene, Journal of Biological Chemistry, Biochemistry, Liver, Development, Cancer Research, Biochemica et Biophyscia Acta, Annuals of Surgical Oncology, Journal of Cellular Physiology, J Immunology, Carcinogenesis, Gastroentrology, European Journal of Cancer. Peer Review/Referee 1997 -To Present

MST1R, hepatocyte growth factor like protein, HGFL, Met receptor, Ron receptor, tyrosine kinase, macrophage stimulating protein, hepatocyte growth factor, breast cancer, pancreatic cancer, liver cancer, prostate cacner, skin cancer, sepsis, liver failure, macrophage, chemokines

2006 -To Present: Member American Association of Cancer Research

2003 -To Present: Member Digestive Disease Research Development Center

2005 -To Present: Member Endocrine Society

1990 -To Present: Member American Association for the Advancement of Science

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267-0521
Phone: 513-558-8675
susan.waltz@uc.edu