Peter Walzer

Peter D Walzer

Emeritus

Medical Sciences Building

COM IM Infectious Diseases Division - 0560

Division of Infect Dis, Univ Cincinnati Coll Med
231 Albert Sabin Way
Cincinnati, Ohio 45267-0560

Professional Summary

Dr. Walzer has long been recognized internationally as a leader in Pneumocystis research. His studies have mainly focused on immunopathogenesis and therapy of the infection. He is board certified in Internal Medicine and Infectious Diseases, and has been elected to membership in the American College of Physicians (Fellow), Infectious Disease Society of America (Fellow), American Federation for Clinical Research, Central Society for Clinical Research, American Society for Microbiology, American Association for the Advancement of Science, American Society for Tropical Medicine and Hygiene, American Society for Parasitologists, American Thoracic Society, Society for Experimental Biology and Medicine, American Association of Immunologists and Sigma Xi. Dr. Walzer was awarded the Faculty Achievement Award from the University of Cincinnati in 1997. He  spent 2005-2006 at the London School of Hygiene and Tropical Medicine pursing a MSc Epidemiology to be better able to apply his basic research findings to HIV patients and other human populations. His published works include approximately 146 original publications, four books, 83 chapters, reviews, editorials and letters and 158 abstracts and presented papers.  In 2012, he received the Lifetime Achievement Award from the International Workshop on Opportunistic Protisit for his Pneumocystis achievements. 

Education

B.S., Boston College Chestnut Hill, Massachusetts, 1964

M.D., Albany Medical College Albany, New York, 1968

MSc., London School of Hygiene and Tropical Medicine 2006

Positions and Work Experience

1976 -1980 Assistant Professor of Medicine, University of Kentucky College of Medicine, Lexington, KY

1980 -1981 Associate Professor of Medicine, University of Kentucky College of Medicine, Lexington, KY

1976 -1981 Staff Physician, Infectious Diseases VA Medical Center, Lexington, KY

1981 -1985 Associate Professor of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1981 -1985 Associate Professor of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1981 -1984 Co-Chief, Infectious Diseases, VA Medical Center, Cincinnati, OH

1984 -2000 Chief, Infectious Diseases, VA Medical Center, Cincinnati, OH

1994 -2012 Associate Chief of Staff for Research, VA Medical Center, Cincinnati, OH

1985 -2012 Professor of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1986 -2012 Professor of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1988 -2012 Professor of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH

1994 -2005 Associate Chairman for Research, University of Cincinnati College of Medicine, Cincinnati, OH

2008 -2012 Professor of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH

2012 - Emeritus Professor of Medicine, University of Cincinnati,

Research and Practice Interests

Clinical Interests: infections in HIV patients and immunocompromised host, parasitology and tropical medicine

Research Interests: Pneumocystis infections: immunology, pathogenesis, treatment

Research Support

Grant: #R01 A1-06492 2005 -2011 National Institutes of Health Research Grant Serum Antibodies to Recombinant Pneumocystis Antigens Role:P.I.

Grant: #R01 HL-090335 2007 -2012 National Institutes of Health Research Grant International HIV Associated Lung Infections and Complications Role:Co-I

Grant: #HHSN272201000029I 2010 -2017 National Institutes of Health Contract Animal models of Infectious Diseases Role:P.I.

Grant: #R01 AI062492 Investigators:Walzer, Peter 09-15-2005 -02-28-2011 National Institute of Allergy and Infectious Diseases Serum Antibodies to Recombinant Pneumocystis Antigens Role:PI $2,037,064.00 Closed Level:Federal

Grant: #5-U01-AI-38858-04-A0-S0-E0 Investigators:Walzer, Peter 05-28-1999 -05-27-2001 National Institute of Allergy and Infectious Diseases Recombinant Antigen(s) Derived from Human Pneumocystis carinii Role:PI $64,260.00 Closed Level:Federal

Grant: #N01-AI-25467 Investigators:Walzer, Peter 06-28-2002 -12-27-2009 National Institute of Allergy and Infectious Diseases Drug Development for Opportunistic Infections - Pneumocystis Carinii Pneumonia Role:PI $3,174,868.00 Closed Level:Federal

Grant: #5-N01-AI-75319-05-A0-S0-E0 Investigators:Walzer, Peter 09-01-1997 -08-31-2002 National Institute of Allergy and Infectious Diseases Preclinical Evaluation of Therapies for PC Infection Role:PI $1,524,275.00 Closed Level:Federal

Grant: #5-R01-HL-64570-05-A0-S0-E0 Investigators:Walzer, Peter 04-01-2000 -03-31-2009 National Heart, Lung and Blood Institute SP-A Mouse Models of Pneumocystis Infection Role:PI $1,911,500.00 Closed Level:Federal

Grant: #UCSF 4914sc / HL090335 Investigators:Walzer, Peter 09-23-2007 -06-30-2013 National Heart, Lung and Blood Institute International HIV-Associated Opportunistic Pneumonias (IHOP) Study Role:PI $543,177.00 Active Level:Federal

Grant: #K23 AI080202 Investigators:Robertson, Jaime; Smulian, Alan; Walzer, Peter 09-15-2008 -08-31-2013 National Institute of Allergy and Infectious Diseases Research Career Development in HIV-Related Anal Dysplasia/Carcinoma Prevention and Treatment Role:Collaborator $580,529.00 Active Level:Federal

Grant: #HHSN2722010000291 Investigators:Cushion, Melanie; Newman, Simon; Rhodes, Judith; Smulian, Alan; Walzer, Peter 03-22-2010 -03-21-2017 National Institute of Allergy and Infectious Diseases Animal Models of Infectious Diseases Role:Collaborator $1,333,752.00 Active Level:Federal

Publications

Peer Reviewed Publications

Gingo, Matthew R; Lucht, Lorrie; Daly, Kieran R; Djawe, Kpandja; Palella, Frank J; Abraham, Alison G; Bream, Jay H; Witt, Mallory D; Kingsley, Lawrence A; Norris, Karen A; Walzer, Peter D; Morris, Alison (2011. )Serologic responses to Pneumocystis Proteins in Human Immunodeficiency Virus Patients With and Without Pneumocystis jirovecii Pneumonia.Journal of acquired immune deficiency syndromes (1999), ,

Crothers, Kristina; Daly, Kieran R; Rimland, David; Goetz, Matthew Bidwell; Gibert, Cynthia L; Butt, Adeel A; Justice, Amy C; Djawe, Kpandja; Levin, Linda; Walzer, Peter D (2011. )Decreased serum antibody responses to recombinant pneumocystis antigens in HIV-infected and uninfected current smokers.Clinical and vaccine immunology : CVI, ,18 (3 ),380-6

Djawe, Kpandja; Huang, Laurence; Daly, Kieran R; Levin, Linda; Koch, Judy; Schwartzman, Alexandra; Fong, Serena; Roth, Brenna; Subramanian, Anuradha; Grieco, Katherine; Jarlsberg, Leah; Walzer, Peter D (2010. )Serum antibody levels to the Pneumocystis jirovecii major surface glycoprotein in the diagnosis of P. jirovecii pneumonia in HIV+ patients.PloS one, ,5 (12 ),e14259

Djawe, Kpandja; Daly, Kieran R; Vargas, Sergio L; Santolaya, M Elena; Ponce, Carolina A; Bustamante, Rebeca; Koch, Judith; Levin, Linda; Walzer, Peter D (2010. )Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, ,14 (12 ),e1060-6

Miller, R F; Evans, H E R; Copas, A J; Huggett, J F; Edwards, S G; Walzer, P D (2010. )Seasonal variation in mortality of Pneumocystis jirovecii pneumonia in HIV-infected patients.International journal of STD & AIDS, ,21 (7 ),497-503

Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D (2010. )Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection.PloS one, ,5 (1 ),e8524

Nkinin, Stephenson W; Daly, Kieran R; Walzer, Peter D; Ndzi, Edward S; Asonganyi, Tazoacha; Respaldiza, Nieves; Medrano, Francisco J; Kaneshiro, Edna S (2009. )Evidence for high prevalence of Pneumocystis jirovecii exposure among Cameroonians.Acta tropica, ,112 (2 ),219-24

Daly, K; Koch, J; Respaldiza, N; de la Horra, C; Montes-Cano, M A; Medrano, F J; Varela, J M; Calderon, E J; Walzer, P D (2009. )Geographical variation in serological responses to recombinant Pneumocystis jirovecii major surface glycoprotein antigens.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, ,15 (10 ),937-42

Tipirneni, Renuka; Daly, Kieran R; Jarlsberg, Leah G; Koch, Judy V; Swartzman, Alexandra; Roth, Brenna M; Walzer, Peter D; Huang, Laurence (2009. )Healthcare worker occupation and immune response to Pneumocystis jirovecii. Emerging infectious diseases, ,15 (10 ),1590-7

Walzer, Peter D; Djawe, Kpandja; Levin, Linda; Daly, Kieran R; Koch, Judith; Kingsley, Lawrence; Witt, Mallory; Golub, Elizabeth T; Bream, Jay H; Taiwo, Babafemi; Morris, Alison (2009. )Long-term serologic responses to the Pneumocystis jirovecii major surface glycoprotein in HIV-positive individuals with and without P. jirovecii infection.The Journal of infectious diseases, ,199 (9 ),1335-44

Linke, Michael J; Ashbaugh, Alan D; Demland, Jeffery A; Walzer, Peter D (2009. )Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure.Respiratory research, ,10 ,10

Cushion, Melanie T; Walzer, Peter D (2009. )Preclinical drug discovery for new anti-pneumocystis compounds. Current medicinal chemistry, ,16 (20 ),2514-30

Linke, Michael J; Ashbaugh, Alan A; Koch, Judith V; Levin, Linda; Tanaka, Reiko; Walzer, Peter D Effects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in mice.The Journal of eukaryotic microbiology, ,56 (1 ),58-65

Walzer, Peter D; Evans, Hannah E R; Copas, Andrew J; Edwards, Simon G; Grant, Alison D; Miller, Robert F (2008. )Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985-2006.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,46 (4 ),625-33

Daly, K R; Koch, J V; Shire, N J; Levin, L; Walzer, P D (2006. )Human immunodeficiency virus-infected patients with prior Pneumocystis pneumonia exhibit increased serologic reactivity to several major surface glycoprotein clones.Clinical and vaccine immunology : CVI, ,13 (10 ),1071-8

Daly, Kieran R; Huang, Laurence; Morris, Alison; Koch, Judy; Crothers, Kristina; Levin, Linda; Eiser, Shary; Satwah, Supriya; Zucchi, Patricia; Walzer, Peter D (2006. )Antibody response to Pneumocystis jirovecii major surface glycoprotein. Emerging infectious diseases, ,12 (8 ),1231-7

Cushion, Melanie T; Walzer, Peter D; Ashbaugh, Alan; Rebholz, Sandra; Brubaker, Ronald; Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L (2006. )In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.Antimicrobial agents and chemotherapy, ,50 (7 ),2337-43

Cushion, Melanie T; Walzer, Peter D; Collins, Margaret S; Rebholz, Sandra; Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L (2004. )Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds.Antimicrobial agents and chemotherapy, ,48 (11 ),4209-16

Morris, Alison; Lundgren, Jens D; Masur, Henry; Walzer, Peter D; Hanson, Debra L; Frederick, Toni; Huang, Laurence; Beard, Charles B; Kaplan, Jonathan E (2004. )Current epidemiology of Pneumocystis pneumonia. Emerging infectious diseases, ,10 (10 ),1713-20

Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L; Collins, Margaret S; Rebholz, Sandra; Walzer, Peter D; Cushion, Melanie T (2004. )Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.Bioorganic & medicinal chemistry letters, ,14 (17 ),4545-8

Daly, Kieran R; Koch, Judy; Levin, Linda; Walzer, Peter D (2004. )Enzyme-linked immunosorbent assay and serologic responses to Pneumocystis jiroveci. Emerging infectious diseases, ,10 (5 ),848-54

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D (2004. )Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids. Infection and immunity, ,72 (2 ),757-65

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D (2003. )New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies. Infection and immunity, ,71 (11 ),6292-7

Thullen, Timothy D; Walzer, Peter D (2003. )Large doses of major surface glycoprotein-sensitized donor splenocytes transferred to corticosteroid treated rats with Pneumocystis pneumonia result in successful reduction of organism burden. The Journal of eukaryotic microbiology, ,50 Suppl ,666-7

Daly, Kieran R; Fichtenbaum, Carl J; Tanaka, Reiko; Linke, Michael J; O'Bert, Robert; Thullen, Timothy D; Hui, Michele S; Smulian, Alan G; Walzer, Peter D (2002. )Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons.The Journal of infectious diseases, ,186 (5 ),644-51

Walzer, Peter D; Ashbaugh, Alan (2002. )Use of terbinafine in mouse and rat models of Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, ,46 (2 ),514-6

Walzer, P D; Ashbaugh, A; Collins, M; Cushion, M T (2001. )Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo.The Journal of infectious diseases, ,184 (10 ),1355-7

Walzer, P D; Ashbaugh, A; Collins, M; Cushion, M T (2001. )In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii.Antimicrobial agents and chemotherapy, ,45 (11 ),3234-7

Linke, M J; Harris, C E; Korfhagen, T R; McCormack, F X; Ashbaugh, A D; Steele, P; Whitsett, J A; Walzer, P D (2001. )Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.The Journal of infectious diseases, ,183 (6 ),943-52

Dohn, M N; White, M L; Vigdorth, E M; Ralph Buncher, C; Hertzberg, V S; Baughman, R P; George Smulian, A; Walzer, P D (2000. )Geographic clustering of Pneumocystis carinii pneumonia in patients with HIV infection. American journal of respiratory and critical care medicine, ,162 (5 ),1617-21

Walzer, P D (1999. )Immunological features of Pneumocystis carinii infection in humans. Clinical and diagnostic laboratory immunology, ,6 (2 ),149-55

Walzer, P D (1998. )Pneumocystis carinii: a historical perspective. Seminars in respiratory infections, ,13 (4 ),279-82

Theus, S A; Smulian, A G; Steele, P; Linke, M J; Walzer, P D (1998. )Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response. Vaccine, ,16 (11-12 ),1149-57

De Stefano, J A; Myers, J D; Du Pont, D; Foy, J M; Theus, S A; Walzer, P D Cell wall antigens of Pneumocystis carinii trophozoites and cysts: purification and carbohydrate analysis of these glycoproteins. The Journal of eukaryotic microbiology, ,45 (3 ),334-43

Broomall, K R; Morris, R E; Walzer, P D; Smulian, A G Zymolyase treatment exposes p55 antigen of Pneumocystis carinii. The Journal of eukaryotic microbiology, ,45 (3 ),284-9

Sunkin, S M; Linke, M J; McCormack, F X; Walzer, P D; Stringer, J R (1998. )Identification of a putative precursor to the major surface glycoprotein of Pneumocystis carinii. Infection and immunity, ,66 (2 ),741-6

Linke, M J; Sunkin, S M; Andrews, R P; Stringer, J R; Walzer, P D (1998. )Expression, structure, and location of epitopes of the major surface glycoprotein of Pneumocystis carinii f. sp. carinii. Clinical and diagnostic laboratory immunology, ,5 (1 ),50-7

Theus, S A; Sawhney, N; Smulian, A G; Walzer, P D (1998. )Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii. The Journal of infectious diseases, ,177 (1 ),238-41

Kaneshiro, E S; Walzer, P D Comments: overview of the 5th international workshop on Pneumocystis and the 5th general meeting of the European Concerted Action on Pneumocystis Research. The Journal of eukaryotic microbiology, ,44 (6 ),61S-63S

Theus, S A; Walzer, P D In vitro cytolytic activity of lymphocytes against Pneumocystis carinii. The Journal of eukaryotic microbiology, ,44 (6 ),25S-27S

Theus, S A; Walzer, P D Adoptive transfer of specific lymphocyte populations sensitized to the major surface glycoprotein of Pneumocystis carinii decreases organism burden while increasing survival rate in the rat. The Journal of eukaryotic microbiology, ,44 (6 ),23S-24S

Cushion, M T; Walzer, P D; Smulian, A G; Linke, M J; Ruffolo, J J; Kaneshiro, E S; Stringer, J R (1997. )Terminology for the life cycle of Pneumocystis carinii. Infection and immunity, ,65 (10 ),4365; author reply 4

Theus, S A; Smulian, A G; Sullivan, D W; Walzer, P D (1997. )Cytokine responses to the native and recombinant forms of the major surface glycoprotein of Pneumocystis carinii. Clinical and experimental immunology, ,109 (2 ),255-60

Walzer, P D (1997. )Pneumocystis carinii pneumonia in patients without human immunodeficiency virus infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,25 (2 ),219-20

McCormack, F X; Festa, A L; Andrews, R P; Linke, M; Walzer, P D (1997. )The carbohydrate recognition domain of surfactant protein A mediates binding to the major surface glycoprotein of Pneumocystis carinii.Biochemistry, ,36 (26 ),8092-9

Theus, S A; Andrews, R P; Linke, M J; Walzer, P D Characterization of rat CD4 T cell clones specific for the major surface glycoprotein of Pneumocystis carinii. The Journal of eukaryotic microbiology, ,44 (2 ),96-100

Walzer, P D; Runck, J; Steele, P; White, M; Linke, M J; Sidman, C L (1997. )Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs. Antimicrobial agents and chemotherapy, ,41 (2 ),251-8

Walzer, P D; Runck, J; Orr, S; Foy, J; Steele, P; White, M (1997. )Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: analysis of drug interactions and efficacies. Antimicrobial agents and chemotherapy, ,41 (2 ),242-50

Cushion, M T; Walzer, P D Closing comments: a retrospective perspective 4th International Workshop on Pneumocystis. The Journal of eukaryotic microbiology, ,43 (5 ),60S-61S

Stringer, J R; Walzer, P D (1996. )Molecular biology and epidemiology of Pneumocystis carinii infection in AIDS. AIDS (London, England), ,10 (6 ),561-71

Keely, S P; Stringer, J R; Baughman, R P; Linke, M J; Walzer, P D; Smulian, A G (1995. )Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. The Journal of infectious diseases, ,172 (2 ),595-8

Theus, S A; Andrews, R P; Steele, P; Walzer, P D (1995. )Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat.The Journal of clinical investigation, ,95 (6 ),2587-93

Smulian, A G; Linke, M J; Cushion, M T; Baughman, R P; Frame, P T; Dohn, M N; White, M L; Walzer, P D (1994. )Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity. AIDS (London, England), ,8 (11 ),1555-62

Walzer, P D; Foy, J; Runck, J; Steele, P; White, M; Klein, R S; Otter, B A; Sundberg, R J (1994. )Guanylhydrazones in therapy of Pneumocystis carinii pneumonia in immunosuppressed rats. Antimicrobial agents and chemotherapy, ,38 (11 ),2572-6

Linke, M J; Smulian, A G; Yoshihara, P; Walzer, P D Production and characterization of monoclonal antibodies specific for the major surface glycoprotein of Pneumocystis carinii. The Journal of eukaryotic microbiology, ,41 (5 ),99S-100S

Andrews, R P; Theus, S A; Cushion, M T; Walzer, P D Comparison of the antigenic recognition of the major surface glycoprotein of Pneumocystis carinii isolated from different rat strains. The Journal of eukaryotic microbiology, ,41 (5 ),72S

Theus, S A; Sullivan, D W; Walzer, P D; Smulian, A G (1994. )Cellular responses to a 55-kilodalton recombinant Pneumocystis carinii antigen. Infection and immunity, ,62 (8 ),3479-84

De Stefano, J A; Foy, J M; Sullivan, D W; Dawes, S M; Cushion, M T; Babcock, G F; Sleight, R G; van Halbeek, H; Walzer, P D (1994. )Fractionation of Pneumocystis carinii developmental stages by counterflow centrifugal elutriation and sequential filtrations. Parasitology research, ,80 (1 ),1-9

Linke, M J; Smulian, A G; Stringer, J R; Walzer, P D (1994. )Characterization of multiple unique cDNAs encoding the major surface glycoprotein of rat-derived Pneumocystis carinii. Parasitology research, ,80 (6 ),478-86

Rice, W R; Singleton, F M; Linke, M J; Walzer, P D (1993. )Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat.The Journal of clinical investigation, ,92 (6 ),2778-82

Theus, S A; Linke, M J; Andrews, R P; Walzer, P D (1993. )Proliferative and cytokine responses to a major surface glycoprotein of Pneumocystis carinii. Infection and immunity, ,61 (11 ),4703-9

Walzer, P D (1993. )Pneumocystis carinii: recent advances in basic biology and their clinical application. AIDS (London, England), ,7 (10 ),1293-305

Walzer, P D; Foy, J; Steele, P; White, M (1993. )Synergistic combinations of Ro 11-8958 and other dihydrofolate reductase inhibitors with sulfamethoxazole and dapsone for therapy of experimental pneumocystosis. Antimicrobial agents and chemotherapy, ,37 (7 ),1436-43

Smulian, A G; Sullivan, D W; Linke, M J; Halsey, N A; Quinn, T C; MacPhail, A P; Hernandez-Avila, M A; Hong, S T; Walzer, P D (1993. )Geographic variation in the humoral response to Pneumocystis carinii. The Journal of infectious diseases, ,167 (5 ),1243-7

Smulian, A G; Theus, S A; Denko, N; Walzer, P D; Stringer, J R (1993. )A 55 kDa antigen of Pneumocystis carinii: analysis of the cellular immune response and characterization of the gene. Molecular microbiology, ,7 (5 ),745-53

Walzer, P D; Foy, J; Steele, P; White, M (1992. )Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. Antimicrobial agents and chemotherapy, ,36 (9 ),1943-50

Walzer, P D; Foy, J; Steele, P; Kim, C K; White, M; Klein, R S; Otter, B A; Allegra, C (1992. )Activities of antifolate, antiviral, and other drugs in an immunosuppressed rat model of Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, ,36 (9 ),1935-42

De Stefano, J A; Trinkle, L S; Walzer, P D; Cushion, M T (1992. )Flow cytometric analyses of lectin binding to Pneumocystis carinii surface carbohydrates. The Journal of parasitology, ,78 (2 ),271-80

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D (1992. )Isolation and characterization of a recombinant antigen of Pneumocystis carinii. Infection and immunity, ,60 (3 ),907-15

Smulian, A G; Walzer, P D (1992. )The biology of Pneumocystis carinii.Critical reviews in microbiology, ,18 (3 ),191-216

De Stefano, J A; Sleight, R G; Babcock, G F; Sramkoski, R M; Walzer, P D (1992. )Isolation of Pneumocystis carinii cysts by flow cytometry. Parasitology research, ,78 (3 ),179-82

Smulian, A G; Stringer, J R; Linke, M J; Walzer, P D Expression cloning of Pneumocystis carinii antigens. The Journal of protozoology, ,38 (6 ),8S-10S

Linke, M J; Walzer, P D Identification and purification of a soluble species of gp120 released by zymolyase treatment of Pneumocystis carinii. The Journal of protozoology, ,38 (6 ),176S-178S

Walzer, P D Overview of animal models of Pneumocystis carinii pneumonia. The Journal of protozoology, ,38 (6 ),122S-123S

Walzer, P D (1991. )Immunopathogenesis of Pneumocystis carinii infection. The Journal of laboratory and clinical medicine, ,118 (3 ),206-16

Walzer, P D (1991. )Pneumocystis carinii--new clinical spectrum?.The New England journal of medicine, ,324 (4 ),263-5

Walzer, P D; Kim, C K; Foy, J; Zhang, J L (1991. )Furazolidone and nitrofurantoin in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, ,35 (1 ),158-63

Cushion, M T; Stringer, J R; Walzer, P D (1991. )Cellular and molecular biology of Pneumocystis carinii. International review of cytology, ,131 ,59-107

De Stefano, J A; Cushion, M T; Puvanesarajah, V; Walzer, P D Analysis of Pneumocystis carinii cyst wall. II. Sugar composition. The Journal of protozoology, ,37 (5 ),436-41

De Stefano, J A; Cushion, M T; Sleight, R G; Walzer, P D Analysis of Pneumocystis carinii cyst wall. I. Evidence for an outer surface membrane. The Journal of protozoology, ,37 (5 ),428-35

Hong, S T; Steele, P E; Cushion, M T; Walzer, P D; Stringer, S L; Stringer, J R (1990. )Pneumocystis carinii karyotypes. Journal of clinical microbiology, ,28 (8 ),1785-95

Peglow, S L; Smulian, A G; Linke, M J; Pogue, C L; Nurre, S; Crisler, J; Phair, J; Gold, J W; Armstrong, D; Walzer, P D (1990. )Serologic responses to Pneumocystis carinii antigens in health and disease. The Journal of infectious diseases, ,161 (2 ),296-306

Cushion, M T; Hong, S T; Steele, P E; Stringer, S L; Walzer, P D; Stringer, J R (1990. )Molecular biology of Pneumocystis carinii. Annals of the New York Academy of Sciences, ,616 ,415-20

Stringer, S L; Stringer, J R; Blase, M A; Walzer, P D; Cushion, M T (1989. )Pneumocystis carinii: sequence from ribosomal RNA implies a close relationship with fungi. Experimental parasitology, ,68 (4 ),450-61

Linke, M J; Cushion, M T; Walzer, P D (1989. )Properties of the major antigens of rat and human Pneumocystis carinii. Infection and immunity, ,57 (5 ),1547-55

Shultz, L D; Schweitzer, P A; Hall, E J; Sundberg, J P; Taylor, S; Walzer, P D (1989. )Pneumocystis carinii pneumonia in scid/scid mice. Current topics in microbiology and immunology, ,152 ,243-9

Walzer, P D; Kim, C K; Linke, M J; Pogue, C L; Huerkamp, M J; Chrisp, C E; Lerro, A V; Wixson, S K; Hall, E; Shultz, L D (1989. )Outbreaks of Pneumocystis carinii pneumonia in colonies of immunodeficient mice. Infection and immunity, ,57 (1 ),62-70

Kaneshiro, E S; Cushion, M T; Walzer, P D; Jayasimhulu, K Analyses of Pneumocystis fatty acids. The Journal of protozoology, ,36 (1 ),69S-72S

De Stefano, J A; Cushion, M T; Trinkle, L S; Walzer, P D Lectins as probes to Pneumocystis carinii surface glycocomplexes. The Journal of protozoology, ,36 (1 ),65S-66S

Linke, M J; Walzer, P D Analysis of a surface antigen of Pneumocystis carinii. The Journal of protozoology, ,36 (1 ),60S-61S

Ruffolo, J J; Cushion, M T; Walzer, P D Ultrastructural observations on life cycle stages of Pneumocystis carinii. The Journal of protozoology, ,36 (1 ),53S-54S

Stringer, S L; Hudson, K; Blase, M A; Walzer, P D; Cushion, M T; Stringer, J R Sequence from ribosomal RNA of Pneumocystis carinii compared to those of four fungi suggests an ascomycetous affinity. The Journal of protozoology, ,36 (1 ),14S-16S

Walzer, P D Historical perspectives on Pneumocystis carinii. The Journal of protozoology, ,36 (1 ),39-41

Cushion, M T; Blase, M A; Walzer, P D A method for isolation of RNA from Pneumocystis carinii. The Journal of protozoology, ,36 (1 ),12S-14S

Walzer, P D; Cushion, M T (1989. )Immunobiology of Pneumocystis carinii. Pathology and immunopathology research, ,8 (3-4 ),127-40

Cushion, M T; DeStefano, J A; Walzer, P D (1988. )Pneumocystis carinii: surface reactive carbohydrates detected by lectin probes. Experimental parasitology, ,67 (2 ),137-47

Hagler, D N; Deepe, G S; Pogue, C L; Walzer, P D (1988. )Blastogenic responses to Pneumocystis carinii among patients with human immunodeficiency (HIV) infection. Clinical and experimental immunology, ,74 (1 ),7-13

Walzer, P D; Kim, C K; Foy, J; Linke, M J; Cushion, M T (1988. )Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, ,32 (6 ),896-905

Carter, T R; Cooper, P H; Petri, W A; Kim, C K; Walzer, P D; Guerrant, R L (1988. )Pneumocystis carinii infection of the small intestine in a patient with acquired immune deficiency syndrome. American journal of clinical pathology, ,89 (5 ),679-83

Walzer, P D (1988. )Diagnosis of Pneumocystis carinii pneumonia. The Journal of infectious diseases, ,157 (4 ),629-32

Cushion, M T; Ruffolo, J J; Walzer, P D (1988. )Analysis of the developmental stages of Pneumocystis carinii, in vitro. Laboratory investigation; a journal of technical methods and pathology, ,58 (3 ),324-31

Walzer, P D; Kim, C K; Foy, J M; Linke, M J; Cushion, M T (1988. )Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, ,32 (1 ),96-103

Hagler, D N; Kim, C K; Walzer, P D (1987. )Feline leukemia virus and Pneumocystis carinii infection. The Journal of parasitology, ,73 (6 ),1284-6

Douce, R W; Brown, A E; Khamboonruang, C; Walzer, P D; Genta, R M (1987. )Seroepidemiology of strongyloidiasis in a Thai village. International journal for parasitology, ,17 (7 ),1343-8

Sullivan, R; Linneman, C C; Clark, C S; Walzer, P D (1987. )Seroepidemiologic study of giardiasis patients and high-risk groups in a midwestern city in the United States. American journal of public health, ,77 (8 ),960-3

Genta, R M; Weesner, R; Douce, R W; Huitger-O'Connor, T; Walzer, P D (1987. )Strongyloidiasis in US veterans of the Vietnam and other wars. JAMA : the journal of the American Medical Association, ,258 (1 ),49-52

Walzer, P D; Cushion, M T; Juranek, D; Walls, K; Armstrong, D; Gold, J; Young, L S; Pesanti, E; Graves, D C; Ivey, M B (1987. )Serology and P carinii. Chest, ,91 (6 ),935-6

Walzer, P D; Stanforth, D; Linke, M J; Cushion, M T (1987. )Pneumocystis carinii: immunoblotting and immunofluorescent analyses of serum antibodies during experimental rat infection and recovery. Experimental parasitology, ,63 (3 ),319-28

Walzer, P D; Linke, M J (1987. )A comparison of the antigenic characteristics of rat and human Pneumocystis carinii by immunoblotting. Journal of immunology (Baltimore, Md. : 1950), ,138 (7 ),2257-65

Kim, C K; Foy, J M; Cushion, M T; Stanforth, D; Linke, M J; Hendrix, H L; Walzer, P D (1987. )Comparison of histologic and quantitative techniques in evaluation of therapy for experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, ,31 (2 ),197-201

McCann, P P; Bacchi, C J; Clarkson, A B; Bey, P; Sjoerdsma, A; Schecter, P J; Walzer, P D; Barlow, J L (1986. )Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects. The American journal of tropical medicine and hygiene, ,35 (6 ),1153-6

McRury, J; De Messias, I T; Walzer, P D; Huitger, T; Genta, R M (1986. )Specific IgE responses in human strongyloidiasis. Clinical and experimental immunology, ,65 (3 ),631-8

Genta, R M; Douce, R W; Walzer, P D (1986. )Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis. Journal of clinical microbiology, ,23 (6 ),1099-103

Walzer, P D (1986. )Attachment of microbes to host cells: relevance of Pneumocystis carinii. Laboratory investigation; a journal of technical methods and pathology, ,54 (6 ),589-92

Ruffolo, J J; Cushion, M T; Walzer, P D (1986. )Techniques for examining Pneumocystis carinii in fresh specimens. Journal of clinical microbiology, ,23 (1 ),17-21

Cushion, M T; Stanforth, D; Linke, M J; Walzer, P D (1985. )Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro. Antimicrobial agents and chemotherapy, ,28 (6 ),796-801

Cushion, M T; Ruffolo, J J; Linke, M J; Walzer, P D (1985. )Pneumocystis carinii: growth variables and estimates in the A549 and WI-38 VA13 human cell lines. Experimental parasitology, ,60 (1 ),43-54

Walzer, P D; LaBine, M; Redington, T J; Cushion, M T (1984. )Predisposing factors in Pneumocystis carinii pneumonia: effects of tetracycline, protein malnutrition, and corticosteroids on hosts. Infection and immunity, ,46 (3 ),747-53

Walzer, P D; LaBine, M; Redington, T J; Cushion, M T (1984. )Lymphocyte changes during chronic administration of and withdrawal from corticosteroids: relation to Pneumocystis carinii pneumonia. Journal of immunology (Baltimore, Md. : 1950), ,133 (5 ),2502-8

Yoneda, K; Walzer, P D (1984. )The effect of corticosteroid treatment on the cell surface glycocalyx of the rat pulmonary alveolus: relevance to the host-parasite relationship in pneumocystis carinii infection. British journal of experimental pathology, ,65 (3 ),347-54

Cushion, M T; Walzer, P D (1984. )Growth and serial passage of Pneumocystis carinii in the A549 cell line. Infection and immunity, ,44 (2 ),245-51

Cushion, M T; Walzer, P D (1984. )Cultivation of Pneumocystis carinii in lung-derived cell lines. The Journal of infectious diseases, ,149 (4 ),644

Walzer, P D; Young, L S (1984. )Clinical relevance of animal models of Pneumocystis carinii pneumonia. Diagnostic microbiology and infectious disease, ,2 (1 ),1-6

Genta, R M; Ottesen, E A; Neva, F A; Walzer, P D; Tanowitz, H B; Wittner, M (1983. )Cellular responses in human strongyloidiasis. The American journal of tropical medicine and hygiene, ,32 (5 ),990-4

Rankin, J A; Walzer, P D; Dwyer, J M; Schrader, C E; Enriquez, R E; Merrill, W W (1983. )Immunologic alterations in bronchoalveolar lavage fluid in the acquired immunodeficiency syndrome (AIDS). The American review of respiratory disease, ,128 (1 ),189-94

Yoneda, K; Walzer, P D (1983. )Attachment of Pneumocystis carinii to type I alveolar cells studied by freeze-fracture electron microscopy. Infection and immunity, ,40 (2 ),812-5

Baughman, R P; Solinger, A; Hurtubise, P; Dohn, M N; Walzer, P D; Rashkin, M C; Dortin, D Bronchoalveolar lavage in patients with the acquired immune deficiency syndrome (AIDS). AIDS research, ,1 (2 ),91-7

Walzer, P D; Rutledge, M E; Yoneda, K (1983. )Experimental Pneumocystis carinii pneumonia in C3H/HeJ and C3HeB/FeJ mice. Journal of the Reticuloendothelial Society, ,33 (1 ),1-9

Girón, J A; Martinez, S; Walzer, P D (1982. )Should inpatients with Pneumocystis carinii be isolated? .Lancet, ,2 (8288 ),46

Walzer, P D; Milder, J E; Banwell, J G; Kilgore, G; Klein, M; Parker, R (1982. )Epidemiologic features of Strongyloides stercoralis infection in an endemic area of the United States. The American journal of tropical medicine and hygiene, ,31 (2 ),313-9

Yoneda, K; Walzer, P D; Richey, C S; Birk, M G (1982. )Pneumocystis carinii: freeze-fracture study of stages of the organism. Experimental parasitology, ,53 (1 ),68-76

Walzer, P D; Rutledge, M E (1982. )Serum antibody responses to Pneumocystis carinii among different strains of normal and athymic mice. Infection and immunity, ,35 (2 ),620-6

Yoneda, K; Walzer, P D (1981. )Mechanism of pulmonary alveolar injury in experimental Pneumocystis carinii pneumonia in the rat. British journal of experimental pathology, ,62 (4 ),339-46

Milder, J E; Walzer, P D; Kilgore, G; Rutherford, I; Klein, M (1981. )Clinical features of Strongyloides stercoralis infection in an endemic area of the United States. Gastroenterology, ,80 (6 ),1481-8

Walzer, P D; Rutledge, M E (1981. )Humoral immunity in experimental Pneumocystis carinii infection. I. Serum and bronchial lavage fluid antibody responses in rats. The Journal of laboratory and clinical medicine, ,97 (6 ),820-33

Stahr, B J; Walzer, P D; Yoneda, K (1981. )Effect of proteolytic enzymes on Pneumocystis carinii in rat lung tissue. The Journal of parasitology, ,67 (2 ),196-202

Walzer, P D (1981. )Intestinal parasitism in Kentucky: an important medical and public health problem. The Journal of the Kentucky Medical Association, ,79 (2 ),95-9

Walzer, P D; Rutledge, M E (1980. )Comparison of rat, mouse, and human Pneumocystis carinii by immunofluorescence. The Journal of infectious diseases, ,142 (3 ),449

Yoneda, K; Walzer, P D (1980. )Interaction of Pneumocystis carinii with host lungs: an ultrastructural study. Infection and immunity, ,29 (2 ),692-703

Walzer, P D; Armstrong, D; Weisman, P; Tan, C (1980. )Serum immunoglobulin levels in childhood Hodgkin's disease. Effect of splenectomy and long-term follow-up. Cancer, ,45 (8 ),2084-9

Milder, J E; Walzer, P D; Coonrod, J D; Rutledge, M E (1980. )Comparison of histological and immunological techniques for detection of Pneumocystis carinii in rat bronchial lavage fluid. Journal of clinical microbiology, ,11 (4 ),409-17

Walzer, P D; Powell, R D; Yoneda, K; Rutledge, M E; Milder, J E (1980. )Growth characteristics and pathogenesis of experimental Pneumocystis carinii pneumonia. Infection and immunity, ,27 (3 ),928-37

Milder, J E; Walzer, P D; Powell, R D (1979. )Treatment of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole and pentamidine: efficacy and toxicity. Southern medical journal, ,72 (12 ),1626-8

Milder, J E; McDearmon, S C; Walzer, P D (1979. )Presumed respiratory syncytial virus pneumonia in an adolescent compromised host. Southern medical journal, ,72 (9 ),1195-8

Gottschall, J L; Walzer, P D; Yoneda, K (1979. )The morphologic changes of the rat type II pneumocytes induced by oxytetracycline. Laboratory investigation; a journal of technical methods and pathology, ,41 (1 ),5-12

Walzer, P D; Rutledge, M E; Yoneda, K; Stahr, B J (1979. )Pneumocystis carinii: new separation method from lung tissue. Experimental parasitology, ,47 (3 ),356-68

Walzer, P D; Powell, R D; Yoneda, K (1979. )Experimental Pneumocystis carinii pneumonia in different strains of cortisonized mice. Infection and immunity, ,24 (3 ),939-47

Singer, C; Armstrong, D; Rosen, P P; Walzer, P D; Yu, B (1979. )Diffuse pulmonary infiltrates in immunosuppressed patients. Prospective study of 80 cases. The American journal of medicine, ,66 (1 ),110-20

Walzer, P D; Rutherford, I; East, R (1978. )Empyema with Trichomonas species. The American review of respiratory disease, ,118 (2 ),415-8

Walzer, P D (1977. )Pneumocystis carinii infection. Southern medical journal, ,70 (11 ),1330-7

Walzer, P D; Schnelle, V; Armstrong, D; Rosen, P P (1977. )Nude mouse: a new experimental model for Pneumocystis carinii infection. Science (New York, N.Y.), ,197 (4299 ),177-9

Walzer, P D; Armstrong, D Lymphogranuloma venereum presenting as superclavicular and inguinal lymphadenopathy. Sexually transmitted diseases, ,4 (1 ),12-4

Walzer, P D; Schultz, M G; Western, K A; Robbins, J F (1976. )Pneumocystis carinii pneumonia and primary immune deficiency diseases. National Cancer Institute monograph, ,43 ,65-74

Walzer, P D; Perl, D P; Krogstad, D J; Rawson, P G; Schultz, M G (1976. )Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features. National Cancer Institute monograph, ,43 ,55-63

Healy, G R; Walzer, P D; Sulzer, A J (1976. )A case of asymptomatic babesiosis in Georgia. The American journal of tropical medicine and hygiene, ,25 (3 ),376-8

Fu, S M; Winchester, R J; Feizi, T; Walzer, P D; Kunkel, H G (1974. )Idiotypic specificity of surface immunoglobulin and the maturation of leukemic bone-marrow-derived lymphocytes. Proceedings of the National Academy of Sciences of the United States of America, ,71 (11 ),4487-90

Walzer, P D; Kunkel, H G (1974. )The correlation of serum IgD concentration with Gm allotype. Journal of immunology (Baltimore, Md. : 1950), ,113 (1 ),274-8

Walzer, P D; Gibson, J J; Schultz, M G (1974. )Malaria fatalities in the United States. The American journal of tropical medicine and hygiene, ,23 (3 ),328-33

Walzer, P D; Perl, D P; Krogstad, D J; Rawson, P G; Schultz, M G (1974. )Pneumocystis carinii pneumonia in the United States. Epidemiologic, diagnostic, and clinical features. Annals of internal medicine, ,80 (1 ),83-93

Walzer, P D; Schultz, M G; Western, K A; Robbins, J B (1973. )Pneumocystis carinii pneumonia and primary immune deficiency diseases of infancy and childhood. The Journal of pediatrics, ,82 (3 ),416-22

Walzer, P D; Judson, F N; Murphy, K B; Healy, G R; English, D K; Schultz, M G (1973. )Balantidiasis outbreak in Truk. The American journal of tropical medicine and hygiene, ,22 (1 ),33-41

Beasley, J W; Walzer, P D (1972. )Ineffectiveness of metronidazole in treatment of Balantidium coli infections. Transactions of the Royal Society of Tropical Medicine and Hygiene, ,66 (3 ),519

Walzer, P D; Wolfe, M S; Schultz, M G (1971. )Giardiasis in travelers. The Journal of infectious diseases, ,124 (2 ),235-7

Honors and Awards

1984 -1986 Clinical Investigator, Veterans Administration

1997 Faculty Achievement Award, University of Cincinnati

2002 Association of American Physicians

2005 -2006 Career Development Enhancement Award, Department of Veterans Affairs

2005 -2006 National Research Serice Award, National Institutes of Health

Post Graduate Training and Education

1968-1969 Intern in Medicine, Mary Imogene Bassett Hospital, ,Cooperstown, New York

1969-1970 Resident in Medicine, Mary Imogene Bassett Hospital, ,Cooperstown, New York

1970-1972 Epidemic Intelligence Service Officer, Parasitic Diseases Branch, Epidemiology Program, Centers for Disease Control, USPHS, ,Atlanta, Georgia

1972-1974 Research Associate, Laboratory of Dr. Henry Kunkel, Assistant Resident Physician, Rockefeller University, ,New York, New York

1974-1975 Resident in Medicine, Memorial Sloan-Kettering Cancer Center, ,New York, New York

1975-1976 Fellow in Infectious Diseases, Memorial Sloan-Kettering Cancer Center, ,New York, New York

2005-2006 Sabbatical, MSc Epidemiology, London School of Hygiene and Tropical Medicine, ,United Kingdom

Keywords

infection, pathogen, Pneumocystis, HIV, immunocompromised host, parasitology, pneumonia, infectious diseases, fungus

Contact Information

Academic - Division of Infect Dis, Univ Cincinnati Coll Med
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0560
Phone: 513-558-4704
Peter.walzer@uc.edu