Chenran Wang

Chenran Wang

Assistant Professor

Vontz Center

3316

COM Cancer Biology - 0521

Vontz Center for Molecular Studies
Room 3316
Cincinnati, Ohio 45267

Research Support

Grant: #R03NS097887 Investigators:Guan, Jun-lin; Wang, Chenran 07-01-2016 -06-30-2018 National Institute of Neurological Disorders and Stroke Mechanisms of autophagy in TSC1-deficient neural stem cells Role:PI $79,000.00 Awarded Level:Federal

Grant: #R01NS103981 Investigators:Guan, Jun-lin; Wang, Chenran 07-15-2018 -06-30-2023 National Institute of Neurological Disorders and Stroke Regulation of lipid catabolism by autophagy in neural stem cell of tuberous sclerosis complex Role:PI $350,000.00 Active Level:Federal

Grant: #305627 sub 3R01AG053498-02S1 Investigators:Wang, Chenran 09-06-2018 -02-28-2019 National Institute on Aging Administrative supplement to metabolic alterations in age-associated dendritic cell function Role:PI $8,533.96 Active Level:Federal

Grant: #2019 Award Investigators:Wang, Chenran 01-01-2020 -12-31-2021 Local Initiative for Excellence (L.I.F.E.) Mechanisms of enhanced autophagy protecting healthy aging of neural stem cells Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #R01NS094144 Investigators:Guan, Jun-lin; Wang, Chenran 09-01-2020 -06-30-2025 National Institute of Neurological Disorders and Stroke Regulation of neural stem cells and neurogenesis by autophagy genes Role:Collaborator $396,034.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin (2018. )Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.Autophagy, ,14 (7 ),1214-1225

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin (2017. )Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.The Journal of cell biology, ,216 (8 ),2581-2596

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin (2016. )Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.Genes & development, ,30 (7 ),856-69

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. )Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, ,212 (5 ),545-60

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin (2015. )Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis.Breast cancer research and treatment, ,149 (3 ),619-29

Kim, Edward; Wang, Yuan; Kim, Sun-Jung; Bornhorst, Miriam; Jecrois, Emmanuelle S; Anthony, Todd E; Wang, Chenran; Li, Yi E; Guan, Jun-Lin; Murphy, Geoffrey G; Zhu, Yuan (2014. )Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.eLife, ,3 ,

Wei, Huijun; Wang, Chenran; Croce, Carlo M; Guan, Jun-Lin (2014. )p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.Genes & development, ,28 (11 ),1204-16

Wang, Chenran; Haas, Michael A., Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R.; Guan, Jun-Lin (11-11-2019. )Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells .Nature Metabolism, ,1, ,1127–1140

Deng, Shan; Essandoh, Kobina; Wang, Xiaohong; Li, Yutian; Huang, Wei; Chen, Jing; Peng, Jiangtong; Jiang, Ding-Sheng; Mu, Xingjiang; Wang, Chenran; Peng, Tianqing; Guan, Jun-Lin; Wang, Yigang; Jegga, Anil; Huang, Kai; Fan, Guo-Chang (2020. )Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.Redox biology, ,101453

Chen, Qixin; Shao, Xintian; Hao, Mingang; Fang, Hongbao; Guan, Ruilin; Tian, Zhiqi; Li, Miaoling; Wang, Chenran; Ji, Liangnian; Chao, Hui; Guan, Jun-Lin; Diao, Jiajie (2020. )Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy.Biomaterials, ,250 ,120059

Yang, Fuchun; Sun, Shaogang; Wang, Chenran; Haas, Michael; Yeo, Syn; Guan, Jun-Lin (2020. )Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.British journal of cancer, ,

Yeo, Syn Kok; Wang, Chenran; Guan, Jun-Lin (2020. )Role of FIP200 in inflammatory processes beyond its canonical autophagy function.Biochemical Society transactions, ,

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. )Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, ,1 (11 ),1127-1140

Contact Information

Academic - Vontz Center for Molecular Studies
Room 3316
Cincinnati  Ohio, 45267
Phone: (513) 558-4816
chenran.wang@uc.edu