Hong-Sheng Wang , PHD

Ion channels are pore-forming membrane proteins. Transmembrane ionic currents generated by ion channels are the basis of electrical activities of excitable tissues, including the heart. Alterations of ionic currents are a major factor in various cardiac diseases such as arrhythmias. We are interested in the role of ion channels in controlling the electrical and mechanical properties of cardiac cells. We are also interested in how alterations of ion channel expression and/or properties contribute to abnormal myocyte electrical and mechanical properties in various disease conditions such as heart failure and arrhythmias. We employ electrophysiology, protein chemistry and molecular biology techniques in the lab. In addition, we use mathematical modeling and the real-time dynamic clamp technique to address these questions. The later approach combines computer simulation with experimental biology, and allows us to simulate artificial ionic conductances in real, live cells. A second major focus of our lab is to understand both the acute effects of endogenous estrogen and environmental endocrine disrupters on the physiology of the heart and the role they play in cardiac diseases.

BS: University of Science and Technology of China 1986 (Biology)

PhD: State University of New York 1991 (Neurobiology)

Cardiovascular, Heart, Endocrine Disruptor, Environmental Health, Arrhythmias, Electrophysiology, Calcium Handling, Mechanism

2002 -To Present Assistant Professor, tenure track, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH

2002 -To Present Faculty member, Neuroscience Program, University of Cincinnati, College of Medicine, Cincinnati, OH

2000 -2002 Research Assistant Professor, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York

1997 -2000 Postdoctoral Fellow, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York

1998 - Grass Fellow, Marine Biological Laboratory, Woods Hole,

Grant: #R01 ES017263 Investigators:H-S Wang 06-2008 NIH/NIEHS/NHLBI “Effects of Environmental Estrogen Exposure on the Heart” Role:PI

Investigators:H-S Wang 07-01-2008 AHA (National) Innovative Research Grant “Role of ion channel remodeling in heart failure” Role:PI

Grant: #R01 HL075633 Investigators:JE Schultz, H-S Wang 11-01-2007 NIH/NHLBI “Signaling mechanisms of FGF2-induced cardioprotection” Role:Co-PI

Grant: #R01 HL61974 Investigators:G Shull, H-S Wang NIH/NHLBI “Mouse Models for Ion Homeostasis Defects in Heart” Role:Co-PI

Grant: #R21 HL084539 Investigators:H-S Wang 01-25-2007 -12-31-2008 NIH/NHLBI “Ionic Basis of the Brugada Syndrome” Role:PI

Grant: #R01 HL64018 Investigators:EG Kranias, H-S Wang 02-01-2007 -01-31-2010 NIH/NHLBI “Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins” Role:Co-PI

Grant: #P30 ES06096 Investigators:H-S Wang 04-01-2008 -04-01-2009 NIH/NIEHS “Sex-specific sensitivity of cardiac cells to estrogen and endocrine disruptors – the mechanistic role of differential expression of estrogen receptors” Role:PI

Grant: #0130023N Investigators:H-S Wang 01-01-2001 -12-31-2005 American Heart Association (National) “Regulation of the Cardiac Transient Outward Current by an Accessory Channel Subunit – KchIP2” Role:PI

Grant: #R21 HL084539 Investigators:Wang, Hongsheng 01-25-2007 -12-31-2009 National Heart, Lung and Blood Institute Ionic Basis of the Brugada Syndrome Role:PI $402,011.00 Closed Level:Federal

Grant: #0130023N-04-A0-S0-E0 Investigators:Wang, Hongsheng 04-01-2002 -12-31-2005 American Heart Association - National Chapter Regulation of the Cardiac Transient Outward Current by an Accessory Channel Subunit - KCh1P2 Role:PI $230,217.00 Closed Level:Private Non-Profit

Grant: #0715114B Investigators:Dong, Min; Wang, Hongsheng 07-01-2007 -06-30-2009 American Heart Association - Great Rivers Affiliate The Role of Transient Outward Current in Modulating Electrical and Mechanical Properties in Failing Ventricular Myocytes Role:Collaborator $21,000.00 Closed Level:Private Non-Profit

Grant: #R01 ES017263 Investigators:Wang, Hongsheng 08-01-2009 -04-30-2014 National Institute of Environmental Health Sciences Effects of Environmental Estrogen Exposure on the Heart Role:PI $1,734,707.00 Active Level:Federal

Grant: #2 R01 HL061974-10A1 Investigators:Lorenz, John; Shull, Gary; Wang, Hongsheng 09-01-2009 -08-31-2011 National Heart, Lung and Blood Institute Mouse Models for Ion Homeostasis Defects in Heart Role:Collaborator $1,111,765.00 Closed Level:Federal

Grant: #1 RC2 ES018765-01 Investigators:Belcher, Scott; Lorenz, John; Schultz, Jo El; Wang, Hongsheng 09-30-2009 -06-30-2013 National Institute of Environmental Health Sciences Defining the Impact of Dietary Bisphenol A on Heart Health in the C57BL/6 Mouse Role:Collaborator $1,428,319.00 Active Level:Federal

Grant: #R01 HL105176 Investigators:Ashraf, Muhammad; Jones, Walter; Wang, Hongsheng; Wang, Yi-Gang; Xu, Meifeng 09-10-2010 -05-31-2015 National Heart, Lung and Blood Institute Wnt11 Signaling in Stem Cell Survival and Cardiac Regeneration Role:Collaborator $1,532,098.00 Active Level:Federal

Grant: #EES 007270 Investigators:Wang, Hongsheng 12-20-2010 -12-31-2013 Ethicon Endo Surgery, Incorporated Injury in Response to and Protection from Acute and Chronic Hypoxemia Role:PI $49,500.00 Active Level:Industry

Grant: #R01 HL110740 Investigators:Ashraf, Muhammad; Millard, Ronald; Wang, Hongsheng; Wang, Yi-Gang; Xu, Meifeng 09-01-2011 -05-31-2016 National Heart, Lung and Blood Institute iPS Cells-Derived Progenitor Cells for Angiomyogenesis Role:Collaborator $1,435,966.00 Active Level:Federal

Grant: #R01ES027855 Investigators:Pinney, Susan; Rubinstein, Jack; Wang, Hongsheng; Xie, Changchun 02-01-2018 -01-31-2023 National Institute of Environmental Health Sciences Endocrine Disruptors and Heart Health Role:PI $429,032.00 Active Level:Federal

Grant: #CDC M-CRADA (Related to 1R01ES027855 / Coeus #011327-003) Investigators:Wang, Hongsheng 11-01-2018 -10-31-2019 Centers for Disease Control and Prevention MATERIALS COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT (Associated with R01ES027855) Role:PI $.00 Active Level:Federal

Grant: #134164 / T32HL125204 Investigators:Tucker, Latia; Wang, Hongsheng 01-14-2019 -11-30-2019 National Heart, Lung and Blood Institute Understanding Cardiovascular Disease Mechanisms - Billing agreement for Latia Tucker Role:PI $29,488.00 Awarded Level:Federal

Grant: #R01HL157456 Investigators:Fan, Guochang; Liang, Jialiang; Wang, Hongsheng; Wang, Yi-Gang 04-01-2021 -03-31-2025 National Heart, Lung and Blood Institute CRISPR-induced cardiovascular progenitor cells to repair myocardial infarction Role:Collaborator $623,215.00 Awarded Level:Federal

Grant: #S10OD030402 Investigators:Closson, Chet; Fan, Guochang; Hong, Christian; Luo, Yu; Sadayappan, Sakthivel; Wang, Hongsheng; Weiss, Alison; Zhang, Yuhang 09-01-2021 -08-31-2022 Office of the Director, National Institutes of Health Leica Stellaris 8 Confocal Microscope Role:Collaborator 598148.00 Awarded Level:Federal

Published Abstracts

Wang H-S and McKinnon D (1994. ) Potassium currents in prevertebral and paravertebral sympathetic neurons .[Abstract]Soc Neurosci Abstr, 20 ,626.9

Caton IB, McKinnon D, Wang H-S, Goodness TP, Davis FE, Alberts KM, Davis BM (1995. ) Overexpression of NGF in skin of transgenic mice increases trkA and p75 expression and size and number of sympathetic neurons .[Abstract]Soc Neurosci Abstr, 21 ,606.6

Wang H-S, Dixon JE, McKinnon D (1995. ) Muscarinic modulation of inward rectifier current in rat sympathetic neurons .[Abstract]Soc Neurosci Abstr, 21 ,524.13

Dixon JE, Shi W, Wang H-S, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D (1996. ) Cloning and characterization of the Kv4.3 channel: a candidate for the transient outward current in dog and human heart .[Abstract]Circulation, 95 ,0029

Wang H-S, Dixon JE, McKinnon D (1996. ) Muscarinic modulation of inward rectifier current .[Abstract]Biophys J, 70 ,Tu-PM-A2

Wang H-S, Dixon JE, McKinnon D (1997. ) Unexpected and differential effects of Cl- channel blockers on the Kv4.3 and Kv4.2 K+ channels - Implications for the study of the Ito2 current .[Abstract]Circulation, 96 ,2375

Yu H, Rosen MR, Danilo P, Steinberg S, Wymore RS, Wang H-S, McKinnon D, Cohen IS (1997. ) Angiotensin II alters Ito properties in cardiac myocytes .[Abstract]Circulation, 96 ,1641

Wang H-S, Shi W, Wymore RS, Pan Z, Cohen IS, Dixon JE, McKinnon D (1997. ) Electrophysiological analysis of two ERG-related channels, ERG2 and ERG3 .[Abstract]Soc Neurosci Abstr, 23 ,476.2

Shi W, Wymore RS, Pan Z, Wang H-S, Cohen IS, McKinnon D, Dixon JE (1997. ) Identification of two nervous system specific members of the ERG potassium channel gene family .[Abstract]Soc Neurosci Abstr, 23 ,126.5

Yu H, Wang H-S, Wymore R, et al (1998. ) Effects of chronic exposure to angiotensin on Ito and Kv4.3 .[Abstract]Biophysical J, 74 (2 ) ,A158

Wang H-S, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1998. ) The KQT2 and KQT3 potassium channel subunits: Molecular correlates of the M-channel .[Abstract]Soc Neurosci Abstr, 24 ,

Wang H-S, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1999. ) The KQT2 and KQT3 potassium channel subunits: Molecular correlates of the M-channel .[Abstract]Biophysical J, 76 ,A330

Wang H-S, Brown BS, McKinnon D, Cohen IS (2000. ) Molecular basis for differential sensitivity of KCNQ1 and IKs-channels to the cognitive enhancer XE991 .[Abstract]Biophysical J, 78 (1 ) ,1200 pos

B, Lypen S, Pan ZM, Wang H-S, Cohen IS, Dixon JE, McKinnon D (2001. ) Contribution of the KChIP2 accessory subunit to native Ito K+ channels in canine heart .[Abstract]Biophysical J, 80 (1 ) ,638A

Wang H-S & Cohen IS (2003. ) Heterogeneity in calcium channel properties in canine ventricular myocytes .[Abstract]Biophysic J, 84 ,426a

Pan Z, Wang H-S, Cohen IS (2004. ) Possible mechanism underlying transmural electrical heterogeneity in canine ventricle .[Abstract]Biophysic J, 86 ,298a

Wang H-S (2004. ) Ionic and molecular basis of transmural electrical heterogeneity .[Abstract]American Heart Association Symposium, New Orleans, LA,

Yuan QY, Altschafl B, Dong M, Fan GC, Jones LR, Wang H-S, Valdivia HH, Chu GX, Kranias EG (2005. ) Junctin deficiency is associated with arrhythmias in Junctin knockout mice .[Abstract]Circulation, 112 ,U268-U268

Sun X & Wang H-S (2005. ) Role of Ito in shaping ventricular action potential – A dynamic clamp study .[Abstract]Biophysic J, 88 ,2222-pos

Dong M, Sun X, Wang H-S (2005. ) Role of the transient outward current in regulating ventricular action potential and contractility: a dynamic clamp study .[Abstract]Circ Res, 97 ,e13

Dong M, Sun X, Printz AA, Wang H-S (2006. ) Effect of simulated Ito on guinea pig and canine ventricular action potential morphology .[Abstract]Biophysic J, 90 ,1980-pos

Dong M & Wang H-S (2006. ) Possible ionic mechanism of contractile dysfunction in Brugada syndrome .[Abstract]Circulation, 114 (18 ) ,1699

Peer Reviewed Publications

Wang H-S & McKinnon D (1995. ) Potassium currents in rat prevertebral and paravertebral sympathetic neurons: control of firing properties .J Physiol, , 485 ,319-335

Dixon JE, Shi W, Wang H-S, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D (1996. ) Role of the Kv4.3 K+ channel in ventricular muscle: a molecular correlate for the transient outward current .Circ Res, , 79 ,659-668

Davis BM, Wang H-S, Albers KM, Carlson SL, Goodness TP, McKinnon D (1996. ) Effects of NGF overexpression on anatomical and physiological properties of sympathetic postganglionic neurons .Brain Res, , 724 ,47-54

Wang H-S & McKinnon D (1996. ) Modulation of inwardly rectifying currents in rat sympathetic neurons by muscarinic receptors .J Physiol, , 492 ,467-478

Wang H-S (1996. ) Analysis of Potassium Channel Function .Doctoral dissertation, SUNY at Stony Brook, Department of Neurobiology and Behavior, ,

Shi W, Wymore RS, Wang H-S, Pan Z, Cohen IS, McKinnon D, Dixon JE (1997. ) Identification of two nervous system specific members of the erg potassium channel gene family .J Neurosci, , 17 ,9423-9432

Wang H-S, Dixon JE, McKinnon D (1997. ) Unexpected and differential effects of Cl- channel blockers on the Kv4.3 and Kv4.2 K+ channels: implications for the study of the Ito2 current .Circ Res, , 81 ,711-718

Shi W, Wang H-S, Pan Z, Wymore RS, Cohen IS, McKinnon D, Dixon JE (1998. ) Cloning of a mammalian Elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia .J Physiol, , 511 ,675-682

Wang H-S, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1998. ) The KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel .Science, , 282 ,1890-1893

Yu H, Gao J, Wang H-S, Wymore R, Steinberg S, Rosen MR, Cohen IS (2000. ) Effects of the renin-angiotensin system on the current Ito in epicardial and endocardial ventricular myocytes from the canine heart .Circ Res, , 86 ,1026-1068

Wang H-S*, Brown BS, McKinnon D, Cohen IS (2000. ) Molecular basis for differential sensitivity of KCNQ and IKs channels to the cognitive enhancer XE991 .Mol Pharmacol, , 57 ,1218-1223

Yu H, Wu J, Potapova I, Wymore RT, Holmes B, Zuckerman J, Pan Z, Wang H-S, Shi W, Robinson RB, El-Maghrabi MR, Benjamin W, Dixon J, McKinnon D, Cohen IS, Wymore R (2001. ) MinK-related peptide 1: A  subunit for the HCN ion channel subunit family enhances expression and speeds activation .Circ Res, , 88 ,e84-e87

Rosati B, Pan Z, Lypen S, Wang H-S, Cohen I, Dixon JE, McKinnon D (2001. ) Regulation of KChIP2 potassium channel  subunit gene expression underlies the gradient of transient outward current in canine and human ventricle .J Physiol, , 533 ,119-125

Wang H-S* & Cohen IS (2003. ) Calcium channel heterogeneity in canine left ventricular myocytes .J Physiol, , 547 ,825-833

Sun X & Wang H-S (2005. ) Role of the transient outward current (Ito) in shaping canine ventricular action potential – a dynamic clamp study .J Physiol, , 564 ,411-419

Zsarnovszky A, Le HH, Wang H-S, Belcher SM (2005. ) Ontogeny of rapid estrogen-mediated ERK1/2 signaling in the rat cerebellar cortex in vivo: potent non-genomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A .Endocrinology, , 146 ,5388-5396

Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, Wang H-S, Schultz JJ, Molkentin JD, Liggett SB, Dorn GW 2nd, Kranias EG (2006. ) Presence of Lys27 Instead of Asn27 in Human Phospholamban Promotes Sarcoplasmic Reticulum Ca2_-ATPase Superinhibition and Cardiac Remodeling .Circulation, , 113 ,995-1004

Dong M, Sun X, Prinz AA & Wang H-S (2006. ) Effect of simulated Ito on guinea pig and canine ventricular action potential morphology .Am J Physiol Heart Circ Physiol, , 291 ,H631-H637

Yuan QY, Fan GC, Dong M, Altschafl B, Diwan A, Ren XP, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW, Wang H-S, Valdivia HH, Chu GX & Kranias EG (2007. ) Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity .Circulation, , 115 ,300-309

Rosati B, Dong M, Cheng L, Liou S-R, Yan Q, Park JY, Shiang E, Sanguinetti M, Wang H-S & McKinnon D (2008. ) Evolution of ventricular myocyte electrophysiology .Physiological Genomics, ,

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack (2012. ) Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.Journal of molecular and cellular cardiology, , 53 (1 ) ,134-44 More Information

Belcher, Scott M; Chen, Yamei; Yan, Sujuan; Wang, Hong-Sheng (2012. ) Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17?-estradiol and the environmental endocrine disruptor bisphenol A.Endocrinology, , 153 (2 ) ,712-20 More Information

Yan, Sujuan; Chen, Yamei; Dong, Min; Song, Weizhong; Belcher, Scott M; Wang, Hong-Sheng (2011. ) Bisphenol A and 17?-estradiol promote arrhythmia in the female heart via alteration of calcium handling.PloS one, , 6 (9 ) ,e25455 More Information

Qian, Jiang; Vafiadaki, Elizabeth; Florea, Stela M; Singh, Vivek P; Song, Weizhong; Lam, Chi Kung; Wang, Yigang; Yuan, Qunying; Pritchard, Tracy J; Cai, Wenfeng; Haghighi, Kobra; Rodriguez, Patricia; Wang, Hong-Sheng; Sanoudou, Despina; Fan, Guo-Chang; Kranias, Evangelia G (2011. ) Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.Circulation research, , 108 (12 ) ,1429-38 More Information

Wang, Hong-Sheng; Arvanitis, Demetrios A; Dong, Min; Niklewski, Paul J; Zhao, Wen; Lam, Chi Keung; Kranias, Evangelia G; Sanoudou, Despina (2011. ) SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts.Physiological genomics, , 43 (7 ) ,357-64 More Information

Dong, Min; Niklewski, Paul J; Wang, Hong-Sheng (2011. ) Ionic mechanisms of cellular electrical and mechanical abnormalities in Brugada syndrome.American journal of physiology. Heart and circulatory physiology, , 300 (1 ) ,H279-87 More Information

Dong, Min; Yan, Sujuan; Chen, Yamei; Niklewski, Paul J; Sun, Xiaoyin; Chenault, Kathryn; Wang, Hong-Sheng (2010. ) Role of the transient outward current in regulating mechanical properties of canine ventricular myocytes.Journal of cardiovascular electrophysiology, , 21 (6 ) ,697-703 More Information

Yuan, Qunying; Han, Peidong; Dong, Min; Ren, Xiaoping; Zhou, Xiaoyang; Chen, Shan; Jones, W Keith; Chu, Guoxiang; Wang, Hong-Sheng; Kranias, Evangelia G (2009. ) Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice.American journal of physiology. Heart and circulatory physiology, , 296 (5 ) ,H1484-90 More Information

Liang, Qian; Gao, Xiaoqian; Chen, Yamei; Hong, Kui; Wang, Hong-Sheng (2014. ) Cellular Mechanism of the Nonmonotonic Dose Response of Bisphenol A in Rat Cardiac Myocytes.Environmental health perspectives, , More Information

Gao, Xiaoqian; Liang, Qian; Chen, Yamei; Wang, Hong-Sheng (2013. ) Molecular mechanisms underlying the rapid arrhythmogenic action of bisphenol A in female rat hearts.Endocrinology, , 154 (12 ) ,4607-17 More Information

Singh, Vivek P; Rubinstein, Jack; Arvanitis, Demetrios A; Ren, Xiaoping; Gao, Xiaoqian; Haghighi, Kobra; Gilbert, Mark; Iyer, Venkat R; Kim, Do Han; Cho, Chunghee; Jones, Keith; Lorenz, John N; Armstrong, Clara F; Wang, Hong-Sheng; Gyorke, Sandor; Kranias, Evangelia G (2013. ) Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.Journal of the American Heart Association, , 2 (5 ) ,e000460 More Information

Yuan, Qunying; Fan, Guo-Chang; Dong, Min; Altschafl, Beth; Diwan, Abhinav; Ren, Xiaoping; Hahn, Harvey H; Zhao, Wen; Waggoner, Jason R; Jones, Larry R; Jones, W Keith; Bers, Donald M; Dorn, Gerald W; Wang, Hong-Sheng; Valdivia, Héctor H; Chu, Guoxiang; Kranias, Evangelia G (2007. ) Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity.Circulation, , 115 (3 ) ,300-9 More Information

Dong, Min; Sun, Xiaoyin; Prinz, Astrid A; Wang, Hong-Sheng (2006. ) Effect of simulated I(to) on guinea pig and canine ventricular action potential morphology.American journal of physiology. Heart and circulatory physiology, , 291 (2 ) ,H631-7 More Information

Zhao, Wen; Yuan, Qunying; Qian, Jiang; Waggoner, Jason R; Pathak, Anand; Chu, Guoxiang; Mitton, Bryan; Sun, Xiaoyin; Jin, Jay; Braz, Julian C; Hahn, Harvey S; Marreez, Yehia; Syed, Faisal; Pollesello, Piero; Annila, Arto; Wang, Hong-Sheng; Schultz, Jo El J; Molkentin, Jeffery D; Liggett, Stephen B; Dorn, Gerald W; Kranias, Evangelia G (2006. ) The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.Circulation, , 113 (7 ) ,995-1004 More Information

Zsarnovszky, Attila; Le, Hoa H; Wang, Hong-Sheng; Belcher, Scott M (2005. ) Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A.Endocrinology, , 146 (12 ) ,5388-96 More Information

Sun, Xiaoyin; Wang, Hong-Sheng (2005. ) Role of the transient outward current (Ito) in shaping canine ventricular action potential--a dynamic clamp study.The Journal of physiology, , 564 (Pt 2 ) ,411-9 More Information

Wang, Hong-Sheng; Cohen, Ira S (2003. ) Calcium channel heterogeneity in canine left ventricular myocytes.The Journal of physiology, , 547 (Pt 3 ) ,825-33 More Information

Gao, Xiaoqian; Ma, Jianyong; Chen, Yamei; Wang, Hong-Sheng (2015. ) Rapid Responses and Mechanism of Action for Low-Dose Bisphenol S on ex Vivo Rat Hearts and Isolated Myocytes: Evidence of Female-Specific Proarrhythmic Effects.Environmental health perspectives, , More Information

Wang, Hong-Sheng; Chen, Yamei; Vairamani, Kanimozhi; Shull, Gary E (2014. ) Critical role of bicarbonate and bicarbonate transporters in cardiac function.World journal of biological chemistry, , 5 (3 ) ,334-45 More Information

Gao, Xiaoqian; Wang, Hong-Sheng (2014. ) Impact of bisphenol a on the cardiovascular system - epidemiological and experimental evidence and molecular mechanisms.International journal of environmental research and public health, , 11 (8 ) ,8399-413 More Information

Vairamani, Kanimozhi; Wang, Hong-Sheng; Medvedovic, Mario; Lorenz, John N; Shull, Gary E (2017. ) RNA SEQ Analysis Indicates that the AE3 Cl(-)/HCO3(-) Exchanger Contributes to Active Transport-Mediated CO2 Disposal in Heart.Scientific reports, , 7 (1 ) ,7264 More Information

Ma, Jianyong; Hong, Kui; Wang, Hong-Sheng (2017. ) Progesterone Protects Against Bisphenol A-Induced Arrhythmias in Female Rat Cardiac Myocytes via Rapid Signaling.Endocrinology, , 158 (4 ) ,778-790 More Information

Koneva, L A; Vyas, A K; McEachin, R C; Puttabyatappa, M; Wang, H-S; Sartor, M A; Padmanabhan, V (2017. ) Developmental programming: Interaction between prenatal BPA and postnatal overfeeding on cardiac tissue gene expression in female sheep.Environmental and molecular mutagenesis, , 58 (1 ) ,4-18 More Information

Haghighi, Kobra; Pritchard, Tracy J; Liu, Guan-Sheng; Singh, Vivek P; Bidwell, Philip; Lam, Chi Keung; Vafiadaki, Elizabeth; Das, Parthib; Ma, Jianyong; Kunduri, Swati; Sanoudou, Despina; Florea, Stela; Vanderbilt, Erica; Wang, Hong-Shang; Rubinstein, Jack; Hajjar, Roger J; Kranias, Evangelia G (2015. ) Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.Journal of molecular and cellular cardiology, , 89 (Pt B ) ,349-59 More Information

Xiong, Qinmei; Liu, Xiao; Shen, Yang; Yu, Peng; Chen, Sisi; Hu, Jinzhu; Yu, Jianhua; Li, Juxiang; Wang, Hong-Sheng; Cheng, Xiaoshu; Hong, Kui (2015. ) Elevated serum Bisphenol A level in patients with dilated cardiomyopathy.International journal of environmental research and public health, , 12 (5 ) ,5329-37 More Information

Vought, Victoria; Wang, Hong-Sheng (2018. ) Impact of common environmental chemicals bisphenol A and bisphenol S on the physiology of Lumbriculus variegatus.Environmental toxicology and pharmacology, , 60 ,225-229 More Information

Invited Publications

Wang H-S (2002. ) The M-channel: from function to genes .Fudan Lect Neurobiol, 18 ,125-140

Invited Presentations

(1999. ) “The M-channel: from function to genes” .Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.

(1999. ) “KCNQ2 and KCNQ3: molecular identity of the neuronal M-channel” .Life Sciences Institute and Department of Neurobiology, University of Science and Technology of China, Hefei, China.

(2000. ) “The M-channel: from function to genes” .Symposium on Neuroscience for Chinese Scholars, Hefei, China.

(2001. ) “KCNQ2 and KCNQ3 genes, the M-channel, and epilepsy” .Department of Physiology, New York College of Osteopathic Medicine, New York Institute of Technology, Westbury, New York.

(2001. ) “Understanding the electrical properties of the ventricle and ventricular arrhythmias” .American Heart Association New York regional board meeting, New York.

(2001. ) “Potassium channel function in sympathetic neurons and the heart” .Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

(2003. ) “Transmural electrical heterogeneity across the ventricular wall: implication for ventricular contractile properties” .Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

(2005. ) “Role of the transient outward current (Ito) in ventricular myocytes” .Institute of Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, New York.

(2005. ) “The transient outward current and electrical and mechanical properties of cardiac myocytes” .Institute of Molecular Medicine, Beijing University, Beijing, China.

(2006. ) “Ionic basis of the Brugada syndrome” .Department of Neuroscience and Biophysics, University of Science and Technology of China, Hefei, China.

(2006. ) “Role of the transient outward current in ventricular myocytes” .College of Life Sciences, Fudan University, Shanghai, China.

Lecture

(2003. ) “Ion channels and neuronal development” .University of Cincinnati, College of Medicine.

(2003. ) “Ion channels and neuronal plasticity” .University of Cincinnati, College of Medicine.

(2004. ) “Cardiac electrophysiology” .University of Cincinnati, College of Medicine.

(2006. ) “Ion channels”, “The excitable membrane”, “Ion channels as drug targets” .University of Cincinnati, College of Medicine.

(2005. ) “Effective data presentation” .University of Cincinnati, College of Medicine.

(2005. ) "Neuropharmacology: Cognition and Memory Drugs” .University of Cincinnati, College of Medicine.

(2004. ) “Ion channels as drug targets” .University of Cincinnati, College of Medicine.

(2005. ) “Drugs regulating hemostasis and erythropoiesis” .University of Cincinnati, College of Medicine.

(2006. ) “Drugs regulating hemostasis and erythropoiesis”, “Pharmacokinetics I”, “Pharmacokinetics II” .University of Cincinnati, College of Medicine.

(2007. ) “Drugs regulating hemostasis and erythropoiesis” “Pharmacokinetics I” “Pharmacokinetics II” “Antiarrhythmic Drugs” .University of Cincinnati, College of Medicine.

(2004. ) University of Cincinnati, College of Medicine.

1998 -2000 American Heart Association Postdoctoral Fellowship

1998 Grass Fellowship in Neurobiology at the Marine Biological Laboratory

1994 -To Present: Society for Neuroscience

1996 -To Present: Biophysical Society

2001 -To Present: American Association for the Advancement of Science

2004 -To Present: American Heart Association, Council on Basic Cardiovascular Sciences

2007 -To Present: American Society for Pharmacology and Experimental Therapeutics

2007 -To Present: Member American Heart Association, Region I, Cell Transport, Physiology & Metabolism Study Section,

Serve as ad hoc reviewer for the following journals (4 – 5 per year) Journal of Physiology British Journal of Pharmacology American Journal of Physiology Biochimica et Biophysica Acta Toxicology Letters Cardiovascular Pharmacology Cellular Physiology and Biochemistry.

2002 -2004: University Research Council (URC), member Duties – review and critique dozens of intramural Faculty Research Fellowship and Graduate Student Research Fellowship applications three funding circles per year, for a total of over a hundred applications each year University of Cincinnati, Cincinnati, OH

2003: URC Life Sciences Subcommittee, Chair Duties – in addition to reviewing and critiquing URC fellowship applications, additional duties of the Subcommittee Chair involved making review assignment, organizing the reviewing process and meetings, writing Summary Statements for each application, and making funding recommendations to the Associate Vice President for Research University of Cincinnati, Cincinnati, OH

2002 -To Present: Office of Sponsored Programs Advisory Committee, member Duties – provide recommendations of operation of the office and feedbacks on grant application review and approval procedures University of Cincinnati, Cincinnati, OH

2007 -To Present: Appointment, Reappointment, Promotion and Tenure (ARPT) Committee, alternate member Duties – evaluate and review all PCB requests for ARPT based on Departmental requirements UC Department of Pharmacology and Cell Biophysics, Cincinnati, OH

2002 -To Present: PCB Space Committee, member Duties – review PCB departmental space allocation and re-assignment, and make recommendations of most efficient use of departmental space to the Chair UC Department of Pharmacology and Cell Biophysics, Cincinnati, OH

2002 -To Present: PCB Mission Continuity Committee, member Duties – prepare action plans for the continuous operation of the department, such as identifying and backing up of vital records used for daily processes, and recovering critical departmental functions in case of a disastrous incident UC Department of Pharmacology and Cell Biophysics, Cincinnati, OH

2003 -2004: Shirley Bryant Memorial Lecture/Dean’s Lecture Committee, Chair Duties – responsible for speaker selection and invitation, nomination of the speaker for the COM Dean’s Lectureship, and organization of the lectures. After one year of preparation, the lecture was held on April 8, 2004. Dr. Frances Ashcroft, a highly distinguished ion channel researcher, delivered two lectures titled “ATP-Sensitive K Channels and Insulin Secretion in Health and Disease” and “Structure-Function Studies of KATP Channels”. UC Department of Pharmacology and Cell Biophysics, Cincinnati, OH

2004 -To Present: PCB Graduate Education Committee (GEC), member Duties – the GEC meets as required and makes policy decisions regarding the oversight of all aspects of the Pharmacology Graduate Program. Members evaluate applications, assist in recruitment, make admission decisions and evaluate the progress of current students. I was responsible for evaluating foreign applications, conducted extensive telephone interviews, and made admission recommendations to the GEC. UC Department of Pharmacology and Cell Biophysics, Cincinnati, OH

2007 -To Present: PCB GEC Recruitment Subcommittee, member Duties – development of recruitment material, recruitment of quality applicants to the PCB graduate program UC Department of Pharmacology and Cell Biophysics, Cincinnati, OH

2003: Faculty Judge University of Cincinnati College of Medicine Graduate Student Research Forum University of Cincinnati, College of Medicine, Cincinnati, OH

2004 -To Present: Faculty Supervisor Chinese Student and Scholar Association (CSSA) of University of Cincinnati University of Cincinnati, College of Medicine, Cincinnati, OH

2008: Interviewer University of Cincinnati College of Medicine Biomedical Sciences Flex Option Graduate Program University of Cincinnati, College of Medicine, Cincinnati, OH

Academic - Medical Sciences Building
Room 5151
Cincinnati  Ohio, 45267-0575
Phone: 513-558-2379
wanghs@ucmail.uc.edu