Sing Sing  Way

Sing Sing Way

Professor-Affiliate

Childrens Hospital Bldg R

COM Pediatrics Infectious Diseases - 0054

CCHMC S Building
240 Albert Sabin Way
Cincinnati, Ohio 45229

Research Support

Grant: #BWF 1011031 Investigators:Ball, William; Way, Sing_Sing 10-01-2012 -09-30-2017 Burroughs Wellcome Fund Maternal Regulatory T cells Control the Immune Pathogenesis of Prenatal Infection Role:Collaborator $500,000.00 Active Level:Private Non-Profit

Publications

Peer Reviewed Publications

Xin, Lijun; Jiang, Tony T; Kinder, Jeremy M; Ertelt, James M; Way, Sing Sing (2015. )Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice.Aging cell, ,

Kinder, Jeremy M; Jiang, Tony T; Ertelt, James M; Xin, Lijun; Strong, Beverly S; Shaaban, Aimen F; Way, Sing Sing (2015. )Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells.Cell, ,162 (3 ),505-15

Chaturvedi, Vandana; Ertelt, James M; Jiang, Tony T; Kinder, Jeremy M; Xin, Lijun; Owens, Kathryn J; Jones, Helen N; Way, Sing Sing (2015. )CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage.The Journal of clinical investigation, ,125 (4 ),1713-25

PrabhuDas, Mercy; Bonney, Elizabeth; Caron, Kathleen; Dey, Sudhansu; Erlebacher, Adrian; Fazleabas, Asgerally; Fisher, Susan; Golos, Thaddeus; Matzuk, Martin; McCune, Joseph M; Mor, Gil; Schulz, Laura; Soares, Michael; Spencer, Thomas; Strominger, Jack; Way, Sing Sing; Yoshinaga, Koji (2015. )Immune mechanisms at the maternal-fetal interface: perspectives and challenges.Nature immunology, ,16 (4 ),328-34

Nanton, Minelva R; Lee, Seung-Joo; Atif, Shaikh M; Nuccio, Sean-Paul; Taylor, Justin J; Bäumler, Andreas J; Way, Sing Sing; McSorley, Stephen J (2015. )Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development.European journal of immunology, ,45 (2 ),428-41

Drummond, Rebecca A; Wallace, Carol; Reid, Delyth M; Way, Sing Sing; Kaplan, Daniel H; Brown, Gordon D (2014. )Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis.Journal of immunology (Baltimore, Md. : 1950), ,193 (11 ),5381-5

Clark, Dayna R; Chaturvedi, Vandana; Kinder, Jeremy M; Jiang, Tony T; Xin, Lijun; Ertelt, James M; Way, Sing Sing (2014. )Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy.Cellular & molecular immunology, ,11 (6 ),595-605

Xin, Lijun; Jiang, Tony T; Chaturvedi, Vandana; Kinder, Jeremy M; Ertelt, James M; Rowe, Jared H; Steinbrecher, Kris A; Way, Sing Sing (2014. )Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2.Proceedings of the National Academy of Sciences of the United States of America, ,111 (29 ),10672-7

Jiang, Tony T; Chaturvedi, Vandana; Ertelt, James M; Kinder, Jeremy M; Clark, Dayna R; Valent, Amy M; Xin, Lijun; Way, Sing Sing (2014. )Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.Journal of immunology (Baltimore, Md. : 1950), ,192 (11 ),4949-56

Xin, Lijun; Ertelt, James M; Rowe, Jared H; Jiang, Tony T; Kinder, Jeremy M; Chaturvedi, Vandana; Elahi, Shokrollah; Way, Sing Sing (2014. )Cutting edge: committed Th1 CD4+ T cell differentiation blocks pregnancy-induced Foxp3 expression with antigen-specific fetal loss.Journal of immunology (Baltimore, Md. : 1950), ,192 (7 ),2970-4

Kinder, Jeremy M; Jiang, Tony T; Clark, Dayna R; Chaturvedi, Vandana; Xin, Lijun; Ertelt, James M; Way, Sing Sing Pregnancy-induced maternal regulatory T cells, bona fide memory or maintenance by antigenic reminder from fetal cell microchimerism?.Chimerism, ,5 (1 ),16-9

Elahi, Shokrollah; Ertelt, James M; Kinder, Jeremy M; Jiang, Tony T; Zhang, Xuzhe; Xin, Lijun; Chaturvedi, Vandana; Strong, Beverly S; Qualls, Joseph E; Steinbrecher, Kris A; Kalfa, Theodosia A; Shaaban, Aimen F; Way, Sing Sing (2013. )Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection.Nature, ,504 (7478 ),158-62

Rowe, Jared H; Ertelt, James M; Xin, Lijun; Way, Sing Sing (2013. )Regulatory T cells and the immune pathogenesis of prenatal infection.Reproduction (Cambridge, England), ,146 (6 ),R191-203

Ertelt, James M; Buyukbasaran, Esra Z; Jiang, Tony T; Rowe, Jared H; Xin, Lijun; Way, Sing Sing (2013. )B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells.Journal of leukocyte biology, ,94 (2 ),367-76

Shafiani, Shahin; Dinh, Crystal; Ertelt, James M; Moguche, Albanus O; Siddiqui, Imran; Smigiel, Kate S; Sharma, Pawan; Campbell, Daniel J; Way, Sing Sing; Urdahl, Kevin B (2013. )Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.Immunity, ,38 (6 ),1261-70

Tubo, Noah J; Pagán, Antonio J; Taylor, Justin J; Nelson, Ryan W; Linehan, Jonathan L; Ertelt, James M; Huseby, Eric S; Way, Sing Sing; Jenkins, Marc K (2013. )Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.Cell, ,153 (4 ),785-96

Burnaevskiy, Nikolay; Fox, Thomas G; Plymire, Daniel A; Ertelt, James M; Weigele, Bethany A; Selyunin, Andrey S; Way, Sing Sing; Patrie, Steven M; Alto, Neal M (2013. )Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.Nature, ,496 (7443 ),106-9

Nanton, Minelva R; Way, Sing Sing; Shlomchik, Mark J; McSorley, Stephen J (2012. )Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.Journal of immunology (Baltimore, Md. : 1950), ,189 (12 ),5503-7

Rowe, Jared H; Ertelt, James M; Xin, Lijun; Way, Sing Sing (2012. )Pregnancy imprints regulatory memory that sustains anergy to fetal antigen.Nature, ,490 (7418 ),102-6

Rowe, Jared H; Ertelt, James M; Way, Sing Sing (2012. )Innate IFN-? is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection.Journal of immunology (Baltimore, Md. : 1950), ,189 (2 ),876-84

Rowe, Jared H; Ertelt, James M; Way, Sing Sing (2012. )Foxp3(+) regulatory T cells, immune stimulation and host defence against infection.Immunology, ,136 (1 ),1-10

Kanistanon, Duangjit; Powell, Daniel A; Hajjar, Adeline M; Pelletier, Mark R; Cohen, Ilana E; Way, Sing Sing; Skerrett, Shawn J; Wang, Xiaoyuan; Raetz, Christian R H; Ernst, Robert K (2012. )Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.Infection and immunity, ,80 (3 ),943-51

Rowe, Jared H; Ertelt, James M; Xin, Lijun; Way, Sing Sing (2012. )Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance.PLoS pathogens, ,8 (8 ),e1002873

Ertelt, James M; Johanns, Tanner M; Mysz, Margaret A; Nanton, Minelva R; Rowe, Jared H; Aguilera, Marijo N; Way, Sing Sing (2011. )Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection.Immunology, ,134 (4 ),487-97

Ertelt, James M; Rowe, Jared H; Mysz, Margaret A; Singh, Charanjeet; Roychowdhury, Monika; Aguilera, Marijo N; Way, Sing Sing (2011. )Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells.Journal of immunology (Baltimore, Md. : 1950), ,187 (5 ),2569-77

Rudd, Brian D; Venturi, Vanessa; Li, Gang; Samadder, Partha; Ertelt, James M; Way, Sing Sing; Davenport, Miles P; Nikolich-Žugich, Janko (2011. )Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions.Proceedings of the National Academy of Sciences of the United States of America, ,108 (33 ),13694-9

Rowe, Jared H; Ertelt, James M; Aguilera, Marijo N; Farrar, Michael A; Way, Sing Sing (2011. )Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens.Cell host & microbe, ,10 (1 ),54-64

Johanns, Tanner M; Law, Calvin Y; Kalekar, Lokeshchandra A; O'Donnell, Hope; Ertelt, James M; Rowe, Jared H; Way, Sing Sing (2011. )Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.Microbes and infection / Institut Pasteur, ,13 (4 ),322-30

Han, Jin-Young; Hanson, David C; Way, Sing Sing (2011. )Herpes zoster and meningitis due to reactivation of varicella vaccine virus in an immunocompetent child.The Pediatric infectious disease journal, ,30 (3 ),266-8

Ertelt, James M; Johanns, Tanner M; Rowe, Jared H; Way, Sing Sing (2010. )Interleukin (IL)-21-independent pathogen-specific CD8+ T-cell expansion, and IL-21-dependent suppression of CD4+ T-cell IL-17 production.Immunology, ,131 (2 ),183-91

Curtis, Meredith M; Rowell, Emily; Shafiani, Shahin; Negash, Amina; Urdahl, Kevin B; Wilson, Christopher B; Way, Sing Sing (2010. )Fidelity of pathogen-specific CD4+ T cells to the Th1 lineage is controlled by exogenous cytokines, interferon-gamma expression, and pathogen lifestyle.Cell host & microbe, ,8 (2 ),163-73

Johanns, Tanner M; Ertelt, James M; Rowe, Jared H; Way, Sing Sing (2010. )Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection.PLoS pathogens, ,6 (8 ),e1001043

Winstead, Colleen J; Reilly, Cavan S; Moon, James J; Jenkins, Marc K; Hamilton, Sara E; Jameson, Stephen C; Way, Sing Sing; Khoruts, Alexander (2010. )CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia.Journal of immunology (Baltimore, Md. : 1950), ,184 (9 ),4749-60

Rudd, Brian D; Venturi, Vanessa; Smithey, Megan J; Way, Sing Sing; Davenport, Miles P; Nikolich-Zugich, Janko (2010. )Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection.Journal of immunology (Baltimore, Md. : 1950), ,184 (6 ),2958-65

Johanns, Tanner M; Ertelt, James M; Lai, Joseph C; Rowe, Jared H; Avant, Ross A; Way, Sing Sing (2010. )Naturally occurring altered peptide ligands control Salmonella-specific CD4+ T cell proliferation, IFN-gamma production, and protective potency.Journal of immunology (Baltimore, Md. : 1950), ,184 (2 ),869-76

Rowe, Jared H; Johanns, Tanner M; Ertelt, James M; Lai, Joseph C; Way, Sing Sing (2009. )Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge.Immunology, ,128 (1 Suppl ),e471-8

Curtis, Meredith M; Way, Sing Sing; Wilson, Christopher B (2009. )IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons.Journal of immunology (Baltimore, Md. : 1950), ,183 (1 ),381-7

Ertelt, James M; Rowe, Jared H; Johanns, Tanner M; Lai, Joseph C; McLachlan, James B; Way, Sing Sing (2009. )Selective priming and expansion of antigen-specific Foxp3- CD4+ T cells during Listeria monocytogenes infection.Journal of immunology (Baltimore, Md. : 1950), ,182 (5 ),3032-8

Curtis, Meredith M; Way, Sing Sing (2009. )Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens.Immunology, ,126 (2 ),177-85

Rowe, Jared H; Johanns, Tanner M; Ertelt, James M; Way, Sing Sing (2008. )PDL-1 blockade impedes T cell expansion and protective immunity primed by attenuated Listeria monocytogenes. Journal of immunology (Baltimore, Md. : 1950), ,180 (11 ),7553-7

Orgun, Nural N; Mathis, Meredith A; Wilson, Christopher B; Way, Sing Sing (2008. )Deviation from a strong Th1-dominated to a modest Th17-dominated CD4 T cell response in the absence of IL-12p40 and type I IFNs sustains protective CD8 T cells. Journal of immunology (Baltimore, Md. : 1950), ,180 (6 ),4109-15

Orgun, Nural N; Way, Sing Sing (2008. )A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes.Microbial pathogenesis, ,44 (2 ),159-63

Muller, William J; Orgun, Nural N; Dong, Lichun; Koelle, David M; Huang, Meei-Li; Way, Sing Sing (2008. )Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2.Archives of virology, ,153 (6 ),1165-9

Asplin, Iain R; Carl, David J; Way, Sing Sing; Jones, Amanda L (2008. )Role of Toll-like receptor 2 in innate resistance to Group B Streptococcus.Microbial pathogenesis, ,44 (1 ),43-51

Orr, Mark T; Orgun, Nural N; Wilson, Christopher B; Way, Sing Sing (2007. )Cutting edge: recombinant Listeria monocytogenes expressing a single immune-dominant peptide confers protective immunity to herpes simplex virus-1 infection. Journal of immunology (Baltimore, Md. : 1950), ,178 (8 ),4731-5

Way, Sing Sing; Havenar-Daughton, Colin; Kolumam, Ganesh A; Orgun, Nural N; Murali-Krishna, Kaja (2007. )IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection. Journal of immunology (Baltimore, Md. : 1950), ,178 (7 ),4498-505

Kollmann, Tobias R; Reikie, Brian; Blimkie, Darren; Way, Sing Sing; Hajjar, Adeline M; Arispe, Kiea; Shaulov, Angela; Wilson, Christopher B (2007. )Induction of protective immunity to Listeria monocytogenes in neonates. Journal of immunology (Baltimore, Md. : 1950), ,178 (6 ),3695-701

Way, Sing Sing; Wilson, Christopher B (2005. )The Mycobacterium tuberculosis ESAT-6 homologue in Listeria monocytogenes is dispensable for growth in vitro and in vivo.Infection and immunity, ,73 (9 ),6151-3

Way, Sing Sing; Wilson, Christopher B (2004. )Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet. Journal of immunology (Baltimore, Md. : 1950), ,173 (10 ),5918-22

Darveau, Richard P; Pham, Thu-Thao T; Lemley, Kayde; Reife, Robert A; Bainbridge, Brian W; Coats, Stephen R; Howald, William N; Way, Sing Sing; Hajjar, Adeline M (2004. )Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4.Infection and immunity, ,72 (9 ),5041-51

Kollmann, Tobias R; Way, Sing Sing; Harowicz, Heidi L; Hajjar, Adeline M; Wilson, Christopher B (2004. )Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells.Blood, ,103 (11 ),4240-2

Way, Sing Sing; Thompson, Lucas J; Lopes, Jared E; Hajjar, Adeline M; Kollmann, Tobias R; Freitag, Nancy E; Wilson, Christopher B (2004. )Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cellular microbiology, ,6 (3 ),235-42

Way, Sing Sing; Kollmann, Tobias R; Hajjar, Adeline M; Wilson, Christopher B (2003. )Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88. Journal of immunology (Baltimore, Md. : 1950), ,171 (2 ),533-7

Shetron-Rama, Lynne M; Mueller, Kimberly; Bravo, Juan M; Bouwer, H G Archie; Way, Sing Sing; Freitag, Nancy E (2003. )Isolation of Listeria monocytogenes mutants with high-level in vitro expression of host cytosol-induced gene products. Molecular microbiology, ,48 (6 ),1537-51

Contact Information

Academic - CCHMC S Building
240 Albert Sabin Way
Cincinnati  Ohio, 45229
Phone: 513-636-7603
singsing.way@cchmc.org