Susanne Wells , PhD

Our current research activities focus on the biology of human epithelial tissues, particularly the epidermis and mucosa, which protect the organism from a hostile environment. As such, we seek to understand gene-environment interactions, including their effects on individuals and their impact on public health.

This research comprises three main areas: 1) directed differentiation of induced pluripotent stem cells into organoids for disease phenotype discovery; 2) studies of intrinsic and environmental stressors of the human epidermis including HPV infection, oncogenic stimuli, metabolic deregulation and radiation; and 3) squamous cell carcinoma and breast cancer development and progression.

In addition to the use of established systems, we have developed and published personalized human models. These include primary patient skin and tumor specimens, as well as derivative cell populations, 3-D spheres and engineered tissues. Genomic, transcriptomic, metabolomic and mechanistic exploration of these systems aims to discover disease drivers and biomarkers. Data obtained are then validated in human cohorts, xenografts and/or genetic mouse models. Our long-term goal is to identify cellular and viral determinants of cancer and to explore their targeting for the purpose of new interventions.

While fundamental basic knowledge discovery remains an important component of our program, we have made key transitions into the realm of translation. Research findings are thus routinely advanced by collaborating clinical teams at Cincinnati Children’s Hospital, the University of Cincinnati, and other national and international Institutions.

Peer Reviewed Publications

Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I (2014. ) High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.Journal of virology, , 88 (19 ) ,11315-26 More Information

Adams, Allie K; Wise-Draper, Trisha M; Wells, Susanne I (2014. ) Human papillomavirus induced transformation in cervical and head and neck cancers.Cancers, , 6 (3 ) ,1793-820 More Information

Bahassi, El Mustapha; Li, Ya-Qin; Wise-Draper, Trisha M; Deng, Li; Wang, Jiang; Darnell, Colleen N; Wilson, Keith M; Wells, Susanne I; Stambrook, Peter J; Rixe, Olivier (2013. ) A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer.European journal of cancer (Oxford, England : 1990), , 49 (10 ) ,2345-55 More Information

Romick-Rosendale, Lindsey E; Lui, Vivian W Y; Grandis, Jennifer R; Wells, Susanne I The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.Mutation research, , 743-744 ,78-88 More Information

Privette Vinnedge, Lisa M; Kappes, Ferdinand; Nassar, Nicolas; Wells, Susanne I (2013. ) Stacking the DEK: from chromatin topology to cancer stem cells.Cell cycle (Georgetown, Tex.), , 12 (1 ) ,51-66 More Information

Yablonska, Svitlana; Hoskins, Elizabeth E; Wells, Susanne I; Khan, Saleem A (2013. ) Identification of miRNAs dysregulated in human foreskin keratinocytes (HFKs) expressing the human papillomavirus (HPV) Type 16 E6 and E7 oncoproteins. MicroRNA (Shariqah, United Arab Emirates), , 2 (1 ) ,2-13

Kim, Kui-Jin; Godarova, Alzbeta; Seedle, Kari; Kim, Min-Ho; Ince, Tan A; Wells, Susanne I; Driscoll, James J; Godar, Samuel (2013. ) Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner.PloS one, , 8 (12 ) ,e80590 More Information

Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) Future directions and treatment strategies for head and neck squamous cell carcinomas.Translational research : the journal of laboratory and clinical medicine, , 160 (3 ) ,167-77 More Information

Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) The fanconi anemia pathway limits human papillomavirus replication.Journal of virology, , 86 (15 ) ,8131-8 More Information

Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.PloS one, , 7 (10 ) ,e46985 More Information

Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I (2011. ) Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility.Journal of virology, , 85 (20 ) ,10487-98 More Information

Kavanaugh, Gina M; Wise-Draper, Trisha M; Morreale, Richard J; Morrison, Monique A; Gole, Boris; Schwemberger, Sandy; Tichy, Elisia D; Lu, Lu; Babcock, George F; Wells, James M; Drissi, Rachid; Bissler, John J; Stambrook, Peter J; Andreassen, Paul R; Wiesmüller, Lisa; Wells, Susanne I (2011. ) The human DEK oncogene regulates DNA damage response signaling and repair.Nucleic acids research, , 39 (17 ) ,7465-76 More Information

Myers, Kasiani C; Bleesing, Jack J; Davies, Stella M; Zhang, Xue; Martin, Lisa J; Mueller, Robin; Harris, Richard E; Filipovich, Alexandra H; Kovacic, Melinda B; Wells, Susanne I; Mehta, Parinda A (2011. ) Impaired immune function in children with Fanconi anaemia.British journal of haematology, , 154 (2 ) ,234-40 More Information

Wald, Abigail I; Hoskins, Elizabeth E; Wells, Susanne I; Ferris, Robert L; Khan, Saleem A (2011. ) Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus.Head & neck, , 33 (4 ) ,504-12 More Information

Spence, Jason R; Mayhew, Christopher N; Rankin, Scott A; Kuhar, Matthew F; Vallance, Jefferson E; Tolle, Kathryn; Hoskins, Elizabeth E; Kalinichenko, Vladimir V; Wells, Susanne I; Zorn, Aaron M; Shroyer, Noah F; Wells, James M (2011. ) Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.Nature, , 470 (7332 ) ,105-9 More Information

Meyer, Sara E; Peace, Belinda E; Bahassi, El Mustapha; Kavanaugh, Gina M; Wagh, Purnima K; Robbins, Susan B; Yin, Moying; Wells, Susanne I; Zinser, Glendon M; Stambrook, Peter J; Waltz, Susan E (2010. ) Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.Cancer letters, , 296 (2 ) ,186-93 More Information

Spardy, Nicole; Covella, Kathryn; Cha, Elliot; Hoskins, Elizabeth E; Wells, Susanne I; Duensing, Anette; Duensing, Stefan (2009. ) Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.Cancer research, , 69 (17 ) ,7022-9 More Information

Wise-Draper, Trisha M; Mintz-Cole, Rachael A; Morris, Teresa A; Simpson, David S; Wikenheiser-Brokamp, Kathryn A; Currier, Mark A; Cripe, Timothy P; Grosveld, Gerard C; Wells, Susanne I (2009. ) Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.Cancer research, , 69 (5 ) ,1792-9 More Information

Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I (2009. ) DEK proto-oncogene expression interferes with the normal epithelial differentiation program.The American journal of pathology, , 174 (1 ) ,71-81 More Information

Bourgo, Ryan J; Braden, Wesley A; Wells, Susanne I; Knudsen, Erik S (2009. ) Activation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines.Molecular carcinogenesis, , 48 (1 ) ,45-55 More Information

Spardy, Nicole; Duensing, Anette; Hoskins, Elizabeth E; Wells, Susanne I; Duensing, Stefan (2008. ) HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.Cancer research, , 68 (23 ) ,9954-63 More Information

Wise-Draper, Trisha M; Wells, Susanne I (2008. ) Papillomavirus E6 and E7 proteins and their cellular targets. Frontiers in bioscience : a journal and virtual library, , 13 ,1003-17

Blanchard, Carine; Mingler, Melissa K; Vicario, Maria; Abonia, J Pablo; Wu, Yi Ying; Lu, Thomas X; Collins, Margaret H; Putnam, Philip E; Wells, Susanne I; Rothenberg, Marc E (2007. ) IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids.The Journal of allergy and clinical immunology, , 120 (6 ) ,1292-300 More Information

Jones, Elizabeth E; Wells, Susanne I (2006. ) Cervical cancer and human papillomaviruses: inactivation of retinoblastoma and other tumor suppressor pathways. Current molecular medicine, , 6 (7 ) ,795-808

Wise-Draper, Trisha M; Allen, Hillary V; Jones, Elizabeth E; Habash, Kristen B; Matsuo, Hiroshi; Wells, Susanne I (2006. ) Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions.Molecular and cellular biology, , 26 (20 ) ,7506-19 More Information

Wise-Draper, Trisha M; Allen, Hillary V; Thobe, Megan N; Jones, Elizabeth E; Habash, Kristen B; Münger, Karl; Wells, Susanne I (2005. ) The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.Journal of virology, , 79 (22 ) ,14309-17 More Information

Wells, Susanne I; Aronow, Bruce J; Wise, Trisha M; Williams, Sarah S; Couget, Jennifer A; Howley, Peter M (2003. ) Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.Proceedings of the National Academy of Sciences of the United States of America, , 100 (12 ) ,7093-8 More Information

Erturk, Ece; Ostapchuk, Philomena; Wells, Susanne I; Yang, Jihong; Gregg, Keqin; Nepveu, Alain; Dudley, Jaquelin P; Hearing, Patrick (2003. ) Binding of CCAAT displacement protein CDP to adenovirus packaging sequences. Journal of virology, , 77 (11 ) ,6255-64

Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmueller, Lisa; Hanenberg, Helmut; Andreassen, Paul; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura; Wells, Susanne I (2015. ) Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers.Clinical cancer research : an official journal of the American Association for Cancer Research, , 21 (8 ) ,1962-72 More Information

Matrka, Marie C; Hennigan, Robert F; Kappes, Ferdinand; DeLay, Monica L; Lambert, Paul F; Aronow, Bruce J; Wells, Susanne I (2015. ) DEK over-expression promotes mitotic defects and micronucleus formation.Cell cycle (Georgetown, Tex.), , 14 (24 ) ,3939-53 More Information

Sauter, Sharon L; Wells, Susanne I; Zhang, Xue; Hoskins, Elizabeth E; Davies, Stella M; Myers, Kasiani C; Mueller, Robin; Panicker, Gitika; Unger, Elizabeth R; Sivaprasad, Umasundari; Brown, Darron R; Mehta, Parinda A; Butsch Kovacic, Melinda (2015. ) Oral human papillomavirus is common in individuals with Fanconi anemia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , 24 (5 ) ,864-72 More Information

Matrka, Marie C; Cimperman, Katherine A; Haas, Sarah R; Guasch, Geraldine; Ehrman, Lisa A; Waclaw, Ronald R; Komurov, Kakajan; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2018. ) Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.PLoS genetics, , 14 (3 ) ,e1007227 More Information

Zhao, Xueheng; Brusadelli, Marion G; Sauter, Sharon L; Butsch Kovacic, Melinda; Zhang, Wujuan; Romick-Rosendale, Lindsey E; Lambert, Paul F; Setchell, Kenneth D; Wells, Susanne I (2018. ) Lipidomic profiling links the Fanconi anemia pathway to glycosphingolipid metabolism in head and neck cancer cells.Clinical cancer research : an official journal of the American Association for Cancer Research, , More Information

Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M (2018. ) Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.Experimental hematology, , 59 ,40-50.e3 More Information

Khoury, Ruby; Sauter, Sharon; Butsch Kovacic, Melinda; Nelson, Adam S; Myers, Kasiani C; Mehta, Parinda A; Davies, Stella M; Wells, Susanne I (2018. ) Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know.Viruses, , 10 (1 ) , More Information

Smith, Eric A; Krumpelbeck, Eric F; Jegga, Anil G; Prell, Malte; Matrka, Marie M; Kappes, Ferdinand; Greis, Kenneth D; Ali, Abdullah M; Meetei, Amom R; Wells, Susanne I (2018. ) The nuclear DEK interactome supports multi-functionality.Proteins, , 86 (1 ) ,88-97 More Information

Myers, Kasiani C; Sauter, Sharon; Zhang, Xue; Bleesing, Jacob J; Davies, Stella M; Wells, Susanne I; Mehta, Parinda A; Kumar, Ashish; Marmer, Daniel; Marsh, Rebecca; Brown, Darron; Butsch Kovacic, Melinda (2017. ) Impaired immune function in children and adults with Fanconi anemia.Pediatric blood & cancer, , 64 (11 ) , More Information

Matrka, Marie C; Watanabe, Miki; Muraleedharan, Ranjithmenon; Lambert, Paul F; Lane, Andrew N; Romick-Rosendale, Lindsey E; Wells, Susanne I (2017. ) Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis.PloS one, , 12 (5 ) ,e0177952 More Information

Smith, Eric A; Kumar, Bhavna; Komurov, Kakajan; Smith, Stephen M; Brown, Nicole V; Zhao, Songzhu; Kumar, Pawan; Teknos, Theodoros N; Wells, Susanne I (2017. ) DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma.Oncotarget, , 8 (14 ) ,23414-23426 More Information

Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I (2017. ) DEK is required for homologous recombination repair of DNA breaks.Scientific reports, , 7 ,44662 More Information

Koncar, Robert F; Chu, Zhengtao; Romick-Rosendale, Lindsey E; Wells, Susanne I; Chan, Timothy A; Qi, Xiaoyang; Bahassi, El Mustapha (2017. ) PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas.Oncotarget, , 8 (9 ) ,15827-15837 More Information

Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I (2016. ) Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Clinical cancer research : an official journal of the American Association for Cancer Research, , 22 (8 ) ,2062-73 More Information

Tuttle, Traci R; Mierzwa, Michelle L; Wells, Susanne I; Fox, Sejal R; Ben-Jonathan, Nira (2016. ) The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma.Cancer letters, , 370 (2 ) ,279-85 More Information

Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I (2016. ) Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage.Stem cell reports, , 6 (1 ) ,44-54 More Information

Adams, Allie K; Bolanos, Lyndsey C; Dexheimer, Phillip J; Karns, Rebekah A; Aronow, Bruce J; Komurov, Kakajan; Jegga, Anil G; Casper, Keith A; Patil, Yash J; Wilson, Keith M; Starczynowski, Daniel T; Wells, Susanne I (2015. ) IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival.Oncotarget, , 6 (41 ) ,43395-407 More Information

Toptan, Tuna; Brusadelli, Marion G; Turpin, Brian; Witte, David P; Surrallés, Jordi; Velleuer, Eunike; Schramm, Martin; Dietrich, Ralf; Brakenhoff, Ruud H; Moore, Patrick S; Chang, Yuan; Wells, Susanne I (2018. ) Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma.PloS one, , 13 (12 ) ,e0209235 More Information

Nicol, Alcina F; de Andrade, Cecilia Vianna; Gomes, Saint Clair; Brusadelli, Marion G; Lodin, Hannah M; Wells, Susanne I; Nuovo, Gerard J (2018. ) The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix.Annals of diagnostic pathology, , 38 ,115-122 More Information

Trisno, Stephen L; Philo, Katherine E D; McCracken, Kyle W; Catá, Emily M; Ruiz-Torres, Sonya; Rankin, Scott A; Han, Lu; Nasr, Talia; Chaturvedi, Praneet; Rothenberg, Marc E; Mandegar, Mohammad A; Wells, Susanne I; Zorn, Aaron M; Wells, James M (2018. ) Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification.Cell stem cell, , 23 (4 ) ,501-515.e7 More Information

Nuovo, Gerard J; de Andrade, Cecilia Vianna; Wells, Susanne I; Brusadelli, Marion; Nicol, Alcina F (2018. ) New biomarkers of human papillomavirus infection in acute cervical intraepithelial neoplasia.Annals of diagnostic pathology, , 36 ,21-27 More Information

Mehta, Parinda A; Sauter, Sharon; Zhang, Xue; Davies, Stella M; Wells, Suzanne I; Myers, Kasiani C; Panicker, Gitika; Unger, Elizabeth R; Butsch Kovacic, Melinda (2017. ) Antibody response to human papillomavirus vaccination and natural exposure in individuals with Fanconi Anemia.Vaccine, , 35 (48 Pt B ) ,6712-6719 More Information

Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I (2015. ) The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.Oncogene, , 34 (18 ) ,2325-36 More Information

Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I (2015. ) DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.Oncogene, , 34 (7 ) ,868-77 More Information

Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I (2011. ) The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer.Oncogene, , 30 (24 ) ,2741-52 More Information

Blanchard, Carine; Stucke, Emily M; Burwinkel, Karen; Caldwell, Julie M; Collins, Margaret H; Ahrens, Annette; Buckmeier, Bridget K; Jameson, Sean C; Greenberg, Allison; Kaul, Ajay; Franciosi, James P; Kushner, Jonathan P; Martin, Lisa J; Putnam, Philip E; Abonia, J Pablo; Wells, Suzanne I; Rothenberg, Marc E (2010. ) Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.Journal of immunology (Baltimore, Md. : 1950), , 184 (7 ) ,4033-41 More Information

Hoskins, E E; Morris, T A; Higginbotham, J M; Spardy, N; Cha, E; Kelly, P; Williams, D A; Wikenheiser-Brokamp, K A; Duensing, S; Wells, S I (2009. ) Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture.Oncogene, , 28 (5 ) ,674-85 More Information

Hoskins, E E; Gunawardena, R W; Habash, K B; Wise-Draper, T M; Jansen, M; Knudsen, E S; Wells, S I (2008. ) Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway.Oncogene, , 27 (35 ) ,4798-808 More Information

van Harten, Anne M; Poell, Jos B; Buijze, Marijke; Brink, Arjen; Wells, Susanne I; René Leemans, C; Wolthuis, Rob M F; Brakenhoff, Ruud H (2019. ) Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.Oral oncology, , 98 ,53-61 More Information

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I (2018. ) Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy.International journal of particle therapy, , 5 (1 ) ,40-48 More Information

Nowrouzi, Ali; Sertorio, Mathieu G; Akbarpour, Mahdi; Knoll, Maximillian; Krunic, Damir; Kuhar, Matthew; Schwager, Christian; Brons, Stephan; Debus, Jürgen; Wells, Susanne I; Wells, James M; Abdollahi, Amir (2020. ) Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids.Cancers, , 12 (2 ) , More Information

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; Shelby McCauley, ; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I (2020. ) Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, , More Information

Marion, William; Boettcher, Steffen; Ruiz-Torres, Sonya; Lummertz da Rocha, Edroaldo; Lundin, Vanessa; Morris, Vivian; Chou, Stephanie; Zhao, Anna M; Kubaczka, Caroline; Aumais, Olivia; Zhang, Yosra; Shimamura, Akiko; Schlaeger, Thorsten M; North, Trista E; Ebert, Benjamin L; Wells, Susanne I; Daley, George Q; Rowe, R Grant (2020. ) An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation.Blood advances, , 4 (19 ) ,4679-4692 More Information

Wu, Yvonne W; Comstock, Bryan A; Gonzalez, Fernando F; Mayock, Dennis E; Goodman, Amy M; Maitre, Nathalie L; Chang, Taeun; Van Meurs, Krisa P; Lampland, Andrea L; Bendel-Stenzel, Ellen; Mathur, Amit M; Wu, Tai-Wei; Riley, David; Mietzsch, Ulrike; Chalak, Lina; Flibotte, John; Weitkamp, Joern-Hendrik; Ahmad, Kaashif A; Yanowitz, Toby D; Baserga, Mariana; Poindexter, Brenda B; Rogers, Elizabeth E; Lowe, Jean R; Kuban, Karl C K; O'Shea, T Michael; Wisnowski, Jessica L; McKinstry, Robert C; Bluml, Stefan; Bonifacio, Sonia; Benninger, Kristen L; Rao, Rakesh; Smyser, Christopher D; Sokol, Gregory M; Merhar, Stephanie; Schreiber, Michael D; Glass, Hannah C; Heagerty, Patrick J; Juul, Sandra E (2022. ) Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.The New England journal of medicine, , 387 (2 ) ,148-159 More Information

Muratoglu, Selen C; Charette, Marc F; Galis, Zorina S; Greenstein, Adam S; Daugherty, Alan; Joutel, Anne; Kozel, Beth A; Wilcock, Donna M; Collins, Emily C; Sorond, Farzaneh A; Howell, Gareth R; Hyacinth, Hyacinth I; Lloyd, Kent K C; Stenmark, Kurt R; Boehm, Manfred; Kahn, Mark L; Corriveau, Roderick; Wells, Sara; Bussey, Timothy J; Sukoff Rizzo, Stacey J; Iruela-Arispe, M Luisa (2022. ) Perspectives on Cognitive Phenotypes and Models of Vascular Disease.Arteriosclerosis, thrombosis, and vascular biology, , 42 (7 ) ,831-838 More Information

Chihanga, Tafadzwa; Vicente-Muñoz, Sara; Ruiz-Torres, Sonya; Pal, Bidisha; Sertorio, Mathieu; Andreassen, Paul R; Khoury, Ruby; Mehta, Parinda; Davies, Stella M; Lane, Andrew N; Romick-Rosendale, Lindsey E; Wells, Susanne I (2022. ) Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia.Cancers, , 14 (8 ) , More Information

Roohollahi, Khashayar; de Jong, Yvonne; Pai, Govind; Zaini, Mohamad Amr; de Lint, Klaas; Sie, Daoud; Rooimans, Martin A; Rockx, Davy; Hoskins, Elizabeth E; Ameziane, Najim; Wolthuis, Rob; Joenje, Hans; Wells, Susanne I; Dorsman, Josephine (2022. ) Publisher Correction: BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.Scientific reports, , 12 (1 ) ,5768 More Information

Silva de Araujo, Bruno Eduardo; Velleuer, Eunike; Dietrich, Ralf; Pomjanski, Natalia; de Santana Almeida Araujo, Isabela Karoline; Schlensog, Martin; Wells, Susanne Irmtraud; Dorsman, Josephine Christine; Schramm, Martin (2022. ) Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia-Proof of concept.Clinical and experimental dental research, , 8 (1 ) ,108-116 More Information

Roohollahi, Khashayar; de Jong, Yvonne; Pai, Govind; Zaini, Mohamad Amr; de Lint, Klaas; Sie, Daoud; Rooimans, Martin A; Rockx, Davy; Hoskins, Elizabeth E; Ameziane, Najim; Wolthuis, Rob; Joenje, Hans; Wells, Susanne I; Dorsman, Josephine (2022. ) BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.Scientific reports, , 12 (1 ) ,45 More Information

Ruiz-Torres, Sonya; Lambert, Paul F; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2021. ) Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells.Molecular biology reports, , 48 (8 ) ,6213-6222 More Information

Bedard, Mary C; de Alarcon, Alessandro; Kou, Yann-Fuu; Lee, David; Sestito, Alexandra; Duggins, Angela L; Brusadelli, Marion; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I; Smith, David F (2021. ) HPV Strain Predicts Severity of Juvenile-Onset Recurrent Respiratory Papillomatosis with Implications for Disease Screening.Cancers, , 13 (11 ) , More Information

Sauter, Sharon L; Zhang, Xue; Romick-Rosendale, Lindsey; Wells, Susanne I; Myers, Kasiani C; Brusadelli, Marion G; Poff, Charles B; Brown, Darron R; Panicker, Gitika; Unger, Elizabeth R; Mehta, Parinda A; Bleesing, Jack; Davies, Stella M; Butsch Kovacic, Melinda (2021. ) Human Papillomavirus Oral- and Sero- Positivity in Fanconi Anemia.Cancers, , 13 (6 ) , More Information

Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I (2021. ) Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.Cell stem cell, , 28 (3 ) ,424-435.e6 More Information

Cunningham, Shannon; McCauley, Shelby; Vairamani, Kanimozhi; Speth, Joseph; Girdhani, Swati; Abel, Eric; Sharma, Ricky A; Perentesis, John P; Wells, Susanne I; Mascia, Anthony; Sertorio, Mathieu (2021. ) FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice.Cancers, , 13 (5 ) , More Information

Bartlett, Allison L; Romick-Rosendale, Lindsey; Nelson, Adam; Abdullah, Sheyar; Luebbering, Nathan; Bartlett, Jamen; Brusadelli, Marion; Palumbo, Joseph S; Lake, Kelly; Litts, Bridget; Duell, Alexandra; Urbanski, Annette; Lane, Adam; Myers, Kasiani C; Wells, Susanne I; Davies, Stella M (2021. ) Tryptophan metabolism is dysregulated in individuals with Fanconi anemia.Blood advances, , 5 (1 ) ,250-261 More Information

Bedard, Mary C; Brusadelli, Marion G; Carlile, Adrean; Ruiz-Torres, Sonya; Lodin, Hannah; Lee, Denis; Kofron, Matthew; Lambert, Paul F; Lane, Adam; Ameziane, Najim; Bahassi, El Mustapha; Wikenheiser-Brokamp, Kathryn A; de Alarcon, Alessandro; Smith, David F; Wells, Susanne I (2021. ) Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis.Viruses, , 13 (1 ) , More Information

Marion, William; Koppe, Tiago; Chen, Chun-Chin; Wang, Dahai; Frenis, Katie; Fierstein, Sara; Sensharma, Prerana; Aumais, Olivia; Peters, Michael; Ruiz-Torres, Sonya; Chihanga, Tafadzwa; Boettcher, Steffen; Shimamura, Akiko; Bauer, Daniel E; Schlaeger, Thorsten; Wells, Susanne I; Ebert, Benjamin L; Starczynowski, Daniel; da Rocha, Edroaldo Lummertz; Rowe, R Grant (2023. ) RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia.Leukemia, , 37 (8 ) ,1698-1708 More Information

Nguyen, Hiep Tai; Tang, Weiliang; Webster, Andrew L H; Whiteaker, Jeffrey R; Chandler, Christopher M; Errazquin, Ricardo; Roohollahi, Khashayar; Fritzke, Madeline; Hoskins, Elizabeth E; Jonlin, Erica; Wakefield, Leslie; Sullivan, Lucas B; Chen, Eleanor Y; Dorsman, Josephine; Brakenhoff, Ruud; Paulovich, Amanda G; Grompe, Markus; Garcia-Escudero, Ramon; Wells, Susanne I; Smogorzewska, Agata; Monnat, Raymond J (2023. ) Fanconi anemia-isogenic head and neck cancer cell line pairs: A basic and translational science resource.International journal of cancer, , 153 (1 ) ,183-196 More Information

Hunt, Brian G; Davis, James C; Fox, Levi H; Vicente-Muñoz, Sara; Lester, Carissa; Wells, Susanne I; Waltz, Susan E (2023. ) RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence.Oncogene, , 42 (21 ) ,1716-1727 More Information

Bedard, Mary C; Chihanga, Tafadzwa; Carlile, Adrean; Jackson, Robert; Brusadelli, Marion G; Lee, Denis; VonHandorf, Andrew; Rochman, Mark; Dexheimer, Phillip J; Chalmers, Jeffrey; Nuovo, Gerard; Lehn, Maria; Williams, David E J; Kulkarni, Aditi; Carey, Molly; Jackson, Amanda; Billingsley, Caroline; Tang, Alice; Zender, Chad; Patil, Yash; Wise-Draper, Trisha M; Herzog, Thomas J; Ferris, Robert L; Kendler, Ady; Aronow, Bruce J; Kofron, Matthew; Rothenberg, Marc E; Weirauch, Matthew T; Van Doorslaer, Koenraad; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Adam, Mike; Steven Potter, S; Wells, Susanne I (2023. ) Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer.Nature communications, , 14 (1 ) ,1975 More Information

Webster, Andrew L H; Sanders, Mathijs A; Patel, Krupa; Dietrich, Ralf; Noonan, Raymond J; Lach, Francis P; White, Ryan R; Goldfarb, Audrey; Hadi, Kevin; Edwards, Matthew M; Donovan, Frank X; Hoogenboezem, Remco M; Jung, Moonjung; Sridhar, Sunandini; Wiley, Tom F; Fedrigo, Olivier; Tian, Huasong; Rosiene, Joel; Heineman, Thomas; Kennedy, Jennifer A; Bean, Lorenzo; Rosti, Rasim O; Tryon, Rebecca; Gonzalez, Ashlyn-Maree; Rosenberg, Allana; Luo, Ji-Dung; Carroll, Thomas S; Shroff, Sanjana; Beaumont, Michael; Velleuer, Eunike; Rastatter, Jeff C; Wells, Susanne I; Surrallés, Jordi; Bagby, Grover; MacMillan, Margaret L; Wagner, John E; Cancio, Maria; Boulad, Farid; Scognamiglio, Theresa; Vaughan, Roger; Beaumont, Kristin G; Koren, Amnon; Imielinski, Marcin; Chandrasekharappa, Settara C; Auerbach, Arleen D; Singh, Bhuvanesh; Kutler, David I; Campbell, Peter J; Smogorzewska, Agata (2022. ) Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.Nature, , 612 (7940 ) ,495-502 More Information

Vicente-Muñoz, Sara; Hunt, Brian G; Lange, Taylor E; Wells, Susanne I; Waltz, Susan E (2022. ) NMR-based metabolomic analysis identifies RON-DEK-β-catenin dependent metabolic pathways and a gene signature that stratifies breast cancer patient survival.PloS one, , 17 (9 ) ,e0274128 More Information

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