Laura Wexler , MD

Bachelor's Degree: Barnard College, Columbia University 1967 (Biology (with Honors))

Medical Degree: Washington University School of Medicine 1971

Residency : Boston City Hospital, Harvard Medical Service 1973 (Internal Medicine )

Senior Resident : Massachusetts General Hospital 1974 (Internal Medicine)

Clinical & Research Fellowship: Massachusetts General Hospital 1976 (Cardiology )

Fellow : Executive Leadership Academic Medicine MCP-Hahnemann University 2000

American Board of Internal Medicine (Cardiovascular Disease) (Certification Date: 11-10-1981 ) - (Recertification Date: to 05-06-2008 )

American Board of Internal Medicine (Certification Date: 06-19-1974 )

Cardiovascular Disease

Internal Medicine

Heart Disease in Women, Sleep Apnea in Patients with Heart Failure.

1976 -1987 Assistant Professor of Medicine, Boston University School of Medicine, Boston, MA

1987 -1992 Associate Professor of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1992 - Professor of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

2001 - Associate Dean, Student Affairs and Admissions, University of Cincinnati College of Medicine, Cincinnati, OH

2008 - Senior Associate Dean, Student Affairs and Admissions, University of Cincinnati College of Medicine, Cincinnati, OH

Investigators:LF Wexler 2005 Office of Medical Education Research Innovation Grant Web-based ECG Instruction

Investigators:LF Wexler 2004 Dean's Discovery Fund Medical Student Summer Research Programs

Investigators:LF Wexler 1998 -2000 Ciba-Geigy VALHEFT: Multi-country, randomized, double blind, parallel, placebo-controlled trial to assess the effect of Valsartan on morbidity and mortality, signs and symptoms and quality of life in patients with stable, chronic CHF Role:Local PI

Investigators:LF Wexler 1996 -2000 Parke-David Pharmaceutical Research Role:PI

Grant: #N01-WH-4-2126 Investigators:LF Wexler 1995 -2000 Women's Health Initiative, Clinical Center, Cardiology Consultant

Peer Reviewed Publications

Robins, S J; Collins, D; Wittes, J T; Papademetriou, V; Deedwania, P C; Schaefer, E J; McNamara, J R; Kashyap, M L; Hershman, J M; Wexler, L F; Rubins, H B (2001. ) Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. JAMA : the journal of the American Medical Association, , 285 (12 ) ,1585-91

Wexler, L F; Blaustein, A S; Lavori, P W; Lehmann, K G; Wade, M; Boden, W E (2001. ) Non-Q-wave myocardial infarction following thrombolytic therapy: a comparison of outcomes in patients randomized to invasive or conservative post-infarct assessment strategies in the Veterans Affairs non-Q-wave Infarction Strategies In-Hospital (VANQWISH) Trial. Journal of the American College of Cardiology, , 37 (1 ) ,19-25

Wexler, L F (1999. ) Studies of acute coronary syndromes in women--lessons for everyone.The New England journal of medicine, , 341 (4 ) ,275-6 More Information

Shaffer, J; Simbartl, L; Render, M L; Snow, E; Chaney, C; Nishiyama, H; Rauf, G C; Wexler, L F (1998. ) Patients with stable chronic obstructive pulmonary disease can safely undergo intravenous dipyridamole thallium-201 imaging.American heart journal, , 136 (2 ) ,307-13 More Information

Boden, W E; O'Rourke, R A; Crawford, M H; Blaustein, A S; Deedwania, P C; Zoble, R G; Wexler, L F; Kleiger, R E; Pepine, C J; Ferry, D R; Chow, B K; Lavori, P W (1998. ) Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH) Trial Investigators.The New England journal of medicine, , 338 (25 ) ,1785-92 More Information

Hashkes, Philip J; Wexler, Laura F; Passo, Murray H (1997. ) Coronary Artery Disease in Systemic Lupus Erythematosus: Risk Factors, Assessment, and Prevention. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, , 3 (4 ) ,203-210

Shaffer, J; Wexler, L F (1995. ) Reducing low-density lipoprotein cholesterol levels in an ambulatory care system. Results of a multidisciplinary collaborative practice lipid clinic compared with traditional physician-based care. Archives of internal medicine, , 155 (21 ) ,2330-5

Blaustein, A S; Hoit, B D; Wexler, L F; Ashraf, M; Ramrakhyani, K; Matoba, R; Gabel, M; Millard, R W (1995. ) Characteristics of chronic left ventricular dysfunction induced by coronary embolization in a canine model. The American journal of cardiovascular pathology, , 5 (1 ) ,32-48

Adolph, E A; Lacy, W O; Hermoni, Y I; Wexler, L F; Javaheri, S (1992. ) Reversible orthodeoxia and platypnea due to right-to-left intracardiac shunting related to pericardial effusion. Annals of internal medicine, , 116 (2 ) ,138-9

Wexler, L F; Grice, W N; Huntington, M; Plehn, J F; Apstein, C S (1989. ) Coronary hypertension and diastolic compliance in isolated rabbit hearts. Hypertension, , 13 (6 Pt 1 ) ,598-606

Goldenberg, A M; Wexler, L F (1988. ) Quinine overdose: review of toxicity and treatment. Clinical cardiology, , 11 (10 ) ,716-8

Wexler, L F; Lorell, B H; Momomura, S; Weinberg, E O; Ingwall, J S; Apstein, C S (1988. ) Enhanced sensitivity to hypoxia-induced diastolic dysfunction in pressure-overload left ventricular hypertrophy in the rat: role of high-energy phosphate depletion. Circulation research, , 62 (4 ) ,766-75

Isoyama, S; Apstein, C S; Wexler, L F; Grice, W N; Lorell, B H (1987. ) Acute decrease in left ventricular diastolic chamber distensibility during simulated angina in isolated hearts. Circulation research, , 61 (6 ) ,925-33

Wexler, L F; Weinberg, E O; Ingwall, J S; Apstein, C S (1986. ) Acute alterations in diastolic left ventricular chamber distensibility: mechanistic differences between hypoxemia and ischemia in isolated perfused rabbit and rat hearts. Circulation research, , 59 (5 ) ,515-28

Lorell, B H; Wexler, L F; Momomura, S; Weinberg, E; Apstein, C S (1986. ) The influence of pressure overload left ventricular hypertrophy on diastolic properties during hypoxia in isovolumically contracting rat hearts. Circulation research, , 58 (5 ) ,653-63

Cameron, A; Kemp, H G; Fisher, L D; Gosselin, A; Judkins, M P; Kennedy, J W; Lesperance, J; Mudd, J G; Ryan, T J; Silverman, J F; Tristani, F; Vlietstra, R E; Wexler, L F (1983. ) Left main coronary artery stenosis: angiographic determination. Circulation, , 68 (3 ) ,484-9

Wexler, L F; Pohost, G M; Rubenstein, J J; O'Keefe, D D; Vezeridis, M P; Daggett, W M (1982. ) The relationship of the first heart sound to mitral valve closure in dogs. Circulation, , 66 (1 ) ,235-43

Wexler, L F; Lesperance, J; Ryan, T J; Bourassa, M G; Fisher, L D; Maynard, C; Kemp, H G; Cameron, A; Gosselin, A J; Judkins, M P (1982. ) Interobserver variability in interpreting contrast left ventriculograms (CASS). Catheterization and cardiovascular diagnosis, , 8 (4 ) ,341-55

Lee, D C; Johnson, R A; Boucher, C A; Wexler, L F; McEnany, M T (1977. ) Angiographic predictors of survival following left ventricular aneurysmectomy. Circulation, , 56 (3 Suppl ) ,II12-8

Wexler, L F; Pohost, G M (1976. ) Hemodynamic monitoring: noninvasive techniques. Anesthesiology, , 45 (2 ) ,156-83

Peyru, G; Wexler, L F; Novick, R P (1969. ) Naturally occurring penicillinase plasmids in Staphylococcus aureus. Journal of bacteriology, , 98 (1 ) ,215-21

Javaheri, Shahrokh; Shukla, Rakesh; Wexler, Laura (2012. ) Association of smoking, sleep apnea, and plasma alkalosis with nocturnal ventricular arrhythmias in men with systolic heart failure.Chest, , 141 (6 ) ,1449-1456 More Information

Javaheri, Shahrokh; Shukla, Rakesh; Zeigler, Haoyue; Wexler, Laura (2007. ) Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure.Journal of the American College of Cardiology, , 49 (20 ) ,2028-34 More Information

Wexler, Laura; Javaheri, Shahrokh (2005. ) Sleep apnea is linked to heart failure, but does treatment improve outcome?.Cleveland Clinic journal of medicine, , 72 (10 ) ,929-36 More Information

Javaheri, Shahrokh; Wexler, Laura (2005. ) Prevalence and treatment of breathing disorders during sleep in patients with heart failure.Current treatment options in cardiovascular medicine, , 7 (4 ) ,295-306 More Information

Javaheri, S; Parker, T J; Liming, J D; Corbett, W S; Nishiyama, H; Wexler, L; Roselle, G A (1998. ) Sleep apnea in 81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations.Circulation, , 97 (21 ) ,2154-9 More Information

Javaheri, S; Parker, T J; Wexler, L; Liming, J D; Lindower, P; Roselle, G A (1996. ) Effect of theophylline on sleep-disordered breathing in heart failure.The New England journal of medicine, , 335 (8 ) ,562-7 More Information

Javaheri, S; Parker, T J; Wexler, L; Michaels, S E; Stanberry, E; Nishyama, H; Roselle, G A (1995. ) Occult sleep-disordered breathing in stable congestive heart failure.Annals of internal medicine, , 122 (7 ) ,487-92 More Information

1970 Alpha Omega Alpha Washington University School of Medicine

1977 Residents Teaching Award Boston University School of Medicine

1994 Residents Teaching Award University of Cincinnati College of Medicine

2001 Samuel Kaplan, M.D. Visionary Award American Heart Association

2007 Dean's Award for Excellence in Teaching University of Cincinnati College of Medicine

2007 Silver Apples: Best Teacher of the Year, 2nd place Awarded by the second year class, University of Cincinnati College of Medicine

2009 Silver Apples: Best Teacher of the Year, 2nd place Awarded by the second year class, University of Cincinnati College of Medicine

heart, cardiac, heart disease, cardiovascular, heart disease in women, sleep apnea, cardiology

Academic - Internal Medicine
Medical Sciences Building Room 3363
Cincinnati  Ohio, 45267
Phone: (513)558-5575
laura.wexler@uc.edu