Kathryn Wikenheiser-Brokamp

Kathryn A. Wikenheiser-Brokamp , MD, PhD

Associate Professor-Affiliate

Education

Medical Degree: University of Cincinnati College of Medicine Cincinnati, OH, 1996

Doctorate: Cincinnati Children's Hospital Medical Center/University of Cincinnati College of Medicine Cincinnati, OH, 1994 (Developmental Biology)

Residency: Washington University-Barnes/Jewish Hospital St. Louis, MO, 2002 (Anatomic Pathology )

Clinical Trainee: Washington University St. Louis, MO , 2002

Research and Practice Interests

Pulmonary pathology, lung development, lung cancer

Positions and Work Experience

- Associate Professor, Cincinnati Children's Hospital Medical Center,

Research Support

Investigators:Wikenheiser-Brokamp, Kathryn 01-01-2004 -12-31-2004 American Cancer Society - Ohio Chapter Retinoblastoma Gene Product (Rb) in Lung Carcinogenesis Role:PI Closed 003380-001 Level:Private Non-Profit

Grant: #R01-HL-079193 Investigators:Wikenheiser-Brokamp, Kathryn 04-01-2005 -01-31-2009 National Heart, Lung and Blood Institute Role of the Rb Family in Lung Epithelial Response to Injury Role:PI Closed 003422-001 Level:Federal

Investigators:Wikenheiser-Brokamp, Kathryn 01-01-2005 -12-31-2008 American Cancer Society - National Chapter Role of Retinoblastoma Protein Family in Lung Carcinogenesis Role:PI Active 003443-001 Level:Private Non-Profit

Publications

Peer Reviewed Publications

Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I (2011. ) The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer.Oncogene, , More Information

Hagaman, Jared T; Panos, Ralph J; McCormack, Francis X; Thakar, Charuhas V; Wikenheiser-Brokamp, Kathryn A; Shipley, Ralph T; Kinder, Brent W (2011. ) Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases.Chest, , 139 (2 ) ,353-60 More Information

Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C (2011. ) Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus.Molecular microbiology, , 79 (4 ) ,1045-62 More Information

Simpson, David S; Mason-Richie, Nicole A; Gettler, Caitlin A; Wikenheiser-Brokamp, Kathryn A (2009. ) Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.Cancer research, , 69 (22 ) ,8733-41 More Information

Hill, D Ashley; Ivanovich, Jennifer; Priest, John R; Gurnett, Christina A; Dehner, Louis P; Desruisseau, David; Jarzembowski, Jason A; Wikenheiser-Brokamp, Kathryn A; Suarez, Brian K; Whelan, Alison J; Williams, Gretchen; Bracamontes, Dawn; Messinger, Yoav; Goodfellow, Paul J (2009. ) DICER1 mutations in familial pleuropulmonary blastoma.Science (New York, N.Y.), , 325 (5943 ) ,965 More Information

Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I (2009. ) DEK proto-oncogene expression interferes with the normal epithelial differentiation program.The American journal of pathology, , 174 (1 ) ,71-81 More Information

Young, L.R., Franz, D.N., Nagarkatte, P., Fletcher, C.D.M., Wikenheiser-Brokamp, K.A., Galsky, M.D., Lam, A., Gelfand, M.J., McCormack, F.X. (2009. ) Utility of FDG-PET in lymphangioleiomyomatosis and tuberous sclerosis complex. Chest, , 136 (3 ) ,962-933

Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Fischer, Aryeh; McCormack, Francis X (2016. ) Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome.Annals of the American Thoracic Society, , 13 (3 ) ,371-5 More Information

Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I (2016. ) Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage.Stem cell reports, , 6 (1 ) ,44-54 More Information

Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X (2015. ) Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment.Science translational medicine, , 7 (313 ) ,313ra181 More Information

Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G (2015. ) Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships.The Journal of pediatrics, , 167 (3 ) ,506-7.e1 More Information

Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X (2015. ) Diffuse Cystic Lung Disease. Part II.American journal of respiratory and critical care medicine, , 192 (1 ) ,17-29 More Information

Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X (2015. ) Diffuse Cystic Lung Disease. Part I.American journal of respiratory and critical care medicine, , 191 (12 ) ,1354-66 More Information

Wagh, Purnima K; Gardner, Margaret A; Ma, Xiaolan; Callahan, Melissa; Shannon, John M; Wert, Susan E; Messinger, Yoav H; Dehner, Louis P; Hill, D Ashley; Wikenheiser-Brokamp, Kathryn A (2015. ) Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma.The Journal of pathology, , 236 (1 ) ,41-52 More Information

Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmüller, Lisa; Hanenberg, Helmut; Andreassen, Paul R; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura E; Wells, Susanne I (2015. ) Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research, , 21 (8 ) ,1962-72 More Information

Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I (2015. ) DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.Oncogene, , 34 (7 ) ,868-77 More Information

Akeno, N; Miller, A L; Ma, X; Wikenheiser-Brokamp, K A (2015. ) p53 suppresses carcinoma progression by inhibiting mTOR pathway activation.Oncogene, , 34 (5 ) ,589-99 More Information

McCauley, Heather A; Liu, Chia-Yang; Attia, Aria C; Wikenheiser-Brokamp, Kathryn A; Zhang, Yujin; Whitsett, Jeffrey A; Guasch, Géraldine (2014. ) TGF? signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium.Development (Cambridge, England), , 141 (23 ) ,4628-39 More Information

Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I (2014. ) High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.Journal of virology, , 88 (19 ) ,11315-26 More Information

Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M (2013. ) Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis.American journal of respiratory and critical care medicine, , 188 (9 ) ,1167-70 More Information

Alsidawi, S; Morris, J C; Wikenheiser-Brokamp, K A; Starnes, S L; Karim, N A (2013. ) Mucoepidermoid carcinoma of the lung: a case report and literature review.Case reports in oncological medicine, , 2013 ,625243 More Information

Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Byrnes, Sue; McCormack, Francis X (2012. ) Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis.Frontiers of medicine, , 6 (4 ) ,395-405 More Information

Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; McCormack, Francis X (2012. ) Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment.Seminars in respiratory and critical care medicine, , 33 (5 ) ,486-97 More Information

Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) Future directions and treatment strategies for head and neck squamous cell carcinomas.Translational research : the journal of laboratory and clinical medicine, , 160 (3 ) ,167-77 More Information

Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) The fanconi anemia pathway limits human papillomavirus replication.Journal of virology, , 86 (15 ) ,8131-8 More Information

Gupta, Nishant; Aragaki, Alejandro; Wikenheiser-Brokamp, Kathryn A; Benzaquen, Sadia; Panos, Ralph J (2012. ) Occam's razor or Hickam's dictum?.Journal of bronchology & interventional pulmonology, , 19 (3 ) ,216-9 More Information

Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.PloS one, , 7 (10 ) ,e46985 More Information

Sen, M; Akeno, N; Reece, A; Miller, A L; Simpson, D S; Wikenheiser-Brokamp, K A (2017. ) p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function.Oncogenesis, , 6 (4 ) ,e320 More Information

Sriprasart, Thitiwat; Aragaki, Alejandro; Baughman, Robert; Wikenheiser-Brokamp, Kathryn; Khanna, Gaurav; Tanase, Daniel; Kirschner, Michelle; Benzaquen, Sadia (2017. ) A Single US Center Experience of Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease With a 2-Scope Technique.Journal of bronchology & interventional pulmonology, , 24 (2 ) ,131-135 More Information

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut (2017. ) Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.Cell reports, , 18 (11 ) ,2608-2621 More Information

Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K (2017. ) Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research.The Journal of pediatrics, , 181 ,5-6.e3 More Information

Xu, Yan; Mizuno, Takako; Sridharan, Anusha; Du, Yina; Guo, Minzhe; Tang, Jie; Wikenheiser-Brokamp, Kathryn A; Perl, Anne-Karina T; Funari, Vincent A; Gokey, Jason J; Stripp, Barry R; Whitsett, Jeffrey A (2016. ) Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.JCI insight, , 1 (20 ) ,e90558 More Information

Osterburg, Andrew R; Nelson, Rebecca L; Yaniv, Benyamin Z; Foot, Rachel; Donica, Walter R F; Nashu, Madison A; Liu, Huan; Wikenheiser-Brokamp, Kathryn A; Moss, Joel; Gupta, Nishant; McCormack, Francis X; Borchers, Michael T (2016. ) NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline.JCI insight, , 1 (16 ) ,e87270 More Information

McCormack, Francis X; Gupta, Nishant; Finlay, Geraldine R; Young, Lisa R; Taveira-DaSilva, Angelo M; Glasgow, Connie G; Steagall, Wendy K; Johnson, Simon R; Sahn, Steven A; Ryu, Jay H; Strange, Charlie; Seyama, Kuniaki; Sullivan, Eugene J; Kotloff, Robert M; Downey, Gregory P; Chapman, Jeffrey T; Han, MeiLan K; D'Armiento, Jeanine M; Inoue, Yoshikazu; Henske, Elizabeth P; Bissler, John J; Colby, Thomas V; Kinder, Brent W; Wikenheiser-Brokamp, Kathryn A; Brown, Kevin K; Cordier, Jean F; Meyer, Cristopher; Cottin, Vincent; Brozek, Jan L; Smith, Karen; Wilson, Kevin C; Moss, Joel (2016. ) Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management.American journal of respiratory and critical care medicine, , 194 (6 ) ,748-61 More Information

Dehner, Louis P; Messinger, Yoav H; Schultz, Kris Ann P; Williams, Gretchen M; Wikenheiser-Brokamp, Kathryn; Hill, D Ashley Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, , 18 (6 ) ,504-11 More Information

Dong, Zhongyun; Meller, Jaroslaw; Succop, Paul; Wang, Jiang; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Lu, Shan (2014. ) Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells.International journal of oncology, , 45 (3 ) ,978-84 More Information

Cundiff, William B; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Kotloff, Robert; Benzaquen, Sadia (2014. ) Successful management of a chronic, refractory bronchopleural fistula with endobronchial valves followed by talc pleurodesis.American journal of respiratory and critical care medicine, , 189 (4 ) ,490-1 More Information

McCormack, Francis X; Wilmott, Clay; Young, Lisa R; Wikenheiser-Brokamp, Kathryn (2013. ) An atoll variant that mocks.American journal of respiratory and critical care medicine, , 188 (1 ) ,110 More Information

Kupert, Elena; Anderson, Marshall; Liu, Yin; Succop, Paul; Levin, Linda; Wang, Jiang; Wikenheiser-brokamp, Kathryn; Chen, Pingping; Pinney, Susan M; Macdonald, Trudy; Dong, Zhongyun; Starnes, Sandra; Lu, Shan (2011. ) Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules.BMC cancer, , 11 ,513 More Information

Mayhew, Christopher N; Carter, Scott L; Fox, Sejal R; Sexton, Charlene R; Reed, Christopher A; Srinivasan, Seetha V; Liu, Xiangdong; Wikenheiser-Brokamp, Kathryn; Boivin, Gregory P; Lee, Ju-Seog; Aronow, Bruce J; Thorgeirsson, Snorri S; Knudsen, Erik S (2007. ) RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.Gastroenterology, , 133 (3 ) ,976-84 More Information

Ciampi, Raffaele; Giordano, Thomas J; Wikenheiser-Brokamp, Kathryn; Koenig, Ronald J; Nikiforov, Yuri E (2007. ) HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.Endocrine-related cancer, , 14 (2 ) ,445-52 More Information

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J (2017. ) Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.Molecular cancer research : MCR, , 15 (10 ) ,1318-1330 More Information

Akeno, Nagako; Reece, Alisa L; Callahan, Melissa; Miller, Ashley L; Kim, Rebecca G; He, Diana; Lane, Adam; Moulton, Jonathan S; Wikenheiser-Brokamp, Kathryn A (2017. ) Trp53 Mutants Drive Neuroendocrine Lung Cancer through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response.Molecular cancer therapeutics, , More Information