Kathryn Wikenheiser-Brokamp

Kathryn A. Wikenheiser-Brokamp

Associate Professor-Affiliate

Education

Medical Degree, University of Cincinnati College of Medicine Cincinnati, OH, 1996

Doctorate, Cincinnati Children's Hospital Medical Center/University of Cincinnati College of Medicine Cincinnati, OH, 1994 (Developmental Biology)

Residency, Washington University-Barnes/Jewish Hospital St. Louis, MO, 2002 (Anatomic Pathology )

Clinical Trainee, Washington University St. Louis, MO , 2002

Positions and Work Experience

- Associate Professor, Cincinnati Children's Hospital Medical Center,

Research and Practice Interests

Pulmonary pathology, lung development, lung cancer

Research Support

Investigators:Wikenheiser-Brokamp, Kathryn 01-01-2004 -12-31-2004 American Cancer Society - Ohio Chapter Retinoblastoma Gene Product (Rb) in Lung Carcinogenesis Role:PI Closed 003380-001 Level:Private Non-Profit

Grant: #R01-HL-079193 Investigators:Wikenheiser-Brokamp, Kathryn 04-01-2005 -01-31-2009 National Heart, Lung and Blood Institute Role of the Rb Family in Lung Epithelial Response to Injury Role:PI Closed 003422-001 Level:Federal

Investigators:Wikenheiser-Brokamp, Kathryn 01-01-2005 -12-31-2008 American Cancer Society - National Chapter Role of Retinoblastoma Protein Family in Lung Carcinogenesis Role:PI Active 003443-001 Level:Private Non-Profit

Publications

Peer Reviewed Publications

Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I (2011. )The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer.Oncogene, ,

Hagaman, Jared T; Panos, Ralph J; McCormack, Francis X; Thakar, Charuhas V; Wikenheiser-Brokamp, Kathryn A; Shipley, Ralph T; Kinder, Brent W (2011. )Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases.Chest, ,139 (2 ),353-60

Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C (2011. )Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus.Molecular microbiology, ,79 (4 ),1045-62

Simpson, David S; Mason-Richie, Nicole A; Gettler, Caitlin A; Wikenheiser-Brokamp, Kathryn A (2009. )Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.Cancer research, ,69 (22 ),8733-41

Hill, D Ashley; Ivanovich, Jennifer; Priest, John R; Gurnett, Christina A; Dehner, Louis P; Desruisseau, David; Jarzembowski, Jason A; Wikenheiser-Brokamp, Kathryn A; Suarez, Brian K; Whelan, Alison J; Williams, Gretchen; Bracamontes, Dawn; Messinger, Yoav; Goodfellow, Paul J (2009. )DICER1 mutations in familial pleuropulmonary blastoma.Science (New York, N.Y.), ,325 (5943 ),965

Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I (2009. )DEK proto-oncogene expression interferes with the normal epithelial differentiation program.The American journal of pathology, ,174 (1 ),71-81

Young, L.R., Franz, D.N., Nagarkatte, P., Fletcher, C.D.M., Wikenheiser-Brokamp, K.A., Galsky, M.D., Lam, A., Gelfand, M.J., McCormack, F.X. (2009. )Utility of FDG-PET in lymphangioleiomyomatosis and tuberous sclerosis complex. Chest, ,136 (3 ),962-933

Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Fischer, Aryeh; McCormack, Francis X (2016. )Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome.Annals of the American Thoracic Society, ,13 (3 ),371-5

Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I (2016. )Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage.Stem cell reports, ,6 (1 ),44-54

Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X (2015. )Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment.Science translational medicine, ,7 (313 ),313ra181

Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G (2015. )Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships.The Journal of pediatrics, ,167 (3 ),506-7.e1

Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X (2015. )Diffuse Cystic Lung Disease. Part II.American journal of respiratory and critical care medicine, ,192 (1 ),17-29

Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X (2015. )Diffuse Cystic Lung Disease. Part I.American journal of respiratory and critical care medicine, ,191 (12 ),1354-66

Wagh, Purnima K; Gardner, Margaret A; Ma, Xiaolan; Callahan, Melissa; Shannon, John M; Wert, Susan E; Messinger, Yoav H; Dehner, Louis P; Hill, D Ashley; Wikenheiser-Brokamp, Kathryn A (2015. )Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma.The Journal of pathology, ,236 (1 ),41-52

Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmüller, Lisa; Hanenberg, Helmut; Andreassen, Paul R; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura E; Wells, Susanne I (2015. )Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research, ,21 (8 ),1962-72

Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I (2015. )DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.Oncogene, ,34 (7 ),868-77

Akeno, N; Miller, A L; Ma, X; Wikenheiser-Brokamp, K A (2015. )p53 suppresses carcinoma progression by inhibiting mTOR pathway activation.Oncogene, ,34 (5 ),589-99

McCauley, Heather A; Liu, Chia-Yang; Attia, Aria C; Wikenheiser-Brokamp, Kathryn A; Zhang, Yujin; Whitsett, Jeffrey A; Guasch, Géraldine (2014. )TGF? signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium.Development (Cambridge, England), ,141 (23 ),4628-39

Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I (2014. )High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.Journal of virology, ,88 (19 ),11315-26

Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M (2013. )Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis.American journal of respiratory and critical care medicine, ,188 (9 ),1167-70

Alsidawi, S; Morris, J C; Wikenheiser-Brokamp, K A; Starnes, S L; Karim, N A (2013. )Mucoepidermoid carcinoma of the lung: a case report and literature review.Case reports in oncological medicine, ,2013 ,625243

Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Byrnes, Sue; McCormack, Francis X (2012. )Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis.Frontiers of medicine, ,6 (4 ),395-405

Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; McCormack, Francis X (2012. )Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment.Seminars in respiratory and critical care medicine, ,33 (5 ),486-97

Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. )Future directions and treatment strategies for head and neck squamous cell carcinomas.Translational research : the journal of laboratory and clinical medicine, ,160 (3 ),167-77

Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. )The fanconi anemia pathway limits human papillomavirus replication.Journal of virology, ,86 (15 ),8131-8

Gupta, Nishant; Aragaki, Alejandro; Wikenheiser-Brokamp, Kathryn A; Benzaquen, Sadia; Panos, Ralph J (2012. )Occam's razor or Hickam's dictum?.Journal of bronchology & interventional pulmonology, ,19 (3 ),216-9

Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. )The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.PloS one, ,7 (10 ),e46985

Sen, M; Akeno, N; Reece, A; Miller, A L; Simpson, D S; Wikenheiser-Brokamp, K A (2017. )p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function.Oncogenesis, ,6 (4 ),e320

Sriprasart, Thitiwat; Aragaki, Alejandro; Baughman, Robert; Wikenheiser-Brokamp, Kathryn; Khanna, Gaurav; Tanase, Daniel; Kirschner, Michelle; Benzaquen, Sadia (2017. )A Single US Center Experience of Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease With a 2-Scope Technique.Journal of bronchology & interventional pulmonology, ,24 (2 ),131-135

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut (2017. )Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.Cell reports, ,18 (11 ),2608-2621

Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K (2017. )Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research.The Journal of pediatrics, ,181 ,5-6.e3

Xu, Yan; Mizuno, Takako; Sridharan, Anusha; Du, Yina; Guo, Minzhe; Tang, Jie; Wikenheiser-Brokamp, Kathryn A; Perl, Anne-Karina T; Funari, Vincent A; Gokey, Jason J; Stripp, Barry R; Whitsett, Jeffrey A (2016. )Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.JCI insight, ,1 (20 ),e90558

Osterburg, Andrew R; Nelson, Rebecca L; Yaniv, Benyamin Z; Foot, Rachel; Donica, Walter R F; Nashu, Madison A; Liu, Huan; Wikenheiser-Brokamp, Kathryn A; Moss, Joel; Gupta, Nishant; McCormack, Francis X; Borchers, Michael T (2016. )NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline.JCI insight, ,1 (16 ),e87270

McCormack, Francis X; Gupta, Nishant; Finlay, Geraldine R; Young, Lisa R; Taveira-DaSilva, Angelo M; Glasgow, Connie G; Steagall, Wendy K; Johnson, Simon R; Sahn, Steven A; Ryu, Jay H; Strange, Charlie; Seyama, Kuniaki; Sullivan, Eugene J; Kotloff, Robert M; Downey, Gregory P; Chapman, Jeffrey T; Han, MeiLan K; D'Armiento, Jeanine M; Inoue, Yoshikazu; Henske, Elizabeth P; Bissler, John J; Colby, Thomas V; Kinder, Brent W; Wikenheiser-Brokamp, Kathryn A; Brown, Kevin K; Cordier, Jean F; Meyer, Cristopher; Cottin, Vincent; Brozek, Jan L; Smith, Karen; Wilson, Kevin C; Moss, Joel (2016. )Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management.American journal of respiratory and critical care medicine, ,194 (6 ),748-61

Dehner, Louis P; Messinger, Yoav H; Schultz, Kris Ann P; Williams, Gretchen M; Wikenheiser-Brokamp, Kathryn; Hill, D Ashley Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, ,18 (6 ),504-11

Dong, Zhongyun; Meller, Jaroslaw; Succop, Paul; Wang, Jiang; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Lu, Shan (2014. )Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells.International journal of oncology, ,45 (3 ),978-84

Cundiff, William B; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Kotloff, Robert; Benzaquen, Sadia (2014. )Successful management of a chronic, refractory bronchopleural fistula with endobronchial valves followed by talc pleurodesis.American journal of respiratory and critical care medicine, ,189 (4 ),490-1

McCormack, Francis X; Wilmott, Clay; Young, Lisa R; Wikenheiser-Brokamp, Kathryn (2013. )An atoll variant that mocks.American journal of respiratory and critical care medicine, ,188 (1 ),110

Kupert, Elena; Anderson, Marshall; Liu, Yin; Succop, Paul; Levin, Linda; Wang, Jiang; Wikenheiser-brokamp, Kathryn; Chen, Pingping; Pinney, Susan M; Macdonald, Trudy; Dong, Zhongyun; Starnes, Sandra; Lu, Shan (2011. )Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules.BMC cancer, ,11 ,513

Mayhew, Christopher N; Carter, Scott L; Fox, Sejal R; Sexton, Charlene R; Reed, Christopher A; Srinivasan, Seetha V; Liu, Xiangdong; Wikenheiser-Brokamp, Kathryn; Boivin, Gregory P; Lee, Ju-Seog; Aronow, Bruce J; Thorgeirsson, Snorri S; Knudsen, Erik S (2007. )RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.Gastroenterology, ,133 (3 ),976-84

Ciampi, Raffaele; Giordano, Thomas J; Wikenheiser-Brokamp, Kathryn; Koenig, Ronald J; Nikiforov, Yuri E (2007. )HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.Endocrine-related cancer, ,14 (2 ),445-52

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J (2017. )Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.Molecular cancer research : MCR, ,15 (10 ),1318-1330

Akeno, Nagako; Reece, Alisa L; Callahan, Melissa; Miller, Ashley L; Kim, Rebecca G; He, Diana; Lane, Adam; Moulton, Jonathan S; Wikenheiser-Brokamp, Kathryn A (2017. )Trp53 Mutants Drive Neuroendocrine Lung Cancer through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response.Molecular cancer therapeutics, ,