Eric S. Wohleb
Research Assistant Professor
Dr. Wohleb received his doctorate in Neuroscience from the Ohio State University in September 2013 under mentorship of Dr. Jonathan Godbout and Dr. John Sheridan at the Institute for Behavioral Medicine Research. Following graduate studies he completed postdoctoral studies in the laboratory of Dr. Ronald Duman at the Yale University School of Medicine from 2013 - 2016. Dr. Wohleb is currently an Assistant Professor in the Department of Psychiatry and Behavioral Neuroscience, with current research focused on the role of neuroimmune systems in the neurobiology of mental health disorders.
Ph.D., The Ohio State University Columbus, Ohio, 2013 (Neuroscience; Neuroimmunology)
B.A., Saint John's University Collegeville, MN, 2008 (Mathematics; Psychology)
Grant: #NARSAD Young Investigator Grant 01-15-2017 -01-14-2019 Brain & Behavior Research Foundation Microglia-mediated Synapse Elimination in Stress-induced Depressive-like Behavior Role:PI
Grant: #R21MH120614 Investigators:Wohleb, Eric 07-01-2019 -05-31-2021 National Institute of Mental Health Microglial brain-derived neurotrophic factor (BDNF) in stress and antidepressant responses Role:PI $200,625.00 Awarded Level:Federal
Peer Reviewed Publications
Wohleb, E. S.; Powell, N. D.; Godbout, J. P.; Sheridan, J. F. (2013. )Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior .J Neurosci, ,33 (34 ),13820-33
Wohleb, E. S.; Patterson, J. M.; Sharma, V.; Quan, N.; Godbout, J. P.; Sheridan, J. F. (2014. )Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior .J Neurosci, ,34 (7 ),2583-91
Wohleb, E. S.; McKim, D. B.; Shea, D. T.; Powell, N. D.; Tarr, A. J.; Sheridan, J. F.; Godbout, J. P. (2014. )Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain .Biol Psychiatry, ,75 (12 ),970-81
Wohleb, E. S.; McKim, D. B.; Sheridan, J. F.; Godbout, J. P. (2015. )Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior .Front Neurosci, ,8 (12 ),447
Fuchikami, M.; Thomas, A.; Liu, R.; Wohleb, E. S.; Land, B. B.; DiLeone, R. J.; Aghajanian, G. K.; Duman, R. S. (2015. )Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions .Proc Natl Acad Sci U S A, ,112 (26 ),8106-11
Wohleb, E. S.; Wu, M.; Gerhard, D. M.; Taylor, S. R.; Picciotto, M. R.; Alreja, M.; Duman, R. S. (2016. )GABA interneurons mediate the rapid antidepressant-like effects of scopolamine .J Clin Invest, ,126 (7 ),2482-94
Wohleb, E. S.; Gerhard, D.; Thomas, A.; Duman, R. S. (2016. )Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine .Curr Neuropharmacol, ,126 (7 ),2482-94
Wohleb, Eric S (2016. )Frontiers in immunology, ,7 ,544
Wohleb, Eric S; Franklin, Tina; Iwata, Masaaki; Duman, Ronald S (2016. ).Nature Reviews Neuroscience, ,17 (8 ),497-511
Wohleb, E.S.; Terwilliger, R.; Duman, C.H.; Duman, R.S. (2017. )Stress-induced neuronal colony stimulating factor-1 provokes microglia-mediated neuronal remodeling and depressive-like behavior .Biological Psychiatry, ,
10-2013-03-2015 Postdoctoral Research Associate, Yale University School of Medicine, ,New Haven, Connecticut, U.S.A.
04-2015-08-2016 Associate Research Scientist, Yale University School of Medicine, ,New Haven, Connecticut, U.S.A.
Research Assistant Professor, Wohleb, Eric Ph.D
Academic - Reading Campus
2120 East Galbraith Road