Eric Wohleb

Eric S. Wohleb

Research Assistant Professor

Professional Summary

Dr. Wohleb received his doctorate in Neuroscience from the Ohio State University in September 2013 under mentorship of Dr. Jonathan Godbout and Dr. John Sheridan at the Institute for Behavioral Medicine Research. Following graduate studies he completed postdoctoral studies in the laboratory of Dr. Ronald Duman at the Yale University School of Medicine from 2013 - 2016. Dr. Wohleb is currently an Assistant Professor in the Department of Psychiatry and Behavioral Neuroscience, with current research focused on the role of neuroimmune systems in the neurobiology of mental health disorders.

Education

Ph.D., The Ohio State University Columbus, Ohio, 2013 (Neuroscience; Neuroimmunology)

B.A., Saint John's University Collegeville, MN, 2008 (Mathematics; Psychology)

Research Support

Grant: #NARSAD Young Investigator Grant 01-15-2017 -01-14-2019 Brain & Behavior Research Foundation Microglia-mediated Synapse Elimination in Stress-induced Depressive-like Behavior Role:PI

Grant: #R21MH120614 Investigators:Wohleb, Eric 07-01-2019 -05-31-2021 National Institute of Mental Health Microglial brain-derived neurotrophic factor (BDNF) in stress and antidepressant responses Role:PI $200,625.00 Awarded Level:Federal

Grant: #R21DA049253 Investigators:Reyes, Teresa; Wohleb, Eric 09-01-2019 -08-31-2021 National Institute on Drug Abuse DAT18-09 Maternal opioid exposure and executive function evaluation in the mouse Role:Collaborator $240,750.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Horchar, Matthew J; Wohleb, Eric S (2019. )Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress.Brain, Behavior, and Immunity, ,

Wohleb, Eric S; Terwilliger, Rosemarie; Duman, Catharine H; Duman, Ronald S (2018. )Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior.Biological Psychiatry, ,83 (1 ),38-49

Wohleb, Eric S; Wu, Min; Gerhard, Danielle M; Taylor, Seth R; Picciotto, Marina R; Alreja, Meenakshi; Duman, Ronald S (2016. )GABA interneurons mediate the rapid antidepressant-like effects of scopolamine.The Journal of Clinical Investigation, ,126 (7 ),2482-94

Wohleb, Eric S (2016. )Neuron-Microglia Interactions in Mental Health Disorders: "For Better, and For Worse".Frontiers in Immunology, ,7 ,544

Wohleb, Eric S; Franklin, Tina; Iwata, Masaaki; Duman, Ronald S (2016. )Integrating neuroimmune systems in the neurobiology of depression.Nature Reviews Neuroscience, ,17 (8 ),497-511

Wohleb, Eric S; McKim, Daniel B; Sheridan, John F; Godbout, Jonathan P (2014. )Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior.Frontiers in Neuroscience, ,8 ,447

Wohleb, Eric S; McKim, Daniel B; Shea, Daniel T; Powell, Nicole D; Tarr, Andrew J; Sheridan, John F; Godbout, Jonathan P (2014. )Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.Biological Psychiatry, ,75 (12 ),970-81

Wohleb, Eric S; Patterson, Jenna M; Sharma, Vikram; Quan, Ning; Godbout, Jonathan P; Sheridan, John F (2014. )Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior.The Journal of Neuroscience, ,34 (7 ),2583-91

Wohleb, Eric S; Powell, Nicole D; Godbout, Jonathan P; Sheridan, John F (2013. )Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior.The Journal of Neuroscience, ,33 (34 ),13820-33

Wohleb, Eric S; Fenn, Ashley M; Pacenta, Ann M; Powell, Nicole D; Sheridan, John F; Godbout, Jonathan P (2012. )Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.Psychoneuroendocrinology, ,37 (9 ),1491-505

Wohleb, Eric S; Hanke, Mark L; Corona, Angela W; Powell, Nicole D; Stiner, La (2011. )Beta-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat.The Journal of Neuroscience, ,31 (17 ),6277-88

Post Graduate Training and Education

10-2013-03-2015 Postdoctoral Research Associate, Yale University School of Medicine, ,New Haven, Connecticut, U.S.A.

04-2015-08-2016 Associate Research Scientist, Yale University School of Medicine, ,New Haven, Connecticut, U.S.A.

Contact Information

Academic - Reading Campus
2120 East Galbraith Road
CincinnatiĀ  Ohio, 45237
Phone: 513-558-6870
Fax: 513-297-0966
eric.wohleb@uc.edu