Roger T Worrell

Grant: #903099 Investigators:Amoakon, Adioumani; Worrell, Roger 01-01-2022 -12-31-2023 American Heart Association - National Chapter Mechanism of loss of small pulmonary blood vessels in Cystic Fibrosis Role:PI 32036.00 Hold Level:Non Profit

Peer Reviewed Publications

Shawki, Ali; Engevik, Melinda A; Kim, Robert S; Knight, Patrick B; Baik, Rusty A; Anthony, Sarah R; Worrell, Roger T; Shull, Gary E; Mackenzie, Bryan  (2016). Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse. American journal of physiology. Gastrointestinal and liver physiology, 311 (3) , G423-30More Information

Shawki, Ali; Anthony, Sarah R; Nose, Yasuhiro; Engevik, Melinda A; Niespodzany, Eric J; Barrientos, Tomasa; Öhrvik, Helena; Worrell, Roger T; Thiele, Dennis J; Mackenzie, Bryan  (2015). Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. American journal of physiology. Gastrointestinal and liver physiology, 309 (8) , G635-47More Information

Schumacher, Michael A; Aihara, Eitaro; Feng, Rui; Engevik, Amy; Shroyer, Noah F; Ottemann, Karen M; Worrell, Roger T; Montrose, Marshall H; Shivdasani, Ramesh A; Zavros, Yana  (2015). The use of murine-derived fundic organoids in studies of gastric physiology. The Journal of physiology, 593 (8) , 1809-27More Information

Engevik, Melinda A; Yacyshyn, Mary Beth; Engevik, Kristen A; Wang, Jiang; Darien, Benjamin; Hassett, Daniel J; Yacyshyn, Bruce R; Worrell, Roger T  (2015). Human Clostridium difficile infection: altered mucus production and composition. American journal of physiology. Gastrointestinal and liver physiology, 308 (6) , G510-24More Information

Engevik, Melinda A; Engevik, Kristen A; Yacyshyn, Mary Beth; Wang, Jiang; Hassett, Daniel J; Darien, Benjamin; Yacyshyn, Bruce R; Worrell, Roger T  (2015). Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile. American journal of physiology. Gastrointestinal and liver physiology, 308 (6) , G497-509More Information

Donnelly, Jessica M; Engevik, Amy C; Engevik, Melinda; Schumacher, Michael A; Xiao, Chang; Yang, Li; Worrell, Roger T; Zavros, Yana  (2014). Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell. Digestive diseases and sciences, 59 (3) , 569-82More Information

Engevik, Melinda A; Aihara, Eitaro; Montrose, Marshall H; Shull, Gary E; Hassett, Daniel J; Worrell, Roger T  (2013). Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth. American journal of physiology. Gastrointestinal and liver physiology, 305 (10) , G697-711More Information

Engevik, Melinda A; Hickerson, Annelies; Shull, Gary E; Worrell, Roger T  (2013). Acidic conditions in the NHE2(-/-) mouse intestine result in an altered mucosa-associated bacterial population with changes in mucus oligosaccharides. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 32 (7) , 111-28More Information

Engevik, Melinda A; Faletti, Carla J; Paulmichl, Markus; Worrell, Roger T  (2013). Prebiotic properties of galursan HF 7K on mouse gut microbiota. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 32 (7) , 96-110More Information

Mykoniatis, Andreas; Shen, Le; Fedor-Chaiken, Mary; Tang, Jun; Tang, Xu; Worrell, Roger T; Delpire, Eric; Turner, Jerrold R; Matlin, Karl S; Bouyer, Patrice; Matthews, Jeffrey B  (2010). Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. American journal of physiology. Cell physiology, 298 (1) , C85-97More Information

Guan, Yanfang; Worrell, Roger T; Pritts, Timothy A; Montrose, Marshall H  (2009). Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo. American journal of physiology. Gastrointestinal and liver physiology, 297 (1) , G187-96More Information

Worrell, Roger T; Merk, Lisa; Matthews, Jeffrey B  (2008). Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1. American journal of physiology. Gastrointestinal and liver physiology, 294 (2) , G429-40More Information

Ishiguro, Hiroshi; Namkung, Wan; Yamamoto, Akiko; Wang, Zhaohui; Worrell, Roger T; Xu, Jie; Lee, Min Goo; Soleimani, Manoocher  (2007). Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct. American journal of physiology. Gastrointestinal and liver physiology, 292 (1) , G447-55More Information

Schweinfest, Clifford W; Spyropoulos, Demetri D; Henderson, Kelly W; Kim, Jae-Ho; Chapman, Jeannie M; Barone, Sharon; Worrell, Roger T; Wang, Zhaohui; Soleimani, Manoocher  (2006). slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. The Journal of biological chemistry, 281 (49) , 37962-71More Information

Xu, Jie; Worrell, Roger T; Li, Hong C; Barone, Sharon L; Petrovic, Snezana; Amlal, Hassane; Soleimani, Manoocher  (2006). Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. Journal of the American Society of Nephrology : JASN, 17 (4) , 956-67More Information

Worrell, Roger T; Best, Alison; Crawford, Oscar R; Xu, Jie; Soleimani, Manoocher; Matthews, Jeffrey B  (2005). Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent. American journal of physiology. Gastrointestinal and liver physiology, 289 (4) , G768-78More Information

Li, Hong C; Szigligeti, Peter; Worrell, Roger T; Matthews, Jeffrey B; Conforti, Laura; Soleimani, Manoocher  (2005). Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis. American journal of physiology. Renal physiology, 289 (1) , F61-71More Information

Mammen, Joshua M V; Song, J Cecilia; Yoo, James; Kim, Peter S; Davis, Harold W; Calvo, M Isabel; Worrell, Roger T; Matlin, Karl S; Matthews, Jeffrey B  (2005). Differential subcellular targeting of PKC-epsilon in response to pharmacological or ischemic stimuli in intestinal epithelia. American journal of physiology. Gastrointestinal and liver physiology, 288 (1) , G135-42More Information

Li, Hong C; Worrell, Roger T; Matthews, Jeffrey B; Husseinzadeh, Holleh; Neumeier, Lisa; Petrovic, Snezana; Conforti, Laura; Soleimani, Manoocher  (2004). Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane. The Journal of biological chemistry, 279 (41) , 43190-7More Information

Tong, Qiusheng; Booth, Rachell E; Worrell, Roger T; Stockand, James D  (2004). Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades. American journal of physiology. Renal physiology, 286 (6) , F1232-8More Information

Worrell, Roger T; Matthews, Jeffrey B  (2004). Effects of ammonium on ion channels and transporters in colonic secretory cells. Advances in experimental medicine and biology, 559, 131-9

Worrell, Roger T; Oghene, Jennifer; Matthews, Jeffrey B  (2004). Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior. American journal of physiology. Gastrointestinal and liver physiology, 286 (1) , G14-22More Information

Yoo, James; Nichols, Anthony; Mammen, Joshua; Calvo, Isabel; Song, Jaekyung C; Worrell, Roger T; Matlin, Karl; Matthews, Jeffrey B  (2003). Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins. American journal of physiology. Cell physiology, 285 (2) , C300-9More Information

Yoo, James; Nichols, Anthony; Song, Jaekyung C; Mammen, Joshua; Calvo, Isabel; Worrell, Roger T; Cuppoletti, John; Matlin, Karl; Matthews, Jeffrey B  (2003). Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes. American journal of physiology. Gastrointestinal and liver physiology, 284 (4) , G703-12More Information

Fink, Aaron S; Wang, Yuanhong; Mendez, Tatiana; Worrell, Roger T; Eaton, Douglas; Nguyen, Toan D; Lee, Sum P  (2002). Angiotensin II evokes calcium-mediated signaling events in isolated dog pancreatic epithelial cells. Pancreas, 25 (3) , 290-5

Stockand, J D; Zeltwanger, S; Bao, H F; Becchetti, A; Worrell, R T; Eaton, D C  (2001). S-adenosyl-L-homocysteine hydrolase is necessary for aldosterone-induced activity of epithelial Na(+) channels. American journal of physiology. Cell physiology, 281 (3) , C773-85More Information

Worrell, R T; Bao, H F; Denson, D D; Eaton, D C  (2001). Contrasting effects of cPLA2 on epithelial Na+ transport. American journal of physiology. Cell physiology, 281 (1) , C147-56More Information

Denson, D D; Wang, X; Worrell, R T; AlKhalili, O; Eaton, D C  (2001). Cytosolic phospholipase A2 is required for optimal ATP activation of BK channels in GH(3) cells. The Journal of biological chemistry, 276 (10) , 7136-42More Information

Denson, D D; Wang, X; Worrell, R T; Eaton, D C  (2000). Effects of fatty acids on BK channels in GH(3) cells. American journal of physiology. Cell physiology, 279 (4) , C1211-9More Information

Stockand, J D; Spier, B J; Worrell, R T; Yue, G; Al-Baldawi, N; Eaton, D C  (1999). Regulation of Na(+) reabsorption by the aldosterone-induced small G protein K-Ras2A. The Journal of biological chemistry, 274 (50) , 35449-54

Stockand, J D; Al-Baldawi, N F; Al-Khalili, O K; Worrell, R T; Eaton, D C  (1999). S-adenosyl-L-homocysteine hydrolase regulates aldosterone-induced Na+ transport. The Journal of biological chemistry, 274 (6) , 3842-50

Denson, D D; Worrell, R T; Middleton, P; Eaton, D C  (1999). Ca2+ sensitivity of BK channels in GH3 cells involves cytosolic phospholipase A2. The American journal of physiology, 276 (1 Pt 1) , C201-9

Ling, B N; Zuckerman, J B; Lin, C; Harte, B J; McNulty, K A; Smith, P R; Gomez, L M; Worrell, R T; Eaton, D C; Kleyman, T R  (1997). Expression of the cystic fibrosis phenotype in a renal amphibian epithelial cell line. The Journal of biological chemistry, 272 (1) , 594-600

Denson, D D; Worrell, R T; Eaton, D C  (1996). A possible role for phospholipase A2 in the action of general anesthetics. The American journal of physiology, 270 (2 Pt 1) , C636-44More Information

Cunningham, S A; Worrell, R T; Benos, D J; Frizzell, R A  (1992). cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA. The American journal of physiology, 262 (3 Pt 1) , C783-8More Information

Drumm, M L; Wilkinson, D J; Smit, L S; Worrell, R T; Strong, T V; Frizzell, R A; Dawson, D C; Collins, F S  (1991). Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes. Science (New York, N.Y.), 254 (5039) , 1797-9

Worrell, R T; Frizzell, R A  (1991). CaMKII mediates stimulation of chloride conductance by calcium in T84 cells. The American journal of physiology, 260 (4 Pt 1) , C877-82More Information

Shoemaker, R L; Worrell, R T  (1991). Ca2(+)-sensitive K+ channel in aortic smooth muscle of rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 196 (3) , 325-32

Cliff, W H; Worrell, R T; Morris, A P; Frizzell, R A  (1991). Conductance pathways involved in chloride secretion and their regulation. Advances in experimental medicine and biology, 290, 197-206; discussion

Worrell, R T; Butt, A G; Cliff, W H; Frizzell, R A  (1989). A volume-sensitive chloride conductance in human colonic cell line T84. The American journal of physiology, 256 (6 Pt 1) , C1111-9More Information

Bridges, R J; Worrell, R T; Frizzell, R A; Benos, D J  (1989). Stilbene disulfonate blockade of colonic secretory Cl- channels in planar lipid bilayers. The American journal of physiology, 256 (4 Pt 1) , C902-12More Information