Roger Worrell

Roger T Worrell

Associate Professor Educator

Medical Sciences Building

4251

COM PSP Systems Physiology - 0576

Publications

Peer Reviewed Publications

Shawki, Ali; Engevik, Melinda A; Kim, Robert S; Knight, Patrick B; Baik, Rusty A; Anthony, Sarah R; Worrell, Roger T; Shull, Gary E; Mackenzie, Bryan (2016. ) Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse.American journal of physiology. Gastrointestinal and liver physiology, , 311 (3 ) ,G423-30 More Information

Shawki, Ali; Anthony, Sarah R; Nose, Yasuhiro; Engevik, Melinda A; Niespodzany, Eric J; Barrientos, Tomasa; Öhrvik, Helena; Worrell, Roger T; Thiele, Dennis J; Mackenzie, Bryan (2015. ) Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese.American journal of physiology. Gastrointestinal and liver physiology, , 309 (8 ) ,G635-47 More Information

Schumacher, Michael A; Aihara, Eitaro; Feng, Rui; Engevik, Amy; Shroyer, Noah F; Ottemann, Karen M; Worrell, Roger T; Montrose, Marshall H; Shivdasani, Ramesh A; Zavros, Yana (2015. ) The use of murine-derived fundic organoids in studies of gastric physiology.The Journal of physiology, , 593 (8 ) ,1809-27 More Information

Engevik, Melinda A; Yacyshyn, Mary Beth; Engevik, Kristen A; Wang, Jiang; Darien, Benjamin; Hassett, Daniel J; Yacyshyn, Bruce R; Worrell, Roger T (2015. ) Human Clostridium difficile infection: altered mucus production and composition.American journal of physiology. Gastrointestinal and liver physiology, , 308 (6 ) ,G510-24 More Information

Engevik, Melinda A; Engevik, Kristen A; Yacyshyn, Mary Beth; Wang, Jiang; Hassett, Daniel J; Darien, Benjamin; Yacyshyn, Bruce R; Worrell, Roger T (2015. ) Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile.American journal of physiology. Gastrointestinal and liver physiology, , 308 (6 ) ,G497-509 More Information

Donnelly, Jessica M; Engevik, Amy C; Engevik, Melinda; Schumacher, Michael A; Xiao, Chang; Yang, Li; Worrell, Roger T; Zavros, Yana (2014. ) Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell.Digestive diseases and sciences, , 59 (3 ) ,569-82 More Information

Engevik, Melinda A; Aihara, Eitaro; Montrose, Marshall H; Shull, Gary E; Hassett, Daniel J; Worrell, Roger T (2013. ) Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth.American journal of physiology. Gastrointestinal and liver physiology, , 305 (10 ) ,G697-711 More Information

Engevik, Melinda A; Hickerson, Annelies; Shull, Gary E; Worrell, Roger T (2013. ) Acidic conditions in the NHE2(-/-) mouse intestine result in an altered mucosa-associated bacterial population with changes in mucus oligosaccharides.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 32 (7 ) ,111-28 More Information

Engevik, Melinda A; Faletti, Carla J; Paulmichl, Markus; Worrell, Roger T (2013. ) Prebiotic properties of galursan HF 7K on mouse gut microbiota.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 32 (7 ) ,96-110 More Information

Mykoniatis, Andreas; Shen, Le; Fedor-Chaiken, Mary; Tang, Jun; Tang, Xu; Worrell, Roger T; Delpire, Eric; Turner, Jerrold R; Matlin, Karl S; Bouyer, Patrice; Matthews, Jeffrey B (2010. ) Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway.American journal of physiology. Cell physiology, , 298 (1 ) ,C85-97 More Information

Guan, Yanfang; Worrell, Roger T; Pritts, Timothy A; Montrose, Marshall H (2009. ) Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo.American journal of physiology. Gastrointestinal and liver physiology, , 297 (1 ) ,G187-96 More Information

Worrell, Roger T; Merk, Lisa; Matthews, Jeffrey B (2008. ) Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1.American journal of physiology. Gastrointestinal and liver physiology, , 294 (2 ) ,G429-40 More Information

Ishiguro, Hiroshi; Namkung, Wan; Yamamoto, Akiko; Wang, Zhaohui; Worrell, Roger T; Xu, Jie; Lee, Min Goo; Soleimani, Manoocher (2007. ) Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct.American journal of physiology. Gastrointestinal and liver physiology, , 292 (1 ) ,G447-55 More Information

Schweinfest, Clifford W; Spyropoulos, Demetri D; Henderson, Kelly W; Kim, Jae-Ho; Chapman, Jeannie M; Barone, Sharon; Worrell, Roger T; Wang, Zhaohui; Soleimani, Manoocher (2006. ) slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon.The Journal of biological chemistry, , 281 (49 ) ,37962-71 More Information

Xu, Jie; Worrell, Roger T; Li, Hong C; Barone, Sharon L; Petrovic, Snezana; Amlal, Hassane; Soleimani, Manoocher (2006. ) Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion.Journal of the American Society of Nephrology : JASN, , 17 (4 ) ,956-67 More Information

Worrell, Roger T; Best, Alison; Crawford, Oscar R; Xu, Jie; Soleimani, Manoocher; Matthews, Jeffrey B (2005. ) Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent.American journal of physiology. Gastrointestinal and liver physiology, , 289 (4 ) ,G768-78 More Information

Li, Hong C; Szigligeti, Peter; Worrell, Roger T; Matthews, Jeffrey B; Conforti, Laura; Soleimani, Manoocher (2005. ) Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis.American journal of physiology. Renal physiology, , 289 (1 ) ,F61-71 More Information

Mammen, Joshua M V; Song, J Cecilia; Yoo, James; Kim, Peter S; Davis, Harold W; Calvo, M Isabel; Worrell, Roger T; Matlin, Karl S; Matthews, Jeffrey B (2005. ) Differential subcellular targeting of PKC-epsilon in response to pharmacological or ischemic stimuli in intestinal epithelia.American journal of physiology. Gastrointestinal and liver physiology, , 288 (1 ) ,G135-42 More Information

Li, Hong C; Worrell, Roger T; Matthews, Jeffrey B; Husseinzadeh, Holleh; Neumeier, Lisa; Petrovic, Snezana; Conforti, Laura; Soleimani, Manoocher (2004. ) Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane.The Journal of biological chemistry, , 279 (41 ) ,43190-7 More Information

Tong, Qiusheng; Booth, Rachell E; Worrell, Roger T; Stockand, James D (2004. ) Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades.American journal of physiology. Renal physiology, , 286 (6 ) ,F1232-8 More Information

Worrell, Roger T; Matthews, Jeffrey B (2004. ) Effects of ammonium on ion channels and transporters in colonic secretory cells. Advances in experimental medicine and biology, , 559 ,131-9

Worrell, Roger T; Oghene, Jennifer; Matthews, Jeffrey B (2004. ) Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior.American journal of physiology. Gastrointestinal and liver physiology, , 286 (1 ) ,G14-22 More Information

Yoo, James; Nichols, Anthony; Mammen, Joshua; Calvo, Isabel; Song, Jaekyung C; Worrell, Roger T; Matlin, Karl; Matthews, Jeffrey B (2003. ) Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins.American journal of physiology. Cell physiology, , 285 (2 ) ,C300-9 More Information

Yoo, James; Nichols, Anthony; Song, Jaekyung C; Mammen, Joshua; Calvo, Isabel; Worrell, Roger T; Cuppoletti, John; Matlin, Karl; Matthews, Jeffrey B (2003. ) Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes.American journal of physiology. Gastrointestinal and liver physiology, , 284 (4 ) ,G703-12 More Information

Fink, Aaron S; Wang, Yuanhong; Mendez, Tatiana; Worrell, Roger T; Eaton, Douglas; Nguyen, Toan D; Lee, Sum P (2002. ) Angiotensin II evokes calcium-mediated signaling events in isolated dog pancreatic epithelial cells. Pancreas, , 25 (3 ) ,290-5

Stockand, J D; Zeltwanger, S; Bao, H F; Becchetti, A; Worrell, R T; Eaton, D C (2001. ) S-adenosyl-L-homocysteine hydrolase is necessary for aldosterone-induced activity of epithelial Na(+) channels.American journal of physiology. Cell physiology, , 281 (3 ) ,C773-85 More Information

Worrell, R T; Bao, H F; Denson, D D; Eaton, D C (2001. ) Contrasting effects of cPLA2 on epithelial Na+ transport.American journal of physiology. Cell physiology, , 281 (1 ) ,C147-56 More Information

Denson, D D; Wang, X; Worrell, R T; AlKhalili, O; Eaton, D C (2001. ) Cytosolic phospholipase A2 is required for optimal ATP activation of BK channels in GH(3) cells.The Journal of biological chemistry, , 276 (10 ) ,7136-42 More Information

Denson, D D; Wang, X; Worrell, R T; Eaton, D C (2000. ) Effects of fatty acids on BK channels in GH(3) cells.American journal of physiology. Cell physiology, , 279 (4 ) ,C1211-9 More Information

Stockand, J D; Spier, B J; Worrell, R T; Yue, G; Al-Baldawi, N; Eaton, D C (1999. ) Regulation of Na(+) reabsorption by the aldosterone-induced small G protein K-Ras2A. The Journal of biological chemistry, , 274 (50 ) ,35449-54

Stockand, J D; Al-Baldawi, N F; Al-Khalili, O K; Worrell, R T; Eaton, D C (1999. ) S-adenosyl-L-homocysteine hydrolase regulates aldosterone-induced Na+ transport. The Journal of biological chemistry, , 274 (6 ) ,3842-50

Denson, D D; Worrell, R T; Middleton, P; Eaton, D C (1999. ) Ca2+ sensitivity of BK channels in GH3 cells involves cytosolic phospholipase A2. The American journal of physiology, , 276 (1 Pt 1 ) ,C201-9

Ling, B N; Zuckerman, J B; Lin, C; Harte, B J; McNulty, K A; Smith, P R; Gomez, L M; Worrell, R T; Eaton, D C; Kleyman, T R (1997. ) Expression of the cystic fibrosis phenotype in a renal amphibian epithelial cell line. The Journal of biological chemistry, , 272 (1 ) ,594-600

Denson, D D; Worrell, R T; Eaton, D C (1996. ) A possible role for phospholipase A2 in the action of general anesthetics.The American journal of physiology, , 270 (2 Pt 1 ) ,C636-44 More Information

Cunningham, S A; Worrell, R T; Benos, D J; Frizzell, R A (1992. ) cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA.The American journal of physiology, , 262 (3 Pt 1 ) ,C783-8 More Information

Drumm, M L; Wilkinson, D J; Smit, L S; Worrell, R T; Strong, T V; Frizzell, R A; Dawson, D C; Collins, F S (1991. ) Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes. Science (New York, N.Y.), , 254 (5039 ) ,1797-9

Worrell, R T; Frizzell, R A (1991. ) CaMKII mediates stimulation of chloride conductance by calcium in T84 cells.The American journal of physiology, , 260 (4 Pt 1 ) ,C877-82 More Information

Shoemaker, R L; Worrell, R T (1991. ) Ca2(+)-sensitive K+ channel in aortic smooth muscle of rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), , 196 (3 ) ,325-32

Cliff, W H; Worrell, R T; Morris, A P; Frizzell, R A (1991. ) Conductance pathways involved in chloride secretion and their regulation. Advances in experimental medicine and biology, , 290 ,197-206; discussion

Worrell, R T; Butt, A G; Cliff, W H; Frizzell, R A (1989. ) A volume-sensitive chloride conductance in human colonic cell line T84.The American journal of physiology, , 256 (6 Pt 1 ) ,C1111-9 More Information

Bridges, R J; Worrell, R T; Frizzell, R A; Benos, D J (1989. ) Stilbene disulfonate blockade of colonic secretory Cl- channels in planar lipid bilayers.The American journal of physiology, , 256 (4 Pt 1 ) ,C902-12 More Information