Marlena Wosiski-Kuhn, MD, PhD

Bachelors Degree: Johns Hopkins University Baltimore, MD, (Neuroscience)

Graduate Degree: Wake Forest University Winston-Salem, NC, (Biomedical Research)

Medical Degree: Wake Forest University Winston-Salem, NC,

Grant: #EMF/EMRA Resident Research Grant Investigators:Wosiski-Kuhn, Marlena 07-01-2023 -06-30-2024 Emergency Medicine Foundation Central Nervous System Interleukin-6 (IL6) and Soluble IL6 Receptor in a Porcine Model of Traumatic Brain Injury Role:PI 6050.00 Hold Level:Non Profit

Peer Reviewed Publications

Milligan, Carol; Atassi, Nazem; Babu, Suma; Barohn, Richard J; Caress, James B; Cudkowicz, Merit E; Evora, Armineuza; Hawkins, Gregory A; Wosiski-Kuhn, Marlena; Macklin, Eric A; Shefner, Jeremy M; Simmons, Zachary; Bowser, Robert P; Ladha, Shafeeq S  (2021). Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients. Muscle & nerveMore Information

Wosiski-Kuhn, Marlena; Caress, James B; Cartwright, Michael S; Hawkins, Gregory A; Milligan, Carol  (2021). Interleukin 6 (IL6) level is a biomarker for functional disease progression within IL6R358Ala variant groups in amyotrophic lateral sclerosis patients. Amyotrophic lateral sclerosis & frontotemporal degeneration, 22 (3-4) , 248-259More Information

Wosiski-Kuhn, Marlena; Robinson, Mac; Strupe, Jane; Arounleut, Phonepasong; Martin, Matthew; Caress, James; Cartwright, Michael; Bowser, Robert; Cudkowicz, Merit; Langefeld, Carl; Hawkins, Gregory A; Milligan, Carol  (2019). IL6 receptor358Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis. Neurology(R) neuroimmunology & neuroinflammation, 6 (6) , e631More Information

Pathak, Sapna; Caress, James B; Wosiski-Kuhn, Marlena; Milligan, Carol; Williams, Delaney; Cartwright, Michael S  (2019). A pilot study of neuromuscular ultrasound as a biomarker for amyotrophic lateral sclerosis. Muscle & nerve, 59 (2) , 181-186More Information

Wosiski-Kuhn, Marlena; Lyon, Miles S; Caress, James; Milligan, Carol  (2019). Inflammation, immunity, and amyotrophic lateral sclerosis: II. immune-modulating therapies. Muscle & nerve, 59 (1) , 23-33More Information

Lyon, Miles S; Wosiski-Kuhn, Marlena; Gillespie, Rachel; Caress, James; Milligan, Carol  (2019). Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology. Muscle & nerve, 59 (1) , 10-22More Information

Wosiski-Kuhn, Marlena; Bota, Mihail; Snider, Christina A; Wilson, Steven P; Venkataraju, Kannan U; Osten, Pavel; Stranahan, Alexis M  (2018). Hippocampal brain-derived neurotrophic factor determines recruitment of anatomically connected networks after stress in diabetic mice. Hippocampus, 28 (12) , 900-912More Information

Dey, Aditi; Hao, Shuai; Wosiski-Kuhn, Marlena; Stranahan, Alexis M  (2017). Glucocorticoid-mediated activation of GSK3? promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging, 57, 75-83More Information

McGee-Lawrence, Meghan E; Wenger, Karl H; Misra, Sudipta; Davis, Catherine L; Pollock, Norman K; Elsalanty, Mohammed; Ding, Kehong; Isales, Carlos M; Hamrick, Mark W; Wosiski-Kuhn, Marlena; Arounleut, Phonepasong; Mattson, Mark P; Cutler, Roy G; Yu, Jack C; Stranahan, Alexis M  (2017). Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice. Endocrinology, 158 (5) , 1160-1171More Information

Dey, Aditi; Hao, Shuai; Erion, Joanna R; Wosiski-Kuhn, Marlena; Stranahan, Alexis M  (2014). Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes. Journal of neuroimmunology, 269 (1-2) , 20-27More Information

Wosiski-Kuhn, Marlena; Erion, Joanna R; Gomez-Sanchez, Elise P; Gomez-Sanchez, Celso E; Stranahan, Alexis M  (2014). Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice. Psychoneuroendocrinology, 42, 165-77More Information

Erion, Joanna R; Wosiski-Kuhn, Marlena; Dey, Aditi; Hao, Shuai; Davis, Catherine L; Pollock, Norman K; Stranahan, Alexis M  (2014). Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 (7) , 2618-31More Information

Wosiski-Kuhn, Marlena; Stranahan, Alexis M  (2013). From pattern separation to mood regulation: multiple roles for developmental signals in the adult dentate gyrus. Frontiers in cellular neuroscience, 7, 96More Information

Stranahan, Alexis M; Erion, Joanna R; Wosiski-Kuhn, Marlena  (2013). Reelin signaling in development, maintenance, and plasticity of neural networks. Ageing research reviews, 12 (3) , 815-22More Information

Sherwood, Andrew; Wosiski-Kuhn, Marlena; Nguyen, Truc; Holland, Peter C; Lakaye, Bernard; Adamantidis, Antoine; Johnson, Alexander W  (2012). The role of melanin-concentrating hormone in conditioned reward learning. The European journal of neuroscience, 36 (8) , 3126-33More Information

Wosiski-Kuhn, Marlena; Stranahan, Alexis M  (2012). Opposing effects of positive and negative stress on hippocampal plasticity over the lifespan. Ageing research reviews, 11 (3) , 399-403More Information

Wosiski-Kuhn, Marlena; Stranahan, Alexis M  (2012). Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiation. Synapse (New York, N.Y.), 66 (7) , 661-4More Information

Johnson, A W; Sherwood, A; Smith, D R; Wosiski-Kuhn, M; Gallagher, M; Holland, P C  (2010). An analysis of licking microstructure in three strains of mice. Appetite, 54 (2) , 320-30More Information

Academic - University of Cincinnati College of Medicine
Department of Emergency Medicine
Cincinnati, OH  Ohio, 45267-0769
Phone: 513-558-8114
Fax: 513-558-5791
Marlena.Wosiski-Kuhn@uc.edu