Huixing Wu

Grant: #SRS 006131 Investigators:Wu, Huixing 10-01-2008 -07-31-2012 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Huixing Wu Role:PI $241,169.00 Closed Level:Federal

Grant: #VA IPA Wu Investigators:Wu, Huixing 10-01-2012 -07-31-2014 Department of Veterans Affairs Intergovernmental Personnel Act Agreement - Huixing Wu Role:PI $130,273.00 Active Level:Federal

Investigators:Wu, Huixing 05-01-2021 -04-30-2025 Department of Veterans Affairs VA IPA - Wu Role:PI 0.00 Hold Level:Federal

Grant: #VA IPa extension for Wu Investigators:Wu, Huixing 04-01-2024 -04-30-2025 Department of Veterans Affairs VA IPA for Wu Role:PI 91603.20 Hold Level:Federal

Peer Reviewed Publications

Goh, Boon Chong; Wu, Huixing; Rynkiewicz, Michael J; Schulten, Klaus; Seaton, Barbara A; McCormack, Francis X  (2016). Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry, 55 (26) , 3692-701More Information

Gardner, Jason C; Wu, Huixing; Noel, John G; Ramser, Benjamin J; Pitstick, Lori; Saito, Atsushi; Nikolaidis, Nikolaos M; McCormack, Francis X  (2016). Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function. American journal of physiology. Lung cellular and molecular physiology, 310 (9) , L868-79More Information

Wu, Huixing; Suzuki, Takuji; Carey, Brenna; Trapnell, Bruce C; McCormack, Francis X  (2011). Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages. The Journal of biological chemistry, 286 (17) , 14932-40More Information

Shang, Feifei; Rynkiewicz, Michael J; McCormack, Francis X; Wu, Huixing; Cafarella, Tanya M; Head, James F; Seaton, Barbara A  (2011). Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change. The Journal of biological chemistry, 286 (1) , 757-65More Information

Kuzmenko, Alexander I; Wu, Huixing; McCormack, Francis X  (2006). Pulmonary collectins selectively permeabilize model bacterial membranes containing rough lipopolysaccharide. Biochemistry, 45 (8) , 2679-85More Information

Ryan, Marnie A; Akinbi, Henry T; Serrano, Alicia G; Perez-Gil, Jesus; Wu, Huixing; McCormack, Francis X; Weaver, Timothy E  (2006). Antimicrobial activity of native and synthetic surfactant protein B peptides. Journal of immunology (Baltimore, Md. : 1950), 176 (1) , 416-25

Kuzmenko, Alexander I; Wu, Huixing; Wan, Sijue; McCormack, Francis X  (2005). Surfactant protein A is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid. The Journal of biological chemistry, 280 (27) , 25913-9More Information

Schaeffer, Lyndsay M; McCormack, Francis X; Wu, Huixing; Weiss, Alison A  (2004). Interactions of pulmonary collectins with Bordetella bronchiseptica and Bordetella pertussis lipopolysaccharide elucidate the structural basis of their antimicrobial activities. Infection and immunity, 72 (12) , 7124-30More Information

Schaeffer, Lyndsay M; McCormack, Francis X; Wu, Huixing; Weiss, Alison A  (2004). Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A. Journal of immunology (Baltimore, Md. : 1950), 173 (3) , 1959-65

McCormack, Francis X; Gibbons, Reta; Ward, Susan R; Kuzmenko, Alexander; Wu, Huixing; Deepe, George S  (2003). Macrophage-independent fungicidal action of the pulmonary collectins. The Journal of biological chemistry, 278 (38) , 36250-6More Information

Wu, Huixing; Kuzmenko, Alexander; Wan, Sijue; Schaffer, Lyndsay; Weiss, Alison; Fisher, James H; Kim, Kwang Sik; McCormack, Francis X  (2003). Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. The Journal of clinical investigation, 111 (10) , 1589-602More Information

Palaniyar, Nades; Zhang, Liquian; Kuzmenko, Alexander; Ikegami, Machiko; Wan, Sijue; Wu, Huixing; Korfhagen, Thomas R; Whitsett, Jeffrey A; McCormack, Francis X  (2002). The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo. The Journal of biological chemistry, 277 (30) , 26971-9More Information