Ying Xia

Ying Xia

Professor

Kettering Lab Complex

410

COM EH EGMT Xia Lab - 0056

PHD
160 Panzeca Way
Cincinnati, Ohio 45267-0056

Professional Summary

~~Signal transduction, morphogenesis, gene-environment interaction, in utero chemical exposure, fetal development, birth defect
Extracellular signals generated by diverse stimuli, such as growth factors and environmental chemicals, trigger a cascade of events from the cell membrane to the nucleus. Our lab is interested in understanding how these signals are coordinated and integrated to evoke a distinct cellular response such as growth, proliferation, differentiation or death. We focus on the interplay of a variety of signaling pathways to understand the regulation of cellular signals and biological outcomes.
Our current research is focused on the MAP3K1 signaling pathway. MAP3K1 is a protein kinase that regulates cascades of signaling events in response to the growth and morphogenetic factors. This signaling pathway is critical for eyelid morphogenesis in fetal development. Our research objective is to determine how the MAP3K1 pathway integrates diverse growth and stress signals and regulates tissue development in the biological systems. Since MAP3K1 regulates the most fundamental biological activity, i.e., epithelial cell migration, it can be implicated in a variety of migration-related processes, such as embryonic development, tumor metastasis and injury repair. We also aim to understand how deregulation of the MAP3K1 pathway through gene-gene and gene-environment interactions can lead to diseases, such as birth defect and cancer progression. Our research should provide insights into the migratory- and morphogenetic-regulatory mechanisms, identify causative agents, and lead to prevention and treatment of diseases.
MAP3K1 is a tissue- and stimuli-specific regulator of the MAP2K-MAPK signaling cascades. MAP3K1 is temporal-spatially expressed in developing embryo/fetus and adult tissues; its activity is induced by a wide variety of stimuli. Being a player in the network of physiological and environmental factor-elicited signaling pathways, MAP3K1 is responsible for activation of the JNK-c-Jun pathway, leading to gene expression, cytoskeleton organization, cell migration and eyelid morphogenesis. Our research goal is to understand the mechanisms of MAP3K1 signaling focusing on elucidating how MAP3K1 expression and activity is regulated and what are the ways through which MAP3K1 integrates multiple signals to regulate cell migration and morphogenesis. Our studies will address the roles of MAP3K1 in signal transduction and biological processes using a combination of genetic, biochemical, cellular and molecular biological techniques and investigate the mechanisms of gene-gene and gene-environment interaction in organisms’ homeostasis and diseases using genetic mouse models.
 

Education

BS, Wuhan University Wuhan, China, 1984 (Virology)

MS, National Institute of Vaccine and Serum Beijing, China, 1989 (Virology and Immunology)

PHD, UT Southwestern Medical Center Dallas, Texas, 1994 (Microbiology and Immunology)

Research and Practice Interests

The research focuses on establishing an understanding of the role of signal transduction pathways in cell responses to physiological and environmental agents. The ongoing work employs genetic, biochemical and molecular biological techniques to address fundamental questions regarding the function and regulatory mechanisms of signaling kinases in the areas of environmental toxicology, developmental biology, tissue regeneration, and cancer prevention and treatment.

Research Support

Grant: #R01-ES-011798 Investigators:Xia, Ying 09-30-2003 -07-31-2009 National Institute of Environmental Health Sciences Signaling Mechanisms of AHR Complex Activation by TCDD Role:PI $1,615,819.00 Closed Level:Federal

Grant: #R01 EY015227 Investigators:Xia, Ying 02-01-2004 -01-31-2010 National Eye Institute P Mechanisms of MEK Kinase 1 in mouse eyelid development Role:PI $1,692,043.00 Closed Level:Federal

Investigators:Xia, Ying 06-01-2002 -02-28-2006 Philip Morris External Research Program Role of MAP Kinesis in Lung Carcinogenicity of Benzo[a]pyrene Role:PI $876,160.00 Closed Level:Industry

Grant: #2003-UC-01-02-A0-S0-E0 Investigators:Xia, Ying 07-01-2002 -06-30-2004 Ohio Cancer Research Associates Role of MEKKI in Anti-cancer Treatment Role:PI $50,000.00 Closed Level:Private Non-Profit

Grant: #R01 EY013755 Investigators:Kao, Winston Whei Yang; Liu, Chia-Yang; Meij, Johanna T; Xia, Ying 12-01-2008 -11-30-2013 National Eye Institute Roles of Growth Factors on Corneal Morphogenesis Role:Collaborator $2,281,831.00 Active Level:Federal

Grant: #R01 EY015227 Investigators:Ho, Shuk Mei; Kao, Winston Whei Yang; Puga, Alvaro; Tam, Neville Ngai Chung; Xia, Ying 06-01-2009 -05-31-2014 National Eye Institute The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis Role:PI $1,759,938.00 Active Level:Federal

Grant: #F31 EY019458 Investigators:Geh, Esmond; Ho, Shuk Mei; Xia, Ying 03-01-2010 -02-28-2011 National Eye Institute Molecular Regulation of MAP3 Kinase1 in Ocular Morphogenesis Role:Collaborator $41,176.00 Closed Level:Federal

Grant: #R01 ES010807 Investigators:Nebert, Daniel; Puga, Alvaro; Xia, Ying 01-06-2011 -12-31-2015 National Institute of Environmental Health Sciences Molecular Mechanisms of Complex Mixture Toxicity Role:Collaborator $1,347,002.00 Active Level:Federal

Grant: #R21ES023507 Investigators:Xia, Ying 07-01-2014 -06-30-2016 National Institute of Environmental Health Sciences Gene-Environment Interactions in Eyelid Morphogenesis Role:PI $237,750.00 Awarded Level:Federal

Grant: #R01 EY015227-10A1 Investigators:Kao, Winston Whei Yang; Puga, Alvaro; Xia, Ying 12-01-2014 -11-30-2019 National Eye Institute The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis Role:PI $395,729.00 Active Level:Federal

Grant: #R01EY011845 Investigators:Call, Mindy; Kao, Winston Whei Yang; Xia, Ying 09-01-2014 -06-30-2018 National Eye Institute Structure/Function Relationship of the Lumican Gene Role:Collaborator $546,015.00 Awarded Level:Federal

Grant: #ES010807 Investigators:Biesiada, Jacek; Medvedovic, Mario; Niu, Liang; Puga, Alvaro; Xia, Ying 09-30-2017 -06-30-2022 National Institute of Environmental Health Sciences Molecular Mechanisms of Complex Mixture Toxicity Role:Collaborator $445,504.00 Awarded Level:Federal

Grant: #R01HD098106 Investigators:Medvedovic, Mario; Puga, Alvaro; Xia, Ying 04-09-2019 -03-31-2024 National Institute of Child Health and Human Development Gene-environment interactions in epithelial morphogenesis Role:PI $463,850.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Meng, Qinghang; Mongan, Maureen; Carreira, Vinicius; Kurita, Hisaka; Liu, Chia-Yang; Kao, Winston; Xia, Ying (2014. ) Eyelid closure in embryogenesis is required for ocular adnexa development.Investigative ophthalmology & visual science, ,

Meng, Qinghang; Mongan, Maureen; Wang, Jingjing; Tang, Xiaofang; Zhang, Jinling; Kao, Winston; Xia, Ying (2014. ) Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.Developmental biology, , 395 (1 ) ,29-37

Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro (2014. ) The Ah Receptor Recruits IKK? to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation.Toxicological sciences : an official journal of the Society of Toxicology, , 139 (1 ) ,121-32

Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro (2014. ) Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene.Toxicology, , 316 ,14-24

Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro (2014. ) Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure.PloS one, , 9 (5 ) ,e97849

Meng, Qinghang; Jin, Chang; Chen, Yinglei; Chen, Jing; Medvedovic, Mario; Xia, Ying (2014. ) Expression of signaling components in embryonic eyelid epithelium.PloS one, , 9 (2 ) ,e87038

Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro (2014. ) Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells.Stem cell research, , 12 (1 ) ,296-308

Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; Medvedovic, Mario; Puga, Alvaro Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis.Environmental health perspectives, , 121 (11-12 ) ,1334-43

Jin, Chang; Chen, Jing; Meng, Qinghang; Carreira, Vinicius; Tam, Neville N C; Geh, Esmond; Karyala, Saikumar; Ho, Shuk-Mei; Zhou, Xiangtian; Medvedovic, Mario; Xia, Ying (2013. ) Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.Developmental biology, , 374 (1 ) ,96-107

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro (2013. ) Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells.PloS one, , 8 (11 ) ,e80558

Wang, Jingcai; Xia, Ying (2012. ) Assessing developmental roles of MKK4 and MKK7 in vitro.Communicative & integrative biology, , 5 (4 ) ,319-24

Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying (2012. ) Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.The Journal of biological chemistry, , 287 (4 ) ,2787-97

Meng, Qinghang; Xia, Ying (2011. ) c-Jun, at the crossroad of the signaling network.Protein & cell, , 2 (11 ) ,889-98

Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying (2011. ) Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure.Proceedings of the National Academy of Sciences of the United States of America, , 108 (42 ) ,17349-54

Mongan, Maureen; Wang, Jingcai; Liu, Hongshan; Fan, Yunxia; Jin, Chang; Kao, Winston Y-W; Xia, Ying (2011. ) Loss of MAP3K1 enhances proliferation and apoptosis during retinal development.Development (Cambridge, England), , 138 (18 ) ,4001-12

Warr, Nick; Bogani, Debora; Siggers, Pam; Brixey, Rachel; Tateossian, Hilda; Dopplapudi, Asha; Wells, Sara; Cheeseman, Michael; Xia, Ying; Ostrer, Harry; Greenfield, Andy (2011. ) Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.PloS one, , 6 (5 ) ,e19572

Deng, Maoxian; Ding, Wei; Min, Xuewen; Xia, Ying (2011. ) MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells.Cytoskeleton (Hoboken, N.J.), , 68 (3 ) ,139-49

Chen, Liang; Meng, Qinghang; Kao, Winston; Xia, Ying (2011. ) I?B kinase ? regulates epithelium migration during corneal wound healing.PloS one, , 6 (1 ) ,e16132

Meng, Qinghang; Peng, Zhimin; Chen, Liang; Si, Jutong; Dong, Zhongyun; Xia, Ying (2010. ) Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells.Cancer letters, , 299 (1 ) ,45-53

Zhu, Yu-Jia; Xia, Ying; Ren, Guan-Jun; Wang, Meng-Zhao; Zeng, Xuan; Zhang, Li (2010. ) Efficacy and clinical/molecular predictors of erlotinib monotherapy for Chinese advanced non-small cell lung cancer. Chinese medical journal, , 123 (22 ) ,3200-5

Peng, Zhimin; Geh, Esmond; Chen, Liang; Meng, Qinghang; Fan, Yunxia; Sartor, Maureen; Shertzer, Howard G; Liu, Zheng-Gang; Puga, Alvaro; Xia, Ying (2010. ) Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione.Molecular pharmacology, , 77 (5 ) ,784-92

Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro (2010. ) The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.Cancer research, , 70 (1 ) ,212-20

Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying (2009. ) Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation.Environmental health perspectives, , 117 (7 ) ,1124-30

Malthankar-Phatak, Gauri H; Patel, Anant B; Xia, Ying; Hong, Soonsun; Chowdhury, Golam M I; Behar, Kevin L; Orina, Isaac A; Lai, James C K (2008. ) Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons.Brain research, , 1229 ,147-54

Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, Alvaro (2008. ) The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.Molecular biology of the cell, , 19 (8 ) ,3263-71

Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, George; Xia, Ying (2008. ) Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury.Toxicological sciences : an official journal of the Society of Toxicology, , 104 (2 ) ,405-11

Takatori, Atsushi; Geh, Esmond; Chen, Liang; Zhang, Lin; Meller, Jarek; Xia, Ying (2008. ) Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2.Development (Cambridge, England), , 135 (1 ) ,23-32

Kao, Winston W-Y; Xia, Ying; Liu, Chia-Yang; Saika, Shizuya (2008. ) Signaling pathways in morphogenesis of cornea and eyelid. The ocular surface, , 6 (1 ) ,9-23

Peng, Zhimin; Peng, Li; Fan, Yunxia; Zandi, Ebrahim; Shertzer, Howard G; Xia, Ying (2007. ) A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity.The Journal of biological chemistry, , 282 (29 ) ,21487-96

Deng, Maoxian; Chen, Wei-Li; Takatori, Atsushi; Peng, Zhimin; Zhang, Lin; Mongan, Maureen; Parthasarathy, Ranjani; Sartor, Maureen; Miller, Marian; Yang, Jianhua; Su, Bing; Kao, Winston W-Y; Xia, Ying (2006. ) A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.Molecular biology of the cell, , 17 (8 ) ,3446-55

Kao, Winston W-Y; Funderburgh, James L; Xia, Ying; Liu, Chia-Yang; Conrad, Gary W (2006. ) Focus on molecules: lumican.Experimental eye research, , 82 (1 ) ,3-4

Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro (2005. ) Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.Toxicological sciences : an official journal of the Society of Toxicology, , 87 (2 ) ,365-84

Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro (2005. ) Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes.Molecular pharmacology, , 68 (2 ) ,336-46

Puga, Alvaro; Tomlinson, Craig R; Xia, Ying (2005. ) Ah receptor signals cross-talk with multiple developmental pathways.Biochemical pharmacology, , 69 (2 ) ,199-207

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying (2005. ) MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.Molecular and cellular biology, , 25 (1 ) ,60-5

Tan, Zongqing; Huang, Mingya; Puga, Alvaro; Xia, Ying (2004. ) A critical role for MAP kinases in the control of Ah receptor complex activity.Toxicological sciences : an official journal of the Society of Toxicology, , 82 (1 ) ,80-7

Gao, Min; Labuda, Tord; Xia, Ying; Gallagher, Ewen; Fang, Deyu; Liu, Yun-Cai; Karin, Michael (2004. ) Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.Science (New York, N.Y.), , 306 (5694 ) ,271-5

Xia, Ying; Kao, Winston W-Y (2004. ) The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype.Biochemical pharmacology, , 68 (6 ) ,997-1001

Zhang, Lu; Lou, Danwen; Jiao, Hongyuan; Zhang, Dongsheng; Wang, Xinkang; Xia, Ying; Zhang, Jianhua; Xu, Ming (2004. ) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 24 (13 ) ,3344-54

Xia, Ying; Karin, Michael (2004. ) The control of cell motility and epithelial morphogenesis by Jun kinases.Trends in cell biology, , 14 (2 ) ,94-101

Zhang, Lin; Deng, Maoxian; Kao, Candace W C; Kao, Winston W Y; Xia, Ying (2003. ) MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis. Molecular vision, , 9 ,584-93

Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D (2003. ) c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.The EMBO journal, , 22 (19 ) ,5079-89

Zhang, Lin; Wang, Wei; Hayashi, Yasuhito; Jester, James V; Birk, David E; Gao, Min; Liu, Chia-Yang; Kao, Winston W-Y; Karin, Michael; Xia, Ying (2003. ) A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.The EMBO journal, , 22 (17 ) ,4443-54

Khoo, Shih; Griffen, Steven C; Xia, Ying; Baer, Richard J; German, Michael S; Cobb, Melanie H (2003. ) Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.The Journal of biological chemistry, , 278 (35 ) ,32969-77

Puga, Alvaro; Xia, Ying; Elferink, Cornelis (2002. ) Role of the aryl hydrocarbon receptor in cell cycle regulation. Chemico-biological interactions, , 141 (1-2 ) ,117-30

Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying (2002. ) Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochemical pharmacology, , 64 (5-6 ) ,771-80

Roy, Sanjit K; Hu, Junbo; Meng, Qingjun; Xia, Ying; Shapiro, Paul S; Reddy, Sekhar P M; Platanias, Leonidas C; Lindner, Daniel J; Johnson, Peter F; Pritchard, Catrin; Pagés, Gilles; Pouyssegur, Jacques; Kalvakolanu, Dhananjaya V (2002. ) MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.Proceedings of the National Academy of Sciences of the United States of America, , 99 (12 ) ,7945-50

Yousaf, Rizwan; Meng, Qinghang; Hufnagel, Robert B; Xia, Ying; Puligilla, Chandrakala; Ahmed, Zubair M; Riazuddin, Saima (2015. ) MAP3K1 function is essential for cyto-architecture of mouse organ of Corti and survival of auditory hair cells.Disease models & mechanisms, ,

Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro (2015. ) Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes.Toxicological sciences : an official journal of the Society of Toxicology, , 147 (2 ) ,425-35

Mongan, Maureen; Meng, Qinghang; Wang, Jingjing; Kao, Winston W-Y; Puga, Alvaro; Xia, Ying (2015. ) Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis.The Journal of biological chemistry, , 290 (32 ) ,19770-9

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, Andrew; Xia, Ying; Puga, Alvaro (2015. ) Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice.Toxicological sciences : an official journal of the Society of Toxicology, , 146 (1 ) ,52-64

Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro (2016. ) Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells.Stem cells (Dayton, Ohio), , 34 (12 ) ,2825-2839

Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro (2015. ) Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult.PloS one, , 10 (11 ) ,e0142440

Chen, Liang; Peng, Zhimin; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Sartor, Maureen; Chen, Jing; Niu, Liang; Medvedovic, Mario; Kao, Winston; Xia, Ying (2016. ) Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop.Protein & cell, , 7 (5 ) ,338-50

Chen, Liang; Mongan, Maureen; Meng, Qinghang; Wang, Qin; Kao, Winston; Xia, Ying (2016. ) Corneal Wound Healing Requires IKB kinase ? Signaling in Keratocytes.PloS one, , 11 (3 ) ,e0151869

Post Graduate Training and Education

1995-2000 Post-doctoral fellow, Signal Transduction with Dr. Michael Karin in Department of Pharmacology, University of California, San Diego, , San Diego, Californina

Keywords

Environmental Health,Signal Transduction,Gene Regulation,Cytoskeleton Reorganization,Cell Migration

Contact Information

Research - PHD
160 Panzeca Way
Cincinnati  Ohio, 45267-0056
Phone: 513-558-0371
ying.xia@uc.edu