Ying Xia , PhD

~~Signal transduction, morphogenesis, gene-environment interaction, in utero chemical exposure, fetal development, birth defect
Extracellular signals generated by diverse stimuli, such as growth factors and environmental chemicals, trigger a cascade of events from the cell membrane to the nucleus. Our lab is interested in understanding how these signals are coordinated and integrated to evoke a distinct cellular response such as growth, proliferation, differentiation or death. We focus on the interplay of a variety of signaling pathways to understand the regulation of cellular signals and biological outcomes.
Our current research is focused on the MAP3K1 signaling pathway. MAP3K1 is a protein kinase that regulates cascades of signaling events in response to the growth and morphogenetic factors. This signaling pathway is critical for eyelid morphogenesis in fetal development. Our research objective is to determine how the MAP3K1 pathway integrates diverse growth and stress signals and regulates tissue development in the biological systems. Since MAP3K1 regulates the most fundamental biological activity, i.e., epithelial cell migration, it can be implicated in a variety of migration-related processes, such as embryonic development, tumor metastasis and injury repair. We also aim to understand how deregulation of the MAP3K1 pathway through gene-gene and gene-environment interactions can lead to diseases, such as birth defect and cancer progression. Our research should provide insights into the migratory- and morphogenetic-regulatory mechanisms, identify causative agents, and lead to prevention and treatment of diseases.
MAP3K1 is a tissue- and stimuli-specific regulator of the MAP2K-MAPK signaling cascades. MAP3K1 is temporal-spatially expressed in developing embryo/fetus and adult tissues; its activity is induced by a wide variety of stimuli. Being a player in the network of physiological and environmental factor-elicited signaling pathways, MAP3K1 is responsible for activation of the JNK-c-Jun pathway, leading to gene expression, cytoskeleton organization, cell migration and eyelid morphogenesis. Our research goal is to understand the mechanisms of MAP3K1 signaling focusing on elucidating how MAP3K1 expression and activity is regulated and what are the ways through which MAP3K1 integrates multiple signals to regulate cell migration and morphogenesis. Our studies will address the roles of MAP3K1 in signal transduction and biological processes using a combination of genetic, biochemical, cellular and molecular biological techniques and investigate the mechanisms of gene-gene and gene-environment interaction in organisms’ homeostasis and diseases using genetic mouse models.
 

Bachelor's Degree: Wuhan University Wuhan, China, 1984 (Virology)

Master's Degree: National Institute of Vaccine and Serum Beijing, China, 1989 (Virology and Immunology)

Doctoral Degree: UT Southwestern Medical Center Dallas, Texas, 1994 (Microbiology and Immunology)

Postdoctoral fellowhip: University of California, San Diego San Diego, CA, 2000 (Pharmacology)

The research focuses on establishing an understanding of the role of signal transduction pathways in cell responses to physiological and environmental agents. The ongoing work employs genetic, biochemical and molecular biological techniques to address fundamental questions regarding the function and regulatory mechanisms of signaling kinases in the areas of environmental toxicology, developmental biology, tissue regeneration, and cancer prevention and treatment.

Grant: #R01-ES-011798 Investigators:Xia, Ying 09-30-2003 -07-31-2009 National Institute of Environmental Health Sciences Signaling Mechanisms of AHR Complex Activation by TCDD Role:PI $1,615,819.00 Closed Level:Federal

Grant: #R01 EY015227 Investigators:Xia, Ying 02-01-2004 -01-31-2010 National Eye Institute P Mechanisms of MEK Kinase 1 in mouse eyelid development Role:PI $1,692,043.00 Closed Level:Federal

Investigators:Xia, Ying 06-01-2002 -02-28-2006 Philip Morris External Research Program Role of MAP Kinesis in Lung Carcinogenicity of Benzo[a]pyrene Role:PI $876,160.00 Closed Level:Industry

Grant: #2003-UC-01-02-A0-S0-E0 Investigators:Xia, Ying 07-01-2002 -06-30-2004 Ohio Cancer Research Associates Role of MEKKI in Anti-cancer Treatment Role:PI $50,000.00 Closed Level:Private Non-Profit

Grant: #R01 EY013755 Investigators:Kao, Winston Whei Yang; Liu, Chia-Yang; Meij, Johanna T; Xia, Ying 12-01-2008 -11-30-2013 National Eye Institute Roles of Growth Factors on Corneal Morphogenesis Role:Collaborator $2,281,831.00 Active Level:Federal

Grant: #R01 EY015227 Investigators:Ho, Shuk Mei; Kao, Winston Whei Yang; Puga, Alvaro; Tam, Neville Ngai Chung; Xia, Ying 06-01-2009 -05-31-2014 National Eye Institute The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis Role:PI $1,759,938.00 Active Level:Federal

Grant: #F31 EY019458 Investigators:Geh, Esmond; Ho, Shuk Mei; Xia, Ying 03-01-2010 -02-28-2011 National Eye Institute Molecular Regulation of MAP3 Kinase1 in Ocular Morphogenesis Role:Collaborator $41,176.00 Closed Level:Federal

Grant: #R01 ES010807 Investigators:Nebert, Daniel; Puga, Alvaro; Xia, Ying 01-06-2011 -12-31-2015 National Institute of Environmental Health Sciences Molecular Mechanisms of Complex Mixture Toxicity Role:Collaborator $1,347,002.00 Active Level:Federal

Grant: #R21ES023507 Investigators:Xia, Ying 07-01-2014 -06-30-2016 National Institute of Environmental Health Sciences Gene-Environment Interactions in Eyelid Morphogenesis Role:PI $237,750.00 Awarded Level:Federal

Grant: #R01 EY015227-10A1 Investigators:Kao, Winston Whei Yang; Puga, Alvaro; Xia, Ying 12-01-2014 -11-30-2019 National Eye Institute The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis Role:PI $395,729.00 Active Level:Federal

Grant: #R01EY011845 Investigators:Call, Mindy; Kao, Winston Whei Yang; Xia, Ying 09-01-2014 -06-30-2018 National Eye Institute Structure/Function Relationship of the Lumican Gene Role:Collaborator $546,015.00 Awarded Level:Federal

Grant: #ES010807 Investigators:Biesiada, Jacek; Medvedovic, Mario; Niu, Liang; Puga, Alvaro; Xia, Ying 09-30-2017 -06-30-2022 National Institute of Environmental Health Sciences Molecular Mechanisms of Complex Mixture Toxicity Role:Collaborator $445,504.00 Awarded Level:Federal

Grant: #R01HD098106 Investigators:Medvedovic, Mario; Puga, Alvaro; Xia, Ying 04-09-2019 -03-31-2024 National Institute of Child Health and Human Development Gene-environment interactions in epithelial morphogenesis Role:PI $463,850.00 Awarded Level:Federal

Grant: #R21ES033342 Investigators:Burns, Katherine; Medvedovic, Mario; Puga, Alvaro; Xia, Ying 04-01-2022 -03-31-2024 National Institute of Environmental Health Sciences Signaling mechanisms of gene-environment interactions in female reproductive Role:PI 243000.00 Awarded Level:Federal

Peer Reviewed Publications

Meng, Qinghang; Mongan, Maureen; Carreira, Vinicius; Kurita, Hisaka; Liu, Chia-Yang; Kao, Winston; Xia, Ying (2014. ) Eyelid closure in embryogenesis is required for ocular adnexa development.Investigative ophthalmology & visual science, , More Information

Meng, Qinghang; Mongan, Maureen; Wang, Jingjing; Tang, Xiaofang; Zhang, Jinling; Kao, Winston; Xia, Ying (2014. ) Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.Developmental biology, , 395 (1 ) ,29-37 More Information

Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro (2014. ) The Ah Receptor Recruits IKK? to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation.Toxicological sciences : an official journal of the Society of Toxicology, , 139 (1 ) ,121-32 More Information

Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro (2014. ) Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene.Toxicology, , 316 ,14-24 More Information

Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro (2014. ) Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure.PloS one, , 9 (5 ) ,e97849 More Information

Meng, Qinghang; Jin, Chang; Chen, Yinglei; Chen, Jing; Medvedovic, Mario; Xia, Ying (2014. ) Expression of signaling components in embryonic eyelid epithelium.PloS one, , 9 (2 ) ,e87038 More Information

Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro (2014. ) Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells.Stem cell research, , 12 (1 ) ,296-308 More Information

Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; Medvedovic, Mario; Puga, Alvaro Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis.Environmental health perspectives, , 121 (11-12 ) ,1334-43 More Information

Jin, Chang; Chen, Jing; Meng, Qinghang; Carreira, Vinicius; Tam, Neville N C; Geh, Esmond; Karyala, Saikumar; Ho, Shuk-Mei; Zhou, Xiangtian; Medvedovic, Mario; Xia, Ying (2013. ) Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.Developmental biology, , 374 (1 ) ,96-107 More Information

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro (2013. ) Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells.PloS one, , 8 (11 ) ,e80558 More Information

Wang, Jingcai; Xia, Ying (2012. ) Assessing developmental roles of MKK4 and MKK7 in vitro.Communicative & integrative biology, , 5 (4 ) ,319-24 More Information

Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying (2012. ) Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.The Journal of biological chemistry, , 287 (4 ) ,2787-97 More Information

Meng, Qinghang; Xia, Ying (2011. ) c-Jun, at the crossroad of the signaling network.Protein & cell, , 2 (11 ) ,889-98 More Information

Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying (2011. ) Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure.Proceedings of the National Academy of Sciences of the United States of America, , 108 (42 ) ,17349-54 More Information

Mongan, Maureen; Wang, Jingcai; Liu, Hongshan; Fan, Yunxia; Jin, Chang; Kao, Winston Y-W; Xia, Ying (2011. ) Loss of MAP3K1 enhances proliferation and apoptosis during retinal development.Development (Cambridge, England), , 138 (18 ) ,4001-12 More Information

Warr, Nick; Bogani, Debora; Siggers, Pam; Brixey, Rachel; Tateossian, Hilda; Dopplapudi, Asha; Wells, Sara; Cheeseman, Michael; Xia, Ying; Ostrer, Harry; Greenfield, Andy (2011. ) Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.PloS one, , 6 (5 ) ,e19572 More Information

Deng, Maoxian; Ding, Wei; Min, Xuewen; Xia, Ying (2011. ) MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells.Cytoskeleton (Hoboken, N.J.), , 68 (3 ) ,139-49 More Information

Chen, Liang; Meng, Qinghang; Kao, Winston; Xia, Ying (2011. ) I?B kinase ? regulates epithelium migration during corneal wound healing.PloS one, , 6 (1 ) ,e16132 More Information

Meng, Qinghang; Peng, Zhimin; Chen, Liang; Si, Jutong; Dong, Zhongyun; Xia, Ying (2010. ) Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells.Cancer letters, , 299 (1 ) ,45-53 More Information

Zhu, Yu-Jia; Xia, Ying; Ren, Guan-Jun; Wang, Meng-Zhao; Zeng, Xuan; Zhang, Li (2010. ) Efficacy and clinical/molecular predictors of erlotinib monotherapy for Chinese advanced non-small cell lung cancer. Chinese medical journal, , 123 (22 ) ,3200-5

Peng, Zhimin; Geh, Esmond; Chen, Liang; Meng, Qinghang; Fan, Yunxia; Sartor, Maureen; Shertzer, Howard G; Liu, Zheng-Gang; Puga, Alvaro; Xia, Ying (2010. ) Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione.Molecular pharmacology, , 77 (5 ) ,784-92 More Information

Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro (2010. ) The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.Cancer research, , 70 (1 ) ,212-20 More Information

Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying (2009. ) Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation.Environmental health perspectives, , 117 (7 ) ,1124-30 More Information

Malthankar-Phatak, Gauri H; Patel, Anant B; Xia, Ying; Hong, Soonsun; Chowdhury, Golam M I; Behar, Kevin L; Orina, Isaac A; Lai, James C K (2008. ) Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons.Brain research, , 1229 ,147-54 More Information

Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, Alvaro (2008. ) The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.Molecular biology of the cell, , 19 (8 ) ,3263-71 More Information

Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, George; Xia, Ying (2008. ) Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury.Toxicological sciences : an official journal of the Society of Toxicology, , 104 (2 ) ,405-11 More Information

Takatori, Atsushi; Geh, Esmond; Chen, Liang; Zhang, Lin; Meller, Jarek; Xia, Ying (2008. ) Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2.Development (Cambridge, England), , 135 (1 ) ,23-32 More Information

Kao, Winston W-Y; Xia, Ying; Liu, Chia-Yang; Saika, Shizuya (2008. ) Signaling pathways in morphogenesis of cornea and eyelid. The ocular surface, , 6 (1 ) ,9-23

Peng, Zhimin; Peng, Li; Fan, Yunxia; Zandi, Ebrahim; Shertzer, Howard G; Xia, Ying (2007. ) A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity.The Journal of biological chemistry, , 282 (29 ) ,21487-96 More Information

Deng, Maoxian; Chen, Wei-Li; Takatori, Atsushi; Peng, Zhimin; Zhang, Lin; Mongan, Maureen; Parthasarathy, Ranjani; Sartor, Maureen; Miller, Marian; Yang, Jianhua; Su, Bing; Kao, Winston W-Y; Xia, Ying (2006. ) A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.Molecular biology of the cell, , 17 (8 ) ,3446-55 More Information

Kao, Winston W-Y; Funderburgh, James L; Xia, Ying; Liu, Chia-Yang; Conrad, Gary W (2006. ) Focus on molecules: lumican.Experimental eye research, , 82 (1 ) ,3-4 More Information

Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro (2005. ) Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.Toxicological sciences : an official journal of the Society of Toxicology, , 87 (2 ) ,365-84 More Information

Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro (2005. ) Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes.Molecular pharmacology, , 68 (2 ) ,336-46 More Information

Puga, Alvaro; Tomlinson, Craig R; Xia, Ying (2005. ) Ah receptor signals cross-talk with multiple developmental pathways.Biochemical pharmacology, , 69 (2 ) ,199-207 More Information

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying (2005. ) MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.Molecular and cellular biology, , 25 (1 ) ,60-5 More Information

Tan, Zongqing; Huang, Mingya; Puga, Alvaro; Xia, Ying (2004. ) A critical role for MAP kinases in the control of Ah receptor complex activity.Toxicological sciences : an official journal of the Society of Toxicology, , 82 (1 ) ,80-7 More Information

Gao, Min; Labuda, Tord; Xia, Ying; Gallagher, Ewen; Fang, Deyu; Liu, Yun-Cai; Karin, Michael (2004. ) Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.Science (New York, N.Y.), , 306 (5694 ) ,271-5 More Information

Xia, Ying; Kao, Winston W-Y (2004. ) The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype.Biochemical pharmacology, , 68 (6 ) ,997-1001 More Information

Zhang, Lu; Lou, Danwen; Jiao, Hongyuan; Zhang, Dongsheng; Wang, Xinkang; Xia, Ying; Zhang, Jianhua; Xu, Ming (2004. ) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 24 (13 ) ,3344-54 More Information

Xia, Ying; Karin, Michael (2004. ) The control of cell motility and epithelial morphogenesis by Jun kinases.Trends in cell biology, , 14 (2 ) ,94-101 More Information

Zhang, Lin; Deng, Maoxian; Kao, Candace W C; Kao, Winston W Y; Xia, Ying (2003. ) MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis. Molecular vision, , 9 ,584-93

Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D (2003. ) c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.The EMBO journal, , 22 (19 ) ,5079-89 More Information

Zhang, Lin; Wang, Wei; Hayashi, Yasuhito; Jester, James V; Birk, David E; Gao, Min; Liu, Chia-Yang; Kao, Winston W-Y; Karin, Michael; Xia, Ying (2003. ) A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.The EMBO journal, , 22 (17 ) ,4443-54 More Information

Khoo, Shih; Griffen, Steven C; Xia, Ying; Baer, Richard J; German, Michael S; Cobb, Melanie H (2003. ) Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.The Journal of biological chemistry, , 278 (35 ) ,32969-77 More Information

Puga, Alvaro; Xia, Ying; Elferink, Cornelis (2002. ) Role of the aryl hydrocarbon receptor in cell cycle regulation. Chemico-biological interactions, , 141 (1-2 ) ,117-30

Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying (2002. ) Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochemical pharmacology, , 64 (5-6 ) ,771-80

Roy, Sanjit K; Hu, Junbo; Meng, Qingjun; Xia, Ying; Shapiro, Paul S; Reddy, Sekhar P M; Platanias, Leonidas C; Lindner, Daniel J; Johnson, Peter F; Pritchard, Catrin; Pagés, Gilles; Pouyssegur, Jacques; Kalvakolanu, Dhananjaya V (2002. ) MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.Proceedings of the National Academy of Sciences of the United States of America, , 99 (12 ) ,7945-50 More Information

Yousaf, Rizwan; Meng, Qinghang; Hufnagel, Robert B; Xia, Ying; Puligilla, Chandrakala; Ahmed, Zubair M; Riazuddin, Saima (2015. ) MAP3K1 function is essential for cyto-architecture of mouse organ of Corti and survival of auditory hair cells.Disease models & mechanisms, , More Information

Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro (2015. ) Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes.Toxicological sciences : an official journal of the Society of Toxicology, , 147 (2 ) ,425-35 More Information

Mongan, Maureen; Meng, Qinghang; Wang, Jingjing; Kao, Winston W-Y; Puga, Alvaro; Xia, Ying (2015. ) Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis.The Journal of biological chemistry, , 290 (32 ) ,19770-9 More Information

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, Andrew; Xia, Ying; Puga, Alvaro (2015. ) Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice.Toxicological sciences : an official journal of the Society of Toxicology, , 146 (1 ) ,52-64 More Information

Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro (2016. ) Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells.Stem cells (Dayton, Ohio), , 34 (12 ) ,2825-2839 More Information

Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro (2015. ) Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult.PloS one, , 10 (11 ) ,e0142440 More Information

Chen, Liang; Peng, Zhimin; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Sartor, Maureen; Chen, Jing; Niu, Liang; Medvedovic, Mario; Kao, Winston; Xia, Ying (2016. ) Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop.Protein & cell, , 7 (5 ) ,338-50 More Information

Chen, Liang; Mongan, Maureen; Meng, Qinghang; Wang, Qin; Kao, Winston; Xia, Ying (2016. ) Corneal Wound Healing Requires IKB kinase ? Signaling in Keratocytes.PloS one, , 11 (3 ) ,e0151869 More Information

Environmental Health,Signal Transduction,Gene Regulation,Cytoskeleton Reorganization,Cell Migration

Research - PHD
160 Panzeca Way
Cincinnati  Ohio, 45267-0056
Phone: 513-558-0371
ying.xia@uc.edu