Changchun Xie , PhD

Ph.D.: University of Guelph Canada, 2003 (Statistics)

M.S.: Dalhousie University Canada, 1999 (Statistics)

M.S.: Zhejiang University China, 1992 (Mathematical statistics)

B.S.: Hunan Normal University China, 1989 (Mathematics)

My research interests include
1) clinical trials,
2) statistical genetics: next generation sequencing, Genome-wide association study, NDA methylation, gene environmental interaction,
3) statistical methodology: survival  models, multiple testing, hierarchical generalized linear models, nonparametric methods, longitudinal data and multivariate statistical analysis.

2001 -2001 Biostatistician, • Developed a new statistical method for bioavailability and bioequivalence analysis • Updated SAS program for analysis of bioavailability and bioequivalence studies , Therapeutic Products Directorate, Health Products and Food Branch, Health Canada, Ottawa, Canada

2002 -2007 Senior Statistical Analyst/Programmer, • Developing new statistical methods for analyzing multicentre clinical trials • Analyzing and publishing the results of Clinical Trials • Combining two large multicentre international clinical trials • Developing/validating SAS/SAS macro programs for large data management and statistical analysis • Developed practical Output Delivery System (ODS) Techniques for systematically and automatically generating high quality DSMB reports • Developing genetic statistical methods and analyzing large genetic data , PHRI, Department of Medicine, McMaster University, Hamilton, Canada

2007 -2012 Senior Statistical Analyst, • Supervising biostatisticians and senior biostatisticians in clinical trials, genetic studies and epidemiology studies • Developing new statistical methods for analyzing multicentre clinical trials • Developing genetic statistical methods and analyzing large genetic data • Analyzing and publishing the results of clinical trials • Preparing DSMB • Organizing regular statistical seminars , PHRI, Department of Medicine, McMaster University, Hamilton, Canada

2009 -2012 Assistant Professor, • Teaching in the Health Research Methodology Graduate Program • Teaching in the Population Genomics Program • Supervising Master/PhD students , Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

2012 -2015 Assistant Professor(tenure-track), • Teaching biostatistics courses • Supervising Master/PhD students • Statistical consulting (Clinical trials, epidemiology and genetic studies) • Reviewing grant proposals • DSMB member for Clinical trials • UC IRB Committee member • Protocol Review and Monitoring Committee member in UC Cancer Institute and UC Health , Department of Environmental Health, University of Cincinnati, Cincinnati, USA

2015 -2018 Associate Professor, • Teaching biostatistics courses • Supervising Master/PhD students • Statistical consulting (Clinical trials, epidemiology and genetic studies) • Reviewing grant proposals • DSMB member for Clinical trials • UC IRB Committee member • Protocol Review and Monitoring Committee member in UC Cancer Institute and UC Health , Department of Environmental Health, University of Cincinnati, Cincinnati, USA

2018 - Professor, • Co-PI/Co-I for multiple grants • Teaching biostatistics courses • Supervising Master/PhD students • Statistical consulting (Clinical trials, epidemiology and genetic studies) • Reviewing grant proposals • DSMB member for Clinical trials • UC IRB Committee member • Protocol Review and Monitoring Committee member in UC Cancer Institute and UC Health , Department of Environmental Health, University of Cincinnati, Cincinnati, USA

Grant: #R21ES024717 Investigators:Bhattacharya, Amit; Haynes, Erin; Heineman, William; Papautsky, Ian; Wilsey, Philip; Xie, Changchun 03-01-2015 -02-28-2017 National Institute of Environmental Health Sciences Validation and Demonstration of Point-of-Care Sensor for Multi-Metal Exposure Assessment Role:Collaborator $197,708.00 Awarded Level:Federal

Grant: #R21NS093493-01 Investigators:Hao, Jiukuan; Xie, Changchun 06-01-2015 -05-31-2017 National Institute of Neurological Disorders and Stroke Application of Brain-Targeted Anti-inflammatory RNA Nanoparticle for Ischemic Stroke Therapy Role:Collaborator $205,506.00 Awarded Level:Federal

Grant: #R01DK105379 Investigators:Attari, Mehran; Salehi, Marzieh; Xie, Changchun 07-01-2015 -05-31-2020 National Inst of Diabetes and Digestive and Kidney Disease The weight-independent effects of bariatric surgeries on islet cell function Role:Collaborator $555,488.00 Awarded Level:Federal

Grant: #RC105513UC/U01ES026119 Investigators:Pinney, Susan; Xie, Changchun 09-30-2015 -06-30-2020 National Institute of Environmental Health Sciences Mammary carcinogenesis: pubertal and adult effects of high fat diet+oxybenzone Role:Collaborator $35,343.00 Awarded Level:Federal

Grant: #Harry J. Lloyd Charitable Trust 2015-17 Investigators:Abdelmalek, Zalfa; Xie, Changchun; Zhang, Yuhang 06-01-2015 -05-31-2017 Harry J. Lloyd Charitable Trust Reprogramming the Tumor Microenvironment to Treat Melanoma Role:Collaborator $200,000.00 Active Level:Private Non-Profit

Grant: #UM1DK095710 Investigators:Xie, Changchun 09-01-2016 -08-31-2021 National Inst of Diabetes and Digestive and Kidney Disease Continuation of Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS), Biostatistics Research Center Role:PI $1,066,072.00 Active Level:Federal

Grant: #136802 / R01 HL132344 Investigators:Xie, Changchun 04-01-2016 -03-31-2021 National Heart, Lung and Blood Institute Unraveling ancestry and environmental exposure interactions in childhood asthma Role:PI $26,569.00 Active Level:Federal

Grant: #ES028277 Investigators:Chen, Aimin; Dietrich, Kim; Xie, Changchun 09-30-2017 -06-30-2022 National Institute of Environmental Health Sciences Developmental neurotoxicity of organophosphate and novel brominated flame retardants in children Role:Collaborator $664,377.00 Awarded Level:Federal

Grant: #R01ES027855 Investigators:Pinney, Susan; Rubinstein, Jack; Wang, Hongsheng; Xie, Changchun 02-01-2018 -01-31-2023 National Institute of Environmental Health Sciences Endocrine Disruptors and Heart Health Role:Collaborator $429,032.00 Active Level:Federal

Grant: #R01ES029133 Investigators:Chen, Aimin; Pinney, Susan; Xie, Changchun 08-15-2018 -06-30-2021 National Institute of Environmental Health Sciences Longitudinal study of endocrine disrupting chemical exposure and the early hormonal milieu of girls around the time of thelarche Role:Collaborator $394,749.00 Active Level:Federal

Grant: #R24ES028527 Investigators:Leung, Yuet Kin; Pinney, Susan; Reichard, John; Xie, Changchun 09-30-2018 -06-30-2023 National Institute of Environmental Health Sciences Fernald Community Cohort: Research Resource for Environmental Epidemiology Role:Collaborator $399,875.00 Active Level:Federal

Grant: #R01AR077238 Investigators:Supp, Dorothy; Xie, Changchun; Zhang, Yuhang 02-04-2021 -11-30-2025 National Institute of Arthritis, Musculoskeletal and Skin Disease Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute Role:Collaborator $364,613.00 Awarded Level:Federal

Grant: #R01AR077238 Investigators:Supp, Dorothy; Xie, Changchun; Zhang, Yuhang 02-01-2021 -11-30-2025 National Institute of Arthritis, Musculoskeletal and Skin Disease Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute Role:Collaborator $364,613.00 Awarded Level:Federal

Grant: #R01 DC009435 Investigators:Farbos de Luzan, Charles; Gutmark, Ephraim; Khosla, Siddarth; Oren, Liran; Xie, Changchun 04-01-2021 -03-31-2026 National Institute on Deafness and Other Communication Disor The Relationship Between Vortices, Acoustics, and Vibration in Vocal Fold Asymmetries Role:Collaborator 632470.00 Hold Level:Federal

Grant: #580431 / R01ES028277 Investigators:Xie, Changchun 04-19-2021 -12-31-2021 National Institute of Environmental Health Sciences DEVELOPMENTAL NEUROTOXICITY OF ORGANOPHOSPHATE AND NOVEL BROMINATED FLAME RETARDANTS IN CHILDREN Role:PI 51303.00 Active Level:Federal

Grant: #R01CA249737 Investigators:Abdelmalek, Zalfa; Chaudhary, Rekha; Harris, Gregory; Xie, Changchun; Zhang, Yuhang 06-15-2021 -05-31-2026 National Cancer Institute Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape Role:Collaborator 375431.00 Awarded Level:Federal

Grant: #R21ES032112 Investigators:Pinney, Susan; Thomas, Michael; Xie, Changchun 07-18-2022 -06-30-2024 National Institute of Environmental Health Sciences Uranium Exposure and Infertility in Reproductive Partners in the Fernald Community Cohort Role:Collaborator 258577.00 Awarded Level:Federal

Peer Reviewed Publications

Chen, Yaolong; Yang, Kehu; Jing, Tao; Tian, Jinhui; Shen, Xiping; Xie, Changchun; Ma, Bin; Liu, Yali; Yao, Liang; Cao, Xiaoyuan (2014. ) Use of text messages to communicate clinical recommendations to health workers in rural China: a cluster-randomized trial.Bulletin of the World Health Organization, , 92 (7 ) ,474-81 More Information

Bailey, Swneke D; Xie, Changchun; Paré, Guillaume; Montpetit, Alexandre; Mohan, Viswanathan; Yusuf, Salim; Gerstein, Hertzel; Engert, James C; Anand, Sonia S (2014. ) Variation at the DPP4 locus influences apolipoprotein B levels in South Asians and exhibits heterogeneity in Europeans related to BMI.Diabetologia, , 57 (4 ) ,738-45 More Information

Xie, Changchun (2014. ) Relations among Three Parametric Multiple Testing Methods for Correlated Tests.Journal of statistical computation and simulation, , 84 (4 ) ,812-818 More Information

Zhou, Tao; Li, Xia; Tang, Zhe; Xie, Changchun; Tao, Lixin; Pan, Lei; Huo, Da; Sun, Fei; Luo, Yanxia; Wang, Wei; Yan, Aoshuang; Guo, Xiuhua (2014. ) Risk factors of CVD mortality among the elderly in Beijing, 1992 - 2009: an 18-year cohort study.International journal of environmental research and public health, , 11 (2 ) ,2193-208 More Information

Tang, Zhe; Zhou, Tao; Luo, Yanxia; Xie, Changchun; Huo, Da; Tao, Lixin; Pan, Lei; Sun, Fei; Zhu, Huiping; Yang, Xinghua; Wang, Wei; Yan, Aoshuang; Li, Xia; Guo, Xiuhua (2014. ) Risk factors for cerebrovascular disease mortality among the elderly in Beijing: a competing risk analysis.PloS one, , 9 (2 ) ,e87884 More Information

Kirsh, Elliana R; van Leer, Eva; Phero, Heidi J; Xie, Changchun; Khosla, Sid (2013. ) Factors associated with singers' perceptions of choral singing well-being.Journal of voice : official journal of the Voice Foundation, , 27 (6 ) ,786.e25-32 More Information

Anand, Sonia S; Meyre, David; Pare, Guillaume; Bailey, Swneke D; Xie, Changchun; Zhang, Xiaohe; Montpetit, Alexandre; Desai, Dipika; Bosch, Jackie; Mohan, Viswanathan; Diaz, Rafael; McQueen, Matthew J; Cordell, Heather J; Keavney, Bernard; Yusuf, Salim; Gaudet, Daniel; Gerstein, Hertzel; Engert, James C (2013. ) Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study.Diabetes care, , 36 (9 ) ,2836-42 More Information

Xie, Changchun; Chen, Ding-Geng (2013. ) Letter to the editor.Biometrical journal. Biometrische Zeitschrift, , 55 (2 ) ,264-5 More Information

Yamanaka, Osamu; Yuan, Yong; Coulson-Thomas, Vivien Jane; Gesteira, Tarsis Ferreira; Call, Mindy K; Zhang, Yujin; Zhang, Jianhua; Chang, Shao-Hsuan; Xie, Changchun; Liu, Chia-Yang; Saika, Shizuya; Jester, James V; Kao, Winston W-Y (2013. ) Lumican binds ALK5 to promote epithelium wound healing.PloS one, , 8 (12 ) ,e82730 More Information

Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, A Darlene; Miller, Ruby; Lanktree, Matthew B; Saleheen, Danish; Danesh, John; Yusuf, Salim; Engert, James C; Hegele, Robert A; Anand, Sonia S (2012. ) BRCA2 variants and cardiovascular disease in a multi-ethnic study.BMC medical genetics, , 13 ,56 More Information

Natarajan, Madhu K; Strauss, Bradley H; Rokoss, Michael; Buller, Christopher E; Mancini, G B John; Xie, Changchun; Sheth, Tej N; Goodhart, David; Cohen, Eric A; Seidelin, Peter; Harper, William; Gerstein, Hertzel C Randomized trial of insulin versus usual care in reducing restenosis after coronary intervention in patients with diabetes. the STent Restenosis And Metabolism (STREAM) study.Cardiovascular revascularization medicine : including molecular interventions, , 13 (2 ) ,95-100 More Information

Xie, Changchun (2012. ) Weighted multiple testing correction for correlated tests.Statistics in medicine, , 31 (4 ) ,341-52 More Information

Do, Ron; Xie, Changchun; Zhang, Xiaohe; Männistö, Satu; Harald, Kennet; Islam, Shofiqul; Bailey, Swneke D; Rangarajan, Sumathy; McQueen, Matthew J; Diaz, Rafael; Lisheng, Liu; Wang, Xingyu; Silander, Kaisa; Peltonen, Leena; Yusuf, Salim; Salomaa, Veikko; Engert, James C; Anand, Sonia S (2011. ) The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study.PLoS medicine, , 8 (10 ) ,e1001106 More Information

Mercuri, Mathew; Mehta, Shamir; Xie, Changchun; Valettas, Nicholas; Velianou, James L; Natarajan, Madhu K (2011. ) Radial artery access as a predictor of increased radiation exposure during a diagnostic cardiac catheterization procedure.JACC. Cardiovascular interventions, , 4 (3 ) ,347-52 More Information

Chow, Clara K; Islam, Shofiqul; Bautista, Leonelo; Rumboldt, Zvonko; Yusufali, Afzal; Xie, Changchun; Anand, Sonia S; Engert, James C; Rangarajan, Sumathy; Yusuf, Salim (2011. ) Parental history and myocardial infarction risk across the world: the INTERHEART Study.Journal of the American College of Cardiology, , 57 (5 ) ,619-27 More Information

Assimes, Themistocles L; Hólm, Hilma; Kathiresan, Sekar; Reilly, Muredach P; Thorleifsson, Gudmar; Voight, Benjamin F; Erdmann, Jeanette; Willenborg, Christina; Vaidya, Dhananjay; Xie, Changchun; Patterson, Chris C; Morgan, Thomas M; Burnett, Mary Susan; Li, Mingyao; Hlatky, Mark A; Knowles, Joshua W; Thompson, John R; Absher, Devin; Iribarren, Carlos; Go, Alan; Fortmann, Stephen P; Sidney, Stephen; Risch, Neil; Tang, Hua; Myers, Richard M; Berger, Klaus; Stoll, Monika; Shah, Svati H; Thorgeirsson, Gudmundur; Andersen, Karl; Havulinna, Aki S; Herrera, J Enrique; Faraday, Nauder; Kim, Yoonhee; Kral, Brian G; Mathias, Rasika A; Ruczinski, Ingo; Suktitipat, Bhoom; Wilson, Alexander F; Yanek, Lisa R; Becker, Lewis C; Linsel-Nitschke, Patrick; Lieb, Wolfgang; König, Inke R; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Reinhard, Wibke; Winogradow, Janina; Grassl, Martina; Grosshennig, Anika; Preuss, Michael; Schreiber, Stefan; Wichmann, H-Erich; Meisinger, Christa; Yee, Jean; Friedlander, Yechiel; Do, Ron; Meigs, James B; Williams, Gordon; Nathan, David M; MacRae, Calum A; Qu, Liming; Wilensky, Robert L; Matthai, William H; Qasim, Atif N; Hakonarson, Hakon; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Knouff, Christopher W; Waterworth, Dawn M; Walker, Max C; Mooser, Vincent E; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Martinelli, Nicola; Olivieri, Oliviero; Trabetti, Elisabetta; Malerba, Giovanni; Pignatti, Pier Franco; Guiducci, Candace; Mirel, Daniel; Parkin, Melissa; Hirschhorn, Joel N; Asselta, Rosanna; Duga, Stefano; Musunuru, Kiran; Daly, Mark J; Purcell, Shaun; Eifert, Sandra; Braund, Peter S; Wright, Benjamin J; Balmforth, Anthony J; Ball, Stephen G ; Ouwehand, Willem H; Deloukas, Panos; Scholz, Michael; Cambien, Francois; Huge, Andreas; Scheffold, Thomas; Salomaa, Veikko; Girelli, Domenico; Granger, Christopher B; Peltonen, Leena; McKeown, Pascal P; Altshuler, David; Melander, Olle; Devaney, Joseph M; Epstein, Stephen E; Rader, Daniel J; Elosua, Roberto; Engert, James C; Anand, Sonia S; Hall, Alistair S; Ziegler, Andreas; O'Donnell, Christopher J; Spertus, John A; Siscovick, David; Schwartz, Stephen M; Becker, Diane; Thorsteinsdottir, Unnur; Stefansson, Kari; Schunkert, Heribert; Samani, Nilesh J; Quertermous, Thomas (2010. ) Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.Journal of the American College of Cardiology, , 56 (19 ) ,1552-63 More Information

Bailey, Swneke D; Xie, Changchun; Do, Ron; Montpetit, Alexandre; Diaz, Rafael; Mohan, Viswanathan; Keavney, Bernard; Yusuf, Salim; Gerstein, Hertzel C; Engert, James C; Anand, Sonia (2010. ) Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.Diabetes care, , 33 (10 ) ,2250-3 More Information

Mercuri, Mathew; Xie, Changchun; Levy, Michael; Valettas, Nicholas; Natarajan, Madhu K (2009. ) Predictors of increased radiation dose during percutaneous coronary intervention.The American journal of cardiology, , 104 (9 ) ,1241-4 More Information

Mercuri, Mat; Natarajan, Madhu K; Holder, Douglas H; Xie, Changchun; Gafni, Amiram (2009. ) Insight into capacity planning for cardiac catheterization services: policy lessons learned from "Looking in the Mirror" over a decade.Health policy (Amsterdam, Netherlands), , 91 (3 ) ,314-20 More Information

, ; Kathiresan, Sekar; Voight, Benjamin F; Purcell, Shaun; Musunuru, Kiran; Ardissino, Diego; Mannucci, Pier M; Anand, Sonia; Engert, James C; Samani, Nilesh J; Schunkert, Heribert; Erdmann, Jeanette; Reilly, Muredach P; Rader, Daniel J; Morgan, Thomas; Spertus, John A; Stoll, Monika; Girelli, Domenico; McKeown, Pascal P; Patterson, Chris C; Siscovick, David S; O'Donnell, Christopher J; Elosua, Roberto; Peltonen, Leena; Salomaa, Veikko; Schwartz, Stephen M; Melander, Olle; Altshuler, David; Ardissino, Diego; Merlini, Pier Angelica; Berzuini, Carlo; Bernardinelli, Luisa; Peyvandi, Flora; Tubaro, Marco; Celli, Patrizia; Ferrario, Maurizio; Fetiveau, Raffaela; Marziliano, Nicola; Casari, Giorgio; Galli, Michele; Ribichini, Flavio; Rossi, Marco; Bernardi, Francesco; Zonzin, Pietro; Piazza, Alberto; Mannucci, Pier M; Schwartz, Stephen M; Siscovick, David S; Yee, Jean; Friedlander, Yechiel; Elosua, Roberto; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Kathiresan, Sekar; Meigs, James B; Williams, Gordon; Nathan, David M; MacRae, Calum A; O'Donnell, Christopher J; Salomaa, Veikko; Havulinna, Aki S; Peltonen, Leena; Melander, Olle; Berglund, Goran; Voight, Benjamin F; Kathiresan, Sekar; Hirschhorn, Joel N; Asselta, Rosanna; Duga, Stefano; Spreafico, Marta; Musunuru, Kiran; Daly, Mark J; Purcell, Shaun; Voight, Benjamin F; Purcell, Shaun; Nemesh, James; Korn, Joshua M; McCarroll, Steven A; Schwartz, Stephen M; Yee, Jean; Kathiresan, Sekar; Lucas, Gavin; Subirana, Isaac; Elosua, Roberto; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Mirel, Daniel; Parkin, Melissa; Burtt, Noel; Gabriel, Stacey B; Samani, Nilesh J; Thompson, John R; Braund, Peter S; Wright, Benjamin J; Balmforth, Anthony J; Ball, Stephen G; Hall, Alistair S ; Schunkert, Heribert; Erdmann, Jeanette; Linsel-Nitschke, Patrick; Lieb, Wolfgang; Ziegler, Andreas; König, Inke; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Grosshennig, Anika; Preuss, Michael; Wichmann, H-Erich; Schreiber, Stefan; Schunkert, Heribert; Samani, Nilesh J; Erdmann, Jeanette; Ouwehand, Willem; Hengstenberg, Christian; Deloukas, Panos; Scholz, Michael; Cambien, Francois; Reilly, Muredach P; Li, Mingyao; Chen, Zhen; Wilensky, Robert; Matthai, William; Qasim, Atif; Hakonarson, Hakon H; Devaney, Joe; Burnett, Mary-Susan; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Knouff, Christopher W; Waterworth, Dawn M; Walker, Max C; Mooser, Vincent; Epstein, Stephen E; Rader, Daniel J; Scheffold, Thomas; Berger, Klaus; Stoll, Monika; Huge, Andreas; Girelli, Domenico; Martinelli, Nicola; Olivieri, Oliviero; Corrocher, Roberto; Morgan, Thomas; Spertus, John A; McKeown, Pascal; Patterson, Chris C; Schunkert, Heribert; Erdmann, Erdmann; Linsel-Nitschke, Patrick; Lieb, Wolfgang; Ziegler, Andreas; König, Inke R; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Grosshennig, Anika; Preuss, Michael; Wichmann, H-Erich; Schreiber, Stefan; Hólm, Hilma; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari; Engert, James C; Do, Ron; Xie, Changchun; Anand, Sonia; Kathiresan, Sekar; Ardissino, Diego; Mannucci, Pier M; Siscovick, David; O'Donnell, Christopher J; Samani, Nilesh J; Melander, Olle; Elosua, Roberto; Peltonen, Leena; Salomaa, Veikko; Schwartz, Stephen M; Altshuler, David (2009. ) Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.Nature genetics, , 41 (3 ) ,334-41 More Information

Anand, Sonia S; Xie, Changchun; Paré, Guillaume; Montpetit, Alexandre; Rangarajan, Sumathy; McQueen, Matthew J; Cordell, Heather J; Keavney, Bernard; Yusuf, Salim; Hudson, Thomas J; Engert, James C (2009. ) Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study.Circulation. Cardiovascular genetics, , 2 (1 ) ,16-25 More Information

de Koning, Lawrence; Merchant, Anwar T; Hegele, Robert A; Xie, Changchun; Vuksan, Vlad; Teo, Koon; Yusuf, Salim; Anand, Sonia S (2008. ) Association of the FABP2 T54 variant with plasma triglycerides and insulin resistance in a multiethnic population.Clinical chemistry, , 54 (10 ) ,1742-4 More Information

Xavier, Denis; Pais, Prem; Devereaux, P J; Xie, Changchun; Prabhakaran, D; Reddy, K Srinath; Gupta, Rajeev; Joshi, Prashant; Kerkar, Prafulla; Thanikachalam, S; Haridas, K K; Jaison, T M; Naik, Sudhir; Maity, A K; Yusuf, Salim (2008. ) Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data.Lancet, , 371 (9622 ) ,1435-42 More Information

Anand, Sonia S; Davis, A Darlene; Ahmed, Rashid; Jacobs, Ruby; Xie, Changchun; Hill, Amber; Sowden, Joon; Atkinson, Stephanie; Blimkie, Cameron; Brouwers, Melissa; Morrison, Katherine; de Koning, Larry; Gerstein, Hertzel; Yusuf, Salim A family-based intervention to promote healthy lifestyles in an aboriginal community in Canada. Canadian journal of public health = Revue canadienne de santé publique, , 98 (6 ) ,447-52

, ; Anand, Sonia; Yusuf, Salim; Xie, Changchun; Pogue, Janice; Eikelboom, John; Budaj, Andrzej; Sussex, Bruce; Liu, Lisheng; Guzman, Randy; Cina, Claudio; Crowell, Richard; Keltai, Matyas; Gosselin, Gilbert (2007. ) Oral anticoagulant and antiplatelet therapy and peripheral arterial disease.The New England journal of medicine, , 357 (3 ) ,217-27 More Information

Eikelboom, John W; Mehta, Shamir R; Anand, Sonia S; Xie, Changchun; Fox, Keith A A; Yusuf, Salim (2006. ) Adverse impact of bleeding on prognosis in patients with acute coronary syndromes.Circulation, , 114 (8 ) ,774-82 More Information

Schwalm, Jon-David Reid; Ahmad, Mayraj; Velianou, James L; Xie, Changchun; Natarajan, Madhu K (2006. ) Primary and rescue percutaneous coronary intervention with paclitaxel-eluting stent implantation in ST-elevation myocardial infarction.The American journal of cardiology, , 97 (9 ) ,1308-10 More Information

Mehta, Shamir R; Yusuf, Salim; Díaz, Rafael; Zhu, Jun; Pais, Prem; Xavier, Denis; Paolasso, Ernesto; Ahmed, Rashid; Xie, Changchun; Kazmi, Khawar; Tai, Javed; Orlandini, Andrés; Pogue, Janice; Liu, Lisheng (2005. ) Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial.JAMA, , 293 (4 ) ,437-46 More Information

Yusuf, Salim; Mehta, Shamir R; Xie, Changchun; Ahmed, Rashid J; Xavier, Denis; Pais, Prem; Zhu, Jun; Liu, Lisheng (2005. ) Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation.JAMA, , 293 (4 ) ,427-35 More Information

Yusuf, Salim; Mehta, Shamir R; Díaz, Rafael; Paolasso, Ernesto; Pais, Prem; Xavier, Denis; Xie, Changchun; Ahmed, Rashid J; Khazmi, Khawar; Zhu, Jun; Liu, Lisheng (2004. ) Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction.American heart journal, , 148 (6 ) ,1068-78 More Information

Lindsley, Andrew W; Saal, Howard M; Burrow, Thomas A; Hopkin, Robert J; Shchelochkov, Oleg; Khandelwal, Pooja; Xie, Changchun; Bleesing, Jack; Filipovich, Lisa; Risma, Kimberly; Assa'ad, Amal H; Roehrs, Phillip A; Bernstein, Jonathan A (2016. ) Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome.The Journal of allergy and clinical immunology, , 137 (1 ) ,179-187.e10 More Information

Wang, Ke-Sheng; Zuo, Lingjun; Pan, Yue; Xie, Changchun; Luo, Xingguang (2015. ) Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations.Journal of psychiatric research, , 71 ,1-7 More Information

Chen, Aimin; Xu, Fan; Xie, Changchun; Wu, Tianying; Vuong, Ann M; Miao, Maohua; Yuan, Wei; DeFranco, Emily A (2015. ) Gestational Weight Gain Trend and Population Attributable Risks of Adverse Fetal Growth Outcomes in Ohio.Paediatric and perinatal epidemiology, , 29 (4 ) ,346-50 More Information

Li, Yue; Xie, Changchun; Murphy, Susan K; Skaar, David; Nye, Monica; Vidal, Adriana C; Cecil, Kim M; Dietrich, Kim N; Puga, Alvaro; Jirtle, Randy L; Hoyo, Cathrine (2015. ) Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.Environmental health perspectives, , More Information

Kim, Stephani; Xu, Xijin; Zhang, Yuling; Zheng, Xiangbin; Liu, Rongju; Dietrich, Kim; Reponen, Tiina; Ho, Shuk-Mei; Xie, Changchun; Sucharew, Heidi; Huo, Xia; Chen, Aimin (2018. ) Metal concentrations in pregnant women and neonates from informal electronic waste recycling.Journal of exposure science & environmental epidemiology, , More Information

Vuong, Ann M; Braun, Joseph M; Yolton, Kimberly; Wang, Zhiyang; Xie, Changchun; Webster, Glenys M; Ye, Xiaoyun; Calafat, Antonia M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2018. ) Prenatal and childhood exposure to perfluoroalkyl substances (PFAS) and measures of attention, impulse control, and visual spatial abilities.Environment international, , 119 ,413-420 More Information

Vuong, Ann M; Yolton, Kimberly; Wang, Zhiyang; Xie, Changchun; Webster, Glenys M; Ye, Xiaoyun; Calafat, Antonia M; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2018. ) Childhood perfluoroalkyl substance exposure and executive function in children at 8?years.Environment international, , 119 ,212-219 More Information

Zhang, Hongmei; Yolton, Kimberly; Webster, Glenys M; Ye, Xiaoyun; Calafat, Antonia M; Dietrich, Kim N; Xu, Yingying; Xie, Changchun; Braun, Joseph M; Lanphear, Bruce P; Chen, Aimin (2018. ) Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8years.Environment international, , 111 ,224-231 More Information

Michalsky, Marc P; Inge, Thomas H; Jenkins, Todd M; Xie, Changchun; Courcoulas, Anita; Helmrath, Michael; Brandt, Mary L; Harmon, Carroll M; Chen, Mike; Dixon, John B; Urbina, Elaine M (2018. ) Cardiovascular Risk Factors After Adolescent Bariatric Surgery.Pediatrics, , 141 (2 ) , More Information

DeFoor, W Robert; Inge, Thomas H; Jenkins, Todd M; Jackson, Elizabeth; Courcoulas, Anita; Michalsky, Marc; Brandt, Mary; Kollar, Linda; Xie, Changchun (2018. ) Prospective evaluation of urinary incontinence in severely obese adolescents presenting for weight loss surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, , 14 (2 ) ,214-218 More Information

Leung, Yuet-Kin; Ouyang, Bin; Niu, Liang; Xie, Changchun; Ying, Jun; Medvedovic, Mario; Chen, Aimin; Weihe, Pal; Valvi, Damaskini; Grandjean, Philippe; Ho, Shuk-Mei (2018. ) Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort.Epigenetics, , 13 (3 ) ,290-300 More Information

Vuong, Ann M; Yolton, Kimberly; Poston, Kendra L; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2018. ) Childhood polybrominated diphenyl ether (PBDE) exposure and executive function in children in the HOME Study.International journal of hygiene and environmental health, , 221 (1 ) ,87-94 More Information

Karim, Nagla Abdel; Schuster, James; Eldessouki, Ihab; Gaber, Ola; Namad, Tariq; Wang, Jiang; Xie, Changchun; Morris, John C (2018. ) Pulmonary sarcomatoid carcinoma: University of Cincinnati experience.Oncotarget, , 9 (3 ) ,4102-4108 More Information

Gautam, Yadu; Altaye, Mekibib; Xie, Changchun; Mersha, Tesfaye B (2017. ) AdmixPower: Statistical Power and Sample Size Estimation for Mapping Genetic Loci in Admixed Populations.Genetics, , 207 (3 ) ,873-882 More Information

Vuong, Ann M; Yolton, Kimberly; Poston, Kendra L; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2017. ) Prenatal and postnatal polybrominated diphenyl ether (PBDE) exposure and measures of inattention and impulsivity in children.Neurotoxicology and teratology, , 64 ,20-28 More Information

Vuong, Ann M; Yolton, Kimberly; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2017. ) Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years.Environmental research, , 158 ,677-684 More Information

Wang, Ke-Sheng; Liu, Xuefeng; Ategbole, Muyiwa; Xie, Xin; Liu, Ying; Xu, Chun; Xie, Changchun; Sha, Zhanxin (2017. ) Generalized Linear Mixed Model Analysis of Urban-Rural Differences in Social and Behavioral Factors for Colorectal Cancer Screening.Asian Pacific journal of cancer prevention : APJCP, , 18 (9 ) ,2581-2589 More Information

Herrick, Robert L; Buckholz, Jeanette; Biro, Frank M; Calafat, Antonia M; Ye, Xiaoyun; Xie, Changchun; Pinney, Susan M (2017. ) Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012.Environmental pollution (Barking, Essex : 1987), , 228 ,50-60 More Information

Zhang, Hongmei; Yolton, Kimberly; Webster, Glenys M; Sjödin, Andreas; Calafat, Antonia M; Dietrich, Kim N; Xu, Yingying; Xie, Changchun; Braun, Joseph M; Lanphear, Bruce P; Chen, Aimin (2017. ) Erratum: "Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children".Environmental health perspectives, , 125 (6 ) ,069001 More Information

Zhang, Hongmei; Yolton, Kimberly; Webster, Glenys M; Sjödin, Andreas; Calafat, Antonia M; Dietrich, Kim N; Xu, Yingying; Xie, Changchun; Braun, Joseph M; Lanphear, Bruce P; Chen, Aimin (2017. ) Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children.Environmental health perspectives, , 125 (4 ) ,746-752 More Information

Vuong, Ann M; Braun, Joseph M; Yolton, Kimberly; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2017. ) Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children.Environmental research, , 153 ,83-92 More Information

Martin, Andrew T; Pinney, Susan M; Xie, Changchun; Herrick, Robert L; Bai, Yun; Buckholz, Jeanette; Martin, Vincent T (2017. ) Headache Disorders May Be a Risk Factor for the Development of New Onset Hypothyroidism.Headache, , 57 (1 ) ,21-30 More Information

Owusu, Daniel; Pan, Yue; Xie, Changchun; Harirforoosh, Sam; Wang, Ke-Sheng (2017. ) Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension.Journal of psychiatric research, , 84 ,27-34 More Information

Agarwal, Rishi; Sendilnathan, Arun; Siddiqi, Nabeela Iffat; Gulati, Shuchi; Ghose, Abhimanyu; Xie, Changchun; Olowokure, Olugbenga Olanrele (2016. ) Advanced biliary tract cancer: clinical outcomes with ABC-02 regimen and analysis of prognostic factors in a tertiary care center in the United States.Journal of gastrointestinal oncology, , 7 (6 ) ,996-1003 More Information

Wang, Ke-Sheng; Liu, Xuefeng; Xie, Changchun; Liu, Ying; Xu, Chun (2016. ) Non-parametric Survival Analysis of EPG5 Gene with Age at Onset of Alzheimer's Disease.Journal of molecular neuroscience : MN, , 60 (4 ) ,436-444 More Information

Agarwal, Sunil; Mark, Jonathan; Xie, Changchun; Ghulam, Enas; Patil, Yash (2016. ) Survival and Prognosis for Malignant Tumors of Odontogenic Origin.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, , 155 (1 ) ,113-6 More Information

Wang, Ke-Sheng; Owusu, Daniel; Pan, Yue; Xie, Changchun (2016. ) Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus. Journal of genetics, , 95 (2 ) ,331-40

Rebholz, Sandra L; Jones, Thomas; Herrick, Robert L; Xie, Changchun; Calafat, Antonia M; Pinney, Susan M; Woollett, Laura A Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice.Toxicology reports, , 3 ,46-54 More Information

Xie, Changchun (2015. ) Resveratrol does not reduce CVD risk, prolong life - A statistical point of view.Contemporary clinical trials communications, , 1 ,1 More Information

Academic - Division of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati
104 Kettering Lab, 160 Panzeca Way
Cincinnati  Ohio, 45267
Phone: (513)-558-0229
xiecn@ucmail.uc.edu