Changchun Xie

Changchun Xie

Professor of Biostatistics

Kettering Lab Complex

104

COM EH Bio Xie Lab - 0056

Division of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati
104 Kettering Lab, 160 Panzeca Way
Cincinnati, Ohio 45267

Education

Ph.D., University of Guelph Canada, 2003 (Statistics)

M.S., Dalhousie University Canada, 1999 (Statistics)

M.S., Zhejiang University China, 1992 (Mathematical statistics)

B.S., Hunan Normal University China, 1989 (Mathematics)

Research Support

Grant: #R21ES024717 Investigators:Bhattacharya, Amit; Haynes, Erin; Heineman, William; Papautsky, Ian; Wilsey, Philip; Xie, Changchun 03-01-2015 -02-28-2017 National Institute of Environmental Health Sciences Validation and Demonstration of Point-of-Care Sensor for Multi-Metal Exposure Assessment Role:Collaborator $197,708.00 Awarded Level:Federal

Grant: #R21NS093493-01 Investigators:Hao, Jiukuan; Xie, Changchun 06-01-2015 -05-31-2017 National Institute of Neurological Disorders and Stroke Application of Brain-Targeted Anti-inflammatory RNA Nanoparticle for Ischemic Stroke Therapy Role:Collaborator $205,506.00 Awarded Level:Federal

Grant: #R01DK105379 Investigators:Attari, Mehran; Salehi, Marzieh; Xie, Changchun 07-01-2015 -05-31-2020 National Inst of Diabetes and Digestive and Kidney Disease The weight-independent effects of bariatric surgeries on islet cell function Role:Collaborator $555,488.00 Awarded Level:Federal

Grant: #RC105513UC/U01ES026119 Investigators:Pinney, Susan; Xie, Changchun 09-30-2015 -06-30-2020 National Institute of Environmental Health Sciences Mammary carcinogenesis: pubertal and adult effects of high fat diet+oxybenzone Role:Collaborator $35,343.00 Awarded Level:Federal

Grant: #Harry J. Lloyd Charitable Trust 2015-17 Investigators:Abdelmalek, Zalfa; Xie, Changchun; Zhang, Yuhang 06-01-2015 -05-31-2017 Harry J. Lloyd Charitable Trust Reprogramming the Tumor Microenvironment to Treat Melanoma Role:Collaborator $200,000.00 Active Level:Private Non-Profit

Grant: #UM1DK095710 Investigators:Xie, Changchun 09-01-2016 -08-31-2021 National Inst of Diabetes and Digestive and Kidney Disease Continuation of Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS), Biostatistics Research Center Role:PI $1,066,072.00 Active Level:Federal

Grant: #136802 / R01 HL132344 Investigators:Xie, Changchun 04-01-2016 -03-31-2021 National Heart, Lung and Blood Institute Unraveling ancestry and environmental exposure interactions in childhood asthma Role:PI $26,569.00 Active Level:Federal

Grant: #ES028277 Investigators:Chen, Aimin; Dietrich, Kim; Xie, Changchun 09-30-2017 -06-30-2022 National Institute of Environmental Health Sciences Developmental neurotoxicity of organophosphate and novel brominated flame retardants in children Role:Collaborator $664,377.00 Awarded Level:Federal

Grant: #R01ES027855 Investigators:Pinney, Susan; Rubinstein, Jack; Wang, Hongsheng; Xie, Changchun 02-01-2018 -01-31-2023 National Institute of Environmental Health Sciences Endocrine Disruptors and Heart Health Role:Collaborator $429,032.00 Active Level:Federal

Grant: #R01ES029133 Investigators:Chen, Aimin; Pinney, Susan; Xie, Changchun 08-15-2018 -06-30-2021 National Institute of Environmental Health Sciences Longitudinal study of endocrine disrupting chemical exposure and the early hormonal milieu of girls around the time of thelarche Role:Collaborator $394,749.00 Active Level:Federal

Grant: #R24ES028527 Investigators:Leung, Yuet Kin; Pinney, Susan; Reichard, John; Xie, Changchun 09-30-2018 -06-30-2023 National Institute of Environmental Health Sciences Fernald Community Cohort: Research Resource for Environmental Epidemiology Role:Collaborator $399,875.00 Active Level:Federal

Publications

Peer Reviewed Publications

Chen, Yaolong; Yang, Kehu; Jing, Tao; Tian, Jinhui; Shen, Xiping; Xie, Changchun; Ma, Bin; Liu, Yali; Yao, Liang; Cao, Xiaoyuan (2014. )Use of text messages to communicate clinical recommendations to health workers in rural China: a cluster-randomized trial.Bulletin of the World Health Organization, ,92 (7 ),474-81

Bailey, Swneke D; Xie, Changchun; Paré, Guillaume; Montpetit, Alexandre; Mohan, Viswanathan; Yusuf, Salim; Gerstein, Hertzel; Engert, James C; Anand, Sonia S (2014. )Variation at the DPP4 locus influences apolipoprotein B levels in South Asians and exhibits heterogeneity in Europeans related to BMI.Diabetologia, ,57 (4 ),738-45

Xie, Changchun (2014. )Relations among Three Parametric Multiple Testing Methods for Correlated Tests.Journal of statistical computation and simulation, ,84 (4 ),812-818

Zhou, Tao; Li, Xia; Tang, Zhe; Xie, Changchun; Tao, Lixin; Pan, Lei; Huo, Da; Sun, Fei; Luo, Yanxia; Wang, Wei; Yan, Aoshuang; Guo, Xiuhua (2014. )Risk factors of CVD mortality among the elderly in Beijing, 1992 - 2009: an 18-year cohort study.International journal of environmental research and public health, ,11 (2 ),2193-208

Tang, Zhe; Zhou, Tao; Luo, Yanxia; Xie, Changchun; Huo, Da; Tao, Lixin; Pan, Lei; Sun, Fei; Zhu, Huiping; Yang, Xinghua; Wang, Wei; Yan, Aoshuang; Li, Xia; Guo, Xiuhua (2014. )Risk factors for cerebrovascular disease mortality among the elderly in Beijing: a competing risk analysis.PloS one, ,9 (2 ),e87884

Kirsh, Elliana R; van Leer, Eva; Phero, Heidi J; Xie, Changchun; Khosla, Sid (2013. )Factors associated with singers' perceptions of choral singing well-being.Journal of voice : official journal of the Voice Foundation, ,27 (6 ),786.e25-32

Anand, Sonia S; Meyre, David; Pare, Guillaume; Bailey, Swneke D; Xie, Changchun; Zhang, Xiaohe; Montpetit, Alexandre; Desai, Dipika; Bosch, Jackie; Mohan, Viswanathan; Diaz, Rafael; McQueen, Matthew J; Cordell, Heather J; Keavney, Bernard; Yusuf, Salim; Gaudet, Daniel; Gerstein, Hertzel; Engert, James C (2013. )Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study.Diabetes care, ,36 (9 ),2836-42

Xie, Changchun; Chen, Ding-Geng (2013. )Letter to the editor.Biometrical journal. Biometrische Zeitschrift, ,55 (2 ),264-5

Yamanaka, Osamu; Yuan, Yong; Coulson-Thomas, Vivien Jane; Gesteira, Tarsis Ferreira; Call, Mindy K; Zhang, Yujin; Zhang, Jianhua; Chang, Shao-Hsuan; Xie, Changchun; Liu, Chia-Yang; Saika, Shizuya; Jester, James V; Kao, Winston W-Y (2013. )Lumican binds ALK5 to promote epithelium wound healing.PloS one, ,8 (12 ),e82730

Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, A Darlene; Miller, Ruby; Lanktree, Matthew B; Saleheen, Danish; Danesh, John; Yusuf, Salim; Engert, James C; Hegele, Robert A; Anand, Sonia S (2012. )BRCA2 variants and cardiovascular disease in a multi-ethnic study.BMC medical genetics, ,13 ,56

Natarajan, Madhu K; Strauss, Bradley H; Rokoss, Michael; Buller, Christopher E; Mancini, G B John; Xie, Changchun; Sheth, Tej N; Goodhart, David; Cohen, Eric A; Seidelin, Peter; Harper, William; Gerstein, Hertzel C Randomized trial of insulin versus usual care in reducing restenosis after coronary intervention in patients with diabetes. the STent Restenosis And Metabolism (STREAM) study.Cardiovascular revascularization medicine : including molecular interventions, ,13 (2 ),95-100

Xie, Changchun (2012. )Weighted multiple testing correction for correlated tests.Statistics in medicine, ,31 (4 ),341-52

Do, Ron; Xie, Changchun; Zhang, Xiaohe; Männistö, Satu; Harald, Kennet; Islam, Shofiqul; Bailey, Swneke D; Rangarajan, Sumathy; McQueen, Matthew J; Diaz, Rafael; Lisheng, Liu; Wang, Xingyu; Silander, Kaisa; Peltonen, Leena; Yusuf, Salim; Salomaa, Veikko; Engert, James C; Anand, Sonia S (2011. )The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study.PLoS medicine, ,8 (10 ),e1001106

Mercuri, Mathew; Mehta, Shamir; Xie, Changchun; Valettas, Nicholas; Velianou, James L; Natarajan, Madhu K (2011. )Radial artery access as a predictor of increased radiation exposure during a diagnostic cardiac catheterization procedure.JACC. Cardiovascular interventions, ,4 (3 ),347-52

Chow, Clara K; Islam, Shofiqul; Bautista, Leonelo; Rumboldt, Zvonko; Yusufali, Afzal; Xie, Changchun; Anand, Sonia S; Engert, James C; Rangarajan, Sumathy; Yusuf, Salim (2011. )Parental history and myocardial infarction risk across the world: the INTERHEART Study.Journal of the American College of Cardiology, ,57 (5 ),619-27

Assimes, Themistocles L; Hólm, Hilma; Kathiresan, Sekar; Reilly, Muredach P; Thorleifsson, Gudmar; Voight, Benjamin F; Erdmann, Jeanette; Willenborg, Christina; Vaidya, Dhananjay; Xie, Changchun; Patterson, Chris C; Morgan, Thomas M; Burnett, Mary Susan; Li, Mingyao; Hlatky, Mark A; Knowles, Joshua W; Thompson, John R; Absher, Devin; Iribarren, Carlos; Go, Alan; Fortmann, Stephen P; Sidney, Stephen; Risch, Neil; Tang, Hua; Myers, Richard M; Berger, Klaus; Stoll, Monika; Shah, Svati H; Thorgeirsson, Gudmundur; Andersen, Karl; Havulinna, Aki S; Herrera, J Enrique; Faraday, Nauder; Kim, Yoonhee; Kral, Brian G; Mathias, Rasika A; Ruczinski, Ingo; Suktitipat, Bhoom; Wilson, Alexander F; Yanek, Lisa R; Becker, Lewis C; Linsel-Nitschke, Patrick; Lieb, Wolfgang; König, Inke R; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Reinhard, Wibke; Winogradow, Janina; Grassl, Martina; Grosshennig, Anika; Preuss, Michael; Schreiber, Stefan; Wichmann, H-Erich; Meisinger, Christa; Yee, Jean; Friedlander, Yechiel; Do, Ron; Meigs, James B; Williams, Gordon; Nathan, David M; MacRae, Calum A; Qu, Liming; Wilensky, Robert L; Matthai, William H; Qasim, Atif N; Hakonarson, Hakon; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Knouff, Christopher W; Waterworth, Dawn M; Walker, Max C; Mooser, Vincent E; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Martinelli, Nicola; Olivieri, Oliviero; Trabetti, Elisabetta; Malerba, Giovanni; Pignatti, Pier Franco; Guiducci, Candace; Mirel, Daniel; Parkin, Melissa; Hirschhorn, Joel N; Asselta, Rosanna; Duga, Stefano; Musunuru, Kiran; Daly, Mark J; Purcell, Shaun; Eifert, Sandra; Braund, Peter S; Wright, Benjamin J; Balmforth, Anthony J; Ball, Stephen G ; Ouwehand, Willem H; Deloukas, Panos; Scholz, Michael; Cambien, Francois; Huge, Andreas; Scheffold, Thomas; Salomaa, Veikko; Girelli, Domenico; Granger, Christopher B; Peltonen, Leena; McKeown, Pascal P; Altshuler, David; Melander, Olle; Devaney, Joseph M; Epstein, Stephen E; Rader, Daniel J; Elosua, Roberto; Engert, James C; Anand, Sonia S; Hall, Alistair S; Ziegler, Andreas; O'Donnell, Christopher J; Spertus, John A; Siscovick, David; Schwartz, Stephen M; Becker, Diane; Thorsteinsdottir, Unnur; Stefansson, Kari; Schunkert, Heribert; Samani, Nilesh J; Quertermous, Thomas (2010. )Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.Journal of the American College of Cardiology, ,56 (19 ),1552-63

Bailey, Swneke D; Xie, Changchun; Do, Ron; Montpetit, Alexandre; Diaz, Rafael; Mohan, Viswanathan; Keavney, Bernard; Yusuf, Salim; Gerstein, Hertzel C; Engert, James C; Anand, Sonia (2010. )Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.Diabetes care, ,33 (10 ),2250-3

Mercuri, Mathew; Xie, Changchun; Levy, Michael; Valettas, Nicholas; Natarajan, Madhu K (2009. )Predictors of increased radiation dose during percutaneous coronary intervention.The American journal of cardiology, ,104 (9 ),1241-4

Mercuri, Mat; Natarajan, Madhu K; Holder, Douglas H; Xie, Changchun; Gafni, Amiram (2009. )Insight into capacity planning for cardiac catheterization services: policy lessons learned from "Looking in the Mirror" over a decade.Health policy (Amsterdam, Netherlands), ,91 (3 ),314-20

, ; Kathiresan, Sekar; Voight, Benjamin F; Purcell, Shaun; Musunuru, Kiran; Ardissino, Diego; Mannucci, Pier M; Anand, Sonia; Engert, James C; Samani, Nilesh J; Schunkert, Heribert; Erdmann, Jeanette; Reilly, Muredach P; Rader, Daniel J; Morgan, Thomas; Spertus, John A; Stoll, Monika; Girelli, Domenico; McKeown, Pascal P; Patterson, Chris C; Siscovick, David S; O'Donnell, Christopher J; Elosua, Roberto; Peltonen, Leena; Salomaa, Veikko; Schwartz, Stephen M; Melander, Olle; Altshuler, David; Ardissino, Diego; Merlini, Pier Angelica; Berzuini, Carlo; Bernardinelli, Luisa; Peyvandi, Flora; Tubaro, Marco; Celli, Patrizia; Ferrario, Maurizio; Fetiveau, Raffaela; Marziliano, Nicola; Casari, Giorgio; Galli, Michele; Ribichini, Flavio; Rossi, Marco; Bernardi, Francesco; Zonzin, Pietro; Piazza, Alberto; Mannucci, Pier M; Schwartz, Stephen M; Siscovick, David S; Yee, Jean; Friedlander, Yechiel; Elosua, Roberto; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Kathiresan, Sekar; Meigs, James B; Williams, Gordon; Nathan, David M; MacRae, Calum A; O'Donnell, Christopher J; Salomaa, Veikko; Havulinna, Aki S; Peltonen, Leena; Melander, Olle; Berglund, Goran; Voight, Benjamin F; Kathiresan, Sekar; Hirschhorn, Joel N; Asselta, Rosanna; Duga, Stefano; Spreafico, Marta; Musunuru, Kiran; Daly, Mark J; Purcell, Shaun; Voight, Benjamin F; Purcell, Shaun; Nemesh, James; Korn, Joshua M; McCarroll, Steven A; Schwartz, Stephen M; Yee, Jean; Kathiresan, Sekar; Lucas, Gavin; Subirana, Isaac; Elosua, Roberto; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Mirel, Daniel; Parkin, Melissa; Burtt, Noel; Gabriel, Stacey B; Samani, Nilesh J; Thompson, John R; Braund, Peter S; Wright, Benjamin J; Balmforth, Anthony J; Ball, Stephen G; Hall, Alistair S ; Schunkert, Heribert; Erdmann, Jeanette; Linsel-Nitschke, Patrick; Lieb, Wolfgang; Ziegler, Andreas; König, Inke; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Grosshennig, Anika; Preuss, Michael; Wichmann, H-Erich; Schreiber, Stefan; Schunkert, Heribert; Samani, Nilesh J; Erdmann, Jeanette; Ouwehand, Willem; Hengstenberg, Christian; Deloukas, Panos; Scholz, Michael; Cambien, Francois; Reilly, Muredach P; Li, Mingyao; Chen, Zhen; Wilensky, Robert; Matthai, William; Qasim, Atif; Hakonarson, Hakon H; Devaney, Joe; Burnett, Mary-Susan; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Knouff, Christopher W; Waterworth, Dawn M; Walker, Max C; Mooser, Vincent; Epstein, Stephen E; Rader, Daniel J; Scheffold, Thomas; Berger, Klaus; Stoll, Monika; Huge, Andreas; Girelli, Domenico; Martinelli, Nicola; Olivieri, Oliviero; Corrocher, Roberto; Morgan, Thomas; Spertus, John A; McKeown, Pascal; Patterson, Chris C; Schunkert, Heribert; Erdmann, Erdmann; Linsel-Nitschke, Patrick; Lieb, Wolfgang; Ziegler, Andreas; König, Inke R; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Grosshennig, Anika; Preuss, Michael; Wichmann, H-Erich; Schreiber, Stefan; Hólm, Hilma; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari; Engert, James C; Do, Ron; Xie, Changchun; Anand, Sonia; Kathiresan, Sekar; Ardissino, Diego; Mannucci, Pier M; Siscovick, David; O'Donnell, Christopher J; Samani, Nilesh J; Melander, Olle; Elosua, Roberto; Peltonen, Leena; Salomaa, Veikko; Schwartz, Stephen M; Altshuler, David (2009. )Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.Nature genetics, ,41 (3 ),334-41

Anand, Sonia S; Xie, Changchun; Paré, Guillaume; Montpetit, Alexandre; Rangarajan, Sumathy; McQueen, Matthew J; Cordell, Heather J; Keavney, Bernard; Yusuf, Salim; Hudson, Thomas J; Engert, James C (2009. )Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study.Circulation. Cardiovascular genetics, ,2 (1 ),16-25

de Koning, Lawrence; Merchant, Anwar T; Hegele, Robert A; Xie, Changchun; Vuksan, Vlad; Teo, Koon; Yusuf, Salim; Anand, Sonia S (2008. )Association of the FABP2 T54 variant with plasma triglycerides and insulin resistance in a multiethnic population.Clinical chemistry, ,54 (10 ),1742-4

Xavier, Denis; Pais, Prem; Devereaux, P J; Xie, Changchun; Prabhakaran, D; Reddy, K Srinath; Gupta, Rajeev; Joshi, Prashant; Kerkar, Prafulla; Thanikachalam, S; Haridas, K K; Jaison, T M; Naik, Sudhir; Maity, A K; Yusuf, Salim (2008. )Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data.Lancet, ,371 (9622 ),1435-42

Anand, Sonia S; Davis, A Darlene; Ahmed, Rashid; Jacobs, Ruby; Xie, Changchun; Hill, Amber; Sowden, Joon; Atkinson, Stephanie; Blimkie, Cameron; Brouwers, Melissa; Morrison, Katherine; de Koning, Larry; Gerstein, Hertzel; Yusuf, Salim A family-based intervention to promote healthy lifestyles in an aboriginal community in Canada. Canadian journal of public health = Revue canadienne de santé publique, ,98 (6 ),447-52

, ; Anand, Sonia; Yusuf, Salim; Xie, Changchun; Pogue, Janice; Eikelboom, John; Budaj, Andrzej; Sussex, Bruce; Liu, Lisheng; Guzman, Randy; Cina, Claudio; Crowell, Richard; Keltai, Matyas; Gosselin, Gilbert (2007. )Oral anticoagulant and antiplatelet therapy and peripheral arterial disease.The New England journal of medicine, ,357 (3 ),217-27

Eikelboom, John W; Mehta, Shamir R; Anand, Sonia S; Xie, Changchun; Fox, Keith A A; Yusuf, Salim (2006. )Adverse impact of bleeding on prognosis in patients with acute coronary syndromes.Circulation, ,114 (8 ),774-82

Schwalm, Jon-David Reid; Ahmad, Mayraj; Velianou, James L; Xie, Changchun; Natarajan, Madhu K (2006. )Primary and rescue percutaneous coronary intervention with paclitaxel-eluting stent implantation in ST-elevation myocardial infarction.The American journal of cardiology, ,97 (9 ),1308-10

Mehta, Shamir R; Yusuf, Salim; Díaz, Rafael; Zhu, Jun; Pais, Prem; Xavier, Denis; Paolasso, Ernesto; Ahmed, Rashid; Xie, Changchun; Kazmi, Khawar; Tai, Javed; Orlandini, Andrés; Pogue, Janice; Liu, Lisheng (2005. )Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial.JAMA, ,293 (4 ),437-46

Yusuf, Salim; Mehta, Shamir R; Xie, Changchun; Ahmed, Rashid J; Xavier, Denis; Pais, Prem; Zhu, Jun; Liu, Lisheng (2005. )Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation.JAMA, ,293 (4 ),427-35

Yusuf, Salim; Mehta, Shamir R; Díaz, Rafael; Paolasso, Ernesto; Pais, Prem; Xavier, Denis; Xie, Changchun; Ahmed, Rashid J; Khazmi, Khawar; Zhu, Jun; Liu, Lisheng (2004. )Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction.American heart journal, ,148 (6 ),1068-78

Lindsley, Andrew W; Saal, Howard M; Burrow, Thomas A; Hopkin, Robert J; Shchelochkov, Oleg; Khandelwal, Pooja; Xie, Changchun; Bleesing, Jack; Filipovich, Lisa; Risma, Kimberly; Assa'ad, Amal H; Roehrs, Phillip A; Bernstein, Jonathan A (2016. )Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome.The Journal of allergy and clinical immunology, ,137 (1 ),179-187.e10

Wang, Ke-Sheng; Zuo, Lingjun; Pan, Yue; Xie, Changchun; Luo, Xingguang (2015. )Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations.Journal of psychiatric research, ,71 ,1-7

Chen, Aimin; Xu, Fan; Xie, Changchun; Wu, Tianying; Vuong, Ann M; Miao, Maohua; Yuan, Wei; DeFranco, Emily A (2015. )Gestational Weight Gain Trend and Population Attributable Risks of Adverse Fetal Growth Outcomes in Ohio.Paediatric and perinatal epidemiology, ,29 (4 ),346-50

Li, Yue; Xie, Changchun; Murphy, Susan K; Skaar, David; Nye, Monica; Vidal, Adriana C; Cecil, Kim M; Dietrich, Kim N; Puga, Alvaro; Jirtle, Randy L; Hoyo, Cathrine (2015. )Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.Environmental health perspectives, ,

Kim, Stephani; Xu, Xijin; Zhang, Yuling; Zheng, Xiangbin; Liu, Rongju; Dietrich, Kim; Reponen, Tiina; Ho, Shuk-Mei; Xie, Changchun; Sucharew, Heidi; Huo, Xia; Chen, Aimin (2018. )Metal concentrations in pregnant women and neonates from informal electronic waste recycling.Journal of exposure science & environmental epidemiology, ,

Vuong, Ann M; Braun, Joseph M; Yolton, Kimberly; Wang, Zhiyang; Xie, Changchun; Webster, Glenys M; Ye, Xiaoyun; Calafat, Antonia M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2018. )Prenatal and childhood exposure to perfluoroalkyl substances (PFAS) and measures of attention, impulse control, and visual spatial abilities.Environment international, ,119 ,413-420

Vuong, Ann M; Yolton, Kimberly; Wang, Zhiyang; Xie, Changchun; Webster, Glenys M; Ye, Xiaoyun; Calafat, Antonia M; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2018. )Childhood perfluoroalkyl substance exposure and executive function in children at 8?years.Environment international, ,119 ,212-219

Zhang, Hongmei; Yolton, Kimberly; Webster, Glenys M; Ye, Xiaoyun; Calafat, Antonia M; Dietrich, Kim N; Xu, Yingying; Xie, Changchun; Braun, Joseph M; Lanphear, Bruce P; Chen, Aimin (2018. )Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8years.Environment international, ,111 ,224-231

Michalsky, Marc P; Inge, Thomas H; Jenkins, Todd M; Xie, Changchun; Courcoulas, Anita; Helmrath, Michael; Brandt, Mary L; Harmon, Carroll M; Chen, Mike; Dixon, John B; Urbina, Elaine M (2018. )Cardiovascular Risk Factors After Adolescent Bariatric Surgery.Pediatrics, ,141 (2 ),

DeFoor, W Robert; Inge, Thomas H; Jenkins, Todd M; Jackson, Elizabeth; Courcoulas, Anita; Michalsky, Marc; Brandt, Mary; Kollar, Linda; Xie, Changchun (2018. )Prospective evaluation of urinary incontinence in severely obese adolescents presenting for weight loss surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, ,14 (2 ),214-218

Leung, Yuet-Kin; Ouyang, Bin; Niu, Liang; Xie, Changchun; Ying, Jun; Medvedovic, Mario; Chen, Aimin; Weihe, Pal; Valvi, Damaskini; Grandjean, Philippe; Ho, Shuk-Mei (2018. )Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort.Epigenetics, ,13 (3 ),290-300

Vuong, Ann M; Yolton, Kimberly; Poston, Kendra L; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2018. )Childhood polybrominated diphenyl ether (PBDE) exposure and executive function in children in the HOME Study.International journal of hygiene and environmental health, ,221 (1 ),87-94

Karim, Nagla Abdel; Schuster, James; Eldessouki, Ihab; Gaber, Ola; Namad, Tariq; Wang, Jiang; Xie, Changchun; Morris, John C (2018. )Pulmonary sarcomatoid carcinoma: University of Cincinnati experience.Oncotarget, ,9 (3 ),4102-4108

Gautam, Yadu; Altaye, Mekibib; Xie, Changchun; Mersha, Tesfaye B (2017. )AdmixPower: Statistical Power and Sample Size Estimation for Mapping Genetic Loci in Admixed Populations.Genetics, ,207 (3 ),873-882

Vuong, Ann M; Yolton, Kimberly; Poston, Kendra L; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2017. )Prenatal and postnatal polybrominated diphenyl ether (PBDE) exposure and measures of inattention and impulsivity in children.Neurotoxicology and teratology, ,64 ,20-28

Vuong, Ann M; Yolton, Kimberly; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2017. )Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years.Environmental research, ,158 ,677-684

Wang, Ke-Sheng; Liu, Xuefeng; Ategbole, Muyiwa; Xie, Xin; Liu, Ying; Xu, Chun; Xie, Changchun; Sha, Zhanxin (2017. )Generalized Linear Mixed Model Analysis of Urban-Rural Differences in Social and Behavioral Factors for Colorectal Cancer Screening.Asian Pacific journal of cancer prevention : APJCP, ,18 (9 ),2581-2589

Herrick, Robert L; Buckholz, Jeanette; Biro, Frank M; Calafat, Antonia M; Ye, Xiaoyun; Xie, Changchun; Pinney, Susan M (2017. )Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012.Environmental pollution (Barking, Essex : 1987), ,228 ,50-60

Zhang, Hongmei; Yolton, Kimberly; Webster, Glenys M; Sjödin, Andreas; Calafat, Antonia M; Dietrich, Kim N; Xu, Yingying; Xie, Changchun; Braun, Joseph M; Lanphear, Bruce P; Chen, Aimin (2017. )Erratum: "Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children".Environmental health perspectives, ,125 (6 ),069001

Zhang, Hongmei; Yolton, Kimberly; Webster, Glenys M; Sjödin, Andreas; Calafat, Antonia M; Dietrich, Kim N; Xu, Yingying; Xie, Changchun; Braun, Joseph M; Lanphear, Bruce P; Chen, Aimin (2017. )Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children.Environmental health perspectives, ,125 (4 ),746-752

Vuong, Ann M; Braun, Joseph M; Yolton, Kimberly; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin (2017. )Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children.Environmental research, ,153 ,83-92

Martin, Andrew T; Pinney, Susan M; Xie, Changchun; Herrick, Robert L; Bai, Yun; Buckholz, Jeanette; Martin, Vincent T (2017. )Headache Disorders May Be a Risk Factor for the Development of New Onset Hypothyroidism.Headache, ,57 (1 ),21-30

Owusu, Daniel; Pan, Yue; Xie, Changchun; Harirforoosh, Sam; Wang, Ke-Sheng (2017. )Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension.Journal of psychiatric research, ,84 ,27-34

Agarwal, Rishi; Sendilnathan, Arun; Siddiqi, Nabeela Iffat; Gulati, Shuchi; Ghose, Abhimanyu; Xie, Changchun; Olowokure, Olugbenga Olanrele (2016. )Advanced biliary tract cancer: clinical outcomes with ABC-02 regimen and analysis of prognostic factors in a tertiary care center in the United States.Journal of gastrointestinal oncology, ,7 (6 ),996-1003

Wang, Ke-Sheng; Liu, Xuefeng; Xie, Changchun; Liu, Ying; Xu, Chun (2016. )Non-parametric Survival Analysis of EPG5 Gene with Age at Onset of Alzheimer's Disease.Journal of molecular neuroscience : MN, ,60 (4 ),436-444

Agarwal, Sunil; Mark, Jonathan; Xie, Changchun; Ghulam, Enas; Patil, Yash (2016. )Survival and Prognosis for Malignant Tumors of Odontogenic Origin.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, ,155 (1 ),113-6

Wang, Ke-Sheng; Owusu, Daniel; Pan, Yue; Xie, Changchun (2016. )Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus. Journal of genetics, ,95 (2 ),331-40

Rebholz, Sandra L; Jones, Thomas; Herrick, Robert L; Xie, Changchun; Calafat, Antonia M; Pinney, Susan M; Woollett, Laura A Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice.Toxicology reports, ,3 ,46-54

Xie, Changchun (2015. )Resveratrol does not reduce CVD risk, prolong life - A statistical point of view.Contemporary clinical trials communications, ,1 ,1

Positions and Work Experience

2001 -2001 Biostatistician, • Developed a new statistical method for bioavailability and bioequivalence analysis • Updated SAS program for analysis of bioavailability and bioequivalence studies , Therapeutic Products Directorate, Health Products and Food Branch, Health Canada, Ottawa, Canada

2002 -2007 Senior Statistical Analyst/Programmer, • Developing new statistical methods for analyzing multicentre clinical trials • Analyzing and publishing the results of Clinical Trials • Combining two large multicentre international clinical trials • Developing/validating SAS/SAS macro programs for large data management and statistical analysis • Developed practical Output Delivery System (ODS) Techniques for systematically and automatically generating high quality DSMB reports • Developing genetic statistical methods and analyzing large genetic data , PHRI, Department of Medicine, McMaster University, Hamilton, Canada

2007 -2012 Senior Statistical Analyst, • Supervising biostatisticians and senior biostatisticians in clinical trials, genetic studies and epidemiology studies • Developing new statistical methods for analyzing multicentre clinical trials • Developing genetic statistical methods and analyzing large genetic data • Analyzing and publishing the results of clinical trials • Preparing DSMB • Organizing regular statistical seminars , PHRI, Department of Medicine, McMaster University, Hamilton, Canada

2009 -2012 Assistant Professor, • Teaching in the Health Research Methodology Graduate Program • Teaching in the Population Genomics Program • Supervising Master/PhD students , Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

2012 -2015 Assistant Professor(tenure-track), • Teaching biostatistics courses • Supervising Master/PhD students • Statistical consulting (Clinical trials, epidemiology and genetic studies) • Reviewing grant proposals • DSMB member for Clinical trials • UC IRB Committee member • Protocol Review and Monitoring Committee member in UC Cancer Institute and UC Health , Department of Environmental Health, University of Cincinnati, Cincinnati, USA

2015 -2018 Associate Professor, • Teaching biostatistics courses • Supervising Master/PhD students • Statistical consulting (Clinical trials, epidemiology and genetic studies) • Reviewing grant proposals • DSMB member for Clinical trials • UC IRB Committee member • Protocol Review and Monitoring Committee member in UC Cancer Institute and UC Health , Department of Environmental Health, University of Cincinnati, Cincinnati, USA

2018 - Professor, • Co-PI/Co-I for multiple grants • Teaching biostatistics courses • Supervising Master/PhD students • Statistical consulting (Clinical trials, epidemiology and genetic studies) • Reviewing grant proposals • DSMB member for Clinical trials • UC IRB Committee member • Protocol Review and Monitoring Committee member in UC Cancer Institute and UC Health , Department of Environmental Health, University of Cincinnati, Cincinnati, USA

Research and Practice Interests

My research interests include
1) clinical trials,
2) statistical genetics: next generation sequencing, Genome-wide association study, NDA methylation, gene environmental interaction,
3) statistical methodology: survival  models, multiple testing, hierarchical generalized linear models, nonparametric methods, longitudinal data and multivariate statistical analysis.

Contact Information

Academic - Division of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati
104 Kettering Lab, 160 Panzeca Way
Cincinnati  Ohio, 45267
Phone: (513)-558-0229
xiecn@ucmail.uc.edu