Zhenyu Yuan

Zhenyu Yuan

Research Scientist

Research Associate- Kovall Lab



COM Mol Cell Kovall Lab - 0524


Peer Reviewed Publications

Collins, Kelly J; Yuan, Zhenyu; Kovall, Rhett A (2014. ) Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of notch signaling.Structure (London, England : 1993), , 22 (1 ) ,70-81 More Information

Yuan, Zhenyu; Friedmann, David R; VanderWielen, Bradley D; Collins, Kelly J; Kovall, Rhett A (2012. ) Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.The Journal of biological chemistry, , 287 (42 ) ,34904-16 More Information

Maier, Dieter; Kurth, Patricia; Schulz, Adriana; Russell, Andrew; Yuan, Zhenyu; Gruber, Kim; Kovall, Rhett A; Preiss, Anette (2011. ) Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster.Molecular biology of the cell, , 22 (17 ) ,3242-52 More Information

VanderWielen, Bradley D; Yuan, Zhenyu; Friedmann, David R; Kovall, Rhett A (2011. ) Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes.The Journal of biological chemistry, , 286 (17 ) ,14892-902 More Information

Bahassi, El Mustapha; Yin, Moying; Robbins, Susan B; Li, Ya-Qin; Conrady, Deborah G; Yuan, Zhenyu; Kovall, Rhett A; Herr, Andrew B; Stambrook, Peter J (2011. ) A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis.Cell division, , 6 (1 ) ,4 More Information

Chen, Zhuo; Zhang, Kun; Zhang, Xin; Yuan, Xiao H; Yuan, Zhenyu; Jin, Li; Xiong, Momiao (2003. ) Comparison of gene expression between metastatic derivatives and their poorly metastatic parental cells implicates crucial tumor-environment interaction in metastasis of head and neck squamous cell carcinoma. Clinical & experimental metastasis, , 20 (4 ) ,335-42

Contreras, Ashley N; Yuan, Zhenyu; Kovall, Rhett A (2015. ) Thermodynamic binding analysis of Notch transcription complexes from Drosophila melanogaster.Protein science : a publication of the Protein Society, , 24 (5 ) ,812-22 More Information

Tabaja, Nassif; Yuan, Zhenyu; Oswald, Franz; Kovall, Rhett A (2017. ) Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.The Journal of biological chemistry, , 292 (25 ) ,10549-10563 More Information

Yuan, Zhenyu; Praxenthaler, Heiko; Tabaja, Nassif; Torella, Rubben; Preiss, Anette; Maier, Dieter; Kovall, Rhett A (2016. ) Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster.PLoS biology, , 14 (7 ) ,e1002509 More Information

Gomez-Lamarca, Maria J; Falo-Sanjuan, Julia; Stojnic, Robert; Abdul Rehman, Sohaib; Muresan, Leila; Jones, Matthew L; Pillidge, Zoe; Cerda-Moya, Gustavo; Yuan, Zhenyu; Baloul, Sarah; Valenti, Phillippe; Bystricky, Kerstin; Payre, Francois; O'Holleran, Kevin; Kovall, Rhett; Bray, Sarah J (2018. ) Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics.Developmental cell, , 44 (5 ) ,611-623.e7 More Information

Nagel, Anja C; Auer, Jasmin S; Schulz, Adriana; Pfannstiel, Jens; Yuan, Zhenyu; Collins, Courtney E; Kovall, Rhett A; Preiss, Anette (2017. ) Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity.Scientific reports, , 7 (1 ) ,11820 More Information