Jane J Yu, PhD

Grant: #Cornell sub / HL121266 Investigators:Yu, Jane 07-01-2015 -12-31-2017 National Heart, Lung and Blood Institute Molecular and biochemical basis of Lymphangioleiomyomatosis Role:PI $32,704.00 Active Level:Federal

Grant: #R01DK098831 Investigators:Yu, Jane 07-01-2015 -06-30-2017 National Inst of Diabetes and Digestive and Kidney Disease Prostaglandin biosynthesis: a novel therapeutic target in TSC disorders Role:PI $237,000.00 Active Level:Federal

Grant: #LMA150021PR Investigators:Yu, Jane 07-01-2015 -12-31-2015 University of Pennsylvania Health System Evaluation of PLK1 inhibitors in a pre-clinical LAM animal model Role:PI $1,488.00 Active Level:Private Non-Profit

Grant: #R01 HL098216 Investigators:Yu, Jane 11-09-2015 -03-31-2016 National Heart, Lung and Blood Institute Targeting the Estrogen Pathway for the Prevention and Treatment of LAM Role:PI $178,743.83 Active Level:Federal

Grant: #LAM0124B07-17 Investigators:Yu, Jane 07-01-2017 -06-30-2018 Lymphangioleiomyomatosis Foundation (LAM) Targeting prostaglandin biosynthesis and action in lymphangioleiomyomatosis Role:PI $150,000.00 Active Level:Private Non-Profit

Grant: #R01 HL138481 Investigators:Gupta, Nishant; Ho, Shuk Mei; McCormack, Francis; Yu, Jane 08-01-2017 -06-30-2020 National Heart, Lung and Blood Institute Targeting prostaglandin biosynthesis and action in lymphangioleiomyomatosis Role:PI $651,071.00 Awarded Level:Federal

Grant: #R01 HL135122 Investigators:Borchers, Michael; McCormack, Francis; Yu, Jane 12-07-2017 -11-30-2021 National Heart, Lung and Blood Institute Pulmonary Epithelial Dynamics and Innate Host Defense Role:Collaborator $506,717.00 Active Level:Federal

Grant: #MDBR-18-119-LAM Investigators:Yu, Jane 01-01-2018 -12-31-2018 Lymphangioleiomyomatosis Foundation (LAM) The impact of estrogen-promoted extracellular matrix-degrading programs on LAM progression Role:PI $50,060.00 Awarded Level:Private Non-Profit

Grant: #LAM0133PB07-18 Investigators:Medvedovic, Mario; Yu, Jane 09-01-2018 -08-31-2019 Lymphangioleiomyomatosis Foundation (LAM) Single-Cell-RNA Sequencing for Identifying Differential Responses to Sirolimus Therapy in LAM Role:PI $10,000.00 Active Level:Private Non-Profit

Grant: #BSR-03-18 Investigators:; Yu, Jane 11-01-2018 -10-31-2019 Tuberous Sclerosis Alliance Quantification of plasma levels of sphingolipids and ceramides in patients with TSC. Role:PI $20,000.00 Awarded Level:Private Non-Profit

Grant: #LAM0141E01-20 Investigators:Yu, Jane 01-15-2020 -01-14-2023 Lymphangioleiomyomatosis Foundation (LAM) Role of homeobox genes in hormonal regulation of transcriptional activation in LAM progression Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #LAM0140C06-19 Investigators:Liu, xiaolei; Yu, Jane 07-01-2019 -01-14-2021 Lymphangioleiomyomatosis Foundation (LAM) Dysregulation of Sphingolipid Metabolism and Functions in Lymphangioleiomyomatosis Role:PI $37,500.00 Closed Level:Private Non-Profit

Grant: #W81XWH-20-1-0736 Investigators:McCormack, Francis; Soleimani, Manoocher; Yu, Jane 09-01-2020 -08-31-2023 Department of the Army Medical Research Acquisition Activity Dysregulation of sphingolipid metabolism and actions in tuberous sclerosis complex Role:PI $722,250.00 Awarded Level:Federal

Grant: #W81XWH1910474 Investigators:Medvedovic, Mario; Yu, Jane 07-15-2019 -07-14-2021 Department of the Army Medical Research Acquisition Activity TS180051 Development of remission-inducing therapy for TSC tumors Role:PI $160,500.00 Active Level:Federal

Grant: #CCHMC / R01HL153045 Investigators:McCormack, Francis; Yu, Jane 07-21-2020 -06-30-2024 National Heart, Lung and Blood Institute Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM). Role:PI $386,106.84 Active Level:Federal

Grant: #TTU / R01HL160972 Investigators:Yu, Jane 12-20-2021 -11-30-2025 National Heart, Lung and Blood Institute Investigate the role of extracellular vesicles in promoting the progression of pulmonary lymphangioleiomyomatosis Role:PI 718036.00 Hold Level:Federal

Grant: #OS00000518-316944 Investigators:Yu, Jane 01-15-2023 -01-14-2024 Cincinnati Children's Hospital Medical Center An Information Retrieval System for Multiomics Data Integration and LAM Biomarker Discovery Role:PI 0.00 Hold Level:Non Profit

Grant: #R56DK137834 Investigators:Astreinidis, Aristotelis; Yu, Jane 09-20-2023 -09-19-2024 National Inst of Diabetes and Digestive and Kidney Disease Polo-like kinase 1 and sphingosine-1-phosphate circuitry enhances TSC-mutant cell survival Role:PI 99999.00 Awarded Level:Federal

Peer Reviewed Publications

Li, Xiangke; Liu, Xiaolei; Zhang, Linda; Li, Chenggang; Zhang, Erik; Ma, Wang; Fan, Qingxia; Yu, Jane J (2017. ) Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis.Oncotarget, , 8 (22 ) ,36628-36638 More Information

Li, Na; Lu, Yanjuan; Li, Daoming; Zheng, Xiangyu; Lian, Jingyao; Li, Shanshan; Cui, Huijuan; Zhang, Linda; Sang, Luqian; Wang, Ying; Yu, Jane J; Lu, Taiying (2017. ) All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma.PloS one, , 12 (4 ) ,e0174555 More Information

Lam, Hilaire C; Baglini, Christian V; Lope, Alicia Llorente; Parkhitko, Andrey A; Liu, Heng-Jia; Alesi, Nicola; Malinowska, Izabela A; Ebrahimi-Fakhari, Darius; Saffari, Afshin; Yu, Jane J; Pereira, Ana; Khabibullin, Damir; Ogorek, Barbara; Nijmeh, Julie; Kavanagh, Taylor; Handen, Adam; Chan, Stephen Y; Asara, John M; Oldham, William M; Diaz-Meco, Maria T; Moscat, Jorge; Sahin, Mustafa; Priolo, Carmen; Henske, Elizabeth P (2017. ) p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.Cancer research, , 77 (12 ) ,3255-3267 More Information

Li, Chenggang; Li, Na; Liu, Xiaolei; Zhang, Erik Y; Sun, Yang; Masuda, Kouhei; Li, Jing; Sun, Julia; Morrison, Tasha; Li, Xiangke; Chen, Yuanguang; Wang, Jiang; Karim, Nagla A; Zhang, Yi; Blenis, John; Reginato, Mauricio J; Henske, Elizabeth P; Yu, Jane J (2016. ) Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.JCI insight, , 1 (19 ) ,e86629 More Information

Goldberg, Alexander A; Joung, Kwang-Bo; Mansuri, Asma; Kang, Yujin; Echavarria, Raquel; Nikolajev, Ljiljana; Sun, Yang; Yu, Jane J; Laporte, Stephane A; Schwertani, Adel; Kristof, Arnold S (2016. ) Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2.Oncotarget, , 7 (38 ) ,61152-61165 More Information

Li, Jing; Shin, Sejeong; Sun, Yang; Yoon, Sang-Oh; Li, Chenggang; Zhang, Erik; Yu, Jane; Zhang, Jianming; Blenis, John (2016. ) mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.Cancer research, , 76 (16 ) ,4816-27 More Information

Alayev, Anya; Salamon, Rachel S; Sun, Yang; Schwartz, Naomi S; Li, Chenggang; Yu, Jane J; Holz, Marina K (2015. ) Effects of combining rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors.American journal of respiratory cell and molecular biology, , 53 (5 ) ,637-46 More Information

Priolo, Carmen; Ricoult, Stéphane J H; Khabibullin, Damir; Filippakis, Harilaos; Yu, Jane; Manning, Brendan D; Clish, Clary; Henske, Elizabeth P (2015. ) Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology, , 53 (1 ) ,33-41 More Information

Li, Jing; Csibi, Alfredo; Yang, Sun; Hoffman, Gregory R; Li, Chenggang; Zhang, Erik; Yu, Jane J; Blenis, John (2015. ) Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.Proceedings of the National Academy of Sciences of the United States of America, , 112 (1 ) ,E21-9 More Information

Sun, Yang; Gallacchi, Dana; Zhang, Erik Y; Reynolds, Samuel B; Robinson, Lauren; Malinowska, Izabela A; Chiou, Terry T; Pereira, Ana M; Li, Chenggang; Kwiatkowski, David J; Lee, Po-Shun; Yu, Jane J (2014. ) Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology, , 51 (6 ) ,738-49 More Information

Li, Chenggang; Zhang, Erik; Sun, Yang; Lee, Po-Shun; Zhan, Yongzhong; Guo, Yanan; Osorio, Juan C; Rosas, Ivan O; Xu, Kai-Feng; Kwiatkowski, David J; Yu, Jane J (2014. ) Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.PloS one, , 9 (10 ) ,e104809 More Information

Sun, Yang; Zhang, Erik; Lao, Taotao; Pereira, Ana M; Li, Chenggang; Xiong, Li; Morrison, Tasha; Haley, Kathleen J; Zhou, Xiaobo; Yu, Jane J (2014. ) Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis.Hormones & cancer, , 5 (5 ) ,284-98 More Information

Sun, Y; Gu, X; Zhang, E; Park, M-A; Pereira, A M; Wang, S; Morrison, T; Li, C; Blenis, J; Gerbaudo, V H; Henske, E P; Yu, J J (2014. ) Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.Cell death & disease, , 5 ,e1231 More Information

Yu, Jane (2014. ) Reply: hormonally targeted therapy for women with lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology, , 50 (3 ) ,665 More Information

Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D; Kwiatkowski, David; Yu, Jane J (2014. ) Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.The Journal of experimental medicine, , 211 (1 ) ,15-28 More Information

Alayev, Anya; Sun, Yang; Snyder, Rose B; Berger, Sara Malka; Yu, Jane J; Holz, Marina K (2014. ) Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells.Cell cycle (Georgetown, Tex.), , 13 (3 ) ,371-82 More Information

Gu, Xiaoxiao; Yu, Jane J; Ilter, Didem; Blenis, Nickolas; Henske, Elizabeth Petri; Blenis, John (2013. ) Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.Proceedings of the National Academy of Sciences of the United States of America, , 110 (37 ) ,14960-5 More Information

Li, Chenggang; Zhou, Xiaobo; Sun, Yang; Zhang, Erik; Mancini, John D; Parkhitko, Andrey; Morrison, Tasha A; Silverman, Edwin K; Henske, Elizabeth P; Yu, Jane J (2013. ) Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology, , 49 (1 ) ,135-42 More Information

Trindade, Anil J; Medvetz, Douglas A; Neuman, Nicole A; Myachina, Faina; Yu, Jane; Priolo, Carmen; Henske, Elizabeth P (2013. ) MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM).PloS one, , 8 (3 ) ,e60014 More Information

Liu, Fangbing; Lunsford, Elaine P; Tong, Jingli; Ashitate, Yoshitomo; Gibbs, Summer L; Yu, Jane; Choi, Hak Soo; Henske, Elizabeth P; Frangioni, John V (2012. ) Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex.PloS one, , 7 (6 ) ,e38589 More Information

Yu, Jane; Parkhitko, Andrey; Henske, Elizabeth Petri (2011. ) Autophagy: an 'Achilles' heel of tumorigenesis in TSC and LAM.Autophagy, , 7 (11 ) ,1400-1 More Information

Yu, Jane; Henske, Elizabeth Petri (2010. ) mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis.Lymphatic research and biology, , 8 (1 ) ,43-9 More Information

Yu, Jane; Parkhitko, Andrey A; Henske, Elizabeth Petri (2010. ) Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy.Proceedings of the American Thoracic Society, , 7 (1 ) ,48-53 More Information

Yu, Jane J; Robb, Victoria A; Morrison, Tasha A; Ariazi, Eric A; Karbowniczek, Magdalena; Astrinidis, Aristotelis; Wang, Chunrong; Hernandez-Cuebas, Lisa; Seeholzer, Laura F; Nicolas, Emmanuelle; Hensley, Harvey; Jordan, V Craig; Walker, Cheryl L; Henske, Elizabeth P (2009. ) Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells.Proceedings of the National Academy of Sciences of the United States of America, , 106 (8 ) ,2635-40 More Information

Yu, Jane; Astrinidis, Aristotelis; Howard, Sharon; Henske, Elizabeth Petri (2004. ) Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways.American journal of physiology. Lung cellular and molecular physiology, , 286 (4 ) ,L694-700 More Information

Lv, Zhuan; Yu, Jane J; Zhang, Wei-Jie; Xiong, Li; Wang, Feng; Li, Li-Feng; Zhou, Xue-Liang; Gao, Xin-Ya; Ding, Xian-Fei; Han, Li; Cai, Ya-Fei; Ma, Wang; Wang, Liu-Xing (2017. ) Expression and functional regulation of stemness gene Lgr5 in esophageal squamous cell carcinoma.Oncotarget, , 8 (16 ) ,26492-26504 More Information

Jiang, Zhiqiang; Lao, Taotao; Qiu, Weiliang; Polverino, Francesca; Gupta, Kushagra; Guo, Feng; Mancini, John D; Naing, Zun Zar Chi; Cho, Michael H; Castaldi, Peter J; Sun, Yang; Yu, Jane; Laucho-Contreras, Maria E; Kobzik, Lester; Raby, Benjamin A; Choi, Augustine M K; Perrella, Mark A; Owen, Caroline A; Silverman, Edwin K; Zhou, Xiaobo (2016. ) A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ?-Catenin.American journal of respiratory and critical care medicine, , 194 (2 ) ,185-97 More Information

He, Jing; Zhou, Mingxia; Chen, Xinfeng; Yue, Dongli; Yang, Li; Qin, Guohui; Zhang, Zhen; Gao, Qun; Wang, Dan; Zhang, Chaoqi; Huang, Lan; Wang, Liping; Zhang, Bin; Yu, Jane; Zhang, Yi (2016. ) Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/?-catenin pathway in esophageal squamous cell carcinoma.Journal of experimental & clinical cancer research : CR, , 35 (1 ) ,98 More Information

Gu, Hongjing; Xie, Zhengde; Li, Tieling; Zhang, Shaogeng; Lai, Chengcai; Zhu, Ping; Wang, Keyu; Han, Lina; Duan, Yueqiang; Zhao, Zhongpeng; Yang, Xiaolan; Xing, Li; Zhang, Peirui; Wang, Zhouhai; Li, Ruisheng; Yu, Jane J; Wang, Xiliang; Yang, Penghui (2016. ) Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus.Scientific reports, , 6 ,19840 More Information

Medvetz, Doug; Sun, Yang; Li, Chenggang; Khabibullin, Damir; Balan, Murugabaskar; Parkhitko, Andrey; Priolo, Carmen; Asara, John M; Pal, Soumitro; Yu, Jane; Henske, Elizabeth P (2015. ) High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.Molecular cancer research : MCR, , 13 (1 ) ,50-62 More Information

Khabibullin, Damir; Medvetz, Douglas A; Pinilla, Miguel; Hariharan, Venkatesh; Li, Chenggang; Hergrueter, Anja; Laucho Contreras, Maria; Zhang, Erik; Parkhitko, Andrey; Yu, Jane J; Owen, Caroline A; Huang, Hayden; Baron, Rebecca M; Henske, Elizabeth P (2014. ) Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells.Physiological reports, , 2 (8 ) , More Information

Yang, Ping; Cornejo, Kristine M; Sadow, Peter M; Cheng, Liang; Wang, Mingsheng; Xiao, Yu; Jiang, Zhong; Oliva, Esther; Jozwiak, Sergiusz; Nussbaum, Robert L; Feldman, Adam S; Paul, Elahna; Thiele, Elizabeth A; Yu, Jane J; Henske, Elizabeth P; Kwiatkowski, David J; Young, Robert H; Wu, Chin-Lee (2014. ) Renal cell carcinoma in tuberous sclerosis complex.The American journal of surgical pathology, , 38 (7 ) ,895-909 More Information

Parkhitko, Andrey A; Priolo, Carmen; Coloff, Jonathan L; Yun, Jihye; Wu, Julia J; Mizumura, Kenji; Xu, Wenping; Malinowska, Izabela A; Yu, Jane; Kwiatkowski, David J; Locasale, Jason W; Asara, John M; Choi, Augustine M K; Finkel, Toren; Henske, Elizabeth P (2014. ) Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.Molecular cancer research : MCR, , 12 (1 ) ,48-57 More Information

Csibi, Alfred; Fendt, Sarah-Maria; Li, Chenggang; Poulogiannis, George; Choo, Andrew Y; Chapski, Douglas J; Jeong, Seung Min; Dempsey, Jamie M; Parkhitko, Andrey; Morrison, Tasha; Henske, Elizabeth P; Haigis, Marcia C; Cantley, Lewis C; Stephanopoulos, Gregory; Yu, Jane; Blenis, John (2013. ) The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.Cell, , 153 (4 ) ,840-54 More Information

Yu, Jane; Henske, Elizabeth Petri (2011. ) TORC1 activation and autophagy inhibition: opposing forces in Rheb-driven tumorigenesis.Cell cycle (Georgetown, Tex.), , 10 (22 ) ,3803-4 More Information

Karbowniczek, Magdalena; Zitserman, Diana; Khabibullin, Damir; Hartman, Tiffiney; Yu, Jane; Morrison, Tasha; Nicolas, Emmanuelle; Squillace, Rachel; Roegiers, Fabrice; Henske, Elizabeth Petri (2010. ) The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.The Journal of clinical investigation, , 120 (1 ) ,93-102 More Information

Li, Faqiang; Vallabhaneni, Ratnakar; Yu, Jane; Rocheford, Torbert; Wurtzel, Eleanore T (2008. ) The maize phytoene synthase gene family: overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance.Plant physiology, , 147 (3 ) ,1334-46 More Information

Yu, Jane; Henske, Elizabeth Petri (2006. ) Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.Cancer research, , 66 (19 ) ,9461-6 More Information

Karbowniczek, Magdalena; Yu, Jane; Henske, Elizabeth Petri (2003. ) Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures.The American journal of pathology, , 162 (2 ) ,491-500 More Information

Yu, J; Astrinidis, A; Henske, E P (2001. ) Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis.American journal of respiratory and critical care medicine, , 164 (8 Pt 1 ) ,1537-40 More Information

Qun Gao; Shumin Wang; Xinfeng Chen; Shaoyan Cheng; Zhen Zhang; Feng Li; Lan Huang; Yang Yang; Bin Zhou; Dongli Yue; Dan Wang; Ling Cao; Nomathamsanqa Resegofetse Maimela; Bin Zhang; Jane Yu; Liping Wang; Yi Zhang. (2019. ) Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC .J ImmunoTherapy of Cancer, ,

Matthildi Valianou, Natalia Filippidou, Daniel L. Johnson, Peter Vogel, Erik Y. Zhang, Xiaolei Liu, Yiyang Lu, Jane J. Yu, John J. Bissler, Aristotelis Astrinidis. (2019. ) Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells .Sci Reports, ,

Wang Ma, Shuangyuan Wang, Tengfei Zhang, Erik Y. Zhang, Lina Zhou, Chunxiu Hu, Jane J. Yu* and Guowang Xu* (2018. ) Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas. J Pharm Biomedical Anal, , 155 ,148

Hsieh, Hui-Ju; Zhang, Wei; Lin, Shu-Hong; Yang, Wen-Hao; Wang, Jun-Zhong; Shen, Jianfeng; Zhang, Yiran; Lu, Yiling; Wang, Hua; Yu, Jane; Mills, Gordon B; Peng, Guang (2018. ) Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery.Nature communications, , 9 (1 ) ,3982 More Information

Li, Lifeng; Wang, Liping; Li, Jieyao; Fan, Zhirui; Yang, Li; Zhang, Zhen; Zhang, Chaoqi; Yue, Dongli; Qin, Guohui; Zhang, Tengfei; Li, Feng; Chen, Xinfeng; Ping, Yu; Wang, Dan; Gao, Qun; He, Qianyi; Huang, Lan; Li, Hong; Huang, Jianmin; Zhao, Xuan; Xue, Wenhua; Sun, Zhi; Lu, Jingli; Yu, Jane J; Zhao, Jie; Zhang, Bin; Zhang, Yi (2018. ) Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer.Cancer research, , 78 (7 ) ,1779-1791 More Information

Tang, Ling; Zeng, Jun; Geng, Pengyu; Fang, Chengnan; Wang, Yang; Sun, Mingju; Wang, Changsong; Wang, Jiao; Yin, Peiyuan; Hu, Chunxiu; Guo, Lei; Yu, Jane; Gao, Peng; Li, Enyou; Zhuang, Zhengping; Xu, Guowang; Liu, Yang (2018. ) Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research, , 24 (2 ) ,474-485 More Information

Shao, Yaping; Ye, Guozhu; Ren, Shancheng; Piao, Hai-Long; Zhao, Xinjie; Lu, Xin; Wang, Fubo; Ma, Wang; Li, Jia; Yin, Peiyuan; Xia, Tian; Xu, Chuanliang; Yu, Jane J; Sun, Yinghao; Xu, Guowang (2018. ) Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer.International journal of cancer, , 143 (2 ) ,396-407 More Information

Lee, Gina; Zheng, Yuxiang; Cho, Sungyun; Jang, Cholsoon; England, Christina; Dempsey, Jamie M; Yu, Yonghao; Liu, Xiaolei; He, Long; Cavaliere, Paola M; Chavez, Andre; Zhang, Erik; Isik, Meltem; Couvillon, Anthony; Dephoure, Noah E; Blackwell, T Keith; Yu, Jane J; Rabinowitz, Joshua D; Cantley, Lewis C; Blenis, John (2017. ) Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.Cell, , 171 (7 ) ,1545-1558.e18 More Information

Qiao, Y; Zhang, C; Li, A; Wang, D; Luo, Z; Ping, Y; Zhou, B; Liu, S; Li, H; Yue, D; Zhang, Z; Chen, X; Shen, Z; Lian, J; Li, Y; Wang, S; Li, F; Huang, L; Wang, L; Zhang, B; Yu, J; Qin, Z; Zhang, Y (2018. ) IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma.Oncogene, , 37 (7 ) ,873-883 More Information

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J (2017. ) Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.Molecular cancer research : MCR, , 15 (10 ) ,1318-1330 More Information

Xiaolei Liu , Erik Zhang , Kopras Elizabeth J. , Eric Smith , Yiyang Lu , Aristoteli Astreinidis , Yuet-Kin Leung , Shuk-Mei Ho , Maciej Markiewski , MAGDALENA KARBOWNICZEK , Manoocher Soleimani , Chenggang Li, and Jane J. YU (2019. ) mTORC1 and estrogen cooperate to induce pyruvate kinase M2 phosphorylation and increase the survival of TSC2-deficient cells .Oncogenesis, ,

Jiange Qiu, Qianqian Li, Katherine A. Bell, Xue Yao, Erik Zhang, Jane J. Yu, Zhi Shi, and Jianxiong Jiang (2019. ) Small-molecule inhibition of prostaglandin receptor EP2 impairs cyclooxygenase-associated malignant glioma growth .British Journal of Pharmacology , ,