Jane J Yu, PhD

Grant: #Cornell sub / HL121266 Investigators:Yu, Jane 07-01-2015 -12-31-2017 National Heart, Lung and Blood Institute Molecular and biochemical basis of Lymphangioleiomyomatosis Role:PI $32,704.00 Active Level:Federal

Grant: #R01DK098831 Investigators:Yu, Jane 07-01-2015 -06-30-2017 National Inst of Diabetes and Digestive and Kidney Disease Prostaglandin biosynthesis: a novel therapeutic target in TSC disorders Role:PI $237,000.00 Active Level:Federal

Grant: #LMA150021PR Investigators:Yu, Jane 07-01-2015 -12-31-2015 University of Pennsylvania Health System Evaluation of PLK1 inhibitors in a pre-clinical LAM animal model Role:PI $1,488.00 Active Level:Private Non-Profit

Grant: #R01 HL098216 Investigators:Yu, Jane 11-09-2015 -03-31-2016 National Heart, Lung and Blood Institute Targeting the Estrogen Pathway for the Prevention and Treatment of LAM Role:PI $178,743.83 Active Level:Federal

Grant: #LAM0124B07-17 Investigators:Yu, Jane 07-01-2017 -06-30-2018 Lymphangioleiomyomatosis Foundation (LAM) Targeting prostaglandin biosynthesis and action in lymphangioleiomyomatosis Role:PI $150,000.00 Active Level:Private Non-Profit

Grant: #R01 HL138481 Investigators:Gupta, Nishant; Ho, Shuk Mei; McCormack, Francis; Yu, Jane 08-01-2017 -06-30-2020 National Heart, Lung and Blood Institute Targeting prostaglandin biosynthesis and action in lymphangioleiomyomatosis Role:PI $651,071.00 Awarded Level:Federal

Grant: #R01 HL135122 Investigators:Borchers, Michael; McCormack, Francis; Yu, Jane 12-07-2017 -11-30-2021 National Heart, Lung and Blood Institute Pulmonary Epithelial Dynamics and Innate Host Defense Role:Collaborator $506,717.00 Active Level:Federal

Grant: #MDBR-18-119-LAM Investigators:Yu, Jane 01-01-2018 -12-31-2018 Lymphangioleiomyomatosis Foundation (LAM) The impact of estrogen-promoted extracellular matrix-degrading programs on LAM progression Role:PI $50,060.00 Awarded Level:Private Non-Profit

Grant: #LAM0133PB07-18 Investigators:Medvedovic, Mario; Yu, Jane 09-01-2018 -08-31-2019 Lymphangioleiomyomatosis Foundation (LAM) Single-Cell-RNA Sequencing for Identifying Differential Responses to Sirolimus Therapy in LAM Role:PI $10,000.00 Active Level:Private Non-Profit

Grant: #BSR-03-18 Investigators:; Yu, Jane 11-01-2018 -10-31-2019 Tuberous Sclerosis Alliance Quantification of plasma levels of sphingolipids and ceramides in patients with TSC. Role:PI $20,000.00 Awarded Level:Private Non-Profit

Grant: #LAM0141E01-20 Investigators:Yu, Jane 01-15-2020 -01-14-2023 Lymphangioleiomyomatosis Foundation (LAM) Role of homeobox genes in hormonal regulation of transcriptional activation in LAM progression Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #LAM0140C06-19 Investigators:Liu, xiaolei; Yu, Jane 07-01-2019 -01-14-2021 Lymphangioleiomyomatosis Foundation (LAM) Dysregulation of Sphingolipid Metabolism and Functions in Lymphangioleiomyomatosis Role:PI $37,500.00 Closed Level:Private Non-Profit

Grant: #W81XWH-20-1-0736 Investigators:McCormack, Francis; Soleimani, Manoocher; Yu, Jane 09-01-2020 -08-31-2023 Department of the Army Medical Research Acquisition Activity Dysregulation of sphingolipid metabolism and actions in tuberous sclerosis complex Role:PI $722,250.00 Awarded Level:Federal

Grant: #W81XWH1910474 Investigators:Medvedovic, Mario; Yu, Jane 07-15-2019 -07-14-2021 Department of the Army Medical Research Acquisition Activity TS180051 Development of remission-inducing therapy for TSC tumors Role:PI $160,500.00 Active Level:Federal

Grant: #CCHMC / R01HL153045 Investigators:McCormack, Francis; Yu, Jane 07-21-2020 -06-30-2024 National Heart, Lung and Blood Institute Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM). Role:PI $386,106.84 Active Level:Federal

Grant: #TTU / R01HL160972 Investigators:Yu, Jane 12-20-2021 -11-30-2025 National Heart, Lung and Blood Institute Investigate the role of extracellular vesicles in promoting the progression of pulmonary lymphangioleiomyomatosis Role:PI 718036.00 Hold Level:Federal

Grant: #OS00000518-316944 Investigators:Yu, Jane 01-15-2023 -01-14-2024 Cincinnati Children's Hospital Medical Center An Information Retrieval System for Multiomics Data Integration and LAM Biomarker Discovery Role:PI 0.00 Hold Level:Non Profit

Grant: #R56DK137834 Investigators:Astreinidis, Aristotelis; Yu, Jane 09-20-2023 -09-19-2024 National Inst of Diabetes and Digestive and Kidney Disease Polo-like kinase 1 and sphingosine-1-phosphate circuitry enhances TSC-mutant cell survival Role:PI 99999.00 Awarded Level:Federal

Grant: #R01HL172914 Investigators:Gupta, Nishant; Yu, Jane 02-01-2025 -11-30-2028 Cincinnati Children's Hospital Medical Center Cellular determinants of responsiveness to mTOR inhibitors in LAM Role:PI 364469.00 Hold Level:Non Profit

Grant: #LAM0164E01-1177076-24 Investigators:Yu, Jane 01-15-2025 -01-14-2026 Cincinnati Children's Hospital Medical Center Identifying Cell-Cell Signaling Driving Pulmonary LAM Pathogenesis Using Spatial Omics Strategies Role:PI 13888.00 Hold Level:Non Profit

Grant: #R01HL178848 Investigators:Davidson, Sean; Gupta, Nishant; Shi, Wei; Yu, Jane 04-01-2025 -03-31-2030 National Heart, Lung and Blood Institute Dysregulation of sphingolipid metabolism and signaling in LAM Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Li, Xiangke; Liu, Xiaolei; Zhang, Linda; Li, Chenggang; Zhang, Erik; Ma, Wang; Fan, Qingxia; Yu, Jane J  (2017). Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis. Oncotarget, 8 (22) , 36628-36638More Information

Li, Na; Lu, Yanjuan; Li, Daoming; Zheng, Xiangyu; Lian, Jingyao; Li, Shanshan; Cui, Huijuan; Zhang, Linda; Sang, Luqian; Wang, Ying; Yu, Jane J; Lu, Taiying  (2017). All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma. PloS one, 12 (4) , e0174555More Information

Lam, Hilaire C; Baglini, Christian V; Lope, Alicia Llorente; Parkhitko, Andrey A; Liu, Heng-Jia; Alesi, Nicola; Malinowska, Izabela A; Ebrahimi-Fakhari, Darius; Saffari, Afshin; Yu, Jane J; Pereira, Ana; Khabibullin, Damir; Ogorek, Barbara; Nijmeh, Julie; Kavanagh, Taylor; Handen, Adam; Chan, Stephen Y; Asara, John M; Oldham, William M; Diaz-Meco, Maria T; Moscat, Jorge; Sahin, Mustafa; Priolo, Carmen; Henske, Elizabeth P  (2017). p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer research, 77 (12) , 3255-3267More Information

Li, Chenggang; Li, Na; Liu, Xiaolei; Zhang, Erik Y; Sun, Yang; Masuda, Kouhei; Li, Jing; Sun, Julia; Morrison, Tasha; Li, Xiangke; Chen, Yuanguang; Wang, Jiang; Karim, Nagla A; Zhang, Yi; Blenis, John; Reginato, Mauricio J; Henske, Elizabeth P; Yu, Jane J  (2016). Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis. JCI insight, 1 (19) , e86629More Information

Goldberg, Alexander A; Joung, Kwang-Bo; Mansuri, Asma; Kang, Yujin; Echavarria, Raquel; Nikolajev, Ljiljana; Sun, Yang; Yu, Jane J; Laporte, Stephane A; Schwertani, Adel; Kristof, Arnold S  (2016). Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2. Oncotarget, 7 (38) , 61152-61165More Information

Li, Jing; Shin, Sejeong; Sun, Yang; Yoon, Sang-Oh; Li, Chenggang; Zhang, Erik; Yu, Jane; Zhang, Jianming; Blenis, John  (2016). mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress. Cancer research, 76 (16) , 4816-27More Information

Alayev, Anya; Salamon, Rachel S; Sun, Yang; Schwartz, Naomi S; Li, Chenggang; Yu, Jane J; Holz, Marina K  (2015). Effects of combining rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors. American journal of respiratory cell and molecular biology, 53 (5) , 637-46More Information

Priolo, Carmen; Ricoult, Stéphane J H; Khabibullin, Damir; Filippakis, Harilaos; Yu, Jane; Manning, Brendan D; Clish, Clary; Henske, Elizabeth P  (2015). Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 53 (1) , 33-41More Information

Li, Jing; Csibi, Alfredo; Yang, Sun; Hoffman, Gregory R; Li, Chenggang; Zhang, Erik; Yu, Jane J; Blenis, John  (2015). Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 112 (1) , E21-9More Information

Sun, Yang; Gallacchi, Dana; Zhang, Erik Y; Reynolds, Samuel B; Robinson, Lauren; Malinowska, Izabela A; Chiou, Terry T; Pereira, Ana M; Li, Chenggang; Kwiatkowski, David J; Lee, Po-Shun; Yu, Jane J  (2014). Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 51 (6) , 738-49More Information

Li, Chenggang; Zhang, Erik; Sun, Yang; Lee, Po-Shun; Zhan, Yongzhong; Guo, Yanan; Osorio, Juan C; Rosas, Ivan O; Xu, Kai-Feng; Kwiatkowski, David J; Yu, Jane J  (2014). Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. PloS one, 9 (10) , e104809More Information

Sun, Yang; Zhang, Erik; Lao, Taotao; Pereira, Ana M; Li, Chenggang; Xiong, Li; Morrison, Tasha; Haley, Kathleen J; Zhou, Xiaobo; Yu, Jane J  (2014). Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis. Hormones & cancer, 5 (5) , 284-98More Information

Sun, Y; Gu, X; Zhang, E; Park, M-A; Pereira, A M; Wang, S; Morrison, T; Li, C; Blenis, J; Gerbaudo, V H; Henske, E P; Yu, J J  (2014). Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells. Cell death & disease, 5, e1231More Information

Yu, Jane  (2014). Reply: hormonally targeted therapy for women with lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 50 (3) , 665More Information

Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D; Kwiatkowski, David; Yu, Jane J  (2014). Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. The Journal of experimental medicine, 211 (1) , 15-28More Information

Alayev, Anya; Sun, Yang; Snyder, Rose B; Berger, Sara Malka; Yu, Jane J; Holz, Marina K  (2014). Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells. Cell cycle (Georgetown, Tex.), 13 (3) , 371-82More Information

Gu, Xiaoxiao; Yu, Jane J; Ilter, Didem; Blenis, Nickolas; Henske, Elizabeth Petri; Blenis, John  (2013). Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110 (37) , 14960-5More Information

Li, Chenggang; Zhou, Xiaobo; Sun, Yang; Zhang, Erik; Mancini, John D; Parkhitko, Andrey; Morrison, Tasha A; Silverman, Edwin K; Henske, Elizabeth P; Yu, Jane J  (2013). Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 49 (1) , 135-42More Information

Trindade, Anil J; Medvetz, Douglas A; Neuman, Nicole A; Myachina, Faina; Yu, Jane; Priolo, Carmen; Henske, Elizabeth P  (2013). MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM). PloS one, 8 (3) , e60014More Information

Liu, Fangbing; Lunsford, Elaine P; Tong, Jingli; Ashitate, Yoshitomo; Gibbs, Summer L; Yu, Jane; Choi, Hak Soo; Henske, Elizabeth P; Frangioni, John V  (2012). Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PloS one, 7 (6) , e38589More Information

Yu, Jane; Parkhitko, Andrey; Henske, Elizabeth Petri  (2011). Autophagy: an 'Achilles' heel of tumorigenesis in TSC and LAM. Autophagy, 7 (11) , 1400-1More Information

Yu, Jane; Henske, Elizabeth Petri  (2010). mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis. Lymphatic research and biology, 8 (1) , 43-9More Information

Yu, Jane; Parkhitko, Andrey A; Henske, Elizabeth Petri  (2010). Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy. Proceedings of the American Thoracic Society, 7 (1) , 48-53More Information

Yu, Jane J; Robb, Victoria A; Morrison, Tasha A; Ariazi, Eric A; Karbowniczek, Magdalena; Astrinidis, Aristotelis; Wang, Chunrong; Hernandez-Cuebas, Lisa; Seeholzer, Laura F; Nicolas, Emmanuelle; Hensley, Harvey; Jordan, V Craig; Walker, Cheryl L; Henske, Elizabeth P  (2009). Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proceedings of the National Academy of Sciences of the United States of America, 106 (8) , 2635-40More Information

Yu, Jane; Astrinidis, Aristotelis; Howard, Sharon; Henske, Elizabeth Petri  (2004). Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways. American journal of physiology. Lung cellular and molecular physiology, 286 (4) , L694-700More Information

Lv, Zhuan; Yu, Jane J; Zhang, Wei-Jie; Xiong, Li; Wang, Feng; Li, Li-Feng; Zhou, Xue-Liang; Gao, Xin-Ya; Ding, Xian-Fei; Han, Li; Cai, Ya-Fei; Ma, Wang; Wang, Liu-Xing  (2017). Expression and functional regulation of stemness gene Lgr5 in esophageal squamous cell carcinoma. Oncotarget, 8 (16) , 26492-26504More Information

Jiang, Zhiqiang; Lao, Taotao; Qiu, Weiliang; Polverino, Francesca; Gupta, Kushagra; Guo, Feng; Mancini, John D; Naing, Zun Zar Chi; Cho, Michael H; Castaldi, Peter J; Sun, Yang; Yu, Jane; Laucho-Contreras, Maria E; Kobzik, Lester; Raby, Benjamin A; Choi, Augustine M K; Perrella, Mark A; Owen, Caroline A; Silverman, Edwin K; Zhou, Xiaobo  (2016). A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ?-Catenin. American journal of respiratory and critical care medicine, 194 (2) , 185-97More Information

He, Jing; Zhou, Mingxia; Chen, Xinfeng; Yue, Dongli; Yang, Li; Qin, Guohui; Zhang, Zhen; Gao, Qun; Wang, Dan; Zhang, Chaoqi; Huang, Lan; Wang, Liping; Zhang, Bin; Yu, Jane; Zhang, Yi  (2016). Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/?-catenin pathway in esophageal squamous cell carcinoma. Journal of experimental & clinical cancer research : CR, 35 (1) , 98More Information

Gu, Hongjing; Xie, Zhengde; Li, Tieling; Zhang, Shaogeng; Lai, Chengcai; Zhu, Ping; Wang, Keyu; Han, Lina; Duan, Yueqiang; Zhao, Zhongpeng; Yang, Xiaolan; Xing, Li; Zhang, Peirui; Wang, Zhouhai; Li, Ruisheng; Yu, Jane J; Wang, Xiliang; Yang, Penghui  (2016). Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Scientific reports, 6, 19840More Information

Medvetz, Doug; Sun, Yang; Li, Chenggang; Khabibullin, Damir; Balan, Murugabaskar; Parkhitko, Andrey; Priolo, Carmen; Asara, John M; Pal, Soumitro; Yu, Jane; Henske, Elizabeth P  (2015). High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting. Molecular cancer research : MCR, 13 (1) , 50-62More Information

Khabibullin, Damir; Medvetz, Douglas A; Pinilla, Miguel; Hariharan, Venkatesh; Li, Chenggang; Hergrueter, Anja; Laucho Contreras, Maria; Zhang, Erik; Parkhitko, Andrey; Yu, Jane J; Owen, Caroline A; Huang, Hayden; Baron, Rebecca M; Henske, Elizabeth P  (2014). Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells. Physiological reports, 2 (8) More Information

Yang, Ping; Cornejo, Kristine M; Sadow, Peter M; Cheng, Liang; Wang, Mingsheng; Xiao, Yu; Jiang, Zhong; Oliva, Esther; Jozwiak, Sergiusz; Nussbaum, Robert L; Feldman, Adam S; Paul, Elahna; Thiele, Elizabeth A; Yu, Jane J; Henske, Elizabeth P; Kwiatkowski, David J; Young, Robert H; Wu, Chin-Lee  (2014). Renal cell carcinoma in tuberous sclerosis complex. The American journal of surgical pathology, 38 (7) , 895-909More Information

Parkhitko, Andrey A; Priolo, Carmen; Coloff, Jonathan L; Yun, Jihye; Wu, Julia J; Mizumura, Kenji; Xu, Wenping; Malinowska, Izabela A; Yu, Jane; Kwiatkowski, David J; Locasale, Jason W; Asara, John M; Choi, Augustine M K; Finkel, Toren; Henske, Elizabeth P  (2014). Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Molecular cancer research : MCR, 12 (1) , 48-57More Information

Csibi, Alfred; Fendt, Sarah-Maria; Li, Chenggang; Poulogiannis, George; Choo, Andrew Y; Chapski, Douglas J; Jeong, Seung Min; Dempsey, Jamie M; Parkhitko, Andrey; Morrison, Tasha; Henske, Elizabeth P; Haigis, Marcia C; Cantley, Lewis C; Stephanopoulos, Gregory; Yu, Jane; Blenis, John  (2013). The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell, 153 (4) , 840-54More Information

Yu, Jane; Henske, Elizabeth Petri  (2011). TORC1 activation and autophagy inhibition: opposing forces in Rheb-driven tumorigenesis. Cell cycle (Georgetown, Tex.), 10 (22) , 3803-4More Information

Karbowniczek, Magdalena; Zitserman, Diana; Khabibullin, Damir; Hartman, Tiffiney; Yu, Jane; Morrison, Tasha; Nicolas, Emmanuelle; Squillace, Rachel; Roegiers, Fabrice; Henske, Elizabeth Petri  (2010). The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. The Journal of clinical investigation, 120 (1) , 93-102More Information

Li, Faqiang; Vallabhaneni, Ratnakar; Yu, Jane; Rocheford, Torbert; Wurtzel, Eleanore T  (2008). The maize phytoene synthase gene family: overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant physiology, 147 (3) , 1334-46More Information

Yu, Jane; Henske, Elizabeth Petri  (2006). Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain. Cancer research, 66 (19) , 9461-6More Information

Karbowniczek, Magdalena; Yu, Jane; Henske, Elizabeth Petri  (2003). Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures. The American journal of pathology, 162 (2) , 491-500More Information

Yu, J; Astrinidis, A; Henske, E P  (2001). Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. American journal of respiratory and critical care medicine, 164 (8 Pt 1) , 1537-40More Information

Qun Gao; Shumin Wang; Xinfeng Chen; Shaoyan Cheng; Zhen Zhang; Feng Li; Lan Huang; Yang Yang; Bin Zhou; Dongli Yue; Dan Wang; Ling Cao; Nomathamsanqa Resegofetse Maimela; Bin Zhang; Jane Yu; Liping Wang; Yi Zhang.  (2019). Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC. J ImmunoTherapy of Cancer

Matthildi Valianou, Natalia Filippidou, Daniel L. Johnson, Peter Vogel, Erik Y. Zhang, Xiaolei Liu, Yiyang Lu, Jane J. Yu, John J. Bissler, Aristotelis Astrinidis.  (2019). Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells. Sci Reports

Wang Ma, Shuangyuan Wang, Tengfei Zhang, Erik Y. Zhang, Lina Zhou, Chunxiu Hu, Jane J. Yu* and Guowang Xu*  (2018). Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas. J Pharm Biomedical Anal, 155, 148

Hsieh, Hui-Ju; Zhang, Wei; Lin, Shu-Hong; Yang, Wen-Hao; Wang, Jun-Zhong; Shen, Jianfeng; Zhang, Yiran; Lu, Yiling; Wang, Hua; Yu, Jane; Mills, Gordon B; Peng, Guang  (2018). Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery. Nature communications, 9 (1) , 3982More Information

Li, Lifeng; Wang, Liping; Li, Jieyao; Fan, Zhirui; Yang, Li; Zhang, Zhen; Zhang, Chaoqi; Yue, Dongli; Qin, Guohui; Zhang, Tengfei; Li, Feng; Chen, Xinfeng; Ping, Yu; Wang, Dan; Gao, Qun; He, Qianyi; Huang, Lan; Li, Hong; Huang, Jianmin; Zhao, Xuan; Xue, Wenhua; Sun, Zhi; Lu, Jingli; Yu, Jane J; Zhao, Jie; Zhang, Bin; Zhang, Yi  (2018). Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer. Cancer research, 78 (7) , 1779-1791More Information

Tang, Ling; Zeng, Jun; Geng, Pengyu; Fang, Chengnan; Wang, Yang; Sun, Mingju; Wang, Changsong; Wang, Jiao; Yin, Peiyuan; Hu, Chunxiu; Guo, Lei; Yu, Jane; Gao, Peng; Li, Enyou; Zhuang, Zhengping; Xu, Guowang; Liu, Yang  (2018). Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 24 (2) , 474-485More Information

Shao, Yaping; Ye, Guozhu; Ren, Shancheng; Piao, Hai-Long; Zhao, Xinjie; Lu, Xin; Wang, Fubo; Ma, Wang; Li, Jia; Yin, Peiyuan; Xia, Tian; Xu, Chuanliang; Yu, Jane J; Sun, Yinghao; Xu, Guowang  (2018). Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer. International journal of cancer, 143 (2) , 396-407More Information

Lee, Gina; Zheng, Yuxiang; Cho, Sungyun; Jang, Cholsoon; England, Christina; Dempsey, Jamie M; Yu, Yonghao; Liu, Xiaolei; He, Long; Cavaliere, Paola M; Chavez, Andre; Zhang, Erik; Isik, Meltem; Couvillon, Anthony; Dephoure, Noah E; Blackwell, T Keith; Yu, Jane J; Rabinowitz, Joshua D; Cantley, Lewis C; Blenis, John  (2017). Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell, 171 (7) , 1545-1558.e18More Information

Qiao, Y; Zhang, C; Li, A; Wang, D; Luo, Z; Ping, Y; Zhou, B; Liu, S; Li, H; Yue, D; Zhang, Z; Chen, X; Shen, Z; Lian, J; Li, Y; Wang, S; Li, F; Huang, L; Wang, L; Zhang, B; Yu, J; Qin, Z; Zhang, Y  (2018). IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma. Oncogene, 37 (7) , 873-883More Information

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J  (2017). Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells. Molecular cancer research : MCR, 15 (10) , 1318-1330More Information

Xiaolei Liu , Erik Zhang , Kopras Elizabeth J. , Eric Smith , Yiyang Lu , Aristoteli Astreinidis , Yuet-Kin Leung , Shuk-Mei Ho , Maciej Markiewski , MAGDALENA KARBOWNICZEK , Manoocher Soleimani , Chenggang Li, and Jane J. YU  (2019). mTORC1 and estrogen cooperate to induce pyruvate kinase M2 phosphorylation and increase the survival of TSC2-deficient cells. Oncogenesis

Jiange Qiu, Qianqian Li, Katherine A. Bell, Xue Yao, Erik Zhang, Jane J. Yu, Zhi Shi, and Jianxiong Jiang  (2019). Small-molecule inhibition of prostaglandin receptor EP2 impairs cyclooxygenase-associated malignant glioma growth. British Journal of Pharmacology