William Zacharias

William Zacharias

Assistant Professor-Affiliate

Childrens Hospital Bldg R

R4566

COM Pediatrics Pulmonary Biology - 0054

Education

University Hospital of Pennsylvaniz Philadelphia, PA, 2012 (Internship in Internal Medicine)

University Hospital of Pennsylvania Philadelphia, PA, 2013 (Residency in Internal Medicine)

University Hospital of Pennsylvania Philadelphia, PA, 2017 (Fellowship in Pulmonary and Critical Care Medicine)

University Hospital of Pennsylvania Philadelphia, PA, 2018 (Postdoctoral Fellow)

B.A., Northwestern University Evanston, IL, 2003 (Biological Sciences; Departmental Honors for Research in Biology)

M.D., Univeristy of Michigan Ann Arbor, MI, 2011 (School of Medicine, Ph.D., Dept. of Cell and Developmental Biology)

Clinical Focus

Critical Care Medicine

Specialities

Critical Care Medicine

Internal Medicine

Certifications

American Board of Internal Medicine (Critical Care Medicine)

10/18/2017

American Board of Internal Medicine

08/03/2015

American Board of Internal Medicine (Pulmonary Disease)

10/05/2016

Research Support

Grant: #K08-HL140178 07-21-2018 -06-30-2023 NIH/NHLBI Mechanistic evaluation of a novel WNT-responsive adult alveolar epithelial progenitor population during regeneration after diffuse alveolar damage Role:PI 163080 Active Type:Grant

Publications

Peer Reviewed Publications

Jacob, Anjali; Morley, Michael; Hawkins, Finn; McCauley, Katherine B; Jean, J C; Heins, Hillary; Na, Cheng-Lun; Weaver, Timothy E; Vedaie, Marall; Hurley, Killian; Hinds, Anne; Russo, Scott J; Kook, Seunghyi; Zacharias, William; Ochs, Matthias; Traber, Katrina; Quinton, Lee J; Crane, Ana; Davis, Brian R; White, Frances V; Wambach, Jennifer; Whitsett, Jeffrey A; Cole, F Sessions; Morrisey, Edward E; Guttentag, Susan H; Beers, Michael F; Kotton, Darrell N (2017. ) Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.Cell stem cell, , 21 (4 ) ,472-488.e10

Paris, Andrew J; Liu, Yuhong; Mei, Junjie; Dai, Ning; Guo, Lei; Spruce, Lynn A; Hudock, Kristin M; Brenner, Jacob S; Zacharias, William J; Mei, Hankun D; Slamowitz, April R; Bhamidipati, Kartik; Beers, Michael F; Seeholzer, Steven H; Morrisey, Edward E; Worthen, G Scott (2016. ) Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.American journal of physiology. Lung cellular and molecular physiology, , 311 (6 ) ,L1062-L1075

Zacharias, William J; Frank, David B; Zepp, Jarod A; Morley, Michael P; Alkhaleel, Farrah A; Kong, Jun; Zhou, Su; Cantu, Edward; Morrisey, Edward E (2018. ) Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor.Nature, , 555 (7695 ) ,251-255

Zepp, Jarod A; Zacharias, William J; Frank, David B; Cavanaugh, Christina A; Zhou, Su; Morley, Michael P; Morrisey, Edward E (2017. ) Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung.Cell, , 170 (6 ) ,1134-1148.e10

Zacharias, William J; Madison, Blair B; Kretovich, Katherine E; Walton, Katherine D; Richards, Neil; Udager, Aaron M; Li, Xing; Gumucio, Deborah L (2011. ) Hedgehog signaling controls homeostasis of adult intestinal smooth muscle.Developmental biology, , 355 (1 ) ,152-62

Zacharias, William J; Li, Xing; Madison, Blair B; Kretovich, Katherine; Kao, John Y; Merchant, Juanita L; Gumucio, Deborah L (2010. ) Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria.Gastroenterology, , 138 (7 ) ,2368-77, 2377.e1-4

Kolterud, Asa; Grosse, Ann S; Zacharias, William J; Walton, Katherine D; Kretovich, Katherine E; Madison, Blair B; Waghray, Meghna; Ferris, Jennifer E; Hu, Chunbo; Merchant, Juanita L; Dlugosz, Andrzej A; Kottmann, Andreas H; Gumucio, Deborah L (2009. ) Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.Gastroenterology, , 137 (2 ) ,618-28

Lees, Charlie W; Zacharias, William J; Tremelling, Mark; Noble, Colin L; Nimmo, Elaine R; Tenesa, Albert; Cornelius, Jennine; Torkvist, Leif; Kao, John; Farrington, Susan; Drummond, Hazel E; Ho, Gwo-Tzer; Arnott, Ian D R; Appelman, Henry D; Diehl, Lauri; Campbell, Harry; Dunlop, Malcolm G; Parkes, Miles; Howie, Sarah E M; Gumucio, Deborah L; Satsangi, Jack (2008. ) Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.PLoS medicine, , 5 (12 ) ,e239

Rossidis, Avery C; Stratigis, John D; Chadwick, Alexandra C; Hartman, Heather A; Ahn, Nicholas J; Li, Haiying; Singh, Kshitiz; Coons, Barbara E; Li, Li; Lv, Wenjian; Zoltick, Philip W; Alapati, Deepthi; Zacharias, William; Jain, Rajan; Morrisey, Edward E; Musunuru, Kiran; Peranteau, William H (2018. ) In utero CRISPR-mediated therapeutic editing of metabolic genes.Nature medicine, , 24 (10 ) ,1513-1518

Dolinay, Tamás; Aonbangkhen, Chanat; Zacharias, William; Cantu, Edward; Pogoriler, Jennifer; Stablow, Alec; Lawrence, Gladys G; Suzuki, Yoshikazu; Chenoweth, David M; Morrisey, Edward; Christie, Jason D; Beers, Michael F; Margulies, Susan S (2018. ) Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.Respiratory research, , 19 (1 ) ,157

Krause, Ange; Zacharias, William; Camarata, Troy; Linkhart, Barbara; Law, Evelyn; Lischke, Antje; Miljan, Erik; Simon, Hans-Georg (2004. ) Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development.Developmental biology, , 273 (1 ) ,106-20

Paris, Andrew J; Hayer, Katharina E; Oved, Joseph H; Avgousti, Daphne C; Toulmin, Sushila A; Zepp, Jarod A; Zacharias, William J; Katzen, Jeremy B; Basil, Maria C; Kremp, Madison M; Slamowitz, April R; Jayachandran, Sowmya; Sivakumar, Aravind; Dai, Ning; Wang, Ping; Frank, David B; Eisenlohr, Laurence C; Cantu, Edward; Beers, Michael F; Weitzman, Matthew D; Morrisey, Edward E; Worthen, G Scott (2020. ) STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.Nature cell biology, , 22 (10 ) ,1197-1210

Jackson, Courtney M; Mukherjee, Shibabrata; Wilburn, Adrienne N; Cates, Chris; Lewkowich, Ian P; Deshmukh, Hitesh; Zacharias, William J; Chougnet, Claire A (2020. ) Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms.Frontiers in immunology, , 11 ,1285

Rajaram, Sanjeeth; Canaday, Laura M; Ochayon, David E; Rangel, Kelly M; Ali, Ayad; Gyurova, Ivayla E; Krishnamurthy, Durga; Fletcher, Jonathan S; Reighard, Seth D; Cox, Andrew; Weirauch, Matthew T; Kottyan, Leah C; Deshmukh, Hitesh; Zacharias, William J; Borchers, Michael T; Waggoner, Stephen N (2020. ) The Promise and Peril of Natural Killer Cell Therapies in Pulmonary Infection.Immunity, , 52 (6 ) ,887-889

Swarr, Daniel; Putcha, Nirupama; Zacharias, William (2020. ) "PIK"ing Out New Epigenetic Markers in Lung Disease.American journal of respiratory and critical care medicine, , 201 (9 ) ,1029-1030

Oherle, Katherine; Acker, Elizabeth; Bonfield, Madeline; Wang, Timothy; Gray, Jerilyn; Lang, Ian; Bridges, James; Lewkowich, Ian; Xu, Yan; Ahlfeld, Shawn; Zacharias, William; Alenghat, Theresa; Deshmukh, Hitesh (2020. ) Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs.Immunity, , 52 (4 ) ,716-718

Basil, Maria C; Katzen, Jeremy; Engler, Anna E; Guo, Minzhe; Herriges, Michael J; Kathiriya, Jaymin J; Windmueller, Rebecca; Ysasi, Alexandra B; Zacharias, William J; Chapman, Hal A; Kotton, Darrell N; Rock, Jason R; Snoeck, Hans-Willem; Vunjak-Novakovic, Gordana; Whitsett, Jeffrey A; Morrisey, Edward E (2020. ) The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.Cell stem cell, , 26 (4 ) ,482-502

Oherle, Katherine; Acker, Elizabeth; Bonfield, Madeline; Wang, Timothy; Gray, Jerilyn; Lang, Ian; Bridges, James; Lewkowich, Ian; Xu, Yan; Ahlfeld, Shawn; Zacharias, William; Alenghat, Theresa; Deshmukh, Hitesh (2020. ) Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs.Immunity, , 52 (2 ) ,275-294.e9

Xiao, Deyi; Li, Xiaohong; Rouchka, Eric C; Waigel, Sabine; Zacharias, Wolfgang; McMasters, Kelly M; Hao, Hongying (2020. ) Comparative gene expression analysis in melanocytes driven by tumor cell-derived exosomes.Experimental cell research, , 386 (1 ) ,111690

Tighe, Robert M; Redente, Elizabeth F; Yu, Yen-Rei; Herold, Susanne; Sperling, Anne I; Curtis, Jeffrey L; Duggan, Ryan; Swaminathan, Suchitra; Nakano, Hideki; Zacharias, William J; Janssen, William J; Freeman, Christine M; Brinkman, Ryan R; Singer, Benjamin D; Jakubzick, Claudia V; Misharin, Alexander V (2019. ) Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.American journal of respiratory cell and molecular biology, , 61 (2 ) ,150-161

Alapati, Deepthi; Zacharias, William J; Hartman, Heather A; Rossidis, Avery C; Stratigis, John D; Ahn, Nicholas J; Coons, Barbara; Zhou, Su; Li, Hiaying; Singh, Kshitiz; Katzen, Jeremy; Tomer, Yaniv; Chadwick, Alexandra C; Musunuru, Kiran; Beers, Michael F; Morrisey, Edward E; Peranteau, William H (2019. ) In utero gene editing for monogenic lung disease.Science translational medicine, , 11 (488 ) ,

Frank, David B; Penkala, Ian J; Zepp, Jarod A; Sivakumar, Aravind; Linares-Saldana, Ricardo; Zacharias, William J; Stolz, Katharine G; Pankin, Josh; Lu, MinQi; Wang, Qiaohong; Babu, Apoorva; Li, Li; Zhou, Su; Morley, Michael P; Jain, Rajan; Morrisey, Edward E (2019. ) Early lineage specification defines alveolar epithelial ontogeny in the murine lung.Proceedings of the National Academy of Sciences of the United States of America, , 116 (10 ) ,4362-4371