Yana Zavros

Yana Zavros , PhD

Professor of Physiology; Co-Director UC WISE-REWU Program

Office 4255 Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267-0576
Phone (513)558-2421
Fax (513)558-5738
Email yana.zavros@uc.edu

Professional Summary

I.            Research Interests

Gastric cancer develops from long-term inflammation that is typically caused by the bacteria Helicobacter pylori (H. pylori).   During H. pylori-induced inflammation to cancer there are a number of changes that occur within the gastric epithelium.  These include loss of gastric epithelial cell differentiation, parietal cell atrophy and infiltration of lymphocytes.  Although it is accepted that inflammation precedes these pre-neoplastic changes, the mechanism by which inflammation triggers the development of cancer is unknown.  Sonic Hedgehog (Shh), a morphogen originally identified for its role in embryogenesis, is believed to regulate adult epithelial cell homeostasis.  In fact, coincident with H. pylori infection is the loss of Shh expression and this would then be expected to result in loss of normal epithelial cell differentiation.  The overall focus and objective of my research is to define the mechanism(s) by which Shh acts as a constituent of gastric epithelial cell homeostasis and carcinogenesis.  The detailed topics of my research projects are as follows:

Project 1:            What is the mechanism by which Hedgehog signaling acts as a regulator of gastric epithelial cell differentiation and function?
            Project 1 investigates the regulation of normal differentiation and function of the adult stomach as impacted by the cellular location of Shh expression and secretion within the stomach to.  Data from our laboratory has shown that the Hedgehog signaling pathway regulates the expression of E cadherin, and the loss of Hedgehog signaling in the stomach subsequently results in disruption of E cadherin expression and translocation of beta catenin from the cell membrane to the cytoplasm and nucleus.  This results in the activation the Wnt pathway, increased proliferation, disruption of normal gastric epithelial differentiation and function.
 
Project 2:            What is the mechanism by which Sonic Hedgehog regulates the host immune response during H. pylori infection?
The H. pylori infected mucosa exhibits a T-helper 1 (TH1) immune response characterized by recruitment of primarily interferon gamma (IFNg)-expressing T lymphocytes to the stomach.  Although gastritis due to H. pylori is induced by a TH1-mediated response that is T cell and IFNgdependent, the mechanism regulating the development of such an inflammatory response is unclear.  In addition to the essential role for patterning during embryogenesis and maintenance of adult tissue homeostasis, Shh is also known to be a regulator of T cell differentiation and cytokine production.  However, the role of Shh in the development of H. pylori-induced gastritis has not been investigated.  Project 2 studies the role of Hedgehog signaling in the development of the initial host immune response triggered by bacterial infection.
 
Project 3:            What is the role of Hedgehog signaling in the development of gastric cancer?
In gastric cancer tissue, histological alterations and changes in cell composition coincide with the over-expression of Shh that contributes to angiogenesis and tumor growth.  My collaborator Dr. JeanMarie Houghton (University of Massachusetts Medical School) has shown that the recruitment of bone marrow-derived mesenchymal stem cells (MSCs) to the stomach during chronic inflammation, acquire the gastric mu

Research and Practice Interests

Research Support

Grant: #CCHMC 103952 / P30 DK078392 Investigators:Zavros, Yana 06-01-2008 -05-31-2009 National Inst of Diabetes and Digestive and Kidney Disease Role of Inflammation and Sonic Hedgehog in the Development of Gastric Cancer Role:PI $25,000.00 Closed Level:Federal

Grant: #RSG-10-167-01-MPC Investigators:Zavros, Yana 07-01-2010 -06-30-2014 American Cancer Society - National Chapter Role of Hedgehog Signaling in the Development of Gastric Cancer Role:PI $540,000.00 Active Level:Private Non-Profit

Grant: #R01 DK083402 Investigators:Zavros, Yana 02-01-2011 -01-31-2016 National Inst of Diabetes and Digestive and Kidney Disease The Role of Hedgehog Signaling in Gastric Tissue Homeostasis and Disease Role:PI $1,026,668.00 Active Level:Federal

Grant: #AGA Award Contract Investigators:Zavros, Yana 01-01-2013 -12-31-2014 American Gastroenterological Association Helicobacter Pylori-Epithelial Cell Interactions And The Aberrant Proliferation Of The Gastric Epithelium Role:PI $100,000.00 Active Level:Private Non-Profit

Grant: #T32 GM105526 Investigators:Meller, Jaroslaw; Montrose, Marshall; Zavros, Yana 07-01-2013 -06-30-2016 National Institute of General Medical Sciences Advanced Multidisciplinary Training Program for Systems Biology Role:PI $261,961.00 Active Level:Federal

Grant: #U19 AI116491 Investigators:Hong, Christian; Moore, Sean; Weiss, Alison; Wells, James; Zavros, Yana 03-01-2015 -02-29-2020 National Institute of Allergy and Infectious Diseases Organoids as a Model System for Studying Gastrointestinal Disease Role:Collaborator $931,304.00 Awarded Level:Federal

Grant: #R01DK083402 Investigators:Zavros, Yana 07-01-2016 -04-30-2020 National Inst of Diabetes and Digestive and Kidney Disease The role of Hedgehog Signaling in gastric tissue repair and regeneration Role:PI $501,964.00 Active Level:Federal

Grant: #T35DK060444 Investigators:Heubi, James; Zavros, Yana 04-01-2019 -03-31-2024 National Inst of Diabetes and Digestive and Kidney Disease Short-Term Institutional Research Training Grant Role:Collaborator $66,993.00 Awarded Level:Federal

Publications

Published Abstracts

Donnelly JM, Chawla A, Xiao C, Orr MA, Houghton J and Zavros Y. (2009. ) Hedgehog Signaling Mediates IFN-gamma-Induced Mesenchymal Stem Cell Recruitment during Gastric Infection.

J Martin and Y. Zavros. (2009. ) Hedgehog signaling and the development of gastric cancer. .[Abstract]Digestive Diseases and Sciences,

Miller ML, Andringa A, Spicer Z, Schultheis PJ, Zavros Y, Bradford EM and Shull GE. (2009. ) Parietal secretory cell volume density, distribution and ultrastructure of secretory membranes and mitochondria predict (dys)function. Journal of Biomedicine and Biotechnology - Epithelium Molecular Landscaping for an Interactive Barrier,

Waghray M, Zavros Y, Saqui-Salces M, Todisco A, Eaton KA, Merchant JL. (2009. ) Interleukin-1 Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog. .[Abstract] Gastroenterology,

Robert Tokhunts, Samer Singh, Tehyen Chu, Gisela D’Angelo, Valerie Baubet, John A Goetz, Zhen Huang, Ziqiang Yuan, Manuel Ascano, Yana Zavros, Pascal P. Thérond, Sam Kunes, Nadia Dahmane, and David J. Robbins. (2009. ) The Unprocessed Full-Length HEDGEHOG Protein Has Activity as a Short Range Signaling Molecule. PNAS,

M El-Zaatari, Y Zavros, A Tessier, M Waghray, A Todisco, and J.L. Merchant. (2009. ) Acid regulation of Shh gene expression is mediated by intracellular calcium release. .[Abstract]MCB,

Xiao C, Ogle S, Orr MA, Miller ML, Varro A, Hollande F and Zavros Y. (2009. ) Parietal Cell-Expressed Sonic Hedgehog Is Required for Maintenance of a Functional and Differentiated Gastric Epithelium. .[Abstract]Gastroenterology,

Xiao C, Ogle S, Orr-Asman M, Hollande F and Zavros Y. (2009. ) Hedgehog Signaling Regulates the Distribution of ZO-1 and Barrier Function of the Gastric Epithelium. BBRC,

Zavros Y, Orr MA, Xiao, C and Malinowska DH. (2008. ) Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. Am J Phyisol. , (295 ) ,G99-G111

Kang W, Saqui-Salces M, Zavros Y, Merchant JL (2008. ) Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochem Biophys Res Commun, (376(3) ) ,573-577

Mensah-Osman E, Zavros Y, Merchant JL. (2008. ) Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol., (295(4) ) ,G843-854

Mensah-Osman E, Labut E, Zavros Y, El-Zaatari M, Law DJ, Merchant JL. (2008. ) Regulated expression of the human gastrin gene in mice. Regul Pept., (151(1-3) ) ,115-122

Donnelly J and Zavros Y. Sonic Hedgehog signaling modulates the recruitment of T cells to the gastric mucosa during Helicobacter-induced inflammation. .[Abstract]

Peer Reviewed Publications

Teal, Emma; Steele, Nina G; Chakrabarti, Jayati; Holokai, Loryn; Zavros, Yana (2018. ) Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration.Journal of visualized experiments : JoVE, , (135 ) , More Information

Zavros, Yana (2018. ) The Novel Role of Lgr5 as a Regulator of Cell Homeostasis and Disease of the Gastric Oxyntic Mucosa.Cellular and molecular gastroenterology and hepatology, , 5 (4 ) ,645-646 More Information

Chakrabarti, Jayati; Holokai, Loryn; Syu, LiJyun; Steele, Nina; Chang, Julie; Dlugosz, Andrzej; Zavros, Yana (2018. ) Mouse-Derived Gastric Organoid and Immune Cell Co-culture for the Study of the Tumor Microenvironment.Methods in molecular biology (Clifton, N.J.), , 1817 ,157-168 More Information

Teal, Emma; Bertaux-Skeirik, Nina; Chakrabarti, Jayati; Holokai, Loryn; Zavros, Yana (2018. ) Establishment of Human- and Mouse-Derived Gastric Primary Epithelial Cell Monolayers from Organoids.Methods in molecular biology (Clifton, N.J.), , 1817 ,145-155 More Information

Bertaux-Skeirik, Nina; Wunderlich, Mark; Teal, Emma; Chakrabarti, Jayati; Biesiada, Jacek; Mahe, Maxime; Sundaram, Nambirajan; Gabre, Joel; Hawkins, Jennifer; Jian, Gao; Engevik, Amy C; Yang, Li; Wang, Jiang; Goldenring, James R; Qualls, Joseph E; Medvedovic, Mario; Helmrath, Michael A; Diwan, Tayyab; Mulloy, James C; Zavros, Yana (2017. ) CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.The Journal of pathology, , 242 (4 ) ,463-475 More Information

Braune, Julia; Weyer, Ulrike; Matz-Soja, Madlen; Hobusch, Constance; Kern, Matthias; Kunath, Anne; Klöting, Nora; Kralisch, Susann; Blüher, Matthias; Gebhardt, Rolf; Zavros, Yana; Bechmann, Ingo; Gericke, Martin (2017. ) Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism.Diabetologia, , 60 (5 ) ,889-899 More Information

Zavros, Yana (2017. ) Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells.Cellular and molecular gastroenterology and hepatology, , 4 (1 ) ,55-63 More Information

Konstantinou, Daniel; Bertaux-Skeirik, Nina; Zavros, Yana (2016. ) Hedgehog signaling in the stomach.Current opinion in pharmacology, , 31 ,76-82 More Information

Keilberg, Daniela; Zavros, Yana; Shepherd, Benjamin; Salama, Nina R; Ottemann, Karen M (2016. ) Spatial and Temporal Shifts in Bacterial Biogeography and Gland Occupation during the Development of a Chronic Infection.mBio, , 7 (5 ) , More Information

Bertaux-Skeirik, Nina; Centeno, Jomaris; Gao, Jian; Gabre, Joel; Zavros, Yana (2016. ) Oncogenic Transformation of Human-Derived Gastric Organoids.Methods in molecular biology (Clifton, N.J.), , More Information

Engevik, Amy C; Feng, Rui; Choi, Eunyoung; White, Shana; Bertaux-Skeirik, Nina; Li, Jing; Mahe, Maxime M; Aihara, Eitaro; Yang, Li; DiPasquale, Betsy; Oh, Sunghee; Engevik, Kristen A; Giraud, Andrew S; Montrose, Marshall H; Medvedovic, Mario; Helmrath, Michael A; Goldenring, James R; Zavros, Yana (2016. ) The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.Cellular and molecular gastroenterology and hepatology, , 2 (5 ) ,605-624 More Information

Dedhia, Priya H; Bertaux-Skeirik, Nina; Zavros, Yana; Spence, Jason R (2016. ) Organoid Models of Human Gastrointestinal Development and Disease.Gastroenterology, , 150 (5 ) ,1098-1112 More Information

Bertaux-Skeirik, Nina; Centeno, Jomaris; Feng, Rui; Schumacher, Michael A; Shivdasani, Ramesh A; Zavros, Yana (2016. ) Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells.Methods in molecular biology (Clifton, N.J.), , 1422 ,23-31 More Information

Aihara, Eitaro; Mahe, Maxime M; Schumacher, Michael A; Matthis, Andrea L; Feng, Rui; Ren, Wenwen; Noah, Taeko K; Matsu-ura, Toru; Moore, Sean R; Hong, Christian I; Zavros, Yana; Herness, Scott; Shroyer, Noah F; Iwatsuki, Ken; Jiang, Peihua; Helmrath, Michael A; Montrose, Marshall H (2015. ) Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.Scientific reports, , 5 ,17185 More Information

Wroblewski, Lydia E; Piazuelo, M Blanca; Chaturvedi, Rupesh; Schumacher, Michael; Aihara, Eitaro; Feng, Rui; Noto, Jennifer M; Delgado, Alberto; Israel, Dawn A; Zavros, Yana; Montrose, Marshall H; Shroyer, Noah; Correa, Pelayo; Wilson, Keith T; Peek, Richard M (2015. ) Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells.Gut, , 64 (5 ) ,720-30 More Information

Schumacher, Michael A; Aihara, Eitaro; Feng, Rui; Engevik, Amy; Shroyer, Noah F; Ottemann, Karen M; Worrell, Roger T; Montrose, Marshall H; Shivdasani, Ramesh A; Zavros, Yana (2015. ) The use of murine-derived fundic organoids in studies of gastric physiology.The Journal of physiology, , 593 (8 ) ,1809-27 More Information

Schumacher, Michael A; Feng, Rui; Aihara, Eitaro; Engevik, Amy C; Montrose, Marshall H; Ottemann, Karen M; Zavros, Yana (2015. ) Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NF?B pathway activation: the use of a novel in vitro model to study epithelial response to infection.Helicobacter, , 20 (1 ) ,19-28 More Information

Bertaux-Skeirik, Nina; Feng, Rui; Schumacher, Michael A; Li, Jing; Mahe, Maxime M; Engevik, Amy C; Javier, Jose E; Peek, Richard M; Ottemann, Karen; Orian-Rousseau, Veronique; Boivin, Gregory P; Helmrath, Michael A; Zavros, Yana (2015. ) CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.PLoS pathogens, , 11 (2 ) ,e1004663 More Information

McCracken, Kyle W; Catá, Emily M; Crawford, Calyn M; Sinagoga, Katie L; Schumacher, Michael; Rockich, Briana E; Tsai, Yu-Hwai; Mayhew, Christopher N; Spence, Jason R; Zavros, Yana; Wells, James M (2014. ) Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.Nature, , 516 (7531 ) ,400-4 More Information

Feng, Rui; Aihara, Eitaro; Kenny, Susan; Yang, Li; Li, Jing; Varro, Andrea; Montrose, Marshall H; Shroyer, Noah F; Wang, Timothy C; Shivdasani, Ramesh A; Zavros, Yana (2014. ) Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.Gastroenterology, , 147 (3 ) ,655-666.e9 More Information

Aihara, Eitaro; Closson, Chet; Matthis, Andrea L; Schumacher, Michael A; Engevik, Amy C; Zavros, Yana; Ottemann, Karen M; Montrose, Marshall H (2014. ) Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori.PLoS pathogens, , 10 (7 ) ,e1004275 More Information

Donnelly, Jessica M; Engevik, Amy; Feng, Rui; Xiao, Chang; Boivin, Gregory P; Li, Jing; Houghton, JeanMarie; Zavros, Yana (2014. ) Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach.American journal of physiology. Gastrointestinal and liver physiology, , 306 (12 ) ,G1075-88 More Information

Marwaha, Shruti; Schumacher, Michael A; Zavros, Yana; Eghbalnia, Hamid R (2014. ) Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model.PloS one, , 9 (11 ) ,e111338 More Information

Donnelly, Jessica M; Engevik, Amy C; Engevik, Melinda; Schumacher, Michael A; Xiao, Chang; Yang, Li; Worrell, Roger T; Zavros, Yana (2014. ) Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell.Digestive diseases and sciences, , 59 (3 ) ,569-82 More Information

Engevik, Amy C; Feng, Rui; Yang, Li; Zavros, Yana (2013. ) The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair.Endocrinology, , 154 (12 ) ,4627-39 More Information

Xiao, Chang; Feng, Rui; Engevik, Amy C; Martin, Jason R; Tritschler, Julie A; Schumacher, Michael; Koncar, Robert; Roland, Joseph; Nam, Ki Taek; Goldenring, James R; Zavros, Yana (2013. ) Sonic Hedgehog contributes to gastric mucosal restitution after injury.Laboratory investigation; a journal of technical methods and pathology, , 93 (1 ) ,96-111 More Information

Donnelly, Jessica M; Chawla, Ambreesh; Houghton, Jeanmarie; Zavros, Yana (2013. ) Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach.PloS one, , 8 (9 ) ,e75225 More Information

Mahé, Maxime M; Aihara, Eitaro; Schumacher, Michael A; Zavros, Yana; Montrose, Marshall H; Helmrath, Michael A; Sato, Toshiro; Shroyer, Noah F (2013. ) Establishment of gastrointestinal epithelial organoids.Current protocols in mouse biology, , 3 ,217-240 More Information

Zavros, Yana; Rogler, Gerhard (2012. ) Variants in autophagy genes affect susceptibility to both Crohn's disease and Helicobacter pylori infection.Gastroenterology, , 142 (5 ) ,1060-3 More Information

Schumacher, Michael A; Donnelly, Jessica M; Engevik, Amy C; Xiao, Chang; Yang, Li; Kenny, Susan; Varro, Andrea; Hollande, Frédéric; Samuelson, Linda C; Zavros, Yana (2012. ) Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori.Gastroenterology, , 142 (5 ) ,1150-1159.e6 More Information

Craig, Michael; Schumacher, Michael; Zavros, Yana (2012. ) Techniques for following labeled cells in vivo: use of X/Y FISH, techniques to optimize fluorescent detection, and beta-galactosidase detection.Methods in molecular biology (Clifton, N.J.), , 921 ,227-38 More Information

Feng, Rui; Xiao, Chang; Zavros, Yana (2012. ) The role of Sonic Hedgehog as a regulator of gastric function and differentiation.Vitamins and hormones, , 88 ,473-89 More Information

Sherman, Alexander E; Zavros, Yana (2011. ) Role of Sonic Hedgehog signaling during progression from inflammation to cancer in the stomach.World journal of gastrointestinal pathophysiology, , 2 (6 ) ,103-8 More Information

Zavros, Yana; Mesiwala, Nisreen; Waghray, Meghna; Todisco, Andrea; Shulkes, Arthur; Merchant, Juanita L (2010. ) Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis.World journal of gastrointestinal pathophysiology, , 1 (5 ) ,154-65 More Information

Xiao, Chang; Ogle, Sally A; Schumacher, Michael A; Schilling, Neal; Tokhunts, Robert A; Orr-Asman, Melissa A; Miller, Marian L; Robbins, David J; Hollande, Frederic; Zavros, Yana (2010. ) Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions.American journal of physiology. Gastrointestinal and liver physiology, , 299 (6 ) ,G1252-65 More Information

El-Zaatari, Mohamad; Zavros, Yana; Tessier, Art; Waghray, Meghna; Lentz, Steve; Gumucio, Deborah; Todisco, Andrea; Merchant, Juanita L (2010. ) Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion.Gastroenterology, , 139 (6 ) ,2061-2071.e2 More Information

Xiao, Chang; Ogle, Sally A; Schumacher, Michael A; Orr-Asman, Melissa A; Miller, Marian L; Lertkowit, Nantaporn; Varro, Andrea; Hollande, Frederic; Zavros, Yana (2010. ) Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.Gastroenterology, , 138 (2 ) ,550-61, 561.e1-8 More Information

Waghray, Meghna; Zavros, Yana; Saqui-Salces, Milena; El-Zaatari, Mohamad; Alamelumangapuram, C Bharath; Todisco, Andrea; Eaton, Kathryn A; Merchant, Juanita L (2010. ) Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog.Gastroenterology, , 138 (2 ) ,562-72, 572.e1-2 More Information

Tokhunts, Robert; Singh, Samer; Chu, Tehyen; D'Angelo, Gisela; Baubet, Valerie; Goetz, John A; Huang, Zhen; Yuan, Ziqiang; Ascano, Manuel; Zavros, Yana; Thérond, Pascal P; Kunes, Sam; Dahmane, Nadia; Robbins, David J (2010. ) The full-length unprocessed hedgehog protein is an active signaling molecule.The Journal of biological chemistry, , 285 (4 ) ,2562-8 More Information

Miller, Marian L; Andringa, Anastasia; Zavros, Yana; Bradford, Emily M; Shull, Gary E (2010. ) Volume density, distribution, and ultrastructure of secretory and basolateral membranes and mitochondria predict parietal cell secretory (dys)function.Journal of biomedicine & biotechnology, , 2010 ,394198 More Information

Martin, Jason; Donnelly, Jessica M; Houghton, JeanMarie; Zavros, Yana (2010. ) The role of Sonic Hedgehog reemergence during gastric cancer.Digestive diseases and sciences, , 55 (6 ) ,1516-24 More Information

Xiao C, Ogle S, Orr-Asman M, Hollande F and Zavros Y. (2009. ) Hedgehog Signaling Regulates the Distribution of ZO-1 and Barrier Function of the Gastric Epithelium. .BBRC, ,

Donnelly J and Zavros Y. (2009. ) Sonic Hedgehog signaling modulates the recruitment of T cells to the gastric mucosa during Helicobacter-induced inflammation. .Infection and Immunity, ,

Donnelly JM, Chawla A, Xiao C, Orr MA, Houghton J and Zavros Y (2009. ) Hedgehog Signaling Mediates IFN-gamma-Induced Mesenchymal Stem Cell Recruitment during Gastric Infection. .Cancer Research, ,

M El-Zaatari, Y Zavros, A Tessier, M Waghray, A Todisco, and J.L. Merchant. (2009. ) Acid regulation of Shh gene expression is .MCB, ,

Mensah-Osman, Edith; Labut, Ed; Zavros, Yana; El-Zaatari, Mohamad; Law, David J; Merchant, Juanita L (2008. ) Regulated expression of the human gastrin gene in mice.Regulatory peptides, , 151 (1-3 ) ,115-22 More Information

Kang, Weiqun; Saqui-Salces, Milena; Zavros, Yana; Merchant, Juanita L (2008. ) Induction of follistatin precedes gastric transformation in gastrin deficient mice.Biochemical and biophysical research communications, , 376 (3 ) ,573-7 More Information

Mensah-Osman, Edith; Zavros, Yana; Merchant, Juanita L (2008. ) Somatostatin stimulates menin gene expression by inhibiting protein kinase A.American journal of physiology. Gastrointestinal and liver physiology, , 295 (4 ) ,G843-54 More Information

Zavros, Yana; Orr, Melissa A; Xiao, Chang; Malinowska, Danuta H (2008. ) Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation.American journal of physiology. Gastrointestinal and liver physiology, , 295 (1 ) ,G99-G111 More Information

Zavros, Yana (2008. ) The adventures of sonic hedgehog in development and repair. IV. Sonic hedgehog processing, secretion, and function in the stomach.American journal of physiology. Gastrointestinal and liver physiology, , 294 (5 ) ,G1105-8 More Information

Zavros, Yana; Waghray, Meghna; Tessier, Arthur; Bai, Longchuan; Todisco, Andrea; L Gumucio, Deborah; Samuelson, Linda C; Dlugosz, Andrzej; Merchant, Juanita L (2007. ) Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation.The Journal of biological chemistry, , 282 (46 ) ,33265-74 More Information

Kao, John Y; Rathinavelu, Sivaprakash; Eaton, Kathryn A; Bai, Longchuan; Zavros, Yana; Takami, Mimi; Pierzchala, Anna; Merchant, Juanita L (2006. ) Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense.American journal of physiology. Gastrointestinal and liver physiology, , 291 (1 ) ,G73-81 More Information

Lopez-Diaz, Lymari; Hinkle, Karen L; Jain, Renu N; Zavros, Yana; Brunkan, Cynthia S; Keeley, Theresa; Eaton, Kathryn A; Merchant, Juanita L; Chew, Catherine S; Samuelson, Linda C (2006. ) Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice.American journal of physiology. Gastrointestinal and liver physiology, , 290 (5 ) ,G970-9 More Information

Kao, John Y; Pierzchala, Anna; Rathinavelu, Sivaprakash; Zavros, Yana; Tessier, Arthur; Merchant, Juanita L (2006. ) Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori.Regulatory peptides, , 134 (1 ) ,23-9 More Information

Rathinavelu, Sivaprakash; Kao, John Y; Zavros, Yana; Merchant, Juanita L (2005. ) Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function.Helicobacter, , 10 (5 ) ,424-32 More Information

Stepan, Vinzenz; Ramamoorthy, Saravanan; Nitsche, Hildegard; Zavros, Yana; Merchant, Juanita L; Todisco, Andrea (2005. ) Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells.The Journal of biological chemistry, , 280 (16 ) ,15700-8 More Information

Zavros, Yana; Eaton, Kathryn A; Kang, Weiqun; Rathinavelu, Sivaprakash; Katukuri, Vinay; Kao, John Y; Samuelson, Linda C; Merchant, Juanita L (2005. ) Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma.Oncogene, , 24 (14 ) ,2354-66 More Information

Zavros, Yana; Merchant, Juanita L (2005. ) Modulating the cytokine response to treat Helicobacter gastritis.Biochemical pharmacology, , 69 (3 ) ,365-71 More Information

Zavros, Yana; Kao, John Y; Merchant, Juanita L (2004. ) Inflammation and cancer III. Somatostatin and the innate immune system.American journal of physiology. Gastrointestinal and liver physiology, , 286 (5 ) ,G698-701 More Information

Zavros, Yana; Rathinavelu, Sivaprakash; Kao, John Y; Todisco, Andrea; Del Valle, John; Weinstock, Joel V; Low, Malcolm J; Merchant, Juanita L (2003. ) Treatment of Helicobacter gastritis with IL-4 requires somatostatin.Proceedings of the National Academy of Sciences of the United States of America, , 100 (22 ) ,12944-9 More Information

Rathinavelu, Sivaprakash; Zavros, Yana; Merchant, Juanita L (2003. ) Acinetobacter lwoffii infection and gastritis. Microbes and infection / Institut Pasteur, , 5 (7 ) ,651-7

Joseph, Ian M P; Zavros, Yana; Merchant, Juanita L; Kirschner, Denise (2003. ) A model for integrative study of human gastric acid secretion.Journal of applied physiology (Bethesda, Md. : 1985), , 94 (4 ) ,1602-18 More Information

Zavros, Y; Rieder, G; Ferguson, Amy; Merchant, J L (2002. ) Gastritis and hypergastrinemia due to Acinetobacter lwoffii in mice. Infection and immunity, , 70 (5 ) ,2630-9

Zavros, Yana; Rieder, Gabriele; Ferguson, Amy; Samuelson, Linda C; Merchant, Juanita L (2002. ) Hypergastrinemia in response to gastric inflammation suppresses somatostatin.American journal of physiology. Gastrointestinal and liver physiology, , 282 (1 ) ,G175-83 More Information

Zavros, Yana; Rieder, Gabriele; Ferguson, Amy; Samuelson, Linda C; Merchant, Juanita L (2002. ) Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology, , 122 (1 ) ,119-33

Zavros, Y; Paterson, A; Lambert, J; Shulkes, A (2000. ) Expression of progastrin-derived peptides and somatostatin in fundus and antrum of nonulcer dyspepsia subjects with and without Helicobacter pylori infection. Digestive diseases and sciences, , 45 (10 ) ,2058-64

Zavros, Y; Van Antwerp, M; Merchant, J L (2000. ) Use of flow cytometry to quantify mouse gastric epithelial cell populations. Digestive diseases and sciences, , 45 (6 ) ,1192-9

Ofori-Darko, E; Zavros, Y; Rieder, G; Tarlé, S A; Van Antwerp, M; Merchant, J L (2000. ) An OmpA-like protein from Acinetobacter spp. stimulates gastrin and interleukin-8 promoters. Infection and immunity, , 68 (6 ) ,3657-66

Grabau, B J; Zavros, Y; Hardy, K J; Shulkes, A (1999. ) Developmental regulation of gastric somatostatin secretion in the sheep. Endocrinology, , 140 (2 ) ,603-8

Zavros, Y; Fleming, W R; Shulkes, A (1999. ) Concurrent elevation of fundic somatostatin prevents gastrin stimulation by GRP. The American journal of physiology, , 276 (1 Pt 1 ) ,G21-7

Zavros, Y; Fleming, W R; Hardy, K J; Shulkes, A (1998. ) Regulation of fundic and antral somatostatin secretion by CCK and gastrin. The American journal of physiology, , 274 (4 Pt 1 ) ,G742-50

Zavros, Y; Shulkes, A (1997. ) Cholecystokinin (CCK) regulates somatostatin secretion through both the CCK-A and CCK-B/gastrin receptors in sheep. The Journal of physiology, , 505 ( Pt 3) ,811-21

Student Advising

Chang Xiao (Doctoral ) Advisor

Jessica Donnelly (Doctoral ) Advisor

Megan Payne (Master ) Advisor Status:Completed 2008

Philip Shin (Master ) Advisor Status:Completed 2008

Jason Martin (Master ) Advisor Status:Completed 2009

Sally Ogle (Other ) Preceptor

Jessica Donnelly (Other ) Lab Rotation Preceptor Status:Completed 2008

Michael Shumacher (Master ) Lab Rotation Preceptor Status:Completed 2008

Ambreesh Chawla (Undergrad ) Lab Rotation Preceptor Status:Completed 2008

Elise Demitrack (Doctoral ) Committee Member Status:Completed 06-2010

Aaron Marshall (Doctoral ) Committee Member Status:Completed

Heather Hale (Doctoral ) Committee Member Status:In Progress

Service

(Molecular and Cellular Physiology Faculty Search Committee ) Reviewer Type:Departmental Service Level:Department

(Molecular and Cellular Physiology Faculty Search Committee ) Co-Director Type:Departmental Service Level:Department

Curriculum Committee in Systems Biology and Physiology Graduate Program Committee Chair Type:Departmental Service Level:Department

(Qualifying exam committee ) Committee Member Type:University/College Service Level:Department

Gastroenterology: Average of 3 manuscripts reviewed per year Reviewer Type:Service to Professional Associations

(Ph.D. Thesis Examiner ) Reviewer Type:University/College Service Level:International 2009

American Journal of Physiology: average of 2 manuscripts reviewed / yr. Reviewer Type:Other Level:National

Mechanisms of Development: Average of 1 manuscript reveiwed/ yr Type:Other Level:National

Development: Average of 1 manuscript reviewed / yr Type:Other Level:National

Laboratory Investigation: Average of 1 manuscript reviewed/yr Type:Other Level:National

Agency for Science, Technology and Research (A*STAR), Singapore (Biomedical Sciences Research Grants ) Reviewer Type:Other Level:International

Professional Affiliation

I was reappointed as Assistant Professor in the Department of Molecular and Cellular Physiology

Resubmission of my R01 application was reviewed and was scored in this round of reviews. I have one more re-submission in which I am working towards. My goal here is to get the grant funded in the next review round.

Courses Taught

26-MCP-951 MOLECULAR PHYS I Level:Graduate

26-MCP-911 SEMINAR/JOUR CLUB Level:Graduate

26-MCP-912 SEMINAR/JOUR CLUB Level:Graduate

26-MCP-913 SEMINAR CLUB Level:Graduate

26-MCP-900 RESEARCH TECHNIQUES Level:Graduate

26-MCP-848 SPECIAL TOPICS PHYS Human Systems Physiology II Level:Graduate

26-MCP-874 RESEARCH CAREERS Level:Graduate

2008 Summer Undergraduate Research Fellowship (SURF) Level:Undergraduate

Contact Information

Academic - Office 4255 Medical Sciences Building
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0576
Phone: (513)558-2421
Fax: (513)558-5738
yana.zavros@uc.edu