Chad Zender, MD

Chad A Zender, MD

Professor; Associate Chief Medical Officer for UC Health

Medical Sciences Building

COM Oto H&N Oncologic Surgery - 0528

Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267


Bachelor of Science , Bowling Green State University Bowling Green, Ohio , 1997 (Biochemistry)

Medical Degree, Wright State University School of Medicine Dayton, Ohio, 2001

Positions and Work Experience

- Associate Chief Medical Officer, UC Health, Center of Excellence Leader, Head and Neck, UC Cancer Institute ,

UC Health Clinical Focus



American Board of Otolaryngology


Research Support

Grant: #RES512929-UC / TECG20180266 Investigators:Wise-Draper, Trisha; Zender, Chad 05-15-2019 -12-31-2019 Ohio Development Services Agency Determining hBD-3 as a valid biomarker in head and neck cancer Role:PI $20,000.00 Awarded Level:State of Ohio

Grant: #RES513922 / R01 DE025284- Investigators:Zender, Chad 02-01-2019 -09-30-2019 National Institute of Dental and Craniofacial Research Head Neck Cancer, beta-defensins, and immune responces Role:PI $8,550.00 Awarded Level:Federal

Grant: #RSG-19-111-01-CCE Investigators:Borchers, Michael; Hinrichs, Benjamin; Wise-Draper, Trisha; Zender, Chad 01-01-2020 -12-31-2023 American Cancer Society - National Chapter Harnessing the Natural Killer Cytotoxic Response in Head and Neck Cancer Role:Collaborator $792,000.00 Active Level:Private Non-Profit

Grant: #RES515013 / R21DE028416 Investigators:Tang, Alice; Zender, Chad 01-01-2020 -05-31-2020 National Institute of Dental and Craniofacial Research HBD-3: A novel factor orchestrating microbial persistence in suspicious oral lesions Role:Collaborator $4,391.00 Awarded Level:Federal


Peer Reviewed Publications

Clancy K.;Sozansky Lujan J.;Xia T.;Zender C.;Maronian N. (11-01-2019. )Outcomes of tracheoesophageal puncture in twice-radiated patients.American Journal of Otolaryngology - Head and Neck Medicine and Surgery, ,40 (6 ),

Li Y.;Awan M.J.;Chang T.;Lavertu P.;Zender C.;Rezaee R.;Fowler N.;Wasman J.;Avril N.E.;Chen N.;Machtay M.;Yao M. (04-01-2019. )Post-radiotherapy PET/CT for predicting treatment outcomes in head and neck cancer after postoperati.European Journal of Nuclear Medicine and Molecular Imaging, ,46 (4 ),794-800

Tamaki A.;Manzoor N.;Babajanian E.;Ascha M.;Rezaee R.;Zender C. (03-01-2019. )Clinical Significance of Sarcopenia among Patients with Advanced Oropharyngeal Cancer.Otolaryngology - Head and Neck Surgery (United States), ,160 (3 ),480-487

McSpadden R.;Zender C.;Eskander A. (01-01-2019. )AHNS series: Do you know your guidelines? Guideline recommendations for recurrent and persistent hea.Head and Neck, ,41 (1 ),7-15

Zender C.A.;Patel A.V.;Strohl M.;Melki S.;Maronian N. (01-01-2019. )The prefabricated supraclavicular artery flap in high-risk tracheal stenosis patients.Laryngoscope, ,

Kurlander D.E.;Melki S.;Joshi R.;Thuener J.;Li S.;Fowler N.;Zender C.;Rezaee R. (01-01-2019. )Preserving the branch to the vastus intermedius increases anterolateral thigh flap versatility.Laryngoscope, ,

Cervenka B.;Pipkorn P.;Fagan J.;Zafereo M.;Aswani J.;Macharia C.;Kundiona I.;Mashamba V.;Zender C.;Moore M. (01-01-2019. )Oral cavity cancer management guidelines for low-resource regions.Head and Neck, ,

Thuener J.E.;Clancy K.;Scher M.;Ascha M.;Harrill K.;Ahadizadeh E.;Rezaee R.;Fowler N.;Lavertu P.;Teknos T.;Zender C. (01-01-2019. )Impact of perioperative pain management protocol on opioid prescribing patterns.Laryngoscope, ,

Cervenka B.;Trudeau S.;Fagan J.;Zender C. (10-01-2018. )Reconstructive considerations in low and middle-income countries.Current opinion in otolaryngology & head and neck surgery, ,26 (5 ),340-346

Babajanian E.;Tamaki A.;Bordeaux J.;Honda K.;Zender C. (08-01-2018. )Clinical significance of tumor mitotic rate and lack of epidermal attachment in melanoma of the head.Head and Neck, ,40 (8 ),1691-1696

Zender C.;Clancy K.;Thuener J.;Mannion K. (06-01-2018. )Surgical outreach and microvascular surgery in developing countries.Oral Oncology, ,81 ,69-74

Patel A.;Thuener J.;Clancy K.;Ascha M.;Manzoor N.;Zender C. (03-01-2018. )Submental artery island flap versus free flap reconstruction of lateral facial soft tissue and parot.Oral Oncology, ,78 ,194-199

Tamaki A.;Miles B.A.;Lango M.;Kowalski L.;Zender C.A. (01-01-2018. )AHNS Series: Do you know your guidelines? Review of current knowledge on laryngeal cancer.Head and Neck, ,40 (1 ),170-181

Zender C.;Clancy K.;Melki S.;Li S.;Fowler N. (01-01-2018. )The impact of a head and neck microvascular fellowship program on otolaryngology resident training.Laryngoscope, ,128 (1 ),52-56

Rodin J.;Bar-Ad V.;Cognetti D.;Curry J.;Johnson J.;Zender C.;Doyle L.;Kutler D.;Leiby B.;Keane W.;Luginbuhl A. (01-01-2018. )A systematic review of treating recurrent head and neck cancer: A reintroduction of brachytherapy wi.Journal of Contemporary Brachytherapy, ,10 (5 ),454-462

Swendseid B.;Li S.;Thuener J.;Rezaee R.;Lavertu P.;Fowler N.;Zender C. (10-01-2017. )Incidence of facial nerve sacrifice in parotidectomy for primary and metastatic malignancies.Oral Oncology, ,73 ,43-47

Clancy K.;Melki S.;Awan M.;Li S.;Lavertu P.;Fowler N.;Yao M.;Rezaee R.;Zender C. (09-01-2017. )Outcomes of microvascular free tissue transfer in twice-irradiated patients.Microsurgery, ,37 (6 ),574-580

Lin S.;Melki S.;Lisgaris M.;Ahadizadeh E.;Zender C. (07-01-2017. )Post-operative MRSA infections in head and neck surgery.American Journal of Otolaryngology - Head and Neck Medicine and Surgery, ,38 (4 ),417-421

Awan M.;Lavertu P.;Zender C.;Rezaee R.;Fowler N.;Karapetyan L.;Gibson M.;Wasman J.;Faulhaber P.;Machtay M.;Yao M. (06-01-2017. )Post-treatment PET/CT and p16 status for predicting treatment outcomes in locally advanced head and .European Journal of Nuclear Medicine and Molecular Imaging, ,44 (6 ),988-997

Okoye C.;Bucher J.;Tatsuoka C.;Parikh S.;Oliveira G.;Gibson M.;Machtay M.;Yao M.;Zender C.;Dorth J. (03-01-2017. )Cardiovascular risk and prevention in patients with head and neck cancer treated with radiotherapy.Head and Neck, ,39 (3 ),527-532

Manzoor N.;Rezaee R.;Ray A.;Wick C.;Blackham K.;Stepnick D.;Lavertu P.;Zender C. (02-01-2017. )Contemporary management of carotid blowout syndrome utilizing endovascular techniques.Laryngoscope, ,127 (2 ),383-390

Clancy K.;Huwyler C.;Li S.;Otiti J.;Zender C.A. (01-01-2017. )The use of the submental island flap in reconstructing palatal and facial defects in a surgical camp.American Journal of Otolaryngology - Head and Neck Medicine and Surgery, ,38 (1 ),96-99

Wick C.;Rezaee R.;Wang T.;Garcia-Jarchow A.;Zender C.;Gibson M.;Yao M.;Lavertu P. (01-01-2017. )Use of concurrent chemoradiation in advanced staged (T4) laryngeal cancer.American Journal of Otolaryngology - Head and Neck Medicine and Surgery, ,38 (1 ),72-76

Fagan J.;Aswani J.;Otiti J.;Mushamba V.;Liyombo E.;Woodson G.;Weed D.;Zender C.;Mannion K.;Netterville J.;Wagner R.;Zafereo M. (12-01-2016. )Educational workshops with graduates of the University of Cape Town Karl Storz Head and Neck Surgery.SpringerPlus, ,5 (1 ),

Cheng O.;Tamaki A.;Rezaee R.;Zender C. (11-01-2016. )Laryngotracheal reconstruction with a prefabricated fasciocutaneous free flap for recurrent papillar.Head and Neck, ,38 (11 ),E2512-E2514

Scott J.;Thompson C.;Vyas R.;Honda K.;Zender C.;Rezaee R.;Lavertu P.;Koon H.;Cooper K.;Gerstenblith M. (07-01-2016. )Parotid melanoma of unknown primary.Journal of Cancer Research and Clinical Oncology, ,142 (7 ),1529-1537

DasGupta T.;Nweze E.;Yue H.;Wang L.;Jin J.;Ghosh S.;Kawsar H.;Zender C.;Androphy E.;Weinberg A.;McCormick T.;Jin G. (05-10-2016. )Human papillomavirus oncogenic E6 protein regulates human ?-defensin 3 (hBD3) expression via the tum.Oncotarget, ,7 (19 ),27430-27444

Yao M.;Woods C.;Lavertu P.;Fu P.;Gibson M.;Rezaee R.;Zender C.;Wasman J.;Sharma N.;Machtay M.;Savvides P. (04-01-2016. )Phase II study of erlotinib and docetaxel with concurrent intensity-modulated radiotherapy in locall.Head and Neck, ,38 ,E1770-E1776

Frankel J.;Rezaee R.;Harvey D.;McBeath E.;Zender C.;Lavertu P. (11-01-2015. )Use of negative pressure wound therapy with instillation in the management of cervical necrotizing f.Head and Neck, ,37 (11 ),E157-E160

Yao M.;Galanopoulos N.;Lavertu P.;Fu P.;Gibson M.;Argiris A.;Rezaee R.;Zender C.;Wasman J.;Machtay M.;Savvides P. (01-01-2015. )Phase II study of bevacizumab in combination with docetaxel and radiation in locally advanced squamo.Head and Neck, ,37 (11 ),1665-1671

Rodriguez C.;Adelstein D.;Rybicki L.;Savvides P.;Saxton J.;Koyfman S.;Greskovich J.;Yao M.;Scharpf J.;Lavertu P.;Wood B.;Burkey B.;Lorenz R.;Rezaee R.;Zender C.;Ives D. (01-01-2015. )Randomized phase III study of 2 cisplatin-based chemoradiation regimens in locally advanced head and.Head and Neck, ,37 (11 ),1583-1589

Liu Y.;Zender C. (11-01-2014. )Response to "which is better option for the treatment of large neck keloids? Free tissue transfer ve.American Journal of Otolaryngology - Head and Neck Medicine and Surgery, ,35 (6 ),829-830

Chen Y.;Chhabra N.;Liu Y.;Zender C. (01-01-2014. )Lateral arm microvascular free tissue reconstruction of a large neck keloid.American Journal of Otolaryngology - Head and Neck Medicine and Surgery, ,35 (4 ),514-516

Zender C.;Guo T.;Weng C.;Faulhaber P.;Rezaee R. (01-01-2014. )Utility of SPECT/CT for periparotid sentinel lymph node mapping in the surgical management of head a.American Journal of Otolaryngology - Head and Neck Medicine and Surgery, ,35 (1 ),12-18

Jaber J.J.;Zender C.A.;Mehta V.;Davis K.;Ferris R.L.;Lavertu P.;Rezaee R.;Feustel P.J.;Johnson J.T. (01-01-2014. )Multi-institutional investigation of the prognostic value of lymph nodel yield in advanced-stage ora.Head and Neck, ,36 (10 ),1446-1452

Manjila S.;Zender C.;Weaver J.;Rodgers M.;Cohen A. (07-01-2013. )Aneurysmal bone cyst within fibrous dysplasia of the anterior skull base: Continued intracranial ext.Child's Nervous System, ,29 (7 ),1183-1192

Schmitt A.;Zender C.;Bordeaux J. (05-01-2013. )A new oral anticoagulant in the setting of dermatologic surgery.Journal of the American Academy of Dermatology, ,68 (5 ),869-870

Wick C.;Rezaee R.;Zender C. (03-01-2013. )Piezoelectric BoneScalpel osteotomies in osteocutaneous free flaps.Laryngoscope, ,123 (3 ),618-621

Zender C.;Mehta V.;Pittman A.;Feustel P.;Jaber J. (07-01-2012. )Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction.Laryngoscope, ,122 (7 ),1474-1479

Yao M.;Lu M.;Savvides P.S.;Rezaee R.;Zender C.A.;Lavertu P.;Buatti J.M.;MacHtay M. (06-01-2012. )Distant metastases in head-and-neck squamous cell carcinoma treated with intensity-modulated radioth.International Journal of Radiation Oncology Biology Physics, ,83 (2 ),684-689

Jaber J.J.;Clark J.I.;Muzaffar K.;Ruggiero F.P.;Feustel P.J.;Frett M.J.;Zender C.A. (01-01-2011. )Evolving treatment strategies in thin cutaneous head and neck melanoma: 1 institution's experience.Head and Neck, ,33 (1 ),7-12

Pittman A.;Zender C. (09-01-2010. )Total maxillectomy.Operative Techniques in Otolaryngology - Head and Neck Surgery, ,21 (3 ),166-170

Mantravadi A.V.;Zender C.A. (09-01-2010. )Craniofacial approaches to the anterior skull base.Operative Techniques in Otolaryngology - Head and Neck Surgery, ,21 (3 ),181-187

Jaber J.J.;Ruggiero F.;Zender C.A. (09-01-2010. )Facial degloving approach to the midface.Operative Techniques in Otolaryngology - Head and Neck Surgery, ,21 (3 ),171-174

Ruggiero F.P.;Zender C.A. (06-01-2010. )Frontal sinus cranialization.Operative Techniques in Otolaryngology - Head and Neck Surgery, ,21 (2 ),143-146

Leonetti J.;Marzo S.;Zender C.;Porter R.;Melian E. (06-01-2010. )Temporal bone osteoradionecrosis after surgery and radiotherapy for malignant parotid tumors.Otology and Neurotology, ,31 (4 ),656-659

Marzo S.;Zender C.;Leonetti J. (10-01-2009. )Facial nerve schwannoma.Current Opinion in Otolaryngology and Head and Neck Surgery, ,17 (5 ),346-350

Leonetti J.P.;Zender C.A.;Vandevender D.;Marzo S.J. (04-01-2008. )Long-term results of microvascular free-tissue transfer reanimation of the paralyzed face: Three cas .Ear, Nose and Throat Journal, ,87 (4 ),

Schrementi M.;Ferreira A.;Zender C.;DiPietro L. (01-01-2008. )Site-specific production of TGF-? in oral mucosal and cutaneous wounds.Wound Repair and Regeneration, ,16 (1 ),80-86

Sitole S.;Zender C.A.;Ahmad A.Z.;Hammadeh R.;Petruzzelli G.J. (09-01-2007. )Lacrimal sac melanoma.Ophthalmic Plastic and Reconstructive Surgery, ,23 (5 ),417-419

Zender C.;Petruzzelli G. (04-01-2005. )Why do patients with head and neck squamous cell carcinoma experience distant metastases: Can they b.Current Opinion in Otolaryngology and Head and Neck Surgery, ,13 (2 ),101-104

Zender C.;Petruzzelli G. (01-01-2005. )Skin grafting in oral cavity reconstruction.Operative Techniques in Otolaryngology - Head and Neck Surgery, ,16 (1 SPEC. ISS. ),24-27

Zender C.;Petruzzelli G. (01-01-2003. )The skull base, paranasal sinuses, and related malignancies.Current Oncology Reports, ,5 (2 ),147-151

Provost T.;Juárez de Ku L.;Zender C.;Meserve L. (07-01-1999. )Dose- and age-dependent alterations in choline acetyltransferase (ChAT) activity, learning and memor.Progress in Neuro-Psychopharmacology and Biological Psychiatry, ,23 (5 ),915-928

Post Graduate Training and Education

2001-2002 Internship - General Surgery, Loyola University Chicago, ,Maywood, Illinois

2002-2006 Residency in Otolaryngology - Head and Neck Surgery , Loyola University of Chicago, ,Maywood, Illinois

2006-2007 Fellowship - Microvascular-Head and Neck Surgery , Vanderbilt University Medical Center, ,Nashville, Tennessee

Contact Information

Academic - Medical Sciences Building
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 513-558-4196
Fax: 513-558-5203