Erik Zhang

Erik Y Zhang

Research Scientist

Cardiovascular Rsrch Cntr


COM IM Pulmonary McCormack Lab - 0564


Ph. D.: City University of New York NYC, NY, 1998 (Biology)

B. S.: SUN YAT-SEN UNIVERSITY Guangzhou, China, 1984 (Botany)

Research and Practice Interests

Pathology are usually revealed as molecular insights of the diseased tissue. From analysis of TSC and LAM related gene expression arrays, we identified many potential biomarkers including most protein coding genes and lncRNAs. Those genes are differential expressed highly significantly between LAM nodules and normal tissues and they are subject to GSEA, network and pathway analysis. We also incorporate bio-pathways with our metabolomics data, and develop our working hypothesis.
The most direct validation comes from studies on the human samples. In addition to use PCR and Western Blotting, we are also looking tissue distribution and cellular localization of those targeting genes. To validate our working hypothesis further, we test all available and potential therapeutic means by using both in vitro and in vivo approaches with our established cell and animal models. Thus our studies may be translated to clinical applications efficiently.


Peer Reviewed Publications

Li, Xiangke; Liu, Xiaolei; Zhang, Linda; Li, Chenggang; Zhang, Erik; Ma, Wang; Fan, Qingxia; Yu, Jane J (2017. ) Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis.Oncotarget, , 8 (22 ) ,36628-36638 More Information

Li, Chenggang; Li, Na; Liu, Xiaolei; Zhang, Erik Y; Sun, Yang; Masuda, Kouhei; Li, Jing; Sun, Julia; Morrison, Tasha; Li, Xiangke; Chen, Yuanguang; Wang, Jiang; Karim, Nagla A; Zhang, Yi; Blenis, John; Reginato, Mauricio J; Henske, Elizabeth P; Yu, Jane J (2016. ) Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.JCI insight, , 1 (19 ) ,e86629 More Information

Rembold, C M; Zhang, E (2001. ) Localization of heat shock protein 20 in swine carotid artery. BMC physiology, , 1 ,10

Zhang, Erik Y; Stein, Raimund; Chang, Shaohua; Zheng, Yongmu; Zderic, Stephen A; Wein, Alan J; Chacko, Samuel (2004. ) Smooth muscle hypertrophy following partial bladder outlet obstruction is associated with overexpression of non-muscle caldesmon.The American journal of pathology, , 164 (2 ) ,601-12 More Information

Li, Chenggang; Zhou, Xiaobo; Sun, Yang; Zhang, Erik; Mancini, John D; Parkhitko, Andrey; Morrison, Tasha A; Silverman, Edwin K; Henske, Elizabeth P; Yu, Jane J (2013. ) Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology, , 49 (1 ) ,135-42 More Information

Khabibullin, Damir; Medvetz, Douglas A; Pinilla, Miguel; Hariharan, Venkatesh; Li, Chenggang; Hergrueter, Anja; Laucho Contreras, Maria; Zhang, Erik; Parkhitko, Andrey; Yu, Jane J; Owen, Caroline A; Huang, Hayden; Baron, Rebecca M; Henske, Elizabeth P (2014. ) Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells.Physiological reports, , 2 (8 ) , More Information

Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D; Kwiatkowski, David; Yu, Jane J (2014. ) Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.The Journal of experimental medicine, , 211 (1 ) ,15-28 More Information

Li, Chenggang; Zhang, Erik; Sun, Yang; Lee, Po-Shun; Zhan, Yongzhong; Guo, Yanan; Osorio, Juan C; Rosas, Ivan O; Xu, Kai-Feng; Kwiatkowski, David J; Yu, Jane J (2014. ) Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.PloS one, , 9 (10 ) ,e104809 More Information

Sun, Yang; Gallacchi, Dana; Zhang, Erik Y; Reynolds, Samuel B; Robinson, Lauren; Malinowska, Izabela A; Chiou, Terry T; Pereira, Ana M; Li, Chenggang; Kwiatkowski, David J; Lee, Po-Shun; Yu, Jane J (2014. ) Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology, , 51 (6 ) ,738-49 More Information

Sun, Yang; Zhang, Erik; Lao, Taotao; Pereira, Ana M; Li, Chenggang; Xiong, Li; Morrison, Tasha; Haley, Kathleen J; Zhou, Xiaobo; Yu, Jane J (2014. ) Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis.Hormones & cancer, , 5 (5 ) ,284-98 More Information

Sun, Y; Gu, X; Zhang, E; Park, M-A; Pereira, A M; Wang, S; Morrison, T; Li, C; Blenis, J; Gerbaudo, V H; Henske, E P; Yu, J J (2014. ) Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.Cell death & disease, , 5 ,e1231 More Information

Li, Jing; Csibi, Alfredo; Yang, Sun; Hoffman, Gregory R; Li, Chenggang; Zhang, Erik; Yu, Jane J; Blenis, John (2015. ) Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.Proceedings of the National Academy of Sciences of the United States of America, , 112 (1 ) ,E21-9 More Information

Li, Jing; Shin, Sejeong; Sun, Yang; Yoon, Sang-Oh; Li, Chenggang; Zhang, Erik; Yu, Jane; Zhang, Jianming; Blenis, John (2016. ) mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.Cancer research, , 76 (16 ) ,4816-27 More Information

Contact Information

Research - CVC 4962
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 5135589078