Jun-Ming Zhang

Jun-Ming Zhang

Professor and Vice Chair for Research

Medical Sciences Building

3413

COM Anesthesiology Zhang Lab - 0531

Medical Sciences Building
Room MSB 3413
Cincinnati, Ohio 45267

Professional Summary

Chronic pain conditions such as neuropathic pain are very common and can last a lifetime, persisting long after the initial damage to the nerve has healed. Chronic pain conditions involve complex, orchestrated changes in the sensory neurons and their synaptic targets. These changes include abnormal electrical activity, alterations in ion channels and transmitters, and sensitization of the pain pathways in the spinal cord and brain. We are currently investigating the role of cytokines in pain. We have developed new animal models involving compression and/or inflammation of the sensory ganglia. These models are particularly relevant to understanding low back pain. We have found that several inflammatory cytokines are upregulated in these models, with a time course that parallels the development of pain behaviors. Our aim is to understand the possible causal roles of these cytokines in abnormal pain states, with the ultimate goal of identifying new therapeutic targets for chronic pain. We use a number of techniques, including electrophysiology, animal behavior, microscopy, and biochemical and molecular methods. In a related project, we are also investigating the role and causes of the abnormal sympathetic sprouting into the sensory ganglia that exacerbates many chronic pain states and how sympathetic regulate local immune/inflammatory responses.  Recently, we have started several new projects: 1) determine whether and how high-fat diet and obsestiy may alter the responses to painful stimulation; 2) relationship between nerve injury initiated regeneration and the persistence of neuroapthic pain; 3) how steroid receptors change under pathological conditions and how such changes may affect theraputic efficacy of steroids used for managing inflammtory pain conditions.  Lastly, we have initiated several clinical studies to translate preclinical findings to clinical practice.  Specifically, we are interested in whether extended nerve block provides addtional benefit for patients with traumatic injury in lowing the risk of chronic pain; and how to improve efficacy of epidural steriods for managing low back pain.   

Education

Medical Degree, Shandong University 1988

Master's Degree, Peking Union Medical College & Chinese Academy of Medical Sciences 1991 (Neurophysiology)

Postdoctoral Associate, Yale University School of Medicine New Have, Connecticut, 1996 (Neurophysiology of Pain)

Research Support

Grant: #R01-NS-045594 Investigators:Zhang, Jun-Ming 05-01-2005 -04-30-2010 National Institute of Neurological Disorders and Stroke Study of Activity-Dependent Sympathetic Sprouting Role:PI $1,099,797.00 Closed Level:Federal

Grant: #R01 NS055860 Investigators:Zhang, Jun-Ming 12-15-2007 -11-30-2013 National Institute of Neurological Disorders and Stroke Neural and Chemical Basis of Pathologic Pain Role:PI $1,684,288.00 Active

Grant: #IUPUI4686278CINN / 5 R01 NS060853 Investigators:Zhang, Jun-Ming 07-17-2009 -06-30-2011 National Institute of Neurological Disorders and Stroke Sphingosine 1-Phosphate Receptors And Sensitization Of Sensory Neurons Role:PI $203,285.00 Active

Grant: #R01 NS045594 Investigators:Zhang, Jun-Ming 05-01-2010 -04-30-2015 National Institute of Neurological Disorders and Stroke Study of Activity-Dependent Sympathetic Sprouting Role:PI $1,301,421.00 Active

Grant: #2R01NS055860-06 Investigators:Zhang, Jun-Ming 02-01-2013 -01-31-2018 National Institute of Neurological Disorders and Stroke Neural And Chemical Basis Of Pathological Pain Role:PI $419,641.00 Active

Grant: #R01NS045594 Investigators:Zhang, Jun-Ming 02-01-2016 -01-31-2021 National Institute of Neurological Disorders and Stroke Study of Activity Dependant Sympathetic Sprouting Role:PI $488,274.90 Active Level:Federal

Grant: #FA8650-16-2-6G11 (Task under Master FA8650-15-2-6605) Investigators:Fortman II, James; Strong, Judith; Zhang, Jun-Ming 06-20-2016 -06-19-2017 Air Force Research Laboratory Extended Regional Anesthesia for Prevention of Chronic Pain after Traumatic Injury Role:PI $226,987.00 Active Level:Federal

Grant: #R01AR068989 Investigators:Zhang, Jun-Ming 07-15-2016 -06-30-2021 National Institute of Arthritis, Musculoskeletal and Skin Disease Steroids and Steroid Receptors in Low Back Pain Role:PI $339,944.00 Active

Publications

Peer Reviewed Publications

Xie, W.; Strong, J. A.; Zhang, J. M. (2017. )Active Nerve Regeneration with Failed Target Reinnervation Drives Persistent Neuropathic Pain .eNeuro, ,4 (1 ),

Zheng, W.; Xie, W.; Zhang, J.; Strong, J. A.; Wang, L.; Yu, L.; Xu, M.; Lu, L. (2003. )Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord .J Biol Chem, ,278 (48 ),48321-9

Xie, Wenrui; Strong, Judith A; Ye, Ling; Mao, Ju-Xian; Zhang, Jun-Ming (2013. )Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia.Pain, ,154 (8 ),1170-80

Xie, W.; Strong, J. A.; Meij, J. T.; Zhang, J. M.; Yu, L. (2005. )Neuropathic pain: early spontaneous afferent activity is the trigger .Pain, ,116 (3 ),243-56

Strong, Judith A; Xie, Wenrui; Bataille, Feguens J; Zhang, Jun-Ming (2013. )Preclinical studies of low back pain.Molecular pain, ,9 ,17

Xie, W. R.; Deng, H.; Li, H.; Bowen, T. L.; Strong, J. A.; Zhang, J. M. (2006. )Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia .Neuroscience, ,142 (3 ),809-22

Dong, Fei; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming (2012. )Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro.Anesthesiology, ,117 (5 ),1102-12

Wang, J. G.; Strong, J. A.; Xie, W.; Zhang, J. M. (2007. )Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons .Anesthesiology, ,107 (2 ),322-32

Xie, Wenrui; Strong, Judith A; Kays, Joanne; Nicol, Grant D; Zhang, Jun-Ming (2012. )Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion.Neuroscience letters, ,515 (1 ),61-5

Xie, W.; Strong, J. A.; Li, H.; Zhang, J. M. (2007. )Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block .J Neurophysiol, ,97 (1 ),492-502

Dong, Fei; Du, Yi-Ru; Xie, Wenrui; Strong, Judith A; He, Xi-Jing; Zhang, Jun-Ming (2012. )Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC.Neuroscience bulletin, ,28 (2 ),155-64

Li, H.; Xie, W.; Strong, J. A.; Zhang, J. M. (2007. )Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain .Anesthesiology, ,107 (3 ),469-77

Strong, Judith A; Xie, Wenrui; Coyle, Dennis E; Zhang, Jun-Ming (2012. )Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain.PloS one, ,7 (7 ),e40779

Wang, J. G.; Strong, J. A.; Xie, W.; Yang, R. H.; Coyle, D. E.; Wick, D. M.; Dorsey, E. D.; Zhang, J. M. (2008. )The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons .Mol Pain, ,4 (4 ),38

Xie, Wenrui; Strong, Judith A; Mao, Juxian; Zhang, Jun-Ming (2011. )Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse.Molecular pain, ,7 ,53

Xie, W.; Strong, J. A.; Zhang, J. M. (2009. )Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models .Neuroscience, ,160 (4 ),847-57

Du, Yi-Ru; Xiao, Yong; Lu, Zhuo-Min; Ding, Jing; Xie, Fang; Fu, Han; Wang, Yan; Strong, Judith A; Zhang, Jun-Ming; Chen, Jun (2011. )Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways.Biochemical and biophysical research communications, ,408 (1 ),32-7

Xie, W.; Strong, J. A.; Zhang, J. M. (2010. )Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion .Pain, ,151 (2 ),447-59

Li, Jing-Yi; Xie, Wenrui; Strong, Judith A; Guo, Qu-Lian; Zhang, Jun-Ming (2011. )Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.Regional anesthesia and pain medicine, ,36 (1 ),56-62

Xie, W.; Strong, J. A.; Mao, J.; Zhang, J. M. (2011. )Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse .Mol Pain, ,7 (2 ),53

Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming (2010. )Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion.Pain, ,151 (2 ),447-59

Li, J. Y.; Xie, W.; Strong, J. A.; Guo, Q. L.; Zhang, J. M. (2011. )Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain .Reg Anesth Pain Med, ,36 (1 ),56-62

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping (2009. )Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.Circulation, ,120 (11 Suppl ),S1-9

Xie, W.; Strong, J. A.; Kim, D.; Shahrestani, S.; Zhang, J. M. (2012. )Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion .Neuroscience, ,206 (8 ),212-23

Yang, Rui-Hua; Strong, Judith A; Zhang, Jun-Ming (2009. )NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons.Molecular pain, ,5 ,26

Dong, F.; Du, Y. R.; Xie, W.; Strong, J. A.; He, X. J.; Zhang, J. M. (2012. )Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC .Neurosci Bull, ,28 (2 ),155-64

Li, Jie; Xie, Wenrui; Zhang, Jun-Ming; Baccei, Mark L (2009. )Peripheral nerve injury sensitizes neonatal dorsal horn neurons to tumor necrosis factor-alpha.Molecular pain, ,5 ,10

Xie, W.; Strong, J. A.; Kays, J.; Nicol, G. D.; Zhang, J. M. (2012. )Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion .Neurosci Lett, ,515 (1 ),61-5

Zhang, Jun-Ming; Strong, Judith A (2008. )Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain. Sheng li xue bao : [Acta physiologica Sinica], ,60 (5 ),617-27

Strong, J. A.; Xie, W.; Coyle, D. E.; Zhang, J. M. (2012. )Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain .PLoS One, ,7 (7 ),e40779

Wang, Jun-Gang; Strong, Judith A; Xie, Wenrui; Yang, Rui-Hua; Coyle, Dennis E; Wick, Dayna M; Dorsey, Ericka D; Zhang, Jun-Ming (2008. )The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons.Molecular pain, ,4 ,38

Dong, F.; Xie, W.; Strong, J. A.; Zhang, J. M. (2012. )Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro .Anesthesiology, ,117 (5 ),1102-12

Zhang, Jun-Ming; Munir, Muhammad (2008. )Radicular low back pain: what have we learned from recent animal research?.Anesthesiology, ,108 (1 ),5-6

Li, C.; Chi, X. X.; Xie, W.; Strong, J. A.; Zhang, J. M.; Nicol, G. D. (2012. )Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor .J Neurophysiol, ,108 (5 ),1473-83

Liu, Bao-Gang; Dobretsov, Maxim; Stimers, Joseph R; Zhang, Jun-Ming (2008. )Tumor Necrosis Factor-? Suppresses Activation of Sustained Potassium Currents in Rat Small Diameter Sensory Neurons.The open pain journal, ,1 ,1

Xie, W.; Strong, J. A.; Ye, L.; Mao, J. X.; Zhang, J. M. (2013. )Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia .Pain, ,154 (8 ),1170-80

Munir, Muhammad A; Enany, Nasr; Zhang, Jun-Ming (2007. )Nonopioid analgesics.Anesthesiology clinics, ,25 (4 ),761-74, vi

Strong, J. A.; Xie, W.; Bataille, F. J.; Zhang, J. M. (2013. )Preclinical studies of low back pain .Mol Pain, ,9 (8 ),17

Li, Huiqing; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming (2007. )Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain.Anesthesiology, ,107 (3 ),469-77

Ye, L.; Xie, W.; Strong, J. A.; Zhang, J. M. (2014. )Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats .Anesthesiology, ,121 (3 ),632-43

Wang, Jun-Gang; Strong, Judith A; Xie, Wenrui; Zhang, Jun-Ming (2007. )Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons.Anesthesiology, ,107 (2 ),322-32

Xie, W.; Strong, J. A.; Zhang, J. M. (2015. )Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain .Neuroscience, ,291 (7 ),317-30

Zhang, Jun-Ming; An, Jianxiong (2007. )Cytokines, inflammation, and pain.International anesthesiology clinics, ,45 (2 ),27-37

Barbosa, C.; Tan, Z. Y.; Wang, R.; Xie, W.; Strong, J. A.; Patel, R. R.; Vasko, M. R.; Zhang, J. M.; Cummins, T. R. (2015. )Navbeta4 regulates fast resurgent sodium currents and excitability in sensory neurons .Mol Pain, ,11 (7 ),60

Xie, Wenrui; Strong, Judith Ann; Li, Huiqing; Zhang, Jun-Ming (2007. )Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block.Journal of neurophysiology, ,97 (1 ),492-502

Chen, S.; Xie, W. Strong, J.A.; Jiang, J.; Zhang, J-M (2015. )Progress in sympathetically-mediated pathological pain (review) .J Anesth Perioper Med, ,2 (7 ),216-225

Munir, Muhammad A; Enany, Nasr; Zhang, Jun-Ming (2007. )Nonopioid analgesics.The Medical clinics of North America, ,91 (1 ),97-111

Xie, W.; Chen, S.; Strong, J. A.; Li, A. L.; Lewkowich, I. P.; Zhang, J. M. (2016. )Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain .J Neurosci, ,36 (33 ),8712-25

Ackerman, William E; Zhang, Jun-Ming (2006. )Efficacy of stellate ganglion blockade for the management of type 1 complex regional pain syndrome. Southern medical journal, ,99 (10 ),1084-8

Ibrahim, S.I.A.; Strong, J.A.; Zhang, J-M. (2016. )Mineralocorticoid receptor, a promising target for improving management of low back pain by epidural steroid injections (review) .J Anesth Perioper Med, ,3 (33 ),177-184

Ackerman, William E; Zhang, Jun-Ming (2006. )Serum hs-CRP as a useful marker for predicting the efficacy of lumbar epidural steroid injections on pain relief in patients with lumbar disc herniations. The Journal of the Kentucky Medical Association, ,104 (7 ),295-9

Chen, S.; Xie, W.; Strong, J. A.; Jiang, J.; Zhang, J. M. (2016. )Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats .Eur J Pain, ,20 (7 ),1044-57

Xie, Wenrui; Strong, Judith A; Meij, Johanna T A; Zhang, Jun-Ming; Yu, Lei (2005. )Neuropathic pain: early spontaneous afferent activity is the trigger.Pain, ,116 (3 ),243-56

Xie, W.; Tan, Z. Y.; Barbosa, C.; Strong, J. A.; Cummins, T. R.; Zhang, J. M. (2016. )Upregulation of the sodium channel NaVbeta4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation .Pain, ,157 (4 ),879-91

Chien, Shelby Q; Li, Chunling; Li, Huiqing; Xie, Wenrui; Pablo, Carmelita S; Zhang, Jun-Ming (2005. )Sympathetic Fiber Sprouting in Chronically Compressed Dorsal Root Ganglia Without Peripheral Axotomy.Journal of neuropathic pain & symptom palliation, ,1 (1 ),19-23

Ackerman, William E; Munir, Muhammad A; Zhang, Jun-Ming; Ghaleb, Ahmed (2004. )Are diagnostic lumbar facet injections influenced by pain of muscular origin?.Pain practice : the official journal of World Institute of Pain, ,4 (4 ),286-91

Barbosa, C.; Xiao, Y.; Johnson, A. J.; Xie, W.; Strong, J. A.; Zhang, J. M.; Cummins, T. R. (2017. )FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons .Pflugers Arch, ,469 (2 ),195-212

Li, Ai-Hui; Zhang, Jun-Ming; Xie, Yi-Kuan (2004. )Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings.Brain research, ,1012 (1-2 ),154-9

Li, A. L.; Zhang, J. D.; Xie, W.; Strong, J. A.; Zhang, J. M. (2017. )Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models .Neurosci Bull, ,4 (1 ),

Zhang, Jun-Ming; Li, Huiqing; Munir, Muhammad A (2004. )Decreasing sympathetic sprouting in pathologic sensory ganglia: a new mechanism for treating neuropathic pain using lidocaine.Pain, ,109 (1-2 ),143-9

Simone, Donald A; Zhang, Xijing; Li, Jun; Zhang, Jun-Ming; Honda, Christopher N; LaMotte, Robert H; Giesler, Glenn J (2004. )Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.Journal of neurophysiology, ,91 (1 ),213-22

Song, Xue-Jun; Zhang, Jun-Ming; Hu, San-Jue; LaMotte, Robert H (2003. )Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators. Pain, ,104 (3 ),701-9

Dobretsov, Maxim; Hastings, Stephanie L; Romanovsky, Dmitry; Stimers, Joseph R; Zhang, Jun-Ming (2003. )Mechanical hyperalgesia in rat models of systemic and local hyperglycemia. Brain research, ,960 (1-2 ),174-83

Liu, Baogang; Li, Huiqing; Brull, Sorin J; Zhang, Jun-Ming (2002. )Increased sensitivity of sensory neurons to tumor necrosis factor alpha in rats with chronic compression of the lumbar ganglia. Journal of neurophysiology, ,88 (3 ),1393-9

Zhang, Jun-Ming; Li, Huiqing; Liu, Baogang; Brull, Sorin J (2002. )Acute topical application of tumor necrosis factor alpha evokes protein kinase A-dependent responses in rat sensory neurons. Journal of neurophysiology, ,88 (3 ),1387-92

Li, Huiqing; Liu, Bao-Gang; Dobretsov, Maxim; Brull, Sorin J; Zhang, Jun-Ming (2002. )Thermosensitivity of large primary sensory neurons. Brain research, ,926 (1-2 ),18-26

Homma, Yuko; Brull, Sorin J; Zhang, Jun-Ming (2002. )A comparison of chronic pain behavior following local application of tumor necrosis factor alpha to the normal and mechanically compressed lumbar ganglia in the rat. Pain, ,95 (3 ),239-46

Xie, W; Strong, J A; Zhang, J-M (2009. )Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models.Neuroscience, ,160 (4 ),847-57

Xie, W-R; Deng, H; Li, H; Bowen, T L; Strong, J A; Zhang, J-M (2006. )Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia.Neuroscience, ,142 (3 ),809-22

Munir, Muhammad A; Zhang, Junming; Ahmad, Mahmood (2004. )A modified needle-inside-needle technique for the ganglion impar block.Canadian journal of anaesthesia = Journal canadien d'anesthésie, ,51 (9 ),915-7

Dupont-Versteegden, Esther E; Houlé, John D; Dennis, Richard A; Zhang, Junming; Knox, Micheal; Wagoner, Gail; Peterson, Charlotte A (2004. )Exercise-induced gene expression in soleus muscle is dependent on time after spinal cord injury in rats.Muscle & nerve, ,29 (1 ),73-81

Munir, Muhammad A; Jaffar, Muhammad; Arshad, Muhammad; Akhter, M Shahab; Zhang, Junming (2003. )Reduced duration of muscle relaxation with rocuronium in a normocalcemic hyperparathyroid patient.Canadian journal of anaesthesia = Journal canadien d, ,50 (6 ),558-61

Hu, Sanjue; Song, Xuejun; Greenquist, Kenneth W; Zhang, Jun-Ming; LaMotte, Robert H (2001. )Protein kinase A modulates spontaneous activity in chronically compressed dorsal root ganglion neurons in the rat. Pain, ,94 (1 ),39-46

Dobretsov, M; Hastings, S L; Stimers, J R; Zhang, J M (2001. )Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. Journal of neuroscience methods, ,110 (1-2 ),9-15

Munir, M A; Saleem, M; Zhang, J M; Mancino, A K (2001. )Case of the month. Aberrant placement of central venous catheter in a thymic vein. The Journal of the Arkansas Medical Society, ,98 (4 ),112-4

Zhang, Jun-Ming; Homma, Yuko; Ackerman, Willaim E; Brull, Sorin J (2001. )Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat. Anesthesia and analgesia, ,93 (2 ),466-71, 4th contents

Liu, Bao-Gang; Zhuang, X L; Li, S T; Xu, G H; Brull, Sorin J; Zhang, Jun-Ming (2001. )Effects of bupivacaine and ropivacaine on high-voltage-activated calcium currents of the dorsal horn neurons in newborn rats. Anesthesiology, ,95 (1 ),139-43

Zhang, Jun-Ming; Li, Huiqing; Brull, Sorin J (2000. )Perfusion of the mechanically compressed lumbar ganglion with lidocaine reduces mechanical hyperalgesia and allodynia in the rat. Journal of neurophysiology, ,84 (2 ),798-805

Brull, Sorin J; Atanassoff, Peter G; Silverman, David G; Zhang, Jun-Ming; LaMotte, Robert H (1999. )Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosensory & motor research, ,16 (4 ),299-303

Atanassoff, Peter G; Brull, Sorin J; Zhang, Jun-Ming; Greenquist, Kenneth; Silverman, David G; LaMotte, Robert H (1999. )Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosensory & motor research, ,16 (4 ),291-8

Zhang, Jun-Ming; Song, Xuejun; LaMotte, Robert H (1999. )Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. Journal of neurophysiology, ,82 (6 ),3359-66

Song, Xue-Jun; Hu, San-Jue; Greenquist, Kenneth W; Zhang, Jun-Ming; LaMotte, Robert H (1999. )Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. Journal of neurophysiology, ,82 (6 ),3347-58

Zhang, Jun-Ming; Donnelly, David F; LaMotte, Robert H (1998. )Patch clamp recording from the intact dorsal root ganglion. Journal of neuroscience methods, ,79 (1 ),97-103

Zhang, Jun-Ming; Donnelly, David F; Song, Xuejun; LaMotte, Robert H (1997. )Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons. Journal of neurophysiology, ,78 (5 ),2790-4

Zhang, Jun-Ming; Song, Xuejun; LaMotte, Robert H (1997. )An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain, ,72 (1-2 ),51-7

Petersen, Marlen; Zhang, Jian-Feng; Zhang, Jun-Ming; LaMotte, Robert H (1996. )Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction. Pain, ,67 (2-3 ),391-7

Xie, Yikuan; Zhang, Jun-Ming; Petersen, Marlen; LaMotte, Robert H (1995. )Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat. Journal of neurophysiology, ,73 (5 ),1811-20

Zhang, Jun-Ming; Xu, Cheng-Tao; Chen, Juan (1992. )[The role of substance P in the modulation of myotension in paralyzed limbs after spinal transsection on rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, ,14 (6 ),413-8

Ding, Zhuofeng; Xu, Wei; Zhang, Jie; Zou, Wangyuan; Guo, Qulian; Huang, Changsheng; Liu, Chang; Zhong, Tao; Zhang, Jun-Ming; Song, Zongbin (2017. )Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain.International journal of cancer, ,140 (2 ),411-422

Barbosa, Cindy; Xiao, Yucheng; Johnson, Andrew J; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming; Cummins, Theodore R (2016. )FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons.Pflugers Archiv : European journal of physiology, ,

Xie, Wenrui; Chen, Sisi; Strong, Judith A; Li, Ai-Ling; Lewkowich, Ian P; Zhang, Jun-Ming (2016. )Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience, ,36 (33 ),8712-25

Xie, Wenrui; Tan, Zhi-Yong; Barbosa, Cindy; Strong, Judith A; Cummins, Theodore R; Zhang, Jun-Ming (2016. )Upregulation of the sodium channel NaV?4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation.Pain, ,157 (4 ),879-91

Barbosa, Cindy; Tan, Zhi-Yong; Wang, Ruizhong; Xie, Wenrui; Strong, Judith A; Patel, Reesha R; Vasko, Michael R; Zhang, Jun-Ming; Cummins, Theodore R (2015. )Nav?4 regulates fast resurgent sodium currents and excitability in sensory neurons.Molecular pain, ,11 ,60

Positions and Work Experience

1991 -1993 Lecturer, Chinese Academy of Medical Sciences, Beijing, China

1996 -1998 Associate Research Scientist, Study of chronic pain, Yale University School of Medicine, New Haven, Connecticut

1998 -2003 Assistant Professor, Physiology and pathology of pain, University of Arkansas for Medical Sciences , Little Rock, Arkansas

2003 -2005 Associate Professor, University of Arkansas for Medical Sciences , Little Rock, Arkansas

2005 -2008 Associate Professor of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio

2005 -2012 Director of Research, Developing research program in the Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio

2008 -To Present Professor of Anesthesiology, Conducting research on pain, University of Cincinnati College of Medicine, Cincinnati, Ohio

2012 -To Present Vice Chair for Research, Supervising research program in the Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio

Keywords

dorsal root ganglion, low back pain, inflammation, neuropathic pain, sympathetic, cytokines, chemokines

Research and Practice Interests

Physiology and pathophysiology of neuropathic pain, Sympathetic regulation of inflammatory response in pain, Mechanisms and management of low back pain, Sodium channels, ectopic discharges and pathological pain

Preferred Information

Professor and Vice Chair for Research, Zhang, Jun-Ming MD, MSc

Animal Protocol

05-01-20-02 , (Principal Investigator )Physiology and pathophysiology of pain Expiration Date: 01-12-2020

Contact Information

Academic - Medical Sciences Building
Room MSB 3413
Ohio, 45267
Phone: 513-558-2427
Fax: 513-558-0995
jun-ming.zhang@uc.edu