Peng Zhang

Peng Zhang


Professor of Chemistry & Materials Science

Crosley Tower


A&S Chemistry - 0172

Professional Summary

Chemistry & Materials Science
Research interests: Photodynamic therapy against bacteria and cancers; plasmonics; sensing; nanomaterials


PhD: University of Toronto Toronto, Canada, 1998 (Physical Chemistry)

Research and Practice Interests

Sensing; photodynamic therapy against bacteria and cancers; plasmonics; photon upconversion; nanomaterials

Abbreviated Publications

Peer Reviewed Publications

Park J, Tang H, and Zhang P. Differentiation of superoxide radical anions and singlet oxygen and their concurrent quantifications by nuclear magnetic resonance. Analytical Chemistry. 2023, 95(12), 5293-5299. 

Tessema E, Elakkat V, Chiu CF, Zheng JH, Chan KL, Shen CR, Zhang P, and Lu N. Recoverable Phospha-Michael Additions Catalyzed by a 4-N,N-Dimethylaminopyridinium Saccharinate Salt or a Fluorous Long-Chained Pyridine: Two Types of Reusable Base Catalysts. Molecules. 2021, 26, 4, 1159. 

Yu Z, Grasso MF, Cui X, Silva RN, Zhang P. Sensitive and label-free SERS detection of single-stranded DNA assisted by silver nanoparticles and gold-coated magnetic nanoparticles. ACS Applied Bio Materials. 2020, 3, 5, 2626-2632. 

Smith ME, Stastny AL, Lynch J, Yu Z, Zhang P, Heineman WR. Indicator dyes and catalytic nanoparticles for irreversible visual hydrogen sensing. Analytical Chemistry. 2020, 92, 15, 10651–10658. 

Smith ME, Stastny AL, Lynch J, Yu Z, Zhang P, Heineman WR. Indicator dyes and catalytic nanoparticles for irreversible visual hydrogen sensing. Analytical Chemistry. 2020, 92, 15, 10651–10658. 

Barker N, Taylor S, Ferguson E, Krause J, Oliver A, Connick W, Zhang P. Water’s role in polymorphic Platinum(II) complexes. Inorganic Chemistry. 2021, 60, 19, 14731–14743.

Vijayan AN, Refaei MA, Silva RN, Tsang P, and Zhang P. Detection of Sortase A and identification of its inhibitors by paramagnetic nanoparticle-assisted nuclear relaxation. Analytical Chemistry. 2021, 93, 46, 15430-15437. 

Silva RN, Vijayan AN, Westbrook E, Yu Z, Zhang P. Nanoparticle assisted nuclear relaxation-based oligonucleotide detection. Anal Chim Acta. 2019, 1062:118-123.

Vijayan AN, Liu, Z, Zhao H, Zhang P. Nicking enzyme-assisted signal-amplifiable Hg2+ detection using upconversion nanoparticles. Anal Chim Acta. 2019, 1072:75-80. 

Yu Z, Grasso MF, Sorensen HH, Zhang P. Ratiometric SERS detection of polycyclic aromatic hydrocarbons in soil assisted by β-cyclodextrin modified Au nanoparticles. Microchim Acta. 2019, 186:391-398.

E.G. Westbrook, P. Zhang. Plasmon-enhanced triplet-triplet annihilation upconversion of post-modified polymeric acceptors. Dalton Trans. 47(26):8638-8645 (2018). 

Z. Tian, M. Crowe, L. Shao, P. Zhang, L. Zhang, Q. Zhao, J. Diao. Interface colloidal deposition of nanoparticle wire structures. Particle and Particle Systems Characterization. 35, 1800098 (2018).

N. Wijesiri, Z. Yu, H. Tang, P. Zhang. Antifungal photodynamic inactivation against dermatophyte Trichophyton rubrum using nanoparticle-based hybrid photosensitizers. Photodiagnosis Photodyn Ther. 202-208 (2018).

Z. Yu, M.E. Smith, J. Zhang, Y. Zhou, P. Zhang. Determination of trichloroethylene by using self-referenced SERS and gold-core/silver-shell nanoparticles. Microchim Acta. 185(7):330-336 (2018).

P. Wang, H. Tang, P. Zhang. Highly efficient and biocompatible nanoparticle-based photosensitizer for treatment of acne vulgaris. Nanomedicine. 13(20):2629-2636 (2018). 

T. Ozkaya Ahmadov, P. Wang, H. Zhao, P. Zhang*. Magnetic Relaxation-Based Sensing of Phosphate Ion. Talanta. 162, 256-260 (2017).

C. Lee, P. Wang, M. A. Gaston, A. A. Weiss, P. Zhang*. Plasmonics-Based Detection of Virus Using Sialic Acid Functionalized Gold Nanoparticles. Methods Mol. Biol. 1571, 109-116 (2017).

N. Wijesiri, T. Ozkaya-Ahmadov, P. Wang, J. Zhang, H. Tang, X. Yu, N. Ayres, P. Zhang*. Photodynamic Inactivation of MRSA Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer Functionalized Gold Nanoparticles. ACS Omega. 2(9), 5364-5369 (2017). 

T. Ozkaya Ahmadov, R. Ding, J. Zhang, P. Wang, H. Tang, P. Zhang*. Silver Nanoparticle-Enhanced Hybrid Photosensitizer for Photoinactivation of Multidrug-Resistant Staphylococcus aureus (MRSA). RSC Advances.  6, 54318-54321 (2016).

P. Wang, H. Tang, P. Zhang*. Plasmonic Nanoparticle-based Hybrid Photosensitizers with Broadened Excitation Profile for Photodynamic Therapy of Cancer Cells. Sci. Rep.  6, 34981 (2016). 

R. Ding, X. Yu, P. Wang, J. Zhang, Y. Zhou, X. Cao, H. Tang, N. Ayres, P. Zhang*. Hybrid photosensitizer based on amphiphilic block copolymer stabilized silver nanoparticles for highly efficient photodynamic inactivation of bacteria. RSC Advances.  6, 20392-20398 (2016).

B. Hu, X. Cao, T. Ozkaya Ahmadov, H. Tang, P. Zhang*. Light-Harvesting Photosensitizers for Photodynamic Inactivation of Bacteria under Both Visible and Near-Infrared Excitations. Chemistry - An Asian Journal.  11, 1092-1097 (2016).

P. Joshi, P. Zhang*. Facile capture of conjugated polymer nanodots in mesoporous silica nanoparticles to facilitate surface modification. J. Materials Science. 50(10), 3597-3603, (2015).

C. Shi,* P. Zhang*. Role of MgO over γ-Al2O3-supported Pd catalysts for carbon dioxide reforming of methane. Appl. Catal. B: Environmental. V170-171, 43-52 (2015). 

Y. Zhou, R. Ding, P. Joshi, P. Zhang*. Quantitative SERS measurements with embedded internal reference. Analytica Chimica Acta. 874, 49-53 (2015). 

X. Cao, B. Hu, R. Ding, P. Zhang*. Plasmon-enhanced Homogeneous and Heterogeneous Triplet-Triplet Annihilation by Gold Nanoparticles. PhysChemChemPhys. 17, 14479-14483 (2015). 

T. O. Ahmadov, P. Joshi, J. Zhang, K. Nahan, J. Caruso, P. Zhang*. Paramagnetic Relaxation Based Biosensor for Selective Dopamine Detection. Chem. Comm. 51, 11425-11428 (2015). 

P. Joshi, T. O. Ahmadov, P. Wang, P. Zhang*. Singlet oxygen generation under NIR light and visible light excitations of photosensitizers on upconversion nanoparticle surface. RSC Advances. 5, 67892-67895 (2015).

J. Zhang, P. Joshi, Y. Zhou, R. Ding, P. Zhang*. Quantitative SERS-based DNA detection assisted by magnetic microspheres. Chem. Comm. 51, 15284-6 (2015). 

C. Lee, P. Zhang*. Highly stable gelatin layer-protected gold nanoparticles as surface-enhanced Raman scattering substrates. J. Nanoscience and Nanotechnology. 14, 4325-30 (2014).

Y. Zhou, P. Zhang*. Simultaneous SERS and surface-enhanced fluorescence from dye-embedded metal core-shell nanoparticles. PhysChemChemPhys. 16 (19), 8791 - 8794 (2014).

P. Wang, P. Joshi, A. Alazemi, P. Zhang*. Upconversion nanoparticle-based ligase-assisted method for specific and sensitive detection of T790M mutation in epidermal growth factor receptor. Biosens. Bioelectron. 62, 120-126 (2014).

B. Hu, X. Cao, K. Nahan, J. Caruso, H. Tang,* P. Zhang*. Surface Plasmon-Photosensitizer Resonance Coupling: An Enhanced Singlet Oxygen Production Platform for Broad-Spectrum Photodynamic Inactivation of Bacteria. J. Mater. Chem. B. 2, 7073-7081 (2014).

P. Joshi, Y. Zhou, Tevhide Ozkaya Ahmadov, P. Zhang*. Quantitative SERS-based detection using Ag-Fe3O4 nanocomposites with internal reference. J. Mater. Chem. C.  2, 9964-9968 (2014).

P. Wang, P. Zhang*. Upconversion luminescence resonance energy transfer-based ligase-assisted method for specific and sensitive detection of V600E mutation in BRAF gene.  RSC Advances. 4, 56235-56240 (2014).

Xinjun Yu, Xian Cao, Xiaoping Chen, Neil Ayres,* P. Zhang*. Triplet-Triplet Annihilation Upconversion from Rationally Designed Polymeric Emitters with Tunable Inter-Chromophore Distances.  Chem. Comm. 51, 588 (2015).

B. Hu, X. Cao, P. Zhang*. Selective Colorimetric Detection of Glutathione Based on Quasi-Stable Gold Nanoparticles Assembly. New J. Chem. 37, 3853-3856 (2013).More Information

B. Hu, X. Cao, P. Zhang*. Dual control of interparticle forces in gold nanoparticles assembly. ChemPlusChem.78(6), 506-514 (2013). doi:10.1002/cplu.201300091

Y. Zhou, C. Lee, J. Zhang, P. Zhang*. Engineering versatile SERS-active nanoparticles by embedding reporters between Au-core/Ag-shell through layer-by-layer deposited polyelectrolytes. J. Mater. Chem. C. 1(23), 3695 – 3699 (2013). DOI: 10.1039/C3TC30561A.

C. Lee, P. Zhang*. Facile synthesis of gelatin-protected silver nanoparticles for SERS applications. J. Raman Spectroscopy. 44, 823-826 (2013). DOI: 10.1002/jrs.4304.

X. Cao, B. Hu, P. Zhang*. High Upconversion Efficiency from Hetero Triplet-Triplet Annihilation in Multi-Acceptor Systems. J. Phys. Chem. Letters. 4, 2334-2338 (2013). DOI: 10.1021/jz041213w.

P. Wang, T. Ozkaya Ahmadov, C. Lee, P. Zhang*. Ligase-assisted signal-amplifiable DNA detection using upconversion nanoparticles. RSC Advances. 3(37), 16326-16329 (2013). DOI: 10.1039/c3ra42421a.

Effect of a second metal (Y, K, Ca, Mn or Cu) addition on the carbon dioxide reforming of methane over nanostructured palladium catalysts.C. Shi, P. Zhang. Appl. Catal. B: Environmental. V115-116, 190 (2012).

N. Liu, M. Gong, P. Zhang, L. Li, W. Li, R. Lee. Silver-embedded zeolite crystals as substrates for surface-enhanced Raman scattering. J. Mater. Sci.  46, 3162-8 (2011).

W. Li, X. Miao, T. S. Luk, P. Zhang. Enormous average enhancement factors from SERS-tags of TiO2-core mixed metal-shell nanoparticles. J. Phys. Chem. C.115, 3318 (2011).

W. Li, J. Zhang, Y. Zhou, P. Zhang. Highly enhanced fluorescence of fluorophores inside a metallic nanocavity. Chem. Comm. 47(20), 5834-6 (2011).

M. Kumar, P. Zhang. Highly Sensitive and Selective Label-Free Optical Detection of Mercuric Ions Using Photon Upconverting Nanoparticles. Biosens. Bioelectron. 25, 2431 (2010).

H. Tang, P. Zhang, T.L. Kieft, S.J. Ryan, S.M. Baker, W.P. Wiesmann, S. Rogelj. Antibacterial action of a novel functionalized chitosan-arginine against gram-negative bacteria. Acta Biomaterialia. 6(7), 2562 (2010).

W. Li, Y. Guo, K. McGill, P. Zhang. A facile synthesis of Ag nanoparticles for detection of Mercury (II) ion with high sensitivity and selectivity. New J. Chem. 34, 1148 (2010)

W. Li, Y. Guo and P. Zhang. A General Approach to Prepare TiO2-core Gold-shell Nanoparticles as SERS-tags. J. Phys. Chem. C. 114 (16), 7263 (2010)

W. Li, Y. Guo, P. Zhang. SERS-Active Silver Nanoparticles Prepared by a Simple and Green Method. J. Phys. Chem. C. 114, 6413 (2010).

Y. Guo, S. Rogelj, P. Zhang. Rose Bengal-decorated silica nanoparticles as photosensitizers for inactivation of Gram(+)-bacteria. Nanotechnology 21, 065102 (2010).

M. Kumar, P. Zhang. Highly sensitive and selective label-free optical detection of DNA hybridization based on photon upconverting nanoparticles. Langmuir 25(11), 6024, (2009).

P. Zhang, Y. Guo. Surface-enhanced Raman scattering using metal nanoshells. J. Am. Chem. Soc.131 (11), 3808 (2009).

M. Kumar, Y. Guo, P. Zhang. Highly sensitive and selective oligonucleotide sensor for sickle cell disease gene using photon upconverting nanoparticles. Biosens. Bioelectron. 24, 1522 (2009).

Y. Guo, M. Kumar, P. Zhang. Nanoparticle-based photosensitizers under CW infrared excitation. Chem. Materials. 19(25), 6071, (2007).

P. Zhang, W. Steelant, M. Kumar, M. Scholfield. Versatile photosensitizers for photodynamic therapy at infrared excitation. J. Am. Chem. Soc.129 (15), 4526 (2007).

P. Zhang, S. Rogelj, K. Nguyen, D. Wheeler. Design of highly sensitive and specific nucleotide sensor based on photon upconverting particles. J. Am. Chem. Soc.128 (38), 12410 (2006).

P. Zhang, S. Smith, G. Rumble and M. Himmel. Direct imaging of surface-enhanced Raman scattering in the near field. Langmuir 21, 520, (2005).

Honors and Awards

04-2021 University of Cincinnati, Emerging Entrepreneurship Faculty Award University of Cincinnati Status:Recipient Level:University Type:Recognition

09-2023 -09-2026 International Chair Professor National Taipei University of Technology Status:Recipient Level:International Type:Recognition


Nanomaterials, sensing, fluorescence, Raman, upconversion, photo therapy, ultrasound, antibacterial, NMR relaxation

Patents and Inventions

US Patent # 9,999,225 B2 Silver nanoparticle-enhanced photosensitizers as antibacterial and antibiofilm agents. 2018

US Patent # 7,811,830. Photosensitizers for photodynamic therapy at infrared excitation. 2010

US Patent # 7,332,351. Method for making nanoparticles. 2008

US Patent # 6,924,116. Method for identifying cells. 2005

US Patent # 6,548,264. Coated nanoparticles. 2003