Yi Zheng

Yi Zheng , PhD

Professor-Affiliate

Co-Director, Cincinnati Children's Cancer and Blood Diseases Institute, Director, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Affiliate Faculty Cancer Biology

Cincinnati Children's Hospital
Phone 513-636-0595
Email Yi.Zheng@cchmc.org

Publications

Peer Reviewed Publications

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi (2010. ) Rho GTPases in hematopoiesis and hemopathies.Blood, , 115 (5 ) ,936-47 More Information

Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy (2006. ) Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 26 (13 ) ,3390-5 More Information

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A (2007. ) Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.Cancer cell, , 12 (5 ) ,467-78 More Information

Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi (2014. ) Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.Chemistry & biology, , 21 (12 ) ,1618-28 More Information

Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy (2012. ) Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (48 ) ,17251-61 More Information

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A (2012. ) Signaling and cytoskeletal requirements in erythroblast enucleation.Blood, , 119 (25 ) ,6118-27 More Information

Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun (2012. ) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.Molecular pharmacology, , 81 (6 ) ,811-9 More Information

Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C (2011. ) Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.Blood, , 118 (19 ) ,5235-45 More Information

Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi (2011. ) Cdc42 regulates extracellular matrix remodeling in three dimensions.The Journal of biological chemistry, , 286 (42 ) ,36469-77 More Information

Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I (2011. ) Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility.Journal of virology, , 85 (20 ) ,10487-98 More Information

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun (2019. ) Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , 49 (1 ) ,92-107 More Information

Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi (2011. ) R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.The Journal of biological chemistry, , 286 (27 ) ,24068-78 More Information

Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina (2018. ) LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.Genome biology, , 19 (1 ) ,189 More Information

Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut (2010. ) Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.Nature medicine, , 16 (10 ) ,1141-6 More Information

Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang (2018. ) Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.Cancer discovery, , 8 (11 ) ,1438-1457 More Information

Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A (2018. ) Towards increasing shelf life and haemostatic potency of stored platelet concentrates.Current opinion in hematology, , 25 (6 ) ,500-508 More Information

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi (2010. ) Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.Haematologica, , 95 (1 ) ,27-35 More Information

Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi (2018. ) Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.Leukemia, , More Information

Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A (2009. ) Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766.Haematologica, , 94 (7 ) ,1011-5 More Information

Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut (2018. ) Aging alters the epigenetic asymmetry of HSC division.PLoS biology, , 16 (9 ) ,e2003389 More Information

Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping (2008. ) Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling.Cell cycle (Georgetown, Tex.), , 7 (21 ) ,3314-9 More Information

Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi (2018. ) A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells.Leukemia, , 32 (9 ) ,2041-2046 More Information

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C (2008. ) Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Cancer cell, , 13 (6 ) ,483-95 More Information

Cai, Xiongwei; Zheng, Yi; Speck, Nancy A (2018. ) A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells.Journal of visualized experiments : JoVE, , (138 ) , More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2018. ) Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 9 (1 ) ,670 More Information

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T (2018. ) TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis.Cell reports, , 22 (5 ) ,1250-1262 More Information

Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi (2007. ) Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.Proceedings of the National Academy of Sciences of the United States of America, , 104 (12 ) ,5091-6 More Information

Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi (2018. ) Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.Methods in molecular biology (Clifton, N.J.), , 1821 ,257-266 More Information

Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A (2006. ) Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.Blood, , 108 (6 ) ,2087-94 More Information

Cai, Xiongwei; Zhou, Xuan; Zheng, Yi (2018. ) In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells.Methods in molecular biology (Clifton, N.J.), , 1821 ,247-256 More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2017. ) Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 8 (1 ) ,2099 More Information

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut (2017. ) Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.Cell reports, , 18 (11 ) ,2608-2621 More Information

Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A (2005. ) Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.Nature medicine, , 11 (8 ) ,886-91 More Information

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T (2017. ) Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.Nature immunology, , 18 (2 ) ,236-245 More Information

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying (2005. ) MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.Molecular and cellular biology, , 25 (1 ) ,60-5 More Information

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A (2015. ) Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation.Nature communications, , 6 ,5914 More Information

Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun (2018. ) Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.Journal of immunology (Baltimore, Md. : 1950), , 200 (7 ) ,2313-2326 More Information

Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy (2013. ) Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling.Glia, , 61 (11 ) ,1906-21 More Information

Yang, Yingying; Dong, Panpan; Zhao, Jing; Zhou, Wei; Zhou, Yonghua; Xu, Yongliang; Mei, Congjin; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi (2018. ) PKC?/? regulates Th17 differentiation and house dust mite-induced allergic airway inflammation.Biochimica et biophysica acta, , 1864 (3 ) ,934-941 More Information

Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong (2018. ) Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.Respiratory research, , 19 (1 ) ,27 More Information

Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi (2013. ) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.Proceedings of the National Academy of Sciences of the United States of America, , 110 (8 ) ,3155-60 More Information

Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi (2017. ) RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance.Stem cell reports, , 9 (6 ) ,1961-1975 More Information

Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A (2012. ) Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.Blood, , 120 (4 ) ,800-11 More Information

Guo, Fukun; Zheng, Yi (2017. ) Vav1: Friend and Foe of Cancer.Trends in cell biology, , 27 (12 ) ,879-880 More Information

Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei (2017. ) YAP/TAZ-CDC42 signaling regulates vascular tip cell migration.Proceedings of the National Academy of Sciences of the United States of America, , 114 (41 ) ,10918-10923 More Information

Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C; Wunderlich, Mark; Hochstetler, Cindy L; Duan, Xin; Liu, Wei; Orr, Emily; Grimes, H Leighton; Mulloy, James C; Zheng, Yi (2017. ) The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.Blood, , 130 (11 ) ,1336-1346 More Information

Williams, David A; Zheng, Yi; Cancelas, Jose A (2008. ) Rho GTPases and regulation of hematopoietic stem cell localization.Methods in enzymology, , 439 ,365-93 More Information

Kalim, Khalid W; Zhang, Shuangmin; Chen, Xiaoyi; Li, Yuan; Yang, Jun-Qi; Zheng, Yi; Guo, Fukun (2017. ) mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.PloS one, , 12 (8 ) ,e0183266 More Information

Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi (2007. ) Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.Blood, , 110 (12 ) ,3853-61 More Information

Hato, Takashi; Winfree, Seth; Day, Richard; Sandoval, Ruben M; Molitoris, Bruce A; Yoder, Mervin C; Wiggins, Roger C; Zheng, Yi; Dunn, Kenneth W; Dagher, Pierre C (2017. ) Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures.Journal of the American Society of Nephrology : JASN, , 28 (8 ) ,2420-2430 More Information

Sinagoga, Katie L; Stone, William J; Schiesser, Jacqueline V; Schweitzer, Jamie I; Sampson, Leesa; Zheng, Yi; Wells, James M (2017. ) Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.Development (Cambridge, England), , 144 (13 ) ,2402-2414 More Information

Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M (2019. ) Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.Scientific reports, , 9 (1 ) ,11666 More Information

El Zowalaty, Ahmed E; Li, Rong; Zheng, Yi; Lydon, John P; DeMayo, Francesco J; Ye, Xiaoqin (2017. ) Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice.Endocrinology, , 158 (7 ) ,2168-2178 More Information

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi (2010. ) Rho GTPases in hematopoiesis and hemopathies.Blood, , 115 (5 ) ,936-47 More Information

Qiu, Sugan; Fan, Xiaolin; Yang, Yingying; Dong, Panpan; Zhou, Wei; Xu, Yongliang; Zhou, Yonghua; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi (2017. ) Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice.PloS one, , 12 (6 ) ,e0179565 More Information

Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying (2019. ) Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.Haematologica, , More Information

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun (2019. ) Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation.Journal of leukocyte biology, , More Information

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A (2007. ) Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.Cancer cell, , 12 (5 ) ,467-78 More Information

Li, Jingjing; Miao, Lianjie; Zhao, Chen; Shaikh Qureshi, Wasay Mohiuddin; Shieh, David; Guo, Hua; Lu, Yangyang; Hu, Saiyang; Huang, Alice; Zhang, Lu; Cai, Chen-Leng; Wan, Leo Q; Xin, Hongbo; Vincent, Peter; Singer, Harold A; Zheng, Yi; Cleaver, Ondine; Fan, Zhen-Chuan; Wu, Mingfu (2017. ) CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane.Development (Cambridge, England), , 144 (9 ) ,1635-1647 More Information

Filippi, Marie-Dominique; Harris, Chad E; Meller, Jarek; Gu, Yi; Zheng, Yi; Williams, David A (2004. ) Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.Nature immunology, , 5 (7 ) ,744-51 More Information

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A (2019. ) The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors.Nature communications, , 10 (1 ) ,46 More Information

Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy (2006. ) Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 26 (13 ) ,3390-5 More Information

Akbar, Huzoor; Duan, Xin; Saleem, Saima; Davis, Ashley K; Zheng, Yi RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets.PloS one, , 11 (9 ) ,e0163227 More Information

Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong (2019. ) ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.Haematologica, , More Information

Barry, David M; Koo, Yeon; Norden, Pieter R; Wylie, Lyndsay A; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D Berfin; Zheng, Yi; Cobb, Melanie H; Davis, George E; Cleaver, Ondine (2016. ) Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II.Circulation research, , 119 (7 ) ,810-26 More Information

Zandvakili, I; Lin, Y; Morris, J C; Zheng, Y (2017. ) Rho GTPases: Anti- or pro-neoplastic targets?.Oncogene, , 36 (23 ) ,3213-3222 More Information

Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi (2019. ) KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals.Experimental hematology, , More Information

Imai, Fumiyasu; Ladle, David R; Leslie, Jennifer R; Duan, Xin; Rizvi, Tilat A; Ciraolo, Georgianne M; Zheng, Yi; Yoshida, Yutaka (2016. ) Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 36 (21 ) ,5724-35 More Information

Palazzo, A; Bluteau, O; Messaoudi, K; Marangoni, F; Chang, Y; Souquere, S; Pierron, G; Lapierre, V; Zheng, Y; Vainchenker, W; Raslova, H; Debili, N (2016. ) The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.Journal of thrombosis and haemostasis : JTH, , 14 (12 ) ,2524-2535 More Information

Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi (2019. ) Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection.Cells, , 8 (10 ) , More Information

Nohata, Nijiro; Uchida, Yutaka; Stratman, Amber N; Adams, Ralf H; Zheng, Yi; Weinstein, Brant M; Mukouyama, Yoh-Suke; Gutkind, J Silvio (2016. ) Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.Developmental biology, , 411 (2 ) ,183-194 More Information

O'Hayre, M; Inoue, A; Kufareva, I; Wang, Z; Mikelis, C M; Drummond, R A; Avino, S; Finkel, K; Kalim, K W; DiPasquale, G; Guo, F; Aoki, J; Zheng, Y; Lionakis, M S; Molinolo, A A; Gutkind, J S (2016. ) Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G?13/RhoA axis in B cells.Oncogene, , 35 (29 ) ,3771-80 More Information

Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun (2019. ) Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma.Frontiers in oncology, , 9 ,958 More Information

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T (2020. ) Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.Nature immunology, , 21 (5 ) ,535-545 More Information

Sampson, Leesa L; Davis, Ashley K; Grogg, Matthew W; Zheng, Yi (2016. ) mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 30 (3 ) ,1263-75 More Information

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Guo, F; Li, J; Zhang, S; Du, W; Amarachintha, S; Sipple, J; Phelan, J; Grimes, H L; Zheng, Y; Pang, Q (2014. ) mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression.Leukemia, , 28 (1 ) ,203-6 More Information

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I (2018. ) Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy.International journal of particle therapy, , 5 (1 ) ,40-48 More Information

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Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi (2013. ) RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors.The Journal of experimental medicine, , 210 (11 ) ,2371-85 More Information

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Barry, David M; Xu, Ke; Meadows, Stryder M; Zheng, Yi; Norden, Pieter R; Davis, George E; Cleaver, Ondine (2015. ) Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice.Development (Cambridge, England), , 142 (17 ) ,3058-70 More Information

Guo, F; Li, J; Du, W; Zhang, S; O'Connor, M; Thomas, G; Kozma, S; Zingarelli, B; Pang, Q; Zheng, Y (2013. ) mTOR regulates DNA damage response through NF-?B-mediated FANCD2 pathway in hematopoietic cells.Leukemia, , 27 (10 ) ,2040-2046 More Information

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian (2020. ) Role of c-Myc haploinsufficiency in the maintenance of HSCs.Blood, , More Information

Zandvakili, Inuk; Davis, Ashley Kuenzi; Hu, Guodong; Zheng, Yi (2015. ) Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.PloS one, , 10 (6 ) ,e0127923 More Information

Akunuru, S; James Zhai, Q; Zheng, Y (2012. ) Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity.Cell death & disease, , 3 ,e352 More Information

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian (2020. ) Role of c-Myc haploinsufficiency in the maintenance of HSCs.Blood, , More Information

Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi (2015. ) Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme.The Journal of biological chemistry, , 290 (20 ) ,12879-98 More Information

Shang, Xun; Marchioni, Fillipo; Sipes, Nisha; Evelyn, Chris R; Jerabek-Willemsen, Moran; Duhr, Stefan; Seibel, William; Wortman, Matthew; Zheng, Yi (2012. ) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.Chemistry & biology, , 19 (6 ) ,699-710 More Information

Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard (2018. ) Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.Cancer cell, , 33 (2 ) ,292-308.e7 More Information

Mikelis, Constantinos M; Simaan, May; Ando, Koji; Fukuhara, Shigetomo; Sakurai, Atsuko; Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto; Chavakis, Triantafyllos; Adams, Ralf H; Offermanns, Stefan; Mochizuki, Naoki; Zheng, Yi; Gutkind, J Silvio (2015. ) RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.Nature communications, , 6 ,6725 More Information

Bosco, E E; Nakai, Y; Hennigan, R F; Ratner, N; Zheng, Y (2010. ) NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation.Oncogene, , 29 (17 ) ,2540-9 More Information

Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi (2017. ) Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.Autophagy, , 13 (5 ) ,955-966 More Information

Li, Juan; Zhang, Lei; Chen, Zhenzhong; Xie, Minjuan; Huang, Lu; Xue, Jinhua; Liu, Yutong; Liu, Nuyun; Guo, Fukun; Zheng, Yi; Kong, Jiming; Zhang, Lin; Zhang, Lu (2015. ) Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen.Neurobiology of disease, , 75 ,159-76 More Information

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Lin, Yuan; Zheng, Yi (2015. ) Approaches of targeting Rho GTPases in cancer drug discovery.Expert opinion on drug discovery, , 10 (9 ) ,991-1010 More Information

Thomas, E K; Cancelas, J A; Zheng, Y; Williams, D A (2008. ) Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.Leukemia, , 22 (5 ) ,898-904 More Information

Zhang, Shuangmin; Konstantinidis, Diamantis G; Yang, Jun-Qi; Mizukawa, Benjamin; Kalim, Khalid; Lang, Richard A; Kalfa, Theodosia A; Zheng, Yi; Guo, Fukun (2014. ) Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development.Journal of immunology (Baltimore, Md. : 1950), , 193 (12 ) ,5973-82 More Information

Geiger, Hartmut; Zheng, Yi (2014. ) Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.Experimental cell research, , 329 (2 ) ,214-9 More Information

Akbar, H; Kim, J; Funk, K; Cancelas, J A; Shang, X; Chen, L; Johnson, J F; Williams, D A; Zheng, Y (2007. ) Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.Journal of thrombosis and haemostasis : JTH, , 5 (8 ) ,1747-55 More Information

Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, A K; Tandon, N N; Bergmeier, W; Zheng, Y (2018. ) Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation.Journal of thrombosis and haemostasis : JTH, , 16 (10 ) ,2083-2096 More Information

Fabbiano, Salvatore; Menacho-Márquez, Mauricio; Sevilla, María A; Albarrán-Juárez, Julián; Zheng, Yi; Offermanns, Stefan; Montero, María J; Bustelo, Xosé R (2014. ) Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells.Molecular and cellular biology, , 34 (24 ) ,4404-19 More Information

Gu, Y; Siefring, J E; Wang, L; Chae, H-D; Bailey, J R; Zheng, Y (2006. ) Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation.Oncogene, , 25 (28 ) ,3963-72 More Information

Nassar, Nicolas; Cancelas, Jose; Zheng, Jie; Williams, David A; Zheng, Yi (2006. ) Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Current topics in medicinal chemistry, , 6 (11 ) ,1109-16

Sakamori, Ryotaro; Yu, Shiyan; Zhang, Xiao; Hoffman, Andrew; Sun, Jiaxin; Das, Soumyashree; Vedula, Pavan; Li, Guangxun; Fu, Jiang; Walker, Francesca; Yang, Chung S; Yi, Zheng; Hsu, Wei; Yu, Da-Hai; Shen, Lanlan; Rodriguez, Alexis J; Taketo, Makoto M; Bonder, Edward M; Verzi, Michael P; Gao, Nan (2014. ) CDC42 inhibition suppresses progression of incipient intestinal tumors.Cancer research, , 74 (19 ) ,5480-92 More Information

Delaney, Michael Keegan; Liu, Junling; Kim, Kyungho; Shen, Bo; Stojanovic-Terpo, Aleksandra; Zheng, Yi; Cho, Jaehyung; Du, Xiaoping (2014. ) Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.Blood, , 124 (12 ) ,1957-67 More Information

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Giger, Katie; Manganaris, Stefanos; Zheng, Yi; Kalfa, Theodosia A (2014. ) Identification of a murine erythroblast subpopulation enriched in enucleating events by multi-spectral imaging flow cytometry.Journal of visualized experiments : JoVE, , (88 ) , More Information

Akbar, Huzoor; Cancelas, Jose; Williams, David A; Zheng, Jie; Zheng, Yi (2006. ) Rational design and applications of a Rac GTPase-specific small molecule inhibitor.Methods in enzymology, , 406 ,554-65 More Information

Kalfa, Theodosia A; Zheng, Yi (2014. ) Rho GTPases in erythroid maturation.Current opinion in hematology, , 21 (3 ) ,165-71 More Information

Zhu, Yajie; Zhou, Jitao; Xia, Hongwei; Chen, Xiangzheng; Qiu, Meng; Huang, Juan; Liu, Surui; Tang, Qiulin; Lang, Nan; Liu, Zhen; Liu, Ming; Zheng, Yi; Bi, Feng (2014. ) The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells.International journal of oncology, , 44 (3 ) ,896-904 More Information

Zheng, Yi; Geiger, Hartmut (2014. ) HSPCs get their motors running for asymmetric fate choice.Cell stem cell, , 14 (1 ) ,1-2 More Information

Zhou, Xuan; Zheng, Yi (2013. ) Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting.The Journal of biological chemistry, , 288 (51 ) ,36179-88 More Information

Melendez, Jaime; Liu, Ming; Sampson, Leesa; Akunuru, Shailaja; Han, Xiaonan; Vallance, Jefferson; Witte, David; Shroyer, Noah; Zheng, Yi (2013. ) Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice.Gastroenterology, , 145 (4 ) ,808-19 More Information

Katayama, Kei-ichi; Imai, Fumiyasu; Campbell, Kenneth; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka (2013. ) RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration.Development (Cambridge, England), , 140 (15 ) ,3139-45 More Information

Kumar, Sachin; Xu, Juying; Perkins, Charles; Guo, Fukun; Snapper, Scott; Finkelman, Fred D; Zheng, Yi; Filippi, Marie-Dominique (2012. ) Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules.Blood, , 120 (17 ) ,3563-74 More Information

Katayama, Kei-ichi; Leslie, Jennifer R; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka (2012. ) Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (30 ) ,10396-407 More Information

Liu, Ming; Bi, Feng; Zhou, Xuan; Zheng, Yi (2012. ) Rho GTPase regulation by miRNAs and covalent modifications.Trends in cell biology, , 22 (7 ) ,365-73 More Information

Leslie, Jennifer R; Imai, Fumiyasu; Zhou, Xuan; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka (2012. ) RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia.Frontiers in molecular neuroscience, , 5 ,67 More Information

Bosco, Emily E; Kumar, Sachin; Marchioni, Filippo; Biesiada, Jacek; Kordos, Miroslaw; Szczur, Kathleen; Meller, Jarek; Seibel, William; Mizrahi, Ariel; Pick, Edgar; Filippi, Marie-Dominique; Zheng, Yi (2012. ) Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.Chemistry & biology, , 19 (2 ) ,228-42 More Information

Shang, Xun; Zheng, Yi (2012. ) Rational design of Rho GTPase-targeting inhibitors.Methods in molecular biology (Clifton, N.J.), , 928 ,29-38 More Information

Plageman, Timothy F; Chauhan, Bharesh K; Yang, Christine; Jaudon, Fanny; Shang, Xun; Zheng, Yi; Lou, Ming; Debant, Anne; Hildebrand, Jeffrey D; Lang, Richard A (2011. ) A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.Development (Cambridge, England), , 138 (23 ) ,5177-88 More Information

Chauhan, Bharesh K; Lou, Ming; Zheng, Yi; Lang, Richard A (2011. ) Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.Proceedings of the National Academy of Sciences of the United States of America, , 108 (45 ) ,18289-94 More Information

Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying (2011. ) Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure.Proceedings of the National Academy of Sciences of the United States of America, , 108 (42 ) ,17349-54 More Information

Stengel, Kristy; Zheng, Yi (2011. ) Cdc42 in oncogenic transformation, invasion, and tumorigenesis.Cellular signalling, , 23 (9 ) ,1415-23 More Information

Wang, Xiaofang; Zhang, Fan; Chen, Fanping; Liu, Dou; Zheng, Yi; Zhang, Yongliang; Dong, Chen; Su, Bing (2011. ) MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.Journal of immunology (Baltimore, Md. : 1950), , 186 (10 ) ,5791-800 More Information

Katayama, Kei-ichi; Melendez, Jaime; Baumann, Jessica M; Leslie, Jennifer R; Chauhan, Bharesh K; Nemkul, Niza; Lang, Richard A; Kuan, Chia-Yi; Zheng, Yi; Yoshida, Yutaka (2011. ) Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.Proceedings of the National Academy of Sciences of the United States of America, , 108 (18 ) ,7607-12 More Information

Melendez, Jaime; Stengel, Kristy; Zhou, Xuan; Chauhan, Bharesh K; Debidda, Marcella; Andreassen, Paul; Lang, Richard A; Zheng, Yi (2011. ) RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts.The Journal of biological chemistry, , 286 (17 ) ,15132-7 More Information

Guo, Fukun; Zhang, Shuangmin; Tripathi, Pulak; Mattner, Jochen; Phelan, James; Sproles, Alyssa; Mo, Jun; Wills-Karp, Marsha; Grimes, H Leighton; Hildeman, David; Zheng, Yi (2011. ) Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.PloS one, , 6 (3 ) ,e18002 More Information

Akunuru, Shailaja; Palumbo, Joseph; Zhai, Qihui James; Zheng, Yi (2011. ) Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.PloS one, , 6 (2 ) ,e16951 More Information

Melendez, Jaime; Grogg, Matthew; Zheng, Yi (2011. ) Signaling role of Cdc42 in regulating mammalian physiology.The Journal of biological chemistry, , 286 (4 ) ,2375-81 More Information

Liu, Wei; Feng, Yuxin; Shang, Xun; Zheng, Yi (2011. ) Rho GTPases in hematopoietic stem/progenitor cell migration.Methods in molecular biology (Clifton, N.J.), , 750 ,307-19 More Information

Guo, Fukun; Hildeman, David; Tripathi, Pulak; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi (2010. ) Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.Proceedings of the National Academy of Sciences of the United States of America, , 107 (43 ) ,18505-10 More Information

George, Alex; Pushkaran, Suvarnamala; Li, Lina; An, Xiuli; Zheng, Yi; Mohandas, Narla; Joiner, Clinton H; Kalfa, Theodosia A (2010. ) Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species.Blood cells, molecules & diseases, , 45 (1 ) ,41-5 More Information

Bosco, Emily E; Ni, Wenjun; Wang, Lei; Guo, Fukun; Johnson, James F; Zheng, Yi (2010. ) Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis.Blood, , 115 (16 ) ,3320-8 More Information

Szczur, Kathleen; Zheng, Yi; Filippi, Marie-Dominique (2009. ) The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling.Blood, , 114 (20 ) ,4527-37 More Information

Chauhan, Bharesh K; Disanza, Andrea; Choi, Sue-Yeon; Faber, Sonya C; Lou, Ming; Beggs, Hilary E; Scita, Giorgio; Zheng, Yi; Lang, Richard A (2009. ) Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.Development (Cambridge, England), , 136 (21 ) ,3657-67 More Information

Xu, Haiming; Eleswarapu, Satyam; Geiger, Hartmut; Szczur, Kathleen; Daria, Deidre; Zheng, Yi; Settleman, Jeffrey; Srour, Edward F; Williams, David A; Filippi, Marie-Dominique (2009. ) Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.Blood, , 114 (17 ) ,3557-66 More Information

Guo, Fukun; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi (2009. ) Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.Blood, , 114 (14 ) ,2909-16 More Information

Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D (2009. ) Cdc42 is an antihypertrophic molecular switch in the mouse heart.The Journal of clinical investigation, , 119 (10 ) ,3079-88 More Information

Marchioni, Filippo; Zheng, Yi (2009. ) Targeting rho GTPases by peptidic structures. Current pharmaceutical design, , 15 (21 ) ,2481-7

Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi (2009. ) Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly.Developmental biology, , 325 (1 ) ,162-70 More Information

Zhang, Xiaoling; Shang, Xun; Guo, Fukun; Murphy, Kim; Kirby, Michelle; Kelly, Patrick; Reeves, Lilith; Smith, Franklin O; Williams, David A; Zheng, Yi; Pang, Qishen (2008. ) Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.Blood, , 112 (5 ) ,1683-6 More Information

Yang, Linda; Zheng, Yi (2007. ) Cdc42: a signal coordinator in hematopoietic stem cell maintenance. Cell cycle (Georgetown, Tex.), , 6 (12 ) ,1445-50

Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi (2007. ) Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 27 (14 ) ,3884-93 More Information

Shang, Xun; Moon, Sun Young; Zheng, Yi (2007. ) p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways.The Journal of biological chemistry, , 282 (12 ) ,8801-11 More Information

Wang, Lei; Zheng, Yi (2007. ) Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.Trends in cell biology, , 17 (2 ) ,58-64 More Information

Guo, Dagang; Tan, Ying-cai; Wang, Dawei; Madhusoodanan, K S; Zheng, Yi; Maack, Thomas; Zhang, J Jillian; Huang, Xin-Yun (2007. ) A Rac-cGMP signaling pathway.Cell, , 128 (2 ) ,341-55 More Information

Wang, Lei; Yang, Linda; Debidda, Marcella; Witte, David; Zheng, Yi (2007. ) Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.Proceedings of the National Academy of Sciences of the United States of America, , 104 (4 ) ,1248-53 More Information

Szczur, Kathleen; Xu, Haiming; Atkinson, Simon; Zheng, Yi; Filippi, Marie-Dominique (2006. ) Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils.Blood, , 108 (13 ) ,4205-13 More Information

Debidda, Marcella; Williams, David A; Zheng, Yi (2006. ) Rac1 GTPase regulates cell genomic stability and senescence.The Journal of biological chemistry, , 281 (50 ) ,38519-28 More Information

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Mohandas, Narla; Hartwig, John H; Fowler, Velia M; Johnson, James F; Joiner, Clinton H; Williams, David A; Zheng, Yi (2006. ) Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.Blood, , 108 (12 ) ,3637-45 More Information

Yang, Linda; Wang, Lei; Zheng, Yi (2006. ) Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts.Molecular biology of the cell, , 17 (11 ) ,4675-85 More Information

Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi (2006. ) Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.Proceedings of the National Academy of Sciences of the United States of America, , 103 (44 ) ,16520-5 More Information

Xing, Zhenlan; Ryan, Marnie A; Daria, Deidre; Nattamai, Kalpana J; Van Zant, Gary; Wang, Lei; Zheng, Yi; Geiger, Hartmut (2006. ) Increased hematopoietic stem cell mobilization in aged mice.Blood, , 108 (7 ) ,2190-7 More Information

Guo, Fukun; Debidda, Marcella; Yang, Linda; Williams, David A; Zheng, Yi (2006. ) Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.The Journal of biological chemistry, , 281 (27 ) ,18652-9 More Information

Wang, Lei; Yang, Linda; Filippi, Marie-Dominique; Williams, David A; Zheng, Yi (2006. ) Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.Blood, , 107 (1 ) ,98-105 More Information

Wang, Lei; Yang, Linda; Burns, Kevin; Kuan, Chia-Yi; Zheng, Yi (2005. ) Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth.Proceedings of the National Academy of Sciences of the United States of America, , 102 (38 ) ,13484-9 More Information

Debidda, Marcella; Wang, Lei; Zang, Heesuk; Poli, Valeria; Zheng, Yi (2005. ) A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.The Journal of biological chemistry, , 280 (17 ) ,17275-85 More Information

Carstanjen, Dirk; Yamauchi, Akira; Koornneef, Annemart; Zang, Heesuk; Filippi, Marie-Dominique; Harris, Chad; Towe, Jason; Atkinson, Simon; Zheng, Yi; Dinauer, Mary C; Williams, David A (2005. ) Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of immunology (Baltimore, Md. : 1950), , 174 (8 ) ,4613-20

Gu, Yi; Zheng, Yi; Williams, David A (2005. ) RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis?.Cell cycle (Georgetown, Tex.), , 4 (2 ) ,201-2 More Information

Wang, Lei; Zhu, Kejin; Zheng, Yi (2004. ) Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains.Biochemistry, , 43 (46 ) ,14584-93 More Information

Guo, Fukun; Zheng, Yi (2004. ) Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion.Oncogene, , 23 (33 ) ,5577-85 More Information

Gao, Yuan; Dickerson, J Bradley; Guo, Fukun; Zheng, Jie; Zheng, Yi (2004. ) Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.Proceedings of the National Academy of Sciences of the United States of America, , 101 (20 ) ,7618-23 More Information

Cook-Mills, Joan M; Johnson, Jacob D; Deem, Tracy L; Ochi, Atsuo; Wang, Lei; Zheng, Yi (2004. ) Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity.The Biochemical journal, , 378 (Pt 2 ) ,539-47 More Information

Guo, Fukun; Zheng, Yi (2004. ) Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts. Molecular and cellular biology, , 24 (3 ) ,1426-38

Debreceni, Balazs; Gao, Yuan; Guo, Fukun; Zhu, Kejin; Jia, Baoqing; Zheng, Yi (2004. ) Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.The Journal of biological chemistry, , 279 (5 ) ,3777-86 More Information

Wang, Lei; Yang, Linda; Luo, Yongneng; Zheng, Yi (2003. ) A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.The Journal of biological chemistry, , 278 (45 ) ,44617-25 More Information

Zheng, Yi; Quilliam, Lawrence A (2003. ) Activation of the Ras superfamily of small GTPases. Workshop on exchange factors.EMBO reports, , 4 (5 ) ,463-8 More Information

Guo, Fukun; Gao, Yuan; Wang, Lei; Zheng, Yi (2003. ) p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities.The Journal of biological chemistry, , 278 (16 ) ,14414-9 More Information

Moon, Sun Young; Zang, Heesuk; Zheng, Yi (2003. ) Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP.The Journal of biological chemistry, , 278 (6 ) ,4151-9 More Information

Moon, Sun Young; Zheng, Yi (2003. ) Rho GTPase-activating proteins in cell regulation. Trends in cell biology, , 13 (1 ) ,13-22

Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L (2018. ) Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma.Oncotarget, , 9 (37 ) ,24750-24765 More Information

Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D (2018. ) Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart.Circulation, , More Information

Contact Information

Academic - Cincinnati Children's Hospital
Phone: 513-636-0595
Yi.Zheng@cchmc.org