Yi Zheng

Yi Zheng

Co-Director, Cincinnati Children's Cancer and Blood Diseases Institute
Professor, Department of Pediatrics, UC College of Medicine
Director, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center,
Affiliate Faculty Cancer Biology

Childrens Hospital Bldg R

7501

COM Pediatrics Experimental Hematology - 0054

Cincinnati Children's Hospital

Publications

Peer Reviewed Publications

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi (2010. ) Rho GTPases in hematopoiesis and hemopathies.Blood, , 115 (5 ) ,936-47

Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy (2006. ) Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 26 (13 ) ,3390-5

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A (2007. ) Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.Cancer cell, , 12 (5 ) ,467-78

Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi (2014. ) Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.Chemistry & biology, , 21 (12 ) ,1618-28

Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy (2012. ) Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (48 ) ,17251-61

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A (2012. ) Signaling and cytoskeletal requirements in erythroblast enucleation.Blood, , 119 (25 ) ,6118-27

Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun (2012. ) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.Molecular pharmacology, , 81 (6 ) ,811-9

Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C (2011. ) Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.Blood, , 118 (19 ) ,5235-45

Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi (2011. ) Cdc42 regulates extracellular matrix remodeling in three dimensions.The Journal of biological chemistry, , 286 (42 ) ,36469-77

Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I (2011. ) Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility.Journal of virology, , 85 (20 ) ,10487-98

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun (2019. ) Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , 49 (1 ) ,92-107

Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi (2011. ) R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.The Journal of biological chemistry, , 286 (27 ) ,24068-78

Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina (2018. ) LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.Genome biology, , 19 (1 ) ,189

Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut (2010. ) Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.Nature medicine, , 16 (10 ) ,1141-6

Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang (2018. ) Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.Cancer discovery, , 8 (11 ) ,1438-1457

Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A (2018. ) Towards increasing shelf life and haemostatic potency of stored platelet concentrates.Current opinion in hematology, , 25 (6 ) ,500-508

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi (2010. ) Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.Haematologica, , 95 (1 ) ,27-35

Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi (2018. ) Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.Leukemia, ,

Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A (2009. ) Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766.Haematologica, , 94 (7 ) ,1011-5

Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut (2018. ) Aging alters the epigenetic asymmetry of HSC division.PLoS biology, , 16 (9 ) ,e2003389

Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping (2008. ) Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling.Cell cycle (Georgetown, Tex.), , 7 (21 ) ,3314-9

Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi (2018. ) A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells.Leukemia, , 32 (9 ) ,2041-2046

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C (2008. ) Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Cancer cell, , 13 (6 ) ,483-95

Cai, Xiongwei; Zheng, Yi; Speck, Nancy A (2018. ) A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells.Journal of visualized experiments : JoVE, , (138 ) ,

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2018. ) Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 9 (1 ) ,670

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T (2018. ) TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis.Cell reports, , 22 (5 ) ,1250-1262

Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi (2007. ) Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.Proceedings of the National Academy of Sciences of the United States of America, , 104 (12 ) ,5091-6

Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi (2018. ) Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.Methods in molecular biology (Clifton, N.J.), , 1821 ,257-266

Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A (2006. ) Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.Blood, , 108 (6 ) ,2087-94

Cai, Xiongwei; Zhou, Xuan; Zheng, Yi (2018. ) In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells.Methods in molecular biology (Clifton, N.J.), , 1821 ,247-256

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2017. ) Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 8 (1 ) ,2099

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut (2017. ) Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.Cell reports, , 18 (11 ) ,2608-2621

Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A (2005. ) Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.Nature medicine, , 11 (8 ) ,886-91

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T (2017. ) Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.Nature immunology, , 18 (2 ) ,236-245

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying (2005. ) MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.Molecular and cellular biology, , 25 (1 ) ,60-5

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A (2015. ) Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation.Nature communications, , 6 ,5914

Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun (2018. ) Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.Journal of immunology (Baltimore, Md. : 1950), , 200 (7 ) ,2313-2326

Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy (2013. ) Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling.Glia, , 61 (11 ) ,1906-21

Yang, Yingying; Dong, Panpan; Zhao, Jing; Zhou, Wei; Zhou, Yonghua; Xu, Yongliang; Mei, Congjin; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi (2018. ) PKC?/? regulates Th17 differentiation and house dust mite-induced allergic airway inflammation.Biochimica et biophysica acta, , 1864 (3 ) ,934-941

Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong (2018. ) Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.Respiratory research, , 19 (1 ) ,27

Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi (2013. ) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.Proceedings of the National Academy of Sciences of the United States of America, , 110 (8 ) ,3155-60

Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi (2017. ) RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance.Stem cell reports, , 9 (6 ) ,1961-1975

Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A (2012. ) Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.Blood, , 120 (4 ) ,800-11

Guo, Fukun; Zheng, Yi (2017. ) Vav1: Friend and Foe of Cancer.Trends in cell biology, , 27 (12 ) ,879-880

Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei (2017. ) YAP/TAZ-CDC42 signaling regulates vascular tip cell migration.Proceedings of the National Academy of Sciences of the United States of America, , 114 (41 ) ,10918-10923

Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C; Wunderlich, Mark; Hochstetler, Cindy L; Duan, Xin; Liu, Wei; Orr, Emily; Grimes, H Leighton; Mulloy, James C; Zheng, Yi (2017. ) The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.Blood, , 130 (11 ) ,1336-1346

Williams, David A; Zheng, Yi; Cancelas, Jose A (2008. ) Rho GTPases and regulation of hematopoietic stem cell localization.Methods in enzymology, , 439 ,365-93

Kalim, Khalid W; Zhang, Shuangmin; Chen, Xiaoyi; Li, Yuan; Yang, Jun-Qi; Zheng, Yi; Guo, Fukun (2017. ) mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.PloS one, , 12 (8 ) ,e0183266

Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi (2007. ) Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.Blood, , 110 (12 ) ,3853-61

Hato, Takashi; Winfree, Seth; Day, Richard; Sandoval, Ruben M; Molitoris, Bruce A; Yoder, Mervin C; Wiggins, Roger C; Zheng, Yi; Dunn, Kenneth W; Dagher, Pierre C (2017. ) Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures.Journal of the American Society of Nephrology : JASN, , 28 (8 ) ,2420-2430

Sinagoga, Katie L; Stone, William J; Schiesser, Jacqueline V; Schweitzer, Jamie I; Sampson, Leesa; Zheng, Yi; Wells, James M (2017. ) Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.Development (Cambridge, England), , 144 (13 ) ,2402-2414

Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M (2019. ) Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.Scientific reports, , 9 (1 ) ,11666

El Zowalaty, Ahmed E; Li, Rong; Zheng, Yi; Lydon, John P; DeMayo, Francesco J; Ye, Xiaoqin (2017. ) Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice.Endocrinology, , 158 (7 ) ,2168-2178

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi (2010. ) Rho GTPases in hematopoiesis and hemopathies.Blood, , 115 (5 ) ,936-47

Qiu, Sugan; Fan, Xiaolin; Yang, Yingying; Dong, Panpan; Zhou, Wei; Xu, Yongliang; Zhou, Yonghua; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi (2017. ) Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice.PloS one, , 12 (6 ) ,e0179565

Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying (2019. ) Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.Haematologica, ,

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun (2019. ) Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation.Journal of leukocyte biology, ,

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A (2007. ) Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.Cancer cell, , 12 (5 ) ,467-78

Li, Jingjing; Miao, Lianjie; Zhao, Chen; Shaikh Qureshi, Wasay Mohiuddin; Shieh, David; Guo, Hua; Lu, Yangyang; Hu, Saiyang; Huang, Alice; Zhang, Lu; Cai, Chen-Leng; Wan, Leo Q; Xin, Hongbo; Vincent, Peter; Singer, Harold A; Zheng, Yi; Cleaver, Ondine; Fan, Zhen-Chuan; Wu, Mingfu (2017. ) CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane.Development (Cambridge, England), , 144 (9 ) ,1635-1647

Filippi, Marie-Dominique; Harris, Chad E; Meller, Jarek; Gu, Yi; Zheng, Yi; Williams, David A (2004. ) Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.Nature immunology, , 5 (7 ) ,744-51

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A (2019. ) The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors.Nature communications, , 10 (1 ) ,46

Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy (2006. ) Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 26 (13 ) ,3390-5

Akbar, Huzoor; Duan, Xin; Saleem, Saima; Davis, Ashley K; Zheng, Yi RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets.PloS one, , 11 (9 ) ,e0163227

Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong (2019. ) ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.Haematologica, ,

Barry, David M; Koo, Yeon; Norden, Pieter R; Wylie, Lyndsay A; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D Berfin; Zheng, Yi; Cobb, Melanie H; Davis, George E; Cleaver, Ondine (2016. ) Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II.Circulation research, , 119 (7 ) ,810-26

Zandvakili, I; Lin, Y; Morris, J C; Zheng, Y (2017. ) Rho GTPases: Anti- or pro-neoplastic targets?.Oncogene, , 36 (23 ) ,3213-3222

Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi (2019. ) KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals.Experimental hematology, ,

Imai, Fumiyasu; Ladle, David R; Leslie, Jennifer R; Duan, Xin; Rizvi, Tilat A; Ciraolo, Georgianne M; Zheng, Yi; Yoshida, Yutaka (2016. ) Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 36 (21 ) ,5724-35

Palazzo, A; Bluteau, O; Messaoudi, K; Marangoni, F; Chang, Y; Souquere, S; Pierron, G; Lapierre, V; Zheng, Y; Vainchenker, W; Raslova, H; Debili, N (2016. ) The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.Journal of thrombosis and haemostasis : JTH, , 14 (12 ) ,2524-2535

Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi (2019. ) Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection.Cells, , 8 (10 ) ,

Nohata, Nijiro; Uchida, Yutaka; Stratman, Amber N; Adams, Ralf H; Zheng, Yi; Weinstein, Brant M; Mukouyama, Yoh-Suke; Gutkind, J Silvio (2016. ) Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.Developmental biology, , 411 (2 ) ,183-194

O'Hayre, M; Inoue, A; Kufareva, I; Wang, Z; Mikelis, C M; Drummond, R A; Avino, S; Finkel, K; Kalim, K W; DiPasquale, G; Guo, F; Aoki, J; Zheng, Y; Lionakis, M S; Molinolo, A A; Gutkind, J S (2016. ) Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G?13/RhoA axis in B cells.Oncogene, , 35 (29 ) ,3771-80

Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun (2019. ) Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma.Frontiers in oncology, , 9 ,958

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T (2020. ) Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.Nature immunology, , 21 (5 ) ,535-545

Sampson, Leesa L; Davis, Ashley K; Grogg, Matthew W; Zheng, Yi (2016. ) mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 30 (3 ) ,1263-75

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad (2015. ) Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.Scientific reports, , 5 ,14538

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Althoff, Mark; Nayak, Ramesh; Hegde, Shailaja; Wellendorf, Ashley; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A (2020. ) Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.Blood, ,

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zhang, Shuangmin; Hinge, Ashwini; Filippi, Marie-Dominique; Zheng, Yi; Guo, Fukun (2016. ) RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation.The Journal of allergy and clinical immunology, , 137 (1 ) ,231-245.e4

Guo, F; Li, J; Zhang, S; Du, W; Amarachintha, S; Sipple, J; Phelan, J; Grimes, H L; Zheng, Y; Pang, Q (2014. ) mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression.Leukemia, , 28 (1 ) ,203-6

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I (2018. ) Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy.International journal of particle therapy, , 5 (1 ) ,40-48

Florian, Maria Carolina; Leins, Hanna; Gobs, Michael; Han, Yang; Marka, Gina; Soller, Karin; Vollmer, Angelika; Sakk, Vadim; Nattamai, Kalpana J; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Mulaw, Medhanie; Wagner, Wolfgang; Zheng, Yi; Geiger, Hartmut (2020. ) Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice.Aging cell, , e13208

Konstantinidis, Diamantis G; Giger, Katie M; Risinger, Mary; Pushkaran, Suvarnamala; Zhou, Ping; Dexheimer, Phillip; Yerneni, Satwica; Andreassen, Paul; Klingmüller, Ursula; Palis, James; Zheng, Yi; Kalfa, Theodosia A (2015. ) Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation.Blood, , 126 (12 ) ,1473-82

Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi (2013. ) RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors.The Journal of experimental medicine, , 210 (11 ) ,2371-85

Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro (2020. ) Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.Nature communications, , 11 (1 ) ,3878

Barry, David M; Xu, Ke; Meadows, Stryder M; Zheng, Yi; Norden, Pieter R; Davis, George E; Cleaver, Ondine (2015. ) Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice.Development (Cambridge, England), , 142 (17 ) ,3058-70

Guo, F; Li, J; Du, W; Zhang, S; O'Connor, M; Thomas, G; Kozma, S; Zingarelli, B; Pang, Q; Zheng, Y (2013. ) mTOR regulates DNA damage response through NF-?B-mediated FANCD2 pathway in hematopoietic cells.Leukemia, , 27 (10 ) ,2040-2046

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian (2020. ) Role of c-Myc haploinsufficiency in the maintenance of HSCs.Blood, ,

Zandvakili, Inuk; Davis, Ashley Kuenzi; Hu, Guodong; Zheng, Yi (2015. ) Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.PloS one, , 10 (6 ) ,e0127923

Akunuru, S; James Zhai, Q; Zheng, Y (2012. ) Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity.Cell death & disease, , 3 ,e352

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian (2020. ) Role of c-Myc haploinsufficiency in the maintenance of HSCs.Blood, ,

Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi (2015. ) Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme.The Journal of biological chemistry, , 290 (20 ) ,12879-98

Shang, Xun; Marchioni, Fillipo; Sipes, Nisha; Evelyn, Chris R; Jerabek-Willemsen, Moran; Duhr, Stefan; Seibel, William; Wortman, Matthew; Zheng, Yi (2012. ) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.Chemistry & biology, , 19 (6 ) ,699-710

Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard (2018. ) Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.Cancer cell, , 33 (2 ) ,292-308.e7

Mikelis, Constantinos M; Simaan, May; Ando, Koji; Fukuhara, Shigetomo; Sakurai, Atsuko; Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto; Chavakis, Triantafyllos; Adams, Ralf H; Offermanns, Stefan; Mochizuki, Naoki; Zheng, Yi; Gutkind, J Silvio (2015. ) RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.Nature communications, , 6 ,6725

Bosco, E E; Nakai, Y; Hennigan, R F; Ratner, N; Zheng, Y (2010. ) NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation.Oncogene, , 29 (17 ) ,2540-9

Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi (2017. ) Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.Autophagy, , 13 (5 ) ,955-966

Li, Juan; Zhang, Lei; Chen, Zhenzhong; Xie, Minjuan; Huang, Lu; Xue, Jinhua; Liu, Yutong; Liu, Nuyun; Guo, Fukun; Zheng, Yi; Kong, Jiming; Zhang, Lin; Zhang, Lu (2015. ) Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen.Neurobiology of disease, , 75 ,159-76

Bosco, E E; Mulloy, J C; Zheng, Y (2009. ) Rac1 GTPase: a "Rac" of all trades.Cellular and molecular life sciences : CMLS, , 66 (3 ) ,370-4

Lin, Yuan; Zheng, Yi (2015. ) Approaches of targeting Rho GTPases in cancer drug discovery.Expert opinion on drug discovery, , 10 (9 ) ,991-1010

Thomas, E K; Cancelas, J A; Zheng, Y; Williams, D A (2008. ) Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.Leukemia, , 22 (5 ) ,898-904

Zhang, Shuangmin; Konstantinidis, Diamantis G; Yang, Jun-Qi; Mizukawa, Benjamin; Kalim, Khalid; Lang, Richard A; Kalfa, Theodosia A; Zheng, Yi; Guo, Fukun (2014. ) Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development.Journal of immunology (Baltimore, Md. : 1950), , 193 (12 ) ,5973-82

Geiger, Hartmut; Zheng, Yi (2014. ) Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.Experimental cell research, , 329 (2 ) ,214-9

Akbar, H; Kim, J; Funk, K; Cancelas, J A; Shang, X; Chen, L; Johnson, J F; Williams, D A; Zheng, Y (2007. ) Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.Journal of thrombosis and haemostasis : JTH, , 5 (8 ) ,1747-55

Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, A K; Tandon, N N; Bergmeier, W; Zheng, Y (2018. ) Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation.Journal of thrombosis and haemostasis : JTH, , 16 (10 ) ,2083-2096

Fabbiano, Salvatore; Menacho-Márquez, Mauricio; Sevilla, María A; Albarrán-Juárez, Julián; Zheng, Yi; Offermanns, Stefan; Montero, María J; Bustelo, Xosé R (2014. ) Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells.Molecular and cellular biology, , 34 (24 ) ,4404-19

Gu, Y; Siefring, J E; Wang, L; Chae, H-D; Bailey, J R; Zheng, Y (2006. ) Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation.Oncogene, , 25 (28 ) ,3963-72

Nassar, Nicolas; Cancelas, Jose; Zheng, Jie; Williams, David A; Zheng, Yi (2006. ) Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Current topics in medicinal chemistry, , 6 (11 ) ,1109-16

Sakamori, Ryotaro; Yu, Shiyan; Zhang, Xiao; Hoffman, Andrew; Sun, Jiaxin; Das, Soumyashree; Vedula, Pavan; Li, Guangxun; Fu, Jiang; Walker, Francesca; Yang, Chung S; Yi, Zheng; Hsu, Wei; Yu, Da-Hai; Shen, Lanlan; Rodriguez, Alexis J; Taketo, Makoto M; Bonder, Edward M; Verzi, Michael P; Gao, Nan (2014. ) CDC42 inhibition suppresses progression of incipient intestinal tumors.Cancer research, , 74 (19 ) ,5480-92

Delaney, Michael Keegan; Liu, Junling; Kim, Kyungho; Shen, Bo; Stojanovic-Terpo, Aleksandra; Zheng, Yi; Cho, Jaehyung; Du, Xiaoping (2014. ) Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.Blood, , 124 (12 ) ,1957-67

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Giger, Katie; Manganaris, Stefanos; Zheng, Yi; Kalfa, Theodosia A (2014. ) Identification of a murine erythroblast subpopulation enriched in enucleating events by multi-spectral imaging flow cytometry.Journal of visualized experiments : JoVE, , (88 ) ,

Akbar, Huzoor; Cancelas, Jose; Williams, David A; Zheng, Jie; Zheng, Yi (2006. ) Rational design and applications of a Rac GTPase-specific small molecule inhibitor.Methods in enzymology, , 406 ,554-65

Kalfa, Theodosia A; Zheng, Yi (2014. ) Rho GTPases in erythroid maturation.Current opinion in hematology, , 21 (3 ) ,165-71

Zhu, Yajie; Zhou, Jitao; Xia, Hongwei; Chen, Xiangzheng; Qiu, Meng; Huang, Juan; Liu, Surui; Tang, Qiulin; Lang, Nan; Liu, Zhen; Liu, Ming; Zheng, Yi; Bi, Feng (2014. ) The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells.International journal of oncology, , 44 (3 ) ,896-904

Zheng, Yi; Geiger, Hartmut (2014. ) HSPCs get their motors running for asymmetric fate choice.Cell stem cell, , 14 (1 ) ,1-2

Zhou, Xuan; Zheng, Yi (2013. ) Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting.The Journal of biological chemistry, , 288 (51 ) ,36179-88

Melendez, Jaime; Liu, Ming; Sampson, Leesa; Akunuru, Shailaja; Han, Xiaonan; Vallance, Jefferson; Witte, David; Shroyer, Noah; Zheng, Yi (2013. ) Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice.Gastroenterology, , 145 (4 ) ,808-19

Katayama, Kei-ichi; Imai, Fumiyasu; Campbell, Kenneth; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka (2013. ) RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration.Development (Cambridge, England), , 140 (15 ) ,3139-45

Kumar, Sachin; Xu, Juying; Perkins, Charles; Guo, Fukun; Snapper, Scott; Finkelman, Fred D; Zheng, Yi; Filippi, Marie-Dominique (2012. ) Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules.Blood, , 120 (17 ) ,3563-74

Katayama, Kei-ichi; Leslie, Jennifer R; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka (2012. ) Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (30 ) ,10396-407

Liu, Ming; Bi, Feng; Zhou, Xuan; Zheng, Yi (2012. ) Rho GTPase regulation by miRNAs and covalent modifications.Trends in cell biology, , 22 (7 ) ,365-73

Leslie, Jennifer R; Imai, Fumiyasu; Zhou, Xuan; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka (2012. ) RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia.Frontiers in molecular neuroscience, , 5 ,67

Bosco, Emily E; Kumar, Sachin; Marchioni, Filippo; Biesiada, Jacek; Kordos, Miroslaw; Szczur, Kathleen; Meller, Jarek; Seibel, William; Mizrahi, Ariel; Pick, Edgar; Filippi, Marie-Dominique; Zheng, Yi (2012. ) Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.Chemistry & biology, , 19 (2 ) ,228-42

Shang, Xun; Zheng, Yi (2012. ) Rational design of Rho GTPase-targeting inhibitors.Methods in molecular biology (Clifton, N.J.), , 928 ,29-38

Plageman, Timothy F; Chauhan, Bharesh K; Yang, Christine; Jaudon, Fanny; Shang, Xun; Zheng, Yi; Lou, Ming; Debant, Anne; Hildebrand, Jeffrey D; Lang, Richard A (2011. ) A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.Development (Cambridge, England), , 138 (23 ) ,5177-88

Chauhan, Bharesh K; Lou, Ming; Zheng, Yi; Lang, Richard A (2011. ) Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.Proceedings of the National Academy of Sciences of the United States of America, , 108 (45 ) ,18289-94

Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying (2011. ) Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure.Proceedings of the National Academy of Sciences of the United States of America, , 108 (42 ) ,17349-54

Stengel, Kristy; Zheng, Yi (2011. ) Cdc42 in oncogenic transformation, invasion, and tumorigenesis.Cellular signalling, , 23 (9 ) ,1415-23

Wang, Xiaofang; Zhang, Fan; Chen, Fanping; Liu, Dou; Zheng, Yi; Zhang, Yongliang; Dong, Chen; Su, Bing (2011. ) MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.Journal of immunology (Baltimore, Md. : 1950), , 186 (10 ) ,5791-800

Katayama, Kei-ichi; Melendez, Jaime; Baumann, Jessica M; Leslie, Jennifer R; Chauhan, Bharesh K; Nemkul, Niza; Lang, Richard A; Kuan, Chia-Yi; Zheng, Yi; Yoshida, Yutaka (2011. ) Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.Proceedings of the National Academy of Sciences of the United States of America, , 108 (18 ) ,7607-12

Melendez, Jaime; Stengel, Kristy; Zhou, Xuan; Chauhan, Bharesh K; Debidda, Marcella; Andreassen, Paul; Lang, Richard A; Zheng, Yi (2011. ) RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts.The Journal of biological chemistry, , 286 (17 ) ,15132-7

Guo, Fukun; Zhang, Shuangmin; Tripathi, Pulak; Mattner, Jochen; Phelan, James; Sproles, Alyssa; Mo, Jun; Wills-Karp, Marsha; Grimes, H Leighton; Hildeman, David; Zheng, Yi (2011. ) Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.PloS one, , 6 (3 ) ,e18002

Akunuru, Shailaja; Palumbo, Joseph; Zhai, Qihui James; Zheng, Yi (2011. ) Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.PloS one, , 6 (2 ) ,e16951

Melendez, Jaime; Grogg, Matthew; Zheng, Yi (2011. ) Signaling role of Cdc42 in regulating mammalian physiology.The Journal of biological chemistry, , 286 (4 ) ,2375-81

Liu, Wei; Feng, Yuxin; Shang, Xun; Zheng, Yi (2011. ) Rho GTPases in hematopoietic stem/progenitor cell migration.Methods in molecular biology (Clifton, N.J.), , 750 ,307-19

Guo, Fukun; Hildeman, David; Tripathi, Pulak; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi (2010. ) Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.Proceedings of the National Academy of Sciences of the United States of America, , 107 (43 ) ,18505-10

George, Alex; Pushkaran, Suvarnamala; Li, Lina; An, Xiuli; Zheng, Yi; Mohandas, Narla; Joiner, Clinton H; Kalfa, Theodosia A (2010. ) Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species.Blood cells, molecules & diseases, , 45 (1 ) ,41-5

Bosco, Emily E; Ni, Wenjun; Wang, Lei; Guo, Fukun; Johnson, James F; Zheng, Yi (2010. ) Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis.Blood, , 115 (16 ) ,3320-8

Szczur, Kathleen; Zheng, Yi; Filippi, Marie-Dominique (2009. ) The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling.Blood, , 114 (20 ) ,4527-37

Chauhan, Bharesh K; Disanza, Andrea; Choi, Sue-Yeon; Faber, Sonya C; Lou, Ming; Beggs, Hilary E; Scita, Giorgio; Zheng, Yi; Lang, Richard A (2009. ) Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.Development (Cambridge, England), , 136 (21 ) ,3657-67

Xu, Haiming; Eleswarapu, Satyam; Geiger, Hartmut; Szczur, Kathleen; Daria, Deidre; Zheng, Yi; Settleman, Jeffrey; Srour, Edward F; Williams, David A; Filippi, Marie-Dominique (2009. ) Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.Blood, , 114 (17 ) ,3557-66

Guo, Fukun; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi (2009. ) Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.Blood, , 114 (14 ) ,2909-16

Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D (2009. ) Cdc42 is an antihypertrophic molecular switch in the mouse heart.The Journal of clinical investigation, , 119 (10 ) ,3079-88

Marchioni, Filippo; Zheng, Yi (2009. ) Targeting rho GTPases by peptidic structures. Current pharmaceutical design, , 15 (21 ) ,2481-7

Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi (2009. ) Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly.Developmental biology, , 325 (1 ) ,162-70

Zhang, Xiaoling; Shang, Xun; Guo, Fukun; Murphy, Kim; Kirby, Michelle; Kelly, Patrick; Reeves, Lilith; Smith, Franklin O; Williams, David A; Zheng, Yi; Pang, Qishen (2008. ) Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.Blood, , 112 (5 ) ,1683-6

Yang, Linda; Zheng, Yi (2007. ) Cdc42: a signal coordinator in hematopoietic stem cell maintenance. Cell cycle (Georgetown, Tex.), , 6 (12 ) ,1445-50

Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi (2007. ) Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 27 (14 ) ,3884-93

Shang, Xun; Moon, Sun Young; Zheng, Yi (2007. ) p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways.The Journal of biological chemistry, , 282 (12 ) ,8801-11

Wang, Lei; Zheng, Yi (2007. ) Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.Trends in cell biology, , 17 (2 ) ,58-64

Guo, Dagang; Tan, Ying-cai; Wang, Dawei; Madhusoodanan, K S; Zheng, Yi; Maack, Thomas; Zhang, J Jillian; Huang, Xin-Yun (2007. ) A Rac-cGMP signaling pathway.Cell, , 128 (2 ) ,341-55

Wang, Lei; Yang, Linda; Debidda, Marcella; Witte, David; Zheng, Yi (2007. ) Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.Proceedings of the National Academy of Sciences of the United States of America, , 104 (4 ) ,1248-53

Szczur, Kathleen; Xu, Haiming; Atkinson, Simon; Zheng, Yi; Filippi, Marie-Dominique (2006. ) Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils.Blood, , 108 (13 ) ,4205-13

Debidda, Marcella; Williams, David A; Zheng, Yi (2006. ) Rac1 GTPase regulates cell genomic stability and senescence.The Journal of biological chemistry, , 281 (50 ) ,38519-28

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Mohandas, Narla; Hartwig, John H; Fowler, Velia M; Johnson, James F; Joiner, Clinton H; Williams, David A; Zheng, Yi (2006. ) Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.Blood, , 108 (12 ) ,3637-45

Yang, Linda; Wang, Lei; Zheng, Yi (2006. ) Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts.Molecular biology of the cell, , 17 (11 ) ,4675-85

Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi (2006. ) Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.Proceedings of the National Academy of Sciences of the United States of America, , 103 (44 ) ,16520-5

Xing, Zhenlan; Ryan, Marnie A; Daria, Deidre; Nattamai, Kalpana J; Van Zant, Gary; Wang, Lei; Zheng, Yi; Geiger, Hartmut (2006. ) Increased hematopoietic stem cell mobilization in aged mice.Blood, , 108 (7 ) ,2190-7

Guo, Fukun; Debidda, Marcella; Yang, Linda; Williams, David A; Zheng, Yi (2006. ) Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.The Journal of biological chemistry, , 281 (27 ) ,18652-9

Wang, Lei; Yang, Linda; Filippi, Marie-Dominique; Williams, David A; Zheng, Yi (2006. ) Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.Blood, , 107 (1 ) ,98-105

Wang, Lei; Yang, Linda; Burns, Kevin; Kuan, Chia-Yi; Zheng, Yi (2005. ) Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth.Proceedings of the National Academy of Sciences of the United States of America, , 102 (38 ) ,13484-9

Debidda, Marcella; Wang, Lei; Zang, Heesuk; Poli, Valeria; Zheng, Yi (2005. ) A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.The Journal of biological chemistry, , 280 (17 ) ,17275-85

Carstanjen, Dirk; Yamauchi, Akira; Koornneef, Annemart; Zang, Heesuk; Filippi, Marie-Dominique; Harris, Chad; Towe, Jason; Atkinson, Simon; Zheng, Yi; Dinauer, Mary C; Williams, David A (2005. ) Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of immunology (Baltimore, Md. : 1950), , 174 (8 ) ,4613-20

Gu, Yi; Zheng, Yi; Williams, David A (2005. ) RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis?.Cell cycle (Georgetown, Tex.), , 4 (2 ) ,201-2

Wang, Lei; Zhu, Kejin; Zheng, Yi (2004. ) Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains.Biochemistry, , 43 (46 ) ,14584-93

Guo, Fukun; Zheng, Yi (2004. ) Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion.Oncogene, , 23 (33 ) ,5577-85

Gao, Yuan; Dickerson, J Bradley; Guo, Fukun; Zheng, Jie; Zheng, Yi (2004. ) Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.Proceedings of the National Academy of Sciences of the United States of America, , 101 (20 ) ,7618-23

Cook-Mills, Joan M; Johnson, Jacob D; Deem, Tracy L; Ochi, Atsuo; Wang, Lei; Zheng, Yi (2004. ) Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity.The Biochemical journal, , 378 (Pt 2 ) ,539-47

Guo, Fukun; Zheng, Yi (2004. ) Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts. Molecular and cellular biology, , 24 (3 ) ,1426-38

Debreceni, Balazs; Gao, Yuan; Guo, Fukun; Zhu, Kejin; Jia, Baoqing; Zheng, Yi (2004. ) Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.The Journal of biological chemistry, , 279 (5 ) ,3777-86

Wang, Lei; Yang, Linda; Luo, Yongneng; Zheng, Yi (2003. ) A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.The Journal of biological chemistry, , 278 (45 ) ,44617-25

Zheng, Yi; Quilliam, Lawrence A (2003. ) Activation of the Ras superfamily of small GTPases. Workshop on exchange factors.EMBO reports, , 4 (5 ) ,463-8

Guo, Fukun; Gao, Yuan; Wang, Lei; Zheng, Yi (2003. ) p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities.The Journal of biological chemistry, , 278 (16 ) ,14414-9

Moon, Sun Young; Zang, Heesuk; Zheng, Yi (2003. ) Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP.The Journal of biological chemistry, , 278 (6 ) ,4151-9

Moon, Sun Young; Zheng, Yi (2003. ) Rho GTPase-activating proteins in cell regulation. Trends in cell biology, , 13 (1 ) ,13-22

Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L (2018. ) Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma.Oncotarget, , 9 (37 ) ,24750-24765

Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D (2018. ) Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart.Circulation, ,

Contact Information

Academic - Cincinnati Children's Hospital
Phone: 513-636-0595
Yi.Zheng@cchmc.org