Yi Zheng, PhD

Peer Reviewed Publications

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi  (2010). Rho GTPases in hematopoiesis and hemopathies. Blood, 115 (5) , 936-47More Information

Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy  (2006). Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 (13) , 3390-5More Information

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A  (2007). Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 (5) , 467-78More Information

Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi  (2014). Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chemistry & biology, 21 (12) , 1618-28More Information

Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy  (2012). Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 (48) , 17251-61More Information

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A  (2012). Signaling and cytoskeletal requirements in erythroblast enucleation. Blood, 119 (25) , 6118-27More Information

Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun  (2012). Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Molecular pharmacology, 81 (6) , 811-9More Information

Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C  (2011). Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood, 118 (19) , 5235-45More Information

Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi  (2011). Cdc42 regulates extracellular matrix remodeling in three dimensions. The Journal of biological chemistry, 286 (42) , 36469-77More Information

Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I  (2011). Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility. Journal of virology, 85 (20) , 10487-98More Information

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun  (2019). Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49 (1) , 92-107More Information

Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi  (2011). R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of biological chemistry, 286 (27) , 24068-78More Information

Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina  (2018). LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome biology, 19 (1) , 189More Information

Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut  (2010). Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature medicine, 16 (10) , 1141-6More Information

Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang  (2018). Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer discovery, 8 (11) , 1438-1457More Information

Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A  (2018). Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current opinion in hematology, 25 (6) , 500-508More Information

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi  (2010). Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica, 95 (1) , 27-35More Information

Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi  (2018). Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. LeukemiaMore Information

Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A  (2009). Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica, 94 (7) , 1011-5More Information

Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut  (2018). Aging alters the epigenetic asymmetry of HSC division. PLoS biology, 16 (9) , e2003389More Information

Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping  (2008). Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling. Cell cycle (Georgetown, Tex.), 7 (21) , 3314-9More Information

Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi  (2018). A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia, 32 (9) , 2041-2046More Information

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C  (2008). Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer cell, 13 (6) , 483-95More Information

Cai, Xiongwei; Zheng, Yi; Speck, Nancy A  (2018). A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of visualized experiments : JoVE (138) More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun  (2018). Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 9 (1) , 670More Information

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T  (2018). TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 (5) , 1250-1262More Information

Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi  (2007). Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proceedings of the National Academy of Sciences of the United States of America, 104 (12) , 5091-6More Information

Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi  (2018). Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in molecular biology (Clifton, N.J.), 1821, 257-266More Information

Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A  (2006). Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood, 108 (6) , 2087-94More Information

Cai, Xiongwei; Zhou, Xuan; Zheng, Yi  (2018). In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. Methods in molecular biology (Clifton, N.J.), 1821, 247-256More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun  (2017). Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 8 (1) , 2099More Information

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut  (2017). Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 (11) , 2608-2621More Information

Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A  (2005). Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nature medicine, 11 (8) , 886-91More Information

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T  (2017). Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature immunology, 18 (2) , 236-245More Information

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying  (2005). MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 (1) , 60-5More Information

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A  (2015). Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nature communications, 6, 5914More Information

Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun  (2018). Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of immunology (Baltimore, Md. : 1950), 200 (7) , 2313-2326More Information

Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy  (2013). Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61 (11) , 1906-21More Information

Yang, Yingying; Dong, Panpan; Zhao, Jing; Zhou, Wei; Zhou, Yonghua; Xu, Yongliang; Mei, Congjin; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi  (2018). PKC?/? regulates Th17 differentiation and house dust mite-induced allergic airway inflammation. Biochimica et biophysica acta, 1864 (3) , 934-941More Information

Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong  (2018). Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory research, 19 (1) , 27More Information

Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi  (2013). Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proceedings of the National Academy of Sciences of the United States of America, 110 (8) , 3155-60More Information

Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi  (2017). RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem cell reports, 9 (6) , 1961-1975More Information

Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A  (2012). Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood, 120 (4) , 800-11More Information

Guo, Fukun; Zheng, Yi  (2017). Vav1: Friend and Foe of Cancer. Trends in cell biology, 27 (12) , 879-880More Information

Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei  (2017). YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of the United States of America, 114 (41) , 10918-10923More Information

Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C; Wunderlich, Mark; Hochstetler, Cindy L; Duan, Xin; Liu, Wei; Orr, Emily; Grimes, H Leighton; Mulloy, James C; Zheng, Yi  (2017). The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood, 130 (11) , 1336-1346More Information

Williams, David A; Zheng, Yi; Cancelas, Jose A  (2008). Rho GTPases and regulation of hematopoietic stem cell localization. Methods in enzymology, 439, 365-93More Information

Kalim, Khalid W; Zhang, Shuangmin; Chen, Xiaoyi; Li, Yuan; Yang, Jun-Qi; Zheng, Yi; Guo, Fukun  (2017). mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity. PloS one, 12 (8) , e0183266More Information

Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi  (2007). Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood, 110 (12) , 3853-61More Information

Hato, Takashi; Winfree, Seth; Day, Richard; Sandoval, Ruben M; Molitoris, Bruce A; Yoder, Mervin C; Wiggins, Roger C; Zheng, Yi; Dunn, Kenneth W; Dagher, Pierre C  (2017). Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures. Journal of the American Society of Nephrology : JASN, 28 (8) , 2420-2430More Information

Sinagoga, Katie L; Stone, William J; Schiesser, Jacqueline V; Schweitzer, Jamie I; Sampson, Leesa; Zheng, Yi; Wells, James M  (2017). Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (Cambridge, England), 144 (13) , 2402-2414More Information

Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M  (2019). Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific reports, 9 (1) , 11666More Information

El Zowalaty, Ahmed E; Li, Rong; Zheng, Yi; Lydon, John P; DeMayo, Francesco J; Ye, Xiaoqin  (2017). Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology, 158 (7) , 2168-2178More Information

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi  (2010). Rho GTPases in hematopoiesis and hemopathies. Blood, 115 (5) , 936-47More Information

Qiu, Sugan; Fan, Xiaolin; Yang, Yingying; Dong, Panpan; Zhou, Wei; Xu, Yongliang; Zhou, Yonghua; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi  (2017). Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. PloS one, 12 (6) , e0179565More Information

Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying  (2019). Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. HaematologicaMore Information

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun  (2019). Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of leukocyte biologyMore Information

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A  (2007). Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell, 12 (5) , 467-78More Information

Li, Jingjing; Miao, Lianjie; Zhao, Chen; Shaikh Qureshi, Wasay Mohiuddin; Shieh, David; Guo, Hua; Lu, Yangyang; Hu, Saiyang; Huang, Alice; Zhang, Lu; Cai, Chen-Leng; Wan, Leo Q; Xin, Hongbo; Vincent, Peter; Singer, Harold A; Zheng, Yi; Cleaver, Ondine; Fan, Zhen-Chuan; Wu, Mingfu  (2017). CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development (Cambridge, England), 144 (9) , 1635-1647More Information

Filippi, Marie-Dominique; Harris, Chad E; Meller, Jarek; Gu, Yi; Zheng, Yi; Williams, David A  (2004). Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nature immunology, 5 (7) , 744-51More Information

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A  (2019). The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications, 10 (1) , 46More Information

Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy  (2006). Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 (13) , 3390-5More Information

Akbar, Huzoor; Duan, Xin; Saleem, Saima; Davis, Ashley K; Zheng, YiRhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets. PloS one, 11 (9) , e0163227More Information

Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong  (2019). ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. HaematologicaMore Information

Barry, David M; Koo, Yeon; Norden, Pieter R; Wylie, Lyndsay A; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D Berfin; Zheng, Yi; Cobb, Melanie H; Davis, George E; Cleaver, Ondine  (2016). Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II. Circulation research, 119 (7) , 810-26More Information

Zandvakili, I; Lin, Y; Morris, J C; Zheng, Y  (2017). Rho GTPases: Anti- or pro-neoplastic targets?. Oncogene, 36 (23) , 3213-3222More Information

Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi  (2019). KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental hematologyMore Information

Imai, Fumiyasu; Ladle, David R; Leslie, Jennifer R; Duan, Xin; Rizvi, Tilat A; Ciraolo, Georgianne M; Zheng, Yi; Yoshida, Yutaka  (2016). Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 (21) , 5724-35More Information

Palazzo, A; Bluteau, O; Messaoudi, K; Marangoni, F; Chang, Y; Souquere, S; Pierron, G; Lapierre, V; Zheng, Y; Vainchenker, W; Raslova, H; Debili, N  (2016). The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation. Journal of thrombosis and haemostasis : JTH, 14 (12) , 2524-2535More Information

Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi  (2019). Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells, 8 (10) More Information

Nohata, Nijiro; Uchida, Yutaka; Stratman, Amber N; Adams, Ralf H; Zheng, Yi; Weinstein, Brant M; Mukouyama, Yoh-Suke; Gutkind, J Silvio  (2016). Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Developmental biology, 411 (2) , 183-194More Information

O'Hayre, M; Inoue, A; Kufareva, I; Wang, Z; Mikelis, C M; Drummond, R A; Avino, S; Finkel, K; Kalim, K W; DiPasquale, G; Guo, F; Aoki, J; Zheng, Y; Lionakis, M S; Molinolo, A A; Gutkind, J S  (2016). Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G?13/RhoA axis in B cells. Oncogene, 35 (29) , 3771-80More Information

Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun  (2019). Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in oncology, 9, 958More Information

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T  (2020). Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 (5) , 535-545More Information

Sampson, Leesa L; Davis, Ashley K; Grogg, Matthew W; Zheng, Yi  (2016). mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 (3) , 1263-75More Information

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Katayama, Kei-ichi; Melendez, Jaime; Baumann, Jessica M; Leslie, Jennifer R; Chauhan, Bharesh K; Nemkul, Niza; Lang, Richard A; Kuan, Chia-Yi; Zheng, Yi; Yoshida, Yutaka  (2011). Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proceedings of the National Academy of Sciences of the United States of America, 108 (18) , 7607-12More Information

Kalim, Khalid W; Yang, Jun-Qi; Modur, Vishnu; Nguyen, Phuong; Li, Yuan; Zheng, Yi; Guo, Fukun  (2021). Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in immunology, 12, 726393More Information

Melendez, Jaime; Stengel, Kristy; Zhou, Xuan; Chauhan, Bharesh K; Debidda, Marcella; Andreassen, Paul; Lang, Richard A; Zheng, Yi  (2011). RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. The Journal of biological chemistry, 286 (17) , 15132-7More Information

Zhang, Bin; Nguyen, Le Xuan Truong; Zhao, Dandan; Frankhouser, David E; Wang, Huafeng; Hoang, Dinh Hoa; Qiao, Junjing; Abundis, Christina; Brehove, Matthew; Su, Yu-Lin; Feng, Yuxin; Stein, Anthony; Ghoda, Lucy; Dorrance, Adrianne; Perrotti, Danilo; Chen, Zhen; Han, Anjia; Pichiorri, Flavia; Jin, Jie; Jovanovic-Talisman, Tijana; Caligiuri, Michael A; Kuo, Calvin J; Yoshimura, Akihiko; Li, Ling; Rockne, Russell C; Kortylewski, Marcin; Zheng, Yi; Carlesso, Nadia; Kuo, Ya-Huei; Marcucci, Guido  (2021). Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of hematology & oncology, 14 (1) , 122More Information

Guo, Fukun; Zhang, Shuangmin; Tripathi, Pulak; Mattner, Jochen; Phelan, James; Sproles, Alyssa; Mo, Jun; Wills-Karp, Marsha; Grimes, H Leighton; Hildeman, David; Zheng, Yi  (2011). Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PloS one, 6 (3) , e18002More Information

Guidi, Novella; Marka, Gina; Sakk, Vadim; Zheng, Yi; Florian, Maria Carolina; Geiger, Hartmut  (2021). An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem cells (Dayton, Ohio), 39 (8) , 1101-1106More Information

Akunuru, Shailaja; Palumbo, Joseph; Zhai, Qihui James; Zheng, Yi  (2011). Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PloS one, 6 (2) , e16951More Information

Fan, Yuping; Teng, Yan; Loison, Fabien; Pang, Aiming; Kasorn, Anongnard; Shao, Xinqi; Zhang, Cunling; Ren, Qian; Yu, Hongbo; Zheng, Yi; Cancelas, Jose A; Manis, John; Chai, Li; Park, Shin-Young; Zhao, Li; Xu, Yuanfu; Feng, Sizhou; Silberstein, Leslie E; Ma, Fengxia; Luo, Hongbo R  (2021). Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science translational medicine, 13 (604) More Information

Melendez, Jaime; Grogg, Matthew; Zheng, Yi  (2011). Signaling role of Cdc42 in regulating mammalian physiology. The Journal of biological chemistry, 286 (4) , 2375-81More Information

Tu, Zhaowei; Wang, Chen; Davis, Ashley K; Hu, Mengwen; Zhao, Chuntao; Xin, Mei; Lu, Q Richard; Zheng, Yi  (2021). The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138 (3) , 221-233More Information

Liu, Wei; Feng, Yuxin; Shang, Xun; Zheng, Yi  (2011). Rho GTPases in hematopoietic stem/progenitor cell migration. Methods in molecular biology (Clifton, N.J.), 750, 307-19More Information

Duan, Xin; Perveen, Rehana; Dandamudi, Akhila; Adili, Reheman; Johnson, James; Funk, Kevin; Berryman, Mark; Davis, Ashley Kuenzi; Holinstat, Michael; Zheng, Yi; Akbar, Huzoor  (2021). Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific reports, 11 (1) , 13170More Information

Guo, Fukun; Hildeman, David; Tripathi, Pulak; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi  (2010). Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 107 (43) , 18505-10More Information

Lin, Yuan; Watanabe-Chailland, Miki; Zheng, Yi  (2021). Protocol for structural and biochemical analyses of RhoA GTPase. STAR protocols, 2 (2) , 100541More Information

George, Alex; Pushkaran, Suvarnamala; Li, Lina; An, Xiuli; Zheng, Yi; Mohandas, Narla; Joiner, Clinton H; Kalfa, Theodosia A  (2010). Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood cells, molecules & diseases, 45 (1) , 41-5More Information

Lin, Yuan; Lu, Shaoyong; Zhang, Jian; Zheng, Yi  (2021). Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure (London, England : 1993), 29 (6) , 553-563.e5More Information

Bosco, Emily E; Ni, Wenjun; Wang, Lei; Guo, Fukun; Johnson, James F; Zheng, Yi  (2010). Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. Blood, 115 (16) , 3320-8More Information

Nalapareddy, Kodandaramireddy; Hassan, Aishlin; Sampson, Leesa L; Zheng, Yi; Geiger, Hartmut  (2021). Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience, 24 (4) , 102362More Information

Szczur, Kathleen; Zheng, Yi; Filippi, Marie-Dominique  (2009). The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood, 114 (20) , 4527-37More Information

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian  (2021). Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Blood, 137 (5) , 610-623More Information

Chauhan, Bharesh K; Disanza, Andrea; Choi, Sue-Yeon; Faber, Sonya C; Lou, Ming; Beggs, Hilary E; Scita, Giorgio; Zheng, Yi; Lang, Richard A  (2009). Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (Cambridge, England), 136 (21) , 3657-67More Information

Hegde, Shailaja; Wellendorf, Ashley M; Zheng, Yi; Cancelas, Jose A  (2021). Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion, 61 (2) , 557-567More Information

Xu, Haiming; Eleswarapu, Satyam; Geiger, Hartmut; Szczur, Kathleen; Daria, Deidre; Zheng, Yi; Settleman, Jeffrey; Srour, Edward F; Williams, David A; Filippi, Marie-Dominique  (2009). Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood, 114 (17) , 3557-66More Information

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; McCauley, Shelby; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I  (2021). Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 155, 293-303More Information

Guo, Fukun; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi  (2009). Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood, 114 (14) , 2909-16More Information

Fan, Cuiqing; Zhao, Chuntao; Zhang, Feng; Kesarwani, Meenu; Tu, Zhaowei; Cai, Xiongwei; Davis, Ashley Kuenzi; Xu, Lingli; Hochstetler, Cindy L; Chen, Xiaoyi; Guo, Fukun; Huang, Gang; Azam, Mohammad; Tian, Weidong; Lu, Q Richard; Zheng, Yi  (2021). Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America, 118 (1) More Information

Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D  (2009). Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of clinical investigation, 119 (10) , 3079-88More Information

Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro  (2020). Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 (1) , 204More Information

Marchioni, Filippo; Zheng, Yi  (2009). Targeting rho GTPases by peptidic structures. Current pharmaceutical design, 15 (21) , 2481-7

Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi  (2009). Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Developmental biology, 325 (1) , 162-70More Information

Zhang, Xiaoling; Shang, Xun; Guo, Fukun; Murphy, Kim; Kirby, Michelle; Kelly, Patrick; Reeves, Lilith; Smith, Franklin O; Williams, David A; Zheng, Yi; Pang, Qishen  (2008). Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood, 112 (5) , 1683-6More Information

Yang, Linda; Zheng, Yi  (2007). Cdc42: a signal coordinator in hematopoietic stem cell maintenance. Cell cycle (Georgetown, Tex.), 6 (12) , 1445-50

Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi  (2007). Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 (14) , 3884-93More Information

Shang, Xun; Moon, Sun Young; Zheng, Yi  (2007). p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways. The Journal of biological chemistry, 282 (12) , 8801-11More Information

Wang, Lei; Zheng, Yi  (2007). Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. Trends in cell biology, 17 (2) , 58-64More Information

Guo, Dagang; Tan, Ying-cai; Wang, Dawei; Madhusoodanan, K S; Zheng, Yi; Maack, Thomas; Zhang, J Jillian; Huang, Xin-Yun  (2007). A Rac-cGMP signaling pathway. Cell, 128 (2) , 341-55More Information

Wang, Lei; Yang, Linda; Debidda, Marcella; Witte, David; Zheng, Yi  (2007). Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 104 (4) , 1248-53More Information

Szczur, Kathleen; Xu, Haiming; Atkinson, Simon; Zheng, Yi; Filippi, Marie-Dominique  (2006). Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood, 108 (13) , 4205-13More Information

Debidda, Marcella; Williams, David A; Zheng, Yi  (2006). Rac1 GTPase regulates cell genomic stability and senescence. The Journal of biological chemistry, 281 (50) , 38519-28More Information

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Mohandas, Narla; Hartwig, John H; Fowler, Velia M; Johnson, James F; Joiner, Clinton H; Williams, David A; Zheng, Yi  (2006). Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood, 108 (12) , 3637-45More Information

Yang, Linda; Wang, Lei; Zheng, Yi  (2006). Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Molecular biology of the cell, 17 (11) , 4675-85More Information

Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi  (2006). Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proceedings of the National Academy of Sciences of the United States of America, 103 (44) , 16520-5More Information

Xing, Zhenlan; Ryan, Marnie A; Daria, Deidre; Nattamai, Kalpana J; Van Zant, Gary; Wang, Lei; Zheng, Yi; Geiger, Hartmut  (2006). Increased hematopoietic stem cell mobilization in aged mice. Blood, 108 (7) , 2190-7More Information

Guo, Fukun; Debidda, Marcella; Yang, Linda; Williams, David A; Zheng, Yi  (2006). Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. The Journal of biological chemistry, 281 (27) , 18652-9More Information

Wang, Lei; Yang, Linda; Filippi, Marie-Dominique; Williams, David A; Zheng, Yi  (2006). Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood, 107 (1) , 98-105More Information

Wang, Lei; Yang, Linda; Burns, Kevin; Kuan, Chia-Yi; Zheng, Yi  (2005). Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. Proceedings of the National Academy of Sciences of the United States of America, 102 (38) , 13484-9More Information

Debidda, Marcella; Wang, Lei; Zang, Heesuk; Poli, Valeria; Zheng, Yi  (2005). A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. The Journal of biological chemistry, 280 (17) , 17275-85More Information

Carstanjen, Dirk; Yamauchi, Akira; Koornneef, Annemart; Zang, Heesuk; Filippi, Marie-Dominique; Harris, Chad; Towe, Jason; Atkinson, Simon; Zheng, Yi; Dinauer, Mary C; Williams, David A  (2005). Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of immunology (Baltimore, Md. : 1950), 174 (8) , 4613-20

Gu, Yi; Zheng, Yi; Williams, David A  (2005). RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis?. Cell cycle (Georgetown, Tex.), 4 (2) , 201-2More Information

Wang, Lei; Zhu, Kejin; Zheng, Yi  (2004). Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains. Biochemistry, 43 (46) , 14584-93More Information

Guo, Fukun; Zheng, Yi  (2004). Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion. Oncogene, 23 (33) , 5577-85More Information

Gao, Yuan; Dickerson, J Bradley; Guo, Fukun; Zheng, Jie; Zheng, Yi  (2004). Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 101 (20) , 7618-23More Information

Cook-Mills, Joan M; Johnson, Jacob D; Deem, Tracy L; Ochi, Atsuo; Wang, Lei; Zheng, Yi  (2004). Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity. The Biochemical journal, 378 (Pt 2) , 539-47More Information

Guo, Fukun; Zheng, Yi  (2004). Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts. Molecular and cellular biology, 24 (3) , 1426-38

Debreceni, Balazs; Gao, Yuan; Guo, Fukun; Zhu, Kejin; Jia, Baoqing; Zheng, Yi  (2004). Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. The Journal of biological chemistry, 279 (5) , 3777-86More Information

Wang, Lei; Yang, Linda; Luo, Yongneng; Zheng, Yi  (2003). A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells. The Journal of biological chemistry, 278 (45) , 44617-25More Information

Zheng, Yi; Quilliam, Lawrence A  (2003). Activation of the Ras superfamily of small GTPases. Workshop on exchange factors. EMBO reports, 4 (5) , 463-8More Information

Guo, Fukun; Gao, Yuan; Wang, Lei; Zheng, Yi  (2003). p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities. The Journal of biological chemistry, 278 (16) , 14414-9More Information

Moon, Sun Young; Zang, Heesuk; Zheng, Yi  (2003). Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. The Journal of biological chemistry, 278 (6) , 4151-9More Information

Moon, Sun Young; Zheng, Yi  (2003). Rho GTPase-activating proteins in cell regulation. Trends in cell biology, 13 (1) , 13-22

Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L  (2018). Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget, 9 (37) , 24750-24765More Information

Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D  (2018). Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. CirculationMore Information

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