Nives Zimmermann

Nives Gorman Zimmermann

Associate Professor of Clinical Geo

Cardiovascular Rsrch Cntr

1925

COM Pathology Clinical - 0529

Cardiovascular Research Center
231 Albert Sabin Way
Cincinnati, Ohio 45267-0529

Education

Medical Degree, University of Zagreb Croatia, 1995

Residency, University of Cincinnati College of Medicine Cincinnati, Ohio, 2017 (Anatomic and Clinical Pathology)

Fellowship, Indiana University Indianapolis, IN, 2019 (Hematopathology)

Fellowship, Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, 2020 (Pediatric Pathology)

Research and Practice Interests

Hematopathology

Clinical Focus

Pathology

Specialities

Hematopathology

Pathology-Anatomic and Clinical

Certifications

American Board of Pathology (Anatomic and Clinical Pathology)

06/21/2018

American Board of Pathology (Hematology)

09/20/2019

Publications

Peer Reviewed Publications

Zhu, Xiang; Hogan, Simon Patrick; Molkentin, Jeffery D; Zimmermann, Nives (2016. ) Cyclophilin D Regulates Necrosis But Not Apoptosis of Murine Eosinophils.American journal of physiology. Gastrointestinal and liver physiology, , ajpgi.00389.2015

Zimmermann, Nives; Hagen, Matthew C; Schrager, Jason J; Hebbeler-Clark, Renee S; Masineni, Sreeharsha (2015. ) Utility of frozen section analysis for fungal organisms in soft tissue wound debridement margin determination.Diagnostic pathology, , 10 ,188

Zimmermann, Nives; Rothenberg, Marc E (2015. ) Mechanism of enhanced eosinophil survival in inflammation.Blood, , 125 (25 ) ,3831-2

Bochner, Bruce S; Zimmermann, Nives (2015. ) Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation.The Journal of allergy and clinical immunology, , 135 (3 ) ,598-608

Wen, Ting; Mingler, Melissa K; Wahl, Benjamin; Khorki, M Eyad; Pabst, Oliver; Zimmermann, Nives; Rothenberg, Marc E (2014. ) Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils.Journal of immunology (Baltimore, Md. : 1950), , 192 (12 ) ,5481-9

Zhu, Xiang; Mose, Eucabeth; Hogan, Simon P; Zimmermann, Nives (2014. ) Differential eosinophil and mast cell regulation: mast cell viability and accumulation in inflammatory tissue are independent of proton-sensing receptor GPR65.American journal of physiology. Gastrointestinal and liver physiology, , 306 (11 ) ,G974-82

Epstein, Tolly G; Kesavalu, Banurekha; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Zimmermann, Nives; Lummus, Zana; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Bernstein, David I (2013. ) Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics.The Journal of asthma : official journal of the Association for the Care of Asthma, , 50 (9 ) ,983-9

Kano, Gen; Almanan, Maha; Bochner, Bruce S; Zimmermann, Nives (2013. ) Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation.The Journal of allergy and clinical immunology, , 132 (2 ) ,437-45

Mao, Hui; Kano, Gen; Hudson, Sherry A; Brummet, Mary; Zimmermann, Nives; Zhu, Zhou; Bochner, Bruce S (2013. ) Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.PloS one, , 8 (6 ) ,e68143

Zhu, Xiang; Mose, Eucabeth; Zimmermann, Nives (2013. ) Proton channel HVCN1 is required for effector functions of mouse eosinophils.BMC immunology, , 14 ,24

Collison, Adam; Hatchwell, Luke; Verrills, Nicole; Wark, Peter A B; de Siqueira, Ana Pereira; Tooze, Melinda; Carpenter, Helen; Don, Anthony S; Morris, Jonathan C; Zimmermann, Nives; Bartlett, Nathan W; Rothenberg, Marc E; Johnston, Sebastian L; Foster, Paul S; Mattes, Joerg (2013. ) The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.Nature medicine, , 19 (2 ) ,232-7

Arumugam, Muthuvel; Ahrens, Richard; Osterfeld, Heather; Kottyan, Leah C; Shang, Xun; Maclennan, John A; Zimmermann, Nives; Zheng, Yi; Finkelman, Fred D; Hogan, Simon P (2011. ) Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.BMC immunology, , 12 ,14

Lacy, Paige; Willetts, Lian; Kim, John D; Lo, Andrea N; Lam, Bon; Maclean, Emily I; Moqbel, Redwan; Rothenberg, Marc E; Zimmermann, Nives (2011. ) Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2.International archives of allergy and immunology, , 156 (2 ) ,137-47

Niese, Kathryn A; Chiaramonte, Monica G; Ellies, Lesley G; Rothenberg, Marc E; Zimmermann, Nives (2010. ) The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis.Respiratory research, , 11 ,87

Gao, Pei-Song; Shimizu, Kenichi; Grant, Audrey V; Rafaels, Nicholas; Zhou, Lin-Fu; Hudson, Sherry A; Konno, Satoshi; Zimmermann, Nives; Araujo, Maria I; Ponte, Eduardo V; Cruz, Alvaro A; Nishimura, Masaharu; Su, Song-Nan; Hizawa, Nobuyuki; Beaty, Terry H; Mathias, Rasika A; Rothenberg, Marc E; Barnes, Kathleen C; Bochner, Bruce S (2010. ) Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.European journal of human genetics : EJHG, , 18 (6 ) ,713-9

Herbert, De'Broski R; Orekov, Tatyana; Roloson, Amanda; Ilies, Monica; Perkins, Charles; O'Brien, William; Cederbaum, Stephen; Christianson, David W; Zimmermann, Nives; Rothenberg, Marc E; Finkelman, Fred D (2010. ) Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.Journal of immunology (Baltimore, Md. : 1950), , 184 (11 ) ,6438-46

Kottyan, Leah C; Collier, Ann R; Cao, Khanh H; Niese, Kathryn A; Hedgebeth, Megan; Radu, Caius G; Witte, Owen N; Khurana Hershey, Gurjit K; Rothenberg, Marc E; Zimmermann, Nives (2009. ) Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.Blood, , 114 (13 ) ,2774-82

Niese, Kathryn A; Collier, Ann R; Hajek, Amanda R; Cederbaum, Stephen D; O'Brien, William E; Wills-Karp, Marsha; Rothenberg, Marc E; Zimmermann, Nives (2009. ) Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.BMC immunology, , 10 ,33

Bergeron, Céline; Boulet, Louis-Philippe; Page, Nathalie; Laviolette, Michel; Zimmermann, Nives; Rothenberg, Marc E; Hamid, Qutayba (2007. ) Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.The Journal of allergy and clinical immunology, , 119 (2 ) ,391-7

Rothenberg, Marc E; Doepker, Matthew P; Lewkowich, Ian P; Chiaramonte, Monica G; Stringer, Keith F; Finkelman, Fred D; MacLeod, Carol L; Ellies, Lesley G; Zimmermann, Nives (2006. ) Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.Proceedings of the National Academy of Sciences of the United States of America, , 103 (40 ) ,14895-900

Zimmermann, Nives; Rothenberg, Marc E (2006. ) The arginine-arginase balance in asthma and lung inflammation.European journal of pharmacology, , 533 (1-3 ) ,253-62

Pope, Samuel M; Zimmermann, Nives; Stringer, Keith F; Karow, Margaret L; Rothenberg, Marc E (2005. ) The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. Journal of immunology (Baltimore, Md. : 1950), , 175 (8 ) ,5341-50

Fulkerson, Patricia C; Zhu, Hongyan; Williams, David A; Zimmermann, Nives; Rothenberg, Marc E (2005. ) CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.Blood, , 106 (2 ) ,436-43

Zimmermann, Nives; Doepker, Matthew P; Witte, David P; Stringer, Keith F; Fulkerson, Patricia C; Pope, Samuel M; Brandt, Eric B; Mishra, Anil; King, Nina E; Nikolaidis, Nikolaos M; Wills-Karp, Marsha; Finkelman, Fred D; Rothenberg, Marc E (2005. ) Expression and regulation of small proline-rich protein 2 in allergic inflammation.American journal of respiratory cell and molecular biology, , 32 (5 ) ,428-35

Pope, Samuel M; Fulkerson, Patricia C; Blanchard, Carine; Akei, Hiroko Saito; Nikolaidis, Nikolaos M; Zimmermann, Nives; Molkentin, Jeffery D; Rothenberg, Marc E (2005. ) Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation.The Journal of biological chemistry, , 280 (14 ) ,13952-61

Zimmermann, Nives; Colyer, Jessica L; Koch, Laura E; Rothenberg, Marc E (2005. ) Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1.BMC immunology, , 6 ,7

Fulkerson, Patricia C; Zimmermann, Nives; Hassman, Lynn M; Finkelman, Fred D; Rothenberg, Marc E (2004. ) Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. Journal of immunology (Baltimore, Md. : 1950), , 173 (12 ) ,7565-74

King, Nina E; Rothenberg, Marc E; Zimmermann, Nives (2004. ) Arginine in asthma and lung inflammation. The Journal of nutrition, , 134 (10 Suppl ) ,2830S-2836S; discuss

King, Nina E; Zimmermann, Nives; Pope, Samuel M; Fulkerson, Patricia C; Nikolaidis, Nikolaos M; Mishra, Anil; Witte, David P; Rothenberg, Marc E (2004. ) Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma.American journal of respiratory cell and molecular biology, , 31 (3 ) ,257-65

Fulkerson, Patricia C; Zimmermann, Nives; Brandt, Eric B; Muntel, Emily E; Doepker, Matthew P; Kavanaugh, Jessica L; Mishra, Anil; Witte, David P; Zhang, Hongwei; Farber, Joshua M; Yang, Ming; Foster, Paul S; Rothenberg, Marc E (2004. ) Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9).Proceedings of the National Academy of Sciences of the United States of America, , 101 (7 ) ,1987-92

Zimmermann, Nives; Mishra, Anil; King, Nina E; Fulkerson, Patricia C; Doepker, Matthew P; Nikolaidis, Nikolaos M; Kindinger, Laura E; Moulton, Elizabeth A; Aronow, Bruce J; Rothenberg, Marc E (2004. ) Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. Journal of immunology (Baltimore, Md. : 1950), , 172 (3 ) ,1815-24

Brandt, Eric B; Strait, Richard T; Hershko, Dan; Wang, Quan; Muntel, Emily E; Scribner, Troy A; Zimmermann, Nives; Finkelman, Fred D; Rothenberg, Marc E (2003. ) Mast cells are required for experimental oral allergen-induced diarrhea.The Journal of clinical investigation, , 112 (11 ) ,1666-77

Aizawa, Hideyuki; Zimmermann, Nives; Carrigan, Patricia E; Lee, James J; Rothenberg, Marc E; Bochner, Bruce S (2003. ) Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics, , 82 (5 ) ,521-30

Yang, Ming; Hogan, Simon P; Mahalingam, Surendran; Pope, Sam M; Zimmermann, Nives; Fulkerson, Patricia; Dent, Lindsay A; Young, Ian G; Matthaei, Klaus I; Rothenberg, Marc E; Foster, Paul S (2003. ) Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity.The Journal of allergy and clinical immunology, , 112 (5 ) ,935-43

Nikolaidis, Nikolaos M; Zimmermann, Nives; King, Nina E; Mishra, Anil; Pope, Samuel M; Finkelman, Fred D; Rothenberg, Marc E (2003. ) Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung.American journal of respiratory cell and molecular biology, , 29 (4 ) ,458-64

Zimmermann, Nives; King, Nina E; Laporte, Johanne; Yang, Ming; Mishra, Anil; Pope, Sam M; Muntel, Emily E; Witte, David P; Pegg, Anthony A; Foster, Paul S; Hamid, Qutayba; Rothenberg, Marc E (2003. ) Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.The Journal of clinical investigation, , 111 (12 ) ,1863-74

Zimmermann, Nives; Hershey, Gurjit Khurana; Foster, Paul S; Rothenberg, Marc E (2003. ) Chemokines in asthma: cooperative interaction between chemokines and IL-13. The Journal of allergy and clinical immunology, , 111 (2 ) ,227-42; quiz 243

Zimmermann, Nives; Rothenberg, Marc E (2003. ) Receptor internalization is required for eotaxin-induced responses in human eosinophils. The Journal of allergy and clinical immunology, , 111 (1 ) ,97-105

Zimmermann, Nives; Stanek, Jerzy (2017. ) Perinatal Case of Fatal Simpson-Golabi-Behmel Syndrome with Hyperplasia of Seminiferous Tubules. The American journal of case reports, , 18 ,649-655

Kano, Gen; Bochner, Bruce S; Zimmermann, Nives (2017. ) Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases.Immunobiology, , 222 (2 ) ,343-349

O'Shea, Kelly M; Rochman, Mark; Shoda, Tetsuo; Zimmermann, Nives; Caldwell, Julie; Rothenberg, Marc E (2020. ) Eosinophilic esophagitis with extremely high esophageal eosinophil counts.The Journal of allergy and clinical immunology, ,

Zimmermann, Nives; Nassiri, Mehdi; Zhou, Jiehao; Miller, Adam M; Zhang, Shanxiang (2020. ) Myeloid neoplasm with a novel cryptic PDGFRB rearrangement detected by next-generation sequencing.Cancer genetics, , 244 ,55-59

Zimmermann, Nives; Gibbons, William J; Homan, Shelli M; Prows, Daniel R (2019. ) Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci.BMC genomics, , 20 (1 ) ,727

Prows, Daniel R; Klingler, Andrea; Gibbons, William J; Homan, Shelli M; Zimmermann, Nives (2019. ) Characterization of a mouse model of hypereosinophilia-associated heart disease.American journal of physiology. Heart and circulatory physiology, , 317 (2 ) ,H405-H414

Legrand, Fanny; Cao, Yun; Wechsler, Joshua B; Zhu, Xiang; Zimmermann, Nives; Rampertaap, Shakuntala; Monsale, Joseph; Romito, Kimberly; Youngblood, Bradford A; Brock, Emily C; Makiya, Michelle A; Tomasevic, Nenad; Bebbington, Christopher; Maric, Irina; Metcalfe, Dean D; Bochner, Bruce S; Klion, Amy D (2019. ) Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.The Journal of allergy and clinical immunology, , 143 (6 ) ,2227-2237.e10

Criss, Benjamin E; Zimmermann, Nives; Butler, Randall T (2019. ) Previously Unreported Complication of Coronary Artery Bypass Grafting: Suture Rupture Resulting in Patient's Death.Journal of forensic sciences, , 64 (1 ) ,281-283

Zimmermann, Nives; Wikenheiser-Brokamp, Kathryn A (2018. ) Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 121 (2 ) ,179-185

Shoda, Tetsuo; Wen, Ting; Aceves, Seema S; Abonia, J Pablo; Atkins, Dan; Bonis, Peter A; Caldwell, Julie M; Capocelli, Kelley E; Carpenter, Christina L; Collins, Margaret H; Dellon, Evan S; Eby, Michael D; Gonsalves, Nirmala; Gupta, Sandeep K; Falk, Gary W; Hirano, Ikuo; Menard-Katcher, Paul; Kuhl, Jonathan T; Krischer, Jeffrey P; Leung, John; Mukkada, Vincent A; Spergel, Jonathan M; Trimarchi, Michael P; Yang, Guang-Yu; Zimmermann, Nives; Furuta, Glenn T; Rothenberg, Marc E (2018. ) Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study.The lancet. Gastroenterology & hepatology, , 3 (7 ) ,477-488

Contact Information

Academic - Cardiovascular Research Center
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0529
Phone: 5135580135
Fax: (513) 584-3892
nives.zimmermann@uc.edu