Bryan Mackenzie

Bryan Mackenzie , PhD

Professor

Academic Director, Special Masters Program in Physiology

Office 4257A Medical Sciences Building
Laboratory 4060 Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267-0576
Phone (513)558-3627
Fax (513)558-5738
Email bryan.mackenzie@uc.edu

Professional Summary

Research Profile

Iron metabolism is a topic of major public-health importance because of the prevalence of iron deficiency and of hereditary iron disorders. Our interest is in iron transporters—their molecular physiology, and their roles in iron homeostasis and iron disorders. Divalent metal-ion transporter-1 (DMT1) is indispensable for iron homeostasis. It is the front-line, primary route of iron uptake in the intestine. DMT1 is also responsible for mobilization of iron from the endosome to cytosol, a crucial step in the transferrin-associated uptake of iron in erythroid precursor cells. Export of iron from enterocytes and from macrophages (recycling iron from senescent red blood cells) is mediated by ferroportin (Fpn). Our research is focused on the molecular physiology of iron transporters DMT1 and Fpn, their structure–function and cellular roles. Work in the Mackenzie Lab utilizes transport assays in RNA-injected Xenopus oocytes expressing iron transporters, and examining iron transport and homeostasis in genetically modified mouse models.

Publications

Peer-reviewed publications at ORCID.org

Teaching and Training Programs


Courses Taught

Undergraduate Graduate Medical School
  • Medical School M1 Physician & Society Block—Biostatistics, Lecturer
  • Medical School M2 Cardiovascular & Hematology Block—Iron metabolism and its disorders, Lecturer
 
 

Contact Information

Academic - Office 4257A Medical Sciences Building
Laboratory 4060 Medical Sciences Building
Cincinnati  Ohio, 45267-0576
Phone: (513)558-3627
Fax: (513)558-5738
bryan.mackenzie@uc.edu