Bryan Mackenzie , PhD

Research Profile

Iron metabolism is a topic of major public-health importance because of the prevalence of iron deficiency and of hereditary iron disorders. Our interest is in iron transporters—their molecular physiology, and their roles in iron homeostasis and iron disorders. Divalent metal-ion transporter-1 (DMT1) is indispensable for iron homeostasis. It is the front-line, primary route of iron uptake in the intestine. DMT1 is also responsible for mobilization of iron from the endosome to cytosol, a crucial step in the transferrin-associated uptake of iron in erythroid precursor cells. Export of iron from enterocytes and from macrophages (recycling iron from senescent red blood cells) is mediated by ferroportin (Fpn). Our research is focused on the molecular physiology of iron transporters DMT1 and Fpn, their structure–function and cellular roles. Work in the Mackenzie Lab utilizes transport assays in RNA-injected Xenopus oocytes expressing iron transporters, and examining iron transport and homeostasis in genetically modified mouse models.

Publications

Peer-reviewed publications at ORCID.org

Teaching and Training Programs

• Medical Sciences Baccalaureate Program
• Special Master’s Program in Physiology
• PhD Program in Systems Biology & Physiology
• Medical Scientist Training Program (MD, PhD)

• Biomedical Research Rotation MED3030, Course Director
• Statistics and Experimental Design for the Biomedical Sciences MEDS3023C, Course Director
• Interprofessional Education for Health Sciences and Medicine MEDS3060, Course Director

• Statistics and Experimental Design for the Biomedical Sciences MCP8050C, Course Director
• Molecular & Cellular Biology (GNTD7001) —Channels, pumps and transporters, Lecturer
• Graduate Medical Physiology 2 (MCP8042)—Blood: Hematopoiesis, iron metabolism, and hemostasis, Section Director
• Interprofessional Education for Health Sciences and Medicine MCP8060, Course Director

• Medical School M1 Physician & Society Block—Biostatistics, Lecturer
• Medical School M2 Cardiovascular & Hematology Block—Iron metabolism and its disorders, Lecturer

Membrane transport  |  Iron metabolism and its disorders  |  Iron absorption  |  Structure–function of membrane-transport proteins
Publications and Citations at Google Scholar

Peer Reviewed Publications

View peer-reviewed publications at ORCID.org

Academic - Office 4257A Medical Sciences Building
Laboratory 4060 Medical Sciences Building
Cincinnati  Ohio, 45267-0576
Phone: (513)558-3627
Fax: (513)558-5738
bryan.mackenzie@uc.edu