Bryan Mackenzie , PHD

Research Profile
Iron metabolism is a topic of major public-health importance because of the prevalence of iron deficiency and of hereditary iron disorders. Our interest is in iron transporters—their molecular physiology and structure–function, and their roles in iron homeostasis and iron disorders. Divalent metal-ion transporter-1 (DMT1) is indispensable for iron homeostasis. It is the front-line, primary route of iron uptake in the intestine. DMT1 is also responsible for mobilization of iron from the endosome to cytosol, a crucial step in the transferrin-associated uptake of iron in erythroid precursor cells. Export of iron from enterocytes and from macrophages (recycling iron from senescent red blood cells) is mediated by ferroportin (Fpn). Work in the Mackenzie Lab utilizes transport assays in RNA-injected Xenopus oocytes expressing iron transporters, and examining iron transport and homeostasis in genetically modified mouse models.

Teaching and Training Programs

• Medical Sciences Baccalaureate Program | Director of Research Experiences
• Special Master’s Program in Physiology | Academic Director
• PhD Program in Pharmacology & Physiology
• Medical Scientist Training Program 

• First Experience in Biomedical Research MEDS2130 | Course Director
• Biomedical Research Rotation MEDS3030 | Course Director
• Interprofessional Education for Health Sciences and Medicine MEDS3060 | Course Director
• Biomedical Research Capstone 1 and 2 MEDS5030–MEDS5031 | Course Director

• Graduate Medical Physiology 1 MCP8047 | Lecturer (Membrane transport; Hemophysiology)
• Statistics and Experimental Design for the Biomedical Sciences MCP8050C | Course Director
• Molecular & Cellular Biology GNTD7001 | Lecturer (Channels, pumps and transporters)
• Interprofessional Education for Health Sciences and Medicine MCP8060 | Course Director

• Physician and Society 101 | Lecturer (Biostatistics)

Our research program is focused on the molecular physiology of iron transporters and their roles in iron homeostasis and iron disorders. View More

Membrane transport | Transporter structure–function | Iron homeostasis and iron disorders | Iron absorption

Peer Reviewed Publications

View Bryan Mackenzie's Publications at ORCID.org

View Bryan Mackenzie's Publications and Citations at Google Scholar

Advances in Physiology Education Associate Editor Type:Editorial Service 2016 -2019

Advances in Physiology Education (Deputy Editor-in-Chief ) Type:Editorial Service 2020 -To Present

Academic - Office 4257A Medical Sciences Building
Laboratory 4060 Medical Sciences Building
Cincinnati  Ohio, 45267-0576
Phone: 5135583627
bryan.mackenzie@uc.edu